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Conserved domains on  [gi|16130712|ref|NP_417285|]
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DNA-binding transcriptional activator FucR [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

PRK10411 family protein( domain architecture ID 11484699)

PRK10411 family protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK10411 PRK10411
L-fucose operon activator;
1-240 5.43e-177

L-fucose operon activator;


:

Pssm-ID: 236684 [Multi-domain]  Cd Length: 240  Bit Score: 485.46  E-value: 5.43e-177
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130712    1 MKAARQQAIVDLLLNHTSLTTEALSEQLKVSKETIRRDLNELQTQGKILRNHGRAKYIHRQNQDSGDPFHIRLKSHYAHK 80
Cdd:PRK10411   1 MKAARQQAIVDLLLNHTSLTTEALAEQLNVSKETIRRDLNELQTQGKILRNHGRAKYIHRQNQDSGDPFHIRLKSHYAHK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130712   81 ADIAREALAWIEEGMVIALDASSTCWYLARQLPDINIQVFTNSHPICHELGKRERIQLISSGGTLERKYGCYVNPSLISQ 160
Cdd:PRK10411  81 ADIAREALAWIEEGMVIALDASSTCWYLARQLPDINIQVFTNSHPICQELGKRERIQLISSGGTLERKYGCYVNPSLISQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130712  161 LKSLEIDLFIFSCEGIDSSGALWDSNAINADYKSMLLKRAAQSLLLIDKSKFNRSGEARIGHLDEVTHIISDERQVATSL 240
Cdd:PRK10411 161 LKSLEIDLFIFSCEGIDSSGALWDSNAINADYKSMLLKRAAQSLLLIDKSKFNRSGEARIGHLDEVTHIISDERQVATSL 240
 
Name Accession Description Interval E-value
PRK10411 PRK10411
L-fucose operon activator;
1-240 5.43e-177

L-fucose operon activator;


Pssm-ID: 236684 [Multi-domain]  Cd Length: 240  Bit Score: 485.46  E-value: 5.43e-177
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130712    1 MKAARQQAIVDLLLNHTSLTTEALSEQLKVSKETIRRDLNELQTQGKILRNHGRAKYIHRQNQDSGDPFHIRLKSHYAHK 80
Cdd:PRK10411   1 MKAARQQAIVDLLLNHTSLTTEALAEQLNVSKETIRRDLNELQTQGKILRNHGRAKYIHRQNQDSGDPFHIRLKSHYAHK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130712   81 ADIAREALAWIEEGMVIALDASSTCWYLARQLPDINIQVFTNSHPICHELGKRERIQLISSGGTLERKYGCYVNPSLISQ 160
Cdd:PRK10411  81 ADIAREALAWIEEGMVIALDASSTCWYLARQLPDINIQVFTNSHPICQELGKRERIQLISSGGTLERKYGCYVNPSLISQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130712  161 LKSLEIDLFIFSCEGIDSSGALWDSNAINADYKSMLLKRAAQSLLLIDKSKFNRSGEARIGHLDEVTHIISDERQVATSL 240
Cdd:PRK10411 161 LKSLEIDLFIFSCEGIDSSGALWDSNAINADYKSMLLKRAAQSLLLIDKSKFNRSGEARIGHLDEVTHIISDERQVATSL 240
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
1-233 2.36e-72

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 221.16  E-value: 2.36e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130712   1 MKAARQQAIVDLLLNHTSLTTEALSEQLKVSKETIRRDLNELQTQGKILRNHGRAKYIHRQNQDSgdPFHIRLKSHYAHK 80
Cdd:COG1349   2 LAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAEP--PFAERETLNAEEK 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130712  81 ADIAREALAWIEEGMVIALDASSTCWYLARQLPD-INIQVFTNSHPICHELGKRERIQLISSGGTLERKYGCYVNPSLIS 159
Cdd:COG1349  80 RAIARAAASLIEDGDTIFLDAGTTTLALARALPDrRNLTVVTNSLNIANELAERPNIEVILLGGELRPSSGSLVGPLAEE 159
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16130712 160 QLKSLEIDLFIFSCEGIDSSGALWDSNAINADYKSMLLKRAAQSLLLIDKSKFNRSGEARIGHLDEVTHIISDE 233
Cdd:COG1349 160 ALRRFRADKAFLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDA 233
DeoRC pfam00455
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ...
75-233 2.41e-57

DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395365  Cd Length: 160  Bit Score: 179.63  E-value: 2.41e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130712    75 SHYAHKADIAREALAWIEEGMVIALDASSTCWYLARQLPDI-NIQVFTNSHPICHELGKRERIQLISSGGTLERKYGCYV 153
Cdd:pfam00455   1 ENAEEKRRIAKAAASLIEDGDTIFLDAGTTTLELARALPDRrNLTVITNSLNIANELSEKPDIEVILLGGEVRPKTGAFV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130712   154 NPSLISQLKSLEIDLFIFSCEGIDSSGALWDSNAINADYKSMLLKRAAQSLLLIDKSKFNRSGEARIGHLDEVTHIISDE 233
Cdd:pfam00455  81 GPLAEEFLRQFNVDKAFIGANGIDLEGGLTTSDEEEAEVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALITDK 160
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
5-57 8.63e-17

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 71.87  E-value: 8.63e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 16130712      5 RQQAIVDLLLNHTSLTTEALSEQLKVSKETIRRDLNELQTQGKILRNHGRAKY 57
Cdd:smart00420   1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGAVS 53
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
19-54 2.05e-03

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 35.89  E-value: 2.05e-03
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 16130712  19 LTTE-ALSEQLKVSKETIRRDLNELQTQGKILRNHGR 54
Cdd:cd07377  25 LPSErELAEELGVSRTTVREALRELEAEGLVERRPGR 61
 
Name Accession Description Interval E-value
PRK10411 PRK10411
L-fucose operon activator;
1-240 5.43e-177

L-fucose operon activator;


Pssm-ID: 236684 [Multi-domain]  Cd Length: 240  Bit Score: 485.46  E-value: 5.43e-177
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130712    1 MKAARQQAIVDLLLNHTSLTTEALSEQLKVSKETIRRDLNELQTQGKILRNHGRAKYIHRQNQDSGDPFHIRLKSHYAHK 80
Cdd:PRK10411   1 MKAARQQAIVDLLLNHTSLTTEALAEQLNVSKETIRRDLNELQTQGKILRNHGRAKYIHRQNQDSGDPFHIRLKSHYAHK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130712   81 ADIAREALAWIEEGMVIALDASSTCWYLARQLPDINIQVFTNSHPICHELGKRERIQLISSGGTLERKYGCYVNPSLISQ 160
Cdd:PRK10411  81 ADIAREALAWIEEGMVIALDASSTCWYLARQLPDINIQVFTNSHPICQELGKRERIQLISSGGTLERKYGCYVNPSLISQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130712  161 LKSLEIDLFIFSCEGIDSSGALWDSNAINADYKSMLLKRAAQSLLLIDKSKFNRSGEARIGHLDEVTHIISDERQVATSL 240
Cdd:PRK10411 161 LKSLEIDLFIFSCEGIDSSGALWDSNAINADYKSMLLKRAAQSLLLIDKSKFNRSGEARIGHLDEVTHIISDERQVATSL 240
GlpR COG1349
DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, ...
1-233 2.36e-72

DNA-binding transcriptional regulator of sugar metabolism, DeoR/GlpR family [Transcription, Carbohydrate transport and metabolism];


