|
Name |
Accession |
Description |
Interval |
E-value |
| PRK11240 |
PRK11240 |
penicillin-binding protein 1C; Provisional |
3-770 |
0e+00 |
|
penicillin-binding protein 1C; Provisional
Pssm-ID: 183049 [Multi-domain] Cd Length: 772 Bit Score: 1519.23 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 3 RLLTKRGCWITLAAAPFLLFLAAWGADKLWPLPLHEVNPARVVVAQDGTPLWRFADADGIWRYPVTIEDVSPRYLEALIN 82
Cdd:PRK11240 1 RLLTKRGRWLWLAAAPLLLFLALWLADKLWPLPLHEVNPARVVVAEDGTPLWRFADADGIWRYPVTIEDVSPRYLEALIN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 83 YEDRWFWKHPGVNPFSVARAAWQDLTSGRVISGGSTLTMQVARLLDPHPKTFGGKIRQLWRALQLEWHLSKREILTLYLN 162
Cdd:PRK11240 81 YEDRWFWKHPGVNPFSVARAAWQDLTSGRVISGGSTLTMQVARLLDPHPRTFGGKIRQLWRALQLEWHLSKREILTLYLN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 163 RAPFGGTLQGIGAASWAYLGKSPANLSYSEAAMLAVLPQAPSRLRPDRWPERAEAARNKVLERMAVQGVWSREQVKESRE 242
Cdd:PRK11240 161 RAPFGGTLQGIGAASWAYLGKSPANLSYAEAALLAVLPQAPSRLRPDRWPERAEAARNKVLERMAEQGVWSAEQVKESRE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 243 EPIWLAPRQMPQLAPLFSRMMLGKSKSDKITTTLDAGLQRRLEELAQNWKGRLPPRSSLAMIVVDHTDMRVRGWVGSVDL 322
Cdd:PRK11240 241 EPVWLAPRQMPQLAPLFARMMLGKSKSDKIVTTLDAGLQRRLEDLALNWKGRLPPRSSLAMIVVDHTDMAVRGWVGSVDL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 323 NDDSRFGHVDMVNSIRSPGSVLKPFVYGLALDEGLIHPASLLQDVPRRTGDYRPGNFDSGFHGPISMSEALVRSLNLPAV 402
Cdd:PRK11240 321 NDDSRFGHVDMVNAIRSPGSVLKPFVYGLALDDGLIHPASLLQDVPRRTGDYRPGNFDSGFHGPVSMSEALVRSLNLPAV 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 403 QVLEAYGPKRFAAKLRNVGLPLYLPNGAAPNLSLILGGAGAKLEDMAAAYTAFARHGKAGKLRLQPDDPLLERPLMSSGA 482
Cdd:PRK11240 401 QVLEAYGPKRFAAKLRNVGLPLYLPAGAEPNLSLILGGAGARLEDMVAAYSAFARHGKAAKLRLQPDDPLLERPLMSPGA 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 483 AWIIRRIMADEAQPLPDSALPRVAPLAWKTGTSYGYRDAWAIGVNARYVIGIWTGRPDGTPVVGQFGFASAVPLLNQVNN 562
Cdd:PRK11240 481 AWIIRRIMADEAQPLPDAALPRVVPLAWKTGTSYGYRDAWAIGVNARYVIGIWTGRPDGTPVVGQFGFASAVPLLNQVNN 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 563 ILLSRSA----NLPEDPRPNSVTRGVICWPGGQSLPEGDGNCRRRLATWLLDGSQPPTLLLPEQEGINGIRFPIWLDENG 638
Cdd:PRK11240 561 LLLSRSSqrgaNLPEDPRPASVSRGVICWPGGQSLPEGDSNCRRRLATWLLDGSQPPTLLLPEQEGINGIRFPIWLDENG 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 639 KRVAADCPQARQEMINVWPLPLEPWLPASERRAVRLPPASTSCPPYGHDAQLPLQLTGVRDGAIIKRLPGAAEATLPLQS 718
Cdd:PRK11240 641 LRVAADCPQARQEMIAVWPLPLEPWLPASERRAARLPPASTICPPLGHDAALPLQLTGVRDGAVIKRLPGAAEATLPLST 720
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|..
gi 16130444 719 SGGAGERWWFLNGEPLTERGRNVTLHLTDKGDYQLLVMDDVGQIATVKFVMQ 770
Cdd:PRK11240 721 SGGAGRRWWFLNGEPLTERGRNVTLHLTDPGRYQLLVMDESGQIAAVNFVLQ 772
|
|
| PbpC |
COG4953 |
Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope ... |
1-767 |
0e+00 |
|
Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 443980 [Multi-domain] Cd Length: 773 Bit Score: 1065.99 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 1 MPRLLTKRGCWITLAAAPFLLFLAAWGADKLWPLPLH-EVNPARVVVAQDGTPLWRFADADGIWRYPVTIEDVSPRYLEA 79
Cdd:COG4953 1 MKRARLRRRRLLALLLALLLLALALWALDRLFPLPLLfAVPYSTVVLDRDGTLLRAFLAADGQWRLPVPLDEVSPRYLQA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 80 LINYEDRWFWKHPGVNPFSVARAAWQDLTSGRVISGGSTLTMQVARLLDPHPKTFGGKIRQLWRALQLEWHLSKREILTL 159
Cdd:COG4953 81 LLAYEDRRFYYHPGVNPLALLRAAWQNLRSGRIVSGGSTLTMQVARLLEPRPRTLSGKLRQILRALQLERRYSKDEILEL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 160 YLNRAPFGGTLQGIGAASWAYLGKSPANLSYSEAAMLAVLPQAPSRLRPDRWPERAEAARNKVLERMAVQGVWSREQVKE 239
Cdd:COG4953 161 YLNLAPYGGNIEGVEAASLAYFGKPPSRLSLAEAALLAVLPQAPSRRRPDRNPERARAARDRVLARLAEAGVIDAEEAAL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 240 SREEPIWLAPRQMPQLAPLFSRMMLGK-SKSDKITTTLDAGLQRRLEELAQNWKGRL--PPRSSLAMIVVDHTDMRVRGW 316
Cdd:COG4953 241 ALLEPVPARRRPLPQLAPHLARRLLRQlPGGTRIRTTLDAGLQRRLERLVRRYVRRLkqNGIHNAAVLVVDNRTGEVLAY 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 317 VGSVDLNDDSRFGHVDMVNSIRSPGSVLKPFVYGLALDEGLIHPASLLQDVPRRTGDYRPGNFDSGFHGPISMSEALVRS 396
Cdd:COG4953 321 VGSADFFDASRQGQVDMVRALRSPGSTLKPFLYGLALDQGLIHPETLLADVPTSFGGYRPENFDGTFQGPVSAREALARS 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 397 LNLPAVQVLEAYGPKRFAAKLRNVGLPLYLPNGAAPNLSLILGGAGAKLEDMAAAYTAFARHGKAGKLRLQPDDPLL-ER 475
