|
Name |
Accession |
Description |
Interval |
E-value |
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
8-439 |
0e+00 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 836.29 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 8 PADAPLMTDKYEIDARYRYWRRHILLTIWLGYALFYFTRKSFNAAVPEILANGVLSRSDIGLLATLFYITYGVSKFVSGI 87
Cdd:PRK11663 1 PADAPLITDKHEIDARYRYWRRHILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 88 VSDRSNARYFMGIGLIATGIINILFGFSTSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGG 167
Cdd:PRK11663 81 VSDRSNARYFMGIGLIATGIINILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 168 ALIPIVMAAAALHYGWRAGMMIAGCMAIVVGIFLCWRLRDRPQALGLPAVGEWRHDALEIAQQQEGAGLTRKEILTKYVL 247
Cdd:PRK11663 161 ALIPLVVGAIALHYGWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLPSVGEWRHDALELAQQQEGAGLSRKEILTKYVL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 248 LNPYIWLLSFCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLFNGNRGPMNLIFAA 327
Cdd:PRK11663 241 LNPYIWLLSFSYVLVYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDKLFNGNRGPMNLIFAA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 328 GILLSVGSLWLMPFASYVMQATCFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLAGWPLAKVLDTW 407
Cdd:PRK11663 321 GILLSVGSLWLMPFASYVMQAACFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGAALSGYPLAKVLEIW 400
|
410 420 430
....*....|....*....|....*....|..
gi 90111632 408 HWSGFFVVISIAAGISALLLLPFLNAQTPREA 439
Cdd:PRK11663 401 HWTGFFVVISIAAGISALLLLPFLNAQAPREA 432
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
28-431 |
0e+00 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 562.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 28 RRHILLTIWLGYALFYFTRKSFNAAVPEILANGVLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGI 107
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 108 INILFGFSTSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAAAALHYGWRAGM 187
Cdd:cd17488 81 INILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 188 MIAGCMAIVVGIFLCWRLRDRPqalglpavgewrhdaleiaqqqegagltrkeiltkyvllnPYIWLLSFCYVLVYVVRA 267
Cdd:cd17488 161 YVPGIIAILMGIVLCWRLRDRP----------------------------------------PYIWLLAFCYVLVYVVRT 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 268 AINDWGNLYMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLFNGNRGPMNLIFAAGILLSVGSLWLMPFASYVMQ 347
Cdd:cd17488 201 AINDWGNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLFKGNRGPMNLIFALGLLVSVGALWLVPVHSYWLL 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 348 ATCFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLAGWPLAKVLDTWHWSGFFVVISIAAGISALLL 427
Cdd:cd17488 281 ATCFFTIGFFVFGPQMLIGMAAAECSHKDAAGSATGFVGLFAYLGAALAGYPLAKVIESWGWSGFFIVISIAAAISGLLL 360
|
....
gi 90111632 428 LPFL 431
Cdd:cd17488 361 LPLL 364
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
36-413 |
4.06e-162 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 461.85 E-value: 4.06e-162
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 36 WLGYALFYFTRKSFNAAVPEILANGVLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFS 115
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 116 TSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIP-IVMAAAALHYGWRAGMMIAGCMA 194
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPpLVLFGIAELYSWHWVFIVPGIIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 195 IVVGIFLCWRLRDRPQALGLPAVGEWRHDALEIAQQQEGAGLTRKEILTKYVLLNPYIWLLSFCYVLVYVVRAAINDWGN 274
Cdd:TIGR00881 161 IIVSLICFLLLRDSPQSCGLPPAEEMPNEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 275 LYMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLFNGNRGPMNLIFAAGILLSVGSLWLMPFASYVMQATCFFTI 354
Cdd:TIGR00881 241 LYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFAL 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 90111632 355 GFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLAGWPLAKVLDTWHWSGFF 413
Cdd:TIGR00881 321 GFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAGAF 379
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
28-431 |
6.87e-134 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 389.33 E-value: 6.87e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 28 RRHILLTIWLGYALFYFTRKSFNAAVPEILANGVLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGI 107
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 108 INILFGFSTSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAAAALHYGWRAGM 187
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 188 MIAGCMAIVVGIFLCWRLRDRPqalglpavgewrhdaleiaqqqegagltrkeiltkyvllnPYIWLLSFCYVLVYVVRA 267
Cdd:cd17312 161 LVPGIVGLVVAIILFFFLRDSP----------------------------------------PYVWVLSLAYAFVYIVRY 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 268 AINDWGNLYMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLFNGNRGPMNLIFAAGILLSVGSLWLMPfASYVMQ 347
Cdd:cd17312 201 ACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAVIYMLLMTLSLALFWFFP-HNKLLS 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 348 ATCFFTIGFFVFGPQMLIGMAAAECSH-KEAAGAATGFVGLFAYLGASLAGWPLAKVLDTWHWSGFFVVISIAAGISALL 426
Cdd:cd17312 280 IVLLFLIGFFVGGPINLIGGAAAQDIGrKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLL 359
|
....*
gi 90111632 427 LLPFL 431
Cdd:cd17312 360 LLSLW 364
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
28-429 |
1.33e-118 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 352.31 E-value: 1.33e-118
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 28 RRHILLTIWLGYALFYFTRKSFNAAVPEILANGVLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGI 107
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 108 INILFGFS----TSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIV---MAAAALH 180
Cdd:cd17345 81 INILIGFVpsatSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLaglGLAIFGD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 181 YGWRAGMMIAGCMAIVVGIFLCWRLRDRPQALGLPAVGEWRHDALEIAQQQ-EGAGLTRKEILTKYVLLNPYIWLLSFCY 259
Cdd:cd17345 161 GWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIEEYKGDYPEEADGEeEEQELSAWEIFVKYVLKNKLLWYIAIAN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 260 VLVYVVRAAINDWGNLYMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLFNGNRGPMNLIFAAGILLSVGSLWLM 339
Cdd:cd17345 241 VFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKGRRAPTGIIFMILVIVALIVYWLA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 340 PfaSYVMQATCFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYL-GASLAGWPLAKVLDTWHWSGFFVVISI 418
Cdd:cd17345 321 P--NVLVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYLgGSVLATALIGIIVDHFGWNGGFIVLLA 398
|
410
....*....|.
gi 90111632 419 AAGISALLLLP 429
Cdd:cd17345 399 SCILAIIFLAL 409
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
1-431 |
1.37e-92 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 286.99 E-value: 1.37e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 1 MLPFLK-APADAPLMTDkyEIDARYRYWRRHILLTIWLGYALFYFTRKSFNAAVPEILANGvLSRSDIGLLATLFYITYG 79
Cdd:PRK11273 1 MLSIFKpAPHKARLPAA--EIDPTYRRLRWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQG-FSRGDLGFALSGISIAYG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 80 VSKFVSGIVSDRSNARYFMGIGLIATGIINILFGF----STSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGW 155
Cdd:PRK11273 78 FSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGFvpwaTSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGI 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 156 WALWNTAHNVGGALI-PIVMAAAALHYGWRAGMMIAGCMAIVVGIFLCWRLRDRPQALGLPAVGEWRHDALEIAQQQEGA 234
Cdd:PRK11273 158 VSVWNCAHNVGGGLPpLLFLLGMAWFNDWHAALYMPAFAAILVALFAFAMMRDTPQSCGLPPIEEYKNDYPDDYNEKHEQ 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 235 GLTRKEILTKYVLLNPYIWLLSFCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLF 314
Cdd:PRK11273 238 ELTAKQIFMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVF 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 315 NGNRGPMNLIFAAGILLSVGSLWLMPFASYVMQATCFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGAS 394
Cdd:PRK11273 318 RGNRGATGVFFMTLVTIATIVYWLNPAGNPTVDMACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGS 397
|
410 420 430
....*....|....*....|....*....|....*...
gi 90111632 395 LAGWP-LAKVLDTWHWSGFFVVISIAAGISALLLLPFL 431
Cdd:PRK11273 398 VAASAiVGYTVDFFGWDGGFMVMIGGSILAVILLIVVM 435
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
31-433 |
1.12e-88 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 275.37 E-value: 1.12e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 31 ILLTIWLGYALFYFTRKSFNAAVPEILANGVLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINI 110
Cdd:cd17343 4 IFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 111 LFGFSTSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAAAALHYGWRAGMMIA 190
Cdd:cd17343 84 AFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTLSIS 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 191 GCMAIVVGIFLCWRLRDRPQALGLPavgewrhDALEIAQQQEGAGLTRKEILTKYVLLNPYIWLLSFCYVLVYVVRAAIN 270
Cdd:cd17343 164 GTVAVVMSVVCLLFIKNEPSDVGLN-------NIEEEESKGKKKKSPRGESTLKELLLSPFLWLLSLGYLVVFGVKTAVT 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 271 DWGNLYMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLF--NGN------RGPMNLIFAAGILLSVGSL--WLMP 340
Cdd:cd17343 237 DWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVakHGSssrgnpRMPLALVFMAGLTVSLHLFrvHITS 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 341 FASYVMQATCFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLAGWPLAKVLDTWHWSGFFVVISIAA 420
Cdd:cd17343 317 DSSELFILLLGFLIGFSLYGPIAIFGVIANESAPSHLCGTSHAIVALAANVGGVLAGLPFSYIAKHYDWRTAFLLLEILC 396
|
410
....*....|...