Pssm-ID: 440960 [Multi-domain]  Cd Length: 254  Bit Score: 221.16  E-value: 2.36e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130712   1 MKAARQQAIVDLLLNHTSLTTEALSEQLKVSKETIRRDLNELQTQGKILRNHGRAKYIHRQNQDSgdPFHIRLKSHYAHK 80
Cdd:COG1349   2 LAEERRQKILELLRERGRVSVEELAERLGVSEETIRRDLAELEEQGLLRRVHGGAVLVSSAAAEP--PFAERETLNAEEK 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130712  81 ADIAREALAWIEEGMVIALDASSTCWYLARQLPD-INIQVFTNSHPICHELGKRERIQLISSGGTLERKYGCYVNPSLIS 159
Cdd:COG1349  80 RAIARAAASLIEDGDTIFLDAGTTTLALARALPDrRNLTVVTNSLNIANELAERPNIEVILLGGELRPSSGSLVGPLAEE 159
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16130712 160 QLKSLEIDLFIFSCEGIDSSGALWDSNAINADYKSMLLKRAAQSLLLIDKSKFNRSGEARIGHLDEVTHIISDE 233
Cdd:COG1349 160 ALRRFRADKAFLGASGIDAEGGLTTFDEEEAEVKRAMIEAARRVILLADSSKFGRRALARVAPLSEIDVLITDA 233
DeoRC pfam00455
DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive ...
75-233 2.41e-57

DeoR C terminal sensor domain; The sensor domains of the DeoR are catalytically inactive versions of the ISOCOT fold, but retain the substrate binding site. DeorC senses diverse sugar derivatives such as deoxyribose nucleoside (DeoR), tagatose phosphate (LacR), galactosamine (AgaR), myo-inositol (Bacillus IolR) and L-ascorbate (UlaR). It can also bind L-ascorbate 6-phosphate, agrocinopines, sn-glycerol 3-phosphate, and sulfoquinovose (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395365  Cd Length: 160  Bit Score: 179.63  E-value: 2.41e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130712    75 SHYAHKADIAREALAWIEEGMVIALDASSTCWYLARQLPDI-NIQVFTNSHPICHELGKRERIQLISSGGTLERKYGCYV 153
Cdd:pfam00455   1 ENAEEKRRIAKAAASLIEDGDTIFLDAGTTTLELARALPDRrNLTVITNSLNIANELSEKPDIEVILLGGEVRPKTGAFV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130712   154 NPSLISQLKSLEIDLFIFSCEGIDSSGALWDSNAINADYKSMLLKRAAQSLLLIDKSKFNRSGEARIGHLDEVTHIISDE 233
Cdd:pfam00455  81 GPLAEEFLRQFNVDKAFIGANGIDLEGGLTTSDEEEAEVKRAMIEAARRVILLADSSKFGKRAFARFAPLEDIDALITDK 160
PRK10906 PRK10906
DeoR/GlpR family transcriptional regulator;
5-233 6.47e-25

DeoR/GlpR family transcriptional regulator;


Pssm-ID: 182827 [Multi-domain]  Cd Length: 252  Bit Score: 98.78  E-value: 6.47e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130712    5 RQQAIVDLLLNHTSLTTEALSEQLKVSKETIRRDLNELQTQGKILRNHGRAKYihrQNQDSGDPFHIRLKSHYAHKADIA 84
Cdd:PRK10906   6 RHDAIIELVKQQGYVSTEELVEHFSVSPQTIRRDLNDLAEQNKILRHHGGAAL---PSSSVNTPWHDRKATQTEEKERIA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130712   85 REALAWIEEGMVIALDASSTCWYLARQLPD-INIQVFTNSHPICHELGKRERIQLISSGGTLERKYGCYVNPSLISQLKS 163
Cdd:PRK10906  83 RKVASQIPNGATLFIDIGTTPEAVAHALLNhSNLRIVTNNLNVANTLMAKEDFRIILAGGELRSRDGGIIGEATLDFISQ 162
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130712  164 LEIDLFIFSCEGIDSSGALWDSNAINADYKSMLLKRAAQSLLLIDKSKFNRSGEARIGHLDEVTHIISDE 233
Cdd:PRK10906 163 FRLDFGILGISGIDSDGSLLEFDYHEVRTKRAIIENSRHVMLVVDHSKFGRNAMVNMGSISMVDAVYTDQ 232
srlR PRK10434
DNA-binding transcriptional repressor;
1-233 2.54e-21

