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Conserved domains on  [gi|16129592|ref|NP_416151|]
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dipeptide/tripeptide:H(+) symporter DtpA [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

MFS transporter( domain architecture ID 10013279)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
tppB PRK09584
dipeptide/tripeptide permease DtpA;
1-487 0e+00

dipeptide/tripeptide permease DtpA;


:

Pssm-ID: 181969  Cd Length: 500  Bit Score: 928.78  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592    1 MSTANQKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWL 80
Cdd:PRK09584   1 MSTANQKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592   81 GDKVLGTKRVIMLGAIVLAIGYALVAWSGHDAGIVYMGMAAIAVGNGLFKANPSSLLSTCYEKNDPRLDGAFTMYYMSVN 160
Cdd:PRK09584  81 GDKVLGTKRVIMLGAIVLAIGYALVAWSGHDAGIVYMGMATIAVGNGLFKANPSSLLSTCYEKDDPRLDGAFTMYYMSIN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  161 IGSFFSMIATPWLAAKYGWSVAFALSVVGLLITIVNFAFCQRWVKQYGSKPDFEPINYRNLLLTIIGVVALIAIATWLLH 240
Cdd:PRK09584 161 IGSFFSMLATPWLAAKYGWSVAFALSVVGMLITVVNFAFCQRWVKQYGSKPDFEPINYRKLLLTIVGVVALIAIATWLLH 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  241 NQEVARMALGVVAFGIVVIFGKEAFAMKGAARRKMIVAFILMLEAIIFFVLYSQMPTSLNFFAIRNVEHSILGLAVEPEQ 320
Cdd:PRK09584 241 NQEIARMALGVVALGIVVIFGKEAFAMKGAARRKMIVAFILMLEAIIFFVLYSQMPTSLNFFAIRNVEHSILGIAVEPEQ 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  321 YQALNPFWIIIGSPILAAIYNKMGDTLPMPTKFAIGMVMCSGAFLILPLGAKFASDAGIVSVSWLVASYGLQSIGELMIS 400
Cdd:PRK09584 321 YQALNPFWIMIGSPILAAIYNKMGDRLPMPHKFAIGMVLCSGAFLVLPLGAKFANDAGIVSVNWLIASYGLQSIGELMIS 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  401 GLGLAMVAQLVPQRLMGFIMGSWFLTTAGANLIGGYVAGMMAVPDNVTDPLMSLEVYGRVFLQIGVATAVIAVLMLLTAP 480
Cdd:PRK09584 401 GLGLAMVAQLVPQRLMGFIMGSWFLTTAGAALIAGYVANLMAVPDNVTDPLMSLEVYGRVFLQIGIATAVIAVLMLLTAP 480

                 ....*..
gi 16129592  481 KLHRMTQ 487
Cdd:PRK09584 481 KLNRMTQ 487
 
Name Accession Description Interval E-value
tppB PRK09584
dipeptide/tripeptide permease DtpA;
1-487 0e+00

dipeptide/tripeptide permease DtpA;


Pssm-ID: 181969  Cd Length: 500  Bit Score: 928.78  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592    1 MSTANQKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWL 80
Cdd:PRK09584   1 MSTANQKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592   81 GDKVLGTKRVIMLGAIVLAIGYALVAWSGHDAGIVYMGMAAIAVGNGLFKANPSSLLSTCYEKNDPRLDGAFTMYYMSVN 160
Cdd:PRK09584  81 GDKVLGTKRVIMLGAIVLAIGYALVAWSGHDAGIVYMGMATIAVGNGLFKANPSSLLSTCYEKDDPRLDGAFTMYYMSIN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  161 IGSFFSMIATPWLAAKYGWSVAFALSVVGLLITIVNFAFCQRWVKQYGSKPDFEPINYRNLLLTIIGVVALIAIATWLLH 240
Cdd:PRK09584 161 IGSFFSMLATPWLAAKYGWSVAFALSVVGMLITVVNFAFCQRWVKQYGSKPDFEPINYRKLLLTIVGVVALIAIATWLLH 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  241 NQEVARMALGVVAFGIVVIFGKEAFAMKGAARRKMIVAFILMLEAIIFFVLYSQMPTSLNFFAIRNVEHSILGLAVEPEQ 320
Cdd:PRK09584 241 NQEIARMALGVVALGIVVIFGKEAFAMKGAARRKMIVAFILMLEAIIFFVLYSQMPTSLNFFAIRNVEHSILGIAVEPEQ 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  321 YQALNPFWIIIGSPILAAIYNKMGDTLPMPTKFAIGMVMCSGAFLILPLGAKFASDAGIVSVSWLVASYGLQSIGELMIS 400
Cdd:PRK09584 321 YQALNPFWIMIGSPILAAIYNKMGDRLPMPHKFAIGMVLCSGAFLVLPLGAKFANDAGIVSVNWLIASYGLQSIGELMIS 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  401 GLGLAMVAQLVPQRLMGFIMGSWFLTTAGANLIGGYVAGMMAVPDNVTDPLMSLEVYGRVFLQIGVATAVIAVLMLLTAP 480
Cdd:PRK09584 401 GLGLAMVAQLVPQRLMGFIMGSWFLTTAGAALIAGYVANLMAVPDNVTDPLMSLEVYGRVFLQIGIATAVIAVLMLLTAP 480

                 ....*..
gi 16129592  481 KLHRMTQ 487
Cdd:PRK09584 481 KLNRMTQ 487
PTR2 COG3104
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
17-487 8.97e-170

Dipeptide/tripeptide permease [Amino acid transport and metabolism];


Pssm-ID: 442338 [Multi-domain]  Cd Length: 479  Bit Score: 487.40  E-value: 8.97e-170
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  17 FKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQL-----GMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVI 91
Cdd:COG3104  10 FGHPKGLYTLFFTEMWERFSFYGMRAILVLYLTASLadgglGLSEADAAAIYGAYTALVYLTPLLGGWLADRLLGQRRAI 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  92 MLGAIVLAIGYALVAWSGHDAGiVYMGMAAIAVGNGLFKANPSSLLSTCYEKNDPRLDGAFTMYYMSVNIGSFFSMIATP 171
Cdd:COG3104  90 LLGGILMALGHFLLALPGGVTL-FYLGLALIAVGNGLFKPNISSLVGQLYDPGDPRRDAGFTIFYMGINIGAFLAPLLCG 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 172 WLAAKYGWSVAFALSVVGLLITIVNFAFCQRWVKQYGSKPDFEPINYRNLLLTIIGVVALIAIATWLLHNQEVARMALGV 251
Cdd:COG3104 169 YLGEKYGWHYGFGAAAIGMLIGLIIFLLGRKYLGDIGLEPDNPLSKKERLIAVALGALLLVLVLAGLLSNANIANYLLYV 248
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 252 VAFGIVVIFGKEAFAMKGAARRKMIVAFILMLEAIIFFVLYSQMPTSLNFFAIRNVEHSILGLAVEPEQYQALNPFWIII 331
Cdd:COG3104 249 IAIIAYFIFILRSKKLTKEERKRLLAILILFLFSIVFWALYEQAGTSLNLFADRNVDRSLFGFEIPPSWFQSLNPLFIII 328
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 332 GSPILAAIYNKMGD---TLPMPTKFAIGMVMCSGAFLILPLGAKFASDAGIVSVSWLVASYGLQSIGELMISGLGLAMVA 408
Cdd:COG3104 329 LAPVFAALWTKLGKrgkEPSTPTKFALGLLLLGLGFLVMALAALLAGAGGKVSPLWLVLAYLLLTIGELCLSPVGLSMIT 408
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16129592 409 QLVPQRLMGFIMGSWFLTTAGANLIGGYVAGMMAVPDnvtdplmslevYGRVFLQIGVATAVIAVLMLLTAPKLHRMTQ 487
Cdd:COG3104 409 KLAPARFAGQMMGLWFLATALGNLLAGLLAGLYAVPG-----------YTAYFLLLGGIALVAGVVLLLLSPKLRRLMH 476
MFS_DtpA_like cd17346
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ...
20-481 9.21e-141

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340904 [Multi-domain]  Cd Length: 399  Bit Score: 410.43  E-value: 9.21e-141
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  20 PKAFYLIFSIELWERFGYYGLQGIMAVYLVKQL--GMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIV 97
Cdd:cd17346   1 PKGLYTLFFTEMWERFSYYGMRAILILYLTAQLgdGFSEADAASIYGAYTALVYLTPIIGGWLADKVLGARRTVFIGGIL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  98 LAIGYALVAWSGHDAGIVYMGMAAIAVGNGLFKANPSSLLSTCYEKNDPRLDGAFTMYYMSVNIGSFFSMIATPWLAAKY 177
Cdd:cd17346  81 MALGYLLLALSPFSVSMLYLGLALIIVGNGLFKPNISSLVGKLYDENDPRRDSGFSIFYMGINLGAFLAPLLCGTLGDNY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 178 GWSVAFALSVVGLLITIVNFAFCQRWVKQygskpdfepinyrnllltiigvvaliaiatwllhnqevarmalgvvafgiv 257
Cdd:cd17346 161 GYHYGFGLAAVGMLLGLLIFLLGRKKLLE--------------------------------------------------- 189
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 258 vifgkeafamkgaaRRKMIVAFILMLEAIIFFVLYSQMPTSLNFFAIRNVEHSILGLAVEPEQYQALNPFWIIIGSPILA 337
Cdd:cd17346 190 --------------RKKMLAIIILFLFAVVFWAIYEQAGTSLALFADENVDRLLGGFTIPPSWFQSLNPLFIILLAPILA 255
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 338 AIYNKMG---DTLPMPTKFAIGMVMCSGAFLILPLGAKFASDAGIVSVSWLVASYGLQSIGELMISGLGLAMVAQLVPQR 414
Cdd:cd17346 256 ALWTKLGkrgKDPSIPTKFALGLLLLGLSFLLMVLAASFAGGSGKVSALWLVLSYFLQTLGELCLSPVGLSMITKLAPAK 335
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16129592 415 LMGFIMGSWFLTTAGANLIGGYVAGMMAVPDnvtDPLMSLEVYGRVFLQIGVATAVIAVLMLLTAPK 481
Cdd:cd17346 336 FAGFMMGLWFLASALGNILAGYLAGFYAQPK---DPLASALVYTDYFGLIGVIALVAGIILLLLAKK 399
yjdL_sub1_fam TIGR00924
amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes ...
17-485 3.76e-119

amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes proton-dependent oligopeptide transporters in bacteria. This model is restricted in its range in recognizing bacterial proton-dependent oligopeptide transporters, although they are found in yeast, plants and animals. They function by proton symport in a 1:1 stoichiometry, which is variable in different species. All of them are predicted to contain 12 transmembrane domains, for which limited experimental evidence exists. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273342 [Multi-domain]  Cd Length: 475  Bit Score: 358.38  E-value: 3.76e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592    17 FKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQ--LGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLG 94
Cdd:TIGR00924   6 FGHPKPLFTLFFVELWERFSYYGMQGILAVYLVQQagLGFSQEQAFIIFGAYSALVYLLTSVGWWFGDRVWGTKKTMVLG 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592    95 AIVLAIGYALVAWSGHDAGIvYMGMAAIAVGNGLFKANPSSLLSTCYEKND-PRLDGAFTMYYMSVNIGSFFSMIATPWL 173
Cdd:TIGR00924  86 GIVLMLGHFMLAMSIYPDLI-FYGLGTIAVGSGLFKANPSSMVGKLYERGDmPRRDGGFTLFYMSINIGSFISPLLAGVI 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592   174 AAKYGWSVAFALSVVGLLITIVNFAFCQRWVKQYGSKPD---FEPINYRNLLLTIIGVVALIAIATWLLHNQEVARMALG 250
Cdd:TIGR00924 165 AENYGYHVGFNLAAVGMVIGLLTFFAGRHMLRDIGSVPDplsGQGKTYGKLLLALLAALALVFFCAWLMHHVVIANILLM 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592   251 VVAFGIVVIFGKEAF--AMKGAARRKMIVAFILMLEAIIFFVLYSQMPTSLNFFAIRNVEHSILGLAVEPEQYQALNPFW 328
Cdd:TIGR00924 245 TVTLAVIIFFFRLAFkpRLDAVARNKMYAYIVLFLEAVVFWVLYAQMPTSLNFFADNNMHHEMLGMSVPVIWFQSLNPFW 324
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592   329 IIIGSPILAAIYNKMGDT---LPMPTKFAIGMVMCSGAFLILPLGAKFASDAGIVSVSWLVASYGLQSIGELMISGLGLA 405
Cdd:TIGR00924 325 VVVGSPVLAMIWTRLGRKgkdPTTPLKFTLGMLFCGASFLTFAASIWFADAGGLTSPWFMVLIYLFQTLGELMISPLGLS 404
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592   406 MVAQLVPQRLMGFIMGSWFLTTAGANLIGGYVAGMMAVPDNVTDplmslevygrVFLQIGVATAVIAVLMLLTAPKLHRM 485
Cdd:TIGR00924 405 WWTKIAPQRLMGQMLGMWFLAQAMGSLLGGYLATFGAVPQGVTG----------VFGKIGLVTLLVGVVMALMVPWLNRM 474
PTR2 pfam00854
POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton ...
88-447 8.97e-103

POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.


Pssm-ID: 425909 [Multi-domain]  Cd Length: 392  Bit Score: 313.10  E-value: 8.97e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592    88 KRVIMLGAIVLAIGYALVAWSGHDAG-------IVYMGMAAIAVGNGLFKANPSSLLSTCYEKNDPRLDGA-FTMYYMSV 159
Cdd:pfam00854   1 FRTIFLGSIIYAIGHILLALSAIPSLrppvhvaLFFIGLALIALGTGGIKPNVSSFGGDQFEETDPRRRSRfFSIFYFSI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592   160 NIGSFFSMIATPWLAAKYGWSVAFALSVVGLLITIVNFAFCQRWVKQYGSKPDFEPINYRNLLLTI------IGVVALIA 233
Cdd:pfam00854  81 NAGSLISTIITPYLQQNYGYPLGFGLPAVGMIIALLVFLLGSRMYKKKPPKGNVLTKVFKVLPVAAwnkvklNGSSAGIK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592   234 IATWLLHNQEV-ARMALGVVAFGIVVIFGkeAFAMKGAARRKMIVAFILMLEAIIFFVLYSQMPTSLNFFAiRNVEHSIL 312
Cdd:pfam00854 161 KLHWLDWARELdALIILGIVVPGIFFNIW--CTKTKVEEVKRLLRVLPLFLPLIMFWALYDQMGTSWVLQA-RTMNRKIG 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592   313 GLAVEPEQYQALNPFWIIIGSPILAAIYNKMGD----TLPMPTKFAIGMVMCSGAFLILPLGAKFASDAG---------I 379
Cdd:pfam00854 238 SFEIPPAQFQAFNAILVLIFIPIFDRLVYPLGRkctgGLTPLQKMAVGLFLASLAFAIAAIVQLKRNDTGpefpiaqevP 317
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16129592   380 VSVSWLVASYGLQSIGELMISGLGLAMVAQLVPQRLMGFIMGSWFLTTAGANLIGGYVAGMMAVPDNV 447
Cdd:pfam00854 318 ISVLWLIPQYLLIGFGELFISIGGLEFFYKLAPKSMTSLITGLFLLTNALGNFLSGVIATLTAKPTNV 385
 
Name Accession Description Interval E-value
tppB PRK09584
dipeptide/tripeptide permease DtpA;
1-487 0e+00

dipeptide/tripeptide permease DtpA;


Pssm-ID: 181969  Cd Length: 500  Bit Score: 928.78  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592    1 MSTANQKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWL 80
Cdd:PRK09584   1 MSTANQKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592   81 GDKVLGTKRVIMLGAIVLAIGYALVAWSGHDAGIVYMGMAAIAVGNGLFKANPSSLLSTCYEKNDPRLDGAFTMYYMSVN 160
Cdd:PRK09584  81 GDKVLGTKRVIMLGAIVLAIGYALVAWSGHDAGIVYMGMATIAVGNGLFKANPSSLLSTCYEKDDPRLDGAFTMYYMSIN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  161 IGSFFSMIATPWLAAKYGWSVAFALSVVGLLITIVNFAFCQRWVKQYGSKPDFEPINYRNLLLTIIGVVALIAIATWLLH 240
Cdd:PRK09584 161 IGSFFSMLATPWLAAKYGWSVAFALSVVGMLITVVNFAFCQRWVKQYGSKPDFEPINYRKLLLTIVGVVALIAIATWLLH 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  241 NQEVARMALGVVAFGIVVIFGKEAFAMKGAARRKMIVAFILMLEAIIFFVLYSQMPTSLNFFAIRNVEHSILGLAVEPEQ 320
Cdd:PRK09584 241 NQEIARMALGVVALGIVVIFGKEAFAMKGAARRKMIVAFILMLEAIIFFVLYSQMPTSLNFFAIRNVEHSILGIAVEPEQ 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  321 YQALNPFWIIIGSPILAAIYNKMGDTLPMPTKFAIGMVMCSGAFLILPLGAKFASDAGIVSVSWLVASYGLQSIGELMIS 400
Cdd:PRK09584 321 YQALNPFWIMIGSPILAAIYNKMGDRLPMPHKFAIGMVLCSGAFLVLPLGAKFANDAGIVSVNWLIASYGLQSIGELMIS 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  401 GLGLAMVAQLVPQRLMGFIMGSWFLTTAGANLIGGYVAGMMAVPDNVTDPLMSLEVYGRVFLQIGVATAVIAVLMLLTAP 480
Cdd:PRK09584 401 GLGLAMVAQLVPQRLMGFIMGSWFLTTAGAALIAGYVANLMAVPDNVTDPLMSLEVYGRVFLQIGIATAVIAVLMLLTAP 480

                 ....*..
gi 16129592  481 KLHRMTQ 487
Cdd:PRK09584 481 KLNRMTQ 487
PRK10207 PRK10207
dipeptide/tripeptide permease DtpB;
11-485 1.58e-177

dipeptide/tripeptide permease DtpB;


Pssm-ID: 182306  Cd Length: 489  Bit Score: 507.82  E-value: 1.58e-177
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592   11 SVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRV 90
Cdd:PRK10207   4 TAPMGLLQQPRPFFMIFFVELWERFGYYGVQGILAVFFVKQLGFSQEQAFITFGAFAALVYGLISIGGYVGDHLLGTKRT 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592   91 IMLGAIVLAIGYALVAWSGHDAGIVYMGMAAIAVGNGLFKANPSSLLSTCYEKNDPRLDGAFTMYYMSVNIGSFFSMIAT 170
Cdd:PRK10207  84 IVLGAIVLAIGYFMTGMSLLKPDLIFIALGTIAVGNGLFKANPASLLSKCYPPKDPRLDGAFTLFYMSINIGSLISLSLA 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  171 PWLAAKYGWSVAFALSVVGLLITIVNFAFCQRWVKQYGSKPDFEPINYRNLLLTIIGVVALIAIATWLLHNQEVARMALG 250
Cdd:PRK10207 164 PVIADKFGYSVTYNLCGAGLIIALLVYFACRGMVKDIGSEPDHKPMSFSKLLLVLLGSVVMIFVCAWLMHNVEVANLVLI 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  251 VVAFGIVVIFGKEAFAMKGAARRKMIVAFILMLEAIIFFVLYSQMPTSLNFFAIRNVEHSILGLAVEPEQYQALNPFWII 330
Cdd:PRK10207 244 VLSIVVTIIFFREAFKLDKTGRNKMFVAFVLMLEAVVFYILYAQMPTSLNFFAINNVHHEILGFSINPVSFQALNPFWVV 323
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  331 IGSPILAAIYNKMGDT---LPMPTKFAIGMVMCSGAFLILPL-GAKFASDAGIVSVSWLVASYGLQSIGELMISGLGLAM 406
Cdd:PRK10207 324 VASPILAGIYTHLGSKgkdLSMPMKFTLGMFLCSLGFLTAAAaGMWFADAQGLTSPWFIVLVYLFQSLGELFISALGLAM 403
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16129592  407 VAQLVPQRLMGFIMGSWFLTTAGANLIGGYVAGMMAVPDNVTDPLMSLEVYGRVFLQIGVATAVIAVLMLLTAPKLHRM 485
Cdd:PRK10207 404 IAALVPQHLMGFILGMWFLTQAAAFLLGGYVATFTAVPDNITDPLETLPVYTNVFGKIGLVTLGVAVVMALMVPWLNRM 482
PTR2 COG3104
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
17-487 8.97e-170

Dipeptide/tripeptide permease [Amino acid transport and metabolism];


