|
Name |
Accession |
Description |
Interval |
E-value |
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
7-606 |
0e+00 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 959.81 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 7 IYPRRLRNQMILMAILMVIVPTLTIGYIVETEGRSAVLSEKEKKLSAVVNLLNQALGDRYDLYI------DLPREERIRA 80
Cdd:PRK11360 1 IYPRSFRNQLILLVILLVIVPTLLIGYILETEGRSAVLSEKEKKLSAVVNLLDQALGGRFDLYLasqgvaDLPREEKIRA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 81 LNAELAPITENITHAFPGIGAGYYNKMLDAIITYAPSALYQNNVGVTIAADHPGREVMRTNTPLVYSGRQVRGDILNSML 160
Cdd:PRK11360 81 LNAELAPVTENITHAYPGIGAGYYSKELDAIITYGPSALYQENVGVRIKADHPGREVMRTNTPLVESGGQVRGGILNSMI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 161 PIERNGEILGYIWANELTEDIRRQAWKMDVRIIIVLTAGLLISLLLIVLFSRRLSANIDIITDGLSTLAQNIPTRLPQLP 240
Cdd:PRK11360 161 PIERNGEVIGYIWANELTEDIRRQAWKMDRRIYAVLAAGLVIGLLLIFLLSRRFSANVDIIKDGLSTLENDLSTRLPPLP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 241 GEMGQISQSVNNLAQALRETRTLNDLIIENAADGVIAIDRQGDVTTMNPAAEVITGYQRHELVGQPYSMLFD-NTQFYSP 319
Cdd:PRK11360 241 GELGEISQAINNLAQALRETRSLNELILESIADGVIAIDRQGKITTMNPAAEVITGLQRHELVGKPYSELFPpNTPFASP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 320 VLDTLEHGTEHVALEISFPGRDRTIELSVTTSRIHNTHGEMIGALVIFSDLTARKETQRRMAQAERLATLGELMAGVAHE 399
Cdd:PRK11360 321 LLDTLEHGTEHVDLEISFPGRDRTIELSVSTSLLHNTHGEMIGALVIFSDLTERKRLQRRVARQERLAALGELVAGVAHE 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 400 VRNPLTAIRGYVQILRQQTSDPIHQEYLSVVLKEIDSINKVIQQLLEFSRPRHSQWQQVSLNALVEETLVLVQTAGVQAR 479
Cdd:PRK11360 401 IRNPLTAIRGYVQIWRQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSRPRESQWQPVSLNALVEEVLQLFQTAGVQAR 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 480 VDFISELDNELSPINADRELLKQVLLNILINAVQAISARGKIRIQTWQYSDSQQAISIEDNGCGIDLSLQKKIFDPFFTT 559
Cdd:PRK11360 481 VDFETELDNELPPIWADPELLKQVLLNILINAVQAISARGKIRIRTWQYSDGQVAVSIEDNGCGIDPELLKKIFDPFFTT 560
|
570 580 590 600
....*....|....*....|....*....|....*....|....*..
gi 16130156 560 KASGTGLGLALSQRIINAHQGDIRVASLPGYGATFTLILPINPQGNQ 606
Cdd:PRK11360 561 KAKGTGLGLALSQRIINAHGGDIEVESEPGVGTTFTLYLPINPQGNQ 607
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
256-602 |
6.64e-124 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 369.95 E-value: 6.64e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 256 ALRETRTLNDLIIENAADGVIAIDRQGDVTTMNPAAEVITGYQRHELVGQPYSMLF-DNTQFYSPVLDTLEHGTEHVALE 334
Cdd:COG3852 1 ALRESEELLRAILDSLPDAVIVLDADGRITYVNPAAERLLGLSAEELLGRPLAELFpEDSPLRELLERALAEGQPVTERE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 335 ISFPGRD-RTIELSVTTSRIHNTHGEmIGALVIFSDLTARKETQRRMAQAERLATLGELMAGVAHEVRNPLTAIRGYVQI 413
Cdd:COG3852 81 VTLRRKDgEERPVDVSVSPLRDAEGE-GGVLLVLRDITERKRLERELRRAEKLAAVGELAAGLAHEIRNPLTGIRGAAQL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 414 LRQQTSDPIHQEYLSVVLKEIDSINKVIQQLLEFSRPRHSQWQQVSLNALVEETLVLVQtAGVQARVDFISELDNELSPI 493
Cdd:COG3852 160 LERELPDDELREYTQLIIEEADRLNNLVDRLLSFSRPRPPEREPVNLHEVLERVLELLR-AEAPKNIRIVRDYDPSLPEV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 494 NADRELLKQVLLNILINAVQAISARGKIRIQTWQYSDSQQA---------ISIEDNGCGIDLSLQKKIFDPFFTTKASGT 564
Cdd:COG3852 239 LGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTRVERQVTLGglrprlyvrIEVIDNGPGIPEEILDRIFEPFFTTKEKGT 318
|
330 340 350
....*....|....*....|....*....|....*...
gi 16130156 565 GLGLALSQRIINAHQGDIRVASLPGYGATFTLILPINP 602
Cdd:COG3852 319 GLGLAIVQKIVEQHGGTIEVESEPGKGTTFRIYLPLEQ 356
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
210-604 |
2.37e-109 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 335.01 E-value: 2.37e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 210 FSRRLSANIDIITDGLSTLAQ-NIPTRLP-QLPGEMGQISQSVNNLAQALRETR-------TLNDLIIENAADGVIAIDR 280
Cdd:COG5000 29 LARRLTRPLRRLAEATRAVAAgDLSVRLPvTGDDEIGELARAFNRMTDQLKEQReeleerrRYLETILENLPAGVIVLDA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 281 QGDVTTMNPAAEVITGYQRHELVGQPYSMLFDNTQFYSPVLDTLEHGTEHVaLEISFPGRdrtIELSVTTSRIHNthgem 360
Cdd:COG5000 109 DGRITLANPAAERLLGIPLEELIGKPLEELLPELDLAELLREALERGWQEE-IELTRDGR---RTLLVRASPLRD----- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 361 IGALVIFSDLTarketqrRMAQAERLATLGELMAGVAHEVRNPLTAIRGYVQILRQQTSDPIH------QEYLSVVLKEI 434
Cdd:COG5000 180 DGYVIVFDDIT-------ELLRAERLAAWGELARRIAHEIKNPLTPIQLSAERLRRKLADKLEedredlERALDTIIRQV 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 435 DSINKVIQQLLEFSRPRHSQWQQVSLNALVEETLVLVQTAGVQARVDFISELDNELSPINADRELLKQVLLNILINAVQA 514
Cdd:COG5000 253 DRLKRIVDEFLDFARLPEPQLEPVDLNELLREVLALYEPALKEKDIRLELDLDPDLPEVLADRDQLEQVLINLLKNAIEA 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 515 ISARGKIRIqTWQYSDSQQAISIEDNGCGIDLSLQKKIFDPFFTTKASGTGLGLALSQRIINAHQGDIRVASLPGYGATF 594
Cdd:COG5000 333 IEEGGEIEV-STRREDGRVRIEVSDNGPGIPEEVLERIFEPFFTTKPKGTGLGLAIVKKIVEEHGGTIELESRPGGGTTF 411
|
410
....*....|
gi 16130156 595 TLILPINPQG 604
Cdd:COG5000 412 TIRLPLAEEA 421
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
255-604 |
1.77e-95 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 301.12 E-value: 1.77e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 255 QALRETRTLNDLIIENAADGVIAIDRQGDVTTMNPAAEVITGYQRHELVGQPYSMLF---DNTQFYSPVLDTLEHGtEHV 331
Cdd:COG5809 134 EALRESEEKFRLIFNHSPDGIIVTDLDGRIIYANPAACKLLGISIEELIGKSILELIhsdDQENVAAFISQLLKDG-GIA 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 332 ALEISFPGRD-RTIELSVTTSRIHNtHGEMIGALVIFSDLTARKETQRRMAQAERLATLGELMAGVAHEVRNPLTAIRGY 410
Cdd:COG5809 213 QGEVRFWTKDgRWRLLEASGAPIKK-NGEVDGIVIIFRDITERKKLEELLRKSEKLSVVGELAAGIAHEIRNPLTSLKGF 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 411 VQILrQQTSDPIHQEYLSVVLKEIDSINKVIQQLLEFSRPRHSQWQQVSLNALVEETLVLVQTAGVQARVDFISELDNEL 490
Cdd:COG5809 292 IQLL-KDTIDEEQKTYLDIMLSELDRIESIISEFLVLAKPQAIKYEPKDLNTLIEEVIPLLQPQALLKNVQIELELEDDI 370
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 491 SPINADRELLKQVLLNILINAVQAISARGKIRIQTWQYSDSQQAISIEDNGCGIDLSLQKKIFDPFFTTKASGTGLGLAL 570
Cdd:COG5809 371 PDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKAEDDDKVVISVTDEGCGIPEERLKKLGEPFYTTKEKGTGLGLMV 450
|
330 340 350
....*....|....*....|....*....|....
gi 16130156 571 SQRIINAHQGDIRVASLPGYGATFTLILPINPQG 604
Cdd:COG5809 451 SYKIIEEHGGKITVESEVGKGTTFSITLPIKLSE 484
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
268-600 |
4.87e-86 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 272.43 E-value: 4.87e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 268 IENAADGVIAIDRQGDVTTMNPAAEVITGYQRHELVGQPYSMLFDntqfyspVLDTLEHGTEHVALEISFPGRDRTIELS 347
Cdd:COG5807 33 FDSILEFVFFIDSKGEILECNDFAEDLYGLSQNEYIGKTFVEEKC-------ILKDEQLYNKEAFDRIEISYLTKNGEFD 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 348 VTTSRIHNTHGEMIGALVIFSDLTARKETQRRMAQAERLATLGELMAGVAHEVRNPLTAIRGYVQILRQQTSDPIHQEYL 427
Cdd:COG5807 106 EIIYPIYYKDGVILGLITVYRDITKRKEAEDKLLRSEKLSVAGELAAGIAHEIRNPLTSIKGFLQLLQESREDSEREEYF 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 428 SVVLKEIDSINKVIQQLLEFSRPRHSQWQQVSLNALVEETLVLVQTAGVQARVDFISELDNELSPINADRELLKQVLLNI 507
Cdd:COG5807 186 NIIISEIDRINTIITELLVLSKPKKFNFKKLNLNDVLEDVIALLSTEAILKNISIKYDLADDEPVINGDKNQLKQVFINL 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 508 LINAVQAISARGKIRIQTWQYSDSQQaISIEDNGCGIDLSLQKKIFDPFFTTKASGTGLGLALSQRIINAHQGDIRVASL 587
Cdd:COG5807 266 IKNAIEAMETGGNITIKTYVEGDFVV-ISVKDEGIGIPEEVLEKIGEPFFTTKEEGTGLGLSICKKIIEEHNGTIEVESK 344
|
330
....*....|...
gi 16130156 588 PGYGATFTLILPI 600
Cdd:COG5807 345 PGKGTTFTIYLPL 357
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
253-600 |
1.87e-82 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 263.20 E-value: 1.87e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 253 LAQALRETRTLNDLIIENAADGVIAIDRQGDVTTMNPAAEVITGYQRHELVGQPYSMLFDNTQFYSPVLDTLEHGTEHVA 332
Cdd:COG4191 4 LLLLLLLLLALLRALALALALLLLLLLLLLALLLLLLALLLALLALLLLLLLLLLLLLLELLLLLLALLGGLLRLLLLLG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 333 LEISFPGRDRTIELSVTTSRIHNTHGEMIGALV--IFSDLTARKETQRRMAQAERLATLGELMAGVAHEVRNPLTAIRGY 410
Cdd:COG4191 84 LLLLLLLEALLLLLLAALDAEENAELEELERDIteLERAEEELRELQEQLVQSEKLAALGELAAGIAHEINNPLAAILGN 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 411 VQILRQQTSDPIHQEYLSVVLKEIDS----INKVIQQLLEFSRPRHSQWQQVSLNALVEETLVLVQTAGVQARVDFISEL 486
Cdd:COG4191 164 AELLRRRLEDEPDPEELREALERILEgaerAAEIVRSLRAFSRRDEEEREPVDLNELIDEALELLRPRLKARGIEVELDL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 487 DNELSPINADRELLKQVLLNILINAVQAI--SARGKIRIQTWQySDSQQAISIEDNGCGIDLSLQKKIFDPFFTTKA--S 562
Cdd:COG4191 244 PPDLPPVLGDPGQLEQVLLNLLINAIDAMeeGEGGRITISTRR-EGDYVVISVRDNGPGIPPEVLERIFEPFFTTKPvgK 322
|
330 340 350
....*....|....*....|....*....|....*...
