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Conserved domains on  [gi|16131530|ref|NP_418116|]
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putative transporter YicL [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

DMT family transporter( domain architecture ID 11490012)

DMT (drug/metabolite transporter) family transporter is an inner membrane protein involved in the transport of one or more of a variety of substrates such as amino acids, drugs, metabolites, and sugar phosphates, among others; similar to Escherichia coli biotin transporter and inner membrane transporter YicL

Gene Ontology:  GO:0006810|GO:0005886
PubMed:  11432728
TCDB:  2.A.7.3

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
2A78 TIGR00950
Carboxylate/Amino Acid/Amine Transporter; [Transport and binding proteins, Amino acids, ...
18-287 8.47e-61

Carboxylate/Amino Acid/Amine Transporter; [Transport and binding proteins, Amino acids, peptides and amines]


:

Pssm-ID: 273359 [Multi-domain]  Cd Length: 260  Bit Score: 194.06  E-value: 8.47e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131530    18 WGSSGVCAQYIMEqSQMSSQFLTMTRLIFAGLILLTLSFVHgdkifsiiNNHKDAISLLIFSVVGALTVQLTFLLTIEKS 97
Cdd:TIGR00950   1 WGTTGVVIGQYLE-GQVPLYFAVFRRLIFALLLLLPLLRRR--------PPLKRLLRLLLLGALQIGVFYVLYFVAVKRL 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131530    98 NAATATVLQFLSPTIIVAWFSLVRKSRPGILVFCAILTSLVGTFLLVTHGNptsLSISPAALFWGIASAFAAAFYTTYPS 177
Cdd:TIGR00950  72 PVGEAALLLYLAPLYVTLLSDLMGKERPRKLVLLAAVLGLAGAVLLLSDGN---LSINPAGLLLGLGSGISFALGTVLYK 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131530   178 TLIARYG--TLPVVGWSMLIGGLILLPFYARQGTNFVVNGSLILAFFYLVVIGTSLTFSLYLKGAQLIGGPKASILSCAE 255
Cdd:TIGR00950 149 RLVKKEGpeLLQFTGWVLLLGALLLLPFAWFLGPNPQALSLQWGALLYLGLIGTALAYFLWNKGLTLVDPSAASILALAE 228
                         250       260       270
                  ....*....|....*....|....*....|..
gi 16131530   256 PLSSALLSLLLLGITFTLPDWLGTLLILSSVI 287
Cdd:TIGR00950 229 PLVALLLGLLILGETLSLPQLIGGALIIAAVL 260
 
Name Accession Description Interval E-value
2A78 TIGR00950
Carboxylate/Amino Acid/Amine Transporter; [Transport and binding proteins, Amino acids, ...
18-287 8.47e-61

Carboxylate/Amino Acid/Amine Transporter; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273359 [Multi-domain]  Cd Length: 260  Bit Score: 194.06  E-value: 8.47e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131530    18 WGSSGVCAQYIMEqSQMSSQFLTMTRLIFAGLILLTLSFVHgdkifsiiNNHKDAISLLIFSVVGALTVQLTFLLTIEKS 97
Cdd:TIGR00950   1 WGTTGVVIGQYLE-GQVPLYFAVFRRLIFALLLLLPLLRRR--------PPLKRLLRLLLLGALQIGVFYVLYFVAVKRL 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131530    98 NAATATVLQFLSPTIIVAWFSLVRKSRPGILVFCAILTSLVGTFLLVTHGNptsLSISPAALFWGIASAFAAAFYTTYPS 177
Cdd:TIGR00950  72 PVGEAALLLYLAPLYVTLLSDLMGKERPRKLVLLAAVLGLAGAVLLLSDGN---LSINPAGLLLGLGSGISFALGTVLYK 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131530   178 TLIARYG--TLPVVGWSMLIGGLILLPFYARQGTNFVVNGSLILAFFYLVVIGTSLTFSLYLKGAQLIGGPKASILSCAE 255
Cdd:TIGR00950 149 RLVKKEGpeLLQFTGWVLLLGALLLLPFAWFLGPNPQALSLQWGALLYLGLIGTALAYFLWNKGLTLVDPSAASILALAE 228
                         250       260       270
                  ....*....|....*....|....*....|..
gi 16131530   256 PLSSALLSLLLLGITFTLPDWLGTLLILSSVI 287
Cdd:TIGR00950 229 PLVALLLGLLILGETLSLPQLIGGALIIAAVL 260
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
4-298 3.72e-32

