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Conserved domains on  [gi|16130131|ref|NP_416698|]
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holocytochrome c synthase CcmH component [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

cytochrome c-type biogenesis protein CcmH( domain architecture ID 11459658)

cytochrome c-type biogenesis protein CcmH is a membrane-anchored thiol-oxidoreductase that is essential in the maturation of c-type cytochromes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NrfF COG3088
Cytochrome c-type biogenesis protein CcmH/NrfF [Energy production and conversion, ...
 1-121 3.47e-63

Cytochrome c-type biogenesis protein CcmH/NrfF [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 442322  Cd Length: 149  Bit Score: 197.72  E-value: 3.47e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131   1 MRFLLGVLMLMISGSALATIDVLQFKDEAQEQQFRQLTEELRCPKCQNNSIADSNSMIATDLRQKVYELMQEGKSKKEIV 80
Cdd:COG3088   1 MRRLLLLLALLLAAPAAAVIPDEQFDDPALEARARELSKELRCPVCQNQSIADSNAPLARDLRREVRERLAAGKSDEEIV 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 16130131  81 DYMVARYGNFVTYDPPLTPLTVLLWVLPVVAIGIGGWVIYA 121
Cdd:COG3088  81 DYMVARYGEFVLYKPPLKGATLLLWLGPFLLLLLGLGVLVR 121
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 206-340 1.08e-32

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 118.57  E-value: 1.08e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131 206 RLALGMRTQLQKNPGDIEGWIMLGRVGMALGNASIATDAYATAYRLDPKNSDAALGYAEALTRSSDPNDnrlGGELLRQL 285
Cdd:COG4235   1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEE---AEELLERA 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 16130131 286 VRTDHSNIRVLSMYAFNAFEQQRFGEAVAAWEMMLKLLPANDTRRAvIERSIAQA 340
Cdd:COG4235  78 LALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPARL-LEASIAEA 131
 
Name Accession Description Interval E-value
NrfF COG3088
Cytochrome c-type biogenesis protein CcmH/NrfF [Energy production and conversion, ...
 1-121 3.47e-63

Cytochrome c-type biogenesis protein CcmH/NrfF [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442322  Cd Length: 149  Bit Score: 197.72  E-value: 3.47e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131   1 MRFLLGVLMLMISGSALATIDVLQFKDEAQEQQFRQLTEELRCPKCQNNSIADSNSMIATDLRQKVYELMQEGKSKKEIV 80
Cdd:COG3088   1 MRRLLLLLALLLAAPAAAVIPDEQFDDPALEARARELSKELRCPVCQNQSIADSNAPLARDLRREVRERLAAGKSDEEIV 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 16130131  81 DYMVARYGNFVTYDPPLTPLTVLLWVLPVVAIGIGGWVIYA 121
Cdd:COG3088  81 DYMVARYGEFVLYKPPLKGATLLLWLGPFLLLLLGLGVLVR 121
CcmH pfam03918
Cytochrome C biogenesis protein; Members of this family include NrfF, CcmH, CycL, Ccl2.
 7-121 1.95e-60

Cytochrome C biogenesis protein; Members of this family include NrfF, CcmH, CycL, Ccl2.


Pssm-ID: 461092  Cd Length: 143  Bit Score: 190.79  E-value: 1.95e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131     7 VLMLMISGSALATIDVLQFKDEAQEQQFRQLTEELRCPKCQNNSIADSNSMIATDLRQKVYELMQEGKSKKEIVDYMVAR 86
Cdd:pfam03918   2 LLLLLLALAAAAVIPDEEFDDPAQEARARALSKELRCPVCQNQSIADSNAPLARDLRLEVREMLQAGKSDDEIVDYMVAR 81

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 16130131    87 YGNFVTYDPPLTPLTVLLWVLPVVAIGIGGWVIYA 121
Cdd:pfam03918  82 YGDFVLYKPPFKGATLLLWLGPFLLLLLGALALFL 116
cyt_nit_nrfF TIGR03147
cytochrome c nitrite reductase, accessory protein NrfF; [Energy metabolism, Electron transport]
 3-110 1.49e-34

cytochrome c nitrite reductase, accessory protein NrfF; [Energy metabolism, Electron transport]


Pssm-ID: 274449  Cd Length: 126  Bit Score: 123.32  E-value: 1.49e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131     3 FLLGVLMLMISGSALAT-IDVLQFKDEAQEQQFRQLTEELRCPKCQNNSIADSNSMIATDLRQKVYELMQEGKSKKEIVD 81
Cdd:TIGR03147   2 KFLALLLFLISFSARAQmVDTYQFHNPEQRTRAVALAKSLRCPQCQNQNLVESNSPIAYDLRHEVYSMVDEGKSNQQIID 81