Pssm-ID: 442338 [Multi-domain]  Cd Length: 479  Bit Score: 487.40  E-value: 8.97e-170
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  17 FKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQL-----GMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVI 91
Cdd:COG3104  10 FGHPKGLYTLFFTEMWERFSFYGMRAILVLYLTASLadgglGLSEADAAAIYGAYTALVYLTPLLGGWLADRLLGQRRAI 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  92 MLGAIVLAIGYALVAWSGHDAGiVYMGMAAIAVGNGLFKANPSSLLSTCYEKNDPRLDGAFTMYYMSVNIGSFFSMIATP 171
Cdd:COG3104  90 LLGGILMALGHFLLALPGGVTL-FYLGLALIAVGNGLFKPNISSLVGQLYDPGDPRRDAGFTIFYMGINIGAFLAPLLCG 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 172 WLAAKYGWSVAFALSVVGLLITIVNFAFCQRWVKQYGSKPDFEPINYRNLLLTIIGVVALIAIATWLLHNQEVARMALGV 251
Cdd:COG3104 169 YLGEKYGWHYGFGAAAIGMLIGLIIFLLGRKYLGDIGLEPDNPLSKKERLIAVALGALLLVLVLAGLLSNANIANYLLYV 248
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 252 VAFGIVVIFGKEAFAMKGAARRKMIVAFILMLEAIIFFVLYSQMPTSLNFFAIRNVEHSILGLAVEPEQYQALNPFWIII 331
Cdd:COG3104 249 IAIIAYFIFILRSKKLTKEERKRLLAILILFLFSIVFWALYEQAGTSLNLFADRNVDRSLFGFEIPPSWFQSLNPLFIII 328
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 332 GSPILAAIYNKMGD---TLPMPTKFAIGMVMCSGAFLILPLGAKFASDAGIVSVSWLVASYGLQSIGELMISGLGLAMVA 408
Cdd:COG3104 329 LAPVFAALWTKLGKrgkEPSTPTKFALGLLLLGLGFLVMALAALLAGAGGKVSPLWLVLAYLLLTIGELCLSPVGLSMIT 408
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16129592 409 QLVPQRLMGFIMGSWFLTTAGANLIGGYVAGMMAVPDnvtdplmslevYGRVFLQIGVATAVIAVLMLLTAPKLHRMTQ 487
Cdd:COG3104 409 KLAPARFAGQMMGLWFLATALGNLLAGLLAGLYAVPG-----------YTAYFLLLGGIALVAGVVLLLLSPKLRRLMH 476
MFS_DtpA_like cd17346
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ...
20-481 9.21e-141

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340904 [Multi-domain]  Cd Length: 399  Bit Score: 410.43  E-value: 9.21e-141
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  20 PKAFYLIFSIELWERFGYYGLQGIMAVYLVKQL--GMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIV 97
Cdd:cd17346   1 PKGLYTLFFTEMWERFSYYGMRAILILYLTAQLgdGFSEADAASIYGAYTALVYLTPIIGGWLADKVLGARRTVFIGGIL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  98 LAIGYALVAWSGHDAGIVYMGMAAIAVGNGLFKANPSSLLSTCYEKNDPRLDGAFTMYYMSVNIGSFFSMIATPWLAAKY 177
Cdd:cd17346  81 MALGYLLLALSPFSVSMLYLGLALIIVGNGLFKPNISSLVGKLYDENDPRRDSGFSIFYMGINLGAFLAPLLCGTLGDNY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 178 GWSVAFALSVVGLLITIVNFAFCQRWVKQygskpdfepinyrnllltiigvvaliaiatwllhnqevarmalgvvafgiv 257
Cdd:cd17346 161 GYHYGFGLAAVGMLLGLLIFLLGRKKLLE--------------------------------------------------- 189
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 258 vifgkeafamkgaaRRKMIVAFILMLEAIIFFVLYSQMPTSLNFFAIRNVEHSILGLAVEPEQYQALNPFWIIIGSPILA 337
Cdd:cd17346 190 --------------RKKMLAIIILFLFAVVFWAIYEQAGTSLALFADENVDRLLGGFTIPPSWFQSLNPLFIILLAPILA 255
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 338 AIYNKMG---DTLPMPTKFAIGMVMCSGAFLILPLGAKFASDAGIVSVSWLVASYGLQSIGELMISGLGLAMVAQLVPQR 414
Cdd:cd17346 256 ALWTKLGkrgKDPSIPTKFALGLLLLGLSFLLMVLAASFAGGSGKVSALWLVLSYFLQTLGELCLSPVGLSMITKLAPAK 335
                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16129592 415 LMGFIMGSWFLTTAGANLIGGYVAGMMAVPDnvtDPLMSLEVYGRVFLQIGVATAVIAVLMLLTAPK 481
Cdd:cd17346 336 FAGFMMGLWFLASALGNILAGYLAGFYAQPK---DPLASALVYTDYFGLIGVIALVAGIILLLLAKK 399
yjdL_sub1_fam TIGR00924
amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes ...
17-485 3.76e-119

amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes proton-dependent oligopeptide transporters in bacteria. This model is restricted in its range in recognizing bacterial proton-dependent oligopeptide transporters, although they are found in yeast, plants and animals. They function by proton symport in a 1:1 stoichiometry, which is variable in different species. All of them are predicted to contain 12 transmembrane domains, for which limited experimental evidence exists. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273342 [Multi-domain]  Cd Length: 475  Bit Score: 358.38  E-value: 3.76e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592    17 FKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQ--LGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLG 94
Cdd:TIGR00924   6 FGHPKPLFTLFFVELWERFSYYGMQGILAVYLVQQagLGFSQEQAFIIFGAYSALVYLLTSVGWWFGDRVWGTKKTMVLG 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592    95 AIVLAIGYALVAWSGHDAGIvYMGMAAIAVGNGLFKANPSSLLSTCYEKND-PRLDGAFTMYYMSVNIGSFFSMIATPWL 173
Cdd:TIGR00924  86 GIVLMLGHFMLAMSIYPDLI-FYGLGTIAVGSGLFKANPSSMVGKLYERGDmPRRDGGFTLFYMSINIGSFISPLLAGVI 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592   174 AAKYGWSVAFALSVVGLLITIVNFAFCQRWVKQYGSKPD---FEPINYRNLLLTIIGVVALIAIATWLLHNQEVARMALG 250
Cdd:TIGR00924 165 AENYGYHVGFNLAAVGMVIGLLTFFAGRHMLRDIGSVPDplsGQGKTYGKLLLALLAALALVFFCAWLMHHVVIANILLM 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592   251 VVAFGIVVIFGKEAF--AMKGAARRKMIVAFILMLEAIIFFVLYSQMPTSLNFFAIRNVEHSILGLAVEPEQYQALNPFW 328
Cdd:TIGR00924 245 TVTLAVIIFFFRLAFkpRLDAVARNKMYAYIVLFLEAVVFWVLYAQMPTSLNFFADNNMHHEMLGMSVPVIWFQSLNPFW 324
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592   329 IIIGSPILAAIYNKMGDT---LPMPTKFAIGMVMCSGAFLILPLGAKFASDAGIVSVSWLVASYGLQSIGELMISGLGLA 405
Cdd:TIGR00924 325 VVVGSPVLAMIWTRLGRKgkdPTTPLKFTLGMLFCGASFLTFAASIWFADAGGLTSPWFMVLIYLFQTLGELMISPLGLS 404
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592   406 MVAQLVPQRLMGFIMGSWFLTTAGANLIGGYVAGMMAVPDNVTDplmslevygrVFLQIGVATAVIAVLMLLTAPKLHRM 485
Cdd:TIGR00924 405 WWTKIAPQRLMGQMLGMWFLAQAMGSLLGGYLATFGAVPQGVTG----------VFGKIGLVTLLVGVVMALMVPWLNRM 474
PTR2 pfam00854
POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton ...
88-447 8.97e-103

POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.


Pssm-ID: 425909 [Multi-domain]  Cd Length: 392  Bit Score: 313.10  E-value: 8.97e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592    88 KRVIMLGAIVLAIGYALVAWSGHDAG-------IVYMGMAAIAVGNGLFKANPSSLLSTCYEKNDPRLDGA-FTMYYMSV 159
Cdd:pfam00854   1 FRTIFLGSIIYAIGHILLALSAIPSLrppvhvaLFFIGLALIALGTGGIKPNVSSFGGDQFEETDPRRRSRfFSIFYFSI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592   160 NIGSFFSMIATPWLAAKYGWSVAFALSVVGLLITIVNFAFCQRWVKQYGSKPDFEPINYRNLLLTI------IGVVALIA 233
Cdd:pfam00854  81 NAGSLISTIITPYLQQNYGYPLGFGLPAVGMIIALLVFLLGSRMYKKKPPKGNVLTKVFKVLPVAAwnkvklNGSSAGIK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592   234 IATWLLHNQEV-ARMALGVVAFGIVVIFGkeAFAMKGAARRKMIVAFILMLEAIIFFVLYSQMPTSLNFFAiRNVEHSIL 312
Cdd:pfam00854 161 KLHWLDWARELdALIILGIVVPGIFFNIW--CTKTKVEEVKRLLRVLPLFLPLIMFWALYDQMGTSWVLQA-RTMNRKIG 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592   313 GLAVEPEQYQALNPFWIIIGSPILAAIYNKMGD----TLPMPTKFAIGMVMCSGAFLILPLGAKFASDAG---------I 379
Cdd:pfam00854 238 SFEIPPAQFQAFNAILVLIFIPIFDRLVYPLGRkctgGLTPLQKMAVGLFLASLAFAIAAIVQLKRNDTGpefpiaqevP 317
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16129592   380 VSVSWLVASYGLQSIGELMISGLGLAMVAQLVPQRLMGFIMGSWFLTTAGANLIGGYVAGMMAVPDNV 447
Cdd:pfam00854 318 ISVLWLIPQYLLIGFGELFISIGGLEFFYKLAPKSMTSLITGLFLLTNALGNFLSGVIATLTAKPTNV 385
PRK15462 PRK15462
dipeptide permease;
19-442 1.02e-53

dipeptide permease;