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 120.72  E-value: 3.72e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131530   4 TRKGMLNVLIAAVLWGSSGVCAQYIMEQsqMSSQFLTMTRLIFAGLILLTLSFVHGDKIFSIinNHKDAISLLIFSVVGA 83
Cdd:COG0697   1 RLRGILLLLLAALLWGSSFVAIKLALAG--LPPLQLAFLRFLLAALLLLPLLLLRGRRLPPL--SRRDWLLLLLRGLLGL 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131530  84 LTVQLTFLLTIEKSNAATATVLQFLSPTIIVAWFSLVRKSRPGILVFCAILTSLVGTFLLVTHGNpTSLSISPAALFWGI 163
Cdd:COG0697  77 ALAFLLFFLALQYTPAALAALLLALAPLFVALLAALLLGERLSRRRWLGLLLGFAGVLLIVGPGG-GGGGGSLLGDLLAL 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131530 164 ASAFAAAFYTTYPSTLIARYGTLPVVGWSMLIGGLILLPFYARQGTNFVVNGSLILAFFYLVVIGTSLTFSLYLKGAQLI 243
Cdd:COG0697 156 LAALSWALYTVLTRRLSRRLDPLTLTFWQMLVGALLLLPLALLTGLPLPLSAAAWLALLYLGLFGTALAYLLWFRALRRL 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 16131530 244 GGPKASILSCAEPLSSALLSLLLLGITFTLPDWLGTLLILSSVILISMDSRRRAR 298
Cdd:COG0697 236 GASRAAPLTYLEPVFAVLLGWLLLGEPLTPLQLLGAALILAGVLLAALRERRRAA 290
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
158-291 6.97e-14

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 67.61  E-value: 6.97e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131530   158 ALFWGIASAFAAAFYTTYPSTLIARYGTLPVVGWSMLIGGLILLPFYARQGTNFVVNGSLILAFFYLVVIGTSLTFSLYL 237
Cdd:pfam00892   3 GILLALLAALIWAIYFVFSKILLRRISPLTLTFWRFLIAGILLLPFALFTGGKLVIPLKSWLALLYLGVLGTFLGFLLYF 82
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 16131530   238 KGAQLIGGPKASILSCAEPLSSALLSLLLLGITFTLPDWLGTLLILSSVILISM 291
Cdd:pfam00892  83 YGLKYVSASNASVITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLLILL 136
 
Name Accession Description Interval E-value
2A78 TIGR00950
Carboxylate/Amino Acid/Amine Transporter; [Transport and binding proteins, Amino acids, ...
18-287 8.47e-61

Carboxylate/Amino Acid/Amine Transporter; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273359 [Multi-domain]  Cd Length: 260  Bit Score: 194.06  E-value: 8.47e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131530    18 WGSSGVCAQYIMEqSQMSSQFLTMTRLIFAGLILLTLSFVHgdkifsiiNNHKDAISLLIFSVVGALTVQLTFLLTIEKS 97
Cdd:TIGR00950   1 WGTTGVVIGQYLE-GQVPLYFAVFRRLIFALLLLLPLLRRR--------PPLKRLLRLLLLGALQIGVFYVLYFVAVKRL 71
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131530    98 NAATATVLQFLSPTIIVAWFSLVRKSRPGILVFCAILTSLVGTFLLVTHGNptsLSISPAALFWGIASAFAAAFYTTYPS 177
Cdd:TIGR00950  72 PVGEAALLLYLAPLYVTLLSDLMGKERPRKLVLLAAVLGLAGAVLLLSDGN---LSINPAGLLLGLGSGISFALGTVLYK 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131530   178 TLIARYG--TLPVVGWSMLIGGLILLPFYARQGTNFVVNGSLILAFFYLVVIGTSLTFSLYLKGAQLIGGPKASILSCAE 255
Cdd:TIGR00950 149 RLVKKEGpeLLQFTGWVLLLGALLLLPFAWFLGPNPQALSLQWGALLYLGLIGTALAYFLWNKGLTLVDPSAASILALAE 228
                         250       260       270
                  ....*....|....*....|....*....|..
gi 16131530   256 PLSSALLSLLLLGITFTLPDWLGTLLILSSVI 287
Cdd:TIGR00950 229 PLVALLLGLLILGETLSLPQLIGGALIIAAVL 260
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
4-298 3.72e-32