gi 16130156 563 GTGLGLALSQRIINAHQGDIRVASLPGYGATFTLILPI 600
Cdd:COG4191 323 GTGLGLSISYGIVEKHGGRIEVESEPGGGTTFTITLPL 360
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
256-600 |
2.05e-77 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 254.27 E-value: 2.05e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 256 ALRETRTLNDLIIENAADGVIAIDRQGDVTTMNPAAEVITGYQRHELVGQP---YSMLFDNTQFYSPVLDTLEHGTEHVA 332
Cdd:COG5805 151 ILQEQEERLQTLIENSPDLICVIDTDGRILFINESIERLFGAPREELIGKNlleLLHPCDKEEFKERIESITEVWQEFII 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 333 LE--ISFPGRDRTIElsVTTSRIHNTHGEMIGALVIFSDLTARKETQRRMAQAERLATLGELMAGVAHEVRNPLTAIRGY 410
Cdd:COG5805 231 EReiITKDGRIRYFE--AVIVPLIDTDGSVKGILVILRDITEKKEAEELMARSEKLSIAGQLAAGIAHEIRNPLTSIKGF 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 411 VQILRQQTSDpiHQEYLSVVLKEIDSINKVIQQLLEFSRPRHSQWQQVSLNALVEETLVLVQTagvQARVD---FISELD 487
Cdd:COG5805 309 LQLLQPGIED--KEEYFDIMLSELDRIESIISEFLALAKPQAVNKEKENINELIQDVVTLLET---EAILHniqIRLELL 383
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 488 NELSPINADRELLKQVLLNILINAVQAISARGKIRIQTWQYsDSQQAISIEDNGCGIDLSLQKKIFDPFFTTKASGTGLG 567
Cdd:COG5805 384 DEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEE-DNSVIIRVIDEGIGIPEERLKKLGEPFFTTKEKGTGLG 462
|
330 340 350
....*....|....*....|....*....|...
gi 16130156 568 LALSQRIINAHQGDIRVASLPGYGATFTLILPI 600
Cdd:COG5805 463 LMVSYKIIENHNGTIDIDSKVGKGTTFTITLPL 495
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
320-601 |
3.31e-61 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 206.30 E-value: 3.31e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 320 VLDTLEHGTEHVALEISFPGRDRTIELSVTTSRIHNTHGEMIGALVIFSDLTARKETQRRMAQaERLATLGELMAGVAHE 399
Cdd:COG0642 42 LLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLLALLLLLE-EANEAKSRFLANVSHE 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 400 VRNPLTAIRGYVQILRQQTsDPIHQEYLSVVLKEIDSINKVIQQLLEFSRPRHS----QWQQVSLNALVEETLVLVQTAG 475
Cdd:COG0642 121 LRTPLTAIRGYLELLLEEL-DEEQREYLETILRSADRLLRLINDLLDLSRLEAGklelEPEPVDLAELLEEVVELFRPLA 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 476 VQARVDFISELDNELSPINADRELLKQVLLNILINAVQAISARGKIRIQTwQYSDSQQAISIEDNGCGIDLSLQKKIFDP 555
Cdd:COG0642 200 EEKGIELELDLPDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSV-RREGDRVRISVEDTGPGIPPEDLERIFEP 278
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 16130156 556 FFTTKAS----GTGLGLALSQRIINAHQGDIRVASLPGYGATFTLILPIN 601
Cdd:COG0642 279 FFRTDPSrrggGTGLGLAIVKRIVELHGGTIEVESEPGKGTTFTVTLPLA 328
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
374-603 |
5.04e-57 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 192.04 E-value: 5.04e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 374 KETQRRMAQAERLATlgELMAGVAHEVRNPLTAIRGYVQILRQQT--SDPIHQEYLSVVLKEIDSINKVIQQLLEFSRPR 451
Cdd:COG2205 3 EEALEELEELERLKS--EFLANVSHELRTPLTSILGAAELLLDEEdlSPEERRELLEIIRESAERLLRLIEDLLDLSRLE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 452 HSQW----QQVSLNALVEETLVLVQTAGVQARVDFISELDNELSPINADRELLKQVLLNILINAVQAISARGKIRIQTWQ 527
Cdd:COG2205 81 SGKLslelEPVDLAELLEEAVEELRPLAEEKGIRLELDLPPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 528 YSDSQQaISIEDNGCGIDLSLQKKIFDPFF----TTKASGTGLGLALSQRIINAHQGDIRVASLPGYGATFTLILPINPQ 603
Cdd:COG2205 161 EGDGVR-ISVSDNGPGIPEEELERIFERFYrgdnSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPGGGTTFTVTLPLAES 239
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
243-603 |
1.36e-56 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 195.93 E-value: 1.36e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 243 MGQISQSVNNLAQALRETRTLNDLIIENAADGVIAIDRQGDVTTMNPAAEVITGYQRHELVGQPYSMLFDNTQFYSPVLD 322
Cdd:COG5002 28 LLLLLLLLLLLLLLLLLLLLLLLLLALLLLLLLLLLLLLALLLLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 323 TLEHGTEHVALEISFPGRDRTIELSVTTSRIHNTHGEMIGALVIFSDLTARKETQRRMAqaerlatlgELMAGVAHEVRN 402
Cdd:COG5002 108 LALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLAAVERDITELERLEQMRR---------EFVANVSHELRT 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 403 PLTAIRGYVQILRQQ--TSDPIHQEYLSVVLKEIDSINKVIQQLLEFSR----PRHSQWQQVSLNALVEETLVLVQTAGV 476
Cdd:COG5002 179 PLTSIRGYLELLLDGaaDDPEERREYLEIILEEAERLSRLVNDLLDLSRlesgELKLEKEPVDLAELLEEVVEELRPLAE 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 477 QARVDFISELDNELSPINADRELLKQVLLNILINAVQAISARGKIRIqTWQYSDSQQAISIEDNGCGIDLSLQKKIFDPF 556
Cdd:COG5002 259 EKGIELELDLPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITV-SLREEDDQVRISVRDTGIGIPEEDLPRIFERF 337
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 16130156 557 FTTKAS------GTGLGLALSQRIINAHQGDIRVASLPGYGATFTLILPINPQ 603
Cdd:COG5002 338 YRVDKSrsretgGTGLGLAIVKHIVEAHGGRIWVESEPGKGTTFTITLPLARE 390
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
304-601 |
1.04e-54 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 192.69 E-value: 1.04e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 304 GQPysmLFDNTQFYSPVLDTLEHGTEHV-------ALEISFPGRDRTiELSVTTSRIHNTHGEMIGAL--VIFSDLTA-- 372
Cdd:PRK10364 137 GEP---VLEIYRQFQPMFAAGMHGMRHMqqyaaanTPQAIFIAFDAS-NLVSAQAREQRNTLIILFALatVLLASLLAff 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 373 --------RKETQRRMAQAERLATLGELMAGVAHEVRNPLTAIRGYVQILRQQTSDPIH-QEYLSVVLKEIDSINKVIQQ 443
Cdd:PRK10364 213 wyrrylrsRQLLQDEMKRKEKLVALGHLAAGVAHEIRNPLSSIKGLAKYFAERAPAGGEaHQLAQVMAKEADRLNRVVSE 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 444 LLEFSRPRHSQWQQVSLNALVEETLVLV----QTAGVQARVdfisELDNELSPINADRELLKQVLLNILINAVQAISARG 519
Cdd:PRK10364 293 LLELVKPTHLALQAVDLNDLINHSLQLVsqdaNSREIQLRF----TANDTLPEIQADPDRLTQVLLNLYLNAIQAIGQHG 368
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 520 KIRIqTWQYSDSQQAISIEDNGCGIDLSLQKKIFDPFFTTKASGTGLGLALSQRIINAHQGDIRVASLPGYGATFTLILP 599
Cdd:PRK10364 369 VISV-TASESGAGVKISVTDSGKGIAADQLEAIFTPYFTTKAEGTGLGLAVVHNIVEQHGGTIQVASQEGKGATFTLWLP 447
|
..
gi 16130156 600 IN 601
Cdd:PRK10364 448 VN 449
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
497-600 |
1.80e-54 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 180.31 E-value: 1.80e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 497 RELLKQVLLNILINAVQAISARGKIRIQTWQYSDsQQAISIEDNGCGIDLSLQKKIFDPFFTTK--ASGTGLGLALSQRI 574
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAMEGRGRITIRTWAHVD-QVLIEVEDTGSGIDPEILGRIFDPFFTTKpvGEGTGLGLSLSYRI 79
|
90 100
....*....|....*....|....*.
gi 16130156 575 INAHQGDIRVASLPGYGATFTLILPI 600
Cdd:cd16943 80 IQKHGGTIRVASVPGGGTRFTIILPI 105
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
360-599 |
2.28e-51 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 182.37 E-value: 2.28e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 360 MIGALVIFSDLTARKETQRRMAQAERLATLGELMAGVAHEVRNPLTAIRGYVQILRQ-QTSDPIHQEYLSVVLKEIDSIN 438
Cdd:COG5806 172 MLIAVYLIENLIENILLRKELQRAEKLEVVSELAASIAHEVRNPLTVVRGFIQLLQEpELSDEKRKQYIRIALEELDRAE 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 439 KVIQQLLEFSRPRHSQWQQVSLNALVEETLVLVQTAGVQARVDFISELDNELSpINADRELLKQVLLNILINAVQAISAR 518
Cdd:COG5806 252 AIITDYLTFAKPQPEKLEKIDVSEELEHVIDVLSPYANMNNVEIQTELEPGLY-IEGDRQKLQQCLINIIKNGIEAMPNG 330
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 519 GKIRIQTwqYSDSQQA-ISIEDNGCGIDLSLQKKIFDPFFTTKASGTGLGLALSQRIINAHQGDIRVASLPGYGATFTLI 597
Cdd:COG5806 331 GTLTIDV--SIDKNKViISIKDTGVGMTKEQLERLGEPYFSTKEKGTGLGTMVSYRIIEAMNGTIRVESEVGKGTTFTIT 408
|
..
gi 16130156 598 LP 599
Cdd:COG5806 409 LP 410
|
|
| KinD |
COG5808 |
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome ... |
373-600 |
5.03e-51 |
|
Sporulation sensor histidine kinase D [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444510 [Multi-domain] Cd Length: 454 Bit Score: 182.64 E-value: 5.03e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 373 RKETQRRMAQA---ERLATLGELMAGVAHEVRNPLTAIRGYVQILRQQTSDPIHQEYLSVVLKEIDSINKVIQQLLEFSR 449
Cdd:COG5808 222 RKTLLERVIQEintQKLELIGTFAASTAHEIRNPLTSIKGFIQLLQEKYPELEDQKYFDIIQEEIQRINQIVSEFLVLGK 301
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 450 PRHSQWQQVSLNALVEETLVLVQTAGVQARVDFISELDNELSPINADRELLKQVLLNILINAVQAISARGKIRIQTWQYS 529
Cdd:COG5808 302 PTAKKLELDDLNELIEEILSIIDSEANLKNIRVEKQSLDEPLHIKCDKDRIKQVLLNLIKNAIEAMKEGGKLTISIENDD 381
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16130156 530 DSQQaISIEDNGCGIDLSLQKKIFDPFFTTKASGTGLGLALSQRIINAHQGDIRVASLPGYGATFTLILPI 600
Cdd:COG5808 382 EKAV-IEVIDNGEGIPEDIIDEIFEPFVTTKEGGTGLGLSVCKRIVEMHGGEIDIESEEGKGTTFTIRLPL 451
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
372-603 |
3.02e-41 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 160.23 E-value: 3.02e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 372 ARKETQR-----RMAQAERLATLGELMAGVAHEVRNPLTAIRGYVQI-LRQQTSDPIHQEYLSVVLKEIDSINKVIQQLL 445
Cdd:PRK13837 428 RRLETERdalerRLEHARRLEAVGTLASGIAHNFNNILGAILGYAEMaLNKLARHSRAARYIDEIISAGARARLIIDQIL 507
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 446 EFSRPRHSQWQQVSLNALVEETLVLVqTAGVQARVDFISELDNELSPINADRELLKQVLLNILINAVQAISARGKIRIQT 525
Cdd:PRK13837 508 AFGRKGERNTKPFDLSELVTEIAPLL-RVSLPPGVELDFDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISL 586
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 526 WQYSDSQQA--------------ISIEDNGCGIDLSLQKKIFDPFFTTKASGTGLGLALSQRIINAHQGDIRVASLPGYG 591
Cdd:PRK13837 587 SRAKLRAPKvlshgvlppgryvlLRVSDTGAGIDEAVLPHIFEPFFTTRAGGTGLGLATVHGIVSAHAGYIDVQSTVGRG 666
|
250
....*....|..
