endonuclease III [Escherichia coli str. K-12 substr. MG1655]
endonuclease III( domain architecture ID 11484879)
endonuclease III is a DNA repair enzyme that has both DNA N-glycosylase and AP-lyase activities
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
PRK10702 | PRK10702 | endonuclease III; Provisional |
1-211 | 4.22e-165 | ||||
endonuclease III; Provisional : Pssm-ID: 182661 [Multi-domain] Cd Length: 211 Bit Score: 452.93 E-value: 4.22e-165
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Name | Accession | Description | Interval | E-value | ||||
PRK10702 | PRK10702 | endonuclease III; Provisional |
1-211 | 4.22e-165 | ||||
endonuclease III; Provisional Pssm-ID: 182661 [Multi-domain] Cd Length: 211 Bit Score: 452.93 E-value: 4.22e-165
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nth | TIGR01083 | endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily ... |
3-194 | 1.73e-123 | ||||
endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily (HhH-GPD: Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate). The major members of the superfamily are nth and mutY. [DNA metabolism, DNA replication, recombination, and repair] Pssm-ID: 273434 [Multi-domain] Cd Length: 192 Bit Score: 347.06 E-value: 1.73e-123
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Nth | COG0177 | Endonuclease III [Replication, recombination and repair]; |
10-207 | 5.55e-123 | ||||
Endonuclease III [Replication, recombination and repair]; Pssm-ID: 439947 [Multi-domain] Cd Length: 198 Bit Score: 345.93 E-value: 5.55e-123
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ENDO3c | cd00056 | endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ... |
30-183 | 3.91e-53 | ||||
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases Pssm-ID: 238013 [Multi-domain] Cd Length: 158 Bit Score: 167.80 E-value: 3.91e-53
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ENDO3c | smart00478 | endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ... |
38-185 | 7.93e-51 | ||||
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases Pssm-ID: 214684 [Multi-domain] Cd Length: 149 Bit Score: 161.28 E-value: 7.93e-51
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HhH-GPD | pfam00730 | HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of ... |
34-168 | 6.39e-42 | ||||
HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family. Pssm-ID: 425841 [Multi-domain] Cd Length: 141 Bit Score: 138.57 E-value: 6.39e-42
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Name | Accession | Description | Interval | E-value | ||||
PRK10702 | PRK10702 | endonuclease III; Provisional |
1-211 | 4.22e-165 | ||||
endonuclease III; Provisional Pssm-ID: 182661 [Multi-domain] Cd Length: 211 Bit Score: 452.93 E-value: 4.22e-165
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nth | TIGR01083 | endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily ... |
3-194 | 1.73e-123 | ||||
endonuclease III; This equivalog model identifes nth members of the pfam00730 superfamily (HhH-GPD: Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate). The major members of the superfamily are nth and mutY. [DNA metabolism, DNA replication, recombination, and repair] Pssm-ID: 273434 [Multi-domain] Cd Length: 192 Bit Score: 347.06 E-value: 1.73e-123
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Nth | COG0177 | Endonuclease III [Replication, recombination and repair]; |
10-207 | 5.55e-123 | ||||
Endonuclease III [Replication, recombination and repair]; Pssm-ID: 439947 [Multi-domain] Cd Length: 198 Bit Score: 345.93 E-value: 5.55e-123
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ENDO3c | cd00056 | endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ... |
30-183 | 3.91e-53 | ||||
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases Pssm-ID: 238013 [Multi-domain] Cd Length: 158 Bit Score: 167.80 E-value: 3.91e-53
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ENDO3c | smart00478 | endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), ... |
38-185 | 7.93e-51 | ||||
endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases Pssm-ID: 214684 [Multi-domain] Cd Length: 149 Bit Score: 161.28 E-value: 7.93e-51
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HhH-GPD | pfam00730 | HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of ... |
34-168 | 6.39e-42 | ||||
HhH-GPD superfamily base excision DNA repair protein; This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases. The methyl-CPG binding protein MBD4 also contains a related domain that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family. Pssm-ID: 425841 [Multi-domain] Cd Length: 141 Bit Score: 138.57 E-value: 6.39e-42