Cdd:COG4953 401 LNIPAVRLLEALGPARFYARLRRAGLRLLLPPAEHYGLSLILGGAEVTLEELVGLYAALARGGEARPLRLLAGEPASpGR 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 476 PLMSSGAAWIIRRIMADEAQPLPD---SALPRVAPLAWKTGTSYGYRDAWAIGVNARYVIGIWTGRPDGTPVVGQFGFAS 552
Cdd:COG4953 481 RLLSPGAAWLVRDILSDVPRPDGAfgwRALDSPPPIAWKTGTSYGFRDAWAVGFTGRYTVGVWVGNPDGTPVPGLTGAEA 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 553 AVPLLNQVNNILLSRSANLPeDPRPNSVTRGVICWPGGQSLPEgdgNCRRRLATWLLDGSQPPTLLLPEQegingirfPI 632
Cdd:COG4953 561 AAPLLFDIFDLLPASRWPLP-FPPPAGLLRVEVCAPSGLLAGP---NCPQRVTEWFIPGTSPPTLCPYHQ--------LV 628
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 633 WLDE-NGKRVAADCP--QARQEMINVWPLPLEPWLPASERRAVRLPPASTSCPPYGHDAQLPLQLTGVRDGAIIKRLPGA 709
Cdd:COG4953 629 WVDAaTGLRVNSDCPpsGARSKVYFVLPPPLERWLARAGRPYRRLPPFRPDCPPLASAAGAAPRIISPPDGARYLLPPGF 708
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16130444 710 AEAT---LPLQSSGGAGERWWFLNGEPL--TERGRNVTLHLTdKGDYQLLVMDDVGQIATVKF 767
Cdd:COG4953 709 PGQQplpLKLAARGGVGPVYWFLDGEPLgtTAPGHELAWQPG-PGFHTLTVVDAAGRSDSVRF 770
|
|
| PBP_1c |
TIGR02073 |
penicillin-binding protein 1C; This subfamily of the penicillin binding proteins includes the ... |
33-770 |
0e+00 |
|
penicillin-binding protein 1C; This subfamily of the penicillin binding proteins includes the member from E. coli designated penicillin-binding protein 1C. Members have both transglycosylase and transpeptidase domains and are involved in forming cross-links in the late stages of peptidoglycan biosynthesis. All members of this subfamily are presumed to have the same basic function. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273954 [Multi-domain] Cd Length: 727 Bit Score: 959.18 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 33 PLPLHEVNP-ARVVVAQDGTPLWRFADADGIWRYPVTIEDVSPRYLEALINYEDRWFWKHPGVNPFSVARAAWQDLTSGR 111
Cdd:TIGR02073 1 PPPLLFHRPsSTVVLDRHGTLLRALLANDGQWRLPVPLEDISPKFLQALLLYEDKRFYWHPGVNPLALLRAAWQNLTNGR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 112 VISGGSTLTMQVARLLDPH-PKTFGGKIRQLWRALQLEWHLSKREILTLYLNRAPFGGTLQGIGAASWAYLGKSPANLSY 190
Cdd:TIGR02073 81 RVSGGSTLTMQLARLLDPElSRTLTGKLRQMWRAIQLEARYSKREILEAYLNLAPYGGNLEGLRAASLIYFGKEPSSLSL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 191 SEAAMLAVLPQAPSRLRPDRWPERAEAARNKVLERMAVQGVWSREQVKESREEPIWLAPRQMPQLAPLFSRMML--GKSK 268
Cdd:TIGR02073 161 AEAALLAALPQAPSARRLDRLPKAAKAARDRLLDRMVEQGPDDSEQVALAALEPLPALPEPLPQLAPHFALKLLraRPEI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 269 SDKITTTLDAGLQRRLEELAQNWKGRLPPR--SSLAMIVVDHTDMRVRGWVGSVDLNDDSRFGHVDMVNSIRSPGSVLKP 346
Cdd:TIGR02073 241 ASVIVSTLDADLQRRLEELARRYLSALRPRgiSNLAILVVDNRSGAVLAYVGSADFFDDSNSGQVDGVRAPRSPGSTLKP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 347 FVYGLALDEGLIHPASLLQDVPRRTGDYRPGNFDSGFHGPISMSEALVRSLNLPAVQVLEAYGPKRFAAKLRNVGLPLYL 426
Cdd:TIGR02073 321 FLYALALDDGLLHPDSLLKDVPLRFGDYAPENFDKTFHGPVPAREALARSLNIPAVRLLERVGPPRFADFLRQAGLNLLK 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 427 PNGAAPNLSLILGGAGAKLEDMAAAYTAFARHGKAGKLR-LQPDDPLLER-PLMSSGAAWIIRRIMADEAQP---LPDSA 501
Cdd:TIGR02073 401 PKSDYYGLSLALGGAEITLQDLANLYAMLANQGLSGPLRfLQTDAKRPEReRLLSPGAAWIVLDILKDRPRPddtLPLSA 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 502 LPRVAPLAWKTGTSYGYRDAWAIGVNARYVIGIWTGRPDGTPVVGQFGFASAVPLLNQVNNILLSRSANLPedPRPNsvt 581
Cdd:TIGR02073 481 LPTRLPLAWKTGTSYGFRDAWAAGVSGRYTIGVWVGNFDGKPNPGFFGAAAAAPLLFDILDALQASEASTL--PRPL--- 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 582 rgvICWPGGQSLPEG-DGNCRRRLATWLLDGSQPPTLLLPEQEGINGIRFPIWLDENGKRVAADCPQARQEMINVWPLPL 660
Cdd:TIGR02073 556 ---KEVPGCLVLGNLpILPCPEQISTWFLPGGSPPTLSEPHKPVVILINEGIAACLPDKPEARQKLALFDVAAYFAQAGL 632
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 661 EPWLPASERRAvrlppastscppyghdaqlPLQLTGVRDGAIIKRLPGAAEATLPLQS--SGGAGERWWFLNGEPLTERG 738
Cdd:TIGR02073 633 PKRKPLLERNA-------------------SLIISPPLDGIYILRDPDGPKAALLLVLiaAGGASGLYWFLDGKLLGEAL 693
|
730 740 750
....*....|....*....|....*....|....
gi 16130444 739 --RNVTLHLTDKGDYQLLVMDDVGQIATVKFVMQ 770
Cdd:TIGR02073 694 pkQSILWWPPAPGFYRLSVVDDDGRIDTLVFFIE 727
|
|
| Transgly |
pfam00912 |
Transglycosylase; The penicillin-binding proteins are bifunctional proteins consisting of ... |
49-227 |
9.09e-73 |
|
Transglycosylase; The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.