gi 16130156 592 ATFTLILPINPQ 603
Cdd:PRK13837 667 TRFDVYLPPSSK 678
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
162-603 |
2.27e-40 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 154.17 E-value: 2.27e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 162 IERNGEILGYIWANELTEDIRRQAWKMDVRIIIVLTAGLLISLLLIVLFSRRLSANIDIITDGLSTLAQNIPTRLPQLPG 241
Cdd:COG4251 45 LLLIRLLLLLLLSLLALLLLLLLLLLLLLVLAALALLLLLLLLELALVLLALLLVLLLLLALLLLLALLLLLELLLLLLA 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 242 EMGQISQSVNNLAQALRETRTLNDLIIENAADGVIAIDRQGDVTTMNPAAEVITGYQRHELVGQPYSMLFDNTQFYSPVL 321
Cdd:COG4251 125 LLLLLLLLALLLLEELALLRLALALLLLLLLLLLLLLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLR 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 322 DTLEHGTEHVALEISFPGRDRTIELSVTTSRIHNTHGEMIGALVIFSDLTARKETQRRMAQAERLATLGELMA------- 394
Cdd:COG4251 205 LLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLLLLILLLLLLILVLELLELRLELEELEEELEERTAELERsneeleq 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 395 ---GVAHEVRNPLTAIRGYVQILRQQTS---DPIHQEYLSVVLKEIDSINKVIQQLLEFSR--PRHSQWQQVSLNALVEE 466
Cdd:COG4251 285 fayVASHDLREPLRKISGFSQLLEEDYGdklDEEGREYLERIRDAAERMQALIDDLLAYSRvgRQELEFEPVDLNELLEE 364
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 467 TLVLVQTAGVQARVDFISEldnELSPINADRELLKQVLLNILINAV--QAISARGKIRIqTWQYSDSQQAISIEDNGCGI 544
Cdd:COG4251 365 VLEDLEPRIEERGAEIEVG---PLPTVRGDPTLLRQVFQNLISNAIkySRPGEPPRIEI-GAEREGGEWVFSVRDNGIGI 440
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16130156 545 DLSLQKKIFDPFFT----TKASGTGLGLALSQRIINAHQGDIRVASLPGYGATFTLILPINPQ 603
Cdd:COG4251 441 DPEYAEKIFEIFQRlhsrDEYEGTGIGLAIVKKIVERHGGRIWVESEPGEGATFYFTLPKAPA 503
|
|
| T2SS_HK |
NF038348 |
histidine kinase; |
370-600 |
1.98e-39 |
|
histidine kinase;
Pssm-ID: 439642 [Multi-domain] Cd Length: 574 Bit Score: 152.41 E-value: 1.98e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 370 LTARKETQRRMAQAERLATLGELMAGVAHEVRNP-------LTAIRGYVQIL--------------------------RQ 416
Cdd:NF038348 308 IHELEETHVQLLQSEKLASIGQLAAGVAHEINNPigfvsanLNTLKGWVHSLldviaaqeaatpahaaqtraplaaagRD 387
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 417 QTSDPIHQEYLSVVLKEIDS---INKVIQQLLEFSRPRHSQWQQVSLNALVEETLVLVQTAgVQARVDFISELdNELSPI 493
Cdd:NF038348 388 ADLDYVRGDIMTLIDESIDGamrVRRIVQDLRDFSRPSGDEWSFADLHAGLESTLNVVHNE-LKYKADVVREY-GDLPLV 465
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 494 NADRELLKQVLLNILINAVQAISARGKIRIQTWQYSDSQqAISIEDNGCGIDLSLQKKIFDPFFTTK--ASGTGLGLALS 571
Cdd:NF038348 466 ECNAAQLNQVFMNLLVNAAQAIPGRGTITIRTTCDGDHA-SIAISDTGKGIPPDVMGRIFDPFFTTKpvGQGTGLGLSIS 544
|
250 260
....*....|....*....|....*....
gi 16130156 572 QRIINAHQGDIRVASLPGYGATFTLILPI 600
Cdd:NF038348 545 HGIVEHHRGRIDVASEPGRGSTFTITLPV 573
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
260-600 |
2.30e-39 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 147.53 E-value: 2.30e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 260 TRTLNDLIIENAADGVIAIDRQGDVTTMNPAAEVITGYQRHELVGQPYSMLFDNTQFYSPVL-DTLEHGTEHVALEISFP 338
Cdd:PRK11073 5 TLPDAGQILNSLINSILLLDDDLAIHYANPAAQQLLAQSSRKLFGTPLPELLSYFSLNIELMrESLQAGQGFTDNEVTLV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 339 GRDRTIELSVTTSRIHNthgemigaLVIFSDLtARKETQRRMAQ-----AERLATlGELMAGVAHEVRNPLTAIRGYVQI 413
Cdd:PRK11073 85 IDGRSHILSLTAQRLPE--------GMILLEM-APMDNQRRLSQeqlqhAQQVAA-RDLVRGLAHEIKNPLGGLRGAAQL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 414 LRQQTSDPIHQEYLSVVLKEIDSINKVIQQLLEFSRPRHSQWQqvSLNALVEETLVLVQTAgVQARVDFISELDNELSPI 493
Cdd:PRK11073 155 LSKALPDPALTEYTKVIIEQADRLRNLVDRLLGPQRPGTHVTE--SIHKVAERVVQLVSLE-LPDNVRLIRDYDPSLPEL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 494 NADRELLKQVLLNILINAVQAISAR-GKIRIQTwqySDSQQA------------ISIEDNGCGIDLSLQKKIFDPFFTTK 560
Cdd:PRK11073 232 AHDPDQIEQVLLNIVRNALQALGPEgGTITLRT---RTAFQLtlhgeryrlaarIDIEDNGPGIPPHLQDTLFYPMVSGR 308
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 16130156 561 ASGTGLGLALSQRIINAHQGDIRVASLPGYgATFTLILPI 600
Cdd:PRK11073 309 EGGTGLGLSIARNLIDQHSGKIEFTSWPGH-TEFSVYLPI 347
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
246-603 |
1.27e-36 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 141.14 E-value: 1.27e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 246 ISQSVNNLAQALRETRTLNDLIIENAADGVIAIDRQGDVTTMNPAAEVITGYqrhELVGQPYSMLFDNtqfyspVLDTLE 325
Cdd:COG3290 68 LAALLLKLLEEIARLVEEREAVLESIREGVIAVDRDGRITLINDAARRLLGL---DAIGRPIDEVLAE------VLETGE 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 326 HGTEHVAleisfpgrdRTIELSVTTSRIHNtHGEMIGALVIFSDLTARKETQRRMAQAERLAtlgELMAGVAHEVRNPLT 405
Cdd:COG3290 139 RDEEILL---------NGRVLVVNRVPIRD-DGRVVGAVATFRDRTELERLEEELEGVKELA---EALRAQRHDFRNHLH 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 406 AIRGYVQILRqqtsdpiHQEylsvVLKEIDSINKVIQQLLEFSRPRHsqwQQVSLNALVEETLVLVQTAGVQARVDFise 485
Cdd:COG3290 206 TISGLLQLGE-------YDE----ALEYIDEISEELQELIDSLLSRI---GNPVLAALLLGKAARARERGIDLTIDI--- 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 486 lDNELSPINADRELLKQVLLNILINAVQAISA----RGKIRIQTwQYSDSQQAISIEDNGCGIDLSLQKKIFDPFFTTKA 561
Cdd:COG3290 269 -DSDLPDLPLSDTDLVTILGNLLDNAIEAVEKlpeeERRVELSI-RDDGDELVIEVEDSGPGIPEELLEKIFERGFSTKL 346
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 16130156 562 S-GTGLGLALSQRIINAHQGDIRVASLPGYGATFTLILPINPQ 603
Cdd:COG3290 347 GeGRGLGLALVKQIVEKYGGTIEVESEEGEGTVFTVRLPKEGE 389
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
495-600 |
7.40e-31 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 116.21 E-value: 7.40e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 495 ADRELLKQVLLNILINAVQAISARGKIRIQTWQySDSQQAISIEDNGCGIDLSLQKKIFDPFFTTKA-----SGTGLGLA 569
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLER-DGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDKrsrkiGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|.
gi 16130156 570 LSQRIINAHQGDIRVASLPGYGATFTLILPI 600
Cdd:smart00387 80 IVKKLVELHGGEISVESEPGGGTTFTITLPL 110
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
373-586 |
1.16e-30 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 127.11 E-value: 1.16e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 373 RKETQRRMAQAERLATLGELMAGVAHEVRNPLTAIRGYVQILR---QQTSDPIHQEYLSVVLKEIDSINKVIQQLLEFSR 449
Cdd:COG4192 417 LRQTQDELIQAAKMAVVGQTMTSLAHELNQPLNAMSMYLFSAKkalEQENYAQLPTSLDKIEGLIERMDKIIKSLRQFSR 496
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 450 PRHSQWQQVSLNALVEETLVLVQTagvQARVDFISELDNELSPINADRELLKQVLLNILINAVQAISARGKIRIQtWQYS 529
Cdd:COG4192 497 KSDTPLQPVDLRQVIEQAWELVES---RAKPQQITLHIPDDLMVQGDQVLLEQVLVNLLVNALDAVATQPQISVD-LLSN 572
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 16130156 530 DSQQAISIEDNGCGIDLSlqKKIFDPFFTTKASGTGLGLALSQRIINAHQGDIRVAS 586
Cdd:COG4192 573 AENLRVAISDNGNGWPLV--DKLFTPFTTTKEVGLGLGLSICRSIMQQFGGDLYLAS 627
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
351-600 |
1.87e-29 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 122.86 E-value: 1.87e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 351 SRIHNTHGEmigaLVIFS----DLTARKETQRRMAQAERLATLGELMAGVAHEVRNPLTAIRGYVQILRQQTSDPIHQey 426
Cdd:PRK13557 125 SPVYNDAGD----LVYFFgsqlDVSRRRDAEDALRQAQKMEALGQLTGGIAHDFNNLLQVMSGYLDVIQAALSHPDAD-- 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 427 LSVVLKEIDSI-------NKVIQQLLEFSRPRHSQWQQVSLNALVEETLVLV-QTAGVQARVDfiSELDNELSPINADRE 498
Cdd:PRK13557 199 RGRMARSVENIraaaeraATLTQQLLAFARKQRLEGRVLNLNGLVSGMGELAeRTLGDAVTIE--TDLAPDLWNCRIDPT 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 499 LLKQVLLNILINAVQAISARGKIRIQTWQYSDSQQ--------------AISIEDNGCGIDLSLQKKIFDPFFTTKASGT 564
Cdd:PRK13557 277 QAEVALLNVLINARDAMPEGGRVTIRTRNVEIEDEdlamyhglppgryvSIAVTDTGSGMPPEILARVMDPFFTTKEEGK 356
|
250 260 270
....*....|....*....|....*....|....*...