gi 90111632 421 GISALLLLPFLNA 433
Cdd:cd17343 397 AITVVILFLLRNI 409
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
20-429 |
1.59e-73 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 238.02 E-value: 1.59e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 20 IDARYRYWRRHIL---LTIWLGYALFYFTRKSFNAAVPEILANGVLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARY 96
Cdd:PRK09556 16 LEVQRKMWFKPFMqsyLVVFIGYLTMYLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKQ 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 97 FMGIGLIATGIINILFGFS-----TSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIP 171
Cdd:PRK09556 96 FLPFLLILSAICMLGFGASlgsgsVSLGLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGAGAG 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 172 IV--MAAAALHYGWRAGMMI-AGCMAIVVGIFLCWRLRDRPQALGLPAVGEWRHDALEIAQ-QQEGAGLTRKEILTKYVL 247
Cdd:PRK09556 176 GValWGANYFFDGHVIGMFIfPSIIALIIGFIGLRYGSDSPEELGWGKAEEIFGEPISEEDkETESTDMTKWQIFVEYVL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 248 LNPYIWLLSFCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLfNGNRGpmnLIFAA 327
Cdd:PRK09556 256 KNPVIWLLCFANIFLYIVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDLA-NGRRA---LVACI 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 328 GILLSVGSLWLMPFA-SYVMQATCFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYL-GASLAGWPLAKVLD 405
Cdd:PRK09556 332 ALALIIFTLGVYQHAtSEYMYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGVANGIKGTFAYLfGDSFAKVGLGMIAD 411
|
410 420 430
....*....|....*....|....*....|....*.
gi 90111632 406 TWH------------WSGFFVVISIAAGISALLLLP 429
Cdd:PRK09556 412 PTKngtpifgytltgWAGTFAALDIAAIGCICLMAI 447
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
21-431 |
2.55e-62 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 205.87 E-value: 2.55e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 21 DARYRYWRRHILLTIWLGYALFYFTRKSFNAAVPEILANGVLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGI 100
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 101 GLIATGIINILFGFSTSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAAAALH 180
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 181 YGWRAGMMIAGCMAIVVGIFlcwrlrdrpqalglpavgewrhdaleiaqqqegagltrkeiltkyvllnpYIWLLSFCYV 260
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALL--------------------------------------------------RFWLLALAYF 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 261 LVYVVRAAINDWGNLYMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLFNGNRGPMnlifAAGILLSVGSLWLMP 340
Cdd:COG2271 191 LVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVL----AIGLLLAALALLLLA 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 341 FA-SYVMQATCFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLAGWPLAKVLDTWHWSGFFVVISIA 419
Cdd:COG2271 267 LLpSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAAL 346
|
410
....*....|..
gi 90111632 420 AGISALLLLPFL 431
Cdd:COG2271 347 ALLAALLALLLL 358
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
35-396 |
1.02e-33 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 129.46 E-value: 1.02e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 35 IWLGYALFYFTRKSFNAAVPEILANGV-LSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFG 113
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLgISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 114 FSTSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAAAALHYGWRAGMMIAGCM 193
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 194 AIVVGIFLcWRLRDRPQALGLPAVGEWRHDALEiaqqqegagltrkeiLTKYVLLNPYIWLLsFCYVLVYVVRAAINDWG 273
Cdd:pfam07690 161 SLLAAVLL-LLPRPPPESKRPKPAEEARLSLIV---------------AWKALLRDPVLWLL-LALLLFGFAFFGLLTYL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 274 NLYMsETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLfnGNRGPMNLIFAAGILLSVGSLWLMPFASYVMQATCFFT 353
Cdd:pfam07690 224 PLYQ-EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRL--GRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLL 300
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 90111632 354 IGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLA 396
Cdd:pfam07690 301 LGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
36-428 |
1.06e-32 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 127.35 E-value: 1.06e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 36 WLGYALFYFTRKSFNAAVPEILANGVLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFS 115
Cdd:cd17475 2 TLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 116 TSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAAAALHYGWRAGMMIAGCMAI 195
Cdd:cd17475 82 GSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 196 VVGIFLCWRLRDRPQALGLPAVGEWRHDALeiaqqqegagltrkeiltKYVLLNPYIWLLSFCYVLVYVVRAAINDWGNL 275
Cdd:cd17475 162 LAAVLFWLFYREPPAASAATESASTLLRSL------------------KEVLRNRDVWLIAIAGALLVAPQFALLTFLLL 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 276 YMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLFNGNR-GPMNLIFAAGILLSVGSLWLMPFASYVMQATCFFTI 354
Cdd:cd17475 224 FLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGRRrPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILL 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 90111632 355 GFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGAsLAGWPL--AKVLDTWHWSGFFVVISIAAGISALLLL 428
Cdd:cd17475 304 GLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGI-AIGPPLfgLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
25-396 |
1.47e-30 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 120.46 E-value: 1.47e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 25 RYWRRHILLTIWLGYALFYFTRKSFNAAVPEILANGVLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIA 104
Cdd:COG2814 5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 105 TGIINILFGFSTSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAAAALHYGWR 184
Cdd:COG2814 85 FALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 185 AGMMIAGCMAIVVGIFLCWRLRDRPQALGLPAVGEWRHdaleiaqqqegagltrkeiltkyVLLNPYIWLLSFCYVLVYV 264
Cdd:COG2814 165 WVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRE-----------------------LLRRPRLLLLLLLAFLLGF 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 265 VRAAINDWGNLYMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLfngnrGPMNLIFAAGILLSVGSLWLMPFASY 344
Cdd:COG2814 222 GFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF-----GRRRLLLIGLLLLALGLLLLALAGSL 296
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 90111632 345 VMQATCFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLA 396
Cdd:COG2814 297 WLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
35-428 |
3.14e-30 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 120.22 E-value: 3.14e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 35 IWLGYALFYFTRKSFNAAVPEILANGVLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGF 114
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 115 STSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAAAALH--YGWRAGMMIAGC 192
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 193 MAIVVGIFLCWRLRDRPQalglpavgewrhdalEIAQQQEGAGLTRKEILTKYVLLNPYIWLLSFCYVLVYVVRAAINDW 272
Cdd:cd06174 161 LALLAAILLLLVVPDPPE---------------SARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 273 GNLYMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLFngnrGPMNLIFAAGILLSVGSLWLMPFASYVMQATCFF 352
Cdd:cd06174 226 LPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLI----GRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLL 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 90111632 353 TIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLAGWPLAKVLDTWHWSGFFVVISIAAGISALLLL 428
Cdd:cd06174 302 LLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
28-428 |
2.18e-28 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 114.98 E-value: 2.18e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 28 RRHILLTIWLGYALFYFTRKSFNAAVPEILANGVLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGI 107
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 108 INILFGFSTSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAAAALHYGWRAGM 187
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 188 MIAGCMAIVVGIFLCWRLRDrpqalglpavgewrhdaleiaqqqegagltrkeiltkyvllnpyIWLLSFCYVLVYVVRA 267
Cdd:cd17319 161 IIEGLLGLLLAVLWWFYLRQ--------------------------------------------VWGLALGYFGINYALY 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 268 AINDWGNLYMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLFNGNRGPMnlIFAAGILLSVGSLWLMPFASYVMQ 347
Cdd:cd17319 197 GLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLV--IIIGLLLAAVGLLLAYLTTSPVVA 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 348 ATCFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLAGWPLAKVLDTWH-WSGFFVVISIAAGISALL 426
Cdd:cd17319 275 VILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGsYTAAFLFLAAVALLAALL 354
|
..
gi 90111632 427 LL 428
Cdd:cd17319 355 VL 356
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
28-439 |
2.51e-28 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 115.36 E-value: 2.51e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 28 RRHILLTIWLGYALFYFTRKSFNAAVPEILANGVLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGI 107
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 108 INILFGFSTSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAAAALHYGWRAGM 187
Cdd:COG2223 83 GLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 188 MIAGCMAIVVGIFLCWRLRDRPQALGLPAVGEWRHdaleiaqqqegagltrkeilTKYVLLNPYIWLLSFCYVLVYVVRA 267
Cdd:COG2223 163 LILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRD--------------------QLEALRDPRFWLLSLLYFGTFGSFI 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 268 AINDWGNLYMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLfngnrGPMNLIFAAGILLSVGSLWLMPFASYVMQ 347
Cdd:COG2223 223 GFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRI-----GGRRVLLIVFALMALGLLLLALALGSLWL 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 348 ATCFFTIGFFVFGPQMLIGMA-AAECSHKEAAGAATGFVGLFAYLGASLAGWPLAKVLD-TWHWSGFFVVISIAAGISAL 425
Cdd:COG2223 298 FLVLFLLLGLALGGGNGAVFAlVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDaTGSYTAAFLVFAVLALVALV 377
|
410
....*....|....
