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Conserved domains on  [gi|16129879|ref|NP_416442|]
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putative acetyltransferase YedL [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10003213)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 42-152 1.20e-21

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


:

Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 84.66  E-value: 1.20e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129879  42 LRNPTVTFWSVWEGEQLAGIGALKLLDDKHGELKSMRTAPNYLRRGVASLILRHILQVAQDRCLHRLSLETGTQAgftac 121
Cdd:COG1246  23 LEEEIGEFWVAEEDGEIVGCAALHPLDEDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLTTSAA----- 97

                        90       100       110
                ....*....|....*....|....*....|....
gi 16129879 122 HQLYLKHGFADCEPF---ADYRLDPHSRFLSLTL 152
Cdd:COG1246  98 IHFYEKLGFEEIDKEdlpYAKVWQRDSVVMEKDL 131
 
Name Accession Description Interval E-value
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 42-152 1.20e-21

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 84.66  E-value: 1.20e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129879  42 LRNPTVTFWSVWEGEQLAGIGALKLLDDKHGELKSMRTAPNYLRRGVASLILRHILQVAQDRCLHRLSLETGTQAgftac 121
Cdd:COG1246  23 LEEEIGEFWVAEEDGEIVGCAALHPLDEDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLTTSAA----- 97

                        90       100       110
                ....*....|....*....|....*....|....
gi 16129879 122 HQLYLKHGFADCEPF---ADYRLDPHSRFLSLTL 152
Cdd:COG1246  98 IHFYEKLGFEEIDKEdlpYAKVWQRDSVVMEKDL 131
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 31-130 3.01e-13

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 62.54  E-value: 3.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129879    31 PESSHALDVQKLRNPTVTFWSVWEGEQLAGIGALKLLDD--KHGELKSMRTAPNYLRRGVASLILRHILQVAQDRCLHRL 108
Cdd:pfam00583  17 PDEPLDLLEDWDEDASEGFFVAEEDGELVGFASLSIIDDepPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERI 96

                          90       100
                  ....*....|....*....|..
gi 16129879   109 SLEtgTQAGFTACHQLYLKHGF 130
Cdd:pfam00583  97 FLE--VAADNLAAIALYEKLGF 116
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 49-111 4.81e-07

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 44.57  E-value: 4.81e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16129879  49 FWSVWEGEQLAGIGALKLLD--DKHGELKSMRTAPNYLRRGVASLILRHILQVAQDRCLHRLSLE 111
Cdd:cd04301   1 FLVAEDDGEIVGFASLSPDGsgGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
PRK07757 PRK07757
N-acetyltransferase;
12-102 2.61e-04

N-acetyltransferase;


Pssm-ID: 236088 [Multi-domain]  Cd Length: 152  Bit Score: 39.02  E-value: 2.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129879   12 PAVQALVAYHISG--MLqqsppESSHALDVQKLRNptvtFWSVWEGEQLAGIGALKLLDDKHGELKSMRTAPNYLRRGVA 89
Cdd:PRK07757  13 KAIHALINVYAKKglML-----PRSLDELYENIRD----FYVAEEEGEIVGCCALHILWEDLAEIRSLAVSEDYRGQGIG 83

                         90
                 ....*....|...
gi 16129879   90 SLILRHILQVAQD 102
Cdd:PRK07757  84 RMLVEACLEEARE 96
 
Name Accession Description Interval E-value
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 42-152 1.20e-21

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 84.66  E-value: 1.20e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129879  42 LRNPTVTFWSVWEGEQLAGIGALKLLDDKHGELKSMRTAPNYLRRGVASLILRHILQVAQDRCLHRLSLETGTQAgftac 121
Cdd:COG1246  23 LEEEIGEFWVAEEDGEIVGCAALHPLDEDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLKRLFLLTTSAA----- 97

                        90       100       110
                ....*....|....*....|....*....|....
gi 16129879 122 HQLYLKHGFADCEPF---ADYRLDPHSRFLSLTL 152
Cdd:COG1246  98 IHFYEKLGFEEIDKEdlpYAKVWQRDSVVMEKDL 131
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 37-143 2.96e-13

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 62.76  E-value: 2.96e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129879  37 LDVQKLRNPTVTFWS---------VWEGEQLAGIGALKLLDDKHGELKSMRTAPNYLRRGVASLILRHILQVAQDRCLHR 107
Cdd:COG0454  15 LLIEALDAELKAMEGslagaefiaVDDKGEPIGFAGLRRLDDKVLELKRLYVLPEYRGKGIGKALLEALLEWARERGCTA 94

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 16129879 108 LSLETGTQAGFTacHQLYLKHGFADCEPFADYRLDP 143
Cdd:COG0454  95 LELDTLDGNPAA--IRFYERLGFKEIERYVAYVGGE 128
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 31-130 3.01e-13

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 62.54  E-value: 3.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129879    31 PESSHALDVQKLRNPTVTFWSVWEGEQLAGIGALKLLDD--KHGELKSMRTAPNYLRRGVASLILRHILQVAQDRCLHRL 108
Cdd:pfam00583  17 PDEPLDLLEDWDEDASEGFFVAEEDGELVGFASLSIIDDepPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERI 96

                          90       100
                  ....*....|....*....|..
gi 16129879   109 SLEtgTQAGFTACHQLYLKHGF 130
Cdd:pfam00583  97 FLE--VAADNLAAIALYEKLGF 116
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
57-143 1.16e-09

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 52.22  E-value: 1.16e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129879  57 QLAGIGALKLLDDKHGELKSMRTAPNYLRRGVASLILRHILQVAQDRCLHRLSLETGTqAGFTAcHQLYLKHGFADCEPF 136
Cdd:COG3393   1 ELVAMAGVRAESPGVAEISGVYTHPEYRGRGLASALVAALAREALARGARTPFLYVDA-DNPAA-RRLYERLGFRPVGEY 78