gi 16130156 565 GLGLALSQRIINAHQ--GDIRVASLPGYGATFTLILPI 600
Cdd:PRK13557 357 GTGLGLSMVYGFAKQsgGAVRIYSEVGEGTTVRLYFPA 394
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
377-600 |
5.26e-29 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 118.90 E-value: 5.26e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 377 QRRMAQAERLATLGELMAGVAHEVRNPLTAIRGYVQILRQQTSDPIHQEYLS-------VVLKEIDSINKVIQQLLEFSR 449
Cdd:PRK09303 139 QENETLLEQLKFKDRVLAMLAHDLRTPLTAASLALETLELGQIDEDTELKPAlieqlqdQARRQLEEIERLITDLLEVGR 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 450 PRHSQW----QQVSLNALVEETLVLVQTAGVQARVDFISELDNELSPINADRELLKQVLLNILINAVQAISARGKIRIQT 525
Cdd:PRK09303 219 TRWEALrfnpQKLDLGSLCQEVILELEKRWLAKSLEIQTDIPSDLPSVYADQERIRQVLLNLLDNAIKYTPEGGTITLSM 298
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16130156 526 WQYSDSQQAISIEDNGCGIDLSLQKKIFDPFFTTK----ASGTGLGLALSQRIINAHQGDIRVASLPGYGATFTLILPI 600
Cdd:PRK09303 299 LHRTTQKVQVSICDTGPGIPEEEQERIFEDRVRLPrdegTEGYGIGLSVCRRIVRVHYGQIWVDSEPGQGSCFHFTLPV 377
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
397-600 |
1.12e-28 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 119.56 E-value: 1.12e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 397 AHEVRNPLTAIRGYVQILRQQTSDPIHQEYLSVVLKEIDSINKVIQQLLEFSRPRHSQW----QQVSLNALVEETLVLVQ 472
Cdd:PRK11100 264 THELKSPLAAIRGAAELLQEDPPPEDRARFTGNILTQSARLQQLIDRLLELARLEQRQElevlEPVALAALLEELVEARE 343
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 473 TAGVQARVDFisELDNELSPINADRELLKQVLLNILINAVQAISARGKIRIQTWQySDSQQAISIEDNGCGIDLSLQKKI 552
Cdd:PRK11100 344 AQAAAKGITL--RLRPDDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEV-DGEQVALSVEDQGPGIPDYALPRI 420
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 16130156 553 FDPFFT-----TKASGTGLGLALSQRIINAHQGDIRVASLPGYGATFTLILPI 600
Cdd:PRK11100 421 FERFYSlprpaNGRKSTGLGLAFVREVARLHGGEVTLRNRPEGGVLATLTLPR 473
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
495-602 |
5.03e-27 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 105.53 E-value: 5.03e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 495 ADRELLKQVLLNILINAVQAISARGKIRIQTWQysDSQQAISIEDNGCGIDLSLQKKIFDPFFT---TKASGTGLGLALS 571
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSE--GGELTLTVEDNGIGIPPEDLPRIFEPFSTadkRGGGGTGLGLSIV 78
|
90 100 110
....*....|....*....|....*....|.
gi 16130156 572 QRIINAHQGDIRVASLPGYGATFTLILPINP 602
Cdd:pfam02518 79 RKLVELLGGTITVESEPGGGTTVTLTLPLAQ 109
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
500-599 |
1.48e-25 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 101.42 E-value: 1.48e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 500 LKQVLLNILINAVQaISARGKIRIQTWQYSDSQQA----ISIEDNGCGIDLSLQKKIFDPF------FTTKASGTGLGLA 569
Cdd:cd16922 1 LRQILLNLLGNAIK-FTEEGEVTLRVSLEEEEEDGvqlrFSVEDTGIGIPEEQQARLFEPFsqadssTTRKYGGTGLGLA 79
|
90 100 110
....*....|....*....|....*....|
gi 16130156 570 LSQRIINAHQGDIRVASLPGYGATFTLILP 599
Cdd:cd16922 80 ISKKLVELMGGDISVESEPGQGSTFTFTLP 109
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
500-599 |
8.98e-25 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 99.01 E-value: 8.98e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 500 LKQVLLNILINAVQAISA----RGKIRIQTWQYSDSQQAISIEDNGCGIDLSLQKKIFDPFFTTKASGTGLGLALSQRII 575
Cdd:cd16920 1 IQQVLINLVRNGIEAMSEggceRRELTIRTSPADDRAVTISVKDTGPGIAEEVAGQLFDPFYTTKSEGLGMGLSICRSII 80
|
90 100
....*....|....*....|....
gi 16130156 576 NAHQGDIRVASLPGYGATFTLILP 599
Cdd:cd16920 81 EAHGGRLSVESPAGGGATFQFTLP 104
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
375-601 |
1.96e-24 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 108.58 E-value: 1.96e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 375 ETQRRMAQAERLATlgELMAGVAHEVRNPLTAIRGYVQILRQQTSDPIHQEYLSVVLKEIDSINKVIQQLLEFSRPRHSQ 454
Cdd:PRK15347 386 EAKQRAEQANKRKS--EHLTTISHEIRTPLNGVLGALELLQNTPLTAEQMDLADTARQCTLSLLAIINNLLDFSRIESGQ 463
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 455 ----WQQVSLNALVEETLVLVQTAGVQARVD---FISE---LDNELSPINadrelLKQVLLNILINAVQAISArGKIRIQ 524
Cdd:PRK15347 464 mtlsLEETALLPLLDQAMLTIQGPAQSKSLTlrtFVGAhvpLYLHLDSLR-----LRQILVNLLGNAVKFTET-GGIRLR 537
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16130156 525 TWQySDSQQAISIEDNGCGIDLSLQKKIFDPFFTT--KASGTGLGLALSQRIINAHQGDIRVASLPGYGATFTLILPIN 601
Cdd:PRK15347 538 VKR-HEQQLCFTVEDTGCGIDIQQQQQIFTPFYQAdtHSQGTGLGLTIASSLAKMMGGELTLFSTPGVGSCFSLVLPLN 615
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
392-584 |
5.39e-24 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 104.99 E-value: 5.39e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 392 LMAGVAHEVRNPLTAIRGYVQILRQQtsdpihQEYL--SVVlKEIDSINKVIQQLLEFSRP-RHSQWQQVSLNALVEETl 468
Cdd:PRK09467 232 LMAGVSHDLRTPLTRIRLATEMMSEE------DGYLaeSIN-KDIEECNAIIEQFIDYLRTgQEMPMEMADLNALLGEV- 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 469 vlvqtagVQARVDFISELDNELSP----INADRELLKQVLLNILINAVQaiSARGKIRIQTwqYSDSQQA-ISIEDNGCG 543
Cdd:PRK09467 304 -------IAAESGYEREIETALQPgpieVPMNPIAIKRALANLVVNAAR--YGNGWIKVSS--GTEGKRAwFQVEDDGPG 372
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 16130156 544 IDLSLQKKIFDPFftTK------ASGTGLGLALSQRIINAHQGDIRV 584
Cdd:PRK09467 373 IPPEQLKHLFQPF--TRgdsargSSGTGLGLAIVKRIVDQHNGKVEL 417
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
288-601 |
3.82e-23 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 104.25 E-value: 3.82e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 288 NPAAEVITGYQRHELVGQPYSMLFDNtQFYSPVLDTLEHGTEH-VALEIS----FP-GRDRTIELSVTT--SRIHNTHGe 359
Cdd:PRK11091 181 NRAMELLTGKSEKQLIGLTPKDVYSP-EAAEKVIETDEKVFRHnVSLTYEqwldYPdGRKACFELRKVPfyDRVGKRHG- 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 360 migaLVIFS-DLTARKETQRRMAQAERLATlgELMAGVAHEVRNPLTAIRGYVQILRQQTSDPIHQEYLS------VVLK 432
Cdd:PRK11091 259 ----LMGFGrDITERKRYQDALEKASRDKT--TFISTISHELRTPLNGIVGLSRILLDTELTAEQRKYLKtihvsaITLG 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 433 EI--DSIN--KVIQQLLEFSRprhsqwQQVSLNALVEEtlvLVQTAGVQAR---VDFISELDNELSP-INADRELLKQVL 504
Cdd:PRK11091 333 NIfnDIIDmdKMERRKLQLDN------QPIDFTDFLAD---LENLSGLQAEqkgLRFDLEPLLPLPHkVITDGTRLRQIL 403
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 505 LNILINAVQaISARGKIRIQTWQYSDSQQAISIEDNGCGIDLSLQKKIFDPFFTTK-------ASGTGLGLALSQRIINA 577
Cdd:PRK11091 404 WNLISNAVK-FTQQGGVTVRVRYEEGDMLTFEVEDSGIGIPEDELDKIFAMYYQVKdshggkpATGTGIGLAVSKRLAQA 482
|
330 340
....*....|....*....|....
gi 16130156 578 HQGDIRVASLPGYGATFTLILPIN 601
Cdd:PRK11091 483 MGGDITVTSEEGKGSCFTLTIHAP 506
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
393-600 |
3.17e-21 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 98.44 E-value: 3.17e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 393 MAGVAHEVRNPLTAIRGYVQILRQQTSDPIHQEYLSVVLKEIDSINKVIQQLLEFSRPRHSQwQQVSLN-------ALVE 465
Cdd:PRK11466 448 LAAMSHEIRTPLYGILGTAQLLADNPALNAQRDDLRAITDSGESLLTILNDILDYSAIEAGG-KNVSVSdepfeprPLLE 526
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 466 ETLVLVQTAGVQARVDFISELDNEL-SPINADRELLKQVLLNILINAVQaISARGKIRIQTwQYSDSQQAISIEDNGCGI 544
Cdd:PRK11466 527 STLQLMSGRVKGRPIRLATDIADDLpTALMGDPRRIRQVITNLLSNALR-FTDEGSIVLRS-RTDGEQWLVEVEDSGCGI 604
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 16130156 545 DLSLQKKIFDPF--FTTKASGTGLGLALSQRIINAHQGDIRVASLPGYGATFTLILPI 600
Cdd:PRK11466 605 DPAKLAEIFQPFvqVSGKRGGTGLGLTISSRLAQAMGGELSATSTPEVGSCFCLRLPL 662
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
500-599 |
4.73e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 85.53 E-value: 4.73e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 500 LKQVLLNILINAVQAISAR-GKIRIQT---WQYSDSQQA------ISIEDNGCGIDLSLQKKIFDPFFTTKASGTGLGLA 569
Cdd:cd16918 1 LIQVFLNLVRNAAQALAGSgGEIILRTrtqRQVTLGHPRhrlalrVSVIDNGPGIPPDLQDTIFYPMVSGRENGTGLGLA 80
|
90 100 110
....*....|....*....|....*....|
gi 16130156 570 LSQRIINAHQGDIRVASLPGYgATFTLILP 599
Cdd:cd16918 81 IAQNIVSQHGGVIECDSQPGH-TVFSVSLP 109
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
500-598 |
9.15e-20 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 84.43 E-value: 9.15e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 500 LKQVLLNILINAVQAIS--ARGKIRIQTwQYSDSQQAISIEDNGCGIDLSLQKKIFDPFFTTK--ASGTGLGLALSQRII 575
Cdd:cd16976 1 IQQVLMNLLQNALDAMGkvENPRIRIAA-RRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKpvGKGTGLGLSISYGIV 79
|
90 100
....*....|....*....|...
gi 16130156 576 NAHQGDIRVASLPGYGATFTLIL 598
Cdd:cd16976 80 EEHGGRLSVANEEGAGARFTFDL 102
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
265-369 |
1.03e-19 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 84.78 E-value: 1.03e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 265 DLIIENAADGVIAIDRQGDVTTMNPAAEVITGYQRHELVGQPYSMLF---DNTQFYSPVLDTLEHGTEHVALEISFPGRD 341
Cdd:pfam00989 4 RAILESLPDGIFVVDEDGRILYVNAAAEELLGLSREEVIGKSLLDLIpeeDDAEVAELLRQALLQGEESRGFEVSFRVPD 83
|
90 100
....*....|....*....|....*....
gi 16130156 342 -RTIELSVTTSRIHNTHGEMIGALVIFSD 369
Cdd:pfam00989 84 gRPRHVEVRASPVRDAGGEILGFLGVLRD 112
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
274-606 |
1.54e-19 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 92.28 E-value: 1.54e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 274 GVIAIDRQGDVTTMNPAAEVITGYqrheLVGQPYSMLFDNTQFYSPVLD---TLEHGTEHVALEISFPGRdrtiELSVTT 350
Cdd:PRK11086 233 GVIAVDDRGEVTLINDEAKRLFNY----KKGLEDDPLGTDVESWMPVSRlkeVLRTGTPRRDEEININGR----LLLTNT 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 351 SRIHNtHGEMIGALVIFSDLTARKEtqrrmaQAERLatlgelmagvahevrnplTAIRGYVQILRQQTsdpiHqEY---L 427
Cdd:PRK11086 305 VPVRV-NGEIIGAIATFRDKTEVRQ------LAQRL------------------DGMVNYADALRAQS----H-EFmnkL 354
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 428 SVVL-----KEIDSINKVIQQLlefsrprhSQWQQVSLNALVE--ETLVLvqtAG-VQARVDFISELDNELS-------P 492
Cdd:PRK11086 355 HVILgllhlKSYDQLEDYILKT--------ANNYQEEIGSLLGkiKSPVI---AGfLLGKISRARELGITLIisedsqlP 423
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 493 INADREL---LKQVLLNILINAVQAISARGKIRIQ-TWQYSDSQQAISIEDNGCGIDLSLQKKIFDPFFTTKASGTGLGL 568
Cdd:PRK11086 424 DSGDEDQvheLITILGNLIENALEAVGGEEGGEISvSLHYRNGWLHCEVSDDGPGIAPDEIDAIFDKGYSTKGSNRGVGL 503
|
330 340 350
....*....|....*....|....*....|....*...
