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Conserved domains on  [gi|162135912|ref|NP_417966|]
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periplasmic acid stress chaperone HdeB [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

HdeA family protein( domain architecture ID 10013834)

HdeA family protein similar to acid-activated periplasmic chaperone HdeA, an acid-resistant chaperone that functions at low pH when it undergoes a transition from a well-folded dimer to an unfolded monomer, exposing hydrophobic surfaces that allows binding to a broad range of client proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
hdeB PRK11566
acid-activated periplasmic chaperone HdeB;
7-108 3.80e-58

acid-activated periplasmic chaperone HdeB;


:

Pssm-ID: 183204  Cd Length: 102  Bit Score: 174.22  E-value: 3.80e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162135912   7 RKAFIFMGAVAALSLVNAQSALAANESAKDMTCQEFIDLNPKAMTPVAWWMLHEETVYKGGDTVTLNETDLTQIPKVIEY 86
Cdd:PRK11566   1 RKAFIFMAAVTALSLVNAQSATATNTTPKDMTCQEFIDLNPKSMTPVAFWVLNEDTDYKGGDYVDLNETDTTQVPKVIEY 80

                         90       100
                 ....*....|....*....|..
gi 162135912  87 CKKNPQKNLYTFKNQASNDLPN 108
Cdd:PRK11566  81 CKKNPQKKLSTIKNQIKNDLPK 102
 
Name Accession Description Interval E-value
hdeB PRK11566
acid-activated periplasmic chaperone HdeB;
7-108 3.80e-58

acid-activated periplasmic chaperone HdeB;


Pssm-ID: 183204  Cd Length: 102  Bit Score: 174.22  E-value: 3.80e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162135912   7 RKAFIFMGAVAALSLVNAQSALAANESAKDMTCQEFIDLNPKAMTPVAWWMLHEETVYKGGDTVTLNETDLTQIPKVIEY 86
Cdd:PRK11566   1 RKAFIFMAAVTALSLVNAQSATATNTTPKDMTCQEFIDLNPKSMTPVAFWVLNEDTDYKGGDYVDLNETDTTQVPKVIEY 80

                         90       100
                 ....*....|....*....|..
gi 162135912  87 CKKNPQKNLYTFKNQASNDLPN 108
Cdd:PRK11566  81 CKKNPQKKLSTIKNQIKNDLPK 102
HdeA pfam06411
HdeA/HdeB family; HdeA (hns-dependent expression protein A) is a single domain alpha-helical ...
 13-97 1.73e-27

HdeA/HdeB family; HdeA (hns-dependent expression protein A) is a single domain alpha-helical protein localized in the periplasmic space. HdeA is involved in acid resistance essential for infectivity of enteric bacterial pathogens. Functional studies demonstrate that HdeA is activated by a dimer-to-monomer transition at acidic pH, leading to suppression of aggregation by acid-denatured proteins. The gene encoding HdeA was initially identified as part of an operon regulated by the nucleoid protein H-NS. This family also contains HdeB.


Pssm-ID: 428923  Cd Length: 92  Bit Score: 96.30  E-value: 1.73e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162135912   13 MGAVAALSL-VNAQSALAANESAK------DMTCQEFIDLNPKAMTPVAWWMLHEETVYKGGDTVTLNETDLTQIPKVIE 85
Cdd:pfam06411   1 LLALAAAALaAFSSSAMAQTASATpkkdlsKMTCEDFLDLDEEFKPPVIYWAEGYNSKGKPGDAVIDIEGIEKVTPKVVD 80

                          90
                  ....*....|..
gi 162135912   86 YCKKNPQKNLYT 97
Cdd:pfam06411  81 YCKKNPKASLMD 92
 
Name Accession Description Interval E-value
hdeB PRK11566
acid-activated periplasmic chaperone HdeB;
7-108 3.80e-58

acid-activated periplasmic chaperone HdeB;


Pssm-ID: 183204  Cd Length: 102  Bit Score: 174.22  E-value: 3.80e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162135912   7 RKAFIFMGAVAALSLVNAQSALAANESAKDMTCQEFIDLNPKAMTPVAWWMLHEETVYKGGDTVTLNETDLTQIPKVIEY 86
Cdd:PRK11566   1 RKAFIFMAAVTALSLVNAQSATATNTTPKDMTCQEFIDLNPKSMTPVAFWVLNEDTDYKGGDYVDLNETDTTQVPKVIEY 80

                         90       100
                 ....*....|....*....|..
gi 162135912  87 CKKNPQKNLYTFKNQASNDLPN 108
Cdd:PRK11566  81 CKKNPQKKLSTIKNQIKNDLPK 102
HdeA pfam06411
HdeA/HdeB family; HdeA (hns-dependent expression protein A) is a single domain alpha-helical ...
 13-97 1.73e-27

HdeA/HdeB family; HdeA (hns-dependent expression protein A) is a single domain alpha-helical protein localized in the periplasmic space. HdeA is involved in acid resistance essential for infectivity of enteric bacterial pathogens. Functional studies demonstrate that HdeA is activated by a dimer-to-monomer transition at acidic pH, leading to suppression of aggregation by acid-denatured proteins. The gene encoding HdeA was initially identified as part of an operon regulated by the nucleoid protein H-NS. This family also contains HdeB.


Pssm-ID: 428923  Cd Length: 92  Bit Score: 96.30  E-value: 1.73e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 162135912   13 MGAVAALSL-VNAQSALAANESAK------DMTCQEFIDLNPKAMTPVAWWMLHEETVYKGGDTVTLNETDLTQIPKVIE 85
Cdd:pfam06411   1 LLALAAAALaAFSSSAMAQTASATpkkdlsKMTCEDFLDLDEEFKPPVIYWAEGYNSKGKPGDAVIDIEGIEKVTPKVVD 80

                          90
                  ....*....|..
gi 162135912   86 YCKKNPQKNLYT 97
Cdd:pfam06411  81 YCKKNPKASLMD 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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