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Conserved domains on  [gi|90111419|ref|NP_416833|]
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ribosomal protein L3 N(5)-glutamine methyltransferase [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

ribosomal protein L3 N(5)-glutamine methyltransferase( domain architecture ID 11497021)

ribosomal protein L3 N(5)-glutamine methyltransferase specifically methylates the 50S ribosomal protein L3 on Gln-150 using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; does not methylate the translation termination release factors RF1 and RF2; belongs to the class I SAM-dependent methyltransferase superfamily

CATH:  2.20.25.110
EC:  2.1.1.298
Gene Ontology:  GO:0008757|GO:0006479|GO:1904047|GO:0018364
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
L3_gln_methyl TIGR03533
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this ...
 13-295 0e+00

protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this protein family methylate ribosomal protein L3 on a glutamine side chain. This family is related to HemK, a protein-glutamine methyltranferase for peptide chain release factors. [Protein synthesis, Ribosomal proteins: synthesis and modification]


:

Pssm-ID: 274633 [Multi-domain]  Cd Length: 284  Bit Score: 567.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419    13 LQTIQDMLRWSVSRFSAANIWYGHGTDNPWDEAVQLVLPSLYLPLDIPEDMRTARLTSSEKHRIVERVIRRVNERIPVAY 92
Cdd:TIGR03533   1 LHTIRDFLRWAVSRFNAAGLFFGHGTDNAWDEAVYLVLHALHLPLDILEPFLDARLTPSEKERILELIERRIEERIPVAY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419    93 LTNKAWFCGHEFYVDERVLVPRSPIGELINNKFAGLISK-QPQHILDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAV 171
Cdd:TIGR03533  81 LTNEAWFAGLEFYVDERVLIPRSPIAELIEDGFAPWLEPePVKRILDLCTGSGCIAIACAYAFPEAEVDAVDISPDALAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419   172 AEQNIEEHGLIHNVIPIRSDLFRDLPKVQYDLIVTNPPYVDAEDMSDLPNEYRHEPELGLASGTDGLKLTRRILGNAADY 251
Cdd:TIGR03533 161 AEINIERHGLEDRVTLIQSDLFAALPGRKYDLIVSNPPYVDAEDMADLPAEYHHEPELALASGEDGLDLVRRILAEAADH 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 90111419   252 LADDGVLICEVGNSMVHLMEQYPDVPFTWLEFDNGGDGVFMLTK 295
Cdd:TIGR03533 241 LNENGVLVVEVGNSMEALEEAYPDVPFTWLEFENGGDGVFLLTR 284
 
Name Accession Description Interval E-value
L3_gln_methyl TIGR03533
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this ...
 13-295 0e+00

protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this protein family methylate ribosomal protein L3 on a glutamine side chain. This family is related to HemK, a protein-glutamine methyltranferase for peptide chain release factors. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 274633 [Multi-domain]  Cd Length: 284  Bit Score: 567.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419    13 LQTIQDMLRWSVSRFSAANIWYGHGTDNPWDEAVQLVLPSLYLPLDIPEDMRTARLTSSEKHRIVERVIRRVNERIPVAY 92
Cdd:TIGR03533   1 LHTIRDFLRWAVSRFNAAGLFFGHGTDNAWDEAVYLVLHALHLPLDILEPFLDARLTPSEKERILELIERRIEERIPVAY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419    93 LTNKAWFCGHEFYVDERVLVPRSPIGELINNKFAGLISK-QPQHILDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAV 171
Cdd:TIGR03533  81 LTNEAWFAGLEFYVDERVLIPRSPIAELIEDGFAPWLEPePVKRILDLCTGSGCIAIACAYAFPEAEVDAVDISPDALAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419   172 AEQNIEEHGLIHNVIPIRSDLFRDLPKVQYDLIVTNPPYVDAEDMSDLPNEYRHEPELGLASGTDGLKLTRRILGNAADY 251
Cdd:TIGR03533 161 AEINIERHGLEDRVTLIQSDLFAALPGRKYDLIVSNPPYVDAEDMADLPAEYHHEPELALASGEDGLDLVRRILAEAADH 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 90111419   252 LADDGVLICEVGNSMVHLMEQYPDVPFTWLEFDNGGDGVFMLTK 295
Cdd:TIGR03533 241 LNENGVLVVEVGNSMEALEEAYPDVPFTWLEFENGGDGVFLLTR 284
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 15-266 1.45e-105

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 309.39  E-value: 1.45e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419  15 TIQDMLRWSVSRFSAAniwyghGTDNPWDEAVQLVLPSLYLPLDIPEDMRTARLTSSEKHRIVERVIRRVnERIPVAYLT 94
Cdd:COG2890   2 TIRELLRWAAARLAAA------GVDSARLEAELLLAHVLGLDRADLLLHPDRPLTEEELARLEALVARRA-AGEPLAYIL 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419  95 NKAWFCGHEFYVDERVLVPRSPIGELINNKFAGLISKQPQHILDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAVAEQ 174
Cdd:COG2890  75 GEAEFYGLEFKVDPGVLIPRPETEELVELALALLPAGAPPRVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVARR 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419 175 NIEEHGLIHNVIPIRSDLFRDLPKV-QYDLIVTNPPYVDAEDMSDLPNEYR-HEPELGLASGTDGLKLTRRILGNAADYL 252
Cdd:COG2890 155 NAERLGLEDRVRFLQGDLFEPLPGDgRFDLIVSNPPYIPEDEIALLPPEVRdHEPRLALDGGEDGLDFYRRIIAQAPRLL 234

