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Conserved domains on  [gi|90111470|ref|NP_417120|]
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antitoxin RnlB [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

type II toxin-antitoxin system RnlB family antitoxin( domain architecture ID 11239877)

type II toxin-antitoxin (TA) system RnlB family antitoxin similar to Escherichia coli RnlB, the antitoxin component of the RnlA-RnlB TA system that plays a role in bacteriophage resistance; inhibits the endonuclease activity of cognate toxin RnlA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RnlB_antitoxin pfam15933
Antitoxin to bacterial toxin RNase LS or RnlA; RnlB_antitoxin, formerly known as yfjO, has ...
 14-112 1.23e-32

Antitoxin to bacterial toxin RNase LS or RnlA; RnlB_antitoxin, formerly known as yfjO, has been found to be the antidote protein to RNase LS or RnlA in E. coli. Bacterial toxin-antitoxin systems consist of a stable toxin and an unstable antitoxin. In this case, a novel type II system, RnlA is the stable toxin that causes inhibition of cell growth and rapidly degrades T4 late mRNAs to prevent their expression, and this is neutralized by the activity of the unstable antitoxin RnlB.


:

Pssm-ID: 406375  Cd Length: 94  Bit Score: 110.08  E-value: 1.23e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111470    14 KAVVMATGFENPLSSVNEIETKLSALlgsETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKIIDEqdVPTHILSK 93
Cdd:pfam15933   1 KILVISTSYESPIEYLTELENDLQKN---ETKGEVLFDLLLSNGMSRNRFYKAFFDGVKFNRNSLKKVSN--VDEELLSA 75

                          90
                  ....*....|....*....
gi 90111470    94 LTFTLRNHPEYLEASVLSP 112
Cdd:pfam15933  76 SSKFLANNPDVLENSILSK 94
 
Name Accession Description Interval E-value
RnlB_antitoxin pfam15933
Antitoxin to bacterial toxin RNase LS or RnlA; RnlB_antitoxin, formerly known as yfjO, has ...
 14-112 1.23e-32

Antitoxin to bacterial toxin RNase LS or RnlA; RnlB_antitoxin, formerly known as yfjO, has been found to be the antidote protein to RNase LS or RnlA in E. coli. Bacterial toxin-antitoxin systems consist of a stable toxin and an unstable antitoxin. In this case, a novel type II system, RnlA is the stable toxin that causes inhibition of cell growth and rapidly degrades T4 late mRNAs to prevent their expression, and this is neutralized by the activity of the unstable antitoxin RnlB.


Pssm-ID: 406375  Cd Length: 94  Bit Score: 110.08  E-value: 1.23e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111470    14 KAVVMATGFENPLSSVNEIETKLSALlgsETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKIIDEqdVPTHILSK 93
Cdd:pfam15933   1 KILVISTSYESPIEYLTELENDLQKN---ETKGEVLFDLLLSNGMSRNRFYKAFFDGVKFNRNSLKKVSN--VDEELLSA 75

                          90
                  ....*....|....*....
gi 90111470    94 LTFTLRNHPEYLEASVLSP 112
Cdd:pfam15933  76 SSKFLANNPDVLENSILSK 94
 
Name Accession Description Interval E-value
RnlB_antitoxin pfam15933
Antitoxin to bacterial toxin RNase LS or RnlA; RnlB_antitoxin, formerly known as yfjO, has ...
 14-112 1.23e-32

Antitoxin to bacterial toxin RNase LS or RnlA; RnlB_antitoxin, formerly known as yfjO, has been found to be the antidote protein to RNase LS or RnlA in E. coli. Bacterial toxin-antitoxin systems consist of a stable toxin and an unstable antitoxin. In this case, a novel type II system, RnlA is the stable toxin that causes inhibition of cell growth and rapidly degrades T4 late mRNAs to prevent their expression, and this is neutralized by the activity of the unstable antitoxin RnlB.


Pssm-ID: 406375  Cd Length: 94  Bit Score: 110.08  E-value: 1.23e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111470    14 KAVVMATGFENPLSSVNEIETKLSALlgsETTGEILFDLLCANGPEWNRFVTLEMKYGRIMLDTAKIIDEqdVPTHILSK 93
Cdd:pfam15933   1 KILVISTSYESPIEYLTELENDLQKN---ETKGEVLFDLLLSNGMSRNRFYKAFFDGVKFNRNSLKKVSN--VDEELLSA 75

                          90
                  ....*....|....*....
gi 90111470    94 LTFTLRNHPEYLEASVLSP 112
Cdd:pfam15933  76 SSKFLANNPDVLENSILSK 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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