DNA-binding transcriptional repressor;


Pssm-ID: 182457 [Multi-domain]  Cd Length: 256  Bit Score: 89.36  E-value: 2.54e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130712    1 MKA-ARQQAIVDLLLNHTSLTTEALSEQLKVSKETIRRDLNELQTQGKILRNHGRAKYihrqNQDSGDPfHIRLKSHY-- 77
Cdd:PRK10434   1 MKPrQRQAAILEYLQKQGKTSVEELAQYFDTTGTTIRKDLVILEHAGTVIRTYGGVVL----NKEESDP-PIDHKTLInt 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130712   78 AHKADIAREALAWIEEGMVIALDASSTCW----YLARQlpdINIQVFTNSHPICHELGKRERIQ-LISSGGTLERKYGCY 152
Cdd:PRK10434  76 HKKELIAEAAVSLIHDGDSIILDAGSTVLqmvpLLSRF---NNITVMTNSLHIVNALSELDNEQtILMPGGTFRKKSASF 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130712  153 VNPSLISQLKSLEID-LFIfSCEGIDSSGALWDSNAINADYKSMlLKRAAQSLLLIDKSKFNRSGEARIGHLDEVTHIIS 231
Cdd:PRK10434 153 HGQLAENAFEHFTFDkLFI-GTDGIDLNAGVTTFNEVYTVSKAM-CNAAREIILMADSSKFGRKSPNVVCSLEKVDKLIT 230

                 ..
gi 16130712  232 DE 233
Cdd:PRK10434 231 DA 232
PRK09802 PRK09802
DeoR family transcriptional regulator;
5-240 1.46e-19

DeoR family transcriptional regulator;


Pssm-ID: 182086 [Multi-domain]  Cd Length: 269  Bit Score: 84.91  E-value: 1.46e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130712    5 RQQAIVDLLLNHTSLTTEALSEQLKVSKETIRRDLNELQTQGKILRNHGRAkYIHRQNQDSGDPfHIRLKS--HYAHKAD 82
Cdd:PRK09802  18 RREQIIQRLRQQGSVQVNDLSALYGVSTVTIRNDLAFLEKQGIAVRAYGGA-LICDSTTPSVEP-SVEDKSalNTAMKRS 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130712   83 IAREALAWIEEGMVIALDASSTCWYLARQLPD-INIQVFTNSHPICHELGKRERIQLISSGGTLERKYGCYVNPSLISQL 161
Cdd:PRK09802  96 VAKAAVELIQPGHRVILDSGTTTFEIARLMRKhTDVIAMTNGMNVANALLEAEGVELLMTGGHLRRQSQSFYGDQAEQSL 175
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 16130712  162 KSLEIDLFIFSCEGIDSSGALWDSNAINADYKSMLLKRAAQSLLLIDKSKFNRSGEARIGHLDEVTHIISDERQVATSL 240
Cdd:PRK09802 176 QNYHFDMLFLGVDAIDLERGVSTHNEDEARLNRRMCEVAERIIVVTDSSKFNRSSLHKIIDTQRIDMIIVDEGIPADSL 254
HTH_DeoR pfam08220
DeoR-like helix-turn-helix domain;
5-61 9.20e-19

DeoR-like helix-turn-helix domain;


Pssm-ID: 285436 [Multi-domain]  Cd Length: 57  Bit Score: 77.30  E-value: 9.20e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 16130712     5 RQQAIVDLLLNHTSLTTEALSEQLKVSKETIRRDLNELQTQGKILRNHGRAKYIHRQ 61
Cdd:pfam08220   1 RIQQILELLKQQGTLSVEELAELLGVSEMTIRRDLNELEEQGLLTRTHGGAVSNSST 57
HTH_DEOR smart00420
helix_turn_helix, Deoxyribose operon repressor;
5-57 8.63e-17

helix_turn_helix, Deoxyribose operon repressor;


