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Conserved domains on  [gi|16130170|ref|NP_416738|]
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ribonucleoside-diphosphate reductase 1 subunit beta [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

ribonucleotide-diphosphate reductase subunit beta( domain architecture ID 10793142)

ribonucleotide-diphosphate reductase subunit beta catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides, providing the precursors necessary for DNA synthesis

CATH:  1.10.620.20
EC:  1.17.4.1
Gene Ontology:  GO:0009263|GO:0006260|GO:0046872|GO:0004748|GO:0005971
PubMed:  34461093|16756507
SCOP:  4000846

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
nrdB PRK09101
ribonucleotide-diphosphate reductase subunit beta; Reviewed
 1-376 0e+00

ribonucleotide-diphosphate reductase subunit beta; Reviewed


:

Pssm-ID: 181647  Cd Length: 376  Bit Score: 904.33  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170    1 MAYTTFSQTKNDQLKEPMFFGQPVNVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKY 80
Cdd:PRK09101   1 MAYTTFSQTKNDQLKEPMFFGQSVNVARYDQQKYEIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170   81 QTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPSVVFDDIVTNEQIQKRAEGISSYYDE 160
Cdd:PRK09101  81 QTLLDSIQGRSPNVALLPLVSIPELETWIETWSFSETIHSRSYTHIIRNIVNDPSVVFDDIVTNEEILKRAKDISSYYDD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170  161 LIEMTSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEA 240
Cdd:PRK09101 161 LIEMTSYYHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170  241 LHLTGTQHMLNLLRSGADDPEMAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVEYITNIRMQAV 320
Cdd:PRK09101 241 LHLTGTQHMLNLMRSGKDDPEMAEIAEECKQECYDLFVQAAEQEKEWADYLFKDGSMIGLNKDILCQYVEYITNIRMQAV 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 16130170  321 GLDLPFQTRSNPIPWINTWLVSDNVQVAPQEVEVSSYLVGQIDSEVDTDDLSNFQL 376
Cdd:PRK09101 321 GLDLPFQTRSNPIPWINAWLVSDNVQVAPQEVEVSSYLVGQIDSEVDTDDLSDFEL 376
 
Name Accession Description Interval E-value
nrdB PRK09101
ribonucleotide-diphosphate reductase subunit beta; Reviewed
 1-376 0e+00

ribonucleotide-diphosphate reductase subunit beta; Reviewed


Pssm-ID: 181647  Cd Length: 376  Bit Score: 904.33  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170    1 MAYTTFSQTKNDQLKEPMFFGQPVNVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKY 80
Cdd:PRK09101   1 MAYTTFSQTKNDQLKEPMFFGQSVNVARYDQQKYEIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170   81 QTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPSVVFDDIVTNEQIQKRAEGISSYYDE 160
Cdd:PRK09101  81 QTLLDSIQGRSPNVALLPLVSIPELETWIETWSFSETIHSRSYTHIIRNIVNDPSVVFDDIVTNEEILKRAKDISSYYDD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170  161 LIEMTSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEA 240
Cdd:PRK09101 161 LIEMTSYYHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170  241 LHLTGTQHMLNLLRSGADDPEMAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVEYITNIRMQAV 320
Cdd:PRK09101 241 LHLTGTQHMLNLMRSGKDDPEMAEIAEECKQECYDLFVQAAEQEKEWADYLFKDGSMIGLNKDILCQYVEYITNIRMQAV 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 16130170  321 GLDLPFQTRSNPIPWINTWLVSDNVQVAPQEVEVSSYLVGQIDSEVDTDDLSNFQL 376
Cdd:PRK09101 321 GLDLPFQTRSNPIPWINAWLVSDNVQVAPQEVEVSSYLVGQIDSEVDTDDLSDFEL 376
NrdB COG0208
Ribonucleotide reductase beta subunit, ferritin-like domain [Nucleotide transport and ...
 14-369 1.03e-141

