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Conserved domains on  [gi|16131765|ref|NP_418362|]
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glycerol facilitator [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 10001739)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  11964478|8849412|11473620
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 6-256 2.53e-90

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


:

Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 267.38  E-value: 2.53e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765   6 TLKGQCIAEFLGTGLLIFFGVGCVAALKVAGASFGQWEISVIWGLGVAMAIYLTAGVSGAHLNPAVTIALWLFACFDKRK 85
Cdd:COG0580   1 SLMKRLLAEFLGTFILVLLGCGVVAVLAGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765  86 VIPFIVSQVAGAFCAAALVYGLYYNLFFDFEqthhivrgsvESVDLAGTFSTYPNPHINFVQAFAVEMVITAILMGLILA 165
Cdd:COG0580  81 VLPYIIAQLLGAFLGAALVYLIYGGHFDATE----------DGGAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILG 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765 166 LTDDGNgvPRGPLAPLLIGLLIAVIGASMGPLTGFAMNPARDFGPKVFAWLagwgnvaFTGGRDIPYFLVPLFGPIVGAI 245
Cdd:COG0580 151 ITDKRA--APGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHAL-------GKGGSDWGYLWVPIVAPILGAA 221

                       250
                ....*....|.
gi 16131765 246 VGAFAYRKLIG 256
Cdd:COG0580 222 LAALLYRALFG 232
 
Name Accession Description Interval E-value
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 6-256 2.53e-90

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 267.38  E-value: 2.53e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765   6 TLKGQCIAEFLGTGLLIFFGVGCVAALKVAGASFGQWEISVIWGLGVAMAIYLTAGVSGAHLNPAVTIALWLFACFDKRK 85
Cdd:COG0580   1 SLMKRLLAEFLGTFILVLLGCGVVAVLAGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765  86 VIPFIVSQVAGAFCAAALVYGLYYNLFFDFEqthhivrgsvESVDLAGTFSTYPNPHINFVQAFAVEMVITAILMGLILA 165
Cdd:COG0580  81 VLPYIIAQLLGAFLGAALVYLIYGGHFDATE----------DGGAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILG 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765 166 LTDDGNgvPRGPLAPLLIGLLIAVIGASMGPLTGFAMNPARDFGPKVFAWLagwgnvaFTGGRDIPYFLVPLFGPIVGAI 245
Cdd:COG0580 151 ITDKRA--APGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHAL-------GKGGSDWGYLWVPIVAPILGAA 221

                       250
                ....*....|.
gi 16131765 246 VGAFAYRKLIG 256
Cdd:COG0580 222 LAALLYRALFG 232
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 10-254 1.81e-85

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 254.87  E-value: 1.81e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765  10 QCIAEFLGTGLLIFFGVGCVAALKVAG-ASFGQWEISVIWGLGVAMAIYLTAGVSGAHLNPAVTIALWLFACFDKRKVIP 88
Cdd:cd00333   2 KYLAEFLGTFLLVFFGCGSVLAVKLAGgASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVIP 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765  89 FIVSQVAGAFCAAALVYGLYYNLFFDFEQTHHIVrgsvesvdlAGTFSTYPNPHINFVQAFAVEMVITAILMGLILALTD 168
Cdd:cd00333  82 YIIAQLLGAILGAALLYGLYYGLYLEFLGANNIV---------AGIFGTYPSPGVSNGNAFFVEFIGTFILVLVVFATTD 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765 169 DGNGVPRGPLAPLLIGLLIAVIGASMGPLTGFAMNPARDFGPKVFAWLAgwgnvaftggRDIPYFLVPLFGPIVGAIVGA 248
Cdd:cd00333 153 DPNGPPPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLA----------RHWHYFWVYWVGPLIGAIAGA 222


                ....*.
gi 16131765 249 FAYRKL 254
Cdd:cd00333 223 LVYDYV 228
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 1-251 5.44e-77

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 233.36  E-value: 5.44e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765     1 MSQTSTLKGQCIAEFLGTGLLIFFGVGCVAALKVAGASFG--QWEISVI-WGLGVAMAIYLTAGVSGAHLNPAVTIALWL 77
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSLAvsGLLAVALaFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765    78 FACFDKRKVIPFIVSQVAGAFCAAALVYGLYYNLffdfeqthhivrgsvesvDLAGTFSTYPNPHINFVQAFAVEMVITA 157
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGL------------------QRAGLFANTLAPGVNAGQAFVVEIILTF 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765   158 ILMGLILALTDDGNGVPRGPLAPLLIGLLIAVIGASMGPLTGFAMNPARDFGPKVFAWlagwgnvaftggrDIPYFLVPL 237
Cdd:pfam00230 143 QLVYCVFATTDDRRNGSLGTVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLW-------------KWDDHWVYW 209