gi 90111632 426 LLLPFLNAQTPREA 439
Cdd:COG2223 378 LTLLLYRRPRRAAA 391
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
37-428 |
6.99e-27 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 111.27 E-value: 6.99e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 37 LGYALFYFTRKSFNAAVPEILANGVLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFST 116
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 117 SLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAAAALHYGWRAGMMIAGCMAIV 196
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGII 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 197 VGIFLCWRLRDRPQALGL--PAVGEWRHDALEIAQQQEGAGLTRKEILTKYvLLNPYIWLLSFCYVLVYVVRAAINDWGN 274
Cdd:TIGR00893 161 WGVLWLKFIPDPPQKAKWltEEEKYIVVGGLLAEQQGKGPSTPKKYQIKEL-LKDRRVWGLALGQFLVNIGLGFFLTWFP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 275 LYMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLFNGNRGPMNLIFAAGILLSVGSLWLMPFASYVMQATCFFTI 354
Cdd:TIGR00893 240 TYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAIIAGLVLSLLMFATNYVNIPYAALALV 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 90111632 355 GFFVFGPQMLIGMAA--AECSHKEAAGAATGFVGLFAYLGaSLAGWPLAKVLD--TWHWSGFFVVISIAAGISALLLL 428
Cdd:TIGR00893 320 ALGFFGLGAGAIGWAliSDNAPGNIAGLTGGLINSLGNLG-GIVGPIVIGAIAatTGSFAGALMVVAALALIGALSYL 396
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
31-431 |
8.04e-23 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 99.70 E-value: 8.04e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 31 ILLTIWLGYALFYFTRKSFNAAVPEILANGVLSRSD-------------------------IGLLATLFYITYGVSKFVS 85
Cdd:cd17342 4 VFILTFFSYALLHATRKTFSNVKPSISAEWTPSNSNtsielheetwnanplfpsqddaalfLGVLDTIFLFSYAIGLFIS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 86 GIVSDRSNARYFMGIGLIATGIINILFGFST------SLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALW 159
Cdd:cd17342 84 GWLGDRLNLRLVLAFGMCSSAITVFLFGVLTewlhfyNKYLYCILWVLNGLLQSTGWPCVVAIMGNWFGKSSRGFVLGLW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 160 NTAHNVG---GALIpivmAAAALHYGWRAGMMIAGCMAIVVGIFLCWRLRDRPqalglpavgewrhdaleiaqqqegagl 236
Cdd:cd17342 164 SACASVGniiGALL----ASSVLDYGYEYAFLVTSSLLFAGAIVVFFGLLSSP--------------------------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 237 trkeiltkyvllnPYIWLLSFCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLfnG 316
Cdd:cd17342 213 -------------PGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFHWKESEADQLSIWYDVGGIIGGIVAGYISDRM--G 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 317 NRGPMNLIFaagILLSVGSLWLMPFA--SYVMQATCFFTIGFFVFGPQMLI--------GMAAAECSHKEAAGAATGFVG 386
Cdd:cd17342 278 SRSPVVVVM---LLLAIPSLFVYSHSpsDKVLNAFVMTITGFFIGGPANLIssaisadlGRQPQLRGSSEALATVTGIID 354
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 90111632 387 LFAYLGASLAGWPLAKVLDTWHWSGFFVVISIAAGISALLLLPFL 431
Cdd:cd17342 355 GTGSIGAAIGQVLVPLIQNRLGWMWVFYFFIIMTILTIVCILPLL 399
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
67-431 |
3.58e-21 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 94.69 E-value: 3.58e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 67 IGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFST-----SLWAFAVLWVLNAFFQGWGSPVCAR 141
Cdd:cd17344 64 LGALDSAFLFAYAIGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFGLGYywnihSLWYFVVVQILAGLFQSTGWPSVVA 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 142 LLTAWYSRTERGGWWALWNtAHNVGGALIPIVMAAAALHYGWRAGMMIAGCMAIVVGIFLCWRLRDRPqalglPAVGEWr 221
Cdd:cd17344 144 CVGNWFGKGKRGLIMGIWN-SHTSVGNILGSLIAGIFVSSAWGLSFIVPGIIIAAMGVLVFLFLVEHP-----PGVIEF- 216
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 222 hdaleiaqqqegagltrkeiltkyvllnpyiwllSFCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVTMFELGGFI 301
Cdd:cd17344 217 ----------------------------------SLCLFFAKLVSYTFLYWLPLYISNTAILSAKKAGDLSTLFDVGGIV 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 302 GALVAGWGSDKLfnGNR----GPMnLIFAAGILL---SVGSLWLmpFASYVMQATCfftiGFFVFGPQMLIGMA-AAEC- 372
Cdd:cd17344 263 GGILAGYISDYT--GGRattcAAM-LILAAPMLFiynYFGQVSM--TTNIVLLIVC----GLLVNGPYALITTAvSADLg 333
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 90111632 373 SHKEAAGAA------------TGFVGlfAYLGASLAGWplakvLDTWHWSGFFVVIsIAAGISALLLLPFL 431
Cdd:cd17344 334 THKSLKGNAralatvtaiidgTGSIG--AALGPLLAGL-----ISSRGWNNVFYML-IAADVCAGLLLTRL 396
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
28-428 |
7.22e-20 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 90.68 E-value: 7.22e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 28 RRHILLTIWLGYALFYFTRKSFNAAVPEILANGVLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGI 107
Cdd:COG0738 6 YRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 108 INILFGFSTSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTER------GGWWALWNTAhnvgGALIPIVMAAAALHY 181
Cdd:COG0738 86 GLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAAsrlnllHAFFSLGALL----GPLLGGLLILLGLSL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 182 GWRAGMMIAGCMAIVVGIFLcwrlrdrpqalglpavgeWRHDALEIAQQQEGAGLTRKEilTKYVLLNPYIWLLS---FC 258
Cdd:COG0738 162 SWHLPYLILAVLLLLLALLF------------------LRSKLPEIEEEEEEAAGSAAS--LKSLLKNPRLLLGGlaiFL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 259 YVLVYVvraAINDWGNLYMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLfngnrGPMNLIFAAGILLSVGSLWL 338
Cdd:COG0738 222 YVGAEG---AIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF-----GPVRLLRLSALLAAVGLLLA 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 339 MPFASYVMQATCFFTIGFFVfGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLAGWPLAKVLDTWHWSGFFVVISI 418
Cdd:COG0738 294 LLAPGPWLALIGLALVGLGL-SLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLV 372
|
410
....*....|
gi 90111632 419 AAGISALLLL 428
Cdd:COG0738 373 CYLLILLLAL 382
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
67-428 |
1.80e-19 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 89.56 E-value: 1.80e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 67 IGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSTSLWAFAVLWVLNAFFQGWGSPVCARLLTAW 146
Cdd:cd17325 33 IGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 147 YSRTERGGWWALWNTAHNVGGALIPIVMAAAALHYGWRAGMMIAGCMAIVVGIFLCWRLRDRPqalglpavgewrhdale 226
Cdd:cd17325 113 APPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPR----------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 227 IAQQQEGAGLTRKEILTKYVLLNPYIWLLSFCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVTMFELGGFIGALVA 306
Cdd:cd17325 176 PPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPA 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 307 GWGSDKLfnGNRGPMnlifAAGILLSVGSLWLMPFA-SYVMQATCFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFV 385
Cdd:cd17325 256 GKLSDRI--GRKPLI----LIGLLLSAVALLLLPLAtSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLF 329
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 90111632 386 GLFAYLGASLAGWPLAKVLDTWHWSGFFVVISIAAGISALLLL 428
Cdd:cd17325 330 NTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFL 372
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
51-428 |
2.01e-19 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 89.15 E-value: 2.01e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 51 AAVPEILANGVLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSTSLWAFAVLWVLNAF 130
Cdd:cd17478 17 ALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 131 FQGWGSPVCARLLTAwYSRTERGGWWALWNTAHNVGGALIPIVMAAAALHYGwRAGMMIAGCMAIVVGIFLCWRlrdrpq 210
Cdd:cd17478 97 GSAAFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFG-GLGLLILLIIPGLAVALLLLR------ 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 211 alglpavgeWRHDALEIAQQQEGAGLTRKEILTKYVLLNPyIWLLSFCYVLVYvvrAAINDWGNLYMSETlGVDLVTANT 290
Cdd:cd17478 169 ---------LRPLKKPEAKKAAAKSSARSTLKGVWRALLL-LLIIVFLRSWVL---SSLTTFLPFYLVQR-GYSLVFAGL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 291 AVTMFELGGFIGALVAGWGSDKLfnGNRgpmnLIFAAGILLSVGSLWLMPFASYVMQATCFFTIGFFVFGPQMLIGMAAA 370
Cdd:cd17478 235 LLSLFLFAGAIGTLIGGPLSDRF--GRR----RVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQ 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 90111632 371 ECSHkEAAGAATGFVGLFAYLGASLAGWPLAKVLDTWHWSGFFVVISIAAGISALLLL 428
Cdd:cd17478 309 ELLP-GNVGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
30-358 |
1.77e-15 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 77.67 E-value: 1.77e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 30 HILLTIWLGYALFYFTRKSF-NAAVPEILANGVLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGII 108
Cdd:cd17327 5 FILPLLCILYFLQYLDKSNIsNAAVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 109 NILFGFSTSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIvMAAAALH-------Y 181
Cdd:cd17327 85 TLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGL-LAYGVFKilgvgglA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 182 GWRAGMMIAGCMAIVVGIFLCWRLRDRPQALGLPAVGEWRHDALEIAQQQEGAGLTRKEI-LTKYVLLNPYIWLLSFCYV 260
Cdd:cd17327 164 GWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRANQTGKGDQKFKWkQIKEAFKDPRTWLLFLFFF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 261 LVYVVRAAINDWGNLYMSETLGVDLVTANTAVTMFELgGFIGALVAGWGSDKLfnGNRGPMNLIFAAGILLSVGSLWLMP 340
Cdd:cd17327 244 CSQITNNGISNFLPLILKSLGFYSLQTNLLSVPIGAL-GAVSLLIAALLSDRF--KKRGLFAIFACVLALVGSIILLAAP 320
|
330
....*....|....*...