Ribonucleotide reductase beta subunit, ferritin-like domain [Nucleotide transport and metabolism]; Ribonucleotide reductase beta subunit, ferritin-like domain is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 439978 [Multi-domain]  Cd Length: 326  Bit Score: 405.32  E-value: 1.03e-141
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170  14 LKEPMFFGQPVNVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLLDSIQGRSPN 93
Cdd:COG0208   1 LDEPIINGLTTNRINWNPIKYPWAYELYKKQLANFWLPEEVPLSNDIKDWKKLSDDERHLIKRVLGFLTLLDSIQGNNLV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170  94 VALLPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPSVVFDDIVTNEQIQKRAEGISSYYDELIEmtsywhllge 173
Cdd:COG0208  81 LALYPHVTAPEVRAVLSRQAFMEAIHAKSYSYILETLGLDIDEIFNWIEENPALQKKAEFILKYYDDLGT---------- 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170 174 gthtvngktvtvslRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNLL 253
Cdd:COG0208 151 --------------RETKKDLLKSLVASVFLEGIFFYSGFAYPLSLARRGKMKGTAEIIRLILRDESLHGNFGIYLINTI 216

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170 254 RsgADDPEMaeIAEECKQECYDLFVQAAQQEKDWADYLFrDGSMIGLNKDILCQYVEYITNIRMQAVGLDLPFQTRSNPI 333
Cdd:COG0208 217 R--EENPEL--FTEELKEEIYELLKEAVELEKEYADDLF-PDGILGLNAEDVKQYIRYIANKRLMNLGLEPLFEGDVNPF 291

                       330       340       350
                ....*....|....*....|....*....|....*.
gi 16130170 334 PWINTWLVSDNvQVAPQEVEVSSYLVGQIDSEVDTD 369
Cdd:COG0208 292 PWMSEGLDLNK-KTDFFETRVTEYQKGGVESTFDED 326
RNRR2 cd01049
Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Ribonucleotide ...
 29-341 3.52e-84

Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Ribonucleotide Reductase, R2/beta subunit (RNRR2) is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins. The RNR protein catalyzes the conversion of ribonucleotides to deoxyribonucleotides and is found in all eukaryotes, many prokaryotes, several viruses, and few archaea. The catalytically active form of RNR is a proposed alpha2-beta2 tetramer. The homodimeric alpha subunit (R1) contains the active site and redox active cysteines as well as the allosteric binding sites. The beta subunit (R2) contains a diiron cluster that, in its reduced state, reacts with dioxygen to form a stable tyrosyl radical and a diiron(III) cluster. This essential tyrosyl radical is proposed to generate a thiyl radical, located on a cysteine residue in the R1 active site that initiates ribonucleotide reduction. The beta subunit is composed of 10-13 helices, the 8 longest helices form an alpha-helical bundle; some have 2 addition beta strands. Yeast is unique in that it assembles both homodimers and heterodimers of RNRR2. The yeast heterodimer, Y2Y4, contains R2 (Y2) and a R2 homolog (Y4) that lacks the diiron center and is proposed to only assist in cofactor assembly, and perhaps stabilize R1 (Y1) in its active conformation.


Pssm-ID: 153108 [Multi-domain]  Cd Length: 288  Bit Score: 257.55  E-value: 3.52e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170  29 YDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLISIPELETW 108
Cdd:cd01049   3 LNPIKYPWAWELYKKAEANFWTPEEIDLSKDLKDWEKLTEAERHFIKRVLAFLAALDSIVGENLVELFSRHVQIPEARAF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170 109 VETWAFSETIHSRSYTHIIRNIVNDPSV--VFDDIVTNEQIQKRAEGISSYYDELIEMTsywhllgegthtvngktvtvs 186
Cdd:cd01049  83 YGFQAFMENIHSESYSYILDTLGKDEERdeLFEAIETDPALKKKADWILRWYDNLDDNT--------------------- 141

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170 187 lrelKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNLLRSGADDpemaEIA 266
Cdd:cd01049 142 ----KESFAERLVAFAILEGIFFYSGFAAIFWLARRGKMPGLAEIIELISRDESLHGDFACLLIRELLNENPE----LFT 213