                          90       100
                  ....*....|....*....|....*....
gi 16130131    82 YMVARYGNFVTYDPPLTPLTVLLWVLPVV 110
Cdd:TIGR03147  82 FMTSRFGDFVRYNPPFKWQTLLLWLLPVV 110
CcmH_N cd16378
N-terminal domain of cytochrome c-type biogenesis protein CcmH and related proteins; ...
 30-96 2.65e-34

N-terminal domain of cytochrome c-type biogenesis protein CcmH and related proteins; Cytochrome c-type biogenesis protein CcmH is a membrane-anchored thiol-oxidoreductase that is essential in the maturation of c-type cytochromes. CcmH consists of an N-terminal catalytic domain with the active site CXXC motif and a C-terminal domain of unknown function which is predicted to contain TPR-like repeats. Other members of this family include NrfF, CycL, and Ccl2.


Pssm-ID: 319866  Cd Length: 67  Bit Score: 120.71  E-value: 2.65e-34
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16130131  30 QEQQFRQLTEELRCPKCQNNSIADSNSMIATDLRQKVYELMQEGKSKKEIVDYMVARYGNFVTYDPP 96
Cdd:cd16378   1 QEARARELAKELRCPVCQNQSLADSNAPIARDLRAEIREMLAEGKSDEEILDYLVARYGEFVLYAPP 67
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 206-340 1.08e-32

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 118.57  E-value: 1.08e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131 206 RLALGMRTQLQKNPGDIEGWIMLGRVGMALGNASIATDAYATAYRLDPKNSDAALGYAEALTRSSDPNDnrlGGELLRQL 285
Cdd:COG4235   1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEE---AEELLERA 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 16130131 286 VRTDHSNIRVLSMYAFNAFEQQRFGEAVAAWEMMLKLLPANDTRRAvIERSIAQA 340
Cdd:COG4235  78 LALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPARL-LEASIAEA 131
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 162-326 2.05e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 46.62  E-value: 2.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131   162 GVSYYQTGNYQQVkiwQQATAQAPALLDRALDPKADP----------LNEEEMSRLALGMRTQLQKN-PGDIEGWIMLGR 230
Cdd:TIGR02917 635 ALALLLLADAYAV---MKNYAKAITSLKRALELKPDNteaqiglaqlLLAAKRTESAKKIAKSLQKQhPKAALGFELEGD 711

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131   231 VGMALGNASIATDAYATAYRLDPkNSDAALGYAEALTRSSDPNDnrlGGELLRQLVRTDHSNIRVLSMYAFNAFEQQRFG 310
Cdd:TIGR02917 712 LYLRQKDYPAAIQAYRKALKRAP-SSQNAIKLHRALLASGNTAE---AVKTLEAWLKTHPNDAVLRTALAELYLAQKDYD 787

                         170
                  ....*....|....*.
gi 16130131   311 EAVAAWEMMLKLLPAN 326
Cdd:TIGR02917 788 KAIKHYQTVVKKAPDN 803
PRK10370 PRK10370
formate-dependent nitrite reductase complex subunit NrfG; Provisional
 151-334 8.34e-05

formate-dependent nitrite reductase complex subunit NrfG; Provisional


Pssm-ID: 182415 [Multi-domain]  Cd Length: 198  Bit Score: 42.97  E-value: 8.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131  151 LPGIVVALIVAGVSYYQTGNYQQVKIWQQATAQAPALLDRALDPKADPLNEEEMSRLalgmRTQLQKNPGDIEGWIMLGR 230
Cdd:PRK10370   6 IPVKMLTTLTILMVFLCVGSYLLSPKWQAVRAEYQRLADPLHQFASQQTPEAQLQAL----QDKIRANPQNSEQWALLGE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131  231 VGMALGNASIATDAYATAYRLDPKNSDAALGYAEALTRSSDPNDNRLGGELLRQLVRTDHSNIRVLSMYAFNAFEQQRFG 310
Cdd:PRK10370  82 YYLWRNDYDNALLAYRQALQLRGENAELYAALATVLYYQAGQHMTPQTREMIDKALALDANEVTALMLLASDAFMQADYA 161