gi 90111632 341 FASYVMQATCFFTIGFFV 358
Cdd:cd17327 321 NPPGAYFAAYILGGGSYA 338
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
62-428 |
4.80e-15 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 76.45 E-value: 4.80e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 62 LSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSTSLWAFAVLWVLNAFFQGWGSPVCAR 141
Cdd:COG2807 50 LSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPG 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 142 LLTAWYSRtERGGWWALWNTAHNVGGALIPIVMAAAALHYGWRAGMMIAGCMAIVVGIFLCWRLRDRPQalglpavgewr 221
Cdd:COG2807 130 LIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPA----------- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 222 hdaleiAQQQEGAGLTRKEILTkyvllNPYIWLLSFCYVLVYVVRAAINDWGNLYMSEtLGVDLVTANTAVTMFELGGFI 301
Cdd:COG2807 198 ------AAAAAPAAASLRSLWR-----SPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLSLFQLAGIP 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 302 GALVAGWGSDKLfnGNRGPMNLIFAAGILLSVGSLWLMPFASYVMQATCFFTIGFFVFGpqMLIGMAAAECSHKEAAGAA 381
Cdd:COG2807 266 GSLLVPLLADRL--GDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFP--LALTLIGLRARTPAEAAAL 341
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 90111632 382 TGFVGLFAYLGASLAGWPLAKVLDTWH-WSGFFVVISIAAGISALLLL 428
Cdd:COG2807 342 SGMAQSVGYLLAALGPLLVGALHDATGsWTAALLLLAALAVLMLVAGL 389
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
63-428 |
6.54e-15 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 75.77 E-value: 6.54e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 63 SRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSTSLWAFAVLWVLNAFFQ-GWGSPVCAR 141
Cdd:cd17355 36 SRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGaGTLAAVAFA 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 142 LLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAAAALHYGWRAGMMIAGCMAIVVGIFLCWRLRDRPQALGLPAVGEWR 221
Cdd:cd17355 116 TVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDAS 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 222 HdaleiaqqqEGAGLTRKEILTkyvllNPYIWLLSFCYVLVYVVRAAINDWGNLYMSEtLGVDLVTANTAVTMFELGGFI 301
Cdd:cd17355 196 P---------ASPGSTLKEALR-----SASFWLLALAFFLCGFAVVGLIVHLVPYLAD-RGISPAAAAVALALIGLFNIV 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 302 GALVAGWGSDKLfngNRGPMNLIFAAGILLSVGSLWLMPFASYVMQATCFFtIGFFVFGPQMLIGMAAAECSHKEAAGAA 381
Cdd:cd17355 261 GRLLSGWLGDRY---SPRRLLAASYALRALGLALLLLLPFPPLALLLFAAL-FGLGWGATVPLTAALAARYFGARSYGTL 336
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 90111632 382 TGFVGLFAYLGASLAGWPLAKVLDTWHWSGFFVVISIAAGISALLLL 428
Cdd:cd17355 337 FGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLV 383
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
37-359 |
8.02e-13 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 69.57 E-value: 8.02e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 37 LGYALFYFTRKSFNAAVPEILANGVLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFST 116
Cdd:cd17328 6 LINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 117 SLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIV-MAAAALHYGWRAGMMIAGCMAI 195
Cdd:cd17328 86 NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVgGLVAQATGGWRWAFRVTGVLGV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 196 VVGIFLCWRLRDRPQAlglpavgewrhdaleIAQQQEGAGLTRKEIL--TKYVLLNPYIWLLSFCYVLVYVVRAAINDWG 273
Cdd:cd17328 166 LLAILLLLFVREPPRG---------------AAEGGVMAKSTATSFLadLKALAKNPSFILSTLGFTAVSFVTGALAFWA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 274 NLYMSETLGVDLVTANTAVTMFEL----GGFIGALVAGWGSDKLFNGNRGPMNLIFAAGILLSVGSLWL-MPFASYVMQA 348
Cdd:cd17328 231 PTFFLRAFGVGDLSSADVGLIFGAitciAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAAPFLFLaLVLALSNLLL 310
|
330
....*....|...
gi 90111632 349 T--CFFTIGFFVF 359
Cdd:cd17328 311 AwvLLFLGEFLLS 323
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
28-201 |
1.09e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 69.14 E-value: 1.09e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 28 RRHILLTIWLGYALFYFTRKSFNAAVP-EILANGVLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATG 106
Cdd:cd17325 197 RDRRLLALFLAIFVLAFAFGALEPFLPlYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSA 276
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 107 IINILFGFSTSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAAAALHYGWRAG 186
Cdd:cd17325 277 VALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATP 356
|
170
....*....|....*
gi 90111632 187 MMIAGCMAIVVGIFL 201
Cdd:cd17325 357 FLAAAALLLLAAVLF 371
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
32-428 |
3.91e-12 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 67.24 E-value: 3.91e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 32 LLTIWLGYALFYFTRKSFNAAVPEI--LANGVLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIIN 109
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLaaEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 110 ILFGFSTSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVG----GALIPIVMAAAALHYGWRA 185
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGallaALVASLLIPLLSGDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 186 GMMIAGCMAIVVgiflcwrlrdrpqalglpavgewrhdaleiaqqqegagltrkeiltkyVLLNPYIWLLSFCYVLVYVV 265
Cdd:cd17316 161 LFLIGALPALLA------------------------------------------------LLLRRRTLLLILLWFFISFG 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 266 RAAINDWGNLYMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLfngNRGPMNLIFAAGILLSVGSLWLMPFASYV 345
Cdd:cd17316 193 YYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI---GRKKTLVIGLILSGILALPLFYLLSGSPT 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 346 MQATCFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLAGWPLAKVLDTWHWSGFFVVISIAAGISAL 425
Cdd:cd17316 270 LLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVAL 349
|
...
gi 90111632 426 LLL 428
Cdd:cd17316 350 IVA 352
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
62-428 |
1.38e-11 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 65.65 E-value: 1.38e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 62 LSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSTSLWAFAVLWVLNAFFQGWGSPVCAR 141
Cdd:cd17324 31 VSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 142 LLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAAAALHYGWRAGMMIAGCMAIVVGIFLCWRLRDRP--QALGLPAVGE 219
Cdd:cd17324 111 YAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPpkKPGSLGLLSS 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 220 WRHdaleiaqqqegagltrkeiltkyVLLNPYIWLLSFCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVTMFELGG 299
Cdd:cd17324 191 LLL-----------------------LLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 300 FIGALVAGWGSDklfngnRGPMNLIFAAGILLSVGSLWLMPFASYVMQ---ATCFFTIGFFVFGP--QMLIGMAAaecsh 374
Cdd:cd17324 248 VVGSPLAGRLAD------RGGRRALLIALLLLAAALLLLTLLGPSPLLllvGLVLWGLGFFAAHSalQTRVLRLA----- 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 90111632 375 KEAAGAATGFVGLFAYLGASLAGWPLAKVLDTWHWSGFFVVISIAAGISALLLL 428
Cdd:cd17324 317 PEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
32-210 |
1.42e-11 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 65.66 E-value: 1.42e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 32 LLTIWLGYALFYFTRKSFNAAVPEILANGV-LSRSDIGLLATLFYITYGVSKFVSGIVSDR--SNARYFMGIGLIATGII 108
Cdd:COG2271 182 FWLLALAYFLVYFALYGFLTWLPTYLVEVRgLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRlgRRRKLVLAIGLLLAALA 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 109 NILFGFSTSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAAAALHYGWRAGMM 188
Cdd:COG2271 262 LLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFL 341
|
170 180
....*....|....*....|..
