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Conserved domains on  [gi|16131029|ref|NP_417606|]
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tagatose-1,6-bisphosphate aldolase 1 [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

tagatose-bisphosphate aldolase subunit KbaY( domain architecture ID 10014070)

tagatose-bisphosphate aldolase subunit KbaY is the catalytic subunit of the tagatose-1,6-bisphosphate aldolase KbaYZ, which catalyzes the reversible aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to produce tagatose 1,6-bisphosphate (TBP)

EC:  4.1.2.40
Gene Ontology:  GO:0008270
PubMed:  11976750

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
kbaY PRK12738
tagatose-bisphosphate aldolase subunit KbaY;
1-286 0e+00

tagatose-bisphosphate aldolase subunit KbaY;


:

Pssm-ID: 183711  Cd Length: 286  Bit Score: 635.15  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029    1 MSIISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTYNMPLALH 80
Cdd:PRK12738   1 MSIISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTYNMPLALH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029   81 LDHHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAESAFLTDPQEA 160
Cdd:PRK12738  81 LDHHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAESAFLTDPQEA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029  161 KRFVELTGVDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFA 240
Cdd:PRK12738 161 KRFVELTGVDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFA 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 16131029  241 GAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANRISA 286
Cdd:PRK12738 241 GAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANRISA 286
 
Name Accession Description Interval E-value
kbaY PRK12738
tagatose-bisphosphate aldolase subunit KbaY;
1-286 0e+00

tagatose-bisphosphate aldolase subunit KbaY;


Pssm-ID: 183711  Cd Length: 286  Bit Score: 635.15  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029    1 MSIISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTYNMPLALH 80
Cdd:PRK12738   1 MSIISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTYNMPLALH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029   81 LDHHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAESAFLTDPQEA 160
Cdd:PRK12738  81 LDHHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAESAFLTDPQEA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029  161 KRFVELTGVDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFA 240
Cdd:PRK12738 161 KRFVELTGVDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFA 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 16131029  241 GAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANRISA 286
Cdd:PRK12738 241 GAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANRISA 286
tag_bisphos_ald TIGR01858
class II aldolase, tagatose bisphosphate family; This model describes tagatose-1, ...
 3-284 0e+00

class II aldolase, tagatose bisphosphate family; This model describes tagatose-1,6-bisphosphate aldolases, and perhaps other closely related class II aldolases. This tetrameric, Zn2+-dependent enzyme is related to the class II fructose bisphosphate aldolase; fructose 1,6-bisphosphate and tagatose 1,6 bisphosphate differ only in chirality at C4.


Pssm-ID: 130917  Cd Length: 282  Bit Score: 541.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029     3 IISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTYNMPLALHLD 82
Cdd:TIGR01858   1 IVSTKYMLQDAQAGGYAVPAFNIHNLETIQAVVETAAEMRSPVILAGTPGTFKHAGTEYIVALCSAASTTYNMPLALHLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029    83 HHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAESAFLTDPQEAKR 162
Cdd:TIGR01858  81 HHESLDDIRQKVHAGVRSAMIDGSHFPFAQNVKLVKEVVDFCHRQDCSVEAELGRLGGVEDDLSVDEEDALYTDPQEAKE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029   163 FVELTGVDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFAGA 242
Cdd:TIGR01858 161 FVEATGVDSLAVAIGTAHGLYKKTPKLDFDRLAEIREVVDVPLVLHGASDVPDEDVRRTIELGICKVNVATELKIAFSGA 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 16131029   243 VKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANRI 284
Cdd:TIGR01858 241 VKAYFAENPQANDPRYYMRPGKDAMKKVVRNKINVCGSAGRA 282
FTBP_aldolase_II cd00453
Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1, ...
 6-282 6.50e-161

Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to yield fructose-1,6-bisphosphate. TBP-aldolase is tetrameric and produces tagarose-1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. Although structurally similar, the class I aldolases use a different mechanism and are believed to have an independent evolutionary origin.


Pssm-ID: 238255  Cd Length: 340  Bit Score: 450.80  E-value: 6.50e-161
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029   6 TKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTP-GTFKHIA---------------LEEIYALCSAY 69
Cdd:cd00453   1 VQKVFQVAKENNFALPAVNCVGTDSINAVLETAAKVKAPVIVQFSNgGASFIAGkgvksdvpqgaailgAISGAHHVHQM 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029  70 STTYNMPLALHLDHHE--SLDDIRRKVHAG-----------VRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELG 136
Cdd:cd00453  81 AEHYGVPVILHTDHCAkkLLPWIDGLLDAGekhfaatgkplFSSHMIDLSEESLQENIEICSKYLERMSKIGMTLEIELG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029 137 RLGGVEDDMSVDA--ESAFLTDPQEAKRFVELTG----VDSLAVAIGTAHGLYSK-TPKIDFQRLAEIREVV-------- 201
Cdd:cd00453 161 CTGGEEDGVDNSHmdASALYTQPEDVDYAYTELSkispRFTIAASFGNVHGVYKKgNVVLTPTILRDSQEYVskkhnlph 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029 202 -DVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFAGAVKAWFAENP------------------QGNDPRYYMRV 262
Cdd:cd00453 241 nSLNFVFHGGSGSTAQEIKDSVSYGVVKMNIDTDTQWATWEGVLNYYKANEaylqgqlgnpkgedqpnkKYYDPRVWLRA 320

                       330       340
                ....*....|....*....|
gi 16131029 263 GMDAMKEVVRNKINVCGSAN 282
Cdd:cd00453 321 GQTSMIARLEKAFQELNAID 340
Fba COG0191
Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose ...
 2-283 1.08e-146

Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose/tagatose bisphosphate aldolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439961  Cd Length: 283  Bit Score: 412.56  E-value: 1.08e-146
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029   2 SIISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTYNMPLALHL 81
Cdd:COG0191   1 MLVSLKELLDKAKEGGYAVPAFNVNNLETLQAILEAAEELNSPVILQVSEGAAKYAGLEYLAAMVRAAAEEASVPVALHL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029  82 DHHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAESAFLTDPQEAK 161
Cdd:COG0191  81 DHGASFELIKRAIDAGFTSVMIDGSHLPFEENIAITKEVVEYAHAAGVSVEAELGVVGGEEDGVDVDDAEALYTDPEEAA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029 162 RFVELTGVDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFAG 241
Cdd:COG0191 161 EFVEETGVDALAVAIGTVHGVYKGEPKLDFDRLKEIREAVPVPLVLHGGSGVPDEEIREAIKLGVAKINIDTDLRLAFTA 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 16131029 242 AVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANR 283
Cdd:COG0191 241 AVREYLAENPDKYDPRKYLKPAREAMKEVVKEKIRLFGSAGK 282
F_bP_aldolase pfam01116
Fructose-bisphosphate aldolase class-II;
4-283 2.59e-135

Fructose-bisphosphate aldolase class-II;


Pssm-ID: 460071  Cd Length: 276  Bit Score: 383.30  E-value: 2.59e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029     4 ISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIA--LEEIYALCSAYSTTYNMPLALHL 81
Cdd:pfam01116   1 VNLKELLKKAKEGGYAVPAFNVNNLETVQAILEAAEEAKSPVILQVSPGAAAKYAggAEALAALVRAAAEAAGVPVALHL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029    82 DHHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDmsVDAESAFLTDPQEAK 161
Cdd:pfam01116  81 DHGASFELIKEAIEAGFTSVMIDGSHLPFEENIAITKEVVEYAHARGVSVEAELGRIGGEEDG--VVVDEKLYTDPEEAA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029   162 RFVELTGVDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFAG 241
Cdd:pfam01116 159 EFVEATGVDALAVAIGNVHGVYKPGPKLDFDRLKEIQEAVPVPLVLHGGSGVPDEDIRKAIKLGVCKINIDTDLQLAFTA 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 16131029   242 AVKawfaENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANR 283
Cdd:pfam01116 239 AVR----EYPPNKDPRKYLRPAEEAMKEVVKEKIRLFGSAGK 276
 
Name Accession Description Interval E-value
kbaY PRK12738
tagatose-bisphosphate aldolase subunit KbaY;
1-286 0e+00

tagatose-bisphosphate aldolase subunit KbaY;


Pssm-ID: 183711  Cd Length: 286  Bit Score: 635.15  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029    1 MSIISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTYNMPLALH 80
Cdd:PRK12738   1 MSIISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTYNMPLALH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029   81 LDHHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAESAFLTDPQEA 160
Cdd:PRK12738  81 LDHHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAESAFLTDPQEA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029  161 KRFVELTGVDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFA 240
Cdd:PRK12738 161 KRFVELTGVDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFA 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 16131029  241 GAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANRISA 286
Cdd:PRK12738 241 GAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANRISA 286
tag_bisphos_ald TIGR01858
class II aldolase, tagatose bisphosphate family; This model describes tagatose-1, ...
 3-284 0e+00

class II aldolase, tagatose bisphosphate family; This model describes tagatose-1,6-bisphosphate aldolases, and perhaps other closely related class II aldolases. This tetrameric, Zn2+-dependent enzyme is related to the class II fructose bisphosphate aldolase; fructose 1,6-bisphosphate and tagatose 1,6 bisphosphate differ only in chirality at C4.


Pssm-ID: 130917  Cd Length: 282  Bit Score: 541.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029     3 IISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTYNMPLALHLD 82
Cdd:TIGR01858   1 IVSTKYMLQDAQAGGYAVPAFNIHNLETIQAVVETAAEMRSPVILAGTPGTFKHAGTEYIVALCSAASTTYNMPLALHLD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029    83 HHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAESAFLTDPQEAKR 162
Cdd:TIGR01858  81 HHESLDDIRQKVHAGVRSAMIDGSHFPFAQNVKLVKEVVDFCHRQDCSVEAELGRLGGVEDDLSVDEEDALYTDPQEAKE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029   163 FVELTGVDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFAGA 242
Cdd:TIGR01858 161 FVEATGVDSLAVAIGTAHGLYKKTPKLDFDRLAEIREVVDVPLVLHGASDVPDEDVRRTIELGICKVNVATELKIAFSGA 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 16131029   243 VKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANRI 284
Cdd:TIGR01858 241 VKAYFAENPQANDPRYYMRPGKDAMKKVVRNKINVCGSAGRA 282
gatY PRK12737
tagatose-bisphosphate aldolase subunit GatY;
1-284 2.91e-170

tagatose-bisphosphate aldolase subunit GatY;