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 120.72  E-value: 3.72e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131530   4 TRKGMLNVLIAAVLWGSSGVCAQYIMEQsqMSSQFLTMTRLIFAGLILLTLSFVHGDKIFSIinNHKDAISLLIFSVVGA 83
Cdd:COG0697   1 RLRGILLLLLAALLWGSSFVAIKLALAG--LPPLQLAFLRFLLAALLLLPLLLLRGRRLPPL--SRRDWLLLLLRGLLGL 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131530  84 LTVQLTFLLTIEKSNAATATVLQFLSPTIIVAWFSLVRKSRPGILVFCAILTSLVGTFLLVTHGNpTSLSISPAALFWGI 163
Cdd:COG0697  77 ALAFLLFFLALQYTPAALAALLLALAPLFVALLAALLLGERLSRRRWLGLLLGFAGVLLIVGPGG-GGGGGSLLGDLLAL 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131530 164 ASAFAAAFYTTYPSTLIARYGTLPVVGWSMLIGGLILLPFYARQGTNFVVNGSLILAFFYLVVIGTSLTFSLYLKGAQLI 243
Cdd:COG0697 156 LAALSWALYTVLTRRLSRRLDPLTLTFWQMLVGALLLLPLALLTGLPLPLSAAAWLALLYLGLFGTALAYLLWFRALRRL 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 16131530 244 GGPKASILSCAEPLSSALLSLLLLGITFTLPDWLGTLLILSSVILISMDSRRRAR 298
Cdd:COG0697 236 GASRAAPLTYLEPVFAVLLGWLLLGEPLTPLQLLGAALILAGVLLAALRERRRAA 290
RhtA COG5006
Threonine/homoserine efflux transporter RhtA [Amino acid transport and metabolism];
3-300 8.99e-26

Threonine/homoserine efflux transporter RhtA [Amino acid transport and metabolism];


Pssm-ID: 444030 [Multi-domain]  Cd Length: 290  Bit Score: 103.75  E-value: 8.99e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131530   3 STRKGMLNVLIAAVLWGSSGVCAQYIMeqSQMSSQFLTMTRLIFAGLILLTLsFVHGDKIFSIinnhKDAISLLIFSVVG 82
Cdd:COG5006   6 SRLPGVLLVLLSALSVQLGAALAKLLF--PGVGPLGVTALRLAFAALILLLI-FRPWRRRLTR----RDWLALLLYGVAL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131530  83 ALtVQLTFLLTIEKSNAATATVLQFLSPTIIVAWFSLvrksrpGILVFCAILTSLVGTFLLVThGNPTSLSISPAALFWG 162
Cdd:COG5006  79 AG-MNLLFYLAIARIPLGIAVALEFLGPLAVALLGSR------RRRDLLWVALALAGVVLLLP-VGLSGGSLDPVGVLFA 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131530 163 IASAFAAAFYTTYPSTLIARYGTLPVVGWSMLIGGLILLPFYARQGTNFVVNGSLILAFFYLVVIGTSLTFSLYLKGAQL 242
Cdd:COG5006 151 LGAAACWALYILLGRRVGARLPGLTGLALGMLVAALVLLPFGLPTAGPALLDPPVLLLGLGVAVLSSVLPYSLEMVALRR 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 16131530 243 IGGPKASILSCAEPLSSALLSLLLLGITFTLPDWLGTLLILSSVILISMDSRRRARKI 300
Cdd:COG5006 231 LPARTFGILMSLEPAVAALAGWLVLGEVLTPLQWLGIALVVAASAGATLTARRRPPPA 288
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
158-291 6.97e-14

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 67.61  E-value: 6.97e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131530   158 ALFWGIASAFAAAFYTTYPSTLIARYGTLPVVGWSMLIGGLILLPFYARQGTNFVVNGSLILAFFYLVVIGTSLTFSLYL 237
Cdd:pfam00892   3 GILLALLAALIWAIYFVFSKILLRRISPLTLTFWRFLIAGILLLPFALFTGGKLVIPLKSWLALLYLGVLGTFLGFLLYF 82
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 16131530   238 KGAQLIGGPKASILSCAEPLSSALLSLLLLGITFTLPDWLGTLLILSSVILISM 291
Cdd:pfam00892  83 YGLKYVSASNASVITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLLILL 136
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
5-145 9.37e-11

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 58.75  E-value: 9.37e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131530     5 RKGMLNVLIAAVLWGSSGVCAQYIMEQsqMSSQFLTMTRLIFAGLILLTLSFVHGDKIfsiINNHKDAISLLIFSVVGAL 84
Cdd:pfam00892   1 LKGILLALLAALIWAIYFVFSKILLRR--ISPLTLTFWRFLIAGILLLPFALFTGGKL---VIPLKSWLALLYLGVLGTF 75
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16131530    85 TVQLTFLLTIEKSNAATATVLQFLSPTIIVAWFSLVRKSRPGILVFCAILTSLVGTFLLVT 145
Cdd:pfam00892  76 LGFLLYFYGLKYVSASNASVITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLLILL 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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