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Conserved domains on  [gi|16130314|ref|NP_416883|]
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putative AraC-type DNA-binding transcriptional regulator YpdC [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

AraC family transcriptional regulator( domain architecture ID 13303782)

AraC family transcriptional regulator controls the expression of genes with diverse biological functions including metabolism, stress response, and virulence

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
197-279 2.52e-30

helix_turn_helix, arabinose operon control protein;


:

Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 109.18  E-value: 2.52e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130314    197 PLTRESVAQFFNITPNHLSKLFAQHGTMRFIEYVRWVRMAKARMILQKYHLSIHEVAQRCGFPDSDYFCRVFRRQFGLTP 276
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ...
gi 16130314    277 GEY 279
Cdd:smart00342  81 SEY 83
PRK13502 super family cl32883
HTH-type transcriptional activator RhaR;
47-279 5.78e-16

HTH-type transcriptional activator RhaR;


The actual alignment was detected with superfamily member PRK13502:

Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 75.86  E-value: 5.78e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130314   47 DFPRLDIVLRGEYGNLLEAKQQRLVEGEMLFIPARAANLPVNNKPVMLLSLVFAPTWLGL-----SFYDSRTTSLLHPar 121
Cdd:PRK13502  37 EFCELVMVWRGNGLHVLNERPYRITRGDLFYIRAEDKHSYTSVNDLVLQNIIYCPERLKLnvnwqAMIPGFQGAQWHP-- 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130314  122 QIQLPSLQRGEGEAMLTALTHLS--RSPLEQNIIQ----PLVLSLLHLCRSVVNMPPGNSQPRGDFLYHSICNWVQdnya 195
Cdd:PRK13502 115 HWRLGSMGMNQARQVINQLEHESngRDPLANEMAEllfgQLVMTLKRHRYATDDLPATSRETLLDKLITALANSLE---- 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130314  196 QPLTRESVAQFFNITPNHLSKLFAQHGTMRFIEYVRWVRMAKARMILQKYHLSIHEVAQRCGFPDSDYFCRVFRRQFGLT 275
Cdd:PRK13502 191 CPFALDAFCQQEQCSERVLRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCGFEDSNYFSVVFTRETGMT 270


                 ....
gi 16130314  276 PGEY 279
Cdd:PRK13502 271 PSQW 274
 
Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
197-279 2.52e-30

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 109.18  E-value: 2.52e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130314    197 PLTRESVAQFFNITPNHLSKLFAQHGTMRFIEYVRWVRMAKARMILQKYHLSIHEVAQRCGFPDSDYFCRVFRRQFGLTP 276
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ...
gi 16130314    277 GEY 279
Cdd:smart00342  81 SEY 83
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 189-285 1.08e-22

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 95.22  E-value: 1.08e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130314 189 WVQDNYAQPLTRESVAQFFNITPNHLSKLFAQHGTMRFIEYVRWVRMAKARMILQKYHLSIHEVAQRCGFPDSDYFCRVF 268
Cdd:COG4977 218 WMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFGSASHFRRAF 297

                        90
                ....*....|....*..
gi 16130314 269 RRQFGLTPGEYSARFQG 285
Cdd:COG4977 298 RRRFGVSPSAYRRRFRA 314
HTH_18 pfam12833
Helix-turn-helix domain;
203-282 1.82e-19

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 80.71  E-value: 1.82e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130314   203 VAQFFNITPNHLSKLFAQHGTMRFIEYVRWVRMAKAR-MILQKYHLSIHEVAQRCGFPDSDYFCRVFRRQFGLTPGEYSA 281
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARrLLLEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 16130314   282 R 282
Cdd:pfam12833  81 R 81
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
47-279 5.78e-16

