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Conserved domains on  [gi|16129972|ref|NP_416536|]
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putative glycosyltransferase WbbK [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

glycosyltransferase family 4 protein( domain architecture ID 10133545)

glycosyltransferase family 4 (GT4) protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds

CAZY:  GT4
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
PubMed:  12691742|10521532|16037492
SCOP:  3001586

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 5-367 1.58e-45

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


:

Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 159.84  E-value: 1.58e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972   5 IVVVSAVNFTTGGPFTILKKFLAA-TNNKENVSFIALVHSAKELKESYPWVKFIEFPEVKGSWLKRLHFEYVVCKKLSKE 83
Cdd:cd03809   3 LIDGRSLAQRLTGIGRYTRELLKAlAKNDPDESVLAVPPLPGELLRLLREYPELSLGVIKIKLWRELALLRWLQILLPKK 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972  84 LNATHWICLHDITANVVTKKRYV-YCHNPAPFYKgilfreilmePSFF--LFKMLYGLIYKINIKKNTAVFVQQFWMKEK 160
Cdd:cd03809  83 DKPDLLHSPHNTAPLLLKGCPQVvTIHDLIPLRY----------PEFFpkRFRLYYRLLLPISLRRADAIITVSEATRDD 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972 161 FIKKYSI--NNIIVSRPEIKLSDKSQLTDDDSQFKNNPSELTIFYPAVPRVFKNYELIISAARKLKEQSNIKFLLTI--S 236
Cdd:cd03809 153 IIKFYGVppEKIVVIPLGVDPSFFPPESAAVLIAKYLLPEPYFLYVGTLEPRKNHERLLKAFALLKKQGGDLKLVIVggK 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972 237 GTENAYAKYIISLAEGLDNVHFLGYLDKEKIDHCYNISDIVCFPSRLETWGLPLSEAKERGKWVLASDFPFTRETLGsyE 316
Cdd:cd03809 233 GWEDEELLDLVKKLGLGGRVRFLGYVSDEDLPALYRGARAFVFPSLYEGFGLPVLEAMACGTPVIASNISVLPEVAG--D 310

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|.
gi 16129972 317 KKAFFDSNNddmlvklIIDFKKGnLKKDISDANFIYRNENvlVGFDELVNF 367
Cdd:cd03809 311 AALYFDPLD-------PESIADA-ILRLLEDPSLREELIR--KGLERAKKF 351
 
Name Accession Description Interval E-value
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 5-367 1.58e-45

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 159.84  E-value: 1.58e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972   5 IVVVSAVNFTTGGPFTILKKFLAA-TNNKENVSFIALVHSAKELKESYPWVKFIEFPEVKGSWLKRLHFEYVVCKKLSKE 83
Cdd:cd03809   3 LIDGRSLAQRLTGIGRYTRELLKAlAKNDPDESVLAVPPLPGELLRLLREYPELSLGVIKIKLWRELALLRWLQILLPKK 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972  84 LNATHWICLHDITANVVTKKRYV-YCHNPAPFYKgilfreilmePSFF--LFKMLYGLIYKINIKKNTAVFVQQFWMKEK 160
Cdd:cd03809  83 DKPDLLHSPHNTAPLLLKGCPQVvTIHDLIPLRY----------PEFFpkRFRLYYRLLLPISLRRADAIITVSEATRDD 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972 161 FIKKYSI--NNIIVSRPEIKLSDKSQLTDDDSQFKNNPSELTIFYPAVPRVFKNYELIISAARKLKEQSNIKFLLTI--S 236
Cdd:cd03809 153 IIKFYGVppEKIVVIPLGVDPSFFPPESAAVLIAKYLLPEPYFLYVGTLEPRKNHERLLKAFALLKKQGGDLKLVIVggK 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972 237 GTENAYAKYIISLAEGLDNVHFLGYLDKEKIDHCYNISDIVCFPSRLETWGLPLSEAKERGKWVLASDFPFTRETLGsyE 316
Cdd:cd03809 233 GWEDEELLDLVKKLGLGGRVRFLGYVSDEDLPALYRGARAFVFPSLYEGFGLPVLEAMACGTPVIASNISVLPEVAG--D 310

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|.
gi 16129972 317 KKAFFDSNNddmlvklIIDFKKGnLKKDISDANFIYRNENvlVGFDELVNF 367
Cdd:cd03809 311 AALYFDPLD-------PESIADA-ILRLLEDPSLREELIR--KGLERAKKF 351
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 211-357 7.22e-30