gi 90111632 189 IAGCMAIVVGIFLCWRLRDRPQ 210
Cdd:COG2271 342 LLAALALLAALLALLLLRETRK 363
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
51-428 |
2.81e-10 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 61.45 E-value: 2.81e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 51 AAVPEILANGVLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSTSLWAFAVLWVLNAF 130
Cdd:cd17365 20 FVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 131 FQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAAAALHYGWRAGMMIAGCMAIVVGIFLcwrlrdrpq 210
Cdd:cd17365 100 GLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLL--------- 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 211 alglpavgewrhdaleiaqqqeGAGLTrkeiltkyvllnpyIWLLSFC-YVLVYVVraaiNDWGNLYMSETlGVDLVTAN 289
Cdd:cd17365 171 ----------------------RGTLL--------------LWVTFFMgLLLVYLL----NSWLPKLMVEA-GYSLSQAL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 290 TAVTMFELGGFIGALVAGWGSDKlfnGNRGPMNLIFAAGILLSVGSLWLMPFaSYVMQATCFFTIGFFVFGPQMLIGMAA 369
Cdd:cd17365 210 TITLLLNIGGVIGSLLLGWLADR---FGPKRVLALFFALGAVSLALLGVSPA-SLVLLYVLVFLAGACVNGAQVGLYALA 285
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 370 AECSHKEAAGAATGFVGLFAYLGASLAGWPLAKVLD-TWHWSGFFVVISIAAGISALLLL 428
Cdd:cd17365 286 ARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLLAaGLGPESVFLALAIPAALGALAVL 345
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
52-428 |
3.94e-10 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 61.05 E-value: 3.94e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 52 AVPEILANGVLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSTSLWAFAVLWVLNAFF 131
Cdd:cd17320 21 ALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 132 QGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAAAALHYGWRAGMMIAGCMAIVVGIFLCWRLRdrpqa 211
Cdd:cd17320 101 AAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLP----- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 212 lglpavgewrhdalEIAQQQEGAGLTRKEILT-KYVLLNPYIWLLSFCYVLVYVVRAA-INDWGNLYMsETLGVD----- 284
Cdd:cd17320 176 --------------ETLPEEKRKPLLSSLLRAyKRVLKNRRFLGYALALGLSFAGLFAyLAAAPFIYI-EQLGLSpaqfg 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 285 LVTANTAVTMFeLGGFI-GALVAGWGSDKLFngnRGPMNLIFAAGILLSVGSLWLMPFASYVMQATCFFTIGFFVFGPqm 363
Cdd:cd17320 241 LLFALNAIALI-LGSLLnGRLVRRFGPRRLL---RLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFP-- 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 90111632 364 lIGMAAAECSHKEAAGAATGFVGLFAYLGASLAGWPLAKVLDTWHWSgfFVVISIAAGISALLLL 428
Cdd:cd17320 315 -NATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPNGTALP--MGLLILVLGLLALLLL 376
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
62-428 |
4.96e-10 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 60.70 E-value: 4.96e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 62 LSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSTSLWAFAVLWVLNAFFQGWGSPVCAR 141
Cdd:cd17329 32 LSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 142 LLTAWYSRTERGGWWALWNTAHNVGGALIPIVmAAAALHYGWRAGMMIAGCMAIVVGIFLCWRLrdrpqalglpavgewR 221
Cdd:cd17329 112 MIADVTTPENRTRAFSLLYWAINLGVAIGPLL-GGLLLLYSFRLLFLAAAVLFLLAALVLLFLL---------------P 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 222 HDALEIAQQQEGAGLTRKeiltKYVLLNPYIWLLSFCYVLVYVVRAAINDWGNLYMSETLGVD------LVTANTAVTmf 295
Cdd:cd17329 176 ETRPKRRAAEKTEILRGY----KIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGesllglLLALNALLI-- 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 296 elggfigalVAGWGSDKLFNGNRGPMNLIFAAGILLSVGSLWLMPFASYVM--QATCFFTIGFFVFGPqmLIGMAAAECS 373
Cdd:cd17329 250 ---------VLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVliLAMIVLTLGEMLVFP--AVQTLVAALA 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 90111632 374 HKEAAGAATGFVGLFAYLGASLAGWPLAKVLDTWHWSGFFVVISIAAGISALLLL 428
Cdd:cd17329 319 PPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLL 373
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
28-430 |
1.88e-09 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 59.16 E-value: 1.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 28 RRHILLTIWLGYALFYFTRKSFNAAVPEILANGVLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGI 107
Cdd:cd17353 1 RRWLVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 108 INILFGFSTSLW-AFAVLWVLNAFFQGWGSPVCARLLTAWYSrtERGGWWALWNTAHNVGGALIPIVMAAAAL-HYGWRA 185
Cdd:cd17353 81 GFILSAFAISLPlLFLGYGVLGGIGAGIGYITPVSTAVKWFP--DKRGLATGIVIAGFGLGSLIFSPLIAYLInTVGVPT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 186 GMMIAGCMAIVVGIFLCWRLRDRPQALGLPAVgewrhDALEIAQQQEGAGLTRKEILTKYVLLNPYIWLLSFCYVLVYVv 265
Cdd:cd17353 159 TFLILGIIFLIIIVIGAFLIRDPPKGWVPPGV-----DPLANNAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGLML- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 266 raaINDWGNlYMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLfngnrGPMNLIFAAGILLSVGSLWLMPFASYV 345
Cdd:cd17353 233 ---IGQAKP-IGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKI-----GRKNTLSIAFLIQGVAMFLLPFIGSVA 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 346 MQATCFFTIGFFVFGPqmLIGMAAAECSHK---EAAGAATGFVgLFAYLGASLAGWPL-AKVLDTWHWSGFFVVISIAAG 421
Cdd:cd17353 304 VLFVLGVALIGFCYGG--GFALFPALTADFfgtKNAGTNYGLL-YTAKGVGGLIGPIIaAYVLYTGGYNAAFIIAAALSL 380
|
....*....
gi 90111632 422 ISALLLLPF 430
Cdd:cd17353 381 VALALALLL 389
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
36-431 |
2.48e-09 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 58.85 E-value: 2.48e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 36 WLGYALFYFTRKSFNAAVPEILANGVLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFS 115
Cdd:cd17371 5 FLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 116 TSLWAFAVLwvlnAFFQGWGSP---VCARLLTAWYSRTE-RGGWWALWNTAHNVGG----ALIPIVMAAAALHYGWRAGM 187
Cdd:cd17371 85 QNYWQLLIL----RALAGLGFGgewAAGAALMAEYVPARhRGKALGYVQSGWAVGWllatLLAALLFPLLPPEIAWRVLF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 188 MIAGCMAIVVgIFLCWRLRDRPQALglpavgewrhdALEIAQQQEGAGLTRKEILTKYVLLNPYIWLLSFCYVLVyvVRA 267
Cdd:cd17371 161 LLGALPALLV-LFIRRFVKEPPQWQ-----------AARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALG--GYY 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 268 AINDWGNLYMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLfngNRGPMNLIFAAGILLSVgsLWLMPF-ASYVM 346
Cdd:cd17371 227 GITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRI---GRRNNFALFALGSAISI--LLYFFLpLSPTL 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 347 QATCFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLAGWPLAKVLDTWHWSGFFVVISIAAGISALL 426
Cdd:cd17371 302 ILILGFPLGFFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLV 381
|
....*
gi 90111632 427 LLPFL 431
Cdd:cd17371 382 LALLL 386
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
28-310 |
2.65e-09 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 57.90 E-value: 2.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 28 RRHILLTIWLGYALFYFTRKSFNAAVPEILANGVLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGI 107
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 108 INILFGFSTSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAAAALHYGWRAGM 187
Cdd:COG0477 92 ASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 188 MIAGCMAIVVGIFLCWRLRDRPQALGLPAVGEWRHDALEIAQQQEGAGLTRKEILTKYVLLNPYIWLLSFCYVLVYVVRA 267
Cdd:COG0477 172 LINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALL 251
|
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 90111632 268 AINDWGNLYMSETLGVDLVTANTAVTMFELGGFIGALVAGWGS 310
Cdd:COG0477 252 LLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALL 294
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
1-205 |
3.00e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 58.35 E-value: 3.00e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 1 MLPFLKAPADAPLMTDKYEIDARYRYWRRHILLTIWLGYALFYFTRKSFNAAVPEILANG-VLSRSDIGLLATLFYITYG 79
Cdd:cd17474 169 ILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLyGISPIIIGLLFAGWSVLLA 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 80 VSKFVSG-IVSDRSNARYFMGIGLIATGIINILFGFSTSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWAL 158
Cdd:cd17474 249 LGSLFVGrLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSL 328
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 90111632 159 WNTAHNVGGALIPIVMAAAALHYGWRAgMMIAGCMAIVVGIFLCWRL 205
Cdd:cd17474 329 YNFVRFLGQAVGPLLFGLLLEIFGLSA-PFLVGAAIALAAAVLLALL 374
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
35-430 |
3.70e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 57.99 E-value: 3.70e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 35 IWLGYALFYFTRKSFNAAVPEILANGVLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGF 114
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 115 STSLWAFAVLWVLNAFfqGWG-SPVCARLLTAWYS----RTERGGWWALWNTAHNVGGALIPIVMAAaalHYGWRAGMMI 189
Cdd:cd17489 81 ATSVALLLVLRLIHGI--GWGaFTTAAATLVADIIppsrRGEGIGYYGLATTLAMALGPALGLFLYQ---HLGFAVLFIV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 190 AGCMAiVVGIFLCWRLRDRPQAlglpavgewrhdaleiaqqqeGAGLTRKEILTKYVLLNPYIWLLSFCYVLVYVVRAAI 269
Cdd:cd17489 156 AAVLA-LLALLLVFLVKDPPPV---------------------AAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAI 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 270 NDWGNLYMSETLgvdLVTANTAVTMFELGGFIGALVAGWGSDKlfngnRGPMNLIFAAGILLSVG--SLWLMPFASYVMQ 347
Cdd:cd17489 214 STFLPLYAAERG---ISNAGLFFTVYAIALLLSRPFSGKLSDR-----KGPKTVIIPGLLLLALGllLLSFAGSPWMLLL 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 348 ATCFFTIGFFVFGPqmLIGMAAAECSHKEAAGAATGFVGLFAYLGASLAGWPLAKVLDTWHWSGFFvvisIAAGISALLL 427
Cdd:cd17489 286 AAVLYGLGFGLLFP--ALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMF----LLAAVVVLLA 359
|
...