                         250
                  ....*....|....
gi 16131765   238 FGPIVGAIVGAFAY 251
Cdd:pfam00230 210 VGPFIGAALGALVY 223
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 13-251 5.44e-68

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 210.23  E-value: 5.44e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765    13 AEFLGTGLLIFFGVGCVAALKVAG-----ASFGQWEISVIWGLGVAMAIYLTAGVSGAHLNPAVTIALWLFACFDKRKVI 87
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGaygavGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765    88 PFIVSQVAGAFCAAALVYGLYYNLFfdfEQTHHIVRGsvesvdlagtfstyPNPHINFVQAFAVEMVITAILMGLILALT 167
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLF---PGNLAVNGS--------------ASAGVSSGQAFFVEFIGTAILVLVIFATT 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765   168 DDGNGVPRGPLAPLLIGLLIAVIGASMGPLTGFAMNPARDFGPKVFAWLAGWGNvaftggrdipyFLVPLFGPIVGAIVG 247
Cdd:TIGR00861 144 DDRNRVPRGGFAPLAIGLLVFLIHLSMGPYTGTGMNPARSLGPALFAGLAGWGN-----------HWVYWVGPIIGAILG 212


                  ....
gi 16131765   248 AFAY 251
Cdd:TIGR00861 213 ALVY 216
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 10-256 9.67e-65

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 204.59  E-value: 9.67e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765   10 QCIAEFLGTGLLIFFGVGCVAALKVAGASFGQWEISVIWGLGVAMAIYLTAGVSGAHLNPAVTIALWLFACFDKRKVIPF 89
Cdd:PTZ00016  52 EYVAEFLGTFVLLFFGEGVVATTHTVGNNGDYLAITIGWGLGVTFGLLVSAGISGGHLNPAVTLGNAVFGKFPWKKLPGY 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765   90 IVSQVAGAFCAAALVYGLYYNLFFDFEQTHHIVRGSVESVdlAGTFSTYPNphINFVQAFAVEMVITAILMGLILALTDD 169
Cdd:PTZ00016 132 FVAQLLGAFVGAACVYGLYYGFFKDHGIPELPWETMANGF--AGVFATYPR--EGNFYAIFSELILTAILLLVILAITDP 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765  170 GNGVPRGPLaPLLIGLLIAVIGASMGPLTGFAMNPARDFGPKVFAWLAgWGNVAFTggRDIPYFLVPLFGPIVGAIVGAF 249
Cdd:PTZ00016 208 NNCPAFNYL-PVAVGLLVFVIGISFGGNTGYALNPARDLGPRLFSAIL-WGSEVFT--KDNYYFWVPLVAPFVGAVLGMF 283


                 ....*..
gi 16131765  250 AYRKLIG 256
Cdd:PTZ00016 284 LYDKFIP 290
 
Name Accession Description Interval E-value
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 6-256 2.53e-90

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 267.38  E-value: 2.53e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765   6 TLKGQCIAEFLGTGLLIFFGVGCVAALKVAGASFGQWEISVIWGLGVAMAIYLTAGVSGAHLNPAVTIALWLFACFDKRK 85
Cdd:COG0580   1 SLMKRLLAEFLGTFILVLLGCGVVAVLAGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765  86 VIPFIVSQVAGAFCAAALVYGLYYNLFFDFEqthhivrgsvESVDLAGTFSTYPNPHINFVQAFAVEMVITAILMGLILA 165
Cdd:COG0580  81 VLPYIIAQLLGAFLGAALVYLIYGGHFDATE----------DGGAKLGVFATSPAIGYSLGAAFLTEIIGTFVLVFVILG 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765 166 LTDDGNgvPRGPLAPLLIGLLIAVIGASMGPLTGFAMNPARDFGPKVFAWLagwgnvaFTGGRDIPYFLVPLFGPIVGAI 245
Cdd:COG0580 151 ITDKRA--APGGLAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHAL-------GKGGSDWGYLWVPIVAPILGAA 221

                       250
                ....*....|.
gi 16131765 246 VGAFAYRKLIG 256
Cdd:COG0580 222 LAALLYRALFG 232
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 10-254 1.81e-85

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 254.87  E-value: 1.81e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765  10 QCIAEFLGTGLLIFFGVGCVAALKVAG-ASFGQWEISVIWGLGVAMAIYLTAGVSGAHLNPAVTIALWLFACFDKRKVIP 88
Cdd:cd00333   2 KYLAEFLGTFLLVFFGCGSVLAVKLAGgASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVIP 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765  89 FIVSQVAGAFCAAALVYGLYYNLFFDFEQTHHIVrgsvesvdlAGTFSTYPNPHINFVQAFAVEMVITAILMGLILALTD 168
Cdd:cd00333  82 YIIAQLLGAILGAALLYGLYYGLYLEFLGANNIV---------AGIFGTYPSPGVSNGNAFFVEFIGTFILVLVVFATTD 152