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16130170 267 EECKQECYDLFVQAAQQEKDWADYLFRDGsMIGLNKDILCQYVEYITNIRMQAVGLDLPFQTR-SNPIPWINTWLV 341
Cdd:cd01049 214 EEFKEEVYELIKEAVELEKEFARDLLPDG-ILGLNKEDMKQYIEYVANRRLENLGLEKLFNVEdKNPFDWMELISD 288
Ribonuc_red_sm pfam00268
Ribonucleotide reductase, small chain;
33-332 3.51e-49

Ribonucleotide reductase, small chain;


Pssm-ID: 425568 [Multi-domain]  Cd Length: 276  Bit Score: 166.91  E-value: 3.51e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170    33 KYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLISIPELETWVETW 112
Cdd:pfam00268   8 KYPEIWEFYKKLEANFWTPEEIPLSKDIKDWKKLSEDEREFIKRVLAFLALLDTLVNENLVERFSREVQTPEARAFYGFQ 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170   113 AFSETIHSRSYTHIIRNIVNDPS---VVFDDIVTNEQIQKRAEGISSYYDELIEmtsywhllgegthtvngktvtvslrE 189
Cdd:pfam00268  88 AFMENIHSESYSYILDTLGKDPEeidELFNWIETNPALQKKAEWILKWYQDFDS-------------------------D 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170   190 LKKKLylcLMSVnALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNLLRSGADDPEmaeiAEEC 269
Cdd:pfam00268 143 FLERL---VAFA-ILEGIFFYSGFAAILWLKRRGKMPGLAEIIELISRDEGLHGDFACLLFQHLKEENPELE----TKEL 214

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16130170   270 KQECYDLFVQAAQQEKDWADYLFRDGsMIGLNKDILCQYVEYITNIRMQAVGLDLPFQTRSNP 332
Cdd:pfam00268 215 KEEVYDLIKEAVELEKEFLDDALPVG-LLGMNAEDVKQYIEYVADRRLMNLGYEKLYNVEVNP 276
 
Name Accession Description Interval E-value
nrdB PRK09101
ribonucleotide-diphosphate reductase subunit beta; Reviewed
 1-376 0e+00

ribonucleotide-diphosphate reductase subunit beta; Reviewed


Pssm-ID: 181647  Cd Length: 376  Bit Score: 904.33  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170    1 MAYTTFSQTKNDQLKEPMFFGQPVNVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKY 80
Cdd:PRK09101   1 MAYTTFSQTKNDQLKEPMFFGQSVNVARYDQQKYEIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170   81 QTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPSVVFDDIVTNEQIQKRAEGISSYYDE 160
Cdd:PRK09101  81 QTLLDSIQGRSPNVALLPLVSIPELETWIETWSFSETIHSRSYTHIIRNIVNDPSVVFDDIVTNEEILKRAKDISSYYDD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170  161 LIEMTSYWHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEA 240
Cdd:PRK09101 161 LIEMTSYYHLLGEGTHTVNGKTVTVSLRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170  241 LHLTGTQHMLNLLRSGADDPEMAEIAEECKQECYDLFVQAAQQEKDWADYLFRDGSMIGLNKDILCQYVEYITNIRMQAV 320
Cdd:PRK09101 241 LHLTGTQHMLNLMRSGKDDPEMAEIAEECKQECYDLFVQAAEQEKEWADYLFKDGSMIGLNKDILCQYVEYITNIRMQAV 320

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 16130170  321 GLDLPFQTRSNPIPWINTWLVSDNVQVAPQEVEVSSYLVGQIDSEVDTDDLSNFQL 376
Cdd:PRK09101 321 GLDLPFQTRSNPIPWINAWLVSDNVQVAPQEVEVSSYLVGQIDSEVDTDDLSDFEL 376
NrdB COG0208
Ribonucleotide reductase beta subunit, ferritin-like domain [Nucleotide transport and ...
 14-369 1.03e-141