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 112.37  E-value: 7.22e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972   211 KNYELIISAARKLKEQ-SNIKFLLTISGTENAYAKYIISLAEGLDNVHFLGYLDKEKIDHCYNISDIVCFPSRLETWGLP 289
Cdd:pfam00534  15 KGLDLLIKAFALLKEKnPNLKLVIAGDGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIADVFVLPSRYEGFGIV 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16129972   290 LSEAKERGKWVLASDFPFTRETLGSYEKKAFFDSNNDDMLVKLIIDFkkgnLKKDISDANFIYRNENV 357
Cdd:pfam00534  95 LLEAMACGLPVIASDVGGPPEVVKDGETGFLVKPNNAEALAEAIDKL----LEDEELRERLGENARKR 158
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 259-336 1.67e-07

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 49.60  E-value: 1.67e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972 259 LGYLDKEK-----IDHCYNISDIVCFPSRLETWGLPLSEAKERGKWVLASDFPFTRETLGSYEKKAFFDSNNDDMLVKLI 333
Cdd:COG0438   1 MGRLVPRKgldllLEALLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPPGDPEALAEAI 80


                ...
gi 16129972 334 IDF 336
Cdd:COG0438  81 LRL 83
MSMEG_0565_glyc TIGR04047
glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from ...
 256-310 6.94e-04

glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from Actinobacteria to Proteobacteria to Cyanobacteria features a radical SAM protein, an N-acetyltransferase, an oxidoreductase, and two additional proteins whose functional classes are unclear. The metabolic role of the cluster is probably biosynthetic. This glycosyltransferase, named from member MSMEG_0565 from Mycobacterium smegmatis, occurs in most but not all instances of the cluster. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274943 [Multi-domain]  Cd Length: 373  Bit Score: 41.23  E-value: 6.94e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 16129972   256 VHFLGYLDKEKIDHCYNISDIVCFPSRLETWGLPLSEAKERGKWVLASDF-PFTRE 310
Cdd:TIGR04047 259 VVITGPVPDADLPALYRCADAFAFPSLKEGFGLVVLEALASGIPVVASDIaPFTEY 314
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
182-303 1.27e-03

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 40.54  E-value: 1.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972  182 KSQLTDDDSQFKNNPSELT-IFYPAVPRVFKNYELIISAARKL-KEQSNIKFLL------TISGTENAYAKYIISLAEGL 253
Cdd:PRK15484 176 QSNPQPNLRQQLNISPDETvLLYAGRISPDKGILLLMQAFEKLaTAHSNLKLVVvgdptaSSKGEKAAYQKKVLEAAKRI 255

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 16129972  254 -DNVHFLGYLDKEKIDHCYNISDIVCFPSRL-ETWGLPLSEAKERGKWVLAS 303
Cdd:PRK15484 256 gDRCIMLGGQPPEKMHNYYPLADLVVVPSQVeEAFCMVAVEAMAAGKPVLAS 307
 
Name Accession Description Interval E-value
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 5-367 1.58e-45

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 159.84  E-value: 1.58e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972   5 IVVVSAVNFTTGGPFTILKKFLAA-TNNKENVSFIALVHSAKELKESYPWVKFIEFPEVKGSWLKRLHFEYVVCKKLSKE 83
Cdd:cd03809   3 LIDGRSLAQRLTGIGRYTRELLKAlAKNDPDESVLAVPPLPGELLRLLREYPELSLGVIKIKLWRELALLRWLQILLPKK 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972  84 LNATHWICLHDITANVVTKKRYV-YCHNPAPFYKgilfreilmePSFF--LFKMLYGLIYKINIKKNTAVFVQQFWMKEK 160
Cdd:cd03809  83 DKPDLLHSPHNTAPLLLKGCPQVvTIHDLIPLRY----------PEFFpkRFRLYYRLLLPISLRRADAIITVSEATRDD 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972 161 FIKKYSI--NNIIVSRPEIKLSDKSQLTDDDSQFKNNPSELTIFYPAVPRVFKNYELIISAARKLKEQSNIKFLLTI--S 236
Cdd:cd03809 153 IIKFYGVppEKIVVIPLGVDPSFFPPESAAVLIAKYLLPEPYFLYVGTLEPRKNHERLLKAFALLKKQGGDLKLVIVggK 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972 237 GTENAYAKYIISLAEGLDNVHFLGYLDKEKIDHCYNISDIVCFPSRLETWGLPLSEAKERGKWVLASDFPFTRETLGsyE 316
Cdd:cd03809 233 GWEDEELLDLVKKLGLGGRVRFLGYVSDEDLPALYRGARAFVFPSLYEGFGLPVLEAMACGTPVIASNISVLPEVAG--D 310