Pssm-ID: 197714 [Multi-domain]  Cd Length: 53  Bit Score: 71.87  E-value: 8.63e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 16130712      5 RQQAIVDLLLNHTSLTTEALSEQLKVSKETIRRDLNELQTQGKILRNHGRAKY 57
Cdd:smart00420   1 RQQQILELLAQQGKVSVEELAELLGVSEMTIRRDLNKLEEQGLLTRVHGGAVS 53
PRK13509 PRK13509
HTH-type transcriptional regulator UlaR;
3-211 1.45e-16

HTH-type transcriptional regulator UlaR;


Pssm-ID: 184100 [Multi-domain]  Cd Length: 251  Bit Score: 76.20  E-value: 1.45e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130712    3 AARQQAIVDLLLNHTSLTTEALSEQLKVSKETIRRDLNELQTQGKI--LRNHgrAKYIHrQNQDSGDPFHIRLKSHYAHK 80
Cdd:PRK13509   4 AQRHQILLELLAQLGFVTVEKVIERLGISPATARRDINKLDESGKLkkVRNG--AEAIT-QQRPRWTPMNIHQAQNHDEK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130712   81 ADIAREALAWIEEGMVIALDASSTCWYLARQLPDINIQVFTNSHPICHELGKRERIQLISSGGTLERKYGCYVNPSliSQ 160
Cdd:PRK13509  81 VRIAKAASQLCNPGESVVINCGSTAFLLGRELCGKPVQIITNYLPLANYLIDQEHDSVIIMGGQYNKSQSITLSPQ--GS 158
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 16130712  161 LKSLEIDLFIF-SCEGIDSSGaLWDSNAINADYKSMLLKRAAQSLLLIDKSK 211
Cdd:PRK13509 159 ENSLYAGHWMFtSGKGLTADG-LYKTDMLTAMAEQKMLSVVGKLVVLVDSSK 209
YobV COG2378
Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains ...
1-46 5.38e-08

Predicted DNA-binding transcriptional regulator YobV, contains HTH and WYL domains [Transcription];


Pssm-ID: 441945 [Multi-domain]  Cd Length: 314  Bit Score: 52.39  E-value: 5.38e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 16130712   1 MKAARQQAIVDLLLNHTSLTTEALSEQLKVSKETIRRDLNELQTQG 46
Cdd:COG2378   2 SRLERLLALLQLLQSRRGVTAAELAERLEVSERTIYRDIDALRELG 47
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
7-58 2.22e-04

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 38.32  E-value: 2.22e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 16130712      7 QAIVDLLLNH-TSLTTE-ALSEQLKVSKETIRRDLNELQTQGKILRNHGRAKYI 58
Cdd:smart00345   7 EDIVSGELRPgDKLPSErELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
HTH_11 pfam08279
HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.
7-49 2.35e-04

HTH domain; This family includes helix-turn-helix domains in a wide variety of proteins.


Pssm-ID: 429896 [Multi-domain]  Cd Length: 52  Bit Score: 37.80  E-value: 2.35e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 16130712     7 QAIVDLLLNHTS-LTTEALSEQLKVSKETIRRDLNELQTQGKIL 49
Cdd:pfam08279   1 LQILQLLLEARGpISGQELAEKLGVSRRTIRRDIKILEELGVPI 44
ArgR COG1438
Arginine repressor [Transcription];
1-97 2.79e-04

Arginine repressor [Transcription];


Pssm-ID: 441047  Cd Length: 152  Bit Score: 40.11  E-value: 2.79e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130712   1 MKAARQQAIVDLLLNHTSLTTEALSEQLK-----VSKETIRRDLNELQTqGKILRNHGRAKY-IHRQNQDSGDPfhiRLK 74
Cdd:COG1438   2 KKAARQAKIKEIISEEEIETQEELVELLKeegfnVTQATVSRDLKELGL-VKVPNADGGYVYaLPEEGGPNPEE---RLK 77
                        90       100
                ....*....|....*....|....*
gi 16130712  75 ShyahkadIAREALAWIE--EGMVI 97
Cdd:COG1438  78 R-------LLRELVVSIDhsGNLVV 95
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
7-58 3.73e-04