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 75.86  E-value: 5.78e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130314   47 DFPRLDIVLRGEYGNLLEAKQQRLVEGEMLFIPARAANLPVNNKPVMLLSLVFAPTWLGL-----SFYDSRTTSLLHPar 121
Cdd:PRK13502  37 EFCELVMVWRGNGLHVLNERPYRITRGDLFYIRAEDKHSYTSVNDLVLQNIIYCPERLKLnvnwqAMIPGFQGAQWHP-- 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130314  122 QIQLPSLQRGEGEAMLTALTHLS--RSPLEQNIIQ----PLVLSLLHLCRSVVNMPPGNSQPRGDFLYHSICNWVQdnya 195
Cdd:PRK13502 115 HWRLGSMGMNQARQVINQLEHESngRDPLANEMAEllfgQLVMTLKRHRYATDDLPATSRETLLDKLITALANSLE---- 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130314  196 QPLTRESVAQFFNITPNHLSKLFAQHGTMRFIEYVRWVRMAKARMILQKYHLSIHEVAQRCGFPDSDYFCRVFRRQFGLT 275
Cdd:PRK13502 191 CPFALDAFCQQEQCSERVLRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCGFEDSNYFSVVFTRETGMT 270


                 ....
gi 16130314  276 PGEY 279
Cdd:PRK13502 271 PSQW 274
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
172-282 1.17e-15

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 75.40  E-value: 1.17e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130314  172 PGNSQPRGDFLYHSICNWVQDNYAQPLTRESVAQFFNITPNHLSKLFAQH-GtmrfIEYVRW---VRMAKARMILQKYHL 247
Cdd:PRK10572 174 PESLHPPMDPRVREACQYISDHLASEFDIESVAQHVCLSPSRLAHLFRQQlG----ISVLRWredQRISRAKLLLQTTRM 249

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 16130314  248 SIHEVAQRCGFPDSDYFCRVFRRQFGLTPGEYSAR 282
Cdd:PRK10572 250 PIATIGRNVGYDDQLYFSRVFKKCTGASPSEFRAR 284
 
Name Accession Description Interval E-value
HTH_ARAC smart00342
helix_turn_helix, arabinose operon control protein;
197-279 2.52e-30

helix_turn_helix, arabinose operon control protein;


Pssm-ID: 197666 [Multi-domain]  Cd Length: 84  Bit Score: 109.18  E-value: 2.52e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130314    197 PLTRESVAQFFNITPNHLSKLFAQHGTMRFIEYVRWVRMAKARMILQKYHLSIHEVAQRCGFPDSDYFCRVFRRQFGLTP 276
Cdd:smart00342   1 PLTLEDLAEALGVSPRHLQRLFKKETGTTPKQYLRDRRLERARRLLRDTDLSVTEIALRVGFSSQSYFSRAFKKLFGVTP 80


                   ...
gi 16130314    277 GEY 279
Cdd:smart00342  81 SEY 83
GlxA COG4977
Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH ...
 189-285 1.08e-22

Transcriptional regulator GlxA, contains an amidase domain and an AraC-type DNA-binding HTH domain [Transcription];


Pssm-ID: 444002 [Multi-domain]  Cd Length: 318  Bit Score: 95.22  E-value: 1.08e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130314 189 WVQDNYAQPLTRESVAQFFNITPNHLSKLFAQHGTMRFIEYVRWVRMAKARMILQKYHLSIHEVAQRCGFPDSDYFCRVF 268
Cdd:COG4977 218 WMEANLEEPLSVDELARRAGMSPRTLERRFRAATGTTPARYLQRLRLERARRLLETTDLSIEEIAAACGFGSASHFRRAF 297

                        90
                ....*....|....*..
gi 16130314 269 RRQFGLTPGEYSARFQG 285
Cdd:COG4977 298 RRRFGVSPSAYRRRFRA 314
AraC COG2207
AraC-type DNA-binding domain and AraC-containing proteins [Transcription];
198-284 4.49e-20

AraC-type DNA-binding domain and AraC-containing proteins [Transcription];


Pssm-ID: 441809 [Multi-domain]  Cd Length: 258  Bit Score: 87.14  E-value: 4.49e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130314 198 LTRESVAQFFNITPNHLSKLFAQHGTMRFIEYVRWVRMAKARMILQKYHLSIHEVAQRCGFPDSDYFCRVFRRQFGLTPG 277
Cdd:COG2207 169 LTLEELARELGLSPRTLSRLFKEETGTSPKQYLRELRLERAKRLLAETDLSISEIAYELGFSSQSHFSRAFKKRFGVTPS 248


                ....*..
gi 16130314 278 EYSARFQ 284
Cdd:COG2207 249 EYRKRLR 255
HTH_18 pfam12833
Helix-turn-helix domain;
203-282 1.82e-19