                        170       180
                 ....*....|....*....|....
gi 16130131  311 EAVAAWEMMLKLLPANDTRRAVIE 334
Cdd:PRK10370 162 QAIELWQKVLDLNSPRVNRTQLVE 185
 
Name Accession Description Interval E-value
NrfF COG3088
Cytochrome c-type biogenesis protein CcmH/NrfF [Energy production and conversion, ...
 1-121 3.47e-63

Cytochrome c-type biogenesis protein CcmH/NrfF [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442322  Cd Length: 149  Bit Score: 197.72  E-value: 3.47e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131   1 MRFLLGVLMLMISGSALATIDVLQFKDEAQEQQFRQLTEELRCPKCQNNSIADSNSMIATDLRQKVYELMQEGKSKKEIV 80
Cdd:COG3088   1 MRRLLLLLALLLAAPAAAVIPDEQFDDPALEARARELSKELRCPVCQNQSIADSNAPLARDLRREVRERLAAGKSDEEIV 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 16130131  81 DYMVARYGNFVTYDPPLTPLTVLLWVLPVVAIGIGGWVIYA 121
Cdd:COG3088  81 DYMVARYGEFVLYKPPLKGATLLLWLGPFLLLLLGLGVLVR 121
CcmH pfam03918
Cytochrome C biogenesis protein; Members of this family include NrfF, CcmH, CycL, Ccl2.
 7-121 1.95e-60

Cytochrome C biogenesis protein; Members of this family include NrfF, CcmH, CycL, Ccl2.


Pssm-ID: 461092  Cd Length: 143  Bit Score: 190.79  E-value: 1.95e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131     7 VLMLMISGSALATIDVLQFKDEAQEQQFRQLTEELRCPKCQNNSIADSNSMIATDLRQKVYELMQEGKSKKEIVDYMVAR 86
Cdd:pfam03918   2 LLLLLLALAAAAVIPDEEFDDPAQEARARALSKELRCPVCQNQSIADSNAPLARDLRLEVREMLQAGKSDDEIVDYMVAR 81

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 16130131    87 YGNFVTYDPPLTPLTVLLWVLPVVAIGIGGWVIYA 121
Cdd:pfam03918  82 YGDFVLYKPPFKGATLLLWLGPFLLLLLGALALFL 116
cyt_nit_nrfF TIGR03147
cytochrome c nitrite reductase, accessory protein NrfF; [Energy metabolism, Electron transport]
 3-110 1.49e-34

cytochrome c nitrite reductase, accessory protein NrfF; [Energy metabolism, Electron transport]


Pssm-ID: 274449  Cd Length: 126  Bit Score: 123.32  E-value: 1.49e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131     3 FLLGVLMLMISGSALAT-IDVLQFKDEAQEQQFRQLTEELRCPKCQNNSIADSNSMIATDLRQKVYELMQEGKSKKEIVD 81
Cdd:TIGR03147   2 KFLALLLFLISFSARAQmVDTYQFHNPEQRTRAVALAKSLRCPQCQNQNLVESNSPIAYDLRHEVYSMVDEGKSNQQIID 81

                          90       100
                  ....*....|....*....|....*....
gi 16130131    82 YMVARYGNFVTYDPPLTPLTVLLWVLPVV 110
Cdd:TIGR03147  82 FMTSRFGDFVRYNPPFKWQTLLLWLLPVV 110
CcmH_N cd16378
N-terminal domain of cytochrome c-type biogenesis protein CcmH and related proteins; ...
 30-96 2.65e-34

N-terminal domain of cytochrome c-type biogenesis protein CcmH and related proteins; Cytochrome c-type biogenesis protein CcmH is a membrane-anchored thiol-oxidoreductase that is essential in the maturation of c-type cytochromes. CcmH consists of an N-terminal catalytic domain with the active site CXXC motif and a C-terminal domain of unknown function which is predicted to contain TPR-like repeats. Other members of this family include NrfF, CycL, and Ccl2.