gi 16130156 569 ALSQRIINAHQGDIRVASLPGYGATFTLILPINPQGNQ 606
Cdd:PRK11086 504 YLVKQSVENLGGSIAVESEPGVGTQFFVQIPWDGERSN 541
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
379-603 |
4.91e-19 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 90.05 E-value: 4.91e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 379 RMAQ--AERLATLGELMAGVAHEVRNPLTAIRGYVQILRQQTSDpiHQEYLSvvlKEIDSINKVIQQLLEFS---RPRHS 453
Cdd:PRK10604 200 QMADniNALIASKKQLIDGIAHELRTPLVRLRYRLEMSDNLSAA--ESQALN---RDIGQLEALIEELLTYArldRPQNE 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 454 -QWQQVSLNALVEETLVLVQTagVQARVDFISELDNELSPINADRELLKQVLLNILINAVQaiSARGKIRIQTWQySDSQ 532
Cdd:PRK10604 275 lHLSEPDLPAWLSTHLADIQA--VTPEKTVRLDTPHQGDYGALDMRLMERVLDNLLNNALR--YAHSRVRVSLLL-DGNQ 349
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16130156 533 QAISIEDNGCGIDLSLQKKIFDPFFTTKAS------GTGLGLALSQRIINAHQGDIRVASLPGYGATFTLILPINPQ 603
Cdd:PRK10604 350 ACLIVEDDGPGIPPEERERVFEPFVRLDPSrdratgGCGLGLAIVHSIALAMGGSVNCDESELGGARFSFSWPVWHN 426
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
496-599 |
6.19e-19 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 82.59 E-value: 6.19e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 496 DRELLKQVLLNILINAVQAISAR----GKIRIQTWQYSDSQQAISIEDNGCGIDLSLQKKIFDPFFTTKASGTGLGLALS 571
Cdd:cd16944 1 DTTQISQVLTNILKNAAEAIEGRpsdvGEVRIRVEADQDGRIVLIVCDNGKGFPREMRHRATEPYVTTRPKGTGLGLAIV 80
|
90 100
....*....|....*....|....*...
gi 16130156 572 QRIINAHQGDIRVASLPGYGATFTLILP 599
Cdd:cd16944 81 KKIMEEHGGRISLSNREAGGACIRIILP 108
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
370-602 |
1.48e-18 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 90.10 E-value: 1.48e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 370 LTARKETQRRMAQAERLATlgELMAGVAHEVRNPLTAIRGYVQILRQQTS--DPIHQEYLSVVLKEIDSINKVIQQLLEF 447
Cdd:PRK10490 647 LTASEEQARLASEREQLRN--ALLAALSHDLRTPLTVLFGQAEILTLDLAseGSPHARQASEIRQQVLNTTRLVNNLLDM 724
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 448 SRPR------HSQWQqvSLNALVEETLVLVQTAGVQARVDFisELDNELSPINADRELLKQVLLNILINAVQAISARGKI 521
Cdd:PRK10490 725 ARIQsggfnlRKEWL--TLEEVVGSALQMLEPGLSGHPINL--SLPEPLTLIHVDGPLFERVLINLLENAVKYAGAQAEI 800
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 522 RIQTWqYSDSQQAISIEDNGCGIDLSLQKKIFDPFFT-TKAS---GTGLGLALSQRIINAHQGDIRVASLPGYGATFTLI 597
Cdd:PRK10490 801 GIDAH-VEGERLQLDVWDNGPGIPPGQEQLIFDKFARgNKESaipGVGLGLAICRAIVEVHGGTIWAENRPEGGACFRVT 879
|
....*
gi 16130156 598 LPINP 602
Cdd:PRK10490 880 LPLET 884
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
254-447 |
4.92e-18 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 84.31 E-value: 4.92e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 254 AQALRETRTLNDLIIENAADGVIAIDRQGDVTTMNPAAEVITGYQRHELVGQPYSMLF--DNTQFYSPVLDTLEHGTEHV 331
Cdd:COG2202 3 EEALEESERRLRALVESSPDAIIITDLDGRILYVNPAFERLTGYSAEELLGKTLRDLLppEDDDEFLELLRAALAGGGVW 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 332 ALEISFPGRD-RTIELSVTTSRIHNTHGEMIGALVIFSDLTARKETQRRMAQAE-RLATLGELMA---------GVAHEV 400
Cdd:COG2202 83 RGELRNRRKDgSLFWVELSISPVRDEDGEITGFVGIARDITERKRAEEALRESEeRLRLLVENAPdgifvldldGRILYV 162
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 16130156 401 RNPLTAIRGY--VQILRQQTSDPIHQEYLSVVLKEIDSINKVIQQLLEF 447
Cdd:COG2202 163 NPAAEELLGYspEELLGKSLLDLLHPEDRERLLELLRRLLEGGRESYEL 211
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
370-599 |
5.42e-17 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 83.52 E-value: 5.42e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 370 LTARKETQRRMAQAERLatlgELMAGVAHEVRNPLTAIRGYVQILRQQTSD-PIHQEYLSVVLKEIDSINKVIQQLLEFS 448
Cdd:PRK11006 189 MVARDVTQMHQLEGARR----NFFANVSHELRTPLTVLQGYLEMMQDQPLEgALREKALHTMREQTQRMEGLVKQLLTLS 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 449 R----PRHSQWQQVSLNALVEetlVLVQTAGV--QARVDFISELDNELSpINADRELLKQVLLNILINAVQAISARGKIR 522
Cdd:PRK11006 265 KieaaPTIDLNEKVDVPMMLR---VLEREAQTlsQGKHTITFEVDNSLK-VFGNEDQLRSAISNLVYNAVNHTPEGTHIT 340
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 523 IqTWQYSDSQQAISIEDNGCGIDLSLQKKIFDPFF-TTKA-----SGTGLGLALSQRIINAHQGDIRVASLPGYGATFTL 596
Cdd:PRK11006 341 V-RWQRVPQGAEFSVEDNGPGIAPEHIPRLTERFYrVDKArsrqtGGSGLGLAIVKHALSHHDSRLEIESEVGKGTRFSF 419
|
...
gi 16130156 597 ILP 599
Cdd:PRK11006 420 VLP 422
|
|
| RocR |
COG3829 |
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis ... |
254-385 |
6.07e-17 |
|
RocR-type transcriptional regulator, contains PAS, AAA-type ATPase, and DNA-binding Fis domains [Transcription, Signal transduction mechanisms];
Pssm-ID: 443041 [Multi-domain] Cd Length: 448 Bit Score: 83.67 E-value: 6.07e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 254 AQALRETRTLNDLIIENAADGVIAIDRQGDVTTMNPAAEVITGYQRHELVGQPYSMLFDNtqfySPVLDTLEHGTEHVAL 333
Cdd:COG3829 3 ELELKELEEELEAILDSLDDGIIVVDADGRITYVNRAAERILGLPREEVIGKNVTELIPN----SPLLEVLKTGKPVTGV 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 16130156 334 EISFPGRDRTIElsVTTSRIHNtHGEMIGALVIFSDLTARKETQRRMAQAER 385
Cdd:COG3829 79 IQKTGGKGKTVI--VTAIPIFE-DGEVIGAVETFRDITELKRLERKLREEEL 127
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
500-599 |
9.38e-16 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 73.57 E-value: 9.38e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 500 LKQVLLNILINAVQAISARGKIRIQT----------WQYSDSQQA----ISIEDNGCGIDLSLQKKIFDPFFTTK--ASG 563
Cdd:cd16919 1 LELAILNLAVNARDAMPEGGRLTIETsnqrvdadyaLNYRDLIPGnyvcLEVSDTGSGMPAEVLRRAFEPFFTTKevGKG 80
|
90 100 110
....*....|....*....|....*....|....*.
gi 16130156 564 TGLGLALSQRIINAHQGDIRVASLPGYGATFTLILP 599
Cdd:cd16919 81 TGLGLSMVYGFVKQSGGHLRIYSEPGVGTTVRIYLP 116
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
369-600 |
1.27e-15 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 80.93 E-value: 1.27e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 369 DLTARKETQRRMAQAERLATlGELMAGVAHEVRNPLTAIRGYVQILRQQ-TSDPIHQEYLSVVLKEIDSINKVIQQLLEF 447
Cdd:PRK09959 693 DLIHALEVERNKAINATVAK-SQFLATMSHEIRTPISSIMGFLELLSGSgLSKEQRVEAISLAYATGQSLLGLIGEILDV 771
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 448 SRPRHSQWQ----QVSLNALVEETlvlVQTAGVQARVDFISELDNELSP----INADRELLKQVLLNILINAVQaISARG 519
Cdd:PRK09959 772 DKIESGNYQlqpqWVDIPTLVQNT---CHSFGAIAASKSIALSCSSTFPdhylVKIDPQAFKQVLSNLLSNALK-FTTEG 847
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 520 KIRIQT-WQYSDSQQAI---SIEDNGCGIDLSLQKKIFDPFFTTKA----SGTGLGLALSQRIINAHQGDIRVASLPGYG 591
Cdd:PRK09959 848 AVKITTsLGHIDDNHAVikmTIMDSGSGLSQEEQQQLFKRYSQTSAgrqqTGSGLGLMICKELIKNMQGDLSLESHPGIG 927
|
....*....
gi 16130156 592 ATFTLILPI 600
Cdd:PRK09959 928 TTFTITIPV 936
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
496-599 |
1.42e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 72.88 E-value: 1.42e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 496 DRELLKQVLLNILINAVQAISARGKIRIQTWQYSDSQQaISIEDNGCGIDLSLQKKIFDPFFTTKAS------GTGLGLA 569
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVR-LDVEDSAPGVSDDQLARLFERFYRVESSrnrasgGSGLGLA 79
|
90 100 110
....*....|....*....|....*....|
gi 16130156 570 LSQRIINAHQGDIRVASLPGYGATFTLILP 599
Cdd:cd16946 80 ICHNIALAHGGTISAEHSPLGGLRLVLTLP 109
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
389-452 |
2.09e-15 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 70.70 E-value: 2.09e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16130156 389 LGELMAGVAHEVRNPLTAIRGYVQILRQQTSDPIHQEYLSVVLKEIDSINKVIQQLLEFSRPRH 452
Cdd:pfam00512 2 KSEFLANLSHELRTPLTAIRGYLELLRDEKLDEEQREYLETILRSAERLLRLINDLLDLSRIEA 65
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
389-452 |
2.95e-15 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 70.29 E-value: 2.95e-15
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16130156 389 LGELMAGVAHEVRNPLTAIRGYVQILRQQTSDPIHQEYLSVVLKEIDSINKVIQQLLEFSRPRH 452
Cdd:smart00388 2 KREFLANLSHELRTPLTAIRGYLELLLDTELSEEQREYLETILREAERLLRLINDLLDLSRIEA 65
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
500-599 |
3.49e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 71.59 E-value: 3.49e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 500 LKQVLLNILINAVQAISARGKIRIQTWqYSD--SQQAISIEDNGCGIDLSLQKKIFDPF----FTTKASGTGLGLALSQR 573
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPPRIEVG-AEDvgEEWTFYVRDNGIGIDPEYAEKVFGIFqrlhSREEYEGTGVGLAIVRK 79
|
90 100
....*....|....*....|....*.
gi 16130156 574 IINAHQGDIRVASLPGYGATFTLILP 599
Cdd:cd16921 80 IIERHGGRIWLESEPGEGTTFYFTLP 105
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
363-600 |
5.69e-15 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 78.48 E-value: 5.69e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 363 ALVIFSDLTAR---KETQRRMAQAERLATLGELM--AGVAHEVRNPLTAIRGYVQILRQQTsdpIHQEYLSVVLKEIDS- 436
Cdd:PRK10841 416 AICVLVDVSARvkmEESLQEMAQAAEQASQSKSMflATVSHELRTPLYGIIGNLDLLQTKE---LPKGVDRLVTAMNNSs 492
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 437 --INKVIQQLLEFSR---------PRHSQWQQVsLNALVEETLVLVqtagVQARVD---FIsELDNELSpINADRELLKQ 502
Cdd:PRK10841 493 slLLKIISDILDFSKieseqlkiePREFSPREV-INHITANYLPLV----VKKRLGlycFI-EPDVPVA-LNGDPMRLQQ 565
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 503 VLLNILINAVQaISARGKIRIQTwQYSDSQQAISIEDNGCGIDLSLQKKIFDPFFTTKAS------GTGLGLALSQRIIN 576
Cdd:PRK10841 566 VISNLLSNAIK-FTDTGCIVLHV-RVDGDYLSFRVRDTGVGIPAKEVVRLFDPFFQVGTGvqrnfqGTGLGLAICEKLIN 643
|
250 260
....*....|....*....|....