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HP0602 | COG2231 | 3-Methyladenine DNA glycosylase, HhH-GPD/Endo3 superfamily [Replication, recombination and ... |
28-205 | 2.86e-23 | ||||
3-Methyladenine DNA glycosylase, HhH-GPD/Endo3 superfamily [Replication, recombination and repair]; Pssm-ID: 441832 [Multi-domain] Cd Length: 220 Bit Score: 92.60 E-value: 2.86e-23
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MutY | COG1194 | Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and ... |
80-204 | 3.56e-15 | ||||
Adenine-specific DNA glycosylase, acts on AG and A-oxoG pairs [Replication, recombination and repair]; Pssm-ID: 440807 [Multi-domain] Cd Length: 350 Bit Score: 72.86 E-value: 3.56e-15
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PRK10880 | PRK10880 | adenine DNA glycosylase; |
80-203 | 5.12e-11 | ||||
adenine DNA glycosylase; Pssm-ID: 182805 [Multi-domain] Cd Length: 350 Bit Score: 60.88 E-value: 5.12e-11
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AlkA | COG0122 | 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and ... |
28-141 | 2.30e-10 | ||||
3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [Replication, recombination and repair]; Pssm-ID: 439892 [Multi-domain] Cd Length: 255 Bit Score: 58.36 E-value: 2.30e-10
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PRK13910 | PRK13910 | DNA glycosylase MutY; Provisional |
82-203 | 1.54e-08 | ||||
DNA glycosylase MutY; Provisional Pssm-ID: 172427 [Multi-domain] Cd Length: 289 Bit Score: 53.49 E-value: 1.54e-08
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HHH | pfam00633 | Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated ... |
100-126 | 2.51e-05 | ||||
Helix-hairpin-helix motif; The helix-hairpin-helix DNA-binding motif is found to be duplicated in the central domain of RuvA. The HhH domain of DisA, a bacterial checkpoint control protein, is a DNA-binding domain. Pssm-ID: 425789 [Multi-domain] Cd Length: 30 Bit Score: 40.09 E-value: 2.51e-05
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FES | smart00525 | iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); ... |
186-206 | 1.11e-04 | ||||
iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Pssm-ID: 197771 [Multi-domain] Cd Length: 21 Bit Score: 37.92 E-value: 1.11e-04
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ogg | TIGR00588 | 8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known ... |
29-147 | 2.20e-04 | ||||
8-oxoguanine DNA-glycosylase (ogg); All proteins in this family for which functions are known are 8-oxo-guanaine DNA glycosylases that function in base excision repair. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). This family is distantly realted to the Nth-MutY superfamily. [DNA metabolism, DNA replication, recombination, and repair] Pssm-ID: 211589 [Multi-domain] Cd Length: 310 Bit Score: 41.05 E-value: 2.20e-04
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EndIII_4Fe-2S | pfam10576 | Iron-sulfur binding domain of endonuclease III; Escherichia coli endonuclease III (EC 4.2.99. ... |
187-203 | 1.37e-03 | ||||
Iron-sulfur binding domain of endonuclease III; Escherichia coli endonuclease III (EC 4.2.99.18) is a DNA repair enzyme that acts both as a DNA N-glycosylase, removing oxidized pyrimidines from DNA, and as an apurinic/apyrimidinic (AP) endonuclease, introducing a single-strand nick at the site from which the damaged base was removed. Endonuclease III is an iron-sulfur protein that binds a single 4Fe-4S cluster. The 4Fe-4S cluster does not seem to be important for catalytic activity, but is probably involved in the proper positioning of the enzyme along the DNA strand. The 4Fe-4S cluster is bound by four cysteines which are all located in a 17 amino acid region at the C-terminal end of endonuclease III. A similar region is also present in the central section of mutY and in the C-terminus of ORF-10 and of the Micro-coccus UV endonuclease. Pssm-ID: 463153 [Multi-domain] Cd Length: 17 Bit Score: 35.05 E-value: 1.37e-03
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PRK13913 | PRK13913 | 3-methyladenine DNA glycosylase; Provisional |
76-143 | 5.37e-03 | ||||
3-methyladenine DNA glycosylase; Provisional Pssm-ID: 184390 Cd Length: 218 Bit Score: 36.75 E-value: 5.37e-03
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Blast search parameters | ||||
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