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765 169 DGNGVPRGPLAPLLIGLLIAVIGASMGPLTGFAMNPARDFGPKVFAWLAgwgnvaftggRDIPYFLVPLFGPIVGAIVGA 248
Cdd:cd00333 153 DPNGPPPGGLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLA----------RHWHYFWVYWVGPLIGAIAGA 222


                ....*.
gi 16131765 249 FAYRKL 254
Cdd:cd00333 223 LVYDYV 228
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 1-251 5.44e-77

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 233.36  E-value: 5.44e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765     1 MSQTSTLKGQCIAEFLGTGLLIFFGVGCVAALKVAGASFG--QWEISVI-WGLGVAMAIYLTAGVSGAHLNPAVTIALWL 77
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSSLAvsGLLAVALaFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765    78 FACFDKRKVIPFIVSQVAGAFCAAALVYGLYYNLffdfeqthhivrgsvesvDLAGTFSTYPNPHINFVQAFAVEMVITA 157
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGL------------------QRAGLFANTLAPGVNAGQAFVVEIILTF 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765   158 ILMGLILALTDDGNGVPRGPLAPLLIGLLIAVIGASMGPLTGFAMNPARDFGPKVFAWlagwgnvaftggrDIPYFLVPL 237
Cdd:pfam00230 143 QLVYCVFATTDDRRNGSLGTVAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLW-------------KWDDHWVYW 209

                         250
                  ....*....|....
gi 16131765   238 FGPIVGAIVGAFAY 251
Cdd:pfam00230 210 VGPFIGAALGALVY 223
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 13-251 5.44e-68

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 210.23  E-value: 5.44e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765    13 AEFLGTGLLIFFGVGCVAALKVAG-----ASFGQWEISVIWGLGVAMAIYLTAGVSGAHLNPAVTIALWLFACFDKRKVI 87
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALGVNVAGaygavGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765    88 PFIVSQVAGAFCAAALVYGLYYNLFfdfEQTHHIVRGsvesvdlagtfstyPNPHINFVQAFAVEMVITAILMGLILALT 167
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLF---PGNLAVNGS--------------ASAGVSSGQAFFVEFIGTAILVLVIFATT 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765   168 DDGNGVPRGPLAPLLIGLLIAVIGASMGPLTGFAMNPARDFGPKVFAWLAGWGNvaftggrdipyFLVPLFGPIVGAIVG 247
Cdd:TIGR00861 144 DDRNRVPRGGFAPLAIGLLVFLIHLSMGPYTGTGMNPARSLGPALFAGLAGWGN-----------HWVYWVGPIIGAILG 212


                  ....
gi 16131765   248 AFAY 251
Cdd:TIGR00861 213 ALVY 216
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 10-256 9.67e-65

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 204.59  E-value: 9.67e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765   10 QCIAEFLGTGLLIFFGVGCVAALKVAGASFGQWEISVIWGLGVAMAIYLTAGVSGAHLNPAVTIALWLFACFDKRKVIPF 89
Cdd:PTZ00016  52 EYVAEFLGTFVLLFFGEGVVATTHTVGNNGDYLAITIGWGLGVTFGLLVSAGISGGHLNPAVTLGNAVFGKFPWKKLPGY 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765   90 IVSQVAGAFCAAALVYGLYYNLFFDFEQTHHIVRGSVESVdlAGTFSTYPNphINFVQAFAVEMVITAILMGLILALTDD 169
Cdd:PTZ00016 132 FVAQLLGAFVGAACVYGLYYGFFKDHGIPELPWETMANGF--AGVFATYPR--EGNFYAIFSELILTAILLLVILAITDP 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765  170 GNGVPRGPLaPLLIGLLIAVIGASMGPLTGFAMNPARDFGPKVFAWLAgWGNVAFTggRDIPYFLVPLFGPIVGAIVGAF 249
Cdd:PTZ00016 208 NNCPAFNYL-PVAVGLLVFVIGISFGGNTGYALNPARDLGPRLFSAIL-WGSEVFT--KDNYYFWVPLVAPFVGAVLGMF 283


                 ....*..
gi 16131765  250 AYRKLIG 256
Cdd:PTZ00016 284 LYDKFIP 290
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 12-261 1.09e-27