Helix-turn-helix domain;


Pssm-ID: 432818 [Multi-domain]  Cd Length: 81  Bit Score: 80.71  E-value: 1.82e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130314   203 VAQFFNITPNHLSKLFAQHGTMRFIEYVRWVRMAKAR-MILQKYHLSIHEVAQRCGFPDSDYFCRVFRRQFGLTPGEYSA 281
Cdd:pfam12833   1 LAAALGMSPRTLSRLFKRELGLSPKEYLRRLRLERARrLLLEDTGLSVAEIALALGFSDASHFSRAFRRLFGLTPSEYRR 80


                  .
gi 16130314   282 R 282
Cdd:pfam12833  81 R 81
PRK13502 PRK13502
HTH-type transcriptional activator RhaR;
47-279 5.78e-16

HTH-type transcriptional activator RhaR;


Pssm-ID: 184093 [Multi-domain]  Cd Length: 282  Bit Score: 75.86  E-value: 5.78e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130314   47 DFPRLDIVLRGEYGNLLEAKQQRLVEGEMLFIPARAANLPVNNKPVMLLSLVFAPTWLGL-----SFYDSRTTSLLHPar 121
Cdd:PRK13502  37 EFCELVMVWRGNGLHVLNERPYRITRGDLFYIRAEDKHSYTSVNDLVLQNIIYCPERLKLnvnwqAMIPGFQGAQWHP-- 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130314  122 QIQLPSLQRGEGEAMLTALTHLS--RSPLEQNIIQ----PLVLSLLHLCRSVVNMPPGNSQPRGDFLYHSICNWVQdnya 195
Cdd:PRK13502 115 HWRLGSMGMNQARQVINQLEHESngRDPLANEMAEllfgQLVMTLKRHRYATDDLPATSRETLLDKLITALANSLE---- 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130314  196 QPLTRESVAQFFNITPNHLSKLFAQHGTMRFIEYVRWVRMAKARMILQKYHLSIHEVAQRCGFPDSDYFCRVFRRQFGLT 275
Cdd:PRK13502 191 CPFALDAFCQQEQCSERVLRQQFRAQTGMTINQYLRQVRICHAQYLLQHSPLMISEISMQCGFEDSNYFSVVFTRETGMT 270


                 ....
gi 16130314  276 PGEY 279
Cdd:PRK13502 271 PSQW 274
PRK10572 PRK10572
arabinose operon transcriptional regulator AraC;
172-282 1.17e-15

arabinose operon transcriptional regulator AraC;


Pssm-ID: 236717 [Multi-domain]  Cd Length: 290  Bit Score: 75.40  E-value: 1.17e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130314  172 PGNSQPRGDFLYHSICNWVQDNYAQPLTRESVAQFFNITPNHLSKLFAQH-GtmrfIEYVRW---VRMAKARMILQKYHL 247
Cdd:PRK10572 174 PESLHPPMDPRVREACQYISDHLASEFDIESVAQHVCLSPSRLAHLFRQQlG----ISVLRWredQRISRAKLLLQTTRM 249

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 16130314  248 SIHEVAQRCGFPDSDYFCRVFRRQFGLTPGEYSAR 282
Cdd:PRK10572 250 PIATIGRNVGYDDQLYFSRVFKKCTGASPSEFRAR 284
PRK13503 PRK13503
HTH-type transcriptional activator RhaS;
156-278 5.41e-13

HTH-type transcriptional activator RhaS;


Pssm-ID: 184094 [Multi-domain]  Cd Length: 278  Bit Score: 67.39  E-value: 5.41e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130314  156 LVLSLLHLCRSVVNMPPGNSQprgDFLYHSICNWVQDNYAQPLTRESVAQFFNITPNHLSKLFAQHGTMRFIEYVRWVRM 235
Cdd:PRK13503 149 LFMQLLVLLRKSSLQENGENS---DARLNQLLAWLEDHFAEEVNWEALADQFSLSLRTLHRQLKQQTGLTPQRYLNRLRL 225

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 16130314  236 AKARMILQKYHLSIHEVAQRCGFPDSDYFCRVFRRQFGLTPGE 278
Cdd:PRK13503 226 LKARHLLRHSDASVTDIAYRCGFGDSNHFSTLFRREFSWSPRD 268
PRK13500 PRK13500
HTH-type transcriptional activator RhaR;
47-279 1.48e-12

