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Conserved domains on  [gi|90111567|ref|NP_417736|]
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putative ABC transporter membrane subunit YhdY [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

amino acid ABC transporter permease( domain architecture ID 11433582)

amino acid ABC transporter permease is the transmembrane (TM) subunit of a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter which binds and transports amino acids

Gene Ontology:  GO:0140359|GO:0042626|GO:0006865
PubMed:  25750732|24638992
TCDB:  3.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 156-364 5.48e-75

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


:

Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 231.12  E-value: 5.48e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567 156 WGGLTLTLIIASVGIAGALPWGILLALGRRSHMPIVRILSVIFIEFWRGVPLITVLFMSSVMLPLFmaeGTSIDKLIRAL 235
Cdd:COG0765  16 LEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLL---GIDLSPFVAAV 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567 236 VGVILFQSAYVAEVVRGGLQALPKGQYEAAESLALGYWKTQGLVILPQALKLVIPGLVNTIIALFKDTSLVIIIGLFDLF 315
Cdd:COG0765  93 IALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVSVIGVPELT 172

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 90111567 316 SSVQQATVDpawLGMSTEGYVFAALIYWIFCFSMSRYSQYLEKRFNTGR 364
Cdd:COG0765 173 RAAQQIASR---TFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARGR 218
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 156-364 5.48e-75

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 231.12  E-value: 5.48e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567 156 WGGLTLTLIIASVGIAGALPWGILLALGRRSHMPIVRILSVIFIEFWRGVPLITVLFMSSVMLPLFmaeGTSIDKLIRAL 235
Cdd:COG0765  16 LEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLL---GIDLSPFVAAV 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567 236 VGVILFQSAYVAEVVRGGLQALPKGQYEAAESLALGYWKTQGLVILPQALKLVIPGLVNTIIALFKDTSLVIIIGLFDLF 315
Cdd:COG0765  93 IALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVSVIGVPELT 172

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 90111567 316 SSVQQATVDpawLGMSTEGYVFAALIYWIFCFSMSRYSQYLEKRFNTGR 364
Cdd:COG0765 173 RAAQQIASR---TFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARGR 218
PRK15100 PRK15100
cystine ABC transporter permease;
158-364 2.00e-32

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 121.01  E-value: 2.00e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567  158 GLTLTLIIASVGIAGALPWGILLALGRRSHMPIVRILSVIFIEFWRGVPLITVLFMSSVMLPLFmaeGTSIDKLIRALVG 237
Cdd:PRK15100  18 GAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQF---GIELDPIPAAMIG 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567  238 VILFQSAYVAEVVRGGLQALPKGQYEAAESLALGYWKTQGLVILPQALKLVIPGLVNTIIALFKDTSLVIIIGLFDLFSS 317
Cdd:PRK15100  95 LSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQVPELFRQ 174

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 90111567  318 VQQATVDPawLGMSTEgYVFAALIYWIFCFSMSRYSQYLEKRFNTGR 364
Cdd:PRK15100 175 AQLITSRT--LEVFTM-YLAASLIYWIMATVLSALQNRFENQLNRQE 218
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 158-359 2.14e-22

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 93.76  E-value: 2.14e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567   158 GLTLTLIIASVGIAGALPWGILLALGRRSH-MPIVRILSVIfIEFWRGVPLITVLFMSSVMLPLFmaeGTSIDKLIRALV 236
Cdd:TIGR03003  16 GLKITILATALGFAIAAVLGLVFAILRRSApTPISWPTSFV-VEFIRGTPLLVQLYFLYYVLPDI---GIRLPALVAGVL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567   237 GVILFQSAYVAEVVRGGLQALPKGQYEAAESLALGYWKTQGLVILPQALKLVIPGLVNTIIALFKDTSLVIIIGLFDLfs 316
Cdd:TIGR03003  92 GLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVLSAITVLEL-- 169

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 90111567   317 sVQQATVdpawLGMSTEGYVFAALIYWIFCFSMSRYSQYLEKR 359
Cdd:TIGR03003 170 -MNQAKS----IGNSTFRYLEPMTLVGVFFLILSIISVFFLRR 207
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 159-350 5.96e-19

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 83.48  E-value: 5.96e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567 159 LTLTLIIASVGIAGALPWGILLALGRRSHMPIVRILSVIFIEFWRGVPLITVLFMSSVMLPLFMAEGTSIDKLIRALVGV 238
Cdd:cd06261   1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGLGLPALILA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567 239 ILFQSAYVAEVVRGGLQALPKGQYEAAESLALGYWKTQGLVILPQALKLVIPGLVNTIIALFKDTSLVIIIGLFDLFSSV 318
Cdd:cd06261  81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                       170       180       190
                ....*....|....*....|....*....|..
gi 90111567 319 QQATvdpAWLGMSTEGYVFAALIYWIFCFSMS 350
Cdd:cd06261 161 TGLL---LIFAILFPGDLGVAAAVALILLLLS 189
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 173-360 4.90e-15

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 72.33  E-value: 4.90e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567   173 ALPWGILLALGRRShmpIVRILSVIFIEFWRGVPLItVLFMSSVMLPLFMAEGTSIdklIRALVGVILFQSAYVAEVVRG 252
Cdd:pfam00528   1 GIPLGIIAALRRGR---RLDRLLRPLIDLLQALPSF-VLAILLVVIAILSILGHGI---LPAIILALLGWAGYARLIRRA 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567   253 GLQALPKGQYEAAESLALGYWKTQGLVILPQALKLVIPGLVNTIIALFKDTSLVIIIGLFDLFSSVQQATVDPAWLGMST 332
Cdd:pfam00528  74 ALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYPEIQ 153

                         170       180
                  ....*....|....*....|....*...
gi 90111567   333 EGYVFAALIYWIFCFSMSRYSQYLEKRF 360
Cdd:pfam00528 154 GPVLAAALILLLLNLLVDILQRLLDPRV 181
 
Name Accession Description Interval E-value
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 156-364 5.48e-75

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 231.12  E-value: 5.48e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567 156 WGGLTLTLIIASVGIAGALPWGILLALGRRSHMPIVRILSVIFIEFWRGVPLITVLFMSSVMLPLFmaeGTSIDKLIRAL 235
Cdd:COG0765  16 LEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPLL---GIDLSPFVAAV 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567 236 VGVILFQSAYVAEVVRGGLQALPKGQYEAAESLALGYWKTQGLVILPQALKLVIPGLVNTIIALFKDTSLVIIIGLFDLF 315
Cdd:COG0765  93 IALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNEFISLLKDTSLVSVIGVPELT 172

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 90111567 316 SSVQQATVDpawLGMSTEGYVFAALIYWIFCFSMSRYSQYLEKRFNTGR 364
Cdd:COG0765 173 RAAQQIASR---TFRPFEVYLVAALIYLVLTLPLSLLARRLERRLARGR 218
PRK15100 PRK15100
cystine ABC transporter permease;
158-364 2.00e-32

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 121.01  E-value: 2.00e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567  158 GLTLTLIIASVGIAGALPWGILLALGRRSHMPIVRILSVIFIEFWRGVPLITVLFMSSVMLPLFmaeGTSIDKLIRALVG 237
Cdd:PRK15100  18 GAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQF---GIELDPIPAAMIG 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567  238 VILFQSAYVAEVVRGGLQALPKGQYEAAESLALGYWKTQGLVILPQALKLVIPGLVNTIIALFKDTSLVIIIGLFDLFSS 317
Cdd:PRK15100  95 LSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQVPELFRQ 174

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 90111567  318 VQQATVDPawLGMSTEgYVFAALIYWIFCFSMSRYSQYLEKRFNTGR 364
Cdd:PRK15100 175 AQLITSRT--LEVFTM-YLAASLIYWIMATVLSALQNRFENQLNRQE 218
ArtQ COG4215
ABC-type arginine transport system, permease component [Amino acid transport and metabolism];
156-363 1.55e-28

ABC-type arginine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443361 [Multi-domain]  Cd Length: 238  Bit Score: 110.98  E-value: 1.55e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567 156 WGGLTLTLIIASVGIAGALPWGILLALGRRSHMPIVRILSVIFIEFWRGVP-LITVLF--------MSSVMLPLFMAEGT 226
Cdd:COG4215  19 LAGALVTLELALLSLLLGLVLGLLGALAKLSGNRPLRWLATGYTTVVRGVPdLLLILLlyfggqilLNALADLFGYDGFI 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567 227 SIDKLIRALVGVILFQSAYVAEVVRGGLQALPKGQYEAAESLALGYWKTQGLVILPQALKLVIPGLVNTIIALFKDTSLV 306
Cdd:COG4215  99 EINPFVAGVLALGFVFGAYATEVFRGAFLAVPKGQIEAARAYGMSRWQVFRRILLPQMWRYALPGLGNNWLVLLKDTALV 178

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567 307 IIIGLFDLFSSVQQA---TVDPAWLgmstegYVFAALIYWIFCFSMSRYSQYLEKRFNTG 363
Cdd:COG4215 179 SVIGLVDLVRQAQEAagsTREPFTF------YLAAALIYLALTTVSELVLARLERRASRG 232
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
156-359 8.24e-28

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 108.76  E-value: 8.24e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567  156 WGGLTLTLIIASVGIAGALPWGILLALGRRSHMPIVRILSVIFIEFWRGVPLITVLFMSSVMLPLFMAEGTSID-----K 230
Cdd:PRK15107  17 LDGLVITLKITVTAVVIGILWGTILAVMRLSSFKPVAWFAKAYVNVFRSIPLVMVLLWFYLIVPGFLQNVLGLSpktdiR 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567  231 LIRALVGVILFQSAYVAEVVRGGLQALPKGQYEAAESLALGYWKTQGLVILPQALKLVIPGLVNTIIALFKDTSLVIIIG 310
Cdd:PRK15107  97 LISAMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVLFQDTSLVYVLS 176

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 90111567  311 LFDLFSSvqqATVDPAWLGMSTEGYVFAALIYWIFCFSMSRYSQYLEKR 359
Cdd:PRK15107 177 LADFFRT---ASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYLKKR 222
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 158-359 3.94e-23

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 95.89  E-value: 3.94e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567  158 GLTLTLIIASVGIAGALPWGILLALGRRSHMPIVRILSVIFIEFWRGVPLITVLFMSSVMLPLfMAEGTSIDKLIRALVG 237
Cdd:PRK09494  18 GAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFALPM-AFNDLRIDPFTAAVVT 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567  238 VILFQSAYVAEVVRGGLQALPKGQYEAAESLALGYWKTQGLVILPQALKLVIPGLVNTIIALFKDTSLVIIIGLFDLFSS 317
Cdd:PRK09494  97 IMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIKDTSLFIVIGVAELTRQ 176

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 90111567  318 VQQATvdpAWLGMSTEGYVFAALIYWIFCFSMSRYSQYLEKR 359
Cdd:PRK09494 177 GQEII---AGNFRALEIWSAVAVIYLIITLVLSFILRRLERR 215
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 158-359 2.14e-22

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 93.76  E-value: 2.14e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567   158 GLTLTLIIASVGIAGALPWGILLALGRRSH-MPIVRILSVIfIEFWRGVPLITVLFMSSVMLPLFmaeGTSIDKLIRALV 236
Cdd:TIGR03003  16 GLKITILATALGFAIAAVLGLVFAILRRSApTPISWPTSFV-VEFIRGTPLLVQLYFLYYVLPDI---GIRLPALVAGVL 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567   237 GVILFQSAYVAEVVRGGLQALPKGQYEAAESLALGYWKTQGLVILPQALKLVIPGLVNTIIALFKDTSLVIIIGLFDLfs 316
Cdd:TIGR03003  92 GLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVLSAITVLEL-- 169

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 90111567   317 sVQQATVdpawLGMSTEGYVFAALIYWIFCFSMSRYSQYLEKR 359
Cdd:TIGR03003 170 -MNQAKS----IGNSTFRYLEPMTLVGVFFLILSIISVFFLRR 207
BatB COG4597
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 157-316 4.20e-20

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443651 [Multi-domain]  Cd Length: 397  Bit Score: 90.59  E-value: 4.20e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567 157 GGLTLTLIIASVGIAGALPWGI-----LLALGRRSHMPIVRILSVIfiefwrGVPLITVLFMSSVM------LPLFMAEG 225
Cdd:COG4597 184 PGFGWVLAALLAAIVAAFVLRRwarrrQEATGQRFPVWWISLALLV------GLPLLAFLLLGAPLsldypeLKGFNFRG 257

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567 226 --TSIDKLIRALVGVILFQSAYVAEVVRGGLQALPKGQYEAAESLALGYWKTQGLVILPQALKLVIPGLVNTIIALFKDT 303
Cdd:COG4597 258 glTLSPEFVALLLALSLYTAAFIAEIVRAGIQAVSKGQTEAARALGLRPGQTLRLVVLPQALRVIIPPLTSQYLNLTKNS 337

                       170
                ....*....|...
gi 90111567 304 SLVIIIGLFDLFS 316
Cdd:COG4597 338 SLAVAIGYPDLVS 350
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 159-350 5.96e-19

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 83.48  E-value: 5.96e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567 159 LTLTLIIASVGIAGALPWGILLALGRRSHMPIVRILSVIFIEFWRGVPLITVLFMSSVMLPLFMAEGTSIDKLIRALVGV 238
Cdd:cd06261   1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGLGLPALILA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567 239 ILFQSAYVAEVVRGGLQALPKGQYEAAESLALGYWKTQGLVILPQALKLVIPGLVNTIIALFKDTSLVIIIGLFDLFSSV 318
Cdd:cd06261  81 LLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGEAPGPG 160

                       170       180       190
                ....*....|....*....|....*....|..
gi 90111567 319 QQATvdpAWLGMSTEGYVFAALIYWIFCFSMS 350
Cdd:cd06261 161 TGLL---LIFAILFPGDLGVAAAVALILLLLS 189
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 156-252 6.21e-18

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 77.96  E-value: 6.21e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567   156 WGGLTLTLIIASVGIAGALPWGILLALGRRSHMPIVRILSVIFIEFWRGVPLITVLFMSSVMLPLFmaeGTSIDKLIRAL 235
Cdd:TIGR01726   6 LKGLLLTLLLSVLSILLGLVLGLLLALLRLSGNRPLRWIATVYVELFRGTPLLVQLFFIYFGLPLI---GIRLSPLTAAV 82

                          90
                  ....*....|....*..
gi 90111567   236 VGVILFQSAYVAEVVRG 252
Cdd:TIGR01726  83 IALTLFYGAYLAEIFRG 99
PRK11123 PRK11123
arginine ABC transporter permease ArtQ;
158-359 6.62e-16

arginine ABC transporter permease ArtQ;


Pssm-ID: 182979 [Multi-domain]  Cd Length: 238  Bit Score: 76.25  E-value: 6.62e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567  158 GLTLTLIIASVGIAGALpwGILLALGRRSHMPIVRILSVIFIEFWRGVPLITVL----FMSSVMLPLFMAEGTSIDKLIR 233
Cdd:PRK11123  12 GMTVGLAVCALIVGLAL--AMLFAVWESAKWRPVAWPGTALVTLLRGLPEILVVlfiyFGSSQLLLTLSDGFTLNLGFVQ 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567  234 A--------------LVGVI---LFQSAYVAEVVRGGLQALPKGQYEAAESLALGYWKTQGLVILPQALKLVIPGLVNTI 296
Cdd:PRK11123  90 IpvqmdienfevspfLCGVIalsLLYAAYASQTLRGALKAVPVGQWESGQALGLSKSAIFFRLVMPQMWRHALPGLGNQW 169

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 90111567  297 IALFKDTSLVIIIGLFDLF---SSVQQATVDP-AWlgmstegYVFAALIYWIfcfsMSRYSQYLEKR 359
Cdd:PRK11123 170 LVLLKDTALVSLISVNDLMlqtKSIATRTQEPfTW-------YIIAAAIYLV----ITLISQYILKR 225
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 173-360 4.90e-15

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 72.33  E-value: 4.90e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567   173 ALPWGILLALGRRShmpIVRILSVIFIEFWRGVPLItVLFMSSVMLPLFMAEGTSIdklIRALVGVILFQSAYVAEVVRG 252
Cdd:pfam00528   1 GIPLGIIAALRRGR---RLDRLLRPLIDLLQALPSF-VLAILLVVIAILSILGHGI---LPAIILALLGWAGYARLIRRA 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567   253 GLQALPKGQYEAAESLALGYWKTQGLVILPQALKLVIPGLVNTIIALFKDTSLVIIIGLFDLFSSVQQATVDPAWLGMST 332
Cdd:pfam00528  74 ALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLGSWPGLGLLLIEAILGYDYPEIQ 153

                         170       180
                  ....*....|....*....|....*...
gi 90111567   333 EGYVFAALIYWIFCFSMSRYSQYLEKRF 360
Cdd:pfam00528 154 GPVLAAALILLLLNLLVDILQRLLDPRV 181
PRK15069 PRK15069
histidine ABC transporter permease HisM;
159-359 2.01e-11

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 63.15  E-value: 2.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567  159 LTLTLIIASVGIAGALpwGILLALGRRSHMPIVRILSVIFIEFWRGVPL-ITVLFMSSVMLPLFMAEGTSI-DKLIR--- 233
Cdd:PRK15069  25 ITLWLLVASVVIGFVL--AVPLAIARVSSNKWIRFPVWLYTYVFRGTPLyVQLLVFYTGMYSLEIVRGTDLlDAFFRsgl 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567  234 --ALVGVILFQSAYVAEVVRGGLQALPKGQYEAAESLALGYWKTQGLVILPQALKLVIPGLVNTIIALFKDTSLVIIIGL 311
Cdd:PRK15069 103 ncTILAFTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRALPAYSNEVILMLHATTLAFTATV 182

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 90111567  312 FDLFS---SVQQATVdpawlgMSTEGYVFAALIYWIFCFSMSRYSQYLEKR 359
Cdd:PRK15069 183 PDILKiarDINSATY------QPFQAFGIAAVLYLIISFVLISLFRRAERR 227
PRK15135 PRK15135
histidine ABC transporter permease HisQ;
159-363 2.64e-09

histidine ABC transporter permease HisQ;


Pssm-ID: 185089 [Multi-domain]  Cd Length: 228  Bit Score: 56.73  E-value: 2.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567  159 LTLTLIIASVGIAGALpwGILLALGRRSHMPIVRILSVIFIEFWRGVP---LITVLF------MSSVMLPLFMAEgTSID 229
Cdd:PRK15135  15 VTLELALSSVVLAVII--GLIGAGGKLSQNRLLGLIFEGYTTLIRGVPdlvLMLLIFyglqiaLNSVTEALGVGQ-IDID 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567  230 KLIRALVGVILFQSAYVAEVVRGGLQALPKGQYEAAESLALGYWKTQGLVILPQALKLVIPGLVNTIIALFKDTSLVIII 309
Cdd:PRK15135  92 PMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQVILKATALVSLL 171

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 90111567  310 GLFDLFSSVQQA---TVDPAWLGmstegyVFAALIYWIFCFSMSRYSQYLEKRFNTG 363
Cdd:PRK15135 172 GLEDVVKATQLAgksTWEPFYFA------IVCGVIYLVFTTVSNGVLLWLERRYSVG 222
artM PRK11122
arginine ABC transporter permease ArtM;
159-320 1.99e-08

arginine ABC transporter permease ArtM;


Pssm-ID: 182978 [Multi-domain]  Cd Length: 222  Bit Score: 54.19  E-value: 1.99e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567  159 LTLTLIIASVGIAGALPWGILLALGRrshmPIVRILSVIFIEFWRGVPLITVLFM-------------SSVMLPLFMaeg 225
Cdd:PRK11122  16 LTLTVASLLVALVLALIFTIILTLKT----PVLVWLVRGYITLFTGTPLLVQIFLiyygpgqfpwlqeYPWLWHLLS--- 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567  226 tsiDKLIRALVGVILFQSAYVAEVVRGGLQALPKGQYEAAEslALGYWKTQGL-VILPQALKLVIPGLVNTIIALFKDTS 304
Cdd:PRK11122  89 ---QPWLCAMLALALNSAAYSTQLFYGAVRAIPEGQWQSCA--ALGMSKKQTLrILLPYAFKRALSSYSNEVVLVFKSTS 163

                        170
                 ....*....|....*.
gi 90111567  305 LVIIIGLFDLFSSVQQ 320
Cdd:PRK11122 164 LAYTITLMDVMGYSQL 179
PRK10782 PRK10782
D-methionine ABC transporter permease MetI;
156-299 1.39e-05

D-methionine ABC transporter permease MetI;


Pssm-ID: 182726  Cd Length: 217  Bit Score: 45.49  E-value: 1.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567  156 WGGLTLTLIIASVGIAGALPWGILLALGRRSHM----PIVRILSVIfIEFWRGVPLITVLFMssvMLPLF-MAEGTSIDk 230
Cdd:PRK10782  14 WETLAMTFVSGFFGFVIGLPVGVLLYVTRPGQIianaKLYRTLSAL-VNIFRSIPFIILLVW---MIPFTrVIVGTSIG- 88

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 90111567  231 LIRALVGVILFQSAYVAEVVRGGLQALPKGQYEAAESLALGYWKTQGLVILPQALklviPGLVN----TIIAL 299
Cdd:PRK10782  89 LQAAIVPLTVGAAPFIARMVENALLEIPTGLIEASRAMGATPMQIVRKVLLPEAL----PGLVNaatiTLITL 157
PotC COG1177
ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport ...
 142-293 2.41e-03

ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism];


Pssm-ID: 440790 [Multi-domain]  Cd Length: 262  Bit Score: 39.32  E-value: 2.41e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567 142 YGGFFALERVetrqWGGLTLTLIIASVGIAGALPWGILLALG-RRSHMPIVRILSVIFIefwrgVPLIT---VLFMSsvM 217
Cdd:COG1177  50 YAELFSDPRL----LDALLNSLLIALLSTLLATVLGTPAALAlARYRFRGRRLLLALLL-----LPLVVpgiVLGVA--L 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111567 218 LPLFMAEGtsidkLIRALVGVIL----FQSAYVAEVVRGGLQALPKGQYEAAESLALGYWKTQGLVILPQALklviPGLV 293
Cdd:COG1177 119 LLLFSALG-----LSGGLWGLILahvvFTLPFVVLVVLARLQGFDPSLEEAARDLGASPWQTFRRVTLPLIA----PGIL 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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