                ....*..
gi 16129879 137 ADYRLDP 143
Cdd:COG3393  79 ATVLFRK 85
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 48-130 2.43e-09

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 51.30  E-value: 2.43e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129879    48 TFWSVWEGEQLAG-IGALKLLDDKHGELKSMRTAPNYLRRGVASLILRHILQVAQDRCLHRLSLETGTQAgftacHQLYL 126
Cdd:pfam13508   4 RFFVAEDDGKIVGfAALLPLDDEGALAELRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETTNRA-----AAFYE 78


                  ....
gi 16129879   127 KHGF 130
Cdd:pfam13508  79 KLGF 82
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 61-143 3.14e-09

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 51.19  E-value: 3.14e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129879  61 IGALKLLDDKHGELKSMRTAPNYLRRGVASLILRHILQVAQDRCLHRLSLETGTQAgfTACHQLYLKHGFADCEPFADYR 140
Cdd:COG0456   3 ALLGLVDGGDEAEIEDLAVDPEYRGRGIGRALLEAALERARERGARRLRLEVREDN--EAAIALYEKLGFEEVGERPNYY 80


                ...
gi 16129879 141 LDP 143
Cdd:COG0456  81 GDD 83
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
22-152 8.60e-08

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 48.54  E-value: 8.60e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129879  22 ISGMLQQSPPESSHALDVQKLRN--PTVTFWSVWEGEQLAGIGALKLL----DDKHGELKSMRTAPNYLRRGVASLILRH 95
Cdd:COG3153  12 IAALLRAAFGPGREAELVDRLREdpAAGLSLVAEDDGEIVGHVALSPVdidgEGPALLLGPLAVDPEYRGQGIGRALMRA 91

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 16129879  96 ILQVAQDRCLHRLSLETGTQAgftacHQLYLKHGFADCEPFaDYRLDPHSRFLSLTL 152
Cdd:COG3153  92 ALEAARERGARAVVLLGDPSL-----LPFYERFGFRPAGEL-GLTLGPDEVFLAKEL 142
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 49-111 4.81e-07

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 44.57  E-value: 4.81e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16129879  49 FWSVWEGEQLAGIGALKLLD--DKHGELKSMRTAPNYLRRGVASLILRHILQVAQDRCLHRLSLE 111
Cdd:cd04301   1 FLVAEDDGEIVGFASLSPDGsgGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGAKRLRLE 65
PRK07757 PRK07757
N-acetyltransferase;
12-102 2.61e-04

N-acetyltransferase;


Pssm-ID: 236088 [Multi-domain]  Cd Length: 152  Bit Score: 39.02  E-value: 2.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129879   12 PAVQALVAYHISG--MLqqsppESSHALDVQKLRNptvtFWSVWEGEQLAGIGALKLLDDKHGELKSMRTAPNYLRRGVA 89
Cdd:PRK07757  13 KAIHALINVYAKKglML-----PRSLDELYENIRD----FYVAEEEGEIVGCCALHILWEDLAEIRSLAVSEDYRGQGIG 83

                         90
                 ....*....|...
gi 16129879   90 SLILRHILQVAQD 102
Cdd:PRK07757  84 RMLVEACLEEARE 96
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
1-130 4.27e-04

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 38.44  E-value: 4.27e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129879   1 MFTI---KTDDLthPAVQALVAYHISGMLQ----QSPPESSHALDVQKLRNPTVTFWSVWEGEQLAGIGALKLL-----D 68
Cdd:COG1247   1 EMTIrpaTPEDA--PAIAAIYNEAIAEGTAtfetEPPSEEEREAWFAAILAPGRPVLVAEEDGEVVGFASLGPFrprpaY 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16129879  69 DKHGELkSMRTAPNYLRRGVASLILRHILQVAQDRCLHRLSLETGtqAGFTACHQLYLKHGF 130
Cdd:COG1247  79 RGTAEE-SIYVDPDARGRGIGRALLEALIERARARGYRRLVAVVL--ADNEASIALYEKLGF 137
COG3981 COG3981
Predicted acetyltransferase [General function prediction only];
45-108 9.06e-04

Predicted acetyltransferase [General function prediction only];


Pssm-ID: 443180  Cd Length: 170  Bit Score: 37.58  E-value: 9.06e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16129879  45 PTVTFWSVWEGEQLAGIGALKL-LDDK------H-GelksMRTAPNYLRRGVASLILRHILQVAQDRCLHRL 108
Cdd:COG3981  61 PATTYWLVDEDGRIVGAINLRHeLNEFllrvggHiG----YGVRPSERGKGYATEMLRLALEEARELGLDRV 128
PRK07922 PRK07922
amino-acid N-acetyltransferase;
42-134 2.68e-03

amino-acid N-acetyltransferase;


Pssm-ID: 236132 [Multi-domain]  Cd Length: 169  Bit Score: 36.44  E-value: 2.68e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129879   42 LRNPTVT-------FW-SVWEGEQLAGIGALKLLDDKHGELKSMRTAPNYLRRGVASLILRHILQVAQDRCLHR---LSL 110
Cdd:PRK07922  33 LEKNLVTlyeavqeFWvAEHLDGEVVGCGALHVMWEDLAEIRTVAVDPAARGRGVGHAIVERLLDVARELGLSRvfvLTF 112

                         90       100
                 ....*....|....*....|....
gi 16129879  111 ETgtqaGFTAchqlylKHGFADCE 134
Cdd:PRK07922 113 EV----EFFA------RHGFVEID 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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