HTH-type transcriptional activator RhaR;


Pssm-ID: 184091 [Multi-domain]  Cd Length: 312  Bit Score: 66.66  E-value: 1.48e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130314   47 DFPRLDIVLRGEYGNLLEAKQQRLVEGEMLFIPARAANLPVNNKPVMLLSLVFAPTWLGLSF-YDSRTTSLLHPARQ--I 123
Cdd:PRK13500  67 DFCELVIVWRGNGLHVLNDRPYRITRGDLFYIHADDKHSYASVNDLVLQNIIYCPERLKLNLdWQGAIPGFSASAGQphW 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130314  124 QLPSLQRGEGEAMLTALTHLSRS--PLEQNIIQPLVLSLLHLCR----SVVNMPPGNSQPrgdfLYHSICNWVQDNYAQP 197
Cdd:PRK13500 147 RLGSVGMAQARQVIGQLEHESSQhvPFANEMAELLFGQLVMLLNrhryTSDSLPPTSSET----LLDKLITRLAASLKSP 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130314  198 LTRESVAQFFNITPNHLSKLFAQHGTMRFIEYVRWVRMAKARMILQKYHLSIHEVAQRCGFPDSDYFCRVFRRQFGLTPG 277
Cdd:PRK13500 223 FALDKFCDEASCSERVLRQQFRQQTGMTINQYLRQVRVCHAQYLLQHSRLLISDISTECGFEDSNYFSVVFTRETGMTPS 302


                 ..
gi 16130314  278 EY 279
Cdd:PRK13500 303 QW 304
PRK13501 PRK13501
HTH-type transcriptional activator RhaR;
214-283 3.21e-12

HTH-type transcriptional activator RhaR;


Pssm-ID: 184092 [Multi-domain]  Cd Length: 290  Bit Score: 65.31  E-value: 3.21e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130314  214 LSKLFAQHGTMRFIEYVRWVRMAKARMILQKYHLSIHEVAQRCGFPDSDYFCRVFRRQFGLTPGEYSARF 283
Cdd:PRK13501 209 LKQLFRQQTGMSISHYLRQIRLCHAKCLLRGSEHRISDIAARCGFEDSNYFSAVFTREAGMTPRDYRQRF 278
AdaA COG2169
Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), ...
 186-282 8.31e-12

Methylphosphotriester-DNA--protein-cysteine methyltransferase (N-terminal fragment of Ada), contains Zn-binding and two AraC-type DNA-binding domains [Replication, recombination and repair];


Pssm-ID: 441772 [Multi-domain]  Cd Length: 358  Bit Score: 64.69  E-value: 8.31e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130314 186 ICNWVQDNYAQPLTRESVAQFFNITPNHLSKLFAQHGTMRFIEYVRWVRMAKARMILQKyHLSIHEVAQRCGFPDSDYFC 265
Cdd:COG2169  89 ACRLIEAGAEDRPSLEDLAARLGLSPRHLRRLFKAHTGVTPKAYARARRLLRARQLLQT-GLSVTDAAYAAGFGSLSRFY 167

                        90
                ....*....|....*..
gi 16130314 266 RVFRRQFGLTPGEYSAR 282
Cdd:COG2169 168 EAFKKLLGMTPSAYRRG 184
PRK09685 PRK09685
DNA-binding transcriptional activator FeaR; Provisional
 132-284 5.21e-11

DNA-binding transcriptional activator FeaR; Provisional


Pssm-ID: 236612 [Multi-domain]  Cd Length: 302  Bit Score: 61.97  E-value: 5.21e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130314  132 EGEAMLTALTHLSRSPLEQNiiqplvlsllhlcrsvvnmppGNSQPRGDFLYHSICNWVQDNYAQP-LTRESVAQFFNIT 210
Cdd:PRK09685 169 ESEALLEALIALLRPALHQR---------------------ESVQPRRERQFQKVVALIDQSIQEEiLRPEWIAGELGIS 227