                       250
                ....*....|....
gi 90111419 253 ADDGVLICEVGNSM 266
Cdd:COG2890 235 KPGGWLLLEIGEDQ 248
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 14-263 2.67e-69

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 216.57  E-value: 2.67e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419   14 QTIQDMLRWSVSRFSAaniwyghgtdnPWDEAVQLV-----LPSLYLPLDIPEDmrtarLTSSEKHRIVERVIRRVNeRI 88
Cdd:PRK09328   2 MTIAEALREATARLAS-----------PRLDAELLLahvlgLSRTDLLLNPEEE-----LTPEELERFRALVARRAA-GE 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419   89 PVAYLTNKAWFCGHEFYVDERVLVPRsP-----IGELINNKFAglisKQPQHILDMCTGSGCIAIACAYAFPDAEVDAVD 163
Cdd:PRK09328  65 PLQYILGEAEFWGLDFKVSPGVLIPR-PeteelVEWALEALLL----KEPLRVLDLGTGSGAIALALAKERPDAEVTAVD 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419  164 ISPDALAVAEQNIeEHGLIHNVIPIRSDLFRDLPKVQYDLIVTNPPYVDAEDMSDLPNEYR-HEPELGLASGTDGLKLTR 242
Cdd:PRK09328 140 ISPEALAVARRNA-KHGLGARVEFLQGDWFEPLPGGRFDLIVSNPPYIPEADIHLLQPEVRdHEPHLALFGGEDGLDFYR 218

                        250       260
                 ....*....|....*....|.
gi 90111419  243 RILGNAADYLADDGVLICEVG 263
Cdd:PRK09328 219 RIIEQAPRYLKPGGWLLLEIG 239
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 134-265 9.09e-19

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 81.87  E-value: 9.09e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419   134 QHILDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAVAEQNIEEHGLiHNVIPIRSDLFRDLPKVQYDLIVTNPPYvda 213
Cdd:pfam05175  33 GKVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGL-ENGEVVASDVYSGVEDGKFDLIISNPPF--- 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 90111419   214 edmsdlpneyrHEpelGLASGTDglkLTRRILGNAADYLADDGVLICeVGNS 265
Cdd:pfam05175 109 -----------HA---GLATTYN---VAQRFIADAKRHLRPGGELWI-VANR 142
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 136-262 5.63e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 55.90  E-value: 5.63e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419 136 ILDMCTGSGCIAIAcAYAFPDAEVDAVDISPDALAVAEQNiEEHGLIHNVIPIRSDLFRDLPKV--QYDLIVTNPPYVDA 213
Cdd:cd02440   2 VLDLGCGTGALALA-LASGPGARVTGVDISPVALELARKA-AAALLADNVEVLKGDAEELPPEAdeSFDVIISDPPLHHL 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 90111419 214 EDmsdlpneyrhepelglasgtdglkLTRRILGNAADYLADDGVLICEV 262
Cdd:cd02440  80 VE------------------------DLARFLEEARRLLKPGGVLVLTL 104
 
Name Accession Description Interval E-value
L3_gln_methyl TIGR03533
protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this ...
 13-295 0e+00

protein-(glutamine-N5) methyltransferase, ribosomal protein L3-specific; Members of this protein family methylate ribosomal protein L3 on a glutamine side chain. This family is related to HemK, a protein-glutamine methyltranferase for peptide chain release factors. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 274633 [Multi-domain]  Cd Length: 284  Bit Score: 567.91  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419    13 LQTIQDMLRWSVSRFSAANIWYGHGTDNPWDEAVQLVLPSLYLPLDIPEDMRTARLTSSEKHRIVERVIRRVNERIPVAY 92
Cdd:TIGR03533   1 LHTIRDFLRWAVSRFNAAGLFFGHGTDNAWDEAVYLVLHALHLPLDILEPFLDARLTPSEKERILELIERRIEERIPVAY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419    93 LTNKAWFCGHEFYVDERVLVPRSPIGELINNKFAGLISK-QPQHILDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAV 171
Cdd:TIGR03533  81 LTNEAWFAGLEFYVDERVLIPRSPIAELIEDGFAPWLEPePVKRILDLCTGSGCIAIACAYAFPEAEVDAVDISPDALAV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419   172 AEQNIEEHGLIHNVIPIRSDLFRDLPKVQYDLIVTNPPYVDAEDMSDLPNEYRHEPELGLASGTDGLKLTRRILGNAADY 251
Cdd:TIGR03533 161 AEINIERHGLEDRVTLIQSDLFAALPGRKYDLIVSNPPYVDAEDMADLPAEYHHEPELALASGEDGLDLVRRILAEAADH 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 90111419   252 LADDGVLICEVGNSMVHLMEQYPDVPFTWLEFDNGGDGVFMLTK 295
Cdd:TIGR03533 241 LNENGVLVVEVGNSMEALEEAYPDVPFTWLEFENGGDGVFLLTR 284
hemK_fam TIGR00536
HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme ...
 14-303 1.07e-143

HemK family putative methylases; The gene hemK from E. coli was found to contribute to heme biosynthesis and originally suggested to be protoporphyrinogen oxidase. Functional analysis of the nearest homolog in Saccharomyces cerevisiae, YNL063w, finds it is not protoporphyrinogen oxidase and sequence analysis suggests that HemK homologs have S-adenosyl-methionine-dependent methyltransferase activity (Medline 99237242). Homologs are found, usually in a single copy, in nearly all completed genomes, but varying somewhat in apparent domain architecture. Both E. coli and H. influenzae have two members rather than one. The members from the Mycoplasmas have an additional C-terminal domain. [Protein fate, Protein modification and repair]


