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Conserved domains on  [gi|16130978|ref|NP_417554|]
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ribosome-dependent mRNA interferase toxin HigB [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

type II toxin-antitoxin system HigB family toxin( domain architecture ID 10008707)

type II toxin-antitoxin (TA) system HigB family toxin similar to Escherichia coli mRNA interferase HigB, the toxin component of the HigB-HigA TA system; induced by amino acid starvation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HigB COG4680
mRNA-degrading endonuclease (mRNA interferase) HigB, toxic component of the HigAB ...
 2-92 1.98e-33

mRNA-degrading endonuclease (mRNA interferase) HigB, toxic component of the HigAB toxin-antitoxin module [Translation, ribosomal structure and biogenesis, Defense mechanisms];


:

Pssm-ID: 443716  Cd Length: 89  Bit Score: 111.00  E-value: 1.98e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130978   2 HLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKylDKHYVFNVGGNELRVVAMVFFESQKCY 81
Cdd:COG4680   1 RIISRKTLREFWEKHPDAEQALDAWYREAKKADWKNPADLKKTFPSADIVG--NNRVVFNIKGNKYRLIVAINYERQIVY 78

                        90
                ....*....|.
gi 16130978  82 IREVMTHKEYD 92
Cdd:COG4680  79 IKFIGTHAEYD 89
 
Name Accession Description Interval E-value
HigB COG4680
mRNA-degrading endonuclease (mRNA interferase) HigB, toxic component of the HigAB ...
 2-92 1.98e-33

mRNA-degrading endonuclease (mRNA interferase) HigB, toxic component of the HigAB toxin-antitoxin module [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443716  Cd Length: 89  Bit Score: 111.00  E-value: 1.98e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130978   2 HLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKylDKHYVFNVGGNELRVVAMVFFESQKCY 81
Cdd:COG4680   1 RIISRKTLREFWEKHPDAEQALDAWYREAKKADWKNPADLKKTFPSADIVG--NNRVVFNIKGNKYRLIVAINYERQIVY 78

                        90
                ....*....|.
gi 16130978  82 IREVMTHKEYD 92
Cdd:COG4680  79 IKFIGTHAEYD 89
HigB_toxin pfam09907
HigB_toxin, RelE-like toxic component of a toxin-antitoxin system; HigB_toxin is a family of ...
 19-92 9.74e-24

HigB_toxin, RelE-like toxic component of a toxin-antitoxin system; HigB_toxin is a family of RelE-like prokaryotic proteins that function as mRNA interferases. HigB cleaves translated mRNA only, and cleavage depended on translation of the target RNAs. HigB belongs to the RelE super-family of RNases. The toxin-antitoxin gene-pair is induced by environmental stress factors.


Pssm-ID: 462925  Cd Length: 73  Bit Score: 85.98  E-value: 9.74e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16130978    19 HKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKylDKHYVFNVGGNELRVVAMVFFESQKCYIREVMTHKEYD 92
Cdd:pfam09907   1 AEQALEAWYREVKKAEWKSPADVKAVFPSADIVG--NNRVVFNIGGNKYRLIVAIDYERQKVYIKFIGTHAEYD 72
 
Name Accession Description Interval E-value
HigB COG4680
mRNA-degrading endonuclease (mRNA interferase) HigB, toxic component of the HigAB ...
 2-92 1.98e-33

mRNA-degrading endonuclease (mRNA interferase) HigB, toxic component of the HigAB toxin-antitoxin module [Translation, ribosomal structure and biogenesis, Defense mechanisms];


Pssm-ID: 443716  Cd Length: 89  Bit Score: 111.00  E-value: 1.98e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16130978   2 HLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKylDKHYVFNVGGNELRVVAMVFFESQKCY 81
Cdd:COG4680   1 RIISRKTLREFWEKHPDAEQALDAWYREAKKADWKNPADLKKTFPSADIVG--NNRVVFNIKGNKYRLIVAINYERQIVY 78

                        90
                ....*....|.
gi 16130978  82 IREVMTHKEYD 92
Cdd:COG4680  79 IKFIGTHAEYD 89
HigB_toxin pfam09907
HigB_toxin, RelE-like toxic component of a toxin-antitoxin system; HigB_toxin is a family of ...
 19-92 9.74e-24

HigB_toxin, RelE-like toxic component of a toxin-antitoxin system; HigB_toxin is a family of RelE-like prokaryotic proteins that function as mRNA interferases. HigB cleaves translated mRNA only, and cleavage depended on translation of the target RNAs. HigB belongs to the RelE super-family of RNases. The toxin-antitoxin gene-pair is induced by environmental stress factors.


Pssm-ID: 462925  Cd Length: 73  Bit Score: 85.98  E-value: 9.74e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16130978    19 HKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKylDKHYVFNVGGNELRVVAMVFFESQKCYIREVMTHKEYD 92
Cdd:pfam09907   1 AEQALEAWYREVKKAEWKSPADVKAVFPSADIVG--NNRVVFNIGGNKYRLIVAIDYERQKVYIKFIGTHAEYD 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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