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Conserved domains on  [gi|16129459|ref|NP_416017|]
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two-component system connector SafA [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

two-component system connector SafA( domain architecture ID 12181547)

two-component system connector SafA connects the signal transduction between the two-component systems EvgS/EvgA and PhoQ/PhoP, by directly interacting with PhoQ and thus activating the PhoQ/PhoP system, in response to acid stress conditions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SafA pfam17073
Two-component-system connector protein; SafA is a bacterial transmembrane protein family that ...
 1-64 9.89e-26

Two-component-system connector protein; SafA is a bacterial transmembrane protein family that connects the signal transduction between the two component systems EvgS/EvgA and PhoQ/Phop. SafA interacts with PhoQ, leading to the PhoQ/PhoP system activation in response to acid stress conditions.


:

Pssm-ID: 319116  Cd Length: 64  Bit Score: 89.31  E-value: 9.89e-26
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16129459    1 MHATTVKNKITQRDNYKEIMSAIVVVLLLTLTLIAIFSAIDQLSISEMGRIARDLTHFIINSLQ 64
Cdd:pfam17073  1 MHATTVKNKITQRDNYKEIMSAIVVVLLLTLTLIAIFSAIDQLGISEMGRIARDLTHFIINSLQ 64
 
Name Accession Description Interval E-value
SafA pfam17073
Two-component-system connector protein; SafA is a bacterial transmembrane protein family that ...
 1-64 9.89e-26

Two-component-system connector protein; SafA is a bacterial transmembrane protein family that connects the signal transduction between the two component systems EvgS/EvgA and PhoQ/Phop. SafA interacts with PhoQ, leading to the PhoQ/PhoP system activation in response to acid stress conditions.


Pssm-ID: 319116  Cd Length: 64  Bit Score: 89.31  E-value: 9.89e-26
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16129459    1 MHATTVKNKITQRDNYKEIMSAIVVVLLLTLTLIAIFSAIDQLSISEMGRIARDLTHFIINSLQ 64
Cdd:pfam17073  1 MHATTVKNKITQRDNYKEIMSAIVVVLLLTLTLIAIFSAIDQLGISEMGRIARDLTHFIINSLQ 64
 
Name Accession Description Interval E-value
SafA pfam17073
Two-component-system connector protein; SafA is a bacterial transmembrane protein family that ...
 1-64 9.89e-26

Two-component-system connector protein; SafA is a bacterial transmembrane protein family that connects the signal transduction between the two component systems EvgS/EvgA and PhoQ/Phop. SafA interacts with PhoQ, leading to the PhoQ/PhoP system activation in response to acid stress conditions.


Pssm-ID: 319116  Cd Length: 64  Bit Score: 89.31  E-value: 9.89e-26
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16129459    1 MHATTVKNKITQRDNYKEIMSAIVVVLLLTLTLIAIFSAIDQLSISEMGRIARDLTHFIINSLQ 64
Cdd:pfam17073  1 MHATTVKNKITQRDNYKEIMSAIVVVLLLTLTLIAIFSAIDQLGISEMGRIARDLTHFIINSLQ 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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