Ribonucleotide reductase beta subunit, ferritin-like domain [Nucleotide transport and metabolism]; Ribonucleotide reductase beta subunit, ferritin-like domain is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 439978 [Multi-domain]  Cd Length: 326  Bit Score: 405.32  E-value: 1.03e-141
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170  14 LKEPMFFGQPVNVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLLDSIQGRSPN 93
Cdd:COG0208   1 LDEPIINGLTTNRINWNPIKYPWAYELYKKQLANFWLPEEVPLSNDIKDWKKLSDDERHLIKRVLGFLTLLDSIQGNNLV 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170  94 VALLPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPSVVFDDIVTNEQIQKRAEGISSYYDELIEmtsywhllge 173
Cdd:COG0208  81 LALYPHVTAPEVRAVLSRQAFMEAIHAKSYSYILETLGLDIDEIFNWIEENPALQKKAEFILKYYDDLGT---------- 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170 174 gthtvngktvtvslRELKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNLL 253
Cdd:COG0208 151 --------------RETKKDLLKSLVASVFLEGIFFYSGFAYPLSLARRGKMKGTAEIIRLILRDESLHGNFGIYLINTI 216

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170 254 RsgADDPEMaeIAEECKQECYDLFVQAAQQEKDWADYLFrDGSMIGLNKDILCQYVEYITNIRMQAVGLDLPFQTRSNPI 333
Cdd:COG0208 217 R--EENPEL--FTEELKEEIYELLKEAVELEKEYADDLF-PDGILGLNAEDVKQYIRYIANKRLMNLGLEPLFEGDVNPF 291

                       330       340       350
                ....*....|....*....|....*....|....*.
gi 16130170 334 PWINTWLVSDNvQVAPQEVEVSSYLVGQIDSEVDTD 369
Cdd:COG0208 292 PWMSEGLDLNK-KTDFFETRVTEYQKGGVESTFDED 326
RNRR2 cd01049
Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Ribonucleotide ...
 29-341 3.52e-84

Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Ribonucleotide Reductase, R2/beta subunit (RNRR2) is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins. The RNR protein catalyzes the conversion of ribonucleotides to deoxyribonucleotides and is found in all eukaryotes, many prokaryotes, several viruses, and few archaea. The catalytically active form of RNR is a proposed alpha2-beta2 tetramer. The homodimeric alpha subunit (R1) contains the active site and redox active cysteines as well as the allosteric binding sites. The beta subunit (R2) contains a diiron cluster that, in its reduced state, reacts with dioxygen to form a stable tyrosyl radical and a diiron(III) cluster. This essential tyrosyl radical is proposed to generate a thiyl radical, located on a cysteine residue in the R1 active site that initiates ribonucleotide reduction. The beta subunit is composed of 10-13 helices, the 8 longest helices form an alpha-helical bundle; some have 2 addition beta strands. Yeast is unique in that it assembles both homodimers and heterodimers of RNRR2. The yeast heterodimer, Y2Y4, contains R2 (Y2) and a R2 homolog (Y4) that lacks the diiron center and is proposed to only assist in cofactor assembly, and perhaps stabilize R1 (Y1) in its active conformation.


Pssm-ID: 153108 [Multi-domain]  Cd Length: 288  Bit Score: 257.55  E-value: 3.52e-84
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170  29 YDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLISIPELETW 108
Cdd:cd01049   3 LNPIKYPWAWELYKKAEANFWTPEEIDLSKDLKDWEKLTEAERHFIKRVLAFLAALDSIVGENLVELFSRHVQIPEARAF 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170 109 VETWAFSETIHSRSYTHIIRNIVNDPSV--VFDDIVTNEQIQKRAEGISSYYDELIEMTsywhllgegthtvngktvtvs 186
Cdd:cd01049  83 YGFQAFMENIHSESYSYILDTLGKDEERdeLFEAIETDPALKKKADWILRWYDNLDDNT--------------------- 141

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170 187 lrelKKKLYLCLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNLLRSGADDpemaEIA 266
Cdd:cd01049 142 ----KESFAERLVAFAILEGIFFYSGFAAIFWLARRGKMPGLAEIIELISRDESLHGDFACLLIRELLNENPE----LFT 213