Pssm-ID: 237971 [Multi-domain]  Cd Length: 493  Bit Score: 188.23  E-value: 1.02e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592   19 QPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVL 98
Cdd:PRK15462   7 QPRAIYYVVALQIWEYFSFYGMRALLILYLTNQLKYDDNHAYELFSAYCSLVYVTPILGGFLADKVLGNRMAVMLGALLM 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592   99 AIGYALVAWSGHDAGIVYMGMAAIAVGNGLFKANPSSLLSTCYEKNDPRLDGAFTMYYMSVNIGSFFSMIATPWLAAKYG 178
Cdd:PRK15462  87 AIGHVVLGASEIHPSFLYLSLAIIVCGYGLFKSNVSCLLGELYEPTDPRRDGGFSLMYAAGNVGSIIAPIACGYAQEEYS 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  179 WSVAFALSVVGLLITIVNFAFCQRWV-------KQYGSKPDFEPINYRNLLLTIIGVVALIAIATWllhnQEVARMALGV 251
Cdd:PRK15462 167 WAMGFGLAAVGMIAGLVIFLCGNRHFthtrgvnKKVLRATNFLLPNWGWLLVLLVATPALITVLFW----KEWSVYALIV 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  252 -VAFGIVVIFGKEAFAMKGAARRKMIVAFILMLEAIIFFVLYSQMPTSLNFFAIRNVEHSILGLAVEPEQYQALNPFWII 330
Cdd:PRK15462 243 aTIIGLGVLAKIYRKAENQKQRKELGLIVTLTFFSMLFWAFAQQGGSSISLYIDRFVNRDMFGYTVPTAMFQSINAFAVM 322
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  331 IGSPILA-AIYNKMGD--TLPMPTKFAIGMVMCSGAFLILPLGAKFASDAGIVSVSWLVASYGLQSIGELMISGLGLAMV 407
Cdd:PRK15462 323 LCGVFLAwVVKESVAGnrTVRIWGKFALGLGLMSAGFCILTLSARWSAMYGHSSLPLMVLGLAVMGFAELFIDPVAMSQI 402
                        410       420       430
                 ....*....|....*....|....*....|....*
gi 16129592  408 AQLVPQRLMGFIMGSWFLTTAGanlIGGYVAGMMA 442
Cdd:PRK15462 403 TRIEIPGVTGVLTGIYMLLSGA---IANYLAGVIA 434
MFS_POT cd06175
Proton-coupled oligopeptide transporter (POT) family of the Major Facilitator Superfamily of ...
23-481 5.14e-46

Proton-coupled oligopeptide transporter (POT) family of the Major Facilitator Superfamily of transporters; The Proton-coupled oligopeptide transporter (POT) family is present across all major kingdoms of life and is known by a variety of names. It is referred to as the Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) in plants, and in addition to POT, it is also known as the Peptide transporter (PepT/PTR) or Solute Carrier 15 (SLC15) family in animals. Members of this family are proton-driven symporters involved in nitrogen acquisition in the form of di- and tripeptides. Plant members transport other nitrogenous ligands including nitrate, the plant hormone auxin, and glucosinolate compounds that are important for seed defense. POT proteins exhibit substrate multispecificity, with one transporter able to recognize as many as 8,400 types of di/tripeptides and certain peptide-like drugs. The POT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340865 [Multi-domain]  Cd Length: 422  Bit Score: 165.69  E-value: 5.14e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  23 FYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLAIGY 102
Cdd:cd06175   1 CAMILLIELCERFTFYGIGANLVPFLTGALGLGNAQAANVVLNFLGTSYVTPLFGGWIADTFLGRYRTILIGAAIYAVGV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 103 ALVAWSGHDAG--------------------IVYMGMAAIAVGNGLFKANPSSLLSTCYEKNDP-RLDGAFTMYYMSVNI 161
Cdd:cd06175  81 AILTVSTIPPGlrplrcnpshceqasgiqltGFYAALYLIALGTGGVKANVSPLGADQFDERGPsKTQSFFNWFYFCINV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 162 GSFFSMIATPWLAAKYGWSVAFALSVVGLLITIVNFAfcqrwvkqygskpdfepinyrnllltiigvvaliaiatwllhn 241
Cdd:cd06175 161 GSLLAMLGTPYIQDNVGWAAAYGIPFVAILLALVVFE------------------------------------------- 197
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 242 qevarmalgvvafgivvifgkeafamkgaaRRKMIVAFILMLEAIIFFVLYSQMPTSLNFFAIRNVEhSILGLAVEPEQY 321
Cdd:cd06175 198 ------------------------------VKQLLRALPLFAFCILFWTVYAQMTTSYVLQALTLVR-STGLFTIPPASM 246
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 322 QALNPFWIIIGSPILAAIYNKMGDTLPMP----TKFAIGMVMCSGAFLILPLGAKFASDAGI----------VSVSWLVA 387
Cdd:cd06175 247 QAFNPILLLLLIPVLDKVVYPLIRRYGVGlsplTKIGLGFFFGSLSMFVAGFLELKRLNTAHahgpvvttspLSFWWQIP 326
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 388 SYGLQSIGELMISGLGLAMVAQLVPQRLMGFIMGSWFLTTAGANLIGGYVAGMMAVPD--NVTDPLMSLEVYGRVFLQIG 465
Cdd:cd06175 327 QYLLLGIGEILVSITGLEFAYREAPKSMKGFIMGLLLLTSGFGSFFGSVLVTLVSKPTdgAHIADDLNKGVLTNFFFLLA 406
                       490
                ....*....|....*.
gi 16129592 466 VATAVIAVLMLLTAPK 481
Cdd:cd06175 407 VLAALNFLIFLLVSRK 422
MFS_SLC15A1_2_like cd17347
Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily ...
20-475 5.45e-38

Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily transporters; Solute carrier family 15 member 1 (SLC15A1) and SLC15A2 are members of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. They mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A1, or peptide transporter 1 (PepT1), is primarily expressed in the brush border membranes of enterocytes of the small intestine and is also known as the intestinal isoform. SLC15A2, or peptide transporter 2 (PepT2), is abundantly expressed in the apical membrane of kidney proximal tubules and is also referred to as the renal isoform. Both proteins transport di/tripeptides, but not tetrapeptides or free amino acids, using the energy generated by an inwardly directed transmembrane proton gradient. The SLC15A1/SLC15A2-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340905 [Multi-domain]  Cd Length: 427  Bit Score: 143.91  E-value: 5.45e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  20 PKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLA 99
Cdd:cd17347   1 PRAVPFIVGNEFCERFSYYGMRAILVLYLTDFLGFSEAEATAIYHSFVMLCYFFPLLGAIIADSYLGKYRTILYLSLVYC 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 100 IGYALVAWSGHDAGI------VYMGMAAIAVGNGLFKANPSSLLSTCY-EKNDPRLDGAFTMYYMSVNIGSFFSMIATPW 172
Cdd:cd17347  81 LGHIVLAVTAIPPLGpphvwgLLIGLLLIAIGTGGIKPCVSAFGGDQFgADQQHLLARFFSWFYFAINAGSLLSTFLTPI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 173 LAA------KYGWSVAFALSVVgllitivnfafcqrwvkqygskpdfepinyrnllltiigvvaLIAIATwllhnqevar 246
Cdd:cd17347 161 LRAdvqfggHDCYPLAFGVPGV------------------------------------------LMAVAT---------- 188
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 247 malgvvafgIVVIFGKEAFAMKGAARRkMIVAFILMleaIIFFVLYSQMPTSLNFFAIRnVEHSILGLAVEPEQYQALNP 326
Cdd:cd17347 189 ---------LVFWLGRKHYKDVKALLR-VLVLFIPL---PVFWALFDQQGSRWTLQAEQ-MDGLVGGFTILPDQMQALNP 254
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 327 FWIIIGSPILAA-IY---NKMGDTLPMPTKFAIGMVMCSGAFLI-------LPLGAKFASDAGI-----------VSVSW 384
Cdd:cd17347 255 ILILILIPLFDYvIYpllERCGIPLTPLRKMGVGMILAALAFVIagflqlrIDGGLPGQPDPGEvttfediepnsVSILW 334
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 385 LVASYGLQSIGELMISGLGLAMVAQLVPQRLMGFIMGSWFLTTAGANLIGGYVAGMMAVPDNVTdplmslevYGRVFLQI 464
Cdd:cd17347 335 QLPQYVVLTAGEVLFSITGLEFAYTQAPKSMKSVVQAAWLLTVALGNLIVVIVAELIQFSSQAA--------EYFFFAGL 406
                       490
                ....*....|.
gi 16129592 465 GVATAVIAVLM 475
Cdd:cd17347 407 MLVVAVVFALL 417
MFS_SLC15A1 cd17412
Solute Carrier family 15 member 1 of the Major Facilitator Superfamily of transporters; Solute ...
20-445 6.98e-17

Solute Carrier family 15 member 1 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 1 (SLC15A1), also called peptide transporter 1 (PepT1), is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. SLC15A1, as well as SLC15A2, mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A1 is primarily expressed in the brush border membranes of enterocytes of the small intestine and is also known as the intestinal isoform. It is a high-capacity/low-affinity transporter that drives the transport of di-and tripeptides for metabolic purposes. It's expression is upregulated in the colon during chronic inflammation associated with inflammatory bowel disease. SLC15A1/PepT1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340970 [Multi-domain]  Cd Length: 415  Bit Score: 82.58  E-value: 6.98e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  20 PKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLA 99
Cdd:cd17412   1 PLSIFFIVVNEFCERFSYYGMRAVLVLYFKYFLRWDDDLSTAIYHTFVALCYLTPILGAIIADSWLGKFKTIVYLSIVYT 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 100 IGYALVAWSG-HD----------------AGIVYMGMAAIAVGNGLFKANPSSLLSTCYEKN-DPRLDGAFTMYYMSVNI 161
Cdd:cd17412  81 IGQAVMAVSAiHDltdanrdgtpdnltlhVALSMIGLLLIALGTGGIKPCVAAFGGDQFEEHqEKQRSRFFSIFYLSINA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 162 GSFFSMIATPWLAAKYgwsvafalsvvgllitivnfafCQRWVKQYGSKPDFepinyrnllltiiGVVAliaiatwllhn 241
Cdd:cd17412 161 GSLLSTIITPILRSQE----------------------CGIHSKQKCYPLAF-------------GVPA----------- 194
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 242 qevarmALGVVAFgIVVIFGKEAFamkgaARRKMIV-AFILMLEAIIFFVLYSQMPTSLNFFAIrNVEHSILGLAVEPEQ 320
Cdd:cd17412 195 ------ALMVVAL-IVFILGSKMY-----KQIKMVLkVLFLYIPLPMFWALFDQQGSRWTLQAT-TMDGNFGAIQIQPDQ 261
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 321 YQALNPFWIIIGSPIL-AAIY---NKMGDTLPMPTKFAIGMVMCSGAFLILPLGAkfasdagiVSVSWLVASYGLQSIGE 396
Cdd:cd17412 262 MQTVNPILIIIMVPIFdAVIYpliKKCKINFTPLRKMTVGMFLAALAFVAAALLQ--------IQMAWQIPQYFLLTCGE 333
                       410       420       430       440
                ....*....|....*....|....*....|....*....|....*....
gi 16129592 397 LMISGLGLAMVAQLVPQRLMGFIMGSWFLTTAGANLIGGYVAGMMAVPD 445
Cdd:cd17412 334 VVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIVAEAGSISE 382
2A1704 TIGR00926
Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and ...
35-366 3.85e-14

Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273343 [Multi-domain]  Cd Length: 654  Bit Score: 74.80  E-value: 3.85e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592    35 FGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLAIGYALVAWSG----- 109
Cdd:TIGR00926   1 FSYYGMRTILVLYFLNFLGFSESTSTVLFHTFTYLCYLTPLIGAIIADGWLGKFKTILYLSIVYVVGHALLSFGAipssg 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592   110 ---HDAgIVYMGMAAIAVGNGLFKANPSSLLSTCYEKNDPRLDGA-FTMYYMSVNIGSFFSMIATPWLAAKYG------- 178
Cdd:TIGR00926  81 hplHDL-LDLLGLALIALGTGGIKPCVSAFGGDQFEERQLSLRSRfFSFFYFAINAGSLISTIITPILRGDVGcfgcqdc 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592   179 WSVAFALSVVGLLITIVNFAFcqrWVKQYGSKPDFEPInyrnllltIIGVVALIAIA--------------TWLLHNQEV 244
Cdd:TIGR00926 160 YPLAFGVPAILMILALIVFMA---GSKMYKKKPPKGNI--------VSKVIKCIVTAlrkrfstrsehwplHWLDYAKDK 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592   245 ArmalgvvafGIVVIfgkeafamkgAARRKMIVAFILMLEAIIFFVLYSQMPTSLNFFAIRnVEHSILGLAVEPEQYQAL 324
Cdd:TIGR00926 229 H---------DIRMI----------RSTKRLLRVLVLFIPLPMFWALFDQQGSRWTLQATR-MDGDVGGFEIQPDQMQVV 288
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 16129592   325 NPFWIIIGSPI----LAAIYNKMGDTLPMPTKFAIGMVMCSGAFLI 366
Cdd:TIGR00926 289 NPLLILIFVPIfdyiVYPAIAKCGTRFTSLRKMAVGGLLAALSFFV 334
MFS_NPF cd17351
Plant NRT1/PTR family (NPF) of the Major Facilitator Superfamily of transporters; The plant ...
25-198 2.49e-13

Plant NRT1/PTR family (NPF) of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340909 [Multi-domain]  Cd Length: 445  Bit Score: 71.88  E-value: 2.49e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  25 LIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLAIGYAL 104
Cdd:cd17351   3 FILGNEFAERLAFYGIAVNLVTYLTKVMHLSNAKAANTVTNFSGTSYLTPLLGAFLADAYLGRYWTIAIFSVIYLVGLIL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 105 VAWS---------------------GHDAGIVYMGMAAIAVGNGLFKANPSSLLSTCYEKNDPR----LDGAFTMYYMSV 159
Cdd:cd17351  83 LTLSasvpslrpppcnpdspcepasSTQLTVLYVGLYLIALGTGGIKPCVSAFGADQFDETDPKekkqKPSFFNWFYFSI 162
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 16129592 160 NIGSFFSMIATPWLAAKYGWSVAFALSVVGLLITIVNFA 198
Cdd:cd17351 163 NLGSLLAVTLVVYIQDNVSWGWGFGIPAAAMALAVIVFV 201
MFS_NPF6 cd17413
NRT1/PTR family (NPF), subfamily 6 of the Major Facilitator Superfamily of transporters; The ...
25-197 2.31e-12

NRT1/PTR family (NPF), subfamily 6 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter 1/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF6 includes the first identified member of the NRT1/PTR family: Arabidopsis thaliana NRT1.1, now called AtNPF6.3. It is a dual affinity nitrate influx transporter and a nitrate sensor. It also transports auxin and has nitrate efflux activity. NPF6 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340971 [Multi-domain]  Cd Length: 457  Bit Score: 69.02  E-value: 2.31e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  25 LIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLAIGYAL 104
Cdd:cd17413   6 LILGIEMCERLTTLGIGVNLVTYLTGTMHLPSATSANIVTNFLGTSFLLCLLGGFIADTFLGRYLTIAIFASIQALGVLV 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 105 VAWS-----------------------GHDAGIVYMGMAAIAVGNGLFKANPSSLLSTCYEKNDPR----LDGAFTMYYM 157
Cdd:cd17413  86 LTLSttlpslrpppcnhttshhcepasGIQLTVLYLALYLIALGTGGIKSSVSGFGSDQFDENDPKerklMSYFFNRFFF 165
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 16129592 158 SVNIGSFFSMIATPWLAAKYGWSVAFALSVVGLLITIVNF 197
Cdd:cd17413 166 CISVGSLLAVTVLVYIQDNVGRGWGYGICAAAMVLAIVVF 205
MFS_NPF5 cd17417
NRT1/PTR family (NPF), subfamily 5 of the Major Facilitator Superfamily of transporters; The ...
21-197 5.88e-12

NRT1/PTR family (NPF), subfamily 5 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF5 includes Arabidopsis thaliana PTR3 (AtPTR3, now named AtNPF5.2), which is a wound-induced peptide transporter that is necessary for defense against virulent bacterial pathogens. NPF5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340975 [Multi-domain]  Cd Length: 452  Bit Score: 67.68  E-value: 5.88e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  21 KAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLAI 100
Cdd:cd17417   2 KACSFIIGIEVAERFAYYGIASNLVTYLTTPLHQSTARAAKNVNNWSGTATLLPLLGAFVADAYLGRYRTILISSLIYLL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 101 GYALVAWS----GHDA---------------GIVYMGMAAIAVGNGLFKANPSSLLSTCYEKNDPRLDGA----FTMYYM 157
Cdd:cd17417  82 GLVLLTLSaslpSLKPpecngtcskastlqvAFFFFSLYLVAIGQGGHKPCVQAFGADQFDEDDPKEKKQkssfFNWWYF 161
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 16129592 158 SVNIGSFFSMIATPWLAAKYGWSVAFALSVVGLLITIVNF 197
Cdd:cd17417 162 SICAGSLTAVTVLVYIQDNVGWALGFGIPTIVMALALFVF 201
MFS_NPF4 cd17414
NRT1/PTR family (NPF), subfamily 4 of the Major Facilitator Superfamily of transporters; The ...
21-198 6.00e-12

NRT1/PTR family (NPF), subfamily 4 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. Members of the NPF4 subfamily have been shown to transport ABA. NPF4 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340972 [Multi-domain]  Cd Length: 456  Bit Score: 67.43  E-value: 6.00e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  21 KAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLAI 100
Cdd:cd17414   2 RAAFFVLVVEALENMAYLANANNLVTYLINNMHYSLAKSANIVTNFVGTAFLLALLGGFLSDSFLSSFKTIIIFGSIELL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 101 GYALVAWSGH-----------------------DAGIVYMGMAAIAVGNGLFKANPSSLLSTCYEKNDP----RLDGAFT 153
Cdd:cd17414  82 GLILLTVQAHipslqppscnslgdltckepsgsQAAILFVGLYLVALGVGCIKPNLPSHGADQFDENDPkgrrQLSSFFN 161
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 16129592 154 MYYMSVNIGSFFSMIATPWLAAKYGWSVAFALSVVGLLITIVNFA 198
Cdd:cd17414 162 WYYFSFSLGALIAVTLVVWVEENKGWDWGFGVSAAVIAVGILVFV 206
MFS_PTR2 cd17350
Peptide transporter PTR2 of the Major Facilitator Superfamily of transporters; Fungal peptide ...
20-477 6.81e-12

Peptide transporter PTR2 of the Major Facilitator Superfamily of transporters; Fungal peptide transporter or permease PTR2 is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. It is a 12-transmembrane domain (TMD) integral membrane protein that translocates di-/tripeptides. As with other POT family proteins, it displays characteristic substrate multispecificity. PTR2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340908 [Multi-domain]  Cd Length: 438  Bit Score: 67.49  E-value: 6.81e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  20 PKAFYLIFSIELWERFGYYGLQGIMAVYL----------VKQLGMSEADSITLFSSFSALVYGLvaIGGWLGDKVLGTKR 89
Cdd:cd17350   1 PWSAFLIAIVELCERFSYYGLTGPFQNYMqfgpddstpgALGLGEQGATGLSNFFTFWCYVTPV--IGAYVADQFLGRYN 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  90 VIMLGAIVLAIGYALVAWSG------HDAGI--VYMGMAAIAVGNGLFKANPSSLLSTCYEKNDP--------------- 146
Cdd:cd17350  79 TIVCGAVIYFVGILILTCTSipsvidAGAGLggFVVAIIIIGLGTGGIKSNVSPLIADQLPKIKPyvktlkngervivdp 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 147 --RLDGAFTMYYMSVNIGSfFSMIATPWLAAKYGWSVAFALSVVGLLITIVNFAFCQrwvKQYGSKPDfepinyrnlllt 224
Cdd:cd17350 159 vvTLSRIYMIFYWAINVGS-LSLLATTYLERTKGFWYAYLLPLCVFVIPLIILAFGK---KFYKIRPD------------ 222
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 225 iigvvaliaiaTWLLhnqEVARmalgvvAFGIVVIFgkeafamkgaarrkmivafilmLEAIIFFVLYSQMPTSLNFFAI 304
Cdd:cd17350 223 -----------LFID---ELKR------ALRACKVF----------------------LFYPIYWVCYGQMTSNFISQAG 260
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 305 RNVEHSIlglavEPEQYQALNPFWIIIGSPILAAIYNKMGDTLPMP----TKFAIGMVMCSGAFLILPLGAKFASDAGI- 379
Cdd:cd17350 261 QMQLHGV-----PNDLFQAFDSIALIIFIPILENIIYPLLRKYNIPfkpiTRITLGFMFASFSMIYAAVLQAKIYQAGPc 335
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 380 ------------VSVSWLVASYGLQSIGELMISGLGLAMVAQLVPQRLMGFIMGSWFLTTAGANLIGgyvagmMAVPDNV 447
Cdd:cd17350 336 yanptgtcspndIHVWIQIPAYVLIAFSEIFASITGLEYAYTKAPPSMKSFITALFLLTNAFGAALS------IAISPAA 409
                       490       500       510
                ....*....|....*....|....*....|
gi 16129592 448 TDPLMSLevygrVFLQIGVATAVIAVLMLL 477
Cdd:cd17350 410 VDPKLTW-----MFTGIAVAAFIAGIMFWL 434
MFS_NPF8 cd17418
NRT1/PTR family (NPF), subfamily 8 of the Major Facilitator Superfamily of transporters; The ...
21-199 3.12e-11