Pssm-ID: 319866  Cd Length: 67  Bit Score: 120.71  E-value: 2.65e-34
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16130131  30 QEQQFRQLTEELRCPKCQNNSIADSNSMIATDLRQKVYELMQEGKSKKEIVDYMVARYGNFVTYDPP 96
Cdd:cd16378   1 QEARARELAKELRCPVCQNQSLADSNAPIARDLRAEIREMLAEGKSDEEILDYLVARYGEFVLYAPP 67
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 206-340 1.08e-32

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 118.57  E-value: 1.08e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131 206 RLALGMRTQLQKNPGDIEGWIMLGRVGMALGNASIATDAYATAYRLDPKNSDAALGYAEALTRSSDPNDnrlGGELLRQL 285
Cdd:COG4235   1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEE---AEELLERA 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 16130131 286 VRTDHSNIRVLSMYAFNAFEQQRFGEAVAAWEMMLKLLPANDTRRAvIERSIAQA 340
Cdd:COG4235  78 LALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPARL-LEASIAEA 131
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 211-326 1.23e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 55.97  E-value: 1.23e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131 211 MRTQLQKNPGDIEGWIMLGRVGMALGNASIATDAYATAYRLDPKNSDAALGYAEALTRSSDPNDnrlGGELLRQLVRTDH 290
Cdd:COG4783  27 LEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDE---ALALLEKALKLDP 103

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 16130131 291 SNIRVLSMYAFNAFEQQRFGEAVAAWEMMLKLLPAN 326
Cdd:COG4783 104 EHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 152-330 3.84e-07

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 51.92  E-value: 3.84e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131 152 PGIVVALIVAGVSYYQTGNYQQ-VKIWQQATAQAPALLDrALDPKADPLneEEMSRLALGM---RTQLQKNPGDIEGWIM 227
Cdd:COG3914 109 PDNAEALFNLGNLLLALGRLEEaLAALRRALALNPDFAE-AYLNLGEAL--RRLGRLEEAIaalRRALELDPDNAEALNN 185

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131 228 LGRVGMALGNASIATDAYATAYRLDPKNSDAALGYAEALTRSSDPNDNRLGGELLRQLVRTDHSNIRVLSMY------AF 301
Cdd:COG3914 186 LGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQACDWEVYDRFEELLAALARGPSELSPFALLYlpdddpAE 265

                       170       180
                ....*....|....*....|....*....
gi 16130131 302 NAFEQQRFGEAVAAWEMMLKLLPANDTRR 330
Cdd:COG3914 266 LLALARAWAQLVAAAAAPELPPPPNPRDP 294
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 152-326 7.94e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 49.73  E-value: 7.94e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131 152 PGIVVALIVAGVSYYQTGNYQQ-VKIWQQATAQAP----ALLDRALD-------PKAdplnEEEMSRLalgmrtqLQKNP 219
Cdd:COG2956  39 PETVEAHLALGNLYRRRGEYDRaIRIHQKLLERDPdraeALLELAQDylkagllDRA----EELLEKL-------LELDP 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131 220 GDIEGWIMLGRVGMALGNASIATDAYATAYRLDPKNSDAALGYAEALTRSSDPNDNRlggELLRQLVRTDHSNIRVLSMY 299
Cdd:COG2956 108 DDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAI---EALEKALKLDPDCARALLLL 184

                       170       180
                ....*....|....*....|....*..
gi 16130131 300 AFNAFEQQRFGEAVAAWEMMLKLLPAN 326
Cdd:COG2956 185 AELYLEQGDYEEAIAALERALEQDPDY 211
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 162-326 2.05e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 46.62  E-value: 2.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131   162 GVSYYQTGNYQQVkiwQQATAQAPALLDRALDPKADP----------LNEEEMSRLALGMRTQLQKN-PGDIEGWIMLGR 230
Cdd:TIGR02917 635 ALALLLLADAYAV---MKNYAKAITSLKRALELKPDNteaqiglaqlLLAAKRTESAKKIAKSLQKQhPKAALGFELEGD 711

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131   231 VGMALGNASIATDAYATAYRLDPkNSDAALGYAEALTRSSDPNDnrlGGELLRQLVRTDHSNIRVLSMYAFNAFEQQRFG 310
Cdd:TIGR02917 712 LYLRQKDYPAAIQAYRKALKRAP-SSQNAIKLHRALLASGNTAE---AVKTLEAWLKTHPNDAVLRTALAELYLAQKDYD 787

                         170
                  ....*....|....*.
gi 16130131   311 EAVAAWEMMLKLLPAN 326
Cdd:TIGR02917 788 KAIKHYQTVVKKAPDN 803
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 171-321 2.31e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 45.49  E-value: 2.31e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131 171 YQQVKIWQQATAqapaLLDRALdpKADPLNEEEMSRLALGMRTQ-------------LQKNPGDIEGWIMLGRVGMALGN 237
Cdd:COG2956 120 YEQEGDWEKAIE----VLERLL--KLGPENAHAYCELAELYLEQgdydeaiealekaLKLDPDCARALLLLAELYLEQGD 193