gi 90111632 428 LPF 430
Cdd:cd17489 360 LVL 362
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
52-400 |
3.87e-09 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 58.14 E-value: 3.87e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 52 AVPEILANGVLSRSDIGLL--ATLFYITYGvsKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSTSLWAFAVLWVLNA 129
Cdd:TIGR00895 39 AAPAISAEWGLDPVQLGFLfsAGLIGMAFG--ALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAG 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 130 FFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAAAALHYGWRAGMMIAGCMAIVVGIFLCWRL---- 205
Cdd:TIGR00895 117 LGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLpesi 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 206 -----------RDRPQALGLPAVGEWRHDALEIAQQQEGAGLTRKEILT-KYVLLNPYIWLLSFCYVLVYVvraAINDWG 273
Cdd:TIGR00895 197 dflvskrpetvRRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVFKALFQgKTARITVLLWLLYFMLLVGVY---FLTNWL 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 274 NLYMSETlGVDLVTANTAVTMFELGGFIGALVAGWGSDKLfngNRGPMNLIF-AAGILLSVGSLwlmPFASYVMQATCFF 352
Cdd:TIGR00895 274 PKLMVEL-GFSLSLAATGGALFNFGGVIGSIIFGWLADRL---GPRVTALLLlLGAVFAVLVGS---TLFSPTLLLLLGA 346
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 90111632 353 TIGFFVFGPQmlIGMAAAECSHKEAAGAATGFVGLF------AYLGASLAGWPL 400
Cdd:TIGR00895 347 IAGFFVNGGQ--SGLYALMALFYPTAIRATGVGWAIgigrlgAIIGPILAGYLL 398
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
36-393 |
4.60e-09 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 58.03 E-value: 4.60e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 36 WLGYALFYFTRKSFNAAVPEILANGVLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFS 115
Cdd:cd17341 5 WLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 116 -TSLWAFAVLwvlnAFFQGWGS---PVCARLLTAWYSRTERGGWWALWNTAHNVGGALI----PIVMAAAAL---HYGWR 184
Cdd:cd17341 85 vSSYWGLLVL----GFLLGFAGanfASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSqllaPLIAGAIVFdggFVGWR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 185 AGMMIAGCMAIVVGIFLCWRLRDRPQALglpavgewrhdaleiaqqqEGAGLTRKEIltKYVLLNPYIWLLSFCYVLVYV 264
Cdd:cd17341 161 NAFFVPGILLAIAAVLVLLFGDDLPTGK-------------------ASALEFLKVQ--LAVLKNYRTWILSLLYGVTFG 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 265 VRAAINDWGNLYMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLFNGNRGPMNLIFAAGILLSVGSLWLMPFASY 344
Cdd:cd17341 220 SFVGFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNL 299
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 90111632 345 VMQATCFFTIGFFV-FGPQMLIGMAAAEcsHKEAAGAATGFVGLFAYLGA 393
Cdd:cd17341 300 VLFLALFVALGLGAgAGNGSVFRMVPFI--FRRELGAVTGLVGAIGGLGG 347
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
2-204 |
1.26e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 56.47 E-value: 1.26e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 2 LPFLKAPADAPLMTDKYEIDARYRYWRRHILLTIWLGYALFYFTRKSFNAAVPEILA-NGVLSRSDIGLLATLFYITYGV 80
Cdd:cd06173 180 RPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKeVLGGGAAGYGLLLAAFGVGALL 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 81 SKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSTSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWN 160
Cdd:cd06173 260 GALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYN 339
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 90111632 161 TAHNVGGALIPIVMAAAALHYGWRAGMMIAGCMAIVVGIFLCWR 204
Cdd:cd06173 340 ALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
62-430 |
1.43e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 56.45 E-value: 1.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 62 LSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARY-----FMGIGLIATGIINILFGFSTSL-------WAFAVLWVLNA 129
Cdd:COG2211 43 LSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpWILIGAIPLALSFVLLFTAPDLsptgkliYALVTYLLLGL 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 130 FFQGWGSPVCARL--LTAwySRTERGGWWALWNTAHNVGGALIPIVMAAAALHY------GWRAGMMIAGCMAIVVGIFL 201
Cdd:COG2211 123 AYTLVNIPYSALGaeLTP--DYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLT 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 202 CWRLRDRPQAlglpavgewrhdaleiaqqqEGAGLTRKEILtKYVLLNPYIWLLSFCYVLVYVVRAAINDWGNLYMSETL 281
Cdd:COG2211 201 FFGTKERPVP--------------------EEEKVSLKESL-KALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 282 GVDLVTANTAVTMFELGGFIGALVAGWGSDKLfngnrGPMNLIFAAGILLSVGSL--WLMPFASYVMQATCFFTIGFFVF 359
Cdd:COG2211 260 GLSAALVGLLLALYFLAALLGAPLWPRLAKRF-----GKKKAFIIGLLLAALGLLllFFLGPGNLWLLLVLAALAGIGLG 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 360 GPQMLIGMAAAEC-------SHKEAAGAATGFVGLFAYLGASLAGWPLAKVLD---------------TWHWSGFFVVIS 417
Cdd:COG2211 335 AILVLPWAMLADVvdydewkTGRRREGLYFGIFTFAIKLGQALAGALAGLLLAlfgyvagaaqspsalTGIRLLFFLLPA 414
|
410
....*....|...
gi 90111632 418 IAAGISALLLLPF 430
Cdd:COG2211 415 VLLLLAALLLLFY 427
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
62-398 |
1.95e-08 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 55.79 E-value: 1.95e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 62 LSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSTSLWAFAVLWVLNAFFQGWGSPVCAR 141
Cdd:cd17333 28 LNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANT 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 142 LLTAWYSRTeRGGWWALWNTAHNVGGALIPIVMAAA-ALHYGWRAGMMIAGcmAIVVGIFLCWrlrdrpqalgLPAVGEW 220
Cdd:cd17333 108 FVGALFEES-SATRLNVLHGFFGLGALIGPLIATSLlTSELSWSWAYLIIG--LIYLLLAILI----------LLTLFPE 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 221 RHDALEIAQQQegaglTRKEILTKYVLLNPYIWLLSFCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVTMFELGGF 300
Cdd:cd17333 175 LPSARNPQQSV-----GAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGIT 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 301 IGALVAGWGSDKLfngnrGPMNLIFAAGILLSVGSLWLMPFASYVMQATCFFTIGFFVfGPQMLIGMAAAECSHKEAAGA 380
Cdd:cd17333 250 IGRLLGGPISRRI-----KPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFM-AALFPTILSLGISNLPYAKGK 323
|
330
....*....|....*...
gi 90111632 381 ATGFVGLFAYLGASLAGW 398
Cdd:cd17333 324 GTSVLLAAGSIGGAIIPF 341
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
63-430 |
9.56e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 50.69 E-value: 9.56e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 63 SRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFM-----GIGLIATGIINILFGFSTSLWAFAVLWVLNAFFQGWGSP 137
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLiladlLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 138 VCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAAAALHYGWRAGMMIAGCMAIVVGIFLCWrlrdrpqalglpav 217
Cdd:cd06173 112 ARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLF-------------- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 218 geWRHDALEIAQQQEGAGLTRKEILTKYVLLNPYIWLLSFCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVTMFEL 297
Cdd:cd06173 178 --IRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGV 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 298 GGFIGALVAGWGSDKLfngnrgPMNLIFAAGILLSVGSLWLMPFASYVMQATCFFTIGFFVFGPQMLIGMAAA-ECSHKE 376
Cdd:cd06173 256 GALLGALLLGRLSKRR------RRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLqLRVPDE 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 90111632 377 AAGAATGFVGLFAYLGASLAGWPLAKVLDTWHWSGFFVVISIAAGISALLLLPF 430
Cdd:cd06173 330 LRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
52-428 |
1.04e-06 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 50.65 E-value: 1.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 52 AVPEILANGVLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSTSLWAFAVLwvlnAFF 131
Cdd:cd17474 21 ILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAG----RAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 132 QGWGS----PVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAAAALHyGWRAGMMIAGCMAIVvgIFLCWRLRD 207
Cdd:cd17474 97 QGIGAaglgPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFLLAALIPV--AFLAILFLL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 208 RPQALGLPAVGEWRHDALEIAqqqegagLTRKEILTKYVLlnpyIWLLSFCY--VLVYVvraaindwgNLYMSETLGVDL 285
Cdd:cd17474 174 PEPKEKAKSSSATKLRDLKKA-------LRGRGLLTFLVS----AFLYFFLYfaFLTYL---------PFLLELLYGISP 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 286 VTANTAVTMFELGGFIGALVAGWGSDKLFngnrGPMNLIFAAGILLSVGSLWLMPFASYVMQATCFFTIGFFVFGPQMLI 365
Cdd:cd17474 234 IIIGLLFAGWSVLLALGSLFVGRLLKKRF----GARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLL 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 90111632 366 GMAAAECSHKEAAGAATGFVGLFAYLGASLAGWPLAKVLDTWHWSGFFVVISIAAGISALLLL 428
Cdd:cd17474 310 TTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLA 372
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
255-428 |
1.51e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 49.72 E-value: 1.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 255 LSFCYVLVYVVRAAINDWGNLYMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLfngnrGPMNLIFAAGILLSVG 334
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF-----GRRRVLLIGLLLFALG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 335 SLWLMPFASYVMQATCFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLAGWPLAKVLDTWHWSGFFV 414
Cdd:pfam07690 76 LLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFL 155
|
170
....*....|....
gi 90111632 415 VISIAAGISALLLL 428
Cdd:pfam07690 156 ILAILSLLAAVLLL 169
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
276-439 |
9.95e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 47.28 E-value: 9.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 276 YMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLfngnrGPMNLIFAAGILLSVGSLWLMPFASYVMQATCFFTIG 355
Cdd:COG2814 35 LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF-----GRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 356 FFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLAGWPLAKVLDTWHWSGFFVVISIAAGISALLLLPFLNAQT 435
Cdd:COG2814 110 LGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESR 189
|
....
gi 90111632 436 PREA 439
Cdd:COG2814 190 PAAR 193
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
292-428 |
1.24e-05 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 47.27 E-value: 1.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 292 VTMFELGGFIGALVAGWGSDKLfnGNRGPM---NLIFAAGILLSVGSLWLmpfASYVMQATCFFTIGFFVFGPQMLIGMA 368
Cdd:pfam00083 52 VSIFSVGCFIGSLFAGKLGDRF--GRKKSLliaNVLFVIGAVLQGAAKGK---WSVYQLIVGRVLVGIGVGGASVLAPMY 126
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 90111632 369 AAECSHKEAAGAATGFVGLFAYLG---ASLAGWPLAKVLDTWHWSGFFVVISIAAGISALLLL 428
Cdd:pfam00083 127 ISEIAPKKLRGALGSLYQLAITFGillAYIFGLGLNKTSNSDGWRIPLGLQLVPALLLIIGLL 189
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
253-439 |
9.90e-05 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 44.48 E-value: 9.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 253 WLLSFCYVLVYVV-RAAINDWGNL--YMSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLfngnrGPMNLIFAAGI 329
Cdd:COG2807 17 WLLLLAIVLVALNlRPAITSVGPLlpEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRF-----GLERTLLLALL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 330 LLSVGSLWLMPFASYVMQATCFFTIGF-FVFGPQMLIGMAAAECSHKeaAGAATGFVGLFAYLGASLAGWPLAKVLDTWH 408
Cdd:COG2807 92 LLAAGLLLRSLAPSVALLLAGTALIGAgIAVGNVLLPGLIKRWFPDR--VGLMTGLYTAAMGLGAALAAGLTVPLAAALG 169
|
170 180 190
....*....|....*....|....*....|.