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16130170 267 EECKQECYDLFVQAAQQEKDWADYLFRDGsMIGLNKDILCQYVEYITNIRMQAVGLDLPFQTR-SNPIPWINTWLV 341
Cdd:cd01049 214 EEFKEEVYELIKEAVELEKEFARDLLPDG-ILGLNKEDMKQYIEYVANRRLENLGLEKLFNVEdKNPFDWMELISD 288
nrdF PRK09614
ribonucleotide-diphosphate reductase subunit beta; Reviewed
 17-374 4.05e-51

ribonucleotide-diphosphate reductase subunit beta; Reviewed


Pssm-ID: 236591 [Multi-domain]  Cd Length: 324  Bit Score: 173.47  E-value: 4.05e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170   17 PMFFGQPVNVARYDQQKYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLLDSIQGRSPNVAL 96
Cdd:PRK09614   2 KIIGGNTYSAINWNKIEDPWDYEAWKRLTANFWLPEEVPLSNDLKDWKKLSDEEKNLYTRVFGGLTLLDTLQNNNGMPNL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170   97 LPLISIPELETWVETWAFSETIHSRSYTHIIRNIVNDPSV--VFDDIVTNEQIQKRAEGISSYYdeliemtsywhllgeg 174
Cdd:PRK09614  82 MPDITTPEEEAVLANIAFMEAVHAKSYSYIFSTLCSPEEIdeAFEWAEENPYLQKKADIIQDFY---------------- 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170  175 thtvngktvtvslRELKKKLYLCLMSVNA-LEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNLL 253
Cdd:PRK09614 146 -------------EPLKKKILRKAAVASVfLEGFLFYSGFYYPLYLARQGKMTGTAQIIRLIIRDESLHGYYIGYLFQEG 212

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170  254 RSGADDPEMAEIaeecKQECYDLFVQAAQQEKDWADYLFRDgsmIGLNKDILcQYVEYITNIRMQAVGLDLPFQTR-SNP 332
Cdd:PRK09614 213 LEELPELEQEEL----KDEIYDLLYELYENEEAYTELLYDI---VGLAEDVK-KYIRYNANKRLMNLGLEPLFPEEeEVN 284

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|...
gi 16130170  333 IPWINTwLVSDNVQVAPQ-EVEVSSYLVGQidSEVDTDDLSNF 374
Cdd:PRK09614 285 PIWLNG-LSNNADENHDFfEGKGTSYVKGA--TEATEDDDWDF 324
Ribonuc_red_sm pfam00268
Ribonucleotide reductase, small chain;
33-332 3.51e-49

Ribonucleotide reductase, small chain;


Pssm-ID: 425568 [Multi-domain]  Cd Length: 276  Bit Score: 166.91  E-value: 3.51e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170    33 KYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLISIPELETWVETW 112
Cdd:pfam00268   8 KYPEIWEFYKKLEANFWTPEEIPLSKDIKDWKKLSEDEREFIKRVLAFLALLDTLVNENLVERFSREVQTPEARAFYGFQ 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170   113 AFSETIHSRSYTHIIRNIVNDPS---VVFDDIVTNEQIQKRAEGISSYYDELIEmtsywhllgegthtvngktvtvslrE 189
Cdd:pfam00268  88 AFMENIHSESYSYILDTLGKDPEeidELFNWIETNPALQKKAEWILKWYQDFDS-------------------------D 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170   190 LKKKLylcLMSVnALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNLLRSGADDPEmaeiAEEC 269
Cdd:pfam00268 143 FLERL---VAFA-ILEGIFFYSGFAAILWLKRRGKMPGLAEIIELISRDEGLHGDFACLLFQHLKEENPELE----TKEL 214

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16130170   270 KQECYDLFVQAAQQEKDWADYLFRDGsMIGLNKDILCQYVEYITNIRMQAVGLDLPFQTRSNP 332
Cdd:pfam00268 215 KEEVYDLIKEAVELEKEFLDDALPVG-LLGMNAEDVKQYIEYVADRRLMNLGYEKLYNVEVNP 276
PRK07209 PRK07209
ribonucleotide-diphosphate reductase subunit beta; Validated
 49-335 4.85e-21

