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Conserved domains on  [gi|90111573|ref|NP_417805|]
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DNA-binding transcriptional regulator YheO [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

transcriptional regulator( domain architecture ID 11459460)

transcriptional regulator containing a PAS and a DNA-binding helix-turn-helix domain

Gene Ontology:  GO:0003677|GO:0140110

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
YheO COG2964
Predicted transcriptional regulator YheO, contains PAS and DNA-binding HTH domains ...
23-232 2.79e-93

Predicted transcriptional regulator YheO, contains PAS and DNA-binding HTH domains [Transcription];


:

Pssm-ID: 442204 [Multi-domain]  Cd Length: 214  Bit Score: 272.87  E-value: 2.79e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111573  23 QTDFDILKSYEAVVDGLAMLIGSHCEIVLHSLQDLKCSAIRIANGEHTGRKIGSPITDLALRMLHDMTGADSSVSKCYFT 102
Cdd:COG2964   3 KEDKELLESYIPIADGLAALFGPNCEVVLHDLEDPEHSIVAIANGHVSGRKVGDPITDLGLELLKDGAYEDPDVIGNYET 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111573 103 RAKSGVLMKSLTIAIRNREQRVIGLLCINMNLD--VPFSQIMSTFVPPETPDVGSSVNFASSVEDLVTQTLEFTIEEVNA 180
Cdd:COG2964  83 RTKDGRLLKSSTIFIRDEKGKPIGALCINFDLSkfEAAQNFLDSFLPTDDSEEEPPENFASDVEELIDEIIDEALAEVGK 162
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 90111573 181 DRNVSNNAKNRQIVLNLYEKGIFDIKDAINQVADRLNISKHTVYLYIRQFKS 232
Cdd:COG2964 163 PPSALSKEEKIEIVRELDEKGIFLIKGAVDYVAKRLGISRATVYNYLREIKK 214
 
Name Accession Description Interval E-value
YheO COG2964
Predicted transcriptional regulator YheO, contains PAS and DNA-binding HTH domains ...
23-232 2.79e-93

Predicted transcriptional regulator YheO, contains PAS and DNA-binding HTH domains [Transcription];


Pssm-ID: 442204 [Multi-domain]  Cd Length: 214  Bit Score: 272.87  E-value: 2.79e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111573  23 QTDFDILKSYEAVVDGLAMLIGSHCEIVLHSLQDLKCSAIRIANGEHTGRKIGSPITDLALRMLHDMTGADSSVSKCYFT 102
Cdd:COG2964   3 KEDKELLESYIPIADGLAALFGPNCEVVLHDLEDPEHSIVAIANGHVSGRKVGDPITDLGLELLKDGAYEDPDVIGNYET 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111573 103 RAKSGVLMKSLTIAIRNREQRVIGLLCINMNLD--VPFSQIMSTFVPPETPDVGSSVNFASSVEDLVTQTLEFTIEEVNA 180
Cdd:COG2964  83 RTKDGRLLKSSTIFIRDEKGKPIGALCINFDLSkfEAAQNFLDSFLPTDDSEEEPPENFASDVEELIDEIIDEALAEVGK 162
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 90111573 181 DRNVSNNAKNRQIVLNLYEKGIFDIKDAINQVADRLNISKHTVYLYIRQFKS 232
Cdd:COG2964 163 PPSALSKEEKIEIVRELDEKGIFLIKGAVDYVAKRLGISRATVYNYLREIKK 214
PAS_6 pfam08348
YheO-like PAS domain; This family contains various hypothetical bacterial proteins that are ...
29-139 3.54e-47

YheO-like PAS domain; This family contains various hypothetical bacterial proteins that are similar to the E. coli protein YheO. Their function is unknown, but are likely to be involved in signalling based on the presence of this PAS domain.


Pssm-ID: 429938 [Multi-domain]  Cd Length: 115  Bit Score: 151.90  E-value: 3.54e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111573    29 LKSYEAVVDGLAMLIGSHCEIVLHSLQDLKCSAIRIANGEHTGRKIGSPITDLALRMLHDMTGADSSVSKCYFTRAKSGV 108
Cdd:pfam08348   1 LESYIPIADGLAETFGPNCEVVLHDLRDPEHSIVAIANGHVTGRKVGDPITDLALELLKQEEYEEKDYLINYKTKTKDGR 80
                          90       100       110
                  ....*....|....*....|....*....|.
gi 90111573   109 LMKSLTIAIRNREQRVIGLLCINMNLDVPFS 139
Cdd:pfam08348  81 ILKSSTIFIRDEDGKIIGLLCINFDITALLA 111
 
Name Accession Description Interval E-value
YheO COG2964
Predicted transcriptional regulator YheO, contains PAS and DNA-binding HTH domains ...
23-232 2.79e-93

Predicted transcriptional regulator YheO, contains PAS and DNA-binding HTH domains [Transcription];


Pssm-ID: 442204 [Multi-domain]  Cd Length: 214  Bit Score: 272.87  E-value: 2.79e-93
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111573  23 QTDFDILKSYEAVVDGLAMLIGSHCEIVLHSLQDLKCSAIRIANGEHTGRKIGSPITDLALRMLHDMTGADSSVSKCYFT 102
Cdd:COG2964   3 KEDKELLESYIPIADGLAALFGPNCEVVLHDLEDPEHSIVAIANGHVSGRKVGDPITDLGLELLKDGAYEDPDVIGNYET 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111573 103 RAKSGVLMKSLTIAIRNREQRVIGLLCINMNLD--VPFSQIMSTFVPPETPDVGSSVNFASSVEDLVTQTLEFTIEEVNA 180
Cdd:COG2964  83 RTKDGRLLKSSTIFIRDEKGKPIGALCINFDLSkfEAAQNFLDSFLPTDDSEEEPPENFASDVEELIDEIIDEALAEVGK 162
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 90111573 181 DRNVSNNAKNRQIVLNLYEKGIFDIKDAINQVADRLNISKHTVYLYIRQFKS 232
Cdd:COG2964 163 PPSALSKEEKIEIVRELDEKGIFLIKGAVDYVAKRLGISRATVYNYLREIKK 214
PAS_6 pfam08348
YheO-like PAS domain; This family contains various hypothetical bacterial proteins that are ...
29-139 3.54e-47

YheO-like PAS domain; This family contains various hypothetical bacterial proteins that are similar to the E. coli protein YheO. Their function is unknown, but are likely to be involved in signalling based on the presence of this PAS domain.


Pssm-ID: 429938 [Multi-domain]  Cd Length: 115  Bit Score: 151.90  E-value: 3.54e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111573    29 LKSYEAVVDGLAMLIGSHCEIVLHSLQDLKCSAIRIANGEHTGRKIGSPITDLALRMLHDMTGADSSVSKCYFTRAKSGV 108
Cdd:pfam08348   1 LESYIPIADGLAETFGPNCEVVLHDLRDPEHSIVAIANGHVTGRKVGDPITDLALELLKQEEYEEKDYLINYKTKTKDGR 80
                          90       100       110
                  ....*....|....*....|....*....|.
gi 90111573   109 LMKSLTIAIRNREQRVIGLLCINMNLDVPFS 139
Cdd:pfam08348  81 ILKSSTIFIRDEDGKIIGLLCINFDITALLA 111
HTH_22 pfam13309
HTH domain; This domain is a helix-turn-helix domain that is likely to act as a DNA-binding ...
170-228 6.30e-20

HTH domain; This domain is a helix-turn-helix domain that is likely to act as a DNA-binding domain.


Pssm-ID: 463841 [Multi-domain]  Cd Length: 63  Bit Score: 80.20  E-value: 6.30e-20
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 90111573   170 TLEFTIEEVNADRNVS----NNAKNRQIVLNLYEKGIFDIKDAINQVADRLNISKHTVYLYIR 228
Cdd:pfam13309   1 LLDSIIDEVLADVGKPparlTKEEKREIVRALDEKGAFLLKGAVEKVAKRLGVSRATVYNYLR 63
HTH_23 pfam13384
Homeodomain-like domain;
185-237 3.03e-03

Homeodomain-like domain;


Pssm-ID: 433164 [Multi-domain]  Cd Length: 50  Bit Score: 34.94  E-value: 3.03e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 90111573   185 SNNAKNRQIVLNLYEKGIfdikdAINQVADRLNISKHTVYLYIRQFKSGDFQG 237
Cdd:pfam13384   1 SARERRRARALLLLAEGL-----SVKEIAELLGVSRRTVYRWLKRYNEEGLEG 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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