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Conserved domains on  [gi|16130547|ref|NP_417118|]
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protein YfjM [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

HNH endonuclease family protein( domain architecture ID 1640)

HNH endonuclease family protein, similar to Physarum polycephalum intron-encoded endonuclease I-Ppoi which mediates the mobility of intron 3 in the ribosomal DNA

EC:  3.1.-.-
Gene Ontology:  GO:0004519

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF1524 super family cl47973
Protein of unknown function (DUF1524); This family of uncharacterized proteins contain a ...
 5-74 1.91e-04

Protein of unknown function (DUF1524); This family of uncharacterized proteins contain a conserved HXXP motif. A similar motif is seen in protein families in the His-Me finger endonuclease superfamily which suggests this family of proteins may also act as endonucleases.


The actual alignment was detected with superfamily member pfam07510:

Pssm-ID: 462188 [Multi-domain]  Cd Length: 141  Bit Score: 37.44  E-value: 1.91e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130547     5 VHRFGNLFLISPSSNSILSNYSPADKKKFYvetERAESPKQAIMMSYKEWGPDgqginNIESHEHAMLTL 74
Cdd:pfam07510  80 VNDLGNLTLLTGSLNSAASNKDFLPKRKAY---EKSCLYLTRQLAVKDKWNEE-----VIEARQEALAKV 141
 
Name Accession Description Interval E-value
DUF1524 pfam07510
Protein of unknown function (DUF1524); This family of uncharacterized proteins contain a ...
 5-74 1.91e-04

Protein of unknown function (DUF1524); This family of uncharacterized proteins contain a conserved HXXP motif. A similar motif is seen in protein families in the His-Me finger endonuclease superfamily which suggests this family of proteins may also act as endonucleases.


Pssm-ID: 462188 [Multi-domain]  Cd Length: 141  Bit Score: 37.44  E-value: 1.91e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130547     5 VHRFGNLFLISPSSNSILSNYSPADKKKFYvetERAESPKQAIMMSYKEWGPDgqginNIESHEHAMLTL 74
Cdd:pfam07510  80 VNDLGNLTLLTGSLNSAASNKDFLPKRKAY---EKSCLYLTRQLAVKDKWNEE-----VIEARQEALAKV 141
 
Name Accession Description Interval E-value
DUF1524 pfam07510
Protein of unknown function (DUF1524); This family of uncharacterized proteins contain a ...
 5-74 1.91e-04

Protein of unknown function (DUF1524); This family of uncharacterized proteins contain a conserved HXXP motif. A similar motif is seen in protein families in the His-Me finger endonuclease superfamily which suggests this family of proteins may also act as endonucleases.


Pssm-ID: 462188 [Multi-domain]  Cd Length: 141  Bit Score: 37.44  E-value: 1.91e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130547     5 VHRFGNLFLISPSSNSILSNYSPADKKKFYvetERAESPKQAIMMSYKEWGPDgqginNIESHEHAMLTL 74
Cdd:pfam07510  80 VNDLGNLTLLTGSLNSAASNKDFLPKRKAY---EKSCLYLTRQLAVKDKWNEE-----VIEARQEALAKV 141
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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