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|.
gi 16129972 317 KKAFFDSNNddmlvklIIDFKKGnLKKDISDANFIYRNENvlVGFDELVNF 367
Cdd:cd03809 311 AALYFDPLD-------PESIADA-ILRLLEDPSLREELIR--KGLERAKKF 351
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 211-357 7.22e-30

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 112.37  E-value: 7.22e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972   211 KNYELIISAARKLKEQ-SNIKFLLTISGTENAYAKYIISLAEGLDNVHFLGYLDKEKIDHCYNISDIVCFPSRLETWGLP 289
Cdd:pfam00534  15 KGLDLLIKAFALLKEKnPNLKLVIAGDGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIADVFVLPSRYEGFGIV 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16129972   290 LSEAKERGKWVLASDFPFTRETLGSYEKKAFFDSNNDDMLVKLIIDFkkgnLKKDISDANFIYRNENV 357
Cdd:pfam00534  95 LLEAMACGLPVIASDVGGPPEVVKDGETGFLVKPNNAEALAEAIDKL----LEDEELRERLGENARKR 158
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 52-304 5.80e-15

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 75.27  E-value: 5.80e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972  52 PWVKFIEFPEVKGSWLKRLHFEYVVCKKLSKELNATHWICLHDItanvvtkkryVYCHNPAPFYKGILFREILMEP---- 127
Cdd:cd03801  42 PGEPPEELEDGVIVPLLPSLAALLRARRLLRELRPLLRLRKFDV----------VHAHGLLAALLAALLALLLGAPlvvt 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972 128 --------SFFLFKMLYGLIYKINIKKNTA---VFVQQfWMKEKFIKKY--SINNIIVSRPEIKLSDKSqlTDDDSQFKN 194
Cdd:cd03801 112 lhgaepgrLLLLLAAERRLLARAEALLRRAdavIAVSE-ALRDELRALGgiPPEKIVVIPNGVDLERFS--PPLRRKLGI 188

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972 195 NPSELTIFYPAVPRVFKNYELIISAARKLKEQSNiKFLLTISGTENAYAKYIISLAEGL-DNVHFLGYLDKEKIDHCYNI 273
Cdd:cd03801 189 PPDRPVLLFVGRLSPRKGVDLLLEALAKLLRRGP-DVRLVIVGGDGPLRAELEELELGLgDRVRFLGFVPDEELPALYAA 267

                       250       260       270
                ....*....|....*....|....*....|.
gi 16129972 274 SDIVCFPSRLETWGLPLSEAKERGKWVLASD 304
Cdd:cd03801 268 ADVFVLPSRYEGFGLVVLEAMAAGLPVVATD 298
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 102-311 3.58e-13

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 69.93  E-value: 3.58e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972 102 KKRYVYCHNPAP-FYKGILFREILMEPSF-------FLF------KMLYGLIYKINIKKNTAVFVQQFWMKEKFIKKYSI 167
Cdd:cd03808  81 KPDIVHCHTPKPgILGRLAARLAGVPKVIytvhglgFVFtegkllRLLYLLLEKLALLFTDKVIFVNEDDRDLAIKKGII 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972 168 NniivsrpeiklSDKSQLTD----DDSQFKNNPSEL-----TIFYPAVPRVFKNYELIISAARKLKEQ-SNIKFLLTISG 237
Cdd:cd03808 161 K-----------KKKTVLIPgsgvDLDRFQYSPESLpsekvVFLFVARLLKDKGIDELIEAAKILKKKgPNVRFLLVGDG 229

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16129972 238 -TENAYAKYIISLAEGlDNVHFLGYLDKekIDHCYNISDIVCFPSRLEtwGLPLS--EAKERGKWVLASDFPFTRET 311
Cdd:cd03808 230 eLENPSEILIEKLGLE-GRIEFLGFRSD--VPELLAESDVFVLPSYRE--GLPRSllEAMAAGRPVITTDVPGCREL 301
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 211-312 2.25e-12