gi 90111632 409 WSGFFVVISIAAGISALLLLPFLNAQTPREA 439
Cdd:COG2807 170 WRGALAVWALLALLALLLWLPLLRRRPAAAA 200
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
36-393 |
2.69e-04 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 43.06 E-value: 2.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 36 WLGYALFYFTRKSFNAAVPEILANGV-LSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGF 114
Cdd:TIGR00886 7 WFGFFLSFLVWFAFSPLAVFLIKDDLgLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 115 ST-SLWAFAVLWVLnAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAAAALHYGWRAGM--MIAG 191
Cdd:TIGR00886 87 AVqSYSVLLLIRLF-IGIAGGSFASCMPWISFFFPKKIQGTALGLAAGWGNMGGGVAQFVMPPIIGSLIFGGGQpaHLAW 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 192 CMAIVVGIFLCWRLrdrpQALGLPAVGEWRhdaleIAQQQEGAGLTRKEilTKYVLLNPYIWLLSFCYVLVYVVRAAIND 271
Cdd:TIGR00886 166 GWAFVIVPAGILLL----PALLIFFVGADT-----PPGKPATGKLSFKE--ALKVFGNRHTWILALLYSVTFGSFLGVSS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 272 WGNLYMSETLGVDLVTANTAVTMFelgGFIGALV---AGWGSDKLFNGNRGPMNLIFAAG--ILLSVGSLWLMPFASYVM 346
Cdd:TIGR00886 235 IFAMLFKDQFGLSKVQAGAYASLG---GFLGSLArpaGGAISDRLGGARKLLMNFLGVAMgaFLVVLGLVSDGSLAAFIV 311
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 90111632 347 QATCFFTigFFVFGPQMLIGMAAAecSHKEAAGAATGFVGLFAYLGA 393
Cdd:TIGR00886 312 LFVALFF--FAGAGNGSTFALVPH--IFRRATGAVSGLIGAIGNLGG 354
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
67-428 |
4.35e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 42.18 E-value: 4.35e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 67 IGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSTSLWAFAVLWVLNAFFQGWGSPVCARLLTAW 146
Cdd:cd17473 37 VPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDY 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 147 YSRTERGGWWALWNTAHNVGGALIPIVMAAAALhYGWRAGMMIAGcMAIVVGIFLCWRLRDRPQAlglpavgewrhdale 226
Cdd:cd17473 117 FEGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYL-LALPVLILVLLFLPEPARK--------------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 227 iAQQQEGAGLTRKEILTKYVLLNPYIwLLSFCYVLVYVVRAAINdwgnLYMSETLGVDLVTANTAVTMFELGGFIGALVA 306
Cdd:cd17473 180 -SKSAASPGAATAAALPWKRVLPIYF-LAFLAMLLFYVIPIQLP----FLLQERGGGSAALIGLALAIASLAGAIGALLF 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 307 GWGSDKLfngnrGPMNLIFAAGILLSVG--SLWLMPFASYVMQATCFFTIGFFVFGPQMLIgmAAAECSHKEAAGAATGF 384
Cdd:cd17473 254 GRLKRRL-----GKRRLLAIGFALMALGflLLALASGLWVVLLGAILAGLGFGLLLPTLNS--WAMSLVPPELRGRAMGI 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 90111632 385 VGLFAYLGASLAGW---PLAKVLDTwhWSGFFVVISIAAGISALLLL 428
Cdd:cd17473 327 VTSAFFLGQFLSPLvlgPLVNLTGG--LSGAFLILGVLALVLAIVLL 371
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
68-203 |
5.40e-04 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 42.31 E-value: 5.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 68 GLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSTSLWAFAVLWVLNAFFQGWGSPVCARLLTAWY 147
Cdd:TIGR00898 130 DLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEFL 209
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 90111632 148 SRTERGGWWALWNTAHNVGGALIPIVmaaAALHYGWRAgMMIAGCMAIVVGIFLCW 203
Cdd:TIGR00898 210 PKKQRAIVGTLIQVFFSLGLVLLPLV---AYFIPDWRW-LQLAVSLPTFLFFLLSW 261
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
50-396 |
7.27e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 41.39 E-value: 7.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 50 NAAVPEILANGVLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSTSLWAFAVLWVLNA 129
Cdd:cd17321 16 NVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 130 FFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAAAALHYGWRAGMMIAGCMAIVVgiflcwrlrdrp 209
Cdd:cd17321 96 IGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVA------------ 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 210 qalglpavgewrhdaleiaqqqegagltrkeiltkyVLLNPYIWLLSFCYVLVYVVRAAINDWGNLYMSETLGVDLVTAN 289
Cdd:cd17321 164 ------------------------------------LLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAG 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 290 TAVTMFELGGFIGALVAGWGSDKLfngnrGPMNLIFAAGILLSVGSLWLMPF---ASYVMQATCFFTIGF---FVFGPQM 363
Cdd:cd17321 208 LALLPLALAMLVAAPLAGRLADRF-----GPRLVLVAGLLLTAVGLLLLALLgadSSVWLLLPGLVLLGLglgLFATPLT 282
|
330 340 350
....*....|....*....|....*....|...
gi 90111632 364 LIGMAAAEcshKEAAGAATGFVGLFAYLGASLA 396
Cdd:cd17321 283 NAALSSVP---KEKAGAASGILNTARQLGGALG 312
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
31-205 |
8.05e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 41.40 E-value: 8.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 31 ILLTIWLGYALFYftrkSFNAAVPEIL-ANGVLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIIN 109
Cdd:cd17473 202 IYFLAFLAMLLFY----VIPIQLPFLLqERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGF 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 110 ILFGFSTSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAAAALHYGWRAGM-M 188
Cdd:cd17473 278 LLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAfL 357
|
170
....*....|....*..
gi 90111632 189 IAGCMAIVVGIFLCWRL 205
Cdd:cd17473 358 ILGVLALVLAIVLLLLR 374
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
277-439 |
8.13e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 41.38 E-value: 8.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 277 MSETLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLfngNRGPMnliFAAGILLSVGSLWLMPFA-SYVMQATCFFTIG 355
Cdd:cd17324 25 IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRI---ERRRL---LLVLLLLFILGNLLAALApSFALLLLARALAG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 356 FFVFGPQMLIGMAAAECSHKEAAGAATGFVgLFAYLGASLAGWPLAKVL-DTWHWSGFFVVISIAAGISALLLLPFLNAQ 434
Cdd:cd17324 99 LAHGGFWAIAAAYAADLVPPEKRGRAIGLV-FSGLTLGLVLGRPLGGLLgQLLGWRAAFLAIAVLALLAALLLWRLLPSL 177
|
....*
gi 90111632 435 TPREA 439
Cdd:cd17324 178 PPKKP 182
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
43-201 |
1.08e-03 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 41.02 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 43 YFTRKSFNAAVPEILANGVLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSTSLWAFA 122
Cdd:cd17323 12 TFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLI 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 123 VLWVLNAFFqgwGSP---VCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAAAALHYGWRA----GMMIAGCMAI 195
Cdd:cd17323 92 ILRFLQGFF---GSSplaIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWifwfLAIISGFCLI 168
|
....*.
gi 90111632 196 VVGIFL 201
Cdd:cd17323 169 LIFLFL 174
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
26-203 |
1.19e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 40.66 E-value: 1.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 26 YWRRHILLtIWLGYALFYFTRKSFNAAVPEILANGV-LSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIA 104
Cdd:cd17316 174 LLRRRTLL-LILLWFFISFGYYGLTTFLPTYLQTVLgLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLIL 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 105 TGIINILFGF--STSLWAFAVLWVLNAFFQGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAAAALHYG 182
Cdd:cd17316 253 SGILALPLFYllSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTG 332
|
170 180
....*....|....*....|.