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131 238 ASIATDAYATAYRLDPKNSDAALGYAEALTRSSDPNDnrlGGELLRQLVRTDHSNIRVLSMYAFNAfEQQRFGEAVAAWE 317
Cdd:COG2956 194 YEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEE---ALELLRKALELDPSDDLLLALADLLE-RKEGLEAALALLE 269


                ....
gi 16130131 318 MMLK 321
Cdd:COG2956 270 RQLR 273
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 179-324 2.42e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 44.18  E-value: 2.42e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131 179 QATAQAPALLDRALDPKADPLNEEEMSRLALGMRTQLQKNPGDIEGWIMLGRVGMALGNASIATDAYATAYRLDPKNSDA 258
Cdd:COG5010  11 PLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPEL 90

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16130131 259 ALGYAEALTRSSDPNDNRlggELLRQLVRTDHSNIRVLSMYAFNAFEQQRFGEAVAAWEMMLKLLP 324
Cdd:COG5010  91 YYNLALLYSRSGDKDEAK---EYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 178-306 2.68e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 45.75  E-value: 2.68e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131 178 QQATAQAPALLDRALdpKADPLNEEEMSRLALGMRTQ-------------LQKNPGDIEGWIMLGRVGMALGNASIATDA 244
Cdd:COG3914  91 LGRYEEALALYRRAL--ALNPDNAEALFNLGNLLLALgrleealaalrraLALNPDFAEAYLNLGEALRRLGRLEEAIAA 168

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16130131 245 YATAYRLDPKNSDAALGYAEALTRSSDPNDNRlggELLRQLVRTDHSNIRVLSMYAFNAFEQ 306
Cdd:COG3914 169 LRRALELDPDNAEALNNLGNALQDLGRLEEAI---AAYRRALELDPDNADAHSNLLFALRQA 227
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 152-326 3.98e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 45.46  E-value: 3.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131   152 PGIVVALIVAGVSYYQTGNYQqvkiwqqataQAPALLDRALdpKADPLNEE-----EMSRLALGMRTQ--------LQKN 218
Cdd:TIGR02917 292 PEYLPALLLAGASEYQLGNLE----------QAYQYLNQIL--KYAPNSHQarrllASIQLRLGRVDEaiatlspaLGLD 359

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131   219 PGDIEGWIMLGRVGMALGNASIATDAYATAYRLDPKNSDAALgyAEALTRSSDpNDNRLGGELLRQLVRTDHSNIRVLSM 298
Cdd:TIGR02917 360 PDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAART--QLGISKLSQ-GDPSEAIADLETAAQLDPELGRADLL 436

                         170       180
                  ....*....|....*....|....*...
gi 16130131   299 YAFNAFEQQRFGEAVAAWEMMLKLLPAN 326
Cdd:TIGR02917 437 LILSYLRSGQFDKALAAAKKLEKKQPDN 464
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
215-326 5.92e-05

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 43.84  E-value: 5.92e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131 215 LQKNPGDIEGWIMLGRVGMALGNASIATDAYATAYRLDPKNSDAALGYAEALTRSSDPNDNRlggELLRQLVRTDHSNIR 294
Cdd:COG0457  35 LELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEAL---EDYDKALELDPDDAE 111

                        90       100       110
                ....*....|....*....|....*....|..
gi 16130131 295 VLSMYAFNAFEQQRFGEAVAAWEMMLKLLPAN 326
Cdd:COG0457 112 ALYNLGLALLELGRYDEAIEAYERALELDPDD 143
PRK10370 PRK10370
formate-dependent nitrite reductase complex subunit NrfG; Provisional
 151-334 8.34e-05

formate-dependent nitrite reductase complex subunit NrfG; Provisional


Pssm-ID: 182415 [Multi-domain]  Cd Length: 198  Bit Score: 42.97  E-value: 8.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131  151 LPGIVVALIVAGVSYYQTGNYQQVKIWQQATAQAPALLDRALDPKADPLNEEEMSRLalgmRTQLQKNPGDIEGWIMLGR 230
Cdd:PRK10370   6 IPVKMLTTLTILMVFLCVGSYLLSPKWQAVRAEYQRLADPLHQFASQQTPEAQLQAL----QDKIRANPQNSEQWALLGE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131  231 VGMALGNASIATDAYATAYRLDPKNSDAALGYAEALTRSSDPNDNRLGGELLRQLVRTDHSNIRVLSMYAFNAFEQQRFG 310
Cdd:PRK10370  82 YYLWRNDYDNALLAYRQALQLRGENAELYAALATVLYYQAGQHMTPQTREMIDKALALDANEVTALMLLASDAFMQADYA 161