Pssm-ID: 459993 [Multi-domain] Cd Length: 177 Bit Score: 234.72 E-value: 9.09e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 49 DGTPLWRFADAdgiWRYPVTIEDVSPRYLEALINYEDRWFWKHPGVNPFSVARAAWQDLTSGRVISGGSTLTMQVAR-LL 127
Cdd:pfam00912 1 DGTLLAELGEE---NREYVPLDDIPPALKNAVLAIEDRRFYEHGGVDPKGIARALLSNLRSGRIVQGGSTITQQLAKnLF 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 128 DPHPKTFGGKIRQLWRALQLEWHLSKREILTLYLNRAPFGGTLQGIGAASWAYLGKSPANLSYSEAAMLAVLPQAPSRLR 207
Cdd:pfam00912 78 LTPERTLTRKLKEAVLALKLERRYSKDEILEAYLNTVYFGRGAYGIEAAARAYFGKDASDLTLAEAALLAGLPQAPSRYN 157
|
170 180
....*....|....*....|
gi 16130444 208 PDRWPERAEAARNKVLERMA 227
Cdd:pfam00912 158 PLRNPERAKRRRNLVLDRMV 177
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK11240 |
PRK11240 |
penicillin-binding protein 1C; Provisional |
3-770 |
0e+00 |
|
penicillin-binding protein 1C; Provisional
Pssm-ID: 183049 [Multi-domain] Cd Length: 772 Bit Score: 1519.23 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 3 RLLTKRGCWITLAAAPFLLFLAAWGADKLWPLPLHEVNPARVVVAQDGTPLWRFADADGIWRYPVTIEDVSPRYLEALIN 82
Cdd:PRK11240 1 RLLTKRGRWLWLAAAPLLLFLALWLADKLWPLPLHEVNPARVVVAEDGTPLWRFADADGIWRYPVTIEDVSPRYLEALIN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 83 YEDRWFWKHPGVNPFSVARAAWQDLTSGRVISGGSTLTMQVARLLDPHPKTFGGKIRQLWRALQLEWHLSKREILTLYLN 162
Cdd:PRK11240 81 YEDRWFWKHPGVNPFSVARAAWQDLTSGRVISGGSTLTMQVARLLDPHPRTFGGKIRQLWRALQLEWHLSKREILTLYLN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 163 RAPFGGTLQGIGAASWAYLGKSPANLSYSEAAMLAVLPQAPSRLRPDRWPERAEAARNKVLERMAVQGVWSREQVKESRE 242
Cdd:PRK11240 161 RAPFGGTLQGIGAASWAYLGKSPANLSYAEAALLAVLPQAPSRLRPDRWPERAEAARNKVLERMAEQGVWSAEQVKESRE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 243 EPIWLAPRQMPQLAPLFSRMMLGKSKSDKITTTLDAGLQRRLEELAQNWKGRLPPRSSLAMIVVDHTDMRVRGWVGSVDL 322
Cdd:PRK11240 241 EPVWLAPRQMPQLAPLFARMMLGKSKSDKIVTTLDAGLQRRLEDLALNWKGRLPPRSSLAMIVVDHTDMAVRGWVGSVDL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 323 NDDSRFGHVDMVNSIRSPGSVLKPFVYGLALDEGLIHPASLLQDVPRRTGDYRPGNFDSGFHGPISMSEALVRSLNLPAV 402
Cdd:PRK11240 321 NDDSRFGHVDMVNAIRSPGSVLKPFVYGLALDDGLIHPASLLQDVPRRTGDYRPGNFDSGFHGPVSMSEALVRSLNLPAV 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 403 QVLEAYGPKRFAAKLRNVGLPLYLPNGAAPNLSLILGGAGAKLEDMAAAYTAFARHGKAGKLRLQPDDPLLERPLMSSGA 482
Cdd:PRK11240 401 QVLEAYGPKRFAAKLRNVGLPLYLPAGAEPNLSLILGGAGARLEDMVAAYSAFARHGKAAKLRLQPDDPLLERPLMSPGA 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 483 AWIIRRIMADEAQPLPDSALPRVAPLAWKTGTSYGYRDAWAIGVNARYVIGIWTGRPDGTPVVGQFGFASAVPLLNQVNN 562
Cdd:PRK11240 481 AWIIRRIMADEAQPLPDAALPRVVPLAWKTGTSYGYRDAWAIGVNARYVIGIWTGRPDGTPVVGQFGFASAVPLLNQVNN 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 563 ILLSRSA----NLPEDPRPNSVTRGVICWPGGQSLPEGDGNCRRRLATWLLDGSQPPTLLLPEQEGINGIRFPIWLDENG 638
Cdd:PRK11240 561 LLLSRSSqrgaNLPEDPRPASVSRGVICWPGGQSLPEGDSNCRRRLATWLLDGSQPPTLLLPEQEGINGIRFPIWLDENG 640
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 639 KRVAADCPQARQEMINVWPLPLEPWLPASERRAVRLPPASTSCPPYGHDAQLPLQLTGVRDGAIIKRLPGAAEATLPLQS 718
Cdd:PRK11240 641 LRVAADCPQARQEMIAVWPLPLEPWLPASERRAARLPPASTICPPLGHDAALPLQLTGVRDGAVIKRLPGAAEATLPLST 720
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|..