ribonucleotide-diphosphate reductase subunit beta; Validated


Pssm-ID: 235968  Cd Length: 369  Bit Score: 93.14  E-value: 4.85e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170   49 WRPEEVDVSRDrI----DYQALPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSYT 124
Cdd:PRK07209  71 WMPQEVNMSRD-IalwkSPNGLTEDERRIVKRNLGFFSTADSLVANNIVLAIYRHITNPECRQYLLRQAFEEAIHTHAYQ 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170  125 HIIRNIVNDPSVVFDDIVTNEQIQKRAEGISSYYDELIEMtsywhllgegthtvNGKTVTV-SLRELKKKL--YLCLMsv 201
Cdd:PRK07209 150 YIVESLGLDEGEIFNMYHEVPSIRAKDEFLIPFTRSLTDP--------------NFKTGTPeNDQKLLRNLiaFYCIM-- 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170  202 nalEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNLLRsgADDPEMAeiAEECKQECYDLFVQAA 281
Cdd:PRK07209 214 ---EGIFFYVGFTQILSLGRQNKMTGIAEQYQYILRDESMHLNFGIDLINQIK--LENPHLW--TAEFQAEIRELIKEAV 286

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 16130170  282 QQEKDWA-DYLFRDgsMIGLNKDILCQYVEYITNIRMQAVGLDLPFQTRSNPIPW 335
Cdd:PRK07209 287 ELEYRYArDTMPRG--VLGLNASMFKDYLRFIANRRLQQIGLKPQYPGTENPFPW 339
PRK13965 PRK13965
ribonucleotide-diphosphate reductase subunit beta; Provisional
 1-332 1.43e-19

ribonucleotide-diphosphate reductase subunit beta; Provisional


Pssm-ID: 184425 [Multi-domain]  Cd Length: 335  Bit Score: 88.68  E-value: 1.43e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170    1 MAYTTFSQTKND-QLKEPMFFGQPVNVARYDQQK-YDIFEKLIEKqlsfFWRPEEVDVSRDRIDYQALPEHEKHIFISNL 78
Cdd:PRK13965   1 QSYYDRSQSPIEyALSETQKPLRSINWNYLNDDKdLEVWNRVTQN----FWLPEKVPVSNDLNSWRSLGEDWQQLITRTF 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170   79 KYQTLLDSIQGRSPNVALLPlISIPELETWVET-WAFSETIHSRSYTHIIRNIVNDPSV--VFDDIVTNEQIQKRAEGIS 155
Cdd:PRK13965  77 TGLTLLDTVQATVGDVAQIP-HSQTDHEQVIYTnFAFMVAIHARSYGTIFSTLCSSEQIeeAHEWVVSTESLQRRARVLI 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170  156 SYYDeliemtsywhllGEGThtvngktvtvslreLKKKLYLCLMSvnaleAIRFYVSFACSFAFAERELMEGNAKIIRLI 235
Cdd:PRK13965 156 PYYT------------GDDP--------------LKSKVAAAMMP-----GFLLYGGFYLPFYLSARGKLPNTSDIIRLI 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170  236 ARDEALH--LTGTQHMLNLlrsgadDPEMAEIAEECKQECYDLFVQAAQQEKDWADYLFRDgsmIGLNKDILcQYVEYIT 313
Cdd:PRK13965 205 LRDKVIHnyYSGYKYQQKV------ARLSPEKQAEMKAFVFDLLYELIDLEKAYLRELYAG---FDLAEDAI-RFSLYNA 274

                        330       340
                 ....*....|....*....|..
gi 16130170  314 NIRMQAVGLDLPF---QTRSNP 332
Cdd:PRK13965 275 GKFLQNLGYESPFteeETRVSP 296
PTZ00211 PTZ00211
ribonucleoside-diphosphate reductase small subunit; Provisional
 7-357 1.05e-17