gi 90111632 183 WRAGMMIAGCMAIVVGIFLCW 203
Cdd:cd17316 333 GTGVPALILALLAIVALIVAL 353
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
165-370 |
1.36e-03 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 40.72 E-value: 1.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 165 VGGALIPIVMAAAALHYGWRAGMMIAGCMAIVVGIFLCWRLRDRPQALGLPAVGEWRHDALEIAQQQEGAGLTrkeiltk 244
Cdd:PRK11551 150 FGGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLPESRAFAQAAGAGKQRAPVLRALFGEGRATAT------- 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 245 yVLLnpyiWLLSFCYVLVyvVRAAINdWGNLYMSETlGVDLVTANTAVTMFELGGFIGALVAGWGSDKLfngNRGPMNLI 324
Cdd:PRK11551 223 -LLL----WISYFFTLIV--LYFLLN-WLPSLLVGQ-GLSRSQAGLVQIAFNIGGALGSLLIGALMDRL---RPRRVVLL 290
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 90111632 325 FAAGILLSVGSLWLMPfaSYVMQATCFFTIGFFVFGPQM-LIGMAAA 370
Cdd:PRK11551 291 IYAGILASLAALAAAP--SFAGMLLAGFAAGLFVVGGQSvLYALAPL 335
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
53-202 |
1.51e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 40.67 E-value: 1.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 53 VPEILANGVLSRSDIGLLATLFYITYGV-SKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSTSLWAFAVLWVLNAFF 131
Cdd:cd17490 218 TPLIAKQLGASSFQLGLLSIIYLLPNALaSLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFG 297
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 90111632 132 QGWGSPVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAAAALHYGWRAGMMIAGCMAIVVGIFLC 202
Cdd:cd17490 298 TGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSL 368
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
67-428 |
1.54e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 40.60 E-value: 1.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 67 IGLLATLFYITYGVSKFVSGIVSDRSNARY-FMGIGLIATGIINILFGFSTSLWAFAVLWVLNAFFQGWGSPVCARLLTA 145
Cdd:cd17370 36 VGLIEGLAEALGSLLRLFSGYLSDRTGKRKpLVILGYGLSALAKPLLALAGSWQLVLLLRILERLGKGIRTPPRDALLAD 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 146 WYSRTERGGWWALWNTAHNVGGALIPIVMAA--AALHYGWRAGMMIAGCMAIvVGIFLCWRLRDRPqalglpavgewrhd 223
Cdd:cd17370 116 ATPPSGRGKAFGLHRALDTLGAVLGPLLAALllYLLGGNYRTIFLLAAIPAL-LALLILLFVVKEY-------------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 224 aleiaqqQEGAGLTRKEILTKYVLLNPYIWLlsfcyvlvYVVRAAINDWGN------LYMSETLGVDLVTANTAVTMFEL 297
Cdd:cd17370 181 -------PRPPKLRKKSKKTSLKKLPKAFWL--------YLLAVALFALGNfsfaflILRAQELGLSAALIPLLYALFNL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 298 GGFIGALVAGWGSDKLfngnrGPMNLIFaAGILLSVGSLWLMPFASYVMqatcFFTIGFFVFGpqmlIGMAA-------- 369
Cdd:cd17370 246 VYALAAYPAGRLSDRI-----GRKKLLI-LGYLSLALAYLGFALGSSLW----LLLLGFILWG----LYMGAqesieraa 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 90111632 370 -AECSHKEAAGAATGF----VGLFAYLGASLAGWplakVLDTWHWSGFFVVISIAAGISALLLL 428
Cdd:cd17370 312 vADLVPAELRGTAYGLfntvVGIGWLLASLIAGY----LWDLISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
292-428 |
1.79e-03 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 40.25 E-value: 1.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 292 VTMFELGGFIGALVAGWGSDKLfngnrGPMNLIFAAGILLSVGSLwLMPFA-SYVMQATCFFTIGFFVFGPQMLIGMAAA 370
Cdd:cd17315 40 VSSLLLGAAIGSLFGGPLADRF-----GRRKSLLIAAVLYVIGAL-LSALApNVWVLIVGRFLLGLGVGLASVLVPLYIS 113
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 90111632 371 ECSHKEAAGAATGFVGLFAYLG---ASLAGWPLAKVLDTWhWSGFFVVISIAAGISALLLL 428
Cdd:cd17315 114 EIAPAKIRGALGTLNQLMITFGillAYLLGLALSLSPPGW-WRLMFALAAVPALLQLLLMF 173
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
62-201 |
2.80e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.83 E-value: 2.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 62 LSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSTSLWAFAVLWVL----NAFFQGWGSP 137
Cdd:cd17370 231 LSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILwglyMGAQESIERA 310
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 90111632 138 VCARLLtawySRTERGGWWALWNTAHNVGGALIPIVMAAAALHYGWRAGMMIAGCMAIVVGIFL 201
Cdd:cd17370 311 AVADLV----PAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLLL 370
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
255-432 |
3.45e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 39.33 E-value: 3.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 255 LSFCYVLVYVVRAAINDWGNLYMSEtLGVDLVTANTAVTMFELGGFIGALVAGWGSDKLfngnrGPMNLIFAAGILLSVG 334
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQS-FGLSASQLGLLFALFSLGYALLQPLAGLLADRF-----GRRPVLLLGLLLFALG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 335 SLWLMPFASYVMQATCFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGASLAGW--PLAKVLDTWHWSGF 412
Cdd:cd06174 75 ALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLlgGILASSLGFGWRAV 154
|
170 180
....*....|....*....|
gi 90111632 413 FVVISIAAGISALLLLPFLN 432
Cdd:cd06174 155 FLIAAALALLAAILLLLVVP 174
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
31-219 |
4.09e-03 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 39.21 E-value: 4.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 31 ILLTIWLGYALFYFTrksfnAAVPEILANGVLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINI 110
Cdd:cd06180 5 LALAVAMGIGRFAYT-----PLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 111 LFGFSTSLWAFAVLWVLNAFFQGWGSpVCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAAAALHYG--WRAGMM 188
Cdd:cd06180 80 AMALTSGFAALLALRFLAGAASAFVF-VFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGGlsWRAGWL 158
|
170 180 190
....*....|....*....|....*....|.
gi 90111632 189 IAGCMAIVVGIFLCWRLRDRPQALGLPAVGE 219
Cdd:cd06180 159 ALALLSAVLLLLSFLLLRRGPSAPTEASAAE 189
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
52-187 |
4.14e-03 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 39.52 E-value: 4.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 52 AVPEILANGVLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSTSLWAFAVLWVLNAFF 131
Cdd:cd17438 21 VLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAFLFCRLISGFG 100
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 90111632 132 QGWGSPVCARLLTAWYSRTERGGWWAlWNTAHNVGGALIPIVMAAAAL-HYGWRAGM 187
Cdd:cd17438 101 IGGSLPIVFAYFSEFLAREKRGEHLS-WLCMFWMIGGLYASAMAWSIIpHYGWGFSM 156
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
49-427 |
5.20e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 38.69 E-value: 5.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 49 FNAAVPEILANGVLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSTSLWafavLWVLN 128
Cdd:cd17477 15 LLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPW----VWFLL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 129 AFFQGWGSP----VCARLLTAWYSRTERGGWWALWNTAHNVGGALIPIVMAAAAlHYGWRAGMMIAGCMAIVVgIFLCWR 204
Cdd:cd17477 91 RFVMGIGLAglfvVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVG-TAGALPFLIAAVLLLLAL-VPLLLT 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 205 LRDRPQALGLPAVGEWRhdaleiaqqqegagltrkeiltkYVLLNPyiwlLSFCYVLVY-VVRAAINDWGNLYMSEtLGV 283
Cdd:cd17477 169 RRAAPEIEEAESISLRR-----------------------LLRIAP----LALLGAFVAgFLEGAFYSLLPLYGLR-LGL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 284 DLVTANTAVTMFELGGFIGALVAGWGSDKLfngnrGPMNLIFAAGILLSVGSLWLMPFASY-VMQATCFFTIGFFVFGPQ 362
Cdd:cd17477 221 SVAQAALLLAAFVLGGLLLQWPLGWLADRF-----DRRRVLLGCALLGALAALLLPLVPGLpLALLVLLFLWGGAAGPLY 295
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 90111632 363 ML-IGMAAAECSHKEAAGAATGFvgLFAYLGASLAGWPLAKVLDTWHWS-GFFVVISIAAGISALLL 427
Cdd:cd17477 296 TLaLALAGDRLPGDELVAANAAL--LLLYGLGSVIGPLLAGALMDAFGPhGLFLFLAAVALLFLLFL 360
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
68-183 |
6.38e-03 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 38.75 E-value: 6.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 68 GLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFST--SLWAFAVLWVLNAFFQGWGSPVCARLLTA 145
Cdd:cd17318 59 GIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAArgGYGALIVLRILQGLAQGVTFPAMHALWAK 138
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 90111632 146 WYSRTERGGWWALWNTAHNVGGAlipIVMAAAAL---HYGW 183
Cdd:cd17318 139 WAPPLERSRLTSIAYSGSQFGTV---IAMPLSGFlceSLGW 176
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
67-397 |
6.92e-03 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 38.44 E-value: 6.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 67 IGLLATLFYITYGVSKFVSGIVSDRSNARY-----FMGIGLIATGIINILF------GFSTSL-WAFAVLWVLNAFFQGW 134
Cdd:pfam13347 35 VGLVLLVARLVDAFTDPIVGHIIDRTRTRWgrrrpWLLLSAIILAVSFILLftppelGRAPLFiWLLATYILLRIAYTFF 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 135 GSPVCARLLTAWYSRTER---GGWWALWNTAHNVGGALIPIVMAAAALHY-----GWRAGMMIAGCMAIVVGIFLCWRLR 206
Cdd:pfam13347 115 EIPYWSLGPELTRDYDERtslTSYRSFFSVGGGLLAAALAFPLVLILGGTglerkGYRIFALIGAVLMLLGVIITAAGTK 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 207 DRPQALGLPAvgEWRHDALEIAQQqegagltrkeilTKYVLLNPYIWLLSFCYVLVYVVRAAINDWGNLYMSETLGvDLV 286
Cdd:pfam13347 195 ERVSMRSKED--TGQKEAGSLLDM------------LKEVFRNRAFLILLASFLLAALAMGVLNGLLLYYFRYVLG-NGF 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 287 TANTAVTMFELGGFIGALVAGWGSDKLfnGNRGPMNLIFAAGILLSVGSLWLMPFAS---YVMQATCFFTIGFFVFGPQM 363
Cdd:pfam13347 260 AASAFPLVFTIGALLGIPLWPPLAKRI--GKKNTYILGALITIAGFALALLLGPNNTllfLVLYIIIGFGYGSSFFLPWS 337
|
330 340 350
....*....|....*....|....*....|....*..
gi 90111632 364 LIGMAAAEC---SHKEAAGAATGFVGLFAYLGASLAG 397
Cdd:pfam13347 338 MLADVVDYGelrTGKRREGTFFAMWSFISKLATGVGL 374
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
62-211 |
7.28e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 38.30 E-value: 7.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111632 62 LSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSTSLWAFAVLWVLNAFFQGWGSPVC-A 140
Cdd:COG0738 243 LSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIfS 322
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 90111632 141 RLLTAWYSRTERGGwwALWNTAHNVGGALIPIVMAAAALHYGWRAGMMIAGCMAIVVGIFLCWRLRDRPQA 211
Cdd:COG0738 323 LALDGLGKRTAAAV--SAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
|
|
| |