gi 16130444 719 SGGAGERWWFLNGEPLTERGRNVTLHLTDKGDYQLLVMDDVGQIATVKFVMQ 770
Cdd:PRK11240 721 SGGAGRRWWFLNGEPLTERGRNVTLHLTDPGRYQLLVMDESGQIAAVNFVLQ 772
|
|
| PbpC |
COG4953 |
Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope ... |
1-767 |
0e+00 |
|
Membrane carboxypeptidase/penicillin-binding protein PbpC [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 443980 [Multi-domain] Cd Length: 773 Bit Score: 1065.99 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 1 MPRLLTKRGCWITLAAAPFLLFLAAWGADKLWPLPLH-EVNPARVVVAQDGTPLWRFADADGIWRYPVTIEDVSPRYLEA 79
Cdd:COG4953 1 MKRARLRRRRLLALLLALLLLALALWALDRLFPLPLLfAVPYSTVVLDRDGTLLRAFLAADGQWRLPVPLDEVSPRYLQA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 80 LINYEDRWFWKHPGVNPFSVARAAWQDLTSGRVISGGSTLTMQVARLLDPHPKTFGGKIRQLWRALQLEWHLSKREILTL 159
Cdd:COG4953 81 LLAYEDRRFYYHPGVNPLALLRAAWQNLRSGRIVSGGSTLTMQVARLLEPRPRTLSGKLRQILRALQLERRYSKDEILEL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 160 YLNRAPFGGTLQGIGAASWAYLGKSPANLSYSEAAMLAVLPQAPSRLRPDRWPERAEAARNKVLERMAVQGVWSREQVKE 239
Cdd:COG4953 161 YLNLAPYGGNIEGVEAASLAYFGKPPSRLSLAEAALLAVLPQAPSRRRPDRNPERARAARDRVLARLAEAGVIDAEEAAL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 240 SREEPIWLAPRQMPQLAPLFSRMMLGK-SKSDKITTTLDAGLQRRLEELAQNWKGRL--PPRSSLAMIVVDHTDMRVRGW 316
Cdd:COG4953 241 ALLEPVPARRRPLPQLAPHLARRLLRQlPGGTRIRTTLDAGLQRRLERLVRRYVRRLkqNGIHNAAVLVVDNRTGEVLAY 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 317 VGSVDLNDDSRFGHVDMVNSIRSPGSVLKPFVYGLALDEGLIHPASLLQDVPRRTGDYRPGNFDSGFHGPISMSEALVRS 396
Cdd:COG4953 321 VGSADFFDASRQGQVDMVRALRSPGSTLKPFLYGLALDQGLIHPETLLADVPTSFGGYRPENFDGTFQGPVSAREALARS 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 397 LNLPAVQVLEAYGPKRFAAKLRNVGLPLYLPNGAAPNLSLILGGAGAKLEDMAAAYTAFARHGKAGKLRLQPDDPLL-ER 475
Cdd:COG4953 401 LNIPAVRLLEALGPARFYARLRRAGLRLLLPPAEHYGLSLILGGAEVTLEELVGLYAALARGGEARPLRLLAGEPASpGR 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 476 PLMSSGAAWIIRRIMADEAQPLPD---SALPRVAPLAWKTGTSYGYRDAWAIGVNARYVIGIWTGRPDGTPVVGQFGFAS 552
Cdd:COG4953 481 RLLSPGAAWLVRDILSDVPRPDGAfgwRALDSPPPIAWKTGTSYGFRDAWAVGFTGRYTVGVWVGNPDGTPVPGLTGAEA 560
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 553 AVPLLNQVNNILLSRSANLPeDPRPNSVTRGVICWPGGQSLPEgdgNCRRRLATWLLDGSQPPTLLLPEQegingirfPI 632
Cdd:COG4953 561 AAPLLFDIFDLLPASRWPLP-FPPPAGLLRVEVCAPSGLLAGP---NCPQRVTEWFIPGTSPPTLCPYHQ--------LV 628
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 633 WLDE-NGKRVAADCP--QARQEMINVWPLPLEPWLPASERRAVRLPPASTSCPPYGHDAQLPLQLTGVRDGAIIKRLPGA 709
Cdd:COG4953 629 WVDAaTGLRVNSDCPpsGARSKVYFVLPPPLERWLARAGRPYRRLPPFRPDCPPLASAAGAAPRIISPPDGARYLLPPGF 708
|
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16130444 710 AEAT---LPLQSSGGAGERWWFLNGEPL--TERGRNVTLHLTdKGDYQLLVMDDVGQIATVKF 767
Cdd:COG4953 709 PGQQplpLKLAARGGVGPVYWFLDGEPLgtTAPGHELAWQPG-PGFHTLTVVDAAGRSDSVRF 770
|
|
| PBP_1c |
TIGR02073 |
penicillin-binding protein 1C; This subfamily of the penicillin binding proteins includes the ... |
33-770 |
0e+00 |
|
penicillin-binding protein 1C; This subfamily of the penicillin binding proteins includes the member from E. coli designated penicillin-binding protein 1C. Members have both transglycosylase and transpeptidase domains and are involved in forming cross-links in the late stages of peptidoglycan biosynthesis. All members of this subfamily are presumed to have the same basic function. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273954 [Multi-domain] Cd Length: 727 Bit Score: 959.18 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 33 PLPLHEVNP-ARVVVAQDGTPLWRFADADGIWRYPVTIEDVSPRYLEALINYEDRWFWKHPGVNPFSVARAAWQDLTSGR 111
Cdd:TIGR02073 1 PPPLLFHRPsSTVVLDRHGTLLRALLANDGQWRLPVPLEDISPKFLQALLLYEDKRFYWHPGVNPLALLRAAWQNLTNGR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 112 VISGGSTLTMQVARLLDPH-PKTFGGKIRQLWRALQLEWHLSKREILTLYLNRAPFGGTLQGIGAASWAYLGKSPANLSY 190
Cdd:TIGR02073 81 RVSGGSTLTMQLARLLDPElSRTLTGKLRQMWRAIQLEARYSKREILEAYLNLAPYGGNLEGLRAASLIYFGKEPSSLSL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 191 SEAAMLAVLPQAPSRLRPDRWPERAEAARNKVLERMAVQGVWSREQVKESREEPIWLAPRQMPQLAPLFSRMML--GKSK 268
Cdd:TIGR02073 161 AEAALLAALPQAPSARRLDRLPKAAKAARDRLLDRMVEQGPDDSEQVALAALEPLPALPEPLPQLAPHFALKLLraRPEI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 269 SDKITTTLDAGLQRRLEELAQNWKGRLPPR--SSLAMIVVDHTDMRVRGWVGSVDLNDDSRFGHVDMVNSIRSPGSVLKP 346
Cdd:TIGR02073 241 ASVIVSTLDADLQRRLEELARRYLSALRPRgiSNLAILVVDNRSGAVLAYVGSADFFDDSNSGQVDGVRAPRSPGSTLKP 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 347 FVYGLALDEGLIHPASLLQDVPRRTGDYRPGNFDSGFHGPISMSEALVRSLNLPAVQVLEAYGPKRFAAKLRNVGLPLYL 426
Cdd:TIGR02073 321 FLYALALDDGLLHPDSLLKDVPLRFGDYAPENFDKTFHGPVPAREALARSLNIPAVRLLERVGPPRFADFLRQAGLNLLK 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 427 PNGAAPNLSLILGGAGAKLEDMAAAYTAFARHGKAGKLR-LQPDDPLLER-PLMSSGAAWIIRRIMADEAQP---LPDSA 501
Cdd:TIGR02073 401 PKSDYYGLSLALGGAEITLQDLANLYAMLANQGLSGPLRfLQTDAKRPEReRLLSPGAAWIVLDILKDRPRPddtLPLSA 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 502 LPRVAPLAWKTGTSYGYRDAWAIGVNARYVIGIWTGRPDGTPVVGQFGFASAVPLLNQVNNILLSRSANLPedPRPNsvt 581
Cdd:TIGR02073 481 LPTRLPLAWKTGTSYGFRDAWAAGVSGRYTIGVWVGNFDGKPNPGFFGAAAAAPLLFDILDALQASEASTL--PRPL--- 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 582 rgvICWPGGQSLPEG-DGNCRRRLATWLLDGSQPPTLLLPEQEGINGIRFPIWLDENGKRVAADCPQARQEMINVWPLPL 660
Cdd:TIGR02073 556 ---KEVPGCLVLGNLpILPCPEQISTWFLPGGSPPTLSEPHKPVVILINEGIAACLPDKPEARQKLALFDVAAYFAQAGL 632
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 661 EPWLPASERRAvrlppastscppyghdaqlPLQLTGVRDGAIIKRLPGAAEATLPLQS--SGGAGERWWFLNGEPLTERG 738
Cdd:TIGR02073 633 PKRKPLLERNA-------------------SLIISPPLDGIYILRDPDGPKAALLLVLiaAGGASGLYWFLDGKLLGEAL 693
|
730 740 750
....*....|....*....|....*....|....