ribonucleoside-diphosphate reductase small subunit; Provisional


Pssm-ID: 240315 [Multi-domain]  Cd Length: 330  Bit Score: 82.89  E-value: 1.05e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170    7 SQTKNDQLKEPMFFGQPVNVARYDQQKYDIFEKLiEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHiFISN-LKYQTLLD 85
Cdd:PTZ00211   3 EAMKENEEEEPLLKENPDRFVLFPIKYPDIWRMY-KKAEASFWTAEEIDLGNDLKDWEKLNDGERH-FIKHvLAFFAASD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170   86 SIQGRSPNVALLPLISIPELETWvetWAFS---ETIHSRSYTHIIRNIVNDPS---VVFDDIVTNEQIQKRAEgissyyd 159
Cdd:PTZ00211  81 GIVLENLAQRFMREVQVPEARCF---YGFQiamENIHSETYSLLIDTYITDEEekdRLFHAIETIPAIKKKAE------- 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170  160 eliemtsyWhllgeGTHTVNGKTvtvSLRELkkklylcLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDE 239
Cdd:PTZ00211 151 --------W-----AAKWINSSN---SFAER-------LVAFAAVEGIFFSGSFCAIFWLKKRGLMPGLTFSNELISRDE 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170  240 ALHLTGTQHMLNLLRSGADDPEMAEIAEEckqecydlfvqAAQQEKDW-ADYLFRDgsMIGLNKDILCQYVEYITNIRMQ 318
Cdd:PTZ00211 208 GLHTDFACLLYSHLKNKLPRERVQEIIKE-----------AVEIEREFiCDALPVD--LIGMNSRLMAQYIEFVADRLLV 274

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 16130170  319 AVGLDLPFQTrSNPIPWINtwLVSDNVQVAPQEVEVSSY 357
Cdd:PTZ00211 275 ALGVPKIYNS-KNPFDWMD--MISLQGKTNFFEKRVGEY 310
nrdF2 PRK13966
ribonucleotide-diphosphate reductase subunit beta; Provisional
 48-332 8.16e-17

ribonucleotide-diphosphate reductase subunit beta; Provisional


Pssm-ID: 140022  Cd Length: 324  Bit Score: 80.53  E-value: 8.16e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170   48 FWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSYTHII 127
Cdd:PRK13966  35 FWLPEKVPVSNDIPSWGTLTAGEKQLTMRVFTGLTMLDTIQGTVGAVSLIPDALTPHEEAVLTNIAFMESVHAKSYSQIF 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170  128 RNIVNDPSV--VFDDIVTNEQIQKRAEGISSYY--DEliemtsywhllgegthtvngktvtvslrELKKKLYLCLmsvna 203
Cdd:PRK13966 115 STLCSTAEIddAFRWSEENRNLQRKAEIVLQYYrgDE----------------------------PLKRKVASTL----- 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170  204 LEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALH--LTGTQHMLNLlrsgaddpemAEIAEECKQE----CYDLF 277
Cdd:PRK13966 162 LESFLFYSGFYLPMYWSSRAKLTNTADMIRLIIRDEAVHgyYIGYKFQRGL----------ALVDDVTRAElkdyTYELL 231

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 16130170  278 VQAAQQEKDWADYLFrdgSMIGLNKDILcQYVEYITNIRMQAVGLDLPF---QTRSNP 332
Cdd:PRK13966 232 FELYDNEVEYTQDLY---DEVGLTEDVK-KFLRYNANKALMNLGYEALFprdETDVNP 285
nrdF1 PRK13967
ribonucleotide-diphosphate reductase subunit beta; Provisional
 30-326 2.68e-14

ribonucleotide-diphosphate reductase subunit beta; Provisional


Pssm-ID: 140023  Cd Length: 322  Bit Score: 72.84  E-value: 2.68e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170   30 DQQKYDIFEKLIEKqlsfFWRPEEVDVSRDRIDYQALPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLISIPELETWV 109
Cdd:PRK13967  19 DAKDLQVWERLTGN----FWLPEKIPLSNDLASWQTLSSTEQQTTIRVFTGLTLLDTAQATVGAVAMIDDAVTPHEEAVL 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170  110 ETWAFSETIHSRSYTHIIRNIVNDPSV--VFDDIVTNEQIQKRAEGISSYYdeliemtsywhllgEGTHTVNGKTVTVsl 187
Cdd:PRK13967  95 TNMAFMESVHAKSYSSIFSTLCSTKQIddAFDWSEQNPYLQRKAQIIVDYY--------------RGDDALKRKASSV-- 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170  188 relkkklylclmsvnALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHltgTQHMLNLLRSGADDPEMAEIAE 267
Cdd:PRK13967 159 ---------------MLESFLFYSGFYLPMYWSSRGKLTNTADLIRLIIRDEAVH---GYYIGYKCQRGLADLTDAERAD 220