Pssm-ID: 273125 [Multi-domain]  Cd Length: 284  Bit Score: 405.97  E-value: 1.07e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419    14 QTIQDMLRWSVSRFSAANIWyghgtDNPWDEAVQLVLPSLYLPLDIPEDMRTARLTSSEKHRIVERVIRRVNErIPVAYL 93
Cdd:TIGR00536   1 MTIQEFLRWASSALSRAIAR-----ENPWLEALLLLEHDLGRERDLLLAFLTEELTPDEKERIFRLVLRRVKG-VPVAYL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419    94 TNKAWFCGHEFYVDERVLVPRSPIGELINNKFAGLISKQP-QHILDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAVA 172
Cdd:TIGR00536  75 LGSKEFYGLEFFVNEHVLIPRPETEELVEKALASLISQPPiLHILDLGTGSGCIALALAYEFPNAEVIAVDISPDALAVA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419   173 EQNIEEHGLIHNVIPIRSDLFRDLPKVQYDLIVTNPPYVDAEDMSDLPNEYRHEPELGLASGTDGLKLTRRILGNAADYL 252
Cdd:TIGR00536 155 EENAEKNQLEHRVEFIQSNLFEPLAGQKIDIIVSNPPYIDEEDLADLPNVVRFEPLLALVGGDDGLNILRQIIELAPDYL 234

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 90111419   253 ADDGVLICEVGNSMVHLMEQYPDVPFTWLEFDNGGDgVFMLTKEQLIAARE 303
Cdd:TIGR00536 235 KPNGFLVCEIGNWQQKSLKELLRIKFTWYDVENGRD-LNGKERVVLGFYHS 284
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 15-266 1.45e-105

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 309.39  E-value: 1.45e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419  15 TIQDMLRWSVSRFSAAniwyghGTDNPWDEAVQLVLPSLYLPLDIPEDMRTARLTSSEKHRIVERVIRRVnERIPVAYLT 94
Cdd:COG2890   2 TIRELLRWAAARLAAA------GVDSARLEAELLLAHVLGLDRADLLLHPDRPLTEEELARLEALVARRA-AGEPLAYIL 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419  95 NKAWFCGHEFYVDERVLVPRSPIGELINNKFAGLISKQPQHILDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAVAEQ 174
Cdd:COG2890  75 GEAEFYGLEFKVDPGVLIPRPETEELVELALALLPAGAPPRVLDLGTGSGAIALALAKERPDARVTAVDISPDALAVARR 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419 175 NIEEHGLIHNVIPIRSDLFRDLPKV-QYDLIVTNPPYVDAEDMSDLPNEYR-HEPELGLASGTDGLKLTRRILGNAADYL 252
Cdd:COG2890 155 NAERLGLEDRVRFLQGDLFEPLPGDgRFDLIVSNPPYIPEDEIALLPPEVRdHEPRLALDGGEDGLDFYRRIIAQAPRLL 234

                       250
                ....*....|....
gi 90111419 253 ADDGVLICEVGNSM 266
Cdd:COG2890 235 KPGGWLLLEIGEDQ 248
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 14-263 2.67e-69

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 216.57  E-value: 2.67e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419   14 QTIQDMLRWSVSRFSAaniwyghgtdnPWDEAVQLV-----LPSLYLPLDIPEDmrtarLTSSEKHRIVERVIRRVNeRI 88
Cdd:PRK09328   2 MTIAEALREATARLAS-----------PRLDAELLLahvlgLSRTDLLLNPEEE-----LTPEELERFRALVARRAA-GE 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419   89 PVAYLTNKAWFCGHEFYVDERVLVPRsP-----IGELINNKFAglisKQPQHILDMCTGSGCIAIACAYAFPDAEVDAVD 163
Cdd:PRK09328  65 PLQYILGEAEFWGLDFKVSPGVLIPR-PeteelVEWALEALLL----KEPLRVLDLGTGSGAIALALAKERPDAEVTAVD 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419  164 ISPDALAVAEQNIeEHGLIHNVIPIRSDLFRDLPKVQYDLIVTNPPYVDAEDMSDLPNEYR-HEPELGLASGTDGLKLTR 242
Cdd:PRK09328 140 ISPEALAVARRNA-KHGLGARVEFLQGDWFEPLPGGRFDLIVSNPPYIPEADIHLLQPEVRdHEPHLALFGGEDGLDFYR 218

                        250       260
                 ....*....|....*....|.
gi 90111419  243 RILGNAADYLADDGVLICEVG 263
Cdd:PRK09328 219 RIIEQAPRYLKPGGWLLLEIG 239
RF_mod_PrmC TIGR03534
protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein ...
 68-274 1.36e-66

protein-(glutamine-N5) methyltransferase, release factor-specific; Members of this protein family are HemK (PrmC), a protein once thought to be involved in heme biosynthesis but now recognized to be a protein-glutamine methyltransferase that modifies the peptide chain release factors. All members of the seed alignment are encoded next to the release factor 1 gene (prfA) and confirmed by phylogenetic analysis. SIMBAL analysis (manuscript in prep.) shows the motif [LIV]PRx[DE]TE (in Escherichia coli, IPRPDTE) confers specificity for the release factors rather than for ribosomal protein L3. [Protein fate, Protein modification and repair]


