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Conserved domains on  [gi|145698309|ref|NP_417516|]
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IS2 insertion element repressor InsA [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

MarR family transcriptional regulator; ArsR family transcriptional regulator( domain architecture ID 10013221)

MarR family transcriptional regulator such as the multiple antibiotic resistance transcriptional regulator MarR, the repressor of the marRAB operon involved in the activation of both antibiotic resistance and oxidative stress genes| ArsR family transcriptional regulator containing an N-terminal ArsR family helix-turn-helix (HTH) DNA-binding domain and a C-terminal SAM-dependent methyltransferase domain, may function as a metalloregulatory transcriptional repressor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK09413 PRK09413
IS2 repressor TnpA; Reviewed
 1-121 2.87e-72

IS2 repressor TnpA; Reviewed


:

Pssm-ID: 181833  Cd Length: 121  Bit Score: 211.20  E-value: 2.87e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698309   1 MIDVLGPEKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASELAAAMKQI 80
Cdd:PRK09413   1 MIDVLGPEKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASELAAAMKQI 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 145698309  81 KELQRLLGKKTMENELLKEAVEYGRAKKWIAHAPLLPGDGE 121
Cdd:PRK09413  81 KELQRLLGKKTMENELLKEAVEYGRAKKWIAHAPLLPGDGE 121
 
Name Accession Description Interval E-value
PRK09413 PRK09413
IS2 repressor TnpA; Reviewed
 1-121 2.87e-72

IS2 repressor TnpA; Reviewed


Pssm-ID: 181833  Cd Length: 121  Bit Score: 211.20  E-value: 2.87e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698309   1 MIDVLGPEKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASELAAAMKQI 80
Cdd:PRK09413   1 MIDVLGPEKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASELAAAMKQI 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 145698309  81 KELQRLLGKKTMENELLKEAVEYGRAKKWIAHAPLLPGDGE 121
Cdd:PRK09413  81 KELQRLLGKKTMENELLKEAVEYGRAKKWIAHAPLLPGDGE 121
transpos_IS3 NF033516
IS3 family transposase;
16-108 1.10e-22

IS3 family transposase;


Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 90.32  E-value: 1.10e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698309  16 QEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVaAGEQVVPaseLAAAMKQIKELQRLLGKKTMENE 95
Cdd:NF033516   1 EFKLEAVREVLEGGKSVAEVARELGISPSTLYRWRKKYRGGGEAAD-AGRLKEL---LTPEEEENRRLKRELAELRLENE 76

                         90
                 ....*....|...
gi 145698309  96 LLKEAVEYGRAKK 108
Cdd:NF033516  77 ILKKARKLLRPAV 89
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
7-103 9.83e-22

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 82.28  E-value: 9.83e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698309   7 PEKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASElaaamkQIKELQRL 86
Cdd:COG2963    2 SKKRRRYSPEFKAEAVRLVLEGGASVAEVARELGISPSTLYRWVRQYREGGLGGFPGDGRTTPEQA------EIRRLRKE 75

                         90
                 ....*....|....*..
gi 145698309  87 LGKKTMENELLKEAVEY 103
Cdd:COG2963   76 LRRLEMENDILKKAAAL 92
HTH_Tnp_1 pfam01527
Transposase; Transposase proteins are necessary for efficient DNA transposition. This family ...
 8-87 1.07e-15

Transposase; Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.


Pssm-ID: 426308 [Multi-domain]  Cd Length: 75  Bit Score: 66.22  E-value: 1.07e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698309    8 EKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAageqvvpASELAAAMKQIKELQRLL 87
Cdd:pfam01527   2 KKRRRFSEEFKLRAVKEVLEPGRTVKEVARRHGVSPNTLYQWRRQYEGGMGASPA-------RPRLTALEEENRRLKREL 74
 
Name Accession Description Interval E-value
PRK09413 PRK09413
IS2 repressor TnpA; Reviewed
 1-121 2.87e-72

IS2 repressor TnpA; Reviewed


Pssm-ID: 181833  Cd Length: 121  Bit Score: 211.20  E-value: 2.87e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698309   1 MIDVLGPEKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASELAAAMKQI 80
Cdd:PRK09413   1 MIDVLGPEKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASELAAAMKQI 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 145698309  81 KELQRLLGKKTMENELLKEAVEYGRAKKWIAHAPLLPGDGE 121
Cdd:PRK09413  81 KELQRLLGKKTMENELLKEAVEYGRAKKWIAHAPLLPGDGE 121
transpos_IS3 NF033516
IS3 family transposase;
16-108 1.10e-22

IS3 family transposase;


Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 90.32  E-value: 1.10e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698309  16 QEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVaAGEQVVPaseLAAAMKQIKELQRLLGKKTMENE 95
Cdd:NF033516   1 EFKLEAVREVLEGGKSVAEVARELGISPSTLYRWRKKYRGGGEAAD-AGRLKEL---LTPEEEENRRLKRELAELRLENE 76

                         90
                 ....*....|...
gi 145698309  96 LLKEAVEYGRAKK 108
Cdd:NF033516  77 ILKKARKLLRPAV 89
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
7-103 9.83e-22

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 82.28  E-value: 9.83e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698309   7 PEKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAAGEQVVPASElaaamkQIKELQRL 86
Cdd:COG2963    2 SKKRRRYSPEFKAEAVRLVLEGGASVAEVARELGISPSTLYRWVRQYREGGLGGFPGDGRTTPEQA------EIRRLRKE 75

                         90
                 ....*....|....*..
gi 145698309  87 LGKKTMENELLKEAVEY 103
Cdd:COG2963   76 LRRLEMENDILKKAAAL 92
HTH_Tnp_1 pfam01527
Transposase; Transposase proteins are necessary for efficient DNA transposition. This family ...
 8-87 1.07e-15

Transposase; Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.


Pssm-ID: 426308 [Multi-domain]  Cd Length: 75  Bit Score: 66.22  E-value: 1.07e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 145698309    8 EKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLTAVAageqvvpASELAAAMKQIKELQRLL 87
Cdd:pfam01527   2 KKRRRFSEEFKLRAVKEVLEPGRTVKEVARRHGVSPNTLYQWRRQYEGGMGASPA-------RPRLTALEEENRRLKREL 74
HTH_28 pfam13518
Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is ...
 17-60 4.04e-03

Helix-turn-helix domain; This helix-turn-helix domain is often found in transposases and is likely to be DNA-binding.


Pssm-ID: 463908 [Multi-domain]  Cd Length: 52  Bit Score: 33.33  E-value: 4.04e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 145698309   17 EKIAIVQQSFEpGMTVSLVARQHGVAASQLFLWRKQYQEGSLTA 60
Cdd:pfam13518   1 ERLKIVLLALE-GESIKEAARLFGISRSTVYRWIRRYREGGLEG 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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