NRT1/PTR family (NPF), subfamily 8 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF8 contains the Arabidopsis dipeptide transporters AtNPF8.1 (PTR1), AtNPF8.2 (PTR5), and AtNPF8.3 (PTR2), as well as tonoplast-localized transporters AtNPF8.4 (PTR4) and AtNPF8.5 (PTR6). Oryza sativa NRT1 (now called OsNPF8.9) is a low-affinity nitrate transporter. NPF8 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340976 [Multi-domain]  Cd Length: 447  Bit Score: 65.18  E-value: 3.12e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  21 KAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLAI 100
Cdd:cd17418   2 KACPFILGNECCERLAYYGIATNLITYLTKELHQGNVSAANNVTNWSGTCYITPLIGAFIADAYWGRYWTIASFSAIYFI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 101 GYALVAWSGH--------------------DAGIVYMGMAAIAVGNGLFKANPSSLLSTCYEKNDP----RLDGAFTMYY 156
Cdd:cd17418  82 GMVLLTLSASvpglkpascigslcppatsvQYAVFFLGLYLIALGTGGIKPCVSSFGADQFDDTDPkekvRKSSFFNWFY 161
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 16129592 157 MSVNIGSFFSMIATPWLAAKYGWSVAFALSVVGLLITIVNFAF 199
Cdd:cd17418 162 FSINIGALISSSVLVWIQENVGWGWGFGIPTVFMGIAIVSFFF 204
MFS_SLC15A2 cd17411
Solute carrier family 15 member 2 of the Major Facilitator Superfamily of transporters; Solute ...
20-438 4.78e-11

Solute carrier family 15 member 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 2 (SLC15A2), also called peptide transporter 2 (PepT2), is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. SLC15A2, as well as SLC15A1, mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A2 is a high-affinity transporter and is abundantly expressed in the apical membrane of kidney proximal tubules and choroid plexus epithelial cells. It is the major transporter involved in the reclamation of peptide-bound amino acids and peptide-like drugs in the kidney, and is also called the renal isoform. In choroid plexus and the brain, it acts as an efflux transporter and plays a role in regulating peptide/neuropeptide homeostasis. SLC15A2/PepT2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340969 [Multi-domain]  Cd Length: 403  Bit Score: 64.46  E-value: 4.78e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  20 PKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLA 99
Cdd:cd17411   1 PLSIAFIVVNEFCERFSYYGMKAVLTLYFLSFLHWDENLSTAIYHAFSGLCYFTPVLGALIADSWLGKFKTIIYLSIVYV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 100 IGY------ALVAWSGHDAGIV--YMGMAAIAVGNGLFKANPSSLLSTCY-EKNDPRLDGAFTMYYMSVNIGSFFSMIAT 170
Cdd:cd17411  81 VGHviksvgAIPTVGDQQVHVVlsMIGLFLIALGTGGIKPCVAAFGGDQFeEEHARERSKFFSIFYLSINAGSLISTFVT 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 171 PWLAAKY----GWSVAFALSVVGLLItivnfafcqrwvkqygskpdfepinyrnllltiigVVALiaiatwllhnqevar 246
Cdd:cd17411 161 PILRGDVqcfgGDCYALAFGVPAALM-----------------------------------VVAL--------------- 190
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 247 malgvvafgIVVIFGKEAFAMKGAARRkmivAFILMLEAIIFFVLYSQMPTSLNFFAIRnVEHSILGLAVEPEQYQALNP 326
Cdd:cd17411 191 ---------VVFIAGSGMYKEVKMVTR----VLFLYIPLPMFWALFDQQGSRWTLQATR-MNDFGGGFVLQPDQMQTLNP 256
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 327 FWIIIGSPI----LAAIYNKMGDTLPMPTKFAIGMVMCSGAFLilplgakfASDAGIVSVSWLVASYGLQSIGELMISGL 402
Cdd:cd17411 257 LLILVFIPIfdlgIYPLVSKCKINFTSLRKMATGMILAALAFA--------VAAAVEIKIAWQLPQYVLLSAGEVMFSIT 328
                       410       420       430
                ....*....|....*....|....*....|....*.
gi 16129592 403 GLAMVAQLVPQRLMGFIMGSWFLTTAGANLIGGYVA 438
Cdd:cd17411 329 GLEFSYSQAPASMKSVLQAGWLLTVAFGNVIVLIVA 364
MFS_NPF1_2 cd17416
NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters; ...
30-202 2.55e-09

NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF1 includes Medicago truncatula LATD/NIP, now named MtNPF1.7, which is a high-affinity nitrate transporter and is involved in nodulation and root architecture. NPF2 members are well-established nitrate and glucosinolate transporters, including Arabidopsis nitrate influx and efflux transporters with varied tissue and developmental specificity. Examples are AtNPF2.7, which is expressed in the cortex of mature roots, and AtNPF2.9, which is expressed in root companion cells where it is involved in phloem loading. NPF1/2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340974 [Multi-domain]  Cd Length: 444  Bit Score: 59.20  E-value: 2.55e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  30 ELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLAIGYALVAW-- 107
Cdd:cd17416   8 ETGEKLASYGLLANLIVYLIEEYNMKSIAAANIINIWSGTTNFLPVVGAFLSDSYFGRFPTISVGSFASLLGMVLLTLta 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 108 --------------------SGHDAGIVYMGMAAIAVGNGlfKANPSSL------LSTCYEKNDPRLDGAFTMYYMSVNI 161
Cdd:cd17416  88 aipslrpppcetasslcqspSKLQLAVLYSALALLSIGAG--GIRPCSLafgadqFDKKTESGKRGLESFFNWYYFTFTV 165
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 16129592 162 GSFFSMIATPWLAAKYGWSVAFALSVVGLLITIVNFAFCQR 202
Cdd:cd17416 166 AQIISLTAIVYIQDNVSWKIGFGIPAALMLLSFILFLAGSR 206
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
35-304 5.29e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 54.89  E-value: 5.29e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  35 FGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSaLVYGLVAI-GGWLGDKVlGTKRVIMLGAIVLAIGYALVAWSgHDAG 113
Cdd:COG2223  18 FGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPV-LVGALLRIpLGFLVDRF-GPRRVLLIGLLLLGIGLLLLALA-VSYW 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 114 IVYMGMAAIAVGNGLFKANPSSLLSTCYEKNdpRLDGAFTMYYMSVNIGSFFSMIATPWLAAKYGWSVAFALSVVGLLIT 193
Cdd:COG2223  95 LLLLLGLLLGIGGGGSFAVGIALVSKWFPPD--RRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVV 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 194 IVNFAFCQRWVKQYGSKPDFEPI--------NYRNLLLTI---IGVVALIAIATWL---------LHNQEVARMALGVVA 253
Cdd:COG2223 173 AVLAWLFLRDPPAGAAAAAKASLrdqlealrDPRFWLLSLlyfGTFGSFIGFSSWLppylvdqfgLSAATAGLLAALFAL 252
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 16129592 254 FGIVVIFGKEAFAMKGAARRKMIVAFILMleaIIFFVLYSQMPTSLNFFAI 304
Cdd:COG2223 253 LGALGRPLGGWLSDRIGGRRVLLIVFALM---ALGLLLLALALGSLWLFLV 300
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
35-206 8.27e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 54.11  E-value: 8.27e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  35 FGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLAIGYALVAWSGHDAGI 114
Cdd:COG2271 194 FALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPAL 273
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 115 VYMGMAAIAVGNGLFKANPSSLLSTCYEKNdpRLDGAFTMYYMSVNIGSFFSMIATPWLAAKYGWSVAFALSVVGLLITI 194
Cdd:COG2271 274 AIALLFLAGFGLGGAFGLLWALAAELFPKK--ARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAA 351
                       170
                ....*....|..
gi 16129592 195 VNFAFCQRWVKQ 206
Cdd:COG2271 352 LLALLLLRETRK 363
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
42-197 2.69e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 52.56  E-value: 2.69e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  42 GIMAVYLVKQLGMSEADSITLFSSFSaLVYGLVAI-GGWLGDKVlGTKRVIMLGAIVLAIGYALVAWSgHDAGIVYMGMA 120
Cdd:COG2271  30 SVAAPPLQADLGLSAAQLGLLASAFF-LGYALGQIpAGLLADRF-GRRRVLAIGLLLWGLATLLFGFA-TSFWQLLLLRF 106
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16129592 121 AIAVGNGLFKANPSSLLSTCYEKNDPRLdgAFTMYYMSVNIGSFFSMIATPWLAAKYGWSVAF-ALSVVGLLITIVNF 197
Cdd:COG2271 107 LLGLGEAGFFPAALKLIAEWFPPKERGR--ALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFlILGLPGLLLALLRF 182
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
2-199 3.00e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 52.58  E-value: 3.00e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592   2 STANQKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLG 81
Cdd:cd17325 180 KRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLS 259
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  82 DKVlGTKRVIMLGAIVLAIGYALVAWSGhDAGIVYMGMAAIAVGNGLFKANPSSLLSTCYeknDPRLDG-AFTMYYMSVN 160
Cdd:cd17325 260 DRI-GRKPLILIGLLLSAVALLLLPLAT-SFWLLLLLLALLGLGLGLVFPATLALLADIV---PPEGRGtAMGLFNTAFS 334
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 16129592 161 IGSFFSMIATPWLAAKYGWSVAFALSVVGLLITIVNFAF 199
Cdd:cd17325 335 LGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
35-195 3.26e-07

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 52.58  E-value: 3.26e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  35 FGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVlGTKRVIMLGAIVLAIGYALVAWSGHDAGI 114
Cdd:COG2223 219 GSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRI-GGRRVLLIVFALMALGLLLLALALGSLWL 297
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 115 VYMGMAAIAVGNGLFKANPSSLLSTCYEKNdpRLDGAFTMYYMSVNIGSFFSMIATPWLAAKYG-WSVAFALSVVGLLIT 193
Cdd:COG2223 298 FLVLFLLLGLALGGGNGAVFALVPDIFPTK--NAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVA 375

                ..
gi 16129592 194 IV 195
Cdd:COG2223 376 LV 377
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
20-197 4.43e-07