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 65.89  E-value: 2.25e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972 211 KNYELIISAARKLKEQ-SNIKFLLTISGTENAYAKYIISLAEGLDNVHFLG-YLDKEKIDHCYNISDIVCFPSRLETWGL 288
Cdd:cd01635 123 KGIDLLLEALALLKARlPDLVLVLVGGGGEREEEEALAAALGLLERVVIIGgLVDDEVLELLLAAADVFVLPSRSEGFGL 202

                        90       100
                ....*....|....*....|....
gi 16129972 289 PLSEAKERGKWVLASDFPFTRETL 312
Cdd:cd01635 203 VLLEAMAAGKPVIATDVGGIPEFV 226
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
211-312 3.75e-10

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 57.52  E-value: 3.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972   211 KNYELIISAARKLKEQSN-IKFLLTISGTEnayaKYIISLAEGL-DNVHFLGYLDKekIDHCYNISDIVCFPSRLETWGL 288
Cdd:pfam13692  15 KGVDYLLEAVPLLRKRDNdVRLVIVGDGPE----EELEELAAGLeDRVIFTGFVED--LAELLAAADVFVLPSLYEGFGL 88

                          90       100
                  ....*....|....*....|....
gi 16129972   289 PLSEAKERGKWVLASDFPFTRETL 312
Cdd:pfam13692  89 KLLEAMAAGLPVVATDVGGIPELV 112
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 210-305 1.04e-09

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 59.26  E-value: 1.04e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972 210 FKNYELIISAARKLKEQsNIKFLLTISGTENAYAKYiislaEGLDNVHFLGYLDKEKIDHCYNISDIVCFPSR-LETWGL 288
Cdd:cd03823 203 EKGIDLLVEAFKRLPRE-DIELVIAGHGPLSDERQI-----EGGRRIAFLGRVPTDDIKDFYEKIDVLVVPSIwPEPFGL 276

                        90
                ....*....|....*..
gi 16129972 289 PLSEAKERGKWVLASDF 305
Cdd:cd03823 277 VVREAIAAGLPVIASDL 293
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 211-293 4.56e-09

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 57.29  E-value: 4.56e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972 211 KNYELIISAARKLKEQSNIKFLLTISGTENAYAKYIISLAEGLDNVHFLGYLDKEKIDHCYNISDIVCFPSRLETWGLPL 290
Cdd:cd03817 214 KNIDFLLRAFAELKKEPNIKLVIVGDGPEREELKELARELGLADKVIFTGFVPREELPEYYKAADLFVFASTTETQGLVY 293


                ...
gi 16129972 291 SEA 293
Cdd:cd03817 294 LEA 296
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
 105-276 6.20e-09

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 56.97  E-value: 6.20e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972 105 YVYCHNPAPF--YKGILFREILMEPSFFLFKMLYGLIYKINIKKNTAVFVQQFWMKEKFIKKYSiNNIIVSRPEIK--LS 180
Cdd:cd03794 101 VIIAYSPPITlgLAALLLKKLRGAPFILDVRDLWPESLIALGVLKKGSLLKLLKKLERKLYRLA-DAIIVLSPGLKeyLL 179

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972 181 DKSQLTD---------DDSQFKNNPSELTIFYPAVPRVFK-----------NYELIISAARKLKEQSNIKFLLTISGTEN 240
Cdd:cd03794 180 RKGVPKEkiivipnwaDLEEFKPPPKDELRKKLGLDDKFVvvyagnigkaqGLETLLEAAERLKRRPDIRFLFVGDGDEK 259

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 16129972 241 AYAKYIISlAEGLDNVHFLGYLDKEKIDHCYNISDI 276
Cdd:cd03794 260 ERLKELAK-ARGLDNVTFLGRVPKEEVPELLSAADV 294
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 181-306 4.72e-08

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 54.20  E-value: 4.72e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972 181 DKSQLTDDDSQFK----NNPSELTIFYPAVPRVFKNYELIISAARKlkeqsnIKFLLTISGTENAYAkYIISLAE--GLD 254
Cdd:cd03795 170 DKNVYNIPRVDFEnikrEKKGKKIFLFIGRLVYYKGLDYLIEAAQY------LNYPIVIGGEGPLKP-DLEAQIElnLLD 242