gi 16130444 739 --RNVTLHLTDKGDYQLLVMDDVGQIATVKFVMQ 770
Cdd:TIGR02073 694 pkQSILWWPPAPGFYRLSVVDDDGRIDTLVFFIE 727
|
|
| MrcB |
COG0744 |
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall ... |
9-582 |
1.33e-144 |
|
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440507 [Multi-domain] Cd Length: 630 Bit Score: 438.20 E-value: 1.33e-144
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 9 GCWITLAAAPFLLFLAAWGADKLWPLP----LHEVNPAR--VVVAQDGTPLWRFADADgiwRYPVTIEDVSPRYLEALIN 82
Cdd:COG0744 16 GLLLLLLAVLVLAALAGLVALYVADLPdpeeLEDLALPQtsTIYDRDGTLIATLGDEN---REWVPLDQIPPHLKDAVVA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 83 YEDRWFWKHPGVNPFSVARAAWQDLTSGRVISGGSTLTMQVARLLDPHP-KTFGGKIRQLWRALQLEWHLSKREILTLYL 161
Cdd:COG0744 93 IEDRRFYEHGGVDPKGIARALVANLTAGGVVQGGSTITQQLVKNLFLSNeRTLSRKLKEALLALKLERKYSKDEILELYL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 162 NRAPFGGTLQGIGAASWAYLGKSPANLSYSEAAMLAVLPQAPSRLRPDRWPERAEAARNKVLERMAVQGVWSREQVKESR 241
Cdd:COG0744 173 NTVYFGRGAYGIEAAAQYYFGKSASDLTLAEAALLAGLVKAPSYYDPYRNPEAAKERRNLVLDRMVEQGYITQAEADAAK 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 242 EEPIWLAPRQ---------------MPQLAPLFSRMMLgKSKSDKITTTLDAGLQRRLEELAQNW-KGRLPPRSSLAMIV 305
Cdd:COG0744 253 AEPLTLVPPPngaaagkypyfvdyvRRELEELLGEDDL-YRGGLKIYTTLDPKLQKAAEKAVKNVlPEGKPGGLQAALVV 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 306 VDHTDMRVRGWVGSVDLNdDSRFGHVdmVNSIRSPGSVLKPFVYGLALDEGlIHPASLLQDVPR--RTGDYRPGNFDSGF 383
Cdd:COG0744 332 VDPKTGEVLAMVGGRDYG-KSQFNRA--TQAKRQPGSTFKPFVYAAALEQG-YTPATTVDDEPVtfPGGGWSPKNYDGRY 407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 384 HGPISMSEALVRSLNLPAVQVLEAYGPKRFAAKLRNVGLPLYLPngaaPNLSLILGGAGAKLEDMAAAYTAFARHGKA-- 461
Cdd:COG0744 408 RGPVTLREALANSLNTPAVRLAQEVGLDKVVDTARRLGITSPLD----PNPSLALGTSEVSPLEMASAYATFANGGVYve 483
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 462 -----------GKLRLQPDDPllERPLMSSGAAWIIRRIMADEAQP-LPDSALPRVAPLAWKTGTSYGYRDAWAIGVNAR 529
Cdd:COG0744 484 phaitkvtdadGKVLYEAKPK--CEQVISPEVAYLMTDMLQDVVTSgTGRAARLPGRPVAGKTGTTNDNRDAWFVGYTPQ 561
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*
gi 16130444 530 YVIGIWTGRPDGTPVVGQFGFASAVPLlnqVNNILLSRSANLPED--PRPNSVTR 582
Cdd:COG0744 562 LVTAVWVGNDDNSPMGYVTGGSLPAPI---WRDFMEAALEGLPVEdfPKPSGVVR 613
|
|
| PBP_1a_fam |
TIGR02074 |
penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan ... |
64-556 |
1.33e-116 |
|
penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273955 [Multi-domain] Cd Length: 531 Bit Score: 362.35 E-value: 1.33e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 64 RYPVTIEDVSPRYLEALINYEDRWFWKHPGVNPFSVARAAWQDLTSGRVISGGSTLTMQVARL--LDPHpKTFGGKIRQL 141
Cdd:TIGR02074 2 REYVPIDDIPENLINAFLAIEDRRFYDHFGIDLKGIGRAAVANITSGRVLEGGSTITQQLAKNlyLTNE-RTITRKIQEA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 142 WRALQLEWHLSKREILTLYLNRAPFGGTLQGIGAASWAYLGKSPANLSYSEAAMLAVLPQAPSRLRPDRWPERAEAARNK 221
Cdd:TIGR02074 81 LLALKLEQKLSKDEILELYLNRIYFGNGAYGIEAAAQFYFGKSVNDLTLAEAAMLAGLPKAPSAYNPFKNPERAKDRRNL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 222 VLERMAVQGVWSREQVKESREEPIWLAPRQMPQL---APLFSRM-------MLGKSKSD---KITTTLDAGLQRRLEELA 288
Cdd:TIGR02074 161 VLSNMVENGYITAEEAEEAINEPIQLYLQTKKSEqykAPYFVDYviqeleeEYGEELYTgglKIYTTLDLDAQKAAEKVL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 289 QNWKGRLPPRSSL----AMIVVDHTDMRVRGWVGSVDLNDdSRFGHVdmVNSIRSPGSVLKPFVYGLALDEGLiHPASLL 364
Cdd:TIGR02074 241 NTGLRVAGRRDGDdlqaALVAIDPDTGAVRALVGGRDYGK-SQFNRA--TQAKRQPGSTFKPFVYAAALEKGL-TPATIV 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 365 QDVPR---RTGDYRPGNFDSGFHGPISMSEALVRSLNLPAVQVLEAYGPKRFAAKLRNVGLPLYLPngaaPNLSLILGGA 441
Cdd:TIGR02074 317 NDEPItynGNGPWSPKNYGGGYRGNVTLRQALAQSRNIPAVRLLQEVGLDKVVALAKRFGITSPLD----PVLSLALGTV 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 442 GAKLEDMAAAYTAFARHGKAGK---------------LRLQPDdpllERPLMSSGAAWIIRRIMADeaqpLPDSALPRVA 506
Cdd:TIGR02074 393 EVSPLEMASAYAVFANGGKYVEphgirkivdrdgkviYENKPK----TTQVISPATAYIMTDMLKG----VVESGTGRSA 464
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 16130444 507 -----PLAWKTGTSYGYRDAWAIGVNARYVIGIWTGRPD-GTPVVGQFGFASAVPL 556
Cdd:TIGR02074 465 rlpgrPVAGKTGTTQNWRDAWFVGYTPYYVTAVWVGYDDkKTLGKSGTGGGLAAPI 520
|
|
| MrcA |
COG5009 |
Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis]; |
3-543 |
6.47e-107 |
|
Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 444033 [Multi-domain] Cd Length: 785 Bit Score: 344.84 E-value: 6.47e-107
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 3 RLLtKRGCWITLAAApFLLFLAAWGA-DKLWP-LP----LHEVNPARV--VVAQDGTPLWRFADAdgiWRYPVTIEDVSP 74