                        170       180
                 ....*....|....*....|....
gi 16130131  311 EAVAAWEMMLKLLPANDTRRAVIE 334
Cdd:PRK10370 162 QAIELWQKVLDLNSPRVNRTQLVE 185
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
215-326 2.47e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 41.92  E-value: 2.47e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131 215 LQKNPGDIEGWIMLGRVGMALGNASIATDAYATAYRLDPKNSDAALGYAEALTRSSDPNDnrlGGELLRQLVRTDHSNIR 294
Cdd:COG0457   1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEE---ALADYEQALELDPDDAE 77

                        90       100       110
                ....*....|....*....|....*....|..
gi 16130131 295 VLSMYAFNAFEQQRFGEAVAAWEMMLKLLPAN 326
Cdd:COG0457  78 ALNNLGLALQALGRYEEALEDYDKALELDPDD 109
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
152-274 7.63e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 40.38  E-value: 7.63e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131 152 PGIVVALIVAGVSYYQTGNYQQ-VKIWQQATAQAPALLDrALDPKADPLNEEEMSRLALGMRTQ-LQKNPGDIEGWIMLG 229
Cdd:COG0457  39 PDDAEALYNLGLAYLRLGRYEEaLADYEQALELDPDDAE-ALNNLGLALQALGRYEEALEDYDKaLELDPDDAEALYNLG 117

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 16130131 230 RVGMALGNASIATDAYATAYRLDPKNSDAALGYAEALTRSSDPND 274
Cdd:COG0457 118 LALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEE 162
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 215-326 1.11e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.10  E-value: 1.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131 215 LQKNPGDIEGWIMLGRVGMALGNASIATDAYATAYRLDPKNSDAALGYAEALTRSSDPNDNRlggELLRQLVRTDHSNIR 294
Cdd:COG2956  35 LELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAE---ELLEKLLELDPDDAE 111

                        90       100       110
                ....*....|....*....|....*....|..
gi 16130131 295 VLSMYAFNAFEQQRFGEAVAAWEMMLKLLPAN 326
Cdd:COG2956 112 ALRLLAEIYEQEGDWEKAIEVLERLLKLGPEN 143
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
233-325 1.35e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.46  E-value: 1.35e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131 233 MALGNASIATDAYATAYRLDPKNSDAALGYAEALTRSSDPNDnrlgGELLRQLVRTDHSNIRVLSMYAFNAFEQQRFGEA 312
Cdd:COG3063   3 LKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDE----AIALEKALKLDPNNAEALLNLAELLLELGDYDEA 78

                        90
                ....*....|...
gi 16130131 313 VAAWEMMLKLLPA 325
Cdd:COG3063  79 LAYLERALELDPS 91
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 182-344 4.16e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.91  E-value: 4.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131   182 AQAPALLDRALDPKADP-LNEEEMSRLALGMR-----------TQLQKNPGDIEGWIMLGRVGMALGNASIATDAYATAY 249
Cdd:TIGR02917  73 AAAEKELRKALSLGYPKnQVLPLLARAYLLQGkfqqvldelpgKTLLDDEGAAELLALRGLAYLGLGQLELAQKSYEQAL 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131   250 RLDPKNSDAALGYAEALTRSSDPNDNRlggELLRQLVRTDHSNIRVLSMYAFNAFEQQRFGEAVAAWEMMLKLLPANDT- 328
Cdd:TIGR02917 153 AIDPRSLYAKLGLAQLALAENRFDEAR---ALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAv 229

                         170       180
                  ....*....|....*....|.
gi 16130131   329 --RRAVI---ERSIAQAMQHL 344
Cdd:TIGR02917 230 llALATIlieAGEFEEAEKHA 250
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 215-326 8.72e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.14  E-value: 8.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130131   215 LQKNPGDIEGWIMLGRVGMALGNASIATDAYATAYRLDPKNSDAALGYAEALTRSSDPndnRLGGELLRQLVRTDHSNIR 294
Cdd:TIGR02917 526 LTIDPKNLRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQL---KKALAILNEAADAAPDSPE 602

                          90       100       110
                  ....*....|....*....|....*....|..
gi 16130131   295 VLSMYAFNAFEQQRFGEAVAAWEMMLKLLPAN 326
Cdd:TIGR02917 603 AWLMLGRAQLAAGDLNKAVSSFKKLLALQPDS 634
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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