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 16129972 255 NVHFLGYLDKEKIDHCYNISDIVCFPS--RLETWGLPLSEAKERGKWVLASDFP 306
Cdd:cd03795 243 NVKFLGRVDDEEKVIYLHLCDVFVFPSvlRSEAFGIVLLEAMMCGKPVISTNIG 296
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 196-304 5.84e-08

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 53.92  E-value: 5.84e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972 196 PSELTIFYPAVPRVF---------KNYELIISAARKL-KEQSNIKFLLTISGTENAYAKYIISLAEGLDNVHFLGYLDKE 265
Cdd:cd03798 189 PEDRGLGLPLDAFVIlfvgrliprKGIDLLLEAFARLaKARPDVVLLIVGDGPLREALRALAEDLGLGDRVTFTGRLPHE 268

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 16129972 266 KIDHCYNISDIVCFPSRLETWGLPLSEAKERGKWVLASD 304
Cdd:cd03798 269 QVPAYYRACDVFVLPSRHEGFGLVLLEAMACGLPVVATD 307
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 211-306 1.39e-07

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 52.68  E-value: 1.39e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972 211 KNYELIISAARKLKEQSNIKFLLTISGTENAyakyiiSLAEGLDNVHFLGYLDKEKIDHCYNISDIVCFPSRLETWGLPL 290
Cdd:cd03814 211 KNLEALLDADLPLAASPPVRLVVVGDGPARA------ELEARGPDVIFTGFLTGEELARAYASADVFVFPSRTETFGLVV 284

                        90
                ....*....|....*.
gi 16129972 291 SEAkergkwvLASDFP 306
Cdd:cd03814 285 LEA-------MASGLP 293
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 259-336 1.67e-07

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 49.60  E-value: 1.67e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972 259 LGYLDKEK-----IDHCYNISDIVCFPSRLETWGLPLSEAKERGKWVLASDFPFTRETLGSYEKKAFFDSNNDDMLVKLI 333
Cdd:COG0438   1 MGRLVPRKgldllLEALLAAADVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPPGDPEALAEAI 80


                ...
gi 16129972 334 IDF 336
Cdd:COG0438  81 LRL 83
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 211-336 1.44e-06

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 49.62  E-value: 1.44e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972 211 KNYELIISAARKLKEQ-SNIKFLLTISGTENAYAKyIISLAEGL-DNVHFLGYldKEKIDHCYNISDIVCFPSRLETWGL 288
Cdd:cd03807 203 KDHSDLLRAAALLVEThPDLRLLLVGRGPERPNLE-RLLLELGLeDRVHLLGE--RSDVPALLPAMDIFVLSSRTEGFPN 279

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 16129972 289 PLSEAKERGKWVLASDFPFTRETLGsyEKKAF-FDSNNDDMLVKLIIDF 336
Cdd:cd03807 280 ALLEAMACGLPVVATDVGGAAELVD--DGTGFlVPAGDPQALADAIRAL 326
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 30-344 1.58e-06

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 49.66  E-value: 1.58e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972  30 NNKENVSFIALVHSAKELKESYPWVKFIEFPEVK----GSWLKRLHFEYvvcKKLSKELNATHWICLHDITANVVTK--- 102
Cdd:cd03811  27 KRGYDVTLVLLRDEGDLDKQLNGDVKLIRLLIRVlkliKLGLLKAILKL---KRILKRAKPDVVISFLGFATYIVAKlaa 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972 103 ---KRYVYCHNPapfykgiLFREILMEPSFFLFKMLYGLIYKInikkntaVFVQQfWMKEKFIKKYS--------INNII 171
Cdd:cd03811 104 arsKVIAWIHSS-------LSKLYYLKKKLLLKLKLYKKADKI-------VCVSK-GIKEDLIRLGPsppekievIYNPI 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972 172 vsrpeiklsdksqltdDDSQFKNNPSELTIFYPAVPRVF---------KNYELIISAARKLKEqSNIKFLLTISGtENAY 242
Cdd:cd03811 169 ----------------DIDRIRALAKEPILNEPEDGPVIlavgrldpqKGHDLLIEAFAKLRK-KYPDVKLVILG-DGPL 230

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972 243 AKYIISLAEGL---DNVHFLGYLDkekidhcyNI------SDIVCFPSRLEtwGLP--LSEAKERGKWVLASDFPFTRET 311
Cdd:cd03811 231 REELEKLAKELglaERVIFLGFQS--------NPypylkkADLFVLSSRYE--GFPnvLLEAMALGTPVVSTDCPGPREI 300

