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Conserved domains on  [gi|16129528|ref|NP_416087|]
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putative DNA-binding transcriptional regulator DicC [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

helix-turn-helix domain-containing protein; LacI family DNA-binding transcriptional regulator( domain architecture ID 10013332)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family; HTH domain binds DNA and may function as a transcriptional regulator| LacI family DNA-binding transcriptional regulator functions as an activator or repressor by binding a specific effector ligand that either decreases (induction) or increases DNA-binding affinity (co-repression)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK09744 PRK09744
DNA-binding transcriptional regulator DicC; Provisional
 1-76 4.33e-49

DNA-binding transcriptional regulator DicC; Provisional


:

Pssm-ID: 137503  Cd Length: 75  Bit Score: 148.96  E-value: 4.33e-49
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16129528   1 MLKTDALLYFGSKTKLAQAAGIRLASLYSWkGDLVPEGRAMRLQEASGGELQYDPKVYDEYRKTKRAGRLNNENHS 76
Cdd:PRK09744  1 MLKIDAIAFFGSKTKLANAAGVRLASVAAW-GELVPEGRAMRLQEASGGELQYDPKVYDEYRKAKRAGRLNNENHS 75
 
Name Accession Description Interval E-value
PRK09744 PRK09744
DNA-binding transcriptional regulator DicC; Provisional
 1-76 4.33e-49

DNA-binding transcriptional regulator DicC; Provisional


Pssm-ID: 137503  Cd Length: 75  Bit Score: 148.96  E-value: 4.33e-49
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16129528   1 MLKTDALLYFGSKTKLAQAAGIRLASLYSWkGDLVPEGRAMRLQEASGGELQYDPKVYDEYRKTKRAGRLNNENHS 76
Cdd:PRK09744  1 MLKIDAIAFFGSKTKLANAAGVRLASVAAW-GELVPEGRAMRLQEASGGELQYDPKVYDEYRKAKRAGRLNNENHS 75
P22_Cro pfam14549
DNA-binding transcriptional regulator Cro; Bacteriophage P22 Cro protein represses genes ...
 3-58 1.36e-10

DNA-binding transcriptional regulator Cro; Bacteriophage P22 Cro protein represses genes normally expressed in early phage development and is necessary for the late stage of lytic growth. It does this by binding to the OL and OR operator-regions normally used by the repressor protein for lysogenic maintenance.


Pssm-ID: 405268  Cd Length: 60  Bit Score: 51.22  E-value: 1.36e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 16129528    3 KTDALLYFGSKTKLAQAAGIRLASLYSWkGDLVPEGRAMRLQEASGGELQYDPKVY 58
Cdd:pfam14549  2 KKDVIAHFGGVSKVAKALGVTPGAVSQW-GEDVPELRAYQIERLTAGALKVQPRIV 56
YdaS COG4197
DNA-binding transcriptional regulator YdaS, prophage-encoded, Cro superfamily [Transcription];
5-50 2.77e-04

DNA-binding transcriptional regulator YdaS, prophage-encoded, Cro superfamily [Transcription];


Pssm-ID: 443351  Cd Length: 68  Bit Score: 35.27  E-value: 2.77e-04
                       10        20        30        40
               ....*....|....*....|....*....|....*....|....*...
gi 16129528  5 DALLYFGSKTKLAQAAGIRLASLYSWKGDL--VPEGRAMRLQEASGGE 50
Cdd:COG4197  3 KAIEALGSQSALARALGVSQQAVSQWLNGKrrVPAERCLAIERATGGA 50
 
Name Accession Description Interval E-value
PRK09744 PRK09744
DNA-binding transcriptional regulator DicC; Provisional
 1-76 4.33e-49

DNA-binding transcriptional regulator DicC; Provisional


Pssm-ID: 137503  Cd Length: 75  Bit Score: 148.96  E-value: 4.33e-49
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16129528   1 MLKTDALLYFGSKTKLAQAAGIRLASLYSWkGDLVPEGRAMRLQEASGGELQYDPKVYDEYRKTKRAGRLNNENHS 76
Cdd:PRK09744  1 MLKIDAIAFFGSKTKLANAAGVRLASVAAW-GELVPEGRAMRLQEASGGELQYDPKVYDEYRKAKRAGRLNNENHS 75
P22_Cro pfam14549
DNA-binding transcriptional regulator Cro; Bacteriophage P22 Cro protein represses genes ...
 3-58 1.36e-10

DNA-binding transcriptional regulator Cro; Bacteriophage P22 Cro protein represses genes normally expressed in early phage development and is necessary for the late stage of lytic growth. It does this by binding to the OL and OR operator-regions normally used by the repressor protein for lysogenic maintenance.


Pssm-ID: 405268  Cd Length: 60  Bit Score: 51.22  E-value: 1.36e-10
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 16129528    3 KTDALLYFGSKTKLAQAAGIRLASLYSWkGDLVPEGRAMRLQEASGGELQYDPKVY 58
Cdd:pfam14549  2 KKDVIAHFGGVSKVAKALGVTPGAVSQW-GEDVPELRAYQIERLTAGALKVQPRIV 56
YdaS COG4197
DNA-binding transcriptional regulator YdaS, prophage-encoded, Cro superfamily [Transcription];
5-50 2.77e-04

DNA-binding transcriptional regulator YdaS, prophage-encoded, Cro superfamily [Transcription];


Pssm-ID: 443351  Cd Length: 68  Bit Score: 35.27  E-value: 2.77e-04
                       10        20        30        40
               ....*....|....*....|....*....|....*....|....*...
gi 16129528  5 DALLYFGSKTKLAQAAGIRLASLYSWKGDL--VPEGRAMRLQEASGGE 50
Cdd:COG4197  3 KAIEALGSQSALARALGVSQQAVSQWLNGKrrVPAERCLAIERATGGA 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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