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Conserved domains on  [gi|16131122|ref|NP_417699|]
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cell division protein ZapE [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

AFG1/ZapE family ATPase( domain architecture ID 11445240)

AFG1/ZapE family ATPase similar to cell division protein ZapE, that interacts with FtsZ and modulates the Z-ring dynamics

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ZapE COG1485
Cell division protein ZapE (Z ring-associated ATPase), AFG1 superfamily [Cell cycle control, ...
2-374 0e+00

Cell division protein ZapE (Z ring-associated ATPase), AFG1 superfamily [Cell cycle control, cell division, chromosome partitioning];


:

Pssm-ID: 441094  Cd Length: 365  Bit Score: 624.81  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131122   2 QSVTPTSQYLKALNEGSHQPDDVQKEAVSRLEIIYQELINstPPAPRTSGLmarvGKLWGKREdtKHTPVRGLYMWGGVG 81
Cdd:COG1485   1 MMMSPLERYQALLAAGGLQPDPAQEAAVARLDRLYDELLA--YRPRKSGLL----GRLFGRKR--KPEPPKGLYLWGGVG 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131122  82 RGKTWLMDLFYQSLPGERKQRLHFHRFMLRVHEELTALQGQTDPLEIIADRFKAETDVLCFDEFFVSDITDAMLLGGLMK 161
Cdd:COG1485  73 RGKTMLMDLFFESLPVERKRRVHFHRFMQEVHARLHALRGQADPLPPVADRIAAEARLLCFDEFHVTDIADAMILGRLFE 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131122 162 ALFARGITLVATSNIPPDELYRNGLQRARFLPAIDAIKQHCDVMNVDAGVDYRLRTLTQAHLWLSPLHDETRAQMDKLWL 241
Cdd:COG1485 153 ALFARGVVLVATSNIPPDDLYKNGLQRARFLPFIALIKQHLDVLNLDSGTDYRLRRLEGAPVYHTPLDAEADAALDAAFA 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131122 242 ALAGGKRENSPTLEINHRPLATMGVENQTLAVSFTTLCVDARSQHDYIALSRLFHTVMLFDVPVMTRLMESEARRFIALV 321
Cdd:COG1485 233 RLTGGAPEEPETLEVNGREIPVPRAAGGVAWFDFADLCGGPRGQADYLELARRFHTVILSDVPVMGPDNRNEARRFITLI 312
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|...
gi 16131122 322 DEFYERHVKLVVSAEVPLYEIYQGDRLKFEFQRCLSRLQEMQSEEYLKREHLA 374
Cdd:COG1485 313 DELYDRRVKLIASAAAPPEELYTGGRGAFEFERTASRLIEMQSEEYLALPHRP 365
 
Name Accession Description Interval E-value
ZapE COG1485
Cell division protein ZapE (Z ring-associated ATPase), AFG1 superfamily [Cell cycle control, ...
2-374 0e+00

Cell division protein ZapE (Z ring-associated ATPase), AFG1 superfamily [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441094  Cd Length: 365  Bit Score: 624.81  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131122   2 QSVTPTSQYLKALNEGSHQPDDVQKEAVSRLEIIYQELINstPPAPRTSGLmarvGKLWGKREdtKHTPVRGLYMWGGVG 81
Cdd:COG1485   1 MMMSPLERYQALLAAGGLQPDPAQEAAVARLDRLYDELLA--YRPRKSGLL----GRLFGRKR--KPEPPKGLYLWGGVG 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131122  82 RGKTWLMDLFYQSLPGERKQRLHFHRFMLRVHEELTALQGQTDPLEIIADRFKAETDVLCFDEFFVSDITDAMLLGGLMK 161
Cdd:COG1485  73 RGKTMLMDLFFESLPVERKRRVHFHRFMQEVHARLHALRGQADPLPPVADRIAAEARLLCFDEFHVTDIADAMILGRLFE 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131122 162 ALFARGITLVATSNIPPDELYRNGLQRARFLPAIDAIKQHCDVMNVDAGVDYRLRTLTQAHLWLSPLHDETRAQMDKLWL 241
Cdd:COG1485 153 ALFARGVVLVATSNIPPDDLYKNGLQRARFLPFIALIKQHLDVLNLDSGTDYRLRRLEGAPVYHTPLDAEADAALDAAFA 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131122 242 ALAGGKRENSPTLEINHRPLATMGVENQTLAVSFTTLCVDARSQHDYIALSRLFHTVMLFDVPVMTRLMESEARRFIALV 321
Cdd:COG1485 233 RLTGGAPEEPETLEVNGREIPVPRAAGGVAWFDFADLCGGPRGQADYLELARRFHTVILSDVPVMGPDNRNEARRFITLI 312
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|...
gi 16131122 322 DEFYERHVKLVVSAEVPLYEIYQGDRLKFEFQRCLSRLQEMQSEEYLKREHLA 374
Cdd:COG1485 313 DELYDRRVKLIASAAAPPEELYTGGRGAFEFERTASRLIEMQSEEYLALPHRP 365
AFG1_ATPase pfam03969
AFG1-like ATPase; This P-loop motif-containing family of proteins includes AFG1, LACE1 and ...
4-371 0e+00

AFG1-like ATPase; This P-loop motif-containing family of proteins includes AFG1, LACE1 and ZapE. ATPase family gene 1 (AFG1) is a 377 amino acid yeast protein with an ATPase motif typical of the family. LACE1, the mammalian homolog of AFG1, is a mitochondrial integral membrane protein that is essential for maintenance of fused mitochondrial reticulum and lamellar cristae morphology. It has also been demonstrated that LACE1 mediates degradation of nuclear-encoded complex IV subunits COX4 (cytochrome c oxidase 4), COX5A and COX6A, and is required for normal activity of complexes III and IV of the respiratory chain. ZapE is a cell division protein found in Gram-negative bacteria. The bacterial cell division process relies on the assembly, positioning, and constriction of FtsZ ring (the so-called Z-ring), a ring-like network that marks the future site of the septum of bacterial cell division. ZapE is a Z-ring associated protein required for cell division under low-oxygen conditions. It is an ATPase that appears at the constricting Z-ring late in cell division. It reduces the stability of FtsZ polymers in the presence of ATP in vitro.


Pssm-ID: 397872  Cd Length: 361  Bit Score: 590.24  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131122     4 VTPTSQYLKALNEGSHQPDDVQKEAVSRLEIIYQELINSTPPAPRtsglmARVGKLWGKREDtkHTPVRGLYMWGGVGRG 83
Cdd:pfam03969   1 TTPPVRYIADLQRPDFFPDVAQANAVPHLDRLYQDLAAQDFPRPA-----RAGGKLWGRKPS--VQPPRGLYLWGGVGRG 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131122    84 KTWLMDLFYQSLPGERKQRLHFHRFMLRVHEELTALQGQTDPLEIIADRFKAETDVLCFDEFFVSDITDAMLLGGLMKAL 163
Cdd:pfam03969  74 KTWLMDLFFESLPGEKKRRTHFHRFMFRVHDELTTLQGGVDPLAIIADRLAGEARLLCFDEFFVSDIGDAMLLGRLFEAL 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131122   164 FARGITLVATSNIPPDELYRNGLQRARFLPAIDAIKQHCDVMNVDAGVDYRLRTLTQAHLWLSPLHDETRAQMDKLWLAL 243
Cdd:pfam03969 154 FARGVTLVATSNIAPEQLYKNGLQRARFLPAIDLLKSHCEVVNVDGGVDYRLRTLRQAELWLYPLDGYCWAAMDRLWDAL 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131122   244 AGGKRENSPTLEINHRPLATMGVENQTLAVSFTTLCVDARSQHDYIALSRLFHTVMLFDVPVMTRLMESEARRFIALVDE 323
Cdd:pfam03969 234 GLGEPEPLSTLEVNARALRARAVGGDLVWFSFACLCQAARSQNDYLALAERFHTVFLEDVPQMTRCSDDAARRFIALVDE 313
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 16131122   324 FYERHVKLVVSAEVPLYEIYQGDRLKFEFQRCLSRLQEMQSEEYLKRE 371
Cdd:pfam03969 314 LYDRDVKLVASAEVELSDLYLGGRLEFEFQRTLSRLLEMQSHDYLARE 361
ZapE NF040713
cell division protein ZapE;
9-363 0e+00

cell division protein ZapE;


Pssm-ID: 468677 [Multi-domain]  Cd Length: 344  Bit Score: 529.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131122    9 QYLKALNEGSHQPDDVQKEAVSRLEIIYQELINstpPAPRTSGLmarvGKLWGKREDtkhtPVRGLYMWGGVGRGKTWLM 88
Cdd:NF040713   1 RYEAAVAFGGYRPDPAQAAAVERLDRLAEELAA---PAKKRGLL----GRLFGRKKS----PPRGLYLWGGVGRGKTMLM 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131122   89 DLFYQSLPGERKQRLHFHRFMLRVHEELTALQGQTDPLEIIADRFKAETDVLCFDEFFVSDITDAMLLGGLMKALFARGI 168
Cdd:NF040713  70 DLFYEALPIERKRRVHFHEFMREVHQRLALLRGQADPLPPVADEIASEARLLCFDEFHVDDIADAMILGRLFEALFERGV 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131122  169 TLVATSNIPPDELYRNGLQRARFLPAIDAIKQHCDVMNVDAGVDYRLRTLTQAHLWLSPLHDETRAQMDKLWLALAGGKR 248
Cdd:NF040713 150 VLVATSNTPPDDLYKNGLNRERFLPAIALIKAHFDVVNVDGGTDYRLRRLEQAPVYLTPLDAEADAALDAAFARLTGGAA 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131122  249 ENSPTLEINHRPLATMGVENQTLAVSFTTLCVDARSQHDYIALSRLFHTVMLFDVPVMTRLMESEARRFIALVDEFYERH 328
Cdd:NF040713 230 AEPGTLEVNGRELPVPRAAGGVAWFDFADLCEAPRSPSDYLALARRFHTVLLSGVPPLGDESRDAARRFIALIDELYDRK 309
                        330       340       350
                 ....*....|....*....|....*....|....*
gi 16131122  329 VKLVVSAEVPLYEIYQGDRLKFEFQRCLSRLQEMQ 363
Cdd:NF040713 310 VKLIISAEVPLEELYTEGGLAFEFERTLSRLQEMQ 344
 
Name Accession Description Interval E-value
ZapE COG1485
Cell division protein ZapE (Z ring-associated ATPase), AFG1 superfamily [Cell cycle control, ...
2-374 0e+00

Cell division protein ZapE (Z ring-associated ATPase), AFG1 superfamily [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441094  Cd Length: 365  Bit Score: 624.81  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131122   2 QSVTPTSQYLKALNEGSHQPDDVQKEAVSRLEIIYQELINstPPAPRTSGLmarvGKLWGKREdtKHTPVRGLYMWGGVG 81
Cdd:COG1485   1 MMMSPLERYQALLAAGGLQPDPAQEAAVARLDRLYDELLA--YRPRKSGLL----GRLFGRKR--KPEPPKGLYLWGGVG 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131122  82 RGKTWLMDLFYQSLPGERKQRLHFHRFMLRVHEELTALQGQTDPLEIIADRFKAETDVLCFDEFFVSDITDAMLLGGLMK 161
Cdd:COG1485  73 RGKTMLMDLFFESLPVERKRRVHFHRFMQEVHARLHALRGQADPLPPVADRIAAEARLLCFDEFHVTDIADAMILGRLFE 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131122 162 ALFARGITLVATSNIPPDELYRNGLQRARFLPAIDAIKQHCDVMNVDAGVDYRLRTLTQAHLWLSPLHDETRAQMDKLWL 241
Cdd:COG1485 153 ALFARGVVLVATSNIPPDDLYKNGLQRARFLPFIALIKQHLDVLNLDSGTDYRLRRLEGAPVYHTPLDAEADAALDAAFA 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131122 242 ALAGGKRENSPTLEINHRPLATMGVENQTLAVSFTTLCVDARSQHDYIALSRLFHTVMLFDVPVMTRLMESEARRFIALV 321
Cdd:COG1485 233 RLTGGAPEEPETLEVNGREIPVPRAAGGVAWFDFADLCGGPRGQADYLELARRFHTVILSDVPVMGPDNRNEARRFITLI 312
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|...
gi 16131122 322 DEFYERHVKLVVSAEVPLYEIYQGDRLKFEFQRCLSRLQEMQSEEYLKREHLA 374
Cdd:COG1485 313 DELYDRRVKLIASAAAPPEELYTGGRGAFEFERTASRLIEMQSEEYLALPHRP 365
AFG1_ATPase pfam03969
AFG1-like ATPase; This P-loop motif-containing family of proteins includes AFG1, LACE1 and ...
4-371 0e+00

AFG1-like ATPase; This P-loop motif-containing family of proteins includes AFG1, LACE1 and ZapE. ATPase family gene 1 (AFG1) is a 377 amino acid yeast protein with an ATPase motif typical of the family. LACE1, the mammalian homolog of AFG1, is a mitochondrial integral membrane protein that is essential for maintenance of fused mitochondrial reticulum and lamellar cristae morphology. It has also been demonstrated that LACE1 mediates degradation of nuclear-encoded complex IV subunits COX4 (cytochrome c oxidase 4), COX5A and COX6A, and is required for normal activity of complexes III and IV of the respiratory chain. ZapE is a cell division protein found in Gram-negative bacteria. The bacterial cell division process relies on the assembly, positioning, and constriction of FtsZ ring (the so-called Z-ring), a ring-like network that marks the future site of the septum of bacterial cell division. ZapE is a Z-ring associated protein required for cell division under low-oxygen conditions. It is an ATPase that appears at the constricting Z-ring late in cell division. It reduces the stability of FtsZ polymers in the presence of ATP in vitro.


Pssm-ID: 397872  Cd Length: 361  Bit Score: 590.24  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131122     4 VTPTSQYLKALNEGSHQPDDVQKEAVSRLEIIYQELINSTPPAPRtsglmARVGKLWGKREDtkHTPVRGLYMWGGVGRG 83
Cdd:pfam03969   1 TTPPVRYIADLQRPDFFPDVAQANAVPHLDRLYQDLAAQDFPRPA-----RAGGKLWGRKPS--VQPPRGLYLWGGVGRG 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131122    84 KTWLMDLFYQSLPGERKQRLHFHRFMLRVHEELTALQGQTDPLEIIADRFKAETDVLCFDEFFVSDITDAMLLGGLMKAL 163
Cdd:pfam03969  74 KTWLMDLFFESLPGEKKRRTHFHRFMFRVHDELTTLQGGVDPLAIIADRLAGEARLLCFDEFFVSDIGDAMLLGRLFEAL 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131122   164 FARGITLVATSNIPPDELYRNGLQRARFLPAIDAIKQHCDVMNVDAGVDYRLRTLTQAHLWLSPLHDETRAQMDKLWLAL 243
Cdd:pfam03969 154 FARGVTLVATSNIAPEQLYKNGLQRARFLPAIDLLKSHCEVVNVDGGVDYRLRTLRQAELWLYPLDGYCWAAMDRLWDAL 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131122   244 AGGKRENSPTLEINHRPLATMGVENQTLAVSFTTLCVDARSQHDYIALSRLFHTVMLFDVPVMTRLMESEARRFIALVDE 323
Cdd:pfam03969 234 GLGEPEPLSTLEVNARALRARAVGGDLVWFSFACLCQAARSQNDYLALAERFHTVFLEDVPQMTRCSDDAARRFIALVDE 313
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 16131122   324 FYERHVKLVVSAEVPLYEIYQGDRLKFEFQRCLSRLQEMQSEEYLKRE 371
Cdd:pfam03969 314 LYDRDVKLVASAEVELSDLYLGGRLEFEFQRTLSRLLEMQSHDYLARE 361
ZapE NF040713
cell division protein ZapE;
9-363 0e+00

cell division protein ZapE;


Pssm-ID: 468677 [Multi-domain]  Cd Length: 344  Bit Score: 529.01  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131122    9 QYLKALNEGSHQPDDVQKEAVSRLEIIYQELINstpPAPRTSGLmarvGKLWGKREDtkhtPVRGLYMWGGVGRGKTWLM 88
Cdd:NF040713   1 RYEAAVAFGGYRPDPAQAAAVERLDRLAEELAA---PAKKRGLL----GRLFGRKKS----PPRGLYLWGGVGRGKTMLM 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131122   89 DLFYQSLPGERKQRLHFHRFMLRVHEELTALQGQTDPLEIIADRFKAETDVLCFDEFFVSDITDAMLLGGLMKALFARGI 168
Cdd:NF040713  70 DLFYEALPIERKRRVHFHEFMREVHQRLALLRGQADPLPPVADEIASEARLLCFDEFHVDDIADAMILGRLFEALFERGV 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131122  169 TLVATSNIPPDELYRNGLQRARFLPAIDAIKQHCDVMNVDAGVDYRLRTLTQAHLWLSPLHDETRAQMDKLWLALAGGKR 248
Cdd:NF040713 150 VLVATSNTPPDDLYKNGLNRERFLPAIALIKAHFDVVNVDGGTDYRLRRLEQAPVYLTPLDAEADAALDAAFARLTGGAA 229
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131122  249 ENSPTLEINHRPLATMGVENQTLAVSFTTLCVDARSQHDYIALSRLFHTVMLFDVPVMTRLMESEARRFIALVDEFYERH 328
Cdd:NF040713 230 AEPGTLEVNGRELPVPRAAGGVAWFDFADLCEAPRSPSDYLALARRFHTVLLSGVPPLGDESRDAARRFIALIDELYDRK 309
                        330       340       350
                 ....*....|....*....|....*....|....*
gi 16131122  329 VKLVVSAEVPLYEIYQGDRLKFEFQRCLSRLQEMQ 363
Cdd:NF040713 310 VKLIISAEVPLEELYTEGGLAFEFERTLSRLQEMQ 344
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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