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 16130170  268 ECKQECyDLFVQAAQQEKDWADYLFRDgsmIGLNKDILcQYVEYITNIRMQAVGLDLPF 326
Cdd:PRK13967 221 HREYTC-ELLHTLYANEIDYAHDLYDE---LGWTDDVL-PYMRYNANKALANLGYQPAF 274
PRK12759 PRK12759
bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta; Provisional
 49-367 6.56e-14

bifunctional gluaredoxin/ribonucleoside-diphosphate reductase subunit beta; Provisional


Pssm-ID: 139206 [Multi-domain]  Cd Length: 410  Bit Score: 72.37  E-value: 6.56e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170   49 WRPEEVDVSRDRIDYQ--ALPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLISIPELETWVETWAFSETIHSRSYThi 126
Cdd:PRK12759 120 WIEDEIDLSEDVTDWKngKITKVEKEYITNILRLFTQSDVAVGQNYYDQFIPLFKNNEIRNMLGSFAAREGIHQRAYA-- 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170  127 irnIVNDPSVVFDdivtneqiqkraegisSYYDELIE---MTSYWHLLGEGTHTVngktvtvslrelKKKLYLCLMSVNA 203
Cdd:PRK12759 198 ---LLNDTLGLPD----------------SEYHAFLEykaMTDKIDFMMDADPTT------------RRGLGLCLAKTVF 246

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170  204 LEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNLLrsGADDPEMAEiaEECKQECYDLFVQAAQQ 283
Cdd:PRK12759 247 NEGVALFASFAMLLNFQRFGKMKGMGKVVEWSIRDESMHVEGNAALFRIY--CQENPYIVD--NEFKKEIYLMASKAVEL 322

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170  284 EKDWADYLFRDGSMIGLNKDILCQYVEYITNIRMQAVGLDLPFQTRSNPIPWINtWLVSDNVQVAPQEVEVSSYLVGQID 363
Cdd:PRK12759 323 EDRFIELAYELGTIEGLKADEVKQYIRHITDRRLNQLGLKEIYNIEKNPLTWLE-WILNGADHTNFFENRVTEYEVAGLT 401


                 ....
gi 16130170  364 SEVD 367
Cdd:PRK12759 402 GSWD 405
PLN02492 PLN02492
ribonucleoside-diphosphate reductase
 33-336 7.00e-12

ribonucleoside-diphosphate reductase


Pssm-ID: 215272  Cd Length: 324  Bit Score: 65.84  E-value: 7.00e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170   33 KYDIFEKLIEKQLSFFWRPEEVDVSRDRIDYQALPEHEKHiFISN-LKYQTLLDSIQGRSPNVALLPLISIPELETWvet 111
Cdd:PLN02492  17 KYPQIWEMYKKAEASFWTAEEVDLSADLKDWEKLTDDERH-FISHvLAFFAASDGIVLENLAARFMKEVQVPEARAF--- 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170  112 WAFS---ETIHSRSYTHIIRNIVNDPSV---VFDDIVTNEQIQKRAEgissyydeliemtsyWHLLGEGTHTvngktvtv 185
Cdd:PLN02492  93 YGFQiaiENIHSEMYSLLLDTYIKDPKEkdrLFNAIETIPCVAKKAD---------------WALRWIDSSA-------- 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130170  186 SLRELkkklylcLMSVNALEAIRFYVSFACSFAFAERELMEGNAKIIRLIARDEALHLTGTQHMLNLLRSGADDPEMAEI 265
Cdd:PLN02492 150 SFAER-------LVAFACVEGIFFSGSFCAIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLLYSLLKNKLSEERVKEI 222

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16130170  266 AEEckqecydlfvqAAQQEKDW-ADYLfrDGSMIGLNKDILCQYVEYITNIRMQAVGLDLPFQTRsNPIPWI 336
Cdd:PLN02492 223 VCE-----------AVEIEKEFvCDAL--PCALVGMNADLMSQYIEFVADRLLVALGYEKVYNVV-NPFDWM 280
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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