gi 16130156 577 AHQGDIRVASLPGYGATFTLILPI 600
Cdd:PRK10841 644 MMDGDISVDSEPGMGSQFTIRIPL 667
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
392-603 |
6.14e-15 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 77.37 E-value: 6.14e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 392 LMAGVAHEVRNPLTAIRGYVQIL----RQQTSDPIHQeylsvVLKEIDSINKVIQQL--LEFSRPRHSQWQQVSLNALVe 465
Cdd:PRK10549 243 FMADISHELRTPLAVLRGELEAIqdgvRKFTPESVAS-----LQAEVGTLTKLVDDLhqLSLSDEGALAYRKTPVDLVP- 316
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 466 etlvLVQTAGVQARVDFIS---ELDNEL---SPINADRELLKQVLLNILINAVQAISARGKIRIQTWQySDSQQAISIED 539
Cdd:PRK10549 317 ----LLEVAGGAFRERFASrglTLQLSLpdsATVFGDPDRLMQLFNNLLENSLRYTDSGGSLHISAEQ-RDKTLRLTFAD 391
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 540 NGCGIDLSLQKKIFDPFFTTKAS------GTGLGLALSQRIINAHQGDIRVASLPGYGATFTLILPINPQ 603
Cdd:PRK10549 392 SAPGVSDEQLQKLFERFYRTEGSrnrasgGSGLGLAICLNIVEAHNGRIIAAHSPFGGVSITVELPLERD 461
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
482-598 |
8.32e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 71.01 E-value: 8.32e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 482 FISELDNELSPI--NADRELLKQVLLNILINAVQAISArGKIRIQTWQYSDSQQAISIEDNGCGIDLSLQKKIFDPFFTT 559
Cdd:cd16947 1 FQVEINIPDRPIyaNANTEALQRILKNLISNAIKYGSD-GKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTL 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 16130156 560 KAS------GTGLGLALSQRIINAHQGDIRVASLPGYGATFTLIL 598
Cdd:cd16947 80 EDSrnsakqGNGLGLTITKRLAESMGGSIYVNSKPYEKTVFTVTL 124
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
386-449 |
2.47e-14 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 67.62 E-value: 2.47e-14
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16130156 386 LATLGELMAGVAHEVRNPLTAIRGYVQIL-RQQTSDPIHQEYLSVVLKEIDSINKVIQQLLEFSR 449
Cdd:cd00082 1 LQAKGEFLANVSHELRTPLTAIRGALELLeEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
382-580 |
5.77e-14 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 73.46 E-value: 5.77e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 382 QAERLATlgelmAGVAHEVRNPLTAIRGYVQILRQQtsdpiHQEYLSVVLKEIDSINKVIQQLLEFSRPRHS----QWQQ 457
Cdd:PRK10755 135 DQERLFT-----ADVAHELRTPLAGIRLHLELLEKQ-----HHIDVAPLIARLDQMMHTVEQLLQLARAGQSfssgHYQT 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 458 VSLN-----ALVEETLVLVQTAGVQARVdfisELDNELSPINADRELLKQVLLNILINAVQAISARGKIRIqTWQYSDSQ 532
Cdd:PRK10755 205 VKLLedvilPSQDELSEMLEQRQQTLLL----PESAADITVQGDATLLRLLLRNLVENAHRYSPEGSTITI-KLSQEDGG 279
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 16130156 533 QAISIEDNGCGIDLSLQKKIFDPF--FTTKASGTGLGLALSQRIINAHQG 580
Cdd:PRK10755 280 AVLAVEDEGPGIDESKCGELSKAFvrMDSRYGGIGLGLSIVSRITQLHHG 329
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
506-599 |
8.25e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 67.70 E-value: 8.25e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 506 NILINAVQAISA--RGKIRIQTWQYSDSQQA-ISIEDNGCGIDLSLQKKIFDPFFTTKASGT-GLGLALSQRIINAHQGD 581
Cdd:cd16915 7 NLIDNALDALAAtgAPNKQVEVFLRDEGDDLvIEVRDTGPGIAPELRDKVFERGVSTKGQGErGIGLALVRQSVERLGGS 86
|
90
....*....|....*...
gi 16130156 582 IRVASLPGYGATFTLILP 599
Cdd:cd16915 87 ITVESEPGGGTTFSIRIP 104
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
500-599 |
1.10e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 67.35 E-value: 1.10e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 500 LKQVLLNILINAVQaiSARGKIRIqTWQYSDSQQAISIEDNGCGIDLSLQKKIFDPFF------TTKASGTGLGLALSQR 573
Cdd:cd16949 1 LARALENVLRNALR--YSPSKILL-DISQDGDQWTITITDDGPGVPEDQLEQIFLPFYrvdsarDRESGGTGLGLAIAER 77
|
90 100
....*....|....*....|....*.
gi 16130156 574 IINAHQGDIRVASLPGYGATFTLILP 599
Cdd:cd16949 78 AIEQHGGKIKASNRKPGGLRVRIWLP 103
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
496-599 |
2.97e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 66.15 E-value: 2.97e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 496 DRELLKQVLLNILINAVQAISARGKIRIQTWQySDSQQAISIEDNGCGIDLSLQKKIFDPFFT------TKASgTGLGLA 569
Cdd:cd16948 2 DAKWLSFIIGQIVSNALKYSKQGGKIEIYSET-NEQGVVLSIKDFGIGIPEEDLPRVFDKGFTgengrnFQES-TGMGLY 79
|
90 100 110
....*....|....*....|....*....|
gi 16130156 570 LSQRIINAHQGDIRVASLPGYGATFTLILP 599
Cdd:cd16948 80 LVKKLCDKLGHKIDVESEVGEGTTFTITFP 109
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
496-599 |
7.70e-13 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 65.21 E-value: 7.70e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 496 DRELLKQVLLNILINAVQAISARGKIRIQTWQYSDSQQAISIEDNGCGIDLSLQKKIFDPF------FTTKASGTGLGLA 569
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRLNRFLLTVSDSGPGIPPNLREEIFERFrqgdgsSTRAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|
gi 16130156 570 LSQRIINAHQGDIRVASLPGYGATFTLILP 599
Cdd:cd16925 81 IVKEFVELHGGTVTVSDAPGGGALFQVELP 110
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
500-599 |
7.83e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 64.78 E-value: 7.83e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 500 LKQVLLNILINAVQaiSARGKIRIQTwQYSDSQQAISIEDNGCGIDLSLQKKIFDPFFTTKA----SGTGLGLALSQRII 575
Cdd:cd16950 1 LKRVLSNLVDNALR--YGGGWVEVSS-DGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNargtSGTGLGLAIVQRIS 77
|
90 100
....*....|....*....|....
gi 16130156 576 NAHQGDIRVASLPGYGATFTLILP 599
Cdd:cd16950 78 DAHGGSLTLANRAGGGLCARIELP 101
|
|
| PAS |
COG2202 |
PAS domain [Signal transduction mechanisms]; |
255-380 |
9.30e-13 |
|
PAS domain [Signal transduction mechanisms];
Pssm-ID: 441804 [Multi-domain] Cd Length: 258 Bit Score: 68.51 E-value: 9.30e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 255 QALRETRTLNDLIIENAADGVIAIDRQGDVTTMNPAAEVITGYQRHELVGQPYSMLF---DNTQFYSPVLDTLEHGTEHV 331
Cdd:COG2202 130 EALRESEERLRLLVENAPDGIFVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLhpeDRERLLELLRRLLEGGRESY 209
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 16130156 332 ALEISFPGRDRTIELSVTTSRIHNTHGEMIGALVIFSDLTARKETQRRM 380
Cdd:COG2202 210 ELELRLKDGDGRWVWVEASAVPLRDGGEVIGVLGIVRDITERKRAEEAL 258
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
500-599 |
3.57e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 62.99 E-value: 3.57e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 500 LKQVLLNILINAVQAISARGKIRIQtWQYSDSQQAISIEDNGCGIDLSLQKKIFDPFF------TTKASGTGLGLALSQR 573
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVR-WSQEESGARLSVEDTGPGIPPEHIPRLTERFYrvdierCRNTGGTGLGLAIVKH 79
|
90 100
....*....|....*....|....*.
gi 16130156 574 IINAHQGDIRVASLPGYGATFTLILP 599
Cdd:cd16952 80 VMSRHDARLLIASELGKGSRFTCLFP 105
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
496-596 |
4.24e-12 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 62.86 E-value: 4.24e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 496 DRELLKQVLLNILINAVQAISARGKIRIQTwQYSDSQQAISIEDNGCGIDLSLQKKIFDPFFT-----TKASGTGLGLAL 570
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQL-EADTEGIELLVFDEGSGIPDYALNRVFERFYSlprphSGQKSTGLGLAF 79
|
90 100
....*....|....*....|....*..
gi 16130156 571 SQRIINAHQGDIRVASLP-GYGATFTL 596
Cdd:cd16945 80 VQEVAQLHGGRITLRNRPdGVLAFLTL 106
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
392-604 |
8.61e-12 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 67.65 E-value: 8.61e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 392 LMAGVAHEVRNPLTAIRGYVQILRQQtsdpiHQEY--LSVVLKEIDSINKVIQQLLEFSRPRHSQWQQ---VSLNALVEE 466
Cdd:PRK09470 246 LLSDISHELRTPLTRLQLATALLRRR-----QGESkeLERIETEAQRLDSMINDLLVLSRNQQKNHLEretFKANSLWSE 320
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 467 TLVLVQTAGVQARVDFISELDNELSPINADRELLKQVLLNILINAVQaisaRGKIRIQTWQYSDSQQ-AISIEDNGCGID 545
Cdd:PRK09470 321 VLEDAKFEAEQMGKSLTVSAPPGPWPINGNPNALASALENIVRNALR----YSHTKIEVAFSVDKDGlTITVDDDGPGVP 396
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16130156 546 LSLQKKIFDPFFTT------KASGTGLGLALSQRIINAHQGDIRVASLPGYGATFTLILPINPQG 604
Cdd:PRK09470 397 EEEREQIFRPFYRVdeardrESGGTGLGLAIVENAIQQHRGWVKAEDSPLGGLRLTIWLPLYKRS 461
|
|
| sensory_box |
TIGR00229 |
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ... |
266-379 |
1.08e-11 |
|
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]
Pssm-ID: 272971 [Multi-domain] Cd Length: 124 Bit Score: 62.31 E-value: 1.08e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 266 LIIENAADGVIAIDRQGDVTTMNPAAEVITGYQRHELVGQPYSMLF--DNTQFYSPVLDTLEHGTEH-VALEISFPGRD- 341
Cdd:TIGR00229 7 AIFESSPDAIIVIDLEGNILYVNPAFEEIFGYSAEELIGRNVLELIpeEDREEVRERIERRLEGEPEpVSEERRVRRKDg 86
|
90 100 110
....*....|....*....|....*....|....*...
gi 16130156 342 RTIELSVTTSRIHnTHGEMIGALVIFSDLTARKETQRR 379
Cdd:TIGR00229 87 SEIWVEVSVSPIR-TNGGELGVVGIVRDITERKEAEEA 123
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
271-370 |
3.23e-11 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 60.34 E-value: 3.23e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 271 AADGVIAIDRQGDVTTMNPAAEVITGYQRHELVGQPYSMLF---DNTQFYSPVLDTLEHGtEHVALEISFPGRD-RTIEL 346
Cdd:cd00130 1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIhpeDREELRERLENLLSGG-EPVTLEVRLRRKDgSVIWV 79
|
90 100
....*....|....*....|....
gi 16130156 347 SVTTSRIHNTHGEMIGALVIFSDL 370
Cdd:cd00130 80 LVSLTPIRDEGGEVIGLLGVVRDI 103
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
496-591 |
3.31e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 60.50 E-value: 3.31e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 496 DRELLKQVLLNILINAVQAISARGKIRIQtwQYSDSQQAISIEDNGCGIDLSLQKKIFDPFF---TTKASGTGLGLALSQ 572
Cdd:cd16940 10 DALLLFLLLRNLVDNAVRYSPQGSRVEIK--LSADDGAVIRVEDNGPGIDEEELEALFERFYrsdGQNYGGSGLGLSIVK 87
|
90
....*....|....*....