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 37.59  E-value: 3.73e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 16130712     7 QAIVDLLLN-----HTSLTTE-ALSEQLKVSKETIRRDLNELQTQGKILRNHGRAKYI 58
Cdd:pfam00392   7 ARLREDILSgrlrpGDKLPSErELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
PRK04424 PRK04424
transcription factor FapR;
2-42 1.24e-03

transcription factor FapR;


Pssm-ID: 179847 [Multi-domain]  Cd Length: 185  Bit Score: 38.65  E-value: 1.24e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 16130712    2 KAARQQAIVDLLLNHTSLTTEALSEQLKVSKETIRRDLNEL 42
Cdd:PRK04424   5 KKERQKALQELIEENPFITDEELAEKFGVSIQTIRLDRMEL 45
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
23-54 1.60e-03

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 38.69  E-value: 1.60e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 16130712  23 ALSEQLKVSKETIRRDLNELQTQGKILRNHGR 54
Cdd:COG2188  34 ELAEEFGVSRMTVRKALDELVEEGLLERRQGR 65
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
19-54 2.05e-03

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 35.89  E-value: 2.05e-03
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 16130712  19 LTTE-ALSEQLKVSKETIRRDLNELQTQGKILRNHGR 54
Cdd:cd07377  25 LPSErELAEELGVSRTTVREALRELEAEGLVERRPGR 61
HTH_ICLR smart00346
helix_turn_helix isocitrate lyase regulation;
4-93 4.29e-03

helix_turn_helix isocitrate lyase regulation;


Pssm-ID: 214629 [Multi-domain]  Cd Length: 91  Bit Score: 35.64  E-value: 4.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130712      4 ARQQAIVDLLLN-HTSLTTEALSEQLKVSKETIRRDLNELQTQGKILRNHGRAKYihrqnqdSGDPFHIRLKSHYAHKAD 82
Cdd:smart00346   5 ERGLAVLRALAEePGGLTLAELAERLGLSKSTAHRLLNTLQELGYVEQDGQNGRY-------RLGPKVLELGQSYLSSLD 77
                           90
                   ....*....|.
gi 16130712     83 IAREALAWIEE 93
Cdd:smart00346  78 LREVAKPVLEE 88
BglG COG3711
Transcriptional antiterminator [Transcription];
12-53 4.61e-03

Transcriptional antiterminator [Transcription];


Pssm-ID: 442925 [Multi-domain]  Cd Length: 618  Bit Score: 37.92  E-value: 4.61e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|..
gi 16130712  12 LLLNHTSLTTEALSEQLKVSKETIRRDLNELqtqGKILRNHG 53
Cdd:COG3711   5 LLKNNNVVTAKELAKKLNVSERTIRYDIKKI---NEWLKKNG 43
Tau138_eWH cd16169
extended winged-helix domain of tau138 and related proteins; Tau138 is one of three subunits ...
5-48 4.87e-03

extended winged-helix domain of tau138 and related proteins; Tau138 is one of three subunits of the tauB subcomplex of yeast transcription factor IIIC. This extended winged-helix domain of tau138 appears to interact with the TPR (tetratricopeptide repeat) array of tauA subunit tau131, and may therefore play a role in linking tauA, tauB, and TFIIIB to regulate the formation of the RNA polymerase III pre-initiation complex.


Pssm-ID: 320085  Cd Length: 97  Bit Score: 35.64  E-value: 4.87e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 16130712   5 RQQAIVDLL------LNHTSLTTEALSEQLKVS----KETIRRDLNELQTQGKI 48
Cdd:cd16169   7 RENEILEVLkelggvVNLEKKFLEEHEKLLGSLtrmdKKTLKRDLNKLEEEGKL 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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