Cdd:COG5009 2 RLL-KILLILLLLLL-LLGALAVAGLyLYLSPdLPdvetLKDYQPPTPsrVYSADGKLIAEFGEE---RRIPVPIEEIPP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 75 RYLEALINYEDRWFWKHPGVNPFSVARAAWQDLTSGRVISGGSTLTMQVAR--LLDPHpKTFGGKIRQLWRALQLEWHLS 152
Cdd:COG5009 77 LLINAFLAAEDKRFYEHPGVDPIGIARAAVVNLRTGRRVQGGSTITQQVAKnfLLSPE-RTLTRKIKEAILALRIEQELS 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 153 KREILTLYLNRAPFGGTLQGIGAASWAYLGKSPANLSYSEAAMLAVLPQAPSRLRPDRWPERAEAARNKVLERMAVQGVW 232
Cdd:COG5009 156 KDEILELYLNKIYLGHRAYGVAAAAQTYFGKSLDELTLAEAAMLAGLPKAPSRYNPIRNPERALERRNYVLGRMLELGYI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 233 SREQVKESREEPIWLAPRQMPQL--APLFS----RMMLGKSKSD-------KITTTLDAGLQR----------------- 282
Cdd:COG5009 236 TQAEYEAAKAEPLTARYHGASAEvdAPYFAemvrRELVERYGEDalytgglKVYTTLDPRLQEaaekalrdgllaydrrh 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 283 -------RLEELAQNW----------------------------------KGRLP------------------------- 296
Cdd:COG5009 316 gyrgpeaHLDLAEEDWdealaevpdvgdlrpavvlevddksarvglrdgeTGTLPleglkwarpyindnrrgpapksasd 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 297 -----------------------PRSSLAMIVVDHTDMRVRGWVGSVDLNdDSRFGHVdmVNSIRSPGSVLKPFVYGLAL 353
Cdd:COG5009 396 vlkpgdvirvrpvadggwrlrqiPEVQGALVALDPHTGAVLALVGGFDFE-QSKFNRA--TQAKRQPGSSFKPFVYAAAL 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 354 DEGlIHPASLLQDVP------RRTGDYRPGNFDSGFHGPISMSEALVRSLNLPAVQVLEAYGPKRFAAKLRNVGLPLYLP 427
Cdd:COG5009 473 DNG-YTPATIINDAPivfddgGGGGVWRPKNYSGKFYGPTTLREALEKSRNLVTVRLLQDVGIDYVIDYAERFGIYSKLP 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 428 ngaaPNLSLILGGAGAKLEDMAAAYTAFARHGKA-------------GKL----------------RLQPDDPLLERP-- 476
Cdd:COG5009 552 ----PNLSLALGSGEVTPLEMARAYAVFANGGYRvepylidriedrnGKViyradparacedcdaaEWDGAEPRLPDPae 627
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16130444 477 -LMSSGAAWIIRRIMAD--------EAQplpdsALPRvaPLAWKTGTSYGYRDAWAIGVNARYVIGIWTGRPDGTP 543
Cdd:COG5009 628 qVIDPRTAYQMTSMLRGvvqrgtgrRAR-----ALGR--DIAGKTGTTNDSKDAWFVGFTPDLVAGVWVGFDDPRS 696
|
|
| Transgly |
pfam00912 |
Transglycosylase; The penicillin-binding proteins are bifunctional proteins consisting of ... |
49-227 |
9.09e-73 |
|
Transglycosylase; The penicillin-binding proteins are bifunctional proteins consisting of transglycosylase and transpeptidase in the N- and C-terminus respectively. The transglycosylase domain catalyzes the polymerization of murein glycan chains.
Pssm-ID: 459993 [Multi-domain] Cd Length: 177 Bit Score: 234.72 E-value: 9.09e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 49 DGTPLWRFADAdgiWRYPVTIEDVSPRYLEALINYEDRWFWKHPGVNPFSVARAAWQDLTSGRVISGGSTLTMQVAR-LL 127
Cdd:pfam00912 1 DGTLLAELGEE---NREYVPLDDIPPALKNAVLAIEDRRFYEHGGVDPKGIARALLSNLRSGRIVQGGSTITQQLAKnLF 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 128 DPHPKTFGGKIRQLWRALQLEWHLSKREILTLYLNRAPFGGTLQGIGAASWAYLGKSPANLSYSEAAMLAVLPQAPSRLR 207
Cdd:pfam00912 78 LTPERTLTRKLKEAVLALKLERRYSKDEILEAYLNTVYFGRGAYGIEAAARAYFGKDASDLTLAEAALLAGLPQAPSRYN 157
|
170 180
....*....|....*....|
gi 16130444 208 PDRWPERAEAARNKVLERMA 227
Cdd:pfam00912 158 PLRNPERAKRRRNLVLDRMV 177
|
|
| mrcA |
PRK11636 |
penicillin-binding protein 1a; Provisional |
64-459 |
5.64e-43 |
|
penicillin-binding protein 1a; Provisional
Pssm-ID: 183248 [Multi-domain] Cd Length: 850 Bit Score: 167.62 E-value: 5.64e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 64 RYPVTIEDVSPRYLEALINYEDRWFWKHPGVNPFSVARAAWQDLTSGRVISGGSTLTMQVAR--LLDPHpKTFGGKIRQL 141
Cdd:PRK11636 66 RIPLTLDQIPPEMVKAFIATEDSRFYEHHGVDPVGIFRAASVALFSGHASQGASTITQQLARnfFLSPE-RTLMRKIKEA 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 142 WRALQLEWHLSKREILTLYLNRAPFGGTLQGIGAASWAYLGKSPANLSYSEAAMLAVLPQAPSRLRPDRWPERAEAARNK 221
Cdd:PRK11636 145 FLAIRIEQLLTKDEILELYLNKIYLGYRAYGVGAAAQVYFGKTVDQLTLSEMAVIAGLPKAPSTFNPLYSMDRAVARRNV 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 222 VLERMAVQGVWSREQVKESREEPI---WLAP-------------RQ---------------------------------- 251
Cdd:PRK11636 225 VLSRMLDEGYITQAQYDQARSEPIvanYHAPeiafsapylsemvRQemynrygenayedgyrvyttitrkvqqaaqqavr 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 252 --------------------------------------MPQLAPLFSRMMLGKS-------------------------- 267
Cdd:PRK11636 305 nnvldydmrhgyrgpanvlwkvgesawdnkkitdtlkaLPTYGPLLPAVVTSANpqeatamladgssvalpmegvrwarp 384
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 268 -KSD--------KITTTLDAGLQRRLEELAQNWKGRLPPRSSLAMIVVDHTDMRVRGWVGSVDLNdDSRFGHVdmVNSIR 338