gi 16130156 573 RIINAHQGDIRVASLPGYG 591
Cdd:cd16940 88 RIVELHGGQIFLGNAQGGG 106
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
500-599 |
4.64e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 59.75 E-value: 4.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 500 LKQVLLNILINAVQaiSARGKIRIqTWQYSDSQQAISIEDNGCGIDLSLQKKIFDPFF------TTKASGTGLGLALSQR 573
Cdd:cd16939 1 MARALDNLLRNALR--YAHRTVRI-ALLVSGGRLTLIVEDDGPGIPAAARERVFEPFVrldpsrDRATGGFGLGLAIVHR 77
|
90 100
....*....|....*....|....*.
gi 16130156 574 IINAHQGDIRVASLPGYGATFTLILP 599
Cdd:cd16939 78 VALWHGGHVECDDSELGGACFRLTWP 103
|
|
| PAS_9 |
pfam13426 |
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ... |
281-372 |
5.08e-11 |
|
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463873 [Multi-domain] Cd Length: 93 Bit Score: 59.40 E-value: 5.08e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 281 QGDVTTMNPAAEVITGYQRHELVGQPYSMLFDNTQFYSPVLDTLEHGTEHVALEISFPGRD-RTIELSVTTSRIHNTHGE 359
Cdd:pfam13426 1 DGRIIYVNDAALRLLGYTREELLGKSITDLFAEPEDSERLREALREGKAVREFEVVLYRKDgEPFPVLVSLAPIRDDGGE 80
|
90
....*....|...
gi 16130156 360 MIGALVIFSDLTA 372
Cdd:pfam13426 81 LVGIIAILRDITE 93
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
391-601 |
1.55e-10 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 64.10 E-value: 1.55e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 391 ELMAGVAHEVRNPLTAIRGYVqilRQQTSDPIH---QEYLSVVLKEIDSINKVIQQLLEFSR-----------Prhsqwq 456
Cdd:PRK11107 295 EFLANMSHELRTPLNGVIGFT---RQTLKTPLTptqRDYLQTIERSANNLLAIINDILDFSKleagklvleniP------ 365
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 457 qVSLNALVEETLVLVQTAgvqARvdfisELDNELSpINADREL----------LKQVLLNILINAVQaISARGKIRIQTW 526
Cdd:PRK11107 366 -FSLRETLDEVVTLLAHS---AH-----EKGLELT-LNIDPDVpdnvigdplrLQQIITNLVGNAIK-FTESGNIDILVE 434
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 527 QYSDSQQAISIE----DNGCGIDLSLQKKIFDPFFTTKAS------GTGLGLALSQRIINAHQGDIRVASLPGYGATFTL 596
Cdd:PRK11107 435 LRALSNTKVQLEvqirDTGIGISERQQSQLFQAFRQADASisrrhgGTGLGLVITQKLVNEMGGDISFHSQPNRGSTFWF 514
|
....*
gi 16130156 597 ILPIN 601
Cdd:PRK11107 515 HLPLD 519
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
397-591 |
1.07e-09 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 60.82 E-value: 1.07e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 397 AHEVRNPLTAIRgyVQILRQQTS--DPIHQEY-LSVVLKEIDSINKVIQQLLEFSR----PRHSQWQQVSLNALVEETLV 469
Cdd:PRK10337 245 AHELRSPLAALK--VQTEVAQLSddDPQARKKaLLQLHAGIDRATRLVDQLLTLSRldslDNLQDVAEIPLEDLLQSAVM 322
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 470 ----LVQTAGVQARVDFiseldNELSPINADRELLKQVLL-NILINAVQaISARGKIRIQTWqysdSQQAISIEDNGCGI 544
Cdd:PRK10337 323 diyhTAQQAGIDVRLTL-----NAHPVIRTGQPLLLSLLVrNLLDNAIR-YSPQGSVVDVTL----NARNFTVRDNGPGV 392
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 16130156 545 DLSLQKKIFDPFFT---TKASGTGLGLALSQRIINAHQGDIRVASLPGYG 591
Cdd:PRK10337 393 TPEALARIGERFYRppgQEATGSGLGLSIVRRIAKLHGMNVSFGNAPEGG 442
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
152-600 |
2.01e-09 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 60.30 E-value: 2.01e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 152 RGDILNSMLPIERNGEILGYIWANELTEDIRRQAWKMDVRIIIVLTAGLLISLLLIVLFSRRLSANIDIITDGLSTLAQN 231
Cdd:COG3920 60 AAALAAALAVALAAAVGAAAALLALLVLLLLLLLAAAALALALLLAALAGLLLLAALLLLRLVALLAALALLALLLLLLL 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 232 IPTRLPQLPGEMGQISQSVNNLAQALRETRTLNDLIIENAADGVIAIDRQGDVTTMNPAAEVITGYQRHELVGQPYSMLF 311
Cdd:COG3920 140 LLAILALAELAVALAELAAALLLLAEELAALRLAAAALLLLLAALLDLGLALAALAAAALLALLLALELLLALLLLLLLL 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 312 DNTQFYSPVLDTLEHGTEHVALEISFPGRDRTIELSVTTSRIHNTHGEMIGALVIFSDLTARKETQRRMAQAERLATLge 391
Cdd:COG3920 220 LALLLVLLAALLRLRAAVLEELERRRRARGLGRLLLLLLLLLLLLRALLLLAAGIRLVITERKRAEEELEASLEEKEL-- 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 392 LMAGVAHEVRNPLTAIRGYVQILRQQTSDPIHQEYLSVVLKEIDSINKVIQQLLefsrpRHSQWQQVSLNALVEETLVLV 471
Cdd:COG3920 298 LLRELHHRVKNNLQVVSSLLRLQARRADDPEAREALEESQNRIQALALVHELLY-----QSEDWEGVDLRDYLRELLEPL 372
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 472 QTAGVQARVDFisELDNELSPINADR---------ELlkqvllniLINAVQ--AISAR-GKIRIqTWQYSDSQQAISIED 539
Cdd:COG3920 373 RDSYGGRGIRI--ELDGPDVELPADAavplglilnEL--------VTNALKhaFLSGEgGRIRV-SWRREDGRLRLTVSD 441
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16130156 540 NGCGIdlslqkkifdPFFTTKASGTGLGLALSQRIINAHQGDIRVASlpGYGATFTLILPI 600
Cdd:COG3920 442 NGVGL----------PEDVDPPARKGLGLRLIRALVRQLGGTLELDR--PEGTRVRITFPL 490
|
|
| PAS_4 |
pfam08448 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
269-375 |
2.97e-09 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain is associated to signalling systems and works as a signal sensor domain. It recognizes differently substituted aromatic hydrocarbons, oxygen, different dodecanoic acids, autoinducers, 3,5-dimethyl-pyrazin-2-ol and N-alanyl-aminoacetone (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 312075 [Multi-domain] Cd Length: 110 Bit Score: 54.73 E-value: 2.97e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 269 ENAADGVIAIDRQGDVTTMNPAAEVITGYQRHELVGQPYSMLFDNTQF------YSPVLDTLEhgTEHVALEISFPGRDR 342
Cdd:pfam08448 2 DSLPDALAVLDPDGRVRYANAAAAELFGLPPEELLGKTLAELLPPEDAarleraLRRALEGEE--PIDFLEELLLNGEER 79
|
90 100 110
....*....|....*....|....*....|...
gi 16130156 343 TIELSVTtsRIHNTHGEMIGALVIFSDLTARKE 375
Cdd:pfam08448 80 HYELRLT--PLRDPDGEVIGVLVISRDITERRR 110
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
263-311 |
2.43e-08 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 50.86 E-value: 2.43e-08
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 16130156 263 LNDLIIENAADGVIAIDRQGDVTTMNPAAEVITGYQRHELVGQPYSMLF 311
Cdd:smart00091 2 RLRAILESLPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELI 50
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
496-596 |
3.25e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 51.69 E-value: 3.25e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 496 DRELLKQVLLNILINAVQAISARGKIRIQTWqysDSQQAIS--IEDNGCGIDLSLQKKIFDPFFTTKASGT-----GLGL 568
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIY---DEEEYLYfeIWDNGHGFSEQDLKKALELFYRDDTSRRsgghyGMGL 77
|
90 100
....*....|....*....|....*...
gi 16130156 569 ALSQRIINAHQGDIRVASLPGYGATFTL 596
Cdd:cd16975 78 YIAKNLVEKHGGSLIIENSQKGGAEVTV 105
|
|
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
394-599 |
4.65e-08 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 55.93 E-value: 4.65e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 394 AGVAHEVRNPLTAIRGYVQI-LRQQTSDPIHQEYLSVVLKEIDSINKVIQQLLEFSRPRHSQW--QQVSLN--------- 461
Cdd:PRK09835 267 ADIAHEIRTPITNLITQTEIaLSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLipEKKMLDladevgkvf 346
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 462 ----ALVEETLVLVQTAGVQARVDfiseldnelspinADRELLKQVLLNILINAVQAISARGKIRIQTwQYSDSQQAISI 537
Cdd:PRK09835 347 dffeAWAEERGVELRFVGDPCQVA-------------GDPLMLRRAISNLLSNALRYTPAGEAITVRC-QEVDHQVQLVV 412
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16130156 538 EDNGCGIDLSLQKKIFDPFFTT------KASGTGLGLALSQRIINAHQGDIRVASLPgYGATFTLILP 599
Cdd:PRK09835 413 ENPGTPIAPEHLPRLFDRFYRVdpsrqrKGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVISLP 479
|
|
| PRK09776 |
PRK09776 |
putative diguanylate cyclase; Provisional |
249-381 |
7.31e-08 |
|
putative diguanylate cyclase; Provisional
Pssm-ID: 182070 [Multi-domain] Cd Length: 1092 Bit Score: 55.83 E-value: 7.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 249 SVNNLAQALRETRTLNDLIIENAADGVIAIDRQGDVTTMNPAAEVITGYQRHELVGQPYSMLFDNT-QFYSPVLDTLEHG 327
Cdd:PRK09776 523 EVRQLNEALFQEKERLHITLDSIGEAVVCTDMAMKVTFMNPVAEKMTGWTQEEALGVPLLTVLHITfGDNGPLMENIYSC 602
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16130156 328 TEHVA---LE-----ISFPGRDRTIELSVTTSRIHNthGEMIGALVIFSDLTARKETQRRMA 381
Cdd:PRK09776 603 LTSRSaayLEqdvvlHCRSGGSYDVHYSITPLSTLD--GENIGSVLVIQDVTESRKMLRQLS 662
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
500-599 |
9.70e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 50.65 E-value: 9.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 500 LKQVLLNILINAVQ-AISARGKIRIQTWQYSDSQQaISIEDNGCGIDLSLQKKIFDPFFTTKASG------TGLGLALSQ 572
Cdd:cd16953 1 LGQVLRNLIGNAISfSPPDTGRITVSAMPTGKMVT-ISVEDEGPGIPQEKLESIFDRFYTERPANeafgqhSGLGLSISR 79
|
90 100 110
....*....|....*....|....*....|..