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 51.78  E-value: 4.43e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  20 PKAFYLIFSIELWERFGYYGlqGIMAVYLVKQLGMSEADSITLFSSFSaLVYGLVA-IGGWLGDKVlGTKRVIMLGAIVL 98
Cdd:cd17370 199 PKAFWLYLLAVALFALGNFS--FAFLILRAQELGLSAALIPLLYALFN-LVYALAAyPAGRLSDRI-GRKKLLILGYLSL 274
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  99 AIGYALVAWsGHDAGIVYMGMAAIAVGNGLFKANPSSLLSTCYEKNdpRLDGAFTMYYMSVNIGSFFSMIATPWLAAKYG 178
Cdd:cd17370 275 ALAYLGFAL-GSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAE--LRGTAYGLFNTVVGIGWLLASLIAGYLWDLIS 351
                       170
                ....*....|....*....
gi 16129592 179 WSVAFALSVVGLLITIVNF 197
Cdd:cd17370 352 PSAAFLFSAVLALIALLLL 370
MFS_NPF7 cd17419
NRT1/PTR family (NPF), subfamily 7 of the Major Facilitator Superfamily of transporters; The ...
20-197 5.40e-07

NRT1/PTR family (NPF), subfamily 7 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF7 includes the nitrate transporters AtNPF7.2 and AtNPF7.3, as well as the dipeptide transporter OsNPF7.3. AtNPF7.3 is a bidirectional transporter involved in nitrate influx and efflux. NPF7 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340977 [Multi-domain]  Cd Length: 447  Bit Score: 51.99  E-value: 5.40e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  20 PKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLA 99
Cdd:cd17419   1 WKSAIFILVNQGLATLAYFGVGVNLVLYLTRVMHQSNASAANNVSNWTGTVYITPLIGAFLSDSYWGRYWTSTLFQAIFV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 100 IGYALVAWSGH----------------------DAGIVYMGMAAIAVGNGLFKANPSSLLSTCYEKNDPRLDGA----FT 153
Cdd:cd17419  81 IGLLLLTLSSAlpslrppqcgdgdlkcppasaaQTTFLYFSLYLIALGYGGYQPCIATLGADQFDDEDPIEKASksafFS 160
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 16129592 154 MYYMSVNIGSFFSMIATPWLAAKYGWSVAFALSVVGLLITIVNF 197
Cdd:cd17419 161 YFYQALNLGSLFSNTILVYFEDNGSWGLGFGISAGAAFIGLVLF 204
MFS_1 pfam07690
Major Facilitator Superfamily;
35-434 6.88e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 51.26  E-value: 6.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592    35 FGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKvLGTKRVIMLGAIVLAIGYALVAWSgHDAGI 114
Cdd:pfam07690  10 LGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDR-FGRRRVLLIGLLLFALGLLLLLFA-SSLWL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592   115 VYMGMAAIAVGNGLFKANPSSLLSTCYEKNdpRLDGAFTMYYMSVNIGSFFSMIATPWLAAKYGWSVAFAlsvvglliti 194
Cdd:pfam07690  88 LLVLRVLQGLGAGALFPAALALIADWFPPE--ERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFL---------- 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592   195 vnfafcqrwvkqygskpdfepinyrnllltIIGVVALIAIATWLLHNQEVARMALGVVAFGIVVIFGKEAFAMKGAARRK 274
Cdd:pfam07690 156 ------------------------------ILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWL 205
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592   275 MIVAFILMLEAIIFFVLYSQMPTSLNFFAIRNVEHSILGLAVepeqyqalnpfwIIIGSPILAAIYNKMGDTLPMPTKFA 354
Cdd:pfam07690 206 LLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLL------------GAIGRLLLGRLSDRLGRRRRLLLALL 273
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592   355 IGMVMCSGAFLIlplgakfasdAGIVSVSWLVASYGLQSIGELMISGLGLAMVAQLVPQRLMGFIMGSWFLTTAGANLIG 434
Cdd:pfam07690 274 LLILAALGLLLL----------SLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
24-441 2.93e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 49.53  E-value: 2.93e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  24 YLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKvLGTKRVIMLGAIVLAIGYA 103
Cdd:cd17329   2 WVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADR-FGRKPVMLAGLLLRALGFA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 104 LVAWSgHDAGIVYMGMAAIAVGNGLFKANPSSLLSTCYEknDPRLDGAFTMYYMSVNIGSFFSMIATPWLAaKYGWSVAF 183
Cdd:cd17329  81 LLGFA-HSPWLFAIALVLTGFGGGLFEPASEAMIADVTT--PENRTRAFSLLYWAINLGVAIGPLLGGLLL-LYSFRLLF 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 184 alsvvgllitivnfafcqrwvkqygskpdfepinyrnLLLTIIGVVALIAIATWLLHNQEVARMALGVVAFGivvifgke 263
Cdd:cd17329 157 -------------------------------------LAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILR-------- 191
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 264 afAMKGAARRKMIVAFILMLeaIIFFVLYSQMPTSLNFFAIRNVEHSILGLAVepeqYQALNPFWIIIGSPILAAIYNKM 343
Cdd:cd17329 192 --GYKIVLRDRAFLLFLLAS--FLISLIYFQLESTLPVYVVEILGLGESLLGL----LLALNALLIVLLQFPVARLVERF 263
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 344 GDTLPMptkfAIGMVMCSGAFLILPLGAKFAsdagivsvsWLVASYGLQSIGELMISGLGLAMVAQLVPQRLMGFIMGSW 423
Cdd:cd17329 264 RLRKIL----MIGILLFAIGFAVLAFANTLA---------VLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFY 330
                       410
                ....*....|....*...
gi 16129592 424 FLTTAGANLIGGYVAGMM 441
Cdd:cd17329 331 ALAWGLGRAIGPLVGGLL 348
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
38-443 8.28e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 47.81  E-value: 8.28e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  38 YGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVlGTKRVIMLGAIVLAIGYALVAWSgHDAGIVYM 117
Cdd:cd06174  12 RGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRF-GRRPVLLLGLLLFALGALLFAFA-PSFWLLLL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 118 GMAAIAVGNGLFKANPSSLLSTCYEKndPRLDGAFTMYYMSVNIGSFFSMIATPWLAAKYGWSVAFALSVVGllitivnf 197
Cdd:cd06174  90 GRFLLGLGSGLIDPAVLALIADLFPE--RERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAA-------- 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 198 afcqrwvkqygskpdfepinyrnllltIIGVVALIAIATWLLHNQEVARMALGVVAFGIVVIFGKEAFAMKGAarrkmiv 277
Cdd:cd06174 160 ---------------------------ALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGL------- 205
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 278 aFILMLEAIIFFVLYSQMPTSLNFFAIRNVEHSILGLAVepeqYQALNPFWIIIGSPILAAIYNKMGDTLPMptkFAIGM 357
Cdd:cd06174 206 -WLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGL----LLSLFGLAGALGSLLLGLLSDRLIGRKPL---LLIGL 277
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 358 VMCSGAFLILPLGAkfasdagivSVSWLVASYGLQSIGELMISGLGLAMVAQLVPQRLMGFIMGSWFLTTAGANLIGGYV 437
Cdd:cd06174 278 LLMALGLALLLLAP---------SLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLL 348

                ....*.
gi 16129592 438 AGMMAV 443
Cdd:cd06174 349 AGFLLA 354
MFS_NPF3 cd17415
NRT1/PTR family (NPF), subfamily 3 of the Major Facilitator Superfamily of transporters; The ...
26-224 9.53e-06

NRT1/PTR family (NPF), subfamily 3 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF3 is the smallest NPF subfamily and it includes Cucumis sativus nitrite transporter (CsNitr1), now named CsNPF3.2. It functions as a chloroplast nitrite uptake transporter to remove toxic nitrite from the cytosol. NPF3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340973 [Multi-domain]  Cd Length: 448  Bit Score: 47.83  E-value: 9.53e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  26 IFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLAIGYALV 105
Cdd:cd17415   7 IFGNEICERLASVGFHTNLITYLTLQLHMPLVKAANILTNFNGTASLTPLLGAFIADSFAGRFWTITIGSIIYQLGMVLL 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 106 AWS------------GHDA----------GIVYMGMAAIAVGNGLFKANPSSLLSTCYEKNDPRLDGA----FTMYYMSV 159
Cdd:cd17415  87 TISailpslrpppcnGHEVcacqassaqlSILYLSLLLTALGSGGIRPCVVAFGADQFDESDPKQAKQtwnfFNWYYFCM 166
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16129592 160 NIGSFFSMIATPWLAAKYGWSVAFALSVVGLLITIVNFAFCQRWVKQYGSKPDFEPINYRNLLLT 224
Cdd:cd17415 167 GIAILLAVTVIVYIQDNVGWGWGFGIPTIAMAISVIAFVVGSPLYRELKSIIRMLPIWAAGILLV 231
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
3-178 2.60e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 46.43  E-value: 2.60e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592   3 TANQKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGD 82
Cdd:COG2211 210 PEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAK 289
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  83 KvLGTKRVIMLGAIVLAIGYALVAWSG-HDAGIVYMGMAAIAVGNGLFKANPSSLLSTC----YEKNDPRLDGAFT-MYY 156
Cdd:COG2211 290 R-FGKKKAFIIGLLLAALGLLLLFFLGpGNLWLLLVLAALAGIGLGAILVLPWAMLADVvdydEWKTGRRREGLYFgIFT 368
                       170       180
                ....*....|....*....|..
gi 16129592 157 MSVNIGSFFSMIATPWLAAKYG 178
Cdd:COG2211 369 FAIKLGQALAGALAGLLLALFG 390
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
51-195 3.93e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 46.02  E-value: 3.93e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  51 QLGMSEAdSITLFSSFSALVYGLVAI-GGWLGDKvLGTKRVIMLGAIVLAIGYALVAWSGhDAGIVYMGMAAIAVGNGLF 129
Cdd:COG2807  47 DLGLSAT-QAGLLTTLPLLAFGLFAPlAPRLARR-FGLERTLLLALLLLAAGLLLRSLAP-SVALLLAGTALIGAGIAVG 123
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16129592 130 KANPSSLLSTCYEKndpRLDGAFTMYYMSVNIGSFFSMIATPWLAAKYGWSVAFALSVVGLLITIV 195
Cdd:COG2807 124 NVLLPGLIKRWFPD---RVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALL 186
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
39-431 7.16e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 44.96  E-value: 7.16e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  39 GLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKvLGTKRVIMLGAIVLAIGYALVAWSgHDAGIVYMG 118
Cdd:COG2814  27 GIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADR-FGRRRVLLLGLLLFALGSLLCALA-PSLWLLLAA 104
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 119 MAAIAVGNGLFKANPSSLLSTCYEKNdpRLDGAFTMYYMSVNIGSFFSMIATPWLAAKYGWSVAFalsvvgllitivnfa 198
Cdd:COG2814 105 RFLQGLGAGALFPAALALIADLVPPE--RRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVF--------------- 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 199 fcqrwvkqygskpdfepinyrnLLLTIIGVVALIAIATWLLHNQEVARmalgvvafgivvifGKEAFAMKGAARRKMIVA 278
Cdd:COG2814 168 ----------------------LVNAVLALLALLLLLRLLPESRPAAR--------------ARLRGSLRELLRRPRLLL 211
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 279 FILMleAIIFFVLYSQMPTSLNFFAIRNVEHSILGLAVepeqYQALNPFWIIIGSPILAAIYNKMGdtlpMPTKFAIGMV 358
Cdd:COG2814 212 LLLL--AFLLGFGFFALFTYLPLYLQEVLGLSASAAGL----LLALFGLGGVLGALLAGRLADRFG----RRRLLLIGLL 281
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16129592 359 MCSGAFLILPLGAkfasdagivSVSWLVASYGLQSIGELMISGLGLAMVAQLVPQRLMGFIMGSWFLTTAGAN 431
Cdd:COG2814 282 LLALGLLLLALAG---------SLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
42-291 1.95e-04