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16130314  211 PNHLSKLFAQHG--TMRFIEYVRWVRMAKArmiLQKYHL--SIHEVAQRCGFPDSDYFCRVFRRQFGLTPGEYSARFQ 284
Cdd:PRK09685 228 VRSLYRLFAEQGlvVAQYIRNRRLDRCADD---LRPAADdeKITSIAYKWGFSDSSHFSTAFKQRFGVSPGEYRRKFR 302
ftrA PRK09393
transcriptional activator FtrA; Provisional
 170-283 2.64e-10

transcriptional activator FtrA; Provisional


Pssm-ID: 181818 [Multi-domain]  Cd Length: 322  Bit Score: 59.98  E-value: 2.64e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130314  170 MPPGNSQPRGDFLyhsicNWVQDNYAQPLTRESVAQFFNITPNHLSKLFAQHGTMRFIEYVRWVRMAKARMILQKYHLSI 249
Cdd:PRK09393 212 VASRESDRLGPLI-----DWMRAHLAEPHTVASLAARAAMSPRTFLRRFEAATGMTPAEWLLRERLARARDLLESSALSI 286

                         90       100       110
                 ....*....|....*....|....*....|....
gi 16130314  250 HEVAQRCGFPDSDYFCRVFRRQFGLTPGEYSARF 283
Cdd:PRK09393 287 DQIAERAGFGSEESLRHHFRRRAATSPAAYRKRF 320
PRK10219 PRK10219
superoxide response transcriptional regulator SoxS;
184-279 4.32e-10

superoxide response transcriptional regulator SoxS;


Pssm-ID: 182314 [Multi-domain]  Cd Length: 107  Bit Score: 56.09  E-value: 4.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130314  184 HSICNWVQDNYAQPLTRESVAQFFNITPNHLSKLFAQHGTMRFIEYVRWVRMAKARMILQKYHLSIHEVAQRCGFPDSDY 263
Cdd:PRK10219   8 QTLIAWIDEHIDQPLNIDVVAKKSGYSKWYLQRMFRTVTHQTLGDYIRQRRLLLAAVELRTTERPIFDIAMDLGYVSQQT 87

                         90
                 ....*....|....*.
gi 16130314  264 FCRVFRRQFGLTPGEY 279
Cdd:PRK10219  88 FSRVFRRQFDRTPSDY 103
PRK11511 PRK11511
MDR efflux pump AcrAB transcriptional activator MarA;
184-279 6.85e-10

MDR efflux pump AcrAB transcriptional activator MarA;


Pssm-ID: 236920 [Multi-domain]  Cd Length: 127  Bit Score: 55.88  E-value: 6.85e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130314  184 HSICNWVQDNYAQPLTRESVAQFFNITPNHLSKLFAQHGTMRFIEYVRWVRMAKARMILQKYHLSIHEVAQRCGFPDSDY 263
Cdd:PRK11511  12 HSILDWIEDNLESPLSLEKVSERSGYSKWHLQRMFKKETGHSLGQYIRSRKMTEIAQKLKESNEPILYLAERYGFESQQT 91

                         90
                 ....*....|....*.
gi 16130314  264 FCRVFRRQFGLTPGEY 279
Cdd:PRK11511  92 LTRTFKNYFDVPPHKY 107
PRK09978 PRK09978
DNA-binding transcriptional regulator GadX; Provisional
 186-284 2.20e-08

DNA-binding transcriptional regulator GadX; Provisional


Pssm-ID: 137624 [Multi-domain]  Cd Length: 274  Bit Score: 54.16  E-value: 2.20e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130314  186 ICNWVQDNYAQPLTRESVAQFFNITPNHLSKLFAQHGTmRFIEYVRWVRMAKARMILQKYHLSIHEVAQRCGFPDSDYFC 265
Cdd:PRK09978 147 VCTVINNNIAHEWTLARIASELLMSPSLLKKKLREEET-SYSQLLTECRMQRALQLIVIHGFSIKRVAVSCGYHSVSYFI 225

                         90
                 ....*....|....*....
gi 16130314  266 RVFRRQFGLTPGEYSARFQ 284
Cdd:PRK09978 226 YVFRNYYGMTPTEYQERSA 244
HTH_AraC pfam00165
Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the ...
 241-279 1.31e-06

Bacterial regulatory helix-turn-helix proteins, AraC family; In the absence of arabinose, the N-terminal arm of AraC binds to the DNA binding domain (pfam00165) and helps to hold the two DNA binding domains in a relative orientation that favours DNA looping. In the presence of arabinose, the arms bind over the arabinose on the dimerization domain, thus freeing the DNA-binding domains. The freed DNA-binding domains are then able to assume a conformation suitable for binding to the adjacent DNA sites that are utilized when AraC activates transcription, and hence AraC ceases looping the DNA when arabinose is added.