Cdd:PRK11636 385 yRSDtqqgptprKVTDVVQTGQQIWVRQVDDAWWLAQVPDVNSALVSINPQNGAVMALVGGFDFN-QSKFNRA--TQALR 461
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 339 SPGSVLKPFVYGLALDEGLIHpASLLQDVPRRT------GDYRPGNFDSGFHGPISMSEALVRSLNLPAVQVLEAYGPKR 412
Cdd:PRK11636 462 QVGSNIKPFLYTAAMDKGLTL-ASMLNDVPISRwdagagSDWRPKNSPPQYAGPIRLRQGLGQSKNVVMVRAMRAMGVDY 540
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 16130444 413 FAAKLRNVGLPlylpngaAPNL----SLILGGAGAKLEDMAAAYTAFARHG 459
Cdd:PRK11636 541 AAEYLQRFGFP-------AQNIvhteSLALGSASFTPMQVARGYAVMANGG 584
|
|
| mrcB |
PRK09506 |
bifunctional glycosyl transferase/transpeptidase; Reviewed |
80-543 |
1.70e-38 |
|
bifunctional glycosyl transferase/transpeptidase; Reviewed
Pssm-ID: 236544 [Multi-domain] Cd Length: 830 Bit Score: 153.77 E-value: 1.70e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 80 LINYEDRWFWKHPGVNPFSVARAAWQDLTSGRVISGGSTLTMQVARLLdphpktFGGKIRQLWR-------ALQLEWHLS 152
Cdd:PRK09506 227 LLATEDRHFYEHDGISLYSIGRAVLANLTAGRTVQGGSTLTQQLVKNL------FLSNERSLWRkaneaymALIMDARYS 300
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 153 KREILTLYLNRAPFG----GTLQGIGAASWAYLGKSPANLSYSEAAMLAVLPQAPSRLRPDRWPERAEAARNKVLERMAV 228
Cdd:PRK09506 301 KDRILELYLNEVYLGqsgdDQIRGFPLASLYYFGRPVEELSLDQQALLVGMVKGASLYNPWRNPKLALERRNLVLRLLQQ 380
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 229 QGVWSREQVKESREEPIWLAPRQ---MPQlaPLFSRMM-------LGKSKSD----KITTTLDAGLQRRLEELAQNWKGR 294
Cdd:PRK09506 381 QQIIDQELYDMLSARPLGVQPKGgviSPQ--PAFMQMVrqelqakLGDKVKDlsgvKIFTTLDPVSQDAAEKAVEEGIPA 458
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 295 LPPRSSL-----AMIVVDHTDMRVRGWVGSVdlndDSRF-GHVDMVNSIRSPGSVLKPFVYGLALDE-GLIHPASLLQDV 367
Cdd:PRK09506 459 LKKQRKLsdletAMVVVDRFSGEVRAMVGGS----EPQFaGYNRAMQARRSIGSLAKPATYLTALSQpDKYRLNTWIADA 534
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 368 P-----RRTGDYRPGNFDSGFHGPISMSEALVRSLNLPAVQVLEAYGPKRFAAKLRNVGLPlylPNGAAPNLSLILGGAG 442
Cdd:PRK09506 535 PislrqPNGQVWSPQNDDRRFSGRVMLVDALTRSMNVPTVNLGMALGLPAVTDTWIKLGVP---KDQLNPVPAMLLGALN 611
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 443 AKLEDMAAAYTAFARHGKAGKLR-----LQPDDPLL-------ERpLMSSGAAWIIRRIMADEAQPLPDSALPRVAP--- 507
Cdd:PRK09506 612 LTPIEVAQAFQTIASGGNRAPLSalrsvIAEDGKVLyqsfpqaER-AVPAQAAYLTLYTMQQVVQRGTGRQLGAKYPnlh 690
|
490 500 510
....*....|....*....|....*....|....*.
gi 16130444 508 LAWKTGTSYGYRDAWAIGVNARYVIGIWTGRPDGTP 543
Cdd:PRK09506 691 LAGKTGTTNDLVDSWFAGIDGKEVTITWVGRDNNQP 726
|
|
| PRK14850 |
PRK14850 |
penicillin-binding protein 1b; Provisional |
77-538 |
3.09e-36 |
|
penicillin-binding protein 1b; Provisional
Pssm-ID: 237835 [Multi-domain] Cd Length: 764 Bit Score: 146.53 E-value: 3.09e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 77 LEALINYEDRWFWKHPGVNPFSVARAAWQDLTSGRVISGGSTLTMQVARLLdphpktFGGKIRQLWR-------ALQLEW 149
Cdd:PRK14850 170 IKTLLAIEDKYFYEHDGIHLSSIGRAFLVNLMSGHTIQGGSTLTQQLVKNL------FLTNTRSLWRkineiymALILDR 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 150 HLSKREILTLYLNRAPFGG----TLQGIGAASWAYLGKSPANLSYSEAAMLAVLPQAPSRLRPDRWPERAEAARN----- 220
Cdd:PRK14850 244 FYSKDRILELYLNEVYLGQdgneQIRGFPLASIYYFGRPINELNLDQYALLVGMVKGASLYNPWTNPNLTLKRRNlvlfl 323
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 221 ----KVLERMAVQGVWSREQVKESREEPIWLAPRQMPQLAPLFSRmMLGKSKSD----KITTTLDAGLQRRLEELAQNWK 292
Cdd:PRK14850 324 lykqKVITRKLYKDLCSRPLNVQSKGNIISSHPAFIQLVCEEFHK-KIHYPFKNfsgtKIFTTLDYISQNAAEQAVKIGI 402
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 293 GRLPPRSSL-----AMIVVDHTDMRVRGWVGSVDLNDDsrfGHVDMVNSIRSPGSVLKPFVYGLALDE-GLIHPASLLQD 366
Cdd:PRK14850 403 PILKRKKRLkdlevAMVIIDRFSGEVRALIGSSKPEFN---GYNRALKARRSIGSLSKPITYLTALSQpEKYHLNTWISD 479
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 367 VP----RRTGDY-RPGNFDSGFHGPISMSEALVRSLNLPAVQVLEAYGPKRFAAKLRNVGLPlylPNGAAPNLSLILGGA 441
Cdd:PRK14850 480 TPisikLDNGQYwTPKNNNFSFSGKVMLIDALIHSINIPTVHLSINLGLKKLVDSWILLGIS---SNYITPLPSISLGAI 556
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 442 GAKLEDMAAAYTAFARHGKAGKLR-----LQPDDPLLERPLMSSgaawiiRRIMADEAQPLPDSALPRVAP--------- 507
Cdd:PRK14850 557 NLTPMEVAQVFQIIGSGGYKSSLSsirsiISDDNKVLYQNFPQS------KHVESSQASYLTLYAMQQVVKsgtakslgt 630
|
490 500 510
....*....|....*....|....*....|....*..
gi 16130444 508 ------LAWKTGTSYGYRDAWAIGVNARYVIGIWTGR 538
Cdd:PRK14850 631 ifkefsLAGKTGTTNNLVDSWFVGIDGKQVVITWIGR 667
|
|
| Transpeptidase |
pfam00905 |
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ... |
304-560 |
6.84e-16 |
|
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.