gi 16130156 573 RIINAHqGDIRVASL---PGY--GATFTLILP 599
Cdd:cd16953 80 QIIEAH-GGISVAENhnqPGQviGARFTVQLP 110
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
479-603 |
1.17e-07 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 54.64 E-value: 1.17e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 479 RVDFISELDNELspinADRELLKQVLLNILINAVQA----ISARGKIRIQTWQYSDSQQaISIEDNGCGIDLSLQKKIFD 554
Cdd:COG2972 320 RLEVEIEIDEEL----LDLLIPKLILQPLVENAIEHgiepKEGGGTIRISIRKEGDRLV-ITVEDNGVGMPEEKLEKLLE 394
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 16130156 555 PfFTTKASGTGLGLALSQRIINAHQGD---IRVASLPGYGATFTLILPINPQ 603
Cdd:COG2972 395 E-LSSKGEGRGIGLRNVRERLKLYYGEeygLEIESEPGEGTTVTIRIPLEEE 445
|
|
| dpiB |
PRK15053 |
sensor histidine kinase DpiB; Provisional |
253-599 |
7.65e-07 |
|
sensor histidine kinase DpiB; Provisional
Pssm-ID: 185013 [Multi-domain] Cd Length: 545 Bit Score: 52.14 E-value: 7.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 253 LAQALRETRTLNDLIIEnaadGVIAIDRQGDVTTMNPAAEVITGYQR--HELVGQPYSMLFDNTQFYspvldTLEHGTEH 330
Cdd:PRK15053 217 IARVVRQQEALFSSVYE----GLIAVDPHGYITAINRNARKMLGLSSpgRQWLGKPIAEVVRPADFF-----TEQIDEKR 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 331 VALEISFPGrdrtieLSVTTSRIHNTHG-EMIGALVIFSdltARKETQRRMAQAERLATLGELMAGVAHEVRNPLTAIRG 409
Cdd:PRK15053 288 QDVVANFNG------LSVIANREAIRSGdDLLGAIISFR---SKDEISTLNAQLTQIKQYVESLRTLRHEHLNWMSTLNG 358
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 410 YVQIlrqqtsdpihQEYlSVVLKEIDSINKVIQQLLEFSRPRHSQWQQVSL-----NALVEETLVLVQTAGVQarvdfIS 484
Cdd:PRK15053 359 LLQM----------KEY-DRVLEMVQGESQAQQQLIDSLREAFADRQVAGLlfgkvQRARELGLKMVIVPGSQ-----LS 422
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 485 ELdnelsPINADRELLKQVLLNILINAVQAI--SARGKIRIQTWqYSDSQQAISIE--DNGCGIDLSLQKKIFDPFFTTK 560
Cdd:PRK15053 423 QL-----PPGLDSTEFAAIVGNLLDNAFEASlrSDEGNKIVELF-LSDEGDDVVIEvaDQGCGVPESLRDKIFEQGVSTR 496
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 16130156 561 ASGT---GLGLALSQRIINAHQGDIRVASLPGYGATFTLILP 599
Cdd:PRK15053 497 ADEPgehGIGLYLIASYVTRCGGVITLEDNDPCGTLFSIFIP 538
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
479-598 |
2.43e-06 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 47.24 E-value: 2.43e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 479 RVDFISELDNELSpINADRELLKQVLLNILINAVQAisARGKIRIQTWQySDSQQAISIEDNGCGIDLSLQKKIFD--PF 556
Cdd:cd16954 18 GVSISLDISPELR-FPGERNDLMELLGNLLDNACKW--CLEFVEVTARQ-TDGGLHLIVDDDGPGVPESQRSKIFQrgQR 93
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 16130156 557 FTTKASGTGLGLALSQRIINAHQGDIRVASLPGYGATFTLIL 598
Cdd:cd16954 94 LDEQRPGQGLGLAIAKEIVEQYGGELSLSDSPLGGARFEVVF 135
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
360-602 |
2.83e-06 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 48.85 E-value: 2.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 360 MIGALVIFSDLTARKETQRRMAQAERLATLGELMA------------GVAHEvrnpLTAIRGYVQILRQQTS--DPIHQE 425
Cdd:COG4585 17 LLGLLLALVLLRARRAERAAELERELAARAEEAREeerrriarelhdGVGQS----LSAIKLQLEAARRLLDadPEAARE 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 426 YLSVVLKEIDSINKVIQQLLefSRPRHSQWQQVSLNALVEEtlvLVQTAGVQARVDFISELDNELSPINADREL-LKQVL 504
Cdd:COG4585 93 ELEEIRELAREALAELRRLV--RGLRPPALDDLGLAAALEE---LAERLLRAAGIRVELDVDGDPDRLPPEVELaLYRIV 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 505 LNILINAV---QAisarGKIRIqTWQYSDSQQAISIEDNGCGIDlslqkkifdpffTTKASGTGLGLALSQRIINAHQGD 581
Cdd:COG4585 168 QEALTNALkhaGA----TRVTV-TLEVDDGELTLTVRDDGVGFD------------PEAAPGGGLGLRGMRERAEALGGT 230
|
250 260
....*....|....*....|.
gi 16130156 582 IRVASLPGYGATFTLILPINP 602
Cdd:COG4585 231 LTIGSAPGGGTRVRATLPLAA 251
|
|
| HATPase_CheA-like |
cd16916 |
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some ... |
489-599 |
5.07e-05 |
|
Histidine kinase-like ATPase domain of the chemotaxis protein histidine kinase CheA, and some hybrid sensor histidine kinases; This family includes the cytoplasmic histidine kinase (HK) CheA, a transmembrane receptor which, together with cytoplasmic adaptor protein (CheW), forms the lattice at the core of the chemosensory array that controls the cellular chemotaxis of motile bacteria and archaea. CheA forms a two-component signal transduction system (TCS) with the response regulator CheY. Proteins having this CheA-like HATPase domain generally also have a histidine-phosphotransfer domain, a histidine kinase homodimeric domain, and a regulatory domain; some are hybrid sensor histidine kinases as they contain a REC signal receiver domain.
Pssm-ID: 340393 [Multi-domain] Cd Length: 178 Bit Score: 44.11 E-value: 5.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 489 ELSPINADRELLKQV-------LLNILINAV-QAI------SARGKIRIQTWQYSDSQQA----ISIEDNGCGIDLS--L 548
Cdd:cd16916 21 ELVVEGEDTELDKSVlekladpLTHLLRNAVdHGIeapeerLAAGKPPEGTITLRAEHQGnqvvIEVSDDGRGIDREkiR 100
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16130156 549 QKK----------------------IFDPFFTTKA-----SGTGLGLALSQRIINAHQGDIRVASLPGYGATFTLILP 599
Cdd:cd16916 101 EKAierglitadeaatlsddevlnlIFAPGFSTAEqvtdvSGRGVGMDVVKRSIESLGGTIEVESEPGQGTTFTIRLP 178
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
516-600 |
6.47e-05 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 45.94 E-value: 6.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 516 SARGKIRIQTWQySDSQQAISIEDNGCGIDLS-LQKK-----------------------IFDPFFTTKA-----SGTGL 566
Cdd:COG0643 306 PETGTITLSAYH-EGGRVVIEVSDDGRGLDLEkIRAKaiekglitaeeaaalsdeellelIFAPGFSTAEevtdlSGRGV 384
|
90 100 110
....*....|....*....|....*....|....
gi 16130156 567 GLALSQRIINAHQGDIRVASLPGYGATFTLILPI 600
Cdd:COG0643 385 GMDVVKTNIEALGGTIEIESEPGKGTTFTLRLPL 418
|
|
| PRK13560 |
PRK13560 |
hypothetical protein; Provisional |
257-383 |
1.08e-04 |
|
hypothetical protein; Provisional
Pssm-ID: 106506 [Multi-domain] Cd Length: 807 Bit Score: 45.43 E-value: 1.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 257 LRETRTLNDLIIENAADGVIAIDRQGDVTTM-NPAAEVITGYQRHELVGQP--------------------YSMLFDNTQ 315
Cdd:PRK13560 327 LLEKEDMLRAIIEAAPIAAIGLDADGNICFVnNNAAERMLGWSAAEVMGKPlpgmdpelneefwcgdfqewYPDGRPMAF 406
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16130156 316 FYSPVLDTLEHGTEHVALEISFPGRDRT-IELSVTTSRIHNTHGEMIGALVIFSDLTARKETQRRMAQA 383
Cdd:PRK13560 407 DACPMAKTIKGGKIFDGQEVLIEREDDGpADCSAYAEPLHDADGNIIGAIALLVDITERKQVEEQLLLA 475
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
502-592 |
4.18e-04 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 43.08 E-value: 4.18e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 502 QVLLNILINAVQ------AISARgkiriqtwqYSDSQQAISIEDNGCGIDLSLQKKIFD--PFFTTKASGTGLGLALSQR 573
Cdd:PRK10815 381 EVMGNVLDNACKyclefvEISAR---------QTDEHLHIVVEDDGPGIPESKRELIFDrgQRADTLRPGQGLGLSVARE 451
|
90
....*....|....*....
gi 16130156 574 IINAHQGDIRVASLPGYGA 592
Cdd:PRK10815 452 ITEQYEGKISAGDSPLGGA 470
|
|
| TyrR |
COG3283 |
Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid ... |
258-389 |
6.63e-04 |
|
Transcriptional regulator TyrR of aromatic amino acids metabolism [Transcription, Amino acid transport and metabolism];
Pssm-ID: 442513 [Multi-domain] Cd Length: 514 Bit Score: 42.48 E-value: 6.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 258 RETRTLNDLIiENAADGVIAIDRQGDVTTMNPAAEVITGYQRHELVGQPYSMLFDNTQFyspvLDTLEHGTEHV-ALEIS 336
Cdd:COG3283 77 REHLELDALL-EALPDPVFSIDLKGKIELANPAALSLLGLSEEELIGQPLSELLKGFNF----SRWLESNEPRPqSERVV 151
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 16130156 337 FPGRDRTIELSVTTSRIHNTHGEMIGALVIF-------SDLTARKETQ-----------RRM----AQAERLATL 389
Cdd:COG3283 152 INGQDYLADILPIYLPDEEGKSILAGAVVTLksaarlgEQLQALQVNDdsgfdhivassPKMrqviRQAKKMAML 226
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
500-599 |
9.64e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 38.91 E-value: 9.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 500 LKQVLLNILINAVQAISARGKIRIQTWQYSDSQQaISIEDNGCGI-DLSLQKkIFDPFF----TTKASGTGLGLALSQRI 574
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVN-IMFKNPSSHPlDFKLEK-LFERFYrgdnSRNTEGAGLGLSIAKAI 78
|
90 100
....*....|....*....|....*
gi 16130156 575 INAHQGDIRVASLpGYGATFTLILP 599
Cdd:cd16923 79 IELHGGSASAEYD-DNHDLFKVRLP 102
|
|
| PAS_8 |
pfam13188 |
PAS domain; PAS domains are involved in many signalling proteins where they are used as a ... |
267-317 |
1.00e-03 |
|
PAS domain; PAS domains are involved in many signalling proteins where they are used as a signal sensor domain. PAS domains appear in archaea, bacteria and eukaryotes. Several PAS-domain proteins are known to detect their signal by way of an associated cofactor. Heme, flavin, and a 4-hydroxycinnamyl chromophore are used in different proteins. This domain recognizes oxygen and CO (Matilla et al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 463802 [Multi-domain] Cd Length: 65 Bit Score: 37.91 E-value: 1.00e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 16130156 267 IIENAADGVIAIDRQGDVTTMNPAAEVITGYqrhELVGQPYSMLFDNTQFY 317
Cdd:pfam13188 6 LFESSPDGILVLDEGGRIIYVNPAALELLGY---ELLGELLGELLDLLDPL 53
|
|
| PRK11359 |
PRK11359 |
cyclic-di-GMP phosphodiesterase; Provisional |
274-310 |
1.25e-03 |
|
cyclic-di-GMP phosphodiesterase; Provisional
Pssm-ID: 183097 [Multi-domain] Cd Length: 799 Bit Score: 42.06 E-value: 1.25e-03
10 20 30
....*....|....*....|....*....|....*..
gi 16130156 274 GVIAIDRQGDVTTMNPAAEVITGYQRHELVGQPYSML 310
Cdd:PRK11359 24 GAVLINENDEVLFFNPAAEKLWGYKREEVIGNNIDML 60
|
|
| PRK10618 |
PRK10618 |
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional |
392-607 |
4.34e-03 |
|
phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional
Pssm-ID: 236726 [Multi-domain] Cd Length: 894 Bit Score: 40.30 E-value: 4.34e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 392 LMAGVAHEVRNPLTAIRGYVQILRQQTSDPIHQEYLSVVLKEIDSINKVIQ--QLLEfsRPRHSQWQQVS--------LN 461
Cdd:PRK10618 453 FLQNIGDELKQPLQSLAQLAAQLRQTSDEEQQQPELDQLAEQSDVLVRLVDniQLLN--MLETQDWKPEQelfslqdlID 530
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130156 462 ALVEETLVLVQTAGVQARVDFisELDNELSPINaDRELLKQVLLnILINAVQAISARGKI--RIQTWQYSDSQQAISIED 539
Cdd:PRK10618 531 EVLPEVLPAIKRKGLQLLIHN--HLKAEQLRIG-DRDALRKILL-LLLNYAITTTAYGKItlEVDQDESSPDRLTIRILD 606
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16130156 540 NGCGIDLSLQKKIFDPFFTTKAS-----GTGLGLALSQRIINAHQGDIRVASLPGYGATFTLILPINPQGNQT 607
Cdd:PRK10618 607 TGAGVSIKELDNLHFPFLNQTQGdrygkASGLTFFLCNQLCRKLGGHLTIKSREGLGTRYSIHLKMLAADPEV 679
|
|
| |