Pssm-ID: 274634 [Multi-domain]  Cd Length: 250  Bit Score: 208.86  E-value: 1.36e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419    68 LTSSEKHRIVERVIRRVnERIPVAYLTNKAWFCGHEFYVDERVLVPRsPIGELINNKFAGLISKQPqHILDMCTGSGCIA 147
Cdd:TIGR03534  25 LTPEELAAFDALLARRA-AGEPVAYILGEREFYGLDFKVSPGVLIPR-PETEELVEAALERLKKGP-RVLDLGTGSGAIA 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419   148 IACAYAFPDAEVDAVDISPDALAVAEQNIEEHGLiHNVIPIRSDLFRDLPKVQYDLIVTNPPYVDAEDMSDLPNEYR-HE 226
Cdd:TIGR03534 102 LALAKERPDARVTAVDISPEALAVARKNARRLGL-ENVEFLQGDWFEPLPSGKFDLIVSNPPYIPEADIHLLDPEVRdFE 180

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 90111419   227 PELGLASGTDGLKLTRRILGNAADYLADDGVLICEVG----NSMVHLMEQYP 274
Cdd:TIGR03534 181 PRLALFGGEDGLDFYRRIIAQAPRLLKPGGWLLLEIGydqgEAVRALFEAAG 232
PRK01544 PRK01544
bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) ...
 37-263 1.19e-28

bifunctional N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase/tRNA (m7G46) methyltransferase; Reviewed


Pssm-ID: 234958 [Multi-domain]  Cd Length: 506  Bit Score: 114.96  E-value: 1.19e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419   37 GTDNPWDEA---VQLVL--PSLYLPLDIPEDMRTARLTSsekhriVERVIRRVNERIPVAYLTNKAWFCGHEFYVDERVL 111
Cdd:PRK01544  20 GISSPQLEArilLQHVInkPIEYLLINLDEQLNEAEIEA------FEKLLERRLKHEPIAYITGVKEFYSREFIVNKHVL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419  112 VPRSPIGELIN------------------NKFAGLIS----KQPQH--ILDMCTGSGCIAIACAYAFPDAEVDAVDISPD 167
Cdd:PRK01544  94 IPRSDTEVLVDvvfqchsresgnpekkqlNPCFRGNDissnCNDKFlnILELGTGSGCIAISLLCELPNANVIATDISLD 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419  168 ALAVAEQNIEEHGLIHNVIPIRSDLFRDLPKVQYDLIVTNPPYVDAEDMSDLPNE-YRHEPELGLASGTDGLKLTRRILG 246
Cdd:PRK01544 174 AIEVAKSNAIKYEVTDRIQIIHSNWFENIEKQKFDFIVSNPPYISHSEKSEMAIEtINYEPSIALFAEEDGLQAYFIIAE 253

                        250
                 ....*....|....*..
gi 90111419  247 NAADYLADDGVLICEVG 263
Cdd:PRK01544 254 NAKQFLKPNGKIILEIG 270
PrmC_rel_meth TIGR03704
putative protein-(glutamine-N5) methyltransferase, unknown substrate-specific; This protein ...
 65-263 3.55e-24

putative protein-(glutamine-N5) methyltransferase, unknown substrate-specific; This protein family is closely related to two different families of protein-(glutamine-N5) methyltransferase. The first is PrmB, which modifies ribosomal protein L3 in some bacteria. The second is PrmC (HemK), which modifies peptide chain release factors 1 and 2 in most bacteria and also in eukaryotes. The glutamine side chain-binding motif NPPY shared by PrmB and PrmC is N[VAT]PY in this family. The protein substrate is unknown. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 274733 [Multi-domain]  Cd Length: 251  Bit Score: 98.32  E-value: 3.55e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419    65 TARlTSSEKHRIVERvirRVNErIPVAYLTNKAWFCGHEFYVDERVLVPRSPIGELINNkfAGLISKQ---PQHILDMCT 141
Cdd:TIGR03704  23 AAR-TPGELAAMVDR---RVAG-LPLEHVLGWAEFCGLRIAVDPGVFVPRRRTEFLVDE--AAALARPrsgTLVVVDLCC 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419   142 GSGCIAIACAYAFPDAEVDAVDISPDALAVAEQNIEEHGL-IHNvipirSDLFRDLPKV---QYDLIVTNPPYVDAEDMS 217
Cdd:TIGR03704  96 GSGAVGAALAAALDGIELHAADIDPAAVRCARRNLADAGGtVHE-----GDLYDALPTAlrgRVDILAANAPYVPTDAIA 170

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 90111419   218 DLPNEYR-HEPELGLASGTDGLKLTRRILGNAADYLADDGVLICEVG 263
Cdd:TIGR03704 171 LMPPEARdHEPRVALDGGADGLDVLRRVAAGAPDWLAPGGHLLVETS 217
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 128-269 7.21e-24

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 96.03  E-value: 7.21e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419 128 LISKQPQHILDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAVAEQNIEEHGLiHNVIPIRSDLFRDLPKVQYDLIVTN 207
Cdd:COG2813  45 LPEPLGGRVLDLGCGYGVIGLALAKRNPEARVTLVDVNARAVELARANAAANGL-ENVEVLWSDGLSGVPDGSFDLILSN 123

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 90111419 208 PPYvdaedmsdlpneyrHepelglASGTDGLKLTRRILGNAADYLADDGVLICeVGNSmvHL 269
Cdd:COG2813 124 PPF--------------H------AGRAVDKEVAHALIADAARHLRPGGELWL-VANR--HL 162
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 131-276 1.06e-22

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 94.06  E-value: 1.06e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419 131 KQPQHILDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAVAEQNIEEHGLIHNVIPIRSDL---FRDLPKVQYDLIVTN 207
Cdd:COG4123  36 KKGGRVLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAELARRNVALNGLEDRITVIHGDLkefAAELPPGSFDLVVSN 115