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 107.64  E-value: 1.09e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765   12 IAEFLGTGLLIFFGVGCVAALKVAGASFGQWEISVIWGLGVAMAIYLTAGVSGAHLNPAVTIALWLFACFDKRKVIPFIV 91
Cdd:PLN00183  49 LAEMVGTFILMFCVCGIIASTQLSGGEVGLLEYAATAGLTVVVVVFSIGSISGAHVNPSVTIAFATFGHFPWSKVPLYIT 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765   92 SQVAGAFCA---AALVYGLyynlffdfeqthhivrgsveSVDLAGTfstypNPHINFVQAFAVEMVITAILMGLILALTD 168
Cdd:PLN00183 129 AQTVGSVLAtyvGVSVYGV--------------------KADLMTT-----KPAQGCSSAFWVEFIATFIVMFLAASLTS 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765  169 DGNGVprGPLAPLLIGLLIAVIGASMGPLTGFAMNPARDFGPKVFAWlagwgnvaftggrDIPYFLVPLFGPIVGAIVGA 248
Cdd:PLN00183 184 QPQSL--GHLSGFVIGIAIGLAVLITGPVSGGSMNPARSLGPAIVSW-------------DFKDIWIYITAPTIGAVAGA 248

                        250
                 ....*....|...
gi 16131765  249 FAYRKLIGRHLPC 261
Cdd:PLN00183 249 LMFHLLRLRTQPC 261
PLN00184 PLN00184
aquaporin NIP1; Provisional
 12-251 6.35e-24

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 98.17  E-value: 6.35e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765   12 IAEFLGTGLLIFFGVGCVAALKVAGASFGQWEISVIWGLGVAMAIYLTAGVSGAHLNPAVTIALWLFACFDKRKVIPFIV 91
Cdd:PLN00184  58 IAEVLGTYFLVFTGCASVVVNMQNDNVVTLPGIAIVWGLTIMVLIYSLGHISGAHINPAVTIAFASCGRFPLKQVPAYVI 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765   92 SQVAGAFCAAA---LVYGLYYNLffdFEQTHHIVRGSVesvdlagtfstypnPHINFVQAFAVEMVITAILMGLILALTD 168
Cdd:PLN00184 138 SQVIGSTLAAAtlrLLFGLDHDV---CSGKHDVFIGSS--------------PVGSDLQAFVMEFIVTFYLMFIISGVAT 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765  169 DGNGVprGPLAPLLIG--LLIAVIGAsmGPLTGFAMNPARDFGPKvfawlagwgnVAFTGGRDIPYFLVplfGPIVGAIV 246
Cdd:PLN00184 201 DNRAI--GELAGLAIGstVLLNVLIA--APVSSASMNPGRSLGPA----------MVYGCYKGIWIYIV---APTLGAIA 263


                 ....*
gi 16131765  247 GAFAY 251
Cdd:PLN00184 264 GAWVY 268
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 6-251 1.86e-23

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 96.52  E-value: 1.86e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765    6 TLKGQCIAEFLGTGLLIFFGVGCVAALKVAGASFGQWEISVIWGLGVAMAIYLTAGVSGAHLNPAVTIALWLFACFDKRK 85
Cdd:PLN00182  40 CLTQKLIAEMIGTYFIIFSGCGVVVVNVLYGGTITFPGICVTWGLIVMVMIYSTGHISGAHFNPAVTVTFAIFRRFPWYQ 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765   86 VIPFIVSQVAGAFCAAalvygLYYNLFFDfeqthhivrgsvesVDLAGTFSTYPNPHINfvQAFAVEMVITAILMGLILA 165
Cdd:PLN00182 120 VPLYIGAQLTGSLLAS-----LTLRLMFN--------------VTPEAFFGTTPTDSSG--QALVAEIIISFLLMFVISG 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765  166 LTDDGNGVprGPLAPLLIGLLIAVIGASMGPLTGFAMNPARDFGPkvfawlagwgnvAFTGGRdIPYFLVPLFGPIVGAI 245
Cdd:PLN00182 179 VATDSRAV--GELAGIAVGMTIILNVFVAGPISGASMNPARSLGP------------AIVMGR-YKGIWVYIVGPFVGII 243


                 ....*.
gi 16131765  246 VGAFAY 251
Cdd:PLN00182 244 AGGFVY 249
PRK05420 PRK05420
aquaporin Z; Provisional
 10-257 4.55e-23

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 94.26  E-value: 4.55e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765   10 QCIAEFLGTGLLIFFGVG-CVAALKVAGASFGQWEISVIWGLGVAMAIYLTAGVSGAHLNPAVTIALWLFACFDKRKVIP 88
Cdd:PRK05420   4 KLAAEFFGTFWLVFGGCGsAVLAAAFPELGIGFLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPAKELVP 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765   89 FIVSQVAGAFCAAALVYglyynlffdfeqthhIVRGSVESVDLAