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Conserved domains on  [gi|16131288|ref|NP_417871|]
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pimeloyl-acyl carrier protein methyl ester esterase [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

pimeloyl-ACP methyl ester esterase BioH( domain architecture ID 10793379)

pimeloyl-ACP methyl ester esterase BioH removes the methyl group introduced by BioC when the pimeloyl moiety is complete

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10349 PRK10349
pimeloyl-ACP methyl ester esterase BioH;
1-256 0e+00

pimeloyl-ACP methyl ester esterase BioH;


:

Pssm-ID: 137836 [Multi-domain]  Cd Length: 256  Bit Score: 544.23  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288    1 MNNIWWQTKGQGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRGFGALSLADMAEAVLQQAPDKAIWLG 80
Cdd:PRK10349   1 MNNIWWQTKGQGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRGFGALSLADMAEAVLQQAPDKAIWLG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288   81 WSLGGLVASQIALTHPERVQALVTVASSPCFSARDEWPGIKPDVLAGFQQQLSDDFQRTVERFLALQTMGTETARQDARA 160
Cdd:PRK10349  81 WSLGGLVASQIALTHPERVQALVTVASSPCFSARDEWPGIKPDVLAGFQQQLSDDFQRTVERFLALQTMGTETARQDARA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288  161 LKKTVLALPMPEVDVLNGGLEILKTVDLRQPLQNVSMPFLRLYGYLDGLVPRKVVPMLDKLWPHSESYIFAKAAHAPFIS 240
Cdd:PRK10349 161 LKKTVLALPMPEVDVLNGGLEILKTVDLRQPLQNVSMPFLRLYGYLDGLVPRKVVPMLDKLWPHSESYIFAKAAHAPFIS 240

                        250
                 ....*....|....*.
gi 16131288  241 HPAEFCHLLVALKQRV 256
Cdd:PRK10349 241 HPAEFCHLLVALKQRV 256
 
Name Accession Description Interval E-value
PRK10349 PRK10349
pimeloyl-ACP methyl ester esterase BioH;
1-256 0e+00

pimeloyl-ACP methyl ester esterase BioH;


Pssm-ID: 137836 [Multi-domain]  Cd Length: 256  Bit Score: 544.23  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288    1 MNNIWWQTKGQGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRGFGALSLADMAEAVLQQAPDKAIWLG 80
Cdd:PRK10349   1 MNNIWWQTKGQGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRGFGALSLADMAEAVLQQAPDKAIWLG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288   81 WSLGGLVASQIALTHPERVQALVTVASSPCFSARDEWPGIKPDVLAGFQQQLSDDFQRTVERFLALQTMGTETARQDARA 160
Cdd:PRK10349  81 WSLGGLVASQIALTHPERVQALVTVASSPCFSARDEWPGIKPDVLAGFQQQLSDDFQRTVERFLALQTMGTETARQDARA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288  161 LKKTVLALPMPEVDVLNGGLEILKTVDLRQPLQNVSMPFLRLYGYLDGLVPRKVVPMLDKLWPHSESYIFAKAAHAPFIS 240
Cdd:PRK10349 161 LKKTVLALPMPEVDVLNGGLEILKTVDLRQPLQNVSMPFLRLYGYLDGLVPRKVVPMLDKLWPHSESYIFAKAAHAPFIS 240

                        250
                 ....*....|....*.
gi 16131288  241 HPAEFCHLLVALKQRV 256
Cdd:PRK10349 241 HPAEFCHLLVALKQRV 256
bioH TIGR01738
pimelyl-[acyl-carrier protein] methyl ester esterase; This CoA-binding enzyme is required for ...
 10-253 4.75e-148

pimelyl-[acyl-carrier protein] methyl ester esterase; This CoA-binding enzyme is required for the production of pimeloyl-coenzyme A, the substrate of the BioF protein early in the biosynthesis of biotin. Its exact function is unknown, but is proposed in ref 2. This enzyme belongs to the alpha/beta hydrolase fold family (pfam00561). Members of this family are restricted to the Proteobacteria. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273783 [Multi-domain]  Cd Length: 245  Bit Score: 413.44  E-value: 4.75e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288    10 GQGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRGFGALSLADMAEAVLQQAPDKAIWLGWSLGGLVAS 89
Cdd:TIGR01738   1 GQGNVHLVLIHGWGMNAEVFRCLDEELSAHFTLHLVDLPGHGRSRGFGPLSLADMAEAIAAQAPDPAIWLGWSLGGLVAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288    90 QIALTHPERVQALVTVASSPCFSARDEWP-GIKPDVLAGFQQQLSDDFQRTVERFLALQTMGTETARQDARALKKTVLAL 168
Cdd:TIGR01738  81 HIAATHPDRVRALVTVASSPCFSAREDWPeGIKPDVLTGFQQQLSDDYQRTIERFLALQTLGTPTARQDARALKQTLLAR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288   169 PMPEVDVLNGGLEILKTVDLRQPLQNVSMPFLRLYGYLDGLVPRKVVPMLDKLWPHSESYIFAKAAHAPFISHPAEFCHL 248
Cdd:TIGR01738 161 PTPNVQVLQAGLEILATVDLRQPLQNISVPFLRLYGYLDGLVPAKVVPMLDKLAPHSELYIFAKAAHAPFLSHAEAFCAL 240


                  ....*
gi 16131288   249 LVALK 253
Cdd:TIGR01738 241 LVAFK 245
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 15-242 1.33e-40

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 139.95  E-value: 1.33e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288    15 HLVLLHGWGLNAEVWRCIDEELS-SHFTLHLVDLPGFGRSR------GFGALSLADMAEAVLQQAP-DKAIWLGWSLGGL 86
Cdd:pfam00561   2 PVLLLHGLPGSSDLWRKLAPALArDGFRVIALDLRGFGKSSrpkaqdDYRTDDLAEDLEYILEALGlEKVNLVGHSMGGL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288    87 VASQIALTHPERVQALVTVAS-SPCFSARDEWPGIKPDVLAGFQQQLSDDFQRTVERFLALQTMGTETARQDARALKKTV 165
Cdd:pfam00561  82 IALAYAAKYPDRVKALVLLGAlDPPHELDEADRFILALFPGFFDGFVADFAPNPLGRLVAKLLALLLLRLRLLKALPLLN 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288   166 L-------ALPMPEVDVLNGGLEILKTVDLRQPLQNVSMPFLRLYGYLDGLVPRKVVPMLDKLWPHSESYIFAKAAHAPF 238
Cdd:pfam00561 162 KrfpsgdyALAKSLVTGALLFIETWSTELRAKFLGRLDEPTLIIWGDQDPLVPPQALEKLAQLFPNARLVVIPDAGHFAF 241


                  ....
gi 16131288   239 ISHP 242
Cdd:pfam00561 242 LEGP 245
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 3-251 4.31e-36

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 127.42  E-value: 4.31e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288   3 NIWWQTKGQGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRGF-GALSLADMAEAVL----QQAPDKAI 77
Cdd:COG0596  13 RLHYREAGPDGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPaGGYTLDDLADDLAalldALGLERVV 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288  78 WLGWSLGGLVASQIALTHPERVQALVTVAsspcfsardewpgikpDVLAGFQQQLSDDFQRtverflalqtmgtetarqd 157
Cdd:COG0596  93 LVGHSMGGMVALELAARHPERVAGLVLVD----------------EVLAALAEPLRRPGLA------------------- 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288 158 aralkktvlalpmpeVDVLNGGLEILKTVDLRQPLQNVSMPFLRLYGYLDGLVPRKVVPMLDKLWPHSESYIFAKAAHAP 237
Cdd:COG0596 138 ---------------PEALAALLRALARTDLRERLARITVPTLVIWGEKDPIVPPALARRLAELLPNAELVVLPGAGHFP 202

                       250
                ....*....|....
gi 16131288 238 FISHPAEFCHLLVA 251
Cdd:COG0596 203 PLEQPEAFAAALRD 216
 
Name Accession Description Interval E-value
PRK10349 PRK10349
pimeloyl-ACP methyl ester esterase BioH;
1-256 0e+00

pimeloyl-ACP methyl ester esterase BioH;


Pssm-ID: 137836 [Multi-domain]  Cd Length: 256  Bit Score: 544.23  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288    1 MNNIWWQTKGQGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRGFGALSLADMAEAVLQQAPDKAIWLG 80
Cdd:PRK10349   1 MNNIWWQTKGQGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRGFGALSLADMAEAVLQQAPDKAIWLG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288   81 WSLGGLVASQIALTHPERVQALVTVASSPCFSARDEWPGIKPDVLAGFQQQLSDDFQRTVERFLALQTMGTETARQDARA 160
Cdd:PRK10349  81 WSLGGLVASQIALTHPERVQALVTVASSPCFSARDEWPGIKPDVLAGFQQQLSDDFQRTVERFLALQTMGTETARQDARA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288  161 LKKTVLALPMPEVDVLNGGLEILKTVDLRQPLQNVSMPFLRLYGYLDGLVPRKVVPMLDKLWPHSESYIFAKAAHAPFIS 240
Cdd:PRK10349 161 LKKTVLALPMPEVDVLNGGLEILKTVDLRQPLQNVSMPFLRLYGYLDGLVPRKVVPMLDKLWPHSESYIFAKAAHAPFIS 240

                        250
                 ....*....|....*.
gi 16131288  241 HPAEFCHLLVALKQRV 256
Cdd:PRK10349 241 HPAEFCHLLVALKQRV 256
bioH TIGR01738
pimelyl-[acyl-carrier protein] methyl ester esterase; This CoA-binding enzyme is required for ...
 10-253 4.75e-148

pimelyl-[acyl-carrier protein] methyl ester esterase; This CoA-binding enzyme is required for the production of pimeloyl-coenzyme A, the substrate of the BioF protein early in the biosynthesis of biotin. Its exact function is unknown, but is proposed in ref 2. This enzyme belongs to the alpha/beta hydrolase fold family (pfam00561). Members of this family are restricted to the Proteobacteria. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273783 [Multi-domain]  Cd Length: 245  Bit Score: 413.44  E-value: 4.75e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288    10 GQGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRGFGALSLADMAEAVLQQAPDKAIWLGWSLGGLVAS 89
Cdd:TIGR01738   1 GQGNVHLVLIHGWGMNAEVFRCLDEELSAHFTLHLVDLPGHGRSRGFGPLSLADMAEAIAAQAPDPAIWLGWSLGGLVAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288    90 QIALTHPERVQALVTVASSPCFSARDEWP-GIKPDVLAGFQQQLSDDFQRTVERFLALQTMGTETARQDARALKKTVLAL 168
Cdd:TIGR01738  81 HIAATHPDRVRALVTVASSPCFSAREDWPeGIKPDVLTGFQQQLSDDYQRTIERFLALQTLGTPTARQDARALKQTLLAR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288   169 PMPEVDVLNGGLEILKTVDLRQPLQNVSMPFLRLYGYLDGLVPRKVVPMLDKLWPHSESYIFAKAAHAPFISHPAEFCHL 248
Cdd:TIGR01738 161 PTPNVQVLQAGLEILATVDLRQPLQNISVPFLRLYGYLDGLVPAKVVPMLDKLAPHSELYIFAKAAHAPFLSHAEAFCAL 240


                  ....*
gi 16131288   249 LVALK 253
Cdd:TIGR01738 241 LVAFK 245
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 15-242 1.33e-40

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 139.95  E-value: 1.33e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288    15 HLVLLHGWGLNAEVWRCIDEELS-SHFTLHLVDLPGFGRSR------GFGALSLADMAEAVLQQAP-DKAIWLGWSLGGL 86
Cdd:pfam00561   2 PVLLLHGLPGSSDLWRKLAPALArDGFRVIALDLRGFGKSSrpkaqdDYRTDDLAEDLEYILEALGlEKVNLVGHSMGGL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288    87 VASQIALTHPERVQALVTVAS-SPCFSARDEWPGIKPDVLAGFQQQLSDDFQRTVERFLALQTMGTETARQDARALKKTV 165
Cdd:pfam00561  82 IALAYAAKYPDRVKALVLLGAlDPPHELDEADRFILALFPGFFDGFVADFAPNPLGRLVAKLLALLLLRLRLLKALPLLN 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288   166 L-------ALPMPEVDVLNGGLEILKTVDLRQPLQNVSMPFLRLYGYLDGLVPRKVVPMLDKLWPHSESYIFAKAAHAPF 238
Cdd:pfam00561 162 KrfpsgdyALAKSLVTGALLFIETWSTELRAKFLGRLDEPTLIIWGDQDPLVPPQALEKLAQLFPNARLVVIPDAGHFAF 241


                  ....
gi 16131288   239 ISHP 242
Cdd:pfam00561 242 LEGP 245
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 3-251 4.31e-36

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 127.42  E-value: 4.31e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288   3 NIWWQTKGQGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRGF-GALSLADMAEAVL----QQAPDKAI 77
Cdd:COG0596  13 RLHYREAGPDGPPVVLLHGLPGSSYEWRPLIPALAAGYRVIAPDLRGHGRSDKPaGGYTLDDLADDLAalldALGLERVV 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288  78 WLGWSLGGLVASQIALTHPERVQALVTVAsspcfsardewpgikpDVLAGFQQQLSDDFQRtverflalqtmgtetarqd 157
Cdd:COG0596  93 LVGHSMGGMVALELAARHPERVAGLVLVD----------------EVLAALAEPLRRPGLA------------------- 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288 158 aralkktvlalpmpeVDVLNGGLEILKTVDLRQPLQNVSMPFLRLYGYLDGLVPRKVVPMLDKLWPHSESYIFAKAAHAP 237
Cdd:COG0596 138 ---------------PEALAALLRALARTDLRERLARITVPTLVIWGEKDPIVPPALARRLAELLPNAELVVLPGAGHFP 202

                       250
                ....*....|....
gi 16131288 238 FISHPAEFCHLLVA 251
Cdd:COG0596 203 PLEQPEAFAAALRD 216
menH_SHCHC TIGR03695
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; This protein catalyzes the ...
 16-252 1.44e-15

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; This protein catalyzes the formation of SHCHC, or (1 R,6 R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate, by elmination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Note that SHCHC synthase activity previously was attributed to MenD, which in fact is SEPHCHC synthase. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]


Pssm-ID: 274729 [Multi-domain]  Cd Length: 252  Bit Score: 73.79  E-value: 1.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288    16 LVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRGFGALSLADMAEAV-------LQQAPDKAIWL-GWSLGGLV 87
Cdd:TIGR03695   5 LVFLHGFLGSGADWQALIEALGPHFRCLAIDLPGHGSSQSPSDIERYDFEEAAqlllatlLDQLGIEPFFLvGYSMGGRI 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288    88 ASQIALTHPERVQALVTVASSPCFSARDE----------WP------GIkPDVLAGFQQQ--------LSDDFQRTVERf 143
Cdd:TIGR03695  85 ALYYALQYPERVQGLILESGSPGLQTEEEraarrqndeqLAqrfeqeGL-EAFLDDWYQQplfasqknLPPEQRQALRA- 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288   144 lalqtmgtETARQDARALKKTVLAL---PMPevdvlnggleilktvDLRQPLQNVSMPFLRLYGYLDGlvprKVVPM--- 217
Cdd:TIGR03695 163 --------ERLANNPEGLAKMLRATglgKQP---------------SLWPKLQALKIPVLYLCGERDE----KFVQIake 215

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 16131288   218 LDKLWPHSESYIFAKAAHAPFISHPAEFCHLLVAL 252
Cdd:TIGR03695 216 MQKLIPNLTLHIIPNAGHNIHLENPEAFAKILLAF 250
PRK14875 PRK14875
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional
 16-251 8.57e-15

acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional


Pssm-ID: 184875 [Multi-domain]  Cd Length: 371  Bit Score: 73.05  E-value: 8.57e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288   16 LVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRS-RGFGALSLADMAEAVL----QQAPDKAIWLGWSLGGLVASQ 90
Cdd:PRK14875 134 VVLIHGFGGDLNNWLFNHAALAAGRPVIALDLPGHGASsKAVGAGSLDELAAAVLafldALGIERAHLVGHSMGGAVALR 213

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288   91 IALTHPERVQALVTVASSPCfsardeWPGIKPDVLAGF-------------------QQQLSDDFQRTVERFLALqtmgt 151
Cdd:PRK14875 214 LAARAPQRVASLTLIAPAGL------GPEINGDYIDGFvaaesrrelkpvlellfadPALVTRQMVEDLLKYKRL----- 282

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288  152 ETARQDARALKKTVLAlpmpevdvlnGGLEilkTVDLRQPLQNVSMPFLRLYGYLDGLVPrkvvpmldklWPHSES---- 227
Cdd:PRK14875 283 DGVDDALRALADALFA----------GGRQ---RVDLRDRLASLAIPVLVIWGEQDRIIP----------AAHAQGlpdg 339

                        250       260
                 ....*....|....*....|....*..
gi 16131288  228 ---YIFAKAAHAPFISHPAEFCHLLVA 251
Cdd:PRK14875 340 vavHVLPGAGHMPQMEAAADVNRLLAE 366
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
5-129 6.26e-14

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 68.88  E-value: 6.26e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288   5 WWQTKGQGNVHLVLLHGWGLNAEVWRCIDEELSSH-FTLHLVDLPGFGRSRGFGALS---------LADMAEAVLQQAPD 74
Cdd:COG2267  20 RWRPAGSPRGTVVLVHGLGEHSGRYAELAEALAAAgYAVLAFDLRGHGRSDGPRGHVdsfddyvddLRAALDALRARPGL 99

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 16131288  75 KAIWLGWSLGGLVASQIALTHPERVQALvtVASSPCFsARDEWPGIKPDVLAGFQ 129
Cdd:COG2267 100 PVVLLGHSMGGLIALLYAARYPDRVAGL--VLLAPAY-RADPLLGPSARWLRALR 151
PLN02578 PLN02578
hydrolase
 3-245 1.41e-11

hydrolase


Pssm-ID: 215315 [Multi-domain]  Cd Length: 354  Bit Score: 63.32  E-value: 1.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288    3 NIW-WQT-------KGQGnVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRgfGAL----------SLADM 64
Cdd:PLN02578  69 NFWtWRGhkihyvvQGEG-LPIVLIHGFGASAFHWRYNIPELAKKYKVYALDLLGFGWSD--KALieydamvwrdQVADF 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288   65 AEAVLQqapDKAIWLGWSLGGLVASQIALTHPERVQALVTVASSPCFSA----RDEWPGIKPDVLAGFQ-QQLSDDFQRT 139
Cdd:PLN02578 146 VKEVVK---EPAVLVGNSLGGFTALSTAVGYPELVAGVALLNSAGQFGSesreKEEAIVVEETVLTRFVvKPLKEWFQRV 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288  140 VERFLALQtmgtetARQDAR---ALKKT-----------VLALPMPEVDVlNGGlEI---LKTVDLRQP--------LQN 194
Cdd:PLN02578 223 VLGFLFWQ------AKQPSRiesVLKSVykdksnvddylVESITEPAADP-NAG-EVyyrLMSRFLFNQsrytldslLSK 294

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 16131288  195 VSMPFLRLYGYLDGLVPRKVVPMLDKLWPHSeSYIFAKAAHAPFISHPAEF 245
Cdd:PLN02578 295 LSCPLLLLWGDLDPWVGPAKAEKIKAFYPDT-TLVNLQAGHCPHDEVPEQV 344
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 16-107 6.35e-09

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 52.14  E-value: 6.35e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288  16 LVLLHGWGLNAEVWRCIDEELSSH-FTLHLVDLPGFGRSRGFGALSLADMAEAVLQQAPDKAIWL-GWSLGGLVAsQIAL 93
Cdd:COG1075   8 VVLVHGLGGSAASWAPLAPRLRAAgYPVYALNYPSTNGSIEDSAEQLAAFVDAVLAATGAEKVDLvGHSMGGLVA-RYYL 86

                        90
                ....*....|....*..
gi 16131288  94 TH---PERVQALVTVAS 107
Cdd:COG1075  87 KRlggAAKVARVVTLGT 103
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 16-122 5.55e-08

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 51.71  E-value: 5.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288    16 LVLLHGWGLNAEVWRcidEELSSHFTLHLVDLPGFGRSRG--FGALSLADMAEAVLQ-QAPDKAIWLGWSLGGLVASQiA 92
Cdd:pfam12697   1 VVLVHGAGLSAAPLA---ALLAAGVAVLAPDLPGHGSSSPppLDLADLADLAALLDElGAARPVVLVGHSLGGAVALA-A 76

                          90       100       110
                  ....*....|....*....|....*....|
gi 16131288    93 LTHPERVQALVTVASSPCFSARDEWPGIKP 122
Cdd:pfam12697  77 AAAALVVGVLVAPLAAPPGLLAALLALLAR 106
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
12-235 1.57e-07

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 50.71  E-value: 1.57e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288  12 GNVHLVLLHGWGLNAEVWRCIDEELSSH-FTLHLVDLPGFGRSRG-FGALSLADMAEAV------LQQAPDKAIWLGWSL 83
Cdd:COG1647  14 GRKGVLLLHGFTGSPAEMRPLAEALAKAgYTVYAPRLPGHGTSPEdLLKTTWEDWLEDVeeayeiLKAGYDKVIVIGLSM 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288  84 GGLVASQIALTHPErVQALVTVasSPCFSARDEWPGIKPdvlagfqqqlsddFQRTVERFLALQTMGTETARQDARALKK 163
Cdd:COG1647  94 GGLLALLLAARYPD-VAGLVLL--SPALKIDDPSAPLLP-------------LLKYLARSLRGIGSDIEDPEVAEYAYDR 157

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 16131288 164 TvlalPMPEVDVLNGGLEilktvDLRQPLQNVSMPFLRLYGYLDGLVPRKVVPMLDKLWPHSES--YIFAKAAH 235
Cdd:COG1647 158 T----PLRALAELQRLIR-----EVRRDLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPDKelVWLEDSGH 222
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
16-138 2.48e-07

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 50.02  E-value: 2.48e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288  16 LVLLHGWGLNAEV-WRCIDEELSSH-FTLHLVDLPGFGRSRG-FGALSLADMAEAV--LQQAP----DKAIWLGWSLGGL 86
Cdd:COG1506  26 VVYVHGGPGSRDDsFLPLAQALASRgYAVLAPDYRGYGESAGdWGGDEVDDVLAAIdyLAARPyvdpDRIGIYGHSYGGY 105

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 16131288  87 VASQIALTHPERVQALVTVASSPCFSARDEWPGIKPDVLAGFQQQLSDDFQR 138
Cdd:COG1506 106 MALLAAARHPDRFKAAVALAGVSDLRSYYGTTREYTERLMGGPWEDPEAYAA 157
PRK11126 PRK11126
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; Provisional
 16-103 6.01e-07

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; Provisional


Pssm-ID: 236855 [Multi-domain]  Cd Length: 242  Bit Score: 49.07  E-value: 6.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288   16 LVLLHGWGLNAEVWRCIDEELSSHFTLhLVDLPGFGRSRGFGALSLADMAE---AVLQQAPDKAIWL-GWSLGGLVASQI 91
Cdd:PRK11126   5 LVFLHGLLGSGQDWQPVGEALPDYPRL-YIDLPGHGGSAAISVDGFADVSRllsQTLQSYNILPYWLvGYSLGGRIAMYY 83

                         90
                 ....*....|...
gi 16131288   92 AL-THPERVQALV 103
Cdd:PRK11126  84 ACqGLAGGLCGLI 96
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 16-212 1.54e-06

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 47.98  E-value: 1.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288    16 LVLLHGwgLNAEVWRCID--EELSSH-FTLHLVDLPGFGRSRG-------FGAL--SLADMAEAVLQQAPD-KAIWLGWS 82
Cdd:pfam12146   7 VVLVHG--LGEHSGRYAHlaDALAAQgFAVYAYDHRGHGRSDGkrghvpsFDDYvdDLDTFVDKIREEHPGlPLFLLGHS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288    83 LGGLVASQIALTHPERVQALvtVASSPCFsardewpGIKPDVLAGFQQQLSDDFQRTVERFLALQTMGTETARQDARALK 162
Cdd:pfam12146  85 MGGLIAALYALRYPDKVDGL--ILSAPAL-------KIKPYLAPPILKLLAKLLGKLFPRLRVPNNLLPDSLSRDPEVVA 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 16131288   163 KTV---LALPMPEVDVLNGGLEILKtvDLRQPLQNVSMPFLRLYGYLDGLVPR 212
Cdd:pfam12146 156 AYAadpLVHGGISARTLYELLDAGE--RLLRRAAAITVPLLLLHGGADRVVDP 206
Thioesterase pfam00975
Thioesterase domain; Peptide synthetases are involved in the non-ribosomal synthesis of ...
 15-191 1.89e-06

Thioesterase domain; Peptide synthetases are involved in the non-ribosomal synthesis of peptide antibiotics. Next to the operons encoding these enzymes, in almost all cases, are genes that encode proteins that have similarity to the type II fatty acid thioesterases of vertebrates. There are also modules within the peptide synthetases that also share this similarity. With respect to antibiotic production, thioesterases are required for the addition of the last amino acid to the peptide antibiotic, thereby forming a cyclic antibiotic. Thioesterases (non-integrated) have molecular masses of 25-29 kDa.


Pssm-ID: 395776 [Multi-domain]  Cd Length: 223  Bit Score: 47.38  E-value: 1.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288    15 HLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRGF--GALSLADM-AEAVLQQAPDKAIWL-GWSLGGLVASQ 90
Cdd:pfam00975   2 PLFCFPPAGGSASSFRSLARRLPPPAEVLAVQYPGRGRGEPPlnSIEALADEyAEALRQIQPEGPYALfGHSMGGMLAFE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288    91 IALTHPER---VQALVTVASSPCFSARDeWPGIKPDvLAGFQQQLsDDFQRTVERFLALQ---TMGTETARQDARALKKT 164
Cdd:pfam00975  82 VARRLERQgeaVRSLFLSDASAPHTVRY-EASRAPD-DDEVVAEF-TDEGGTPEELLEDEellSMLLPALRADYRALESY 158

                         170       180
                  ....*....|....*....|....*...
gi 16131288   165 VL-ALPMPEVDVLNGGLEILKTVDLRQP 191
Cdd:pfam00975 159 SCpPLDAQSATLFYGSDDPLHDADDLAE 186
PLN02894 PLN02894
hydrolase, alpha/beta fold family protein
 16-118 3.61e-06

hydrolase, alpha/beta fold family protein


Pssm-ID: 215484 [Multi-domain]  Cd Length: 402  Bit Score: 47.60  E-value: 3.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288   16 LVLLHGWGLNAEVW-RCIDEeLSSHFTLHLVDLPGFGRSR--GFGALS--------LADMAEAVLQQAPDKAIWLGWSLG 84
Cdd:PLN02894 108 LVMVHGYGASQGFFfRNFDA-LASRFRVIAIDQLGWGGSSrpDFTCKSteeteawfIDSFEEWRKAKNLSNFILLGHSFG 186

                         90       100       110
                 ....*....|....*....|....*....|....
gi 16131288   85 GLVASQIALTHPERVQALVTVASSPCFSARDEWP 118
Cdd:PLN02894 187 GYVAAKYALKHPEHVQHLILVGPAGFSSESDDKS 220
PLN02824 PLN02824
hydrolase, alpha/beta fold family protein
 3-103 8.83e-06

hydrolase, alpha/beta fold family protein


Pssm-ID: 178419 [Multi-domain]  Cd Length: 294  Bit Score: 45.88  E-value: 8.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288    3 NIWWQTKGQGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRS-----RGFGALS----------LADMAEA 67
Cdd:PLN02824  19 NIRYQRAGTSGPALVLVHGFGGNADHWRKNTPVLAKSHRVYAIDLLGYGYSdkpnpRSAPPNSfytfetwgeqLNDFCSD 98

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 16131288   68 VLQqapDKAIWLGWSLGGLVASQIALTHPERVQALV 103
Cdd:PLN02824  99 VVG---DPAFVICNSVGGVVGLQAAVDAPELVRGVM 131
PLN02980 PLN02980
2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate ...
 9-109 3.24e-05

2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate binding


Pssm-ID: 215530 [Multi-domain]  Cd Length: 1655  Bit Score: 44.85  E-value: 3.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288     9 KGQGNVhLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRGFG---------ALSLADMAEAVL----QQAPDK 75
Cdd:PLN02980 1368 NAEGSV-VLFLHGFLGTGEDWIPIMKAISGSARCISIDLPGHGGSKIQNhaketqtepTLSVELVADLLYklieHITPGK 1446

                          90       100       110
                  ....*....|....*....|....*....|....
gi 16131288    76 AIWLGWSLGGLVASQIALTHPERVQALVTVASSP 109
Cdd:PLN02980 1447 VTLVGYSMGARIALYMALRFSDKIEGAVIISGSP 1480
metX PRK00175
homoserine O-acetyltransferase; Provisional
 79-113 1.04e-03

homoserine O-acetyltransferase; Provisional


Pssm-ID: 234678 [Multi-domain]  Cd Length: 379  Bit Score: 39.79  E-value: 1.04e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 16131288   79 LGWSLGGLVASQIALTHPERVQALVTVASSPCFSA 113
Cdd:PRK00175 152 VGGSMGGMQALEWAIDYPDRVRSALVIASSARLSA 186
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 16-106 1.17e-03

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 39.13  E-value: 1.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288  16 LVLLHGWGLNAEVWRcideELSSHF------TLhLVDLPGFGRS----RGFGALSLADMAEAV--LQQ----APDKAIWL 79
Cdd:COG1073  40 VVVAHGNGGVKEQRA----LYAQRLaelgfnVL-AFDYRGYGESegepREEGSPERRDARAAVdyLRTlpgvDPERIGLL 114

                        90       100
                ....*....|....*....|....*..
gi 16131288  80 GWSLGGLVASQIALTHPeRVQALVTVA 106
Cdd:COG1073 115 GISLGGGYALNAAATDP-RVKAVILDS 140
entF PRK10252
enterobactin non-ribosomal peptide synthetase EntF;
60-147 1.17e-03

enterobactin non-ribosomal peptide synthetase EntF;


Pssm-ID: 236668 [Multi-domain]  Cd Length: 1296  Bit Score: 40.03  E-value: 1.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288    60 SLADMAEA----VLQQAPDKAIWL-GWSLGGLVASQIALTHPER---VQALVTVASSP--CFSARDEWP-GIKPDVLAgf 128
Cdd:PRK10252 1114 SLDEVCEAhlatLLEQQPHGPYHLlGYSLGGTLAQGIAARLRARgeeVAFLGLLDTWPpeTQNWREKEAnGLDPEVLA-- 1191

                          90
                  ....*....|....*....
gi 16131288   129 qqqlsdDFQRTVERFLALQ 147
Cdd:PRK10252 1192 ------EIDREREAFLAAQ 1204
PRK05855 PRK05855
SDR family oxidoreductase;
16-110 1.22e-03

SDR family oxidoreductase;


Pssm-ID: 235628 [Multi-domain]  Cd Length: 582  Bit Score: 39.96  E-value: 1.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288   16 LVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRS---RGFGALSLADMAE---AVLQQ-APDKAIWL---GWslgG 85
Cdd:PRK05855  28 VVLVHGYPDNHEVWDGVAPLLADRFRVVAYDVRGAGRSsapKRTAAYTLARLADdfaAVIDAvSPDRPVHLlahDW---G 104

                         90       100
                 ....*....|....*....|....*...
gi 16131288   86 LVASQIALTHPE---RVQALVTVaSSPC 110
Cdd:PRK05855 105 SIQGWEAVTRPRaagRIASFTSV-SGPS 131
MET2 COG2021
Homoserine O-acetyltransferase [Amino acid transport and metabolism]; Homoserine ...
 79-113 1.92e-03

Homoserine O-acetyltransferase [Amino acid transport and metabolism]; Homoserine O-acetyltransferase is part of the Pathway/BioSystem: Methionine biosynthesis


Pssm-ID: 441624 [Multi-domain]  Cd Length: 355  Bit Score: 38.92  E-value: 1.92e-03
                        10        20        30
                ....*....|....*....|....*....|....*
gi 16131288  79 LGWSLGGLVASQIALTHPERVQALVTVASSPCFSA 113
Cdd:COG2021 133 IGGSMGGMQALEWAVSYPDRVRRAIVIATAARLSA 167
PRK10673 PRK10673
esterase;
3-109 2.17e-03

esterase;


Pssm-ID: 182637 [Multi-domain]  Cd Length: 255  Bit Score: 38.56  E-value: 2.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288    3 NIWWQT--KGQGNVHLVLLHGWGLNAEVWRCIDEELSSHFTLHLVDLPGFGRSRGFGALSLADMAEAVLQ----QAPDKA 76
Cdd:PRK10673   4 NIRAQTaqNPHNNSPIVLVHGLFGSLDNLGVLARDLVNDHDIIQVDMRNHGLSPRDPVMNYPAMAQDLLDtldaLQIEKA 83

                         90       100       110
                 ....*....|....*....|....*....|...
gi 16131288   77 IWLGWSLGGLVASQIALTHPERVQALVTVASSP 109
Cdd:PRK10673  84 TFIGHSMGGKAVMALTALAPDRIDKLVAIDIAP 116
Fes COG2382
Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];
16-179 7.10e-03

Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];


Pssm-ID: 441948 [Multi-domain]  Cd Length: 314  Bit Score: 37.14  E-value: 7.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288  16 LVLLHGWGLNAEVW-------RCIDEELSSH-------FTLHLVDLPGFGRSRGFGALSLADMAEAVLQQA-------PD 74
Cdd:COG2382 115 LYLLDGGGGDEQDWfdqgrlpTILDNLIAAGkippmivVMPDGGDGGDRGTEGPGNDAFERFLAEELIPFVeknyrvsAD 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131288  75 KAIW--LGWSLGGLVASQIALTHPERVQALVTVASSPcfsardeWPGIKPDVLAGFQQQLSDDFQRTVERFlaLQTMGT- 151
Cdd:COG2382 195 PEHRaiAGLSMGGLAALYAALRHPDLFGYVGSFSGSF-------WWPPGDADRGGWAELLAAGAPKKPLRF--YLDVGTe 265

                       170       180
                ....*....|....*....|....*....
gi 16131288 152 ETARQDARALKKTVLALPMP-EVDVLNGG 179
Cdd:COG2382 266 DDLLEANRALAAALKAKGYDvEYREFPGG 294
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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