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 90111419 208 PPYVDAEDMSDLPNEY----RHEPELGLAsgtdglkltrRILGNAADYLADDGVLicevgnSMVHLMEQYPDV 276
Cdd:COG4123 116 PPYFKAGSGRKSPDEAraiaRHEDALTLE----------DLIRAAARLLKPGGRF------ALIHPAERLAEI 172
PRK14966 PRK14966
unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; ...
 82-263 2.35e-22

unknown domain/N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase fusion protein; Provisional


Pssm-ID: 184930 [Multi-domain]  Cd Length: 423  Bit Score: 96.30  E-value: 2.35e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419   82 RRVNERiPVAYLTNKAWFCGHEFYVDERVLVPRSPIGELINnkfaGLISKQPQH--ILDMCTGSGCIAIACAYAFPDAEV 159
Cdd:PRK14966 204 RRLNGE-PVAYILGVREFYGRRFAVNPNVLIPRPETEHLVE----AVLARLPENgrVWDLGTGSGAVAVTVALERPDAFV 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419  160 DAVDISPDALAVAEQNIEEHGLihNVIPIRSDLF-RDLP-KVQYDLIVTNPPYVDAEDMSDLPNEYRHEPELGLASGTDG 237
Cdd:PRK14966 279 RASDISPPALETARKNAADLGA--RVEFAHGSWFdTDMPsEGKWDIIVSNPPYIENGDKHLLQGDLRFEPQIALTDFSDG 356

                        170       180
                 ....*....|....*....|....*.
gi 90111419  238 LKLTRRILGNAADYLADDGVLICEVG 263
Cdd:PRK14966 357 LSCIRTLAQGAPDRLAEGGFLLLEHG 382
PRK14968 PRK14968
putative methyltransferase; Provisional
 128-257 9.80e-20

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 84.95  E-value: 9.80e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419  128 LISKQPQHILDMCTGSGCIAIACAYAfpDAEVDAVDISPDALAVAEQNIEEHGLIHNVIP-IRSDLFRDLPKVQYDLIVT 206
Cdd:PRK14968  19 AVDKKGDRVLEVGTGSGIVAIVAAKN--GKKVVGVDINPYAVECAKCNAKLNNIRNNGVEvIRSDLFEPFRGDKFDVILF 96

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 90111419  207 NPPYvdaedmsdLPNEYRHEP----ELGLASGTDGLKLTRRILGNAADYLADDGV 257
Cdd:PRK14968  97 NPPY--------LPTEEEEEWddwlNYALSGGKDGREVIDRFLDEVGRYLKPGGR 143
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 134-265 9.09e-19

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 81.87  E-value: 9.09e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419   134 QHILDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAVAEQNIEEHGLiHNVIPIRSDLFRDLPKVQYDLIVTNPPYvda 213
Cdd:pfam05175  33 GKVLDLGCGAGVLGAALAKESPDAELTMVDINARALESARENLAANGL-ENGEVVASDVYSGVEDGKFDLIISNPPF--- 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 90111419   214 edmsdlpneyrHEpelGLASGTDglkLTRRILGNAADYLADDGVLICeVGNS 265
Cdd:pfam05175 109 -----------HA---GLATTYN---VAQRFIADAKRHLRPGGELWI-VANR 142
PRK14967 PRK14967
putative methyltransferase; Provisional
 136-259 4.32e-16

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 75.86  E-value: 4.32e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419  136 ILDMCTGSGCIAIACAYAfPDAEVDAVDISPDALAVAEQNIEEHGliHNVIPIRSDLFRDLPKVQYDLIVTNPPYVDAED 215
Cdd:PRK14967  40 VLDLCTGSGALAVAAAAA-GAGSVTAVDISRRAVRSARLNALLAG--VDVDVRRGDWARAVEFRPFDVVVSNPPYVPAPP 116

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 90111419  216 MSdlpneyrhEPELGLA----SGTDGLKLTRRILGNAADYLADDGVLI 259
Cdd:PRK14967 117 DA--------PPSRGPArawdAGPDGRAVLDRLCDAAPALLAPGGSLL 156
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
136-209 9.98e-11

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 59.92  E-value: 9.98e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 90111419 136 ILDMCTGSGCIAIACAYAFPdAEVDAVDISPDALAVAEQNIEEHGLIHNVipIRSDLFRDLPKVQYDLIVTNPP 209
Cdd:COG2263  49 VLDLGCGTGMLAIGAALLGA-KKVVGVDIDPEALEIARENAERLGVRVDF--IRADVTRIPLGGSVDTVVMNPP 119
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 136-262 5.63e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 55.90  E-value: 5.63e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419 136 ILDMCTGSGCIAIAcAYAFPDAEVDAVDISPDALAVAEQNiEEHGLIHNVIPIRSDLFRDLPKV--QYDLIVTNPPYVDA 213
Cdd:cd02440   2 VLDLGCGTGALALA-LASGPGARVTGVDISPVALELARKA-AAALLADNVEVLKGDAEELPPEAdeSFDVIISDPPLHHL 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 90111419 214 EDmsdlpneyrhepelglasgtdglkLTRRILGNAADYLADDGVLICEV 262
Cdd:cd02440  80 VE------------------------DLARFLEEARRLLKPGGVLVLTL 104
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 136-207 1.28e-09

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 54.49  E-value: 1.28e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 90111419   136 ILDMCTGSGCIAIACAYAFpDAEVDAVDISPDALAVAEQNIEEHGLihNVIPIRSDlFRDLPKV--QYDLIVTN 207
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRG-GARVTGVDLSPEMLERARERAAEAGL--NVEFVQGD-AEDLPFPdgSFDLVVSS 70
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 134-205 4.22e-09