Pssm-ID: 425939 [Multi-domain] Cd Length: 296 Bit Score: 79.00 E-value: 6.84e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 304 IVVDHTDMRVRGWVG--SVDLNDDSRFGHVDMVNSIRSPGSVLKPFVYGLALDEGLIHPASLLQDVPRRTGDYRP-GNFD 380
Cdd:pfam00905 4 VVLDPKTGEVLAMVGkpSYDPNGFIGPLRNRAVTSRYEPGSTFKPFTALAALDNGVLKPDETIFDWPGKQQGGKSiGDWN 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 381 SGFHGPISMSEALVRSLNLPAVQVLEAYGPKRFAAKLRNVGL----PLYLP---NGAAPNL----SLILGGAGAKL--ED 447
Cdd:pfam00905 84 QDQVGIGTLRQALEYSSNWYMQKLAQKLGADKLRSYLKKFGYgnktGIGLPgenAGYLTPYwlegATASFGIGLTItpLQ 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 448 MAAAYTAFARHGKAGKLRL-------QPDDPLLERPlMSSGAAWIIRRIMADEAQPLPDSALPRVA--PLAWKTGTS--- 515
Cdd:pfam00905 164 QAQAYAAIANGGKLVPPHLvksiedkVDPKVLNKLP-ISKSTAEKVKDMLRLVVNDGTGTGTAAVPgyKVAGKTGTAqva 242
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 16130444 516 ----YGYRD----AWAIGV----NARYVIGIWTgrPDGTpvvGQFGFASAVPLLNQV 560
Cdd:pfam00905 243 gpkgGGYYDgaqiGWFVGYapadNPKYAFAVLI--DDPK---RYYGGKVAAPIFKDI 294
|
|
| BiPBP_C |
pfam06832 |
Penicillin-Binding Protein C-terminus Family; This conserved region of approximately 90 ... |
691-767 |
3.21e-15 |
|
Penicillin-Binding Protein C-terminus Family; This conserved region of approximately 90 residues is found in a sub-group of bacterial Penicillin-Binding Proteins (PBPs). A variable length loop region separates this region from the transpeptidase unit (pfam00905). It is predicted by PROF to be an all beta fold.
Pssm-ID: 429142 [Multi-domain] Cd Length: 89 Bit Score: 71.60 E-value: 3.21e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 691 PLQLTGVRDGAIIKRLPGAAEA-TLPLQSSGGAGERWWFLNGEPL--TERGRNVTLHLtDKGDYQLLVMDDVGQIATVKF 767
Cdd:pfam06832 11 PPRILFPPDGAVIALDPDIPAAqRLVLKAAGGRGPLYWLLDGKPLgeTGSGRELFWLP-GPGFHRLTVVDAAGRTADVRF 89
|
|
| FtsI |
COG0768 |
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ... |
272-492 |
5.59e-15 |
|
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440531 [Multi-domain] Cd Length: 568 Bit Score: 78.71 E-value: 5.59e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 272 ITTTLDAGLQRRLEELAQNWKGRLPPRSSlAMIVVDHTDMRVRGWVG--SVDLNDDSRFGHVDMVN-SIRS---PGSVLK 345
Cdd:COG0768 221 LVLTIDSDLQKIAEEALKKAVEEYKAKSG-AVVVMDPKTGEILAMASypSFDPNLFVGGPDEPLRNrAVQGtyePGSTFK 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 346 PFVYGLALDEGLIHPASLLQDVPR-RTGDYRPGNFDSGFHGPISMSEALVRSLNLPAVQVLEAYGPKRFAAKLRNVGL-- 422
Cdd:COG0768 300 PFTAAAALEEGVITPDTTFDCPGYyRVGGRTIRDWDRGGHGTLTLTEALAKSSNVGFYKLALRLGIDKLYDYLKKFGLgq 379
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 423 --PLYLPNGAAPNL----------SLILG-GAGAK---LEdMAAAYTAFARHGKAGKLRL-----------QPDDPLLER 475
Cdd:COG0768 380 ktGIDLPGEASGLLpspkrwypgeTATMSiGQGLSvtpLQ-LAQAYAAIANGGVLVKPHLvkeivdpdgevVKEEPEVLR 458
|
250
....*....|....*..
gi 16130444 476 PLMSSGAAWIIRRIMAD 492
Cdd:COG0768 459 RVISPETAETVREGMEG 475
|
|
| PRK13481 |
PRK13481 |
glycosyltransferase; Provisional |
74-240 |
9.27e-15 |
|
glycosyltransferase; Provisional
Pssm-ID: 184078 [Multi-domain] Cd Length: 232 Bit Score: 74.45 E-value: 9.27e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 74 PRYLE-ALINYEDRWFWKHPGVNPFSVARAAWQDLTSGRViSGGSTLTMQVAR--LLDpHPKTFGGKIRQLWRALQLEWH 150
Cdd:PRK13481 54 PEYVKgAFISMEDERFYKHHGFDLKGTTRALFSTISDRDV-QGGSTITQQVVKnyFYD-NERSFTRKVKELFVAHRVEKQ 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 151 LSKREILTLYLNRAPFGGTLQGIGAASWAYLG----KSPANLSYS---EAAMLAVLPQAPSRLRPDRWPERAEAARNKVL 223
Cdd:PRK13481 132 YSKNEILSFYLNNIYFGDNQYTLEGAANHYFGttvnKNSTTMSHItvlQSAILASKVNAPSVYNINDMSENFTQRVSTNL 211
|
170
....*....|....*..
gi 16130444 224 ERMAVQGVWSREQVKES 240
Cdd:PRK13481 212 EKMKQQNYINETQYQQA 228
|
|
| pbp2_mrdA |
TIGR03423 |
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ... |
272-422 |
5.44e-06 |
|
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 274573 [Multi-domain] Cd Length: 592 Bit Score: 49.83 E-value: 5.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 272 ITTTLDAGLQRRLEElaqnwkgRLPPRSSlAMIVVDHTDMRVRGWVGS--------VD---------LNDDSRFGhvdMV 334
Cdd:TIGR03423 228 LVLTIDARLQQAAEK-------ALGGRRG-AVVVMDPRTGEILAMVSTpsfdpnlfVDgisskdykaLLNDPDRP---LL 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130444 335 N-SIRS---PGSVLKPFVYGLALDEGLIHPASLLQD-----VPRRTgdYRpgNFDSGFHGPISMSEALVRSLNLPAVQVL 405
Cdd:TIGR03423 297 NrAIQGvypPGSTFKPVVALAALEEGVITPETRIYCpgyfqLGGRR--FR--CWKRGGHGRVDLRKAIEESCDVYFYQLA 372
|
170
....*....|....*..
gi 16130444 406 EAYGPKRFAAKLRNVGL 422
Cdd:TIGR03423 373 LRLGIDKIAEYAKRFGF 389
|
|
| |
