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Conserved domains on  [gi|16129795|ref|NP_416356|]
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DNA polymerase III subunit theta [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

DNA polymerase III subunit theta( domain architecture ID 10013689)

DNA polymerase III subunit theta is part of the DNA polymerase III core complex, a multichain enzyme responsible for most of the replicative synthesis in bacteria; also exhibits 3' to 5' exonuclease activity

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10969 PRK10969
DNA polymerase III subunit theta; Reviewed
 1-74 2.24e-48

DNA polymerase III subunit theta; Reviewed


:

Pssm-ID: 182872  Cd Length: 75  Bit Score: 147.21  E-value: 2.24e-48
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16129795   1 MLKNLAKLDQTEMDKVNVDLAAAGVAFKERYNMPVIAEAVEREQPEHLRSWFRERLIAHRLASVNLSRLPYEPK 74
Cdd:PRK10969  1 MGKNLAKLSQEEMDKVNVDLAASGVAFKERYNMPVIAEAVEREQPEHLRSYFRERLIAYRLASVNLSRLPYEPK 74
 
Name Accession Description Interval E-value
PRK10969 PRK10969
DNA polymerase III subunit theta; Reviewed
 1-74 2.24e-48

DNA polymerase III subunit theta; Reviewed


Pssm-ID: 182872  Cd Length: 75  Bit Score: 147.21  E-value: 2.24e-48
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16129795   1 MLKNLAKLDQTEMDKVNVDLAAAGVAFKERYNMPVIAEAVEREQPEHLRSWFRERLIAHRLASVNLSRLPYEPK 74
Cdd:PRK10969  1 MGKNLAKLSQEEMDKVNVDLAASGVAFKERYNMPVIAEAVEREQPEHLRSYFRERLIAYRLASVNLSRLPYEPK 74
DNA_pol3_theta pfam06440
DNA polymerase III, theta subunit; DNA polymerase III (EC 2.7.7.7) is comprised of three ...
 4-71 8.90e-39

DNA polymerase III, theta subunit; DNA polymerase III (EC 2.7.7.7) is comprised of three tightly associated subunits, alpha, epsilon and theta. This family contains the theta subunit. The structure of the theta subunit shows that the N-terminal two thirds is comprised of three helices while the C-terminal third is disordered. The function of the theta subunit is poorly understood, but the interaction of the theta subunit with the epsilon subunit is thought to enhance the 3' to 5' exonucleolytic proofreading activity of epsilon.


Pssm-ID: 428944  Cd Length: 70  Bit Score: 122.92  E-value: 8.90e-39
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16129795    4 NLAKLDQTEMDKVNVDLAAAGVAFKERYNMPVIAEAVEREQPEHLRSWFRERLIAHRLASVNLSRLPY 71
Cdd:pfam06440  3 NLAELSKEEMDKVNVDLAASGVAFKERYNMPVVAEQVEREQPEHLREYFRERLIYYRLESKQLSRLPY 70
 
Name Accession Description Interval E-value
PRK10969 PRK10969
DNA polymerase III subunit theta; Reviewed
 1-74 2.24e-48

DNA polymerase III subunit theta; Reviewed


Pssm-ID: 182872  Cd Length: 75  Bit Score: 147.21  E-value: 2.24e-48
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16129795   1 MLKNLAKLDQTEMDKVNVDLAAAGVAFKERYNMPVIAEAVEREQPEHLRSWFRERLIAHRLASVNLSRLPYEPK 74
Cdd:PRK10969  1 MGKNLAKLSQEEMDKVNVDLAASGVAFKERYNMPVIAEAVEREQPEHLRSYFRERLIAYRLASVNLSRLPYEPK 74
DNA_pol3_theta pfam06440
DNA polymerase III, theta subunit; DNA polymerase III (EC 2.7.7.7) is comprised of three ...
 4-71 8.90e-39

DNA polymerase III, theta subunit; DNA polymerase III (EC 2.7.7.7) is comprised of three tightly associated subunits, alpha, epsilon and theta. This family contains the theta subunit. The structure of the theta subunit shows that the N-terminal two thirds is comprised of three helices while the C-terminal third is disordered. The function of the theta subunit is poorly understood, but the interaction of the theta subunit with the epsilon subunit is thought to enhance the 3' to 5' exonucleolytic proofreading activity of epsilon.


Pssm-ID: 428944  Cd Length: 70  Bit Score: 122.92  E-value: 8.90e-39
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16129795    4 NLAKLDQTEMDKVNVDLAAAGVAFKERYNMPVIAEAVEREQPEHLRSWFRERLIAHRLASVNLSRLPY 71
Cdd:pfam06440  3 NLAELSKEEMDKVNVDLAASGVAFKERYNMPVVAEQVEREQPEHLREYFRERLIYYRLESKQLSRLPY 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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