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 54.55  E-value: 4.22e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 90111419 134 QHILDMCTGSGCIAIACAYAFpDAEVDAVDISPDALAVAEQNIEEHGLIHNVIPIRSDlFRDLPKV-QYDLIV 205
Cdd:COG2230  53 MRVLDIGCGWGGLALYLARRY-GVRVTGVTLSPEQLEYARERAAEAGLADRVEVRLAD-YRDLPADgQFDAIV 123
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
132-207 1.22e-08

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 51.75  E-value: 1.22e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 90111419 132 QPQHILDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAVAEQNIEehglihNVIPIRSDLFRDLPKVQYDLIVTN 207
Cdd:COG4106   1 PPRRVLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLARARARLP------NVRFVVADLRDLDPPEPFDLVVSN 70
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
131-207 1.24e-08

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 55.18  E-value: 1.24e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 90111419 131 KQPQHILDMCTGSGCIAIACAYAFPdAEVDAVDISPDALAVAEQNIEEHGLIHNVIPIRSDLFRDLPkvqYDLIVTN 207
Cdd:COG2264 147 KPGKTVLDVGCGSGILAIAAAKLGA-KRVLAVDIDPVAVEAARENAELNGVEDRIEVVLGDLLEDGP---YDLVVAN 219
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 136-259 5.32e-08

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 51.87  E-value: 5.32e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419 136 ILDMCTGSGCIAIACAYAfpDAEVDAVDISPDALAVAEQNIEeHGLIHNVIPIRSDlFRDLP--KVQYDLIVTNPPYvda 213
Cdd:COG1041  30 VLDPFCGTGTILIEAGLL--GRRVIGSDIDPKMVEGARENLE-HYGYEDADVIRGD-ARDLPlaDESVDAIVTDPPY--- 102

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 90111419 214 edmsdlpneyrhepelGLASGTDG---LKLTRRILGNAADYLADDGVLI 259
Cdd:COG1041 103 ----------------GRSSKISGeelLELYEKALEEAARVLKPGGRVV 135
CobL COG2242
Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part ...
 134-198 7.59e-08

Precorrin-6B methylase 2 [Coenzyme transport and metabolism]; Precorrin-6B methylase 2 is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 441843 [Multi-domain]  Cd Length: 403  Bit Score: 53.25  E-value: 7.59e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 90111419 134 QHILDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAVAEQNIEEHGLiHNVIPIR---SDLFRDLPK 198
Cdd:COG2242 249 DVLWDIGAGSGSVSIEAARLAPGGRVYAIERDPERAALIRANARRFGV-PNVEVVEgeaPEALADLPD 315
Trm5 COG2520
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
 101-210 7.66e-08

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 52.94  E-value: 7.66e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419 101 GHEFYVD-ERVLVprSP--------IGELInnkfaglisKQPQHILDMCTGSGCIAIACAyAFPDAEVDAVDISPDALAV 171
Cdd:COG2520 151 GCRFKLDvAKVYF--SPrlaterlrIAELV---------KPGERVLDMFAGVGPFSIPIA-KRSGAKVVAIDINPDAVEY 218

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 90111419 172 AEQNIEEHGLIHNVIPIRSDlFRDLP---KVQYDLIVTNPPY 210
Cdd:COG2520 219 LKENIRLNKVEDRVTPILGD-AREVApelEGKADRIIMNLPH 259
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
131-207 5.27e-07

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 49.77  E-value: 5.27e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 90111419  131 KQPQHILDMCTGSGCIAIACAY--AfpdAEVDAVDISPDALAVAEQNIEEHGLIHNVipirsDLFRDLPKvqYDLIVTN 207
Cdd:PRK00517 118 LPGKTVLDVGCGSGILAIAAAKlgA---KKVLAVDIDPQAVEAARENAELNGVELNV-----YLPQGDLK--ADVIVAN 186
rsmC PRK09489
16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;
135-217 2.02e-06

16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC;


Pssm-ID: 181902 [Multi-domain]  Cd Length: 342  Bit Score: 48.78  E-value: 2.02e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419  135 HILDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAVAEQNIEEHGLIHNVIPirSDLFRDLPKvQYDLIVTNPPYVDAE 214
Cdd:PRK09489 199 KVLDVGCGAGVLSAVLARHSPKIRLTLSDVSAAALESSRATLAANGLEGEVFA--SNVFSDIKG-RFDMIISNPPFHDGI 275


                 ...
gi 90111419  215 DMS 217
Cdd:PRK09489 276 QTS 278
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 125-207 2.03e-06

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 46.53  E-value: 2.03e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419 125 FAGLISKQPQHILDMCTGSGciAIACAYAFPDAEVDAVDISPDALAVAEQNIEEHGLihNVIPIRSDLFR-DLPKVQYDL 203
Cdd:COG2226  15 LAALGLRPGARVLDLGCGTG--RLALALAERGARVTGVDISPEMLELARERAAEAGL--NVEFVVGDAEDlPFPDGSFDL 90


                ....
gi 90111419 204 IVTN 207
Cdd:COG2226  91 VISS 94
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 132-264 2.35e-06

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 46.16  E-value: 2.35e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419 132 QPQHILDMCTGSGCIAIACAYAFpdAEVDAVDISPDALAVAEQNIEEhgliHNVIPIRSDLFR-DLPKVQYDLIVTNppY 210
Cdd:COG2227  24 AGGRVLDVGCGTGRLALALARRG--ADVTGVDISPEALEIARERAAE----LNVDFVQGDLEDlPLEDGSFDLVICS--E 95

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 90111419 211 VdaedmsdLpnEYRHEPElglasgtdglkltrRILGNAADYLADDGVLICEVGN 264
Cdd:COG2227  96 V-------L--EHLPDPA--------------ALLRELARLLKPGGLLLLSTPN 126
PRK08287 PRK08287
decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;
135-185 2.70e-06

decarboxylating cobalt-precorrin-6B (C(15))-methyltransferase;