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 43.26  E-value: 1.95e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  42 GIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKvLGTKRVIMLGAIVLAIGYALVAWSgHDAGIVYMGMAA 121
Cdd:COG0477  34 NVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDR-YGRKRVLLIGLLLFGLASLLCGLA-PSPELLIAARAL 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 122 IAVGNGLFKANPSSLLSTCYEKNDPRLdgAFTMYYMSVNIGSFFSMIATPWLAAKYGWSVAFALSVVGLLITIVNFAFCQ 201
Cdd:COG0477 112 QGIGAGGLMPGALALIAELFPARERGR--ALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLP 189
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 202 RWVKQYGSKPDFEPINYRNLLLTIIGVVALIAIATWLLHNQEVARMALGVVAFGIVVIFGKEAFAMKGAARRKMIVAFIL 281
Cdd:COG0477 190 ESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLL 269
                       250
                ....*....|
gi 16129592 282 MLEAIIFFVL 291
Cdd:COG0477 270 LLLALLLALL 279
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
4-195 2.30e-04

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 43.67  E-value: 2.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592   4 ANQKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDK 83
Cdd:cd17369 211 AGQVVRAPLVEVLRRHWRALLLAIGLRLAENVLFYLFTTFALSYATQTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDR 290
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  84 VlGTKRVIMLGAI---VLAIGYALVAWSGHDAGIVYMGMAAIAVGNGLFKANPSSLLSTCYEKNDpRLDGAFTMYYMSVN 160
Cdd:cd17369 291 V-GRRPVYLAGALlaaLFAFPFFWLLDTGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRV-RYTGASLGYQLGAI 368
                       170       180       190
                ....*....|....*....|....*....|....*.
gi 16129592 161 IGSFFS-MIATPWLAAKYGWSVAFALSVVGLLITIV 195
Cdd:cd17369 369 LGGGFApLIATALVAATGSWWPVALYLAALAVISLV 404
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
2-163 3.65e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 42.65  E-value: 3.65e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592   2 STANQKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLG 81
Cdd:COG2814 188 SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLA 267
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  82 DKvLGTKRVIMLGAIVLAIGYALVAWSGHdAGIVYMGMAAIAVGNGLFKANPSSLLSTCYEKNdpRLDGAFTMYYMSVNI 161
Cdd:COG2814 268 DR-FGRRRLLLIGLLLLALGLLLLALAGS-LWLLLLALFLLGFGFGLLFPLLQALVAELAPPE--ARGRASGLYNSAFFL 343

                ..
gi 16129592 162 GS 163
Cdd:COG2814 344 GG 345
MFS_SLC15A3_4 cd17348
Solute Carrier family 15 members 3 and 4 of the Major Facilitator Superfamily of transporters; ...
29-444 6.44e-04

Solute Carrier family 15 members 3 and 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 members 3 (SLC15A3) and 4 (SLC15A4) are members of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. They are peptide/histidine transporters (PHTs) that transport free histidine in addition to di/tripeptides. SLC15A4, also called peptide transporter 4 or peptide/histidine transporter 1 (PHT1), is expressed in the human brain, retina, placenta, and immune cells. It is required for Toll-like receptor 7 (TLR7)- and TLR9-mediated type I interferon production in plasmacytoid dendritic cells (pDCs) and is involved in the pathogenesis of lupus-like autoimmunity. SLC15A3, also called osteoclast transporter, peptide transporter 3, or peptide/histidine transporter 2 (PHT2), is expressed in immune tissues including the spleen and thymus. The SLC15A3/SLC15A4 group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340906 [Multi-domain]  Cd Length: 435  Bit Score: 42.08  E-value: 6.44e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  29 IELWERFGYYGLQGIMAVYLVKQ---LGMSEADSITLFssFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLAIGYALV 105
Cdd:cd17348  10 VELLERAAFYGITSNLVLFLNGSpfnWEGTQASQALLL--FMGATYLLSPFGGWLADAYLGRFWTILLSLLLYLLGMLLF 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 106 AWSGhdAGIVYMGMAAIAVGNGLFKANPSSLLSTCYEKNDPRLDGA-FTMYYMSVNIGSFFSMIATPWLAAKYGWSVAFA 184
Cdd:cd17348  88 PATA--APALYAGLLLVGLGVGSVKANITPFGADQVKDRGPEATRRfFNWFYWSINLGAILSLGGVAYIQQNVSFLIGYS 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 185 LSVVGLLITIVNFAFcqrwvkqygSKPDFepINYRNLLLTIIGVVALIAIatWLLHNQEVARMALGVVAFGIVVIFGKEA 264
Cdd:cd17348 166 IPAVCVGLAFLVFLC---------GQPVF--IDVKALVKILPVFLALIPY--WTVYFQMQTTYVLQSLHLKIPNIFISNI 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 265 FAMKGAARRkMIVAFILMLEAIIFFVLYSQMPTSLNFFAIRNvehsilGLAVEPEQYQALNPFWIIIgSPILAAI----- 339
Cdd:cd17348 233 AGITNSSHT-FPAAWLTMFDAVLILILIPLKDKLVDPFLKRR------GLLPSSLKRIAVGMFFVMC-SAIAAGIleskr 304
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 340 --YNKMGDTLPMptkfAIGMVMCSGAFLilplgakfasdagivSVSWLVASYGLQSIGELMISGLGLAMVAQLVPQRLMG 417
Cdd:cd17348 305 leIVKHNTTIQQ----QIGNVTYYAADL---------------PIWWQIPQYLLIGISEIFASIAGLEFAYSAAPKSMQS 365
                       410       420
                ....*....|....*....|....*..
gi 16129592 418 FIMGSWFLTTAGANLIGGYVAGMMAVP 444
Cdd:cd17348 366 AIMGLFFFFSGVGSFVGSGLLALVSIK 392
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
35-195 9.15e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 41.43  E-value: 9.15e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  35 FGYYGLQGIMAVYLVKQLGMSEADS--ITLFSSFSALVYGLvaIGGWLGDKVlGTKRVIMLGAIVLAIGYALVAWSGHDA 112
Cdd:cd17316 191 FGYYGLTTFLPTYLQTVLGLSPATSslYLLLISLGALVGAL--IAGLLSDRI-GRKKTLVIGLILSGILALPLFYLLSGS 267
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 113 GIVYMGMAAIAVGNGLFKANPSSLLSTCYEKNDPRLDGAFTMYYMSVNIGSFFSMIATPWLAAKYGWSVAFALSVVGLLI 192
Cdd:cd17316 268 PTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIV 347

                ...
gi 16129592 193 TIV 195
Cdd:cd17316 348 ALI 350
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
42-199 4.66e-03

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 39.09  E-value: 4.66e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  42 GIMAVYLVKQLGMSEADSITLFSSFSaLVYGLVAI-GGWLGDKVlGTKRVIMLGAIVLAIGYALVAWSGHdagivYMGMA 120
Cdd:cd17319  23 SVAAPTIMKDLGLSPTQYGLIASAFF-LGYALFQVpGGWLLDRF-GARKVLAVSMLLWSLFTALTGFATS-----LTSLY 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592 121 AIAVGNGLFKA--NPSSLLSTCYEKNDPRLDGAFTMYYMSVNIGSFFSMIATPWLAAKYGWSVAF-ALSVVGLLITIVNF 197
Cdd:cd17319  96 VLRFLLGVAEAgfFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFiIEGLLGLLLAVLWW 175

                ..
gi 16129592 198 AF 199
Cdd:cd17319 176 FY 177
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
1-199 7.93e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 38.71  E-value: 7.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592   1 MSTANQKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQgIMAVYLVKQLGMSEADSITLFSSFSALVyglVAIGGWL 80
Cdd:cd17473 177 ARKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIP-IQLPFLLQERGGGSAALIGLALAIASLA---GAIGALL 252
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  81 GDKV---LGTKRVIMLGAIVLAIGYALVAWSgHDAGIVYMGMAAIAVGNGLFKANPSSLLStcyEKNDPRLDGAFTMYY- 156
Cdd:cd17473 253 FGRLkrrLGKRRLLAIGFALMALGFLLLALA-SGLWVVLLGAILAGLGFGLLLPTLNSWAM---SLVPPELRGRAMGIVt 328
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 16129592 157 MSVNIGSFFS-MIATPWLAAKYGWSVAFALS-VVGLLITIVNFAF 199
Cdd:cd17473 329 SAFFLGQFLSpLVLGPLVNLTGGLSGAFLILgVLALVLAIVLLLL 373
MFS_BCD_PucC-like cd06176
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ...
52-129 8.68e-03

Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 349950 [Multi-domain]  Cd Length: 409  Bit Score: 38.64  E-value: 8.68e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129592  52 LGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLAIGYALVAWSG--HDAGIVYMGMAAIAVGNGLF 129
Cdd:cd06176 254 FGMSVGETTRLTAIWGGGTLLGMLLAGFLLSRRLGKKRTAALGCLLSALGFLLLALAGllGNPWLFRPGVFLLGLGNGLF 333
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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