                       330       340       350
                ....*....|....*....|....*....|...
gi 16129972 312 LGSYEKKAFFDSNNDDMLVKLIIDFKKGNLKKD 344
Cdd:cd03811 301 LDDGENGLLVPDGDAAALAGILAALLQKKLDAA 333
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 211-306 1.73e-06

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 49.29  E-value: 1.73e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972 211 KNYELIISAARKLKEQSNiKFLLTISGT-ENAYAKYIISLAEGL--DNVHFLGYLDKEKIDHCYNISDIVCFPSRLETWG 287
Cdd:cd03821 217 KGLDLLIRAARKLAEQGR-DWHLVIAGPdDGAYPAFLQLQSSLGlgDRVTFTGPLYGEAKWALYASADLFVLPSYSENFG 295

                        90
                ....*....|....*....
gi 16129972 288 LPLSEAKERGKWVLASDFP 306
Cdd:cd03821 296 NVVAEALACGLPVVITDKC 314
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 211-335 2.41e-05

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 45.81  E-value: 2.41e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972 211 KNYELIISAARKLKEQSNIKFLLTISGTENAYAKYIISLAEGLDNVHFLGYldKEKIDHCYNISDIVCFPSRLETWGLPL 290
Cdd:cd03819 195 KGWLLLVDAAAELKDEPDFRLLVAGDGPERDEIRRLVERLGLRDRVTFTGF--REDVPAALAASDVVVLPSLHEEFGRVA 272

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 16129972 291 SEAKERGKWVLASDFPFTRETLGSYEKKAFFDSNNDDMLVKLIID 335
Cdd:cd03819 273 LEAMACGTPVVATDVGGAREIVVHGRTGLLVPPGDAEALADAIRA 317
MSMEG_0565_glyc TIGR04047
glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from ...
 256-310 6.94e-04

glycosyltransferase, MSMEG_0565 family; A conserved gene cluster found sporadically from Actinobacteria to Proteobacteria to Cyanobacteria features a radical SAM protein, an N-acetyltransferase, an oxidoreductase, and two additional proteins whose functional classes are unclear. The metabolic role of the cluster is probably biosynthetic. This glycosyltransferase, named from member MSMEG_0565 from Mycobacterium smegmatis, occurs in most but not all instances of the cluster. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 274943 [Multi-domain]  Cd Length: 373  Bit Score: 41.23  E-value: 6.94e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 16129972   256 VHFLGYLDKEKIDHCYNISDIVCFPSRLETWGLPLSEAKERGKWVLASDF-PFTRE 310
Cdd:TIGR04047 259 VVITGPVPDADLPALYRCADAFAFPSLKEGFGLVVLEALASGIPVVASDIaPFTEY 314
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
182-303 1.27e-03

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 40.54  E-value: 1.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972  182 KSQLTDDDSQFKNNPSELT-IFYPAVPRVFKNYELIISAARKL-KEQSNIKFLL------TISGTENAYAKYIISLAEGL 253
Cdd:PRK15484 176 QSNPQPNLRQQLNISPDETvLLYAGRISPDKGILLLMQAFEKLaTAHSNLKLVVvgdptaSSKGEKAAYQKKVLEAAKRI 255

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 16129972  254 -DNVHFLGYLDKEKIDHCYNISDIVCFPSRL-ETWGLPLSEAKERGKWVLAS 303
Cdd:PRK15484 256 gDRCIMLGGQPPEKMHNYYPLADLVVVPSQVeEAFCMVAVEAMAAGKPVLAS 307
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 191-305 8.35e-03

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 37.99  E-value: 8.35e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16129972 191 QFKNNPSELTIFYPA--VPRvfKNYELIISAARKLKEQSNIKFLLTISGTEN------AYAKYIISLAEGL-DNVHFLGY 261
Cdd:cd03800 213 RLLLPPDKPVVLALGrlDPR--KGIDTLVRAFAQLPELRELANLVLVGGPSDdplsmdREELAELAEELGLiDRVRFPGR 290

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 16129972 262 LDKEKIDHCYNISDIVCFPSRLETWGLPLSEAKERGKWVLASDF 305
Cdd:cd03800 291 VSRDDLPELYRAADVFVVPSLYEPFGLTAIEAMACGTPVVATAV 334
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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