Pssm-ID: 181354  Cd Length: 187  Bit Score: 46.92  E-value: 2.70e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 90111419  135 HILDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAVAEQNIEEHGLiHNV 185
Cdd:PRK08287  34 HLIDVGAGTGSVSIEAALQFPSLQVTAIERNPDALRLIKENRQRFGC-GNI 83
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 157-209 3.22e-06

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 48.25  E-value: 3.22e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 90111419 157 AEVDAVDISPDALAVAEQNIEEHGLIHNVIPIRSDLF---RDLPKV--QYDLIVTNPP 209
Cdd:COG1092 240 KSVTSVDLSATALEWAKENAALNGLDDRHEFVQADAFdwlRELAREgeRFDLIILDPP 297
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 137-207 3.94e-06

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 44.67  E-value: 3.94e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 90111419   137 LDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAVAEQNIEEHGLIHNV---IPIRSDLFRDLPKvqYDLIVTN 207
Cdd:pfam08242   1 LEIGCGTGTLLRALLEALPGLEYTGLDISPAALEAARERLAALGLLNAVrveLFQLDLGELDPGS--FDVVVAS 72
RlmL COG0116
23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA ...
 163-210 4.23e-06

23S rRNA G2445 N2-methylase RlmL [Translation, ribosomal structure and biogenesis]; 23S rRNA G2445 N2-methylase RlmL is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 439886 [Multi-domain]  Cd Length: 369  Bit Score: 47.79  E-value: 4.23e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 90111419 163 DISPDALAVAEQNIEEHGLIHNVIPIRSDlFRDL-PKVQYDLIVTNPPY 210
Cdd:COG0116 257 DIDPRAIEAARENAERAGVADLIEFEQAD-FRDLePPAEPGLIITNPPY 304
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 131-205 7.11e-06

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 46.06  E-value: 7.11e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 90111419 131 KQPQHILDMCTGSGCIAIACAYAFpDAEVDAVDISPDALAVAEQNIEEHGLiHNVIPIRSDL--FRDLPKVQYDLIV 205
Cdd:COG0500  25 PKGGRVLDLGCGTGRNLLALAARF-GGRVIGIDLSPEAIALARARAAKAGL-GNVEFLVADLaeLDPLPAESFDLVV 99
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 135-207 9.29e-06

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 44.72  E-value: 9.29e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 90111419   135 HILDMCTGSGCIAIACAY-AFPDAEVDAVDISPDALAVAEQNIEEHGLIhNVIPIRSDLFrDLPKV----QYDLIVTN 207
Cdd:pfam13847   6 RVLDLGCGTGHLSFELAEeLGPNAEVVGIDISEEAIEKARENAQKLGFD-NVEFEQGDIE-ELPELleddKFDVVISN 81
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 136-207 1.03e-05

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 46.10  E-value: 1.03e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 90111419   136 ILDMCTGSGCIAIACAYaFPDAEVDAVDISPDALAVAEQNIEEHGlIHNVIPIRsdLFRDLPKVQYDLIVTN 207
Cdd:pfam06325 165 VLDVGCGSGILAIAALK-LGAKKVVGVDIDPVAVRAAKENAELNG-VEARLEVY--LPGDLPKEKADVVVAN 232
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 130-185 1.51e-05

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 45.53  E-value: 1.51e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 90111419  130 SKQPQHILDMCTGSGCIAIA-CAYAFPDAEVDAVDISPDALAVAEQNIEEHGLIHNV 185
Cdd:PRK00216  49 VRPGDKVLDLACGTGDLAIAlAKAVGKTGEVVGLDFSEGMLAVGREKLRDLGLSGNV 105
UPF0020 pfam01170
Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated ...
 136-210 2.44e-04

Putative RNA methylase family UPF0020; This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.


Pssm-ID: 395932 [Multi-domain]  Cd Length: 184  Bit Score: 41.19  E-value: 2.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419   136 ILD-MCtGSGCIAIA-------CAYAFPDAEVDA----VDISPDALAVAEQNIEEHGLIHnVIPIRSDLFRDLP--KVQY 201
Cdd:pfam01170  32 LLDpMC-GSGTILIEaalmganIAPGKFDARVRAplygSDIDRRMVQGARLNAENAGVGD-LIEFVQADAADLPllEGSV 109


                  ....*....
gi 90111419   202 DLIVTNPPY 210
Cdd:pfam01170 110 DVIVTNPPY 118
Met_10 pfam02475
Met-10+ like-protein; The methionine-10 mutant allele of N. crassa codes for a protein of ...
 136-210 3.06e-04

Met-10+ like-protein; The methionine-10 mutant allele of N. crassa codes for a protein of unknown function, Swiss:O27901. However, homologous proteins have been found in yeast suggesting this protein may be involved in methionine biosynthesis, transport and/or utilization.