Pssm-ID: 425497 [Multi-domain]  Cd Length: 42  Bit Score: 44.45  E-value: 1.31e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 16130314   241 ILQKYH--LSIHEVAQRCGFpDSDYFCRVFRRQFGLTPGEY 279
Cdd:pfam00165   1 LRENLStnLTIADIADELGF-SRSYFSRLFKKYTGVTPSQY 40
PRK10371 PRK10371
transcriptional regulator MelR;
189-279 1.22e-05

transcriptional regulator MelR;


Pssm-ID: 182416 [Multi-domain]  Cd Length: 302  Bit Score: 45.97  E-value: 1.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130314  189 WVQDNYAQPLTRESVAQFFNITPNHLSKLFAQHGTMRFIEYVRWVRMAKARMILQKYHLSIHEVAQRCGFPDSDYFCRVF 268
Cdd:PRK10371 199 FIAENYDQALTINDVAEHVKLNANYAMGIFQRVMQLTMKQYITAMRINHVRALLSDTDKSILDIALTAGFRSSSRFYSTF 278

                         90
                 ....*....|.
gi 16130314  269 RRQFGLTPGEY 279
Cdd:PRK10371 279 GKYVGMSPQQY 289
PRK15186 PRK15186
AraC family transcriptional regulator; Provisional
 182-284 9.92e-05

AraC family transcriptional regulator; Provisional


Pssm-ID: 185108 [Multi-domain]  Cd Length: 291  Bit Score: 43.13  E-value: 9.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130314  182 LYHSICNWVQDNYAQPLTRESVAQFFNITPNHLSKLFAQHGTmRFIEYVRWVRMAKARMILQKYHLSIHEVAQRCGFPDS 261
Cdd:PRK15186 182 LAENIYNIIISDISRKWALKDISDSLYMSCSTLKRKLKQENT-SFSEVYLNARMNKATKLLRNSEYNITRVAYMCGYDSA 260

                         90       100
                 ....*....|....*....|....*...
gi 16130314  262 DYFCRVFRRQFGLTPGEY-----SARFQ 284
Cdd:PRK15186 261 SYFTCVFKKHFKTTPSEFlaflsSSRHQ 288
PRK09940 PRK09940
transcriptional regulator YdeO; Provisional
 188-284 1.58e-04

transcriptional regulator YdeO; Provisional


Pssm-ID: 182157 [Multi-domain]  Cd Length: 253  Bit Score: 42.38  E-value: 1.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130314  188 NWVQDNYAQPLTRESVAQFFNITPNHLSKLFAQHGTMrFIEYVRWVRMAKARMILqKYHLSIHEVAQRCGFPDSDYFCRV 267
Cdd:PRK09940 141 NIVNMKLAHPWKLKDICDCLYISESLLKKKLKQEQTT-FSQILLDARMQHAKNLI-RVEGSVNKIAEQCGYASTSYFIYA 218

                         90
                 ....*....|....*..
gi 16130314  268 FRRQFGLTPGEYSARFQ 284
Cdd:PRK09940 219 FRKHFGNSPKRVSKEYR 235
PRK15185 PRK15185
transcriptional regulator HilD; Provisional
 214-279 3.01e-04

transcriptional regulator HilD; Provisional


Pssm-ID: 185107 [Multi-domain]  Cd Length: 309  Bit Score: 41.52  E-value: 3.01e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16130314  214 LSKLFAQHGTmRFIEYVRWVRMAKARMILQKYHLSIHEVAQRCGFPDSDYFCRVFRRQFGLTPGEY 279
Cdd:PRK15185 239 LKRKLAEEGT-SFSDIYLSARMNQAAKLLRIGNHNVNAVALKCGYDSTSYFIQCFKKYFKTTPSTF 303
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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