Pssm-ID: 183710  Cd Length: 284  Bit Score: 472.26  E-value: 2.91e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029    1 MSIISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTYNMPLALH 80
Cdd:PRK12737   1 MYIISTKNMLKKAQAEGYAVPAFNIHNLETLQVVVETAAELRSPVILAGTPGTFSYAGTDYIVAIAEVAARKYNIPLALH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029   81 LDHHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAESAFLTDPQEA 160
Cdd:PRK12737  81 LDHHEDLDDIKKKVRAGIRSVMIDGSHLSFEENIAIVKEVVEFCHRYDASVEAELGRLGGQEDDLVVDEKDAMYTNPDAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029  161 KRFVELTGVDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFA 240
Cdd:PRK12737 161 AEFVERTGIDSLAVAIGTAHGLYKGEPKLDFERLAEIREKVSIPLVLHGASGVPDEDVKKAISLGICKVNVATELKIAFS 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 16131029  241 GAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANRI 284
Cdd:PRK12737 241 DAVKKYFYENPKANDPRKYMTPGKAAMKEVVREKIKVCGSEGKL 284
gatY PRK09195
tagatose-bisphosphate aldolase; Reviewed
 1-284 4.41e-169

tagatose-bisphosphate aldolase; Reviewed


Pssm-ID: 181690  Cd Length: 284  Bit Score: 469.22  E-value: 4.41e-169
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029    1 MSIISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTYNMPLALH 80
Cdd:PRK09195   1 MYLVSTKQMLNNAQRGGYAVPAFNIHNLETMQVVVETAAELHSPVIIAGTPGTFSYAGTEYLLAIVSAAAKQYHHPLALH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029   81 LDHHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAESAFLTDPQEA 160
Cdd:PRK09195  81 LDHHEKFDDIAQKVRSGVRSVMIDGSHLPFAQNISLVKEVVDFCHRFDVSVEAELGRLGGQEDDLQVDEADALYTDPAQA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029  161 KRFVELTGVDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFA 240
Cdd:PRK09195 161 REFVEATGIDSLAVAIGTAHGMYKGEPKLDFDRLENIRQWVNIPLVLHGASGLPTKDIQQTIKLGICKVNVATELKIAFS 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 16131029  241 GAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANRI 284
Cdd:PRK09195 241 QALKNYLTEHPEANDPRHYLQPAKSAMKDVVSKVIADCGCEGKA 284
FTBP_aldolase_II cd00453
Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1, ...
 6-282 6.50e-161

Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to yield fructose-1,6-bisphosphate. TBP-aldolase is tetrameric and produces tagarose-1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. Although structurally similar, the class I aldolases use a different mechanism and are believed to have an independent evolutionary origin.


Pssm-ID: 238255  Cd Length: 340  Bit Score: 450.80  E-value: 6.50e-161
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029   6 TKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTP-GTFKHIA---------------LEEIYALCSAY 69
Cdd:cd00453   1 VQKVFQVAKENNFALPAVNCVGTDSINAVLETAAKVKAPVIVQFSNgGASFIAGkgvksdvpqgaailgAISGAHHVHQM 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029  70 STTYNMPLALHLDHHE--SLDDIRRKVHAG-----------VRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELG 136
Cdd:cd00453  81 AEHYGVPVILHTDHCAkkLLPWIDGLLDAGekhfaatgkplFSSHMIDLSEESLQENIEICSKYLERMSKIGMTLEIELG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029 137 RLGGVEDDMSVDA--ESAFLTDPQEAKRFVELTG----VDSLAVAIGTAHGLYSK-TPKIDFQRLAEIREVV-------- 201
Cdd:cd00453 161 CTGGEEDGVDNSHmdASALYTQPEDVDYAYTELSkispRFTIAASFGNVHGVYKKgNVVLTPTILRDSQEYVskkhnlph 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029 202 -DVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFAGAVKAWFAENP------------------QGNDPRYYMRV 262
Cdd:cd00453 241 nSLNFVFHGGSGSTAQEIKDSVSYGVVKMNIDTDTQWATWEGVLNYYKANEaylqgqlgnpkgedqpnkKYYDPRVWLRA 320

                       330       340
                ....*....|....*....|
gi 16131029 263 GMDAMKEVVRNKINVCGSAN 282
Cdd:cd00453 321 GQTSMIARLEKAFQELNAID 340
cbbA TIGR00167
ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model ...
 1-284 8.74e-155

ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model include fructose-bisphosphate and tagatose-bisphosphate aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 272938  Cd Length: 288  Bit Score: 433.28  E-value: 8.74e-155
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029     1 MSIISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIA-LEEIYALCSAYSTTY--NMPL 77
Cdd:TIGR00167   1 MMLVDVKELLQDAKEEGYAIPAFNINNLETINAVLEAAAEEKSPVIIQFSNGAAKYIAgLGAISAMVKAMSEAYpyGVPV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029    78 ALHLDHHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAESAFLTDP 157
Cdd:TIGR00167  81 ALHLDHGASEEDCAQAVKAGFSSVMIDGSHEPFEENIELTKKVVERAHKMGVSVEAELGTLGGEEDGVSVADESALYTDP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029   158 QEAKRFVELTGVDSLAVAIGTAHGLYSKTPK-IDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELK 236
Cdd:TIGR00167 161 EEAKEFVKLTGVDSLAAAIGNVHGVYKGEPKgLDFERLEEIQKYVNLPLVLHGGSGIPDEEIKKAISLGVVKVNIDTELQ 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 16131029   237 IAFAGAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANRI 284
Cdd:TIGR00167 241 IAFAAAVRNYYAENKDYYDPRVWLRPGEKAMKEVVLEKIKLFGSANKA 288
Fba COG0191
Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose ...
 2-283 1.08e-146

Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose/tagatose bisphosphate aldolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439961  Cd Length: 283  Bit Score: 412.56  E-value: 1.08e-146
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029   2 SIISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTYNMPLALHL 81
Cdd:COG0191   1 MLVSLKELLDKAKEGGYAVPAFNVNNLETLQAILEAAEELNSPVILQVSEGAAKYAGLEYLAAMVRAAAEEASVPVALHL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029  82 DHHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAESAFLTDPQEAK 161
Cdd:COG0191  81 DHGASFELIKRAIDAGFTSVMIDGSHLPFEENIAITKEVVEYAHAAGVSVEAELGVVGGEEDGVDVDDAEALYTDPEEAA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029 162 RFVELTGVDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFAG 241
Cdd:COG0191 161 EFVEETGVDALAVAIGTVHGVYKGEPKLDFDRLKEIREAVPVPLVLHGGSGVPDEEIREAIKLGVAKINIDTDLRLAFTA 240

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 16131029 242 AVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANR 283
Cdd:COG0191 241 AVREYLAENPDKYDPRKYLKPAREAMKEVVKEKIRLFGSAGK 282
TBP_aldolase_IIB cd00947
Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase ...
 6-282 8.63e-145

Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238477  Cd Length: 276  Bit Score: 407.30  E-value: 8.63e-145
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029   6 TKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTYNMPLALHLDHHE 85
Cdd:cd00947   1 TKELLKKAREGGYAVGAFNINNLETLKAILEAAEETRSPVILQISEGAIKYAGLELLVAMVKAAAERASVPVALHLDHGS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029  86 SLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAesAFLTDPQEAKRFVE 165
Cdd:cd00947  81 SFELIKRAIRAGFSSVMIDGSHLPFEENVAKTKEVVELAHAYGVSVEAELGRIGGEEDGVVGDE--GLLTDPEEAEEFVE 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029 166 LTGVDSLAVAIGTAHGLY-SKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFAGAVK 244
Cdd:cd00947 159 ETGVDALAVAIGTSHGAYkGGEPKLDFDRLKEIAERVNVPLVLHGGSGIPDEQIRKAIKLGVCKININTDLRLAFTAALR 238

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 16131029 245 AWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSAN 282
Cdd:cd00947 239 EYLAENPKEFDPRKYLAPAIEAVKEVVKHKMELFGSAG 276
F_bP_aldolase pfam01116
Fructose-bisphosphate aldolase class-II;
4-283 2.59e-135

Fructose-bisphosphate aldolase class-II;


Pssm-ID: 460071  Cd Length: 276  Bit Score: 383.30  E-value: 2.59e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029     4 ISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIA--LEEIYALCSAYSTTYNMPLALHL 81
Cdd:pfam01116   1 VNLKELLKKAKEGGYAVPAFNVNNLETVQAILEAAEEAKSPVILQVSPGAAAKYAggAEALAALVRAAAEAAGVPVALHL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029    82 DHHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDmsVDAESAFLTDPQEAK 161
Cdd:pfam01116  81 DHGASFELIKEAIEAGFTSVMIDGSHLPFEENIAITKEVVEYAHARGVSVEAELGRIGGEEDG--VVVDEKLYTDPEEAA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029   162 RFVELTGVDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFAG 241
Cdd:pfam01116 159 EFVEATGVDALAVAIGNVHGVYKPGPKLDFDRLKEIQEAVPVPLVLHGGSGVPDEDIRKAIKLGVCKINIDTDLQLAFTA 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 16131029   242 AVKawfaENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANR 283
Cdd:pfam01116 239 AVR----EYPPNKDPRKYLRPAEEAMKEVVKEKIRLFGSAGK 276
PRK12857 PRK12857
class II fructose-1,6-bisphosphate aldolase;
1-284 3.93e-112

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 237235  Cd Length: 284  Bit Score: 325.14  E-value: 3.93e-112
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029    1 MSIISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTYNMPLALH 80
Cdd:PRK12857   1 MMLVTVAELLKKAEKGGYAVGAFNCNNMEIVQAIVAAAEAEKSPVIIQASQGAIKYAGIEYISAMVRTAAEKASVPVALH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029   81 LDHHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAESAFLTDPQEA 160
Cdd:PRK12857  81 LDHGTDFEQVMKCIRNGFTSVMIDGSKLPLEENIALTKKVVEIAHAVGVSVEAELGKIGGTEDDITVDEREAAMTDPEEA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029  161 KRFVELTGVDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFA 240
Cdd:PRK12857 161 RRFVEETGVDALAIAIGTAHGPYKGEPKLDFDRLAKIKELVNIPIVLHGSSGVPDEAIRKAISLGVRKVNIDTNIREAFV 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 16131029  241 GAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANRI 284
Cdd:PRK12857 241 ARLREVLEKNPDEIDPRKILGPAREAAKEVIREKIRLFGSAGKA 284
fruc_bis_ald_ TIGR01859
fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; ...
 3-284 1.39e-110

fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; This model represents of one of several subtypes of the class II fructose-1,6-bisphosphate aldolase, an enzyme of glycolysis. The subtypes are split into several models to allow separation of a family of tagatose bisphosphate aldolases. This form is found in Gram-positive bacteria, a variety of Gram-negative, and in amitochondriate protists. The class II enzymes share homology with tagatose bisphosphate aldolase but not with class I aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 130918  Cd Length: 282  Bit Score: 321.23  E-value: 1.39e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029     3 IISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHI-ALEEIYALCSAYSTTYN-MPLALH 80
Cdd:TIGR01859   1 LVNGKEILQKAKKEGYAVGAFNFNNLEWTQAILEAAEEENSPVIIQVSEGAIKYMgGYKMAVAMVKTLIERMSiVPVALH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029    81 LDHHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDmsVDAESAFLTDPQEA 160
Cdd:TIGR01859  81 LDHGSSYESCIKAIKAGFSSVMIDGSHLPFEENLALTKKVVEIAHAKGVSVEAELGTLGGIEDG--VDEKEAELADPDEA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029   161 KRFVELTGVDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFA 240
Cdd:TIGR01859 159 EQFVKETGVDYLAAAIGTSHGKYKGEPGLDFERLKEIKELTNIPLVLHGASGIPEEQIKKAIKLGIAKINIDTDCRIAFT 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 16131029   241 GAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANRI 284
Cdd:TIGR01859 239 AAIRKVLTEKKDEYDPRKILGPAREAIKETVKEKMRLFGSAGKA 282
PRK08185 PRK08185
hypothetical protein; Provisional
 7-285 7.28e-86

hypothetical protein; Provisional


Pssm-ID: 181275  Cd Length: 283  Bit Score: 258.12  E-value: 7.28e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029    7 KYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIAlEEIYALCSAYSTTYNMPLALHLDHHES 86
Cdd:PRK08185   2 KELLKVAKEHQFAVGAFNVADSCFLRAVVEEAEANNAPAIIAIHPNELDFLG-DNFFAYVRERAKRSPVPFVIHLDHGAT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029   87 LDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAESAFLTDPQEAKRFVEL 166
Cdd:PRK08185  81 IEDVMRAIRCGFTSVMIDGSLLPYEENVALTKEVVELAHKVGVSVEGELGTIGNTGTSIEGGVSEIIYTDPEQAEDFVSR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029  167 TGVDSLAVAIGTAHGLYSK--TPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFAGAVK 244
Cdd:PRK08185 161 TGVDTLAVAIGTAHGIYPKdkKPELQMDLLKEINERVDIPLVLHGGSANPDAEIAESVQLGVGKINISSDMKYAFFKKVR 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 16131029  245 AWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANRIS 285
Cdd:PRK08185 241 EILSDNPSLYEPNQIYPSAIEAAKEVVRHKMDLFNSTGKAD 281
PRK05835 PRK05835
class II fructose-1,6-bisphosphate aldolase;
3-284 2.04e-85

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 180280 [Multi-domain]  Cd Length: 307  Bit Score: 257.98  E-value: 2.04e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029    3 IISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTY-NMPLALHL 81
Cdd:PRK05835   2 LVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERYpHIPVALHL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029   82 DHHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAESAFLTDPQEAK 161
Cdd:PRK05835  82 DHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDEKDAVLVNPKEAE 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029  162 RFVELTGVDSLAVAIGTAHGL--YSKTPKIDFQRLAEIREVVDVPLVLHGASDVPD---------------------EFV 218
Cdd:PRK05835 162 QFVKESQVDYLAPAIGTSHGAfkFKGEPKLDFERLQEVKRLTNIPLVLHGASAIPDdvrksyldaggdlkgskgvpfEFL 241

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 16131029  219 RRTIELGVTKVNVATELKIAFAGAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANRI 284
Cdd:PRK05835 242 QESVKGGINKVNTDTDLRIAFIAEVRKVANEDKSQFDLRKFFSPAQLALKNVVKERMKLLGSANKI 307
PRK08610 PRK08610
fructose-bisphosphate aldolase; Reviewed
 1-283 7.47e-83

fructose-bisphosphate aldolase; Reviewed


Pssm-ID: 181501  Cd Length: 286  Bit Score: 250.67  E-value: 7.47e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029    1 MSIISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIA-LEEIYALCSAYSTTYNM--PL 77
Cdd:PRK08610   1 MPLVSMKEMLIDAKENGYAVGQYNLNNLEFTQAILEASQEENAPVILGVSEGAARYMSgFYTVVKMVEGLMHDLNItiPV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029   78 ALHLDHHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDmsVDAESAFLTDP 157
Cdd:PRK08610  81 AIHLDHGSSFEKCKEAIDAGFTSVMIDASHSPFEENVATTKKVVEYAHEKGVSVEAELGTVGGQEDD--VVADGIIYADP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029  158 QEAKRFVELTGVDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKI 237
Cdd:PRK08610 159 KECQELVEKTGIDALAPALGSVHGPYKGEPKLGFKEMEEIGLSTGLPLVLHGGTGIPTKDIQKAIPFGTAKINVNTENQI 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 16131029  238 AFAGAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANR 283
Cdd:PRK08610 239 ASAKAVRDVLNNDKEVYDPRKYLGPAREAIKETVKGKIKEFGTSNR 284
PRK07709 PRK07709
fructose-bisphosphate aldolase; Provisional
 1-283 6.83e-79

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 169068  Cd Length: 285  Bit Score: 240.73  E-value: 6.83e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029    1 MSIISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIA-LEEIYALCSAYSTTYNM--PL 77
Cdd:PRK07709   1 MPLVSMKEMLNKALEGKYAVGQFNMNNLEWTQAILAAAEEEKSPVILGVSEGAARHMTgFKTVVAMVKALIEEMNItvPV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029   78 ALHLDHHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDmsVDAESAFLTDP 157
Cdd:PRK07709  81 AIHLDHGSSFEKCKEAIDAGFTSVMIDASHHPFEENVETTKKVVEYAHARNVSVEAELGTVGGQEDD--VIAEGVIYADP 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029  158 QEAKRFVELTGVDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKI 237
Cdd:PRK07709 159 AECKHLVEATGIDCLAPALGSVHGPYKGEPNLGFAEMEQVRDFTGVPLVLHGGTGIPTADIEKAISLGTSKINVNTENQI 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 16131029  238 AFAGAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANR 283
Cdd:PRK07709 239 EFTKAVREVLNKDQEVYDPRKFIGPGRDAIKATVIGKIREFGSNGK 284
gatY PRK07998
class II aldolase;
1-277 7.13e-79

class II aldolase;


Pssm-ID: 181192  Cd Length: 283  Bit Score: 240.43  E-value: 7.13e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029    1 MSIISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTYNMPLALH 80
Cdd:PRK07998   1 MPLVNGRILLDRIQEKHVLAGAFNTTNLETTISILNAIERSGLPNFIQIAPTNAQLSGYDYIYEIVKRHADKMDVPVSLH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029   81 LDHHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAESAflTDPQEA 160
Cdd:PRK07998  81 LDHGKTFEDVKQAVRAGFTSVMIDGAALPFEENIAFTKEAVDFAKSYGVPVEAELGAILGKEDDHVSEADCK--TEPEKV 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029  161 KRFVELTGVDSLAVAIGTAHGLySKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFA 240
Cdd:PRK07998 159 KDFVERTGCDMLAVSIGNVHGL-EDIPRIDIPLLKRIAEVSPVPLVIHGGSGIPPEILRSFVNYKVAKVNIASDLRKAFI 237

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 16131029  241 GAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINV 277
Cdd:PRK07998 238 TTVGKAYVNNHNEANLARVMAKAKQAVEEDVYSKIKM 274
PRK07084 PRK07084
class II fructose-1,6-bisphosphate aldolase;
1-284 1.15e-74

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 180829  Cd Length: 321  Bit Score: 231.15  E-value: 1.15e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029    1 MSIISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHiALEEIY------ALCSAYSTTYN 74
Cdd:PRK07084   7 LGLVNTREMFAKAVKGGYAIPAYNFNNMEQLQAIIQACVETKSPVILQVSKGARKY-ANATLLrymaqgAVEYAKELGCP 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029   75 MPLALHLDHHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSvdAESAFL 154
Cdd:PRK07084  86 IPIVLHLDHGDSFELCKDCIDSGFSSVMIDGSHLPYEENVALTKKVVEYAHQFDVTVEGELGVLAGVEDEVS--AEHHTY 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029  155 TDPQEAKRFVELTGVDSLAVAIGTAHGLYSKTP-----KIDFQRLAEI-REVVDVPLVLHGASDVPDEFV---------- 218
Cdd:PRK07084 164 TQPEEVEDFVKKTGVDSLAISIGTSHGAYKFKPgqcppPLRFDILEEIeKRIPGFPIVLHGSSSVPQEYVktineyggkl 243

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 16131029  219 -----------RRTIELGVTKVNVATELKIAFAGAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNK-INVCGSANRI 284
Cdd:PRK07084 244 kdaigipeeqlRKAAKSAVCKINIDSDGRLAMTAAIRKVFDEKPEEFDPRKYLGPARDELKKLYKHKiINVLGSNGKA 321
PRK06806 PRK06806
class II aldolase;
1-283 6.42e-69

class II aldolase;


Pssm-ID: 180705  Cd Length: 281  Bit Score: 215.00  E-value: 6.42e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029    1 MSIISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTYNMPLALH 80
Cdd:PRK06806   1 MPLVQMKELLKKANQENYGVGAFSVANMEMVMGAIKAAEELNSPIILQIAEVRLNHSPLHLIGPLMVAAAKQAKVPVAVH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029   81 LDHHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDmSVDaESAFLTDPQEA 160
Cdd:PRK06806  81 FDHGMTFEKIKEALEIGFTSVMFDGSHLPLEENIQKTKEIVELAKQYGATVEAEIGRVGGSEDG-SED-IEMLLTSTTEA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029  161 KRFVELTGVDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFA 240
Cdd:PRK06806 159 KRFAEETDVDALAVAIGNAHGMYNGDPNLRFDRLQEINDVVHIPLVLHGGSGISPEDFKKCIQHGIRKINVATATFNSVI 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 16131029  241 GAVKAWFAENPQgNDPRYYMRVGMDAMKEVVRNKINVCGSANR 283
Cdd:PRK06806 239 TAVNNLVLNTPY-SDYFTYHQDVIKAAYENVKKHMQIFGSENK 280
PRK06801 PRK06801
ketose 1,6-bisphosphate aldolase;
1-284 1.69e-68

ketose 1,6-bisphosphate aldolase;


Pssm-ID: 180701  Cd Length: 286  Bit Score: 214.23  E-value: 1.69e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029    1 MSIISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTYNMPLALH 80
Cdd:PRK06801   1 MALISLANGLAHARKHGYALGAFNVLDSHFLRALFAAAKQERSPFIINIAEVHFKYISLESLVEAVKFEAARHDIPVVLN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029   81 LDHHESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDD-MSVDAESAFLTDPQE 159
Cdd:PRK06801  81 LDHGLHFEAVVRALRLGFSSVMFDGSTLEYEENVRQTREVVKMCHAVGVSVEAELGAVGGDEGGaLYGEADSAKFTDPQL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029  160 AKRFVELTGVDSLAVAIGTAHGLYSKTPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAF 239
Cdd:PRK06801 161 ARDFVDRTGIDALAVAIGNAHGKYKGEPKLDFARLAAIHQQTGLPLVLHGGSGISDADFRRAIELGIHKINFYTGMSQAA 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 16131029  240 AGAVKAWFAENPQGNDPRYYMRVGMD-AMKEVVRNKINVCGSANRI 284
Cdd:PRK06801 241 LAAVEQRMTHRHAIYDEFAELLLGIEeAISDTVAQQMRIFGSAGQA 286
PRK09196 PRK09196
fructose-bisphosphate aldolase class II;
1-281 5.30e-68

fructose-bisphosphate aldolase class II;


Pssm-ID: 181691  Cd Length: 347  Bit Score: 214.82  E-value: 5.30e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029    1 MSIISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTY-NMPLAL 79
Cdd:PRK09196   1 MALISLRQLLDHAAEHGYGVPAFNVNNLEQVQAIMEAADETDSPVILQASAGARKYAGEPFLRHLILAAVEEYpHIPVVM 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029   80 HLDHHESLDDIRRKVHAGVRSAMIDGSHFP-------FAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSvDAE-- 150
Cdd:PRK09196  81 HQDHGNSPATCQRAIQLGFTSVMMDGSLKAdgktpasYEYNVDVTRKVVEMAHACGVSVEGELGCLGSLETGMG-GEEdg 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029  151 ---------SAFLTDPQEAKRFVELTGVDSLAVAIGTAHGLYSKTPKID-----FQRLAEI-REVVDVPLVLHGASDVPD 215
Cdd:PRK09196 160 hgaegklshDQLLTDPEEAADFVKKTQVDALAIAIGTSHGAYKFTRKPTgdvlaIDRIKEIhARLPNTHLVMHGSSSVPQ 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029  216 EF---------------------VRRTIELGVTKVNVATELKIAFAGAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNK 274
Cdd:PRK09196 240 ELldiineyggdmpetygvpveeIQEGIKHGVRKVNIDTDLRLAMTGAIRRFLAENPSEFDPRKYLKPAMEAMKKICKAR 319


                 ....*..
gi 16131029  275 INVCGSA 281
Cdd:PRK09196 320 YEAFGTA 326
PLN02858 PLN02858
fructose-bisphosphate aldolase
 5-283 1.47e-63

fructose-bisphosphate aldolase


Pssm-ID: 215463 [Multi-domain]  Cd Length: 1378  Bit Score: 216.26  E-value: 1.47e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029     5 STKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTYnMPLALHLDHH 84
Cdd:PLN02858 1101 STKELLLNAEKGGYAVGAFNVYNLEGIEAVVAAAEAEKSPAILQVHPGALKQGGIPLVSCCIAAAEQAS-VPITVHFDHG 1179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029    85 ESLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAESAFLTDPQEAKRFV 164
Cdd:PLN02858 1180 TSKHELLEALELGFDSVMVDGSHLSFTENISYTKSISSLAHSKGLMVEAELGRLSGTEDGLTVEEYEAKLTDVDQAKEFI 1259

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029   165 ELTGVDSLAVAIGTAHGLYSKT-PKIDFQRLAEIREVV---DVPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFA 240
Cdd:PLN02858 1260 DETGIDALAVCIGNVHGKYPASgPNLRLDLLKELRALSskkGVLLVLHGASGLPESLIKECIENGVRKFNVNTEVRTAYM 1339

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 16131029   241 GAVKAwfaenPQGNDPRYYMRVGMDAMKEVVRNKINVCGSANR 283
Cdd:PLN02858 1340 EALSS-----PKKTDLIDVMSAAKEAMKAVVAEKLRLFGSAGK 1377
PRK13399 PRK13399
fructose-bisphosphate aldolase class II;
1-285 2.00e-61

fructose-bisphosphate aldolase class II;


Pssm-ID: 184029  Cd Length: 347  Bit Score: 198.08  E-value: 2.00e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029    1 MSIISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTY-NMPLAL 79
Cdd:PRK13399   1 MALITLRQLLDHAAENGYGVPAFNVNNMEQILAIMEAAEATDSPVILQASRGARKYAGDAMLRHMVLAAAEMYpDIPICL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029   80 HLDHHESLDDIRRKVHAGVRSAMIDGSHFP-------FAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMS-----V 147
Cdd:PRK13399  81 HQDHGNSPATCQSAIRSGFTSVMMDGSLLAdgktpasYDYNVDVTRRVTEMAHAVGVSVEGELGCLGSLETGEAgeedgV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029  148 DAE-----SAFLTDPQEAKRFVELTGVDSLAVAIGTAHGLYSKTPKID-----FQRLAEI-REVVDVPLVLHGASDVPDE 216
Cdd:PRK13399 161 GAEgklshDQMLTDPDQAVDFVQRTGVDALAIAIGTSHGAYKFTRKPDgdilaIDRIEEIhARLPNTHLVMHGSSSVPQE 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029  217 F---------------------VRRTIELGVTKVNVATELKIAFAGAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKI 275
Cdd:PRK13399 241 LqeiinayggkmketygvpveeIQRGIKHGVRKVNIDTDIRLAMTGAIRKVLAEHPSEFDPRKALKPAMKAMTALCKQRF 320

                        330
                 ....*....|
gi 16131029  276 NVCGSANRIS 285
Cdd:PRK13399 321 EAFGTAGQAS 330
PRK07315 PRK07315
fructose-bisphosphate aldolase; Provisional
 1-283 3.35e-61

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 180926  Cd Length: 293  Bit Score: 195.49  E-value: 3.35e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029    1 MSIISTKYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALeeiYALCSAY------STTYN 74
Cdd:PRK07315   1 MAIVSAEKFVQAARDNGYAVGGFNTNNLEWTQAILRAAEAKKAPVLIQTSMGAAKYMGG---YKVCKNLienlveSMGIT 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029   75 MPLALHLDHHEsLDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVEDDMSVDAEsafL 154
Cdd:PRK07315  78 VPVAIHLDHGH-YEDALECIEVGYTSIMFDGSHLPVEENLKLAKEVVEKAHAKGISVEAEVGTIGGEEDGIIGKGE---L 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029  155 TDPQEAKRFVElTGVDSLAVAIGTAHGLYSKTPK-IDFQRLAEIREVV-DVPLVLHGASDVPDEFVRRTIELGVTKVNVA 232
Cdd:PRK07315 154 APIEDAKAMVE-TGIDFLAAGIGNIHGPYPENWEgLDLDHLEKLTEAVpGFPIVLHGGSGIPDDQIQEAIKLGVAKVNVN 232

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16131029  233 TELKIAFAGAVKAwFAENPQGN----------DPRYYMRVGMDAMKEVVRNKINVCGSANR 283
Cdd:PRK07315 233 TECQIAFANATRK-FARDYEANeaeydkkklfDPRKFLAPGVKAIQASVEERIDVFGSANK 292
FBP_aldolase_IIA cd00946
Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the ...
 9-283 4.96e-26

Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is homodimeric and used in gluconeogenesis and glycolysis. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238476  Cd Length: 345  Bit Score: 104.76  E-value: 4.96e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029   9 LLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIY----------ALCSAY-----STTY 73
Cdd:cd00946   7 LFDYAKENGFAIPAVNCTSSSTINAVLEAARDAKSPIIIQFSNGGAAFYAGKGLKnekqkasiagAIAAAHhvrsmAEHY 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029  74 NMPLALHLDHHE-----------SLDDIRRKVHaGV---RSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLG 139
Cdd:cd00946  87 GVPVVLHTDHCAkkllpwfdgllEADEEYFKQH-GEplfSSHMLDLSEEPLEENIEICKKYLERMAKINMWLEMEIGITG 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029 140 GVED--DMSVDAESAFLTDPQEA----KRFVELTGVDSLAVAIGTAHGLYSK-----TPKIDFQRLAEIREVV----DVP 204
Cdd:cd00946 166 GEEDgvDNSGVDNAELYTQPEDVwyvyEALSKISPNFSIAAAFGNVHGVYKPgnvklQPEILGEHQDYVREKLgladDKP 245

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029 205 L--VLHGASDVPDEFVRRTIELGVTKVNVATELKIAFAGAVKAWFAEN------PQGN------------DPRYYMRVGM 264
Cdd:cd00946 246 LyfVFHGGSGSTKEEIREAISYGVVKMNIDTDTQWAYWEGVRNYYLKNedylqgQIGNpegpdkpnkkyyDPRVWLREGE 325

                       330
                ....*....|....*....
gi 16131029 265 DAMKEVVRNKINVCGSANR 283
Cdd:cd00946 326 KSMVARVKKAFEDLNSVNK 344
PRK09197 PRK09197
fructose-bisphosphate aldolase; Provisional
 9-283 6.54e-26

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 236406  Cd Length: 350  Bit Score: 104.49  E-value: 6.54e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029    9 LLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVI----------LAGTpgTFKH----------IALEEIYALCSA 68
Cdd:PRK09197  12 MFDRAKENGFALPAVNVVGTDSINAVLEGAAEAKSPVIiqfsnggaafIAGK--GVKDdgqgaavlgaIAGAKHVHEVAE 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029   69 YsttYNMPLALHLDH--HESLDDIR-------RKVHAGVR----SAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAEL 135
Cdd:PRK09197  90 H---YGVPVILHTDHcaKKLLPWIDglldageKHFAAGGKplfsSHMIDLSEEPLEENIEICSKYLERMAKAGMTLEIEL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029  136 GRLGGVED--DMSVDAESAFLTDPQEAKRFVELTGVDS----LAVAIGTAHGLYSK-----TPKIdfqrLAEIREVVD-- 202
Cdd:PRK09197 167 GVTGGEEDgvDNSHEDNSKLYTQPEDVLYAYEALGKISgrftIAASFGNVHGVYKPgnvklRPEI----LKDSQEYVSkk 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029  203 -------VPLVLHGASDVPDEFVRRTIELGVTKVNVATELKIAFAGAVKAWFAE----------NPQGN--------DPR 257
Cdd:PRK09197 243 fglpakpFDFVFHGGSGSTLEEIREAVSYGVVKMNIDTDTQWAFWRGVLDYYFKnydylqgqvgNPEGEdkpnkkyyDPR 322

                        330       340
                 ....*....|....*....|....*.
gi 16131029  258 YYMRVGMDAMKEVVRNKINVCGSANR 283
Cdd:PRK09197 323 VWLRAAEASMAARLEEAFEDLNSIGV 348
metallo-dependent_hydrolases cd01292
Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a ...
 87-278 4.44e-03

Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a conserved metal binding site, involving four histidines and one aspartic acid residue. In the common reaction mechanism, the metal ion (or ions) deprotonate a water molecule for a nucleophilic attack on the substrate. The family includes urease alpha, adenosine deaminase, phosphotriesterase dihydroorotases, allantoinases, hydantoinases, AMP-, adenine and cytosine deaminases, imidazolonepropionase, aryldialkylphosphatase, chlorohydrolases, formylmethanofuran dehydrogenases and others.


Pssm-ID: 238617 [Multi-domain]  Cd Length: 275  Bit Score: 38.08  E-value: 4.44e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029  87 LDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSveaELGRLGGVEDDMSVDAESAFLTDPQEAKRFVEL 166
Cdd:cd01292  38 LRALEALLAGGVTTVVDMGSTPPPTTTKAAIEAVAEAARASAGI---RVVLGLGIPGVPAAVDEDAEALLLELLRRGLEL 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131029 167 tgvdsLAVAIGtAHGLYSKTPKID--FQRLAEIREVVDVPLVLH-GASDVPDEFVRRTIELGVTKVNV------ATELKI 237
Cdd:cd01292 115 -----GAVGLK-LAGPYTATGLSDesLRRVLEEARKLGLPVVIHaGELPDPTRALEDLVALLRLGGRVvighvsHLDPEL 188

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 16131029 238 AF-AGAVKAWFAENPQGNDPRYYMRVGMDAMKEVVRNKINVC 278
Cdd:cd01292 189 LElLKEAGVSLEVCPLSNYLLGRDGEGAEALRRLLELGIRVT 230
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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