Pssm-ID: 396850 [Multi-domain]  Cd Length: 198  Bit Score: 41.18  E-value: 3.06e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 90111419   136 ILDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAVAEQNIEEHGLIHNVIPIRSDLFRDLPKVQYDLIVTNPPY 210
Cdd:pfam02475 103 VVDMFAGIGPFSIPIAKHSKARRVYAIELNPESYKYLKENIKLNKVEDVVKPILGDVREVILEDVADRVVMNLPG 177
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
125-262 3.22e-04

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 40.75  E-value: 3.22e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419 125 FAGLISKQPQHILDMCTGSGciaiACAYAFPDA--EVDAVDISPDALAVAEQNIEEHGLIHnvipirSDlFRDLPKV--Q 200
Cdd:COG4976  39 LARLPPGPFGRVLDLGCGTG----LLGEALRPRgyRLTGVDLSEEMLAKAREKGVYDRLLV------AD-LADLAEPdgR 107

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 90111419 201 YDLIVtnppyvdaedMSD-LPneYRHEPElglasgtdglkltrRILGNAADYLADDGVLICEV 262
Cdd:COG4976 108 FDLIV----------AADvLT--YLGDLA--------------AVFAGVARALKPGGLFIFSV 144
rlmL PRK11783
bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2)) ...
 163-210 3.34e-04

bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL;


Pssm-ID: 236981 [Multi-domain]  Cd Length: 702  Bit Score: 42.10  E-value: 3.34e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 90111419  163 DISPDALAVAEQNIEEHGLiHNVIPIR----SDLFRDLPKVQYDLIVTNPPY 210
Cdd:PRK11783 263 DIDPRVIQAARKNARRAGV-AELITFEvkdvADLKNPLPKGPTGLVISNPPY 313
N6_Mtase pfam02384
N-6 DNA Methylase; Restriction-modification (R-M) systems protect a bacterial cell against ...
 101-232 4.68e-04

N-6 DNA Methylase; Restriction-modification (R-M) systems protect a bacterial cell against invasion of foreign DNA by endonucleolytic cleavage of DNA that lacks a site specific modification. The R-M system is a complex containing three polypeptides: M (this family), S (pfam01420), and R. This family consists of N-6 adenine-specific DNA methylase EC:2.1.1.72 from Type I and Type IC restriction systems. These methylases have the same sequence specificity as their corresponding restriction enzymes.


Pssm-ID: 426749 [Multi-domain]  Cd Length: 310  Bit Score: 41.15  E-value: 4.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419   101 GHEFYVdervlvPRSpIGELINNKfagLISKQPQHILDMCTGSGCIAIaCAYAFPDAEVD--------AVDISPDALAVA 172
Cdd:pfam02384  24 GGEFFT------PRE-VSKLIVEL---LDPKPGESIYDPACGSGGFLI-QAEKFVKEHDGdtndlsiyGQEKNPTTYRLA 92

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 90111419   173 EQNIEEHGLIHNVIPIR------SDLFRDLPKVqyDLIVTNPPYVDAEDMSD-LPNEYRHEPELGLA 232
Cdd:pfam02384  93 RMNMILHGIEYDDFHIRhgdtltSPKFEDDKKF--DVVVANPPFSDKWDANDtLENDPRFRPAYGVA 157
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
134-206 4.72e-04

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 40.79  E-value: 4.72e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 90111419 134 QHILDMCTGSGCIAIACAYAFPDaEVDAVDISPDALAVAEQNIEEHGLIHNVIPIRSDLFRDLPKVQYDLIVT 206
Cdd:COG4076  37 DVVLDIGTGSGLLSMLAARAGAK-KVYAVEVNPDIAAVARRIIAANGLSDRITVINADATDLDLPEKADVIIS 108
Ubie_methyltran pfam01209
ubiE/COQ5 methyltransferase family;
131-182 4.79e-04

ubiE/COQ5 methyltransferase family;


Pssm-ID: 395966 [Multi-domain]  Cd Length: 228  Bit Score: 40.89  E-value: 4.79e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 90111419   131 KQPQHILDMCTGSGCIAIACA-YAFPDAEVDAVDISPDALAVAEQNIEEHGLI 182
Cdd:pfam01209  41 KRGNKFLDVAGGTGDWTFGLSdSAGSSGKVVGLDINENMLKEGEKKAKEEGKY 93
COG2521 COG2521
Predicted archaeal methyltransferase [General function prediction only];
135-209 6.36e-04

Predicted archaeal methyltransferase [General function prediction only];


Pssm-ID: 442011 [Multi-domain]  Cd Length: 285  Bit Score: 40.66  E-value: 6.36e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 90111419 135 HILDMCTGSGCIAIACAyAFPDAEVDAVDISPDALAVAEQNIEEHGLIHNVIPIR----SDLFRDLPKVQYDLIVTNPP 209
Cdd:COG2521 135 RVLDTCTGLGYTAIEAL-KRGAREVITVEKDPNVLELAELNPWSRELANERIKIIlgdaSEVIKTFPDESFDAIIHDPP 212
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 132-207 1.04e-03

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 39.96  E-value: 1.04e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 90111419   132 QPQHILDMCTGSGCIAIACAYAFPDAEVDAVDISPDALAVAEQNIEEHglihnVIPIRSDLFR-DLPKVQYDLIVTN 207
Cdd:TIGR02072  34 IPASVLDIGCGTGYLTRALLKRFPQAEFIALDISAGMLAQAKTKLSEN-----VQFICGDAEKlPLEDSSFDLIVSN 105
Cons_hypoth95 pfam03602
Conserved hypothetical protein 95;
135-210 1.07e-03

Conserved hypothetical protein 95;


Pssm-ID: 427391 [Multi-domain]  Cd Length: 179  Bit Score: 39.14  E-value: 1.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111419   135 HILDMCTGSGCIAI--ACAYAfpdAEVDAVDISPDALAVAEQNIEEHGLihNVIPIRSDLFRDLPK-----VQYDLIVTN 207
Cdd:pfam03602  44 RVLDLFAGSGALGLeaLSRGA---KRVTLVEKDKRAVQILKENLQLLGL--PGAVLVMDALLALLRlagkgPVFDIVFLD 118


                  ...
gi 90111419   208 PPY 210
Cdd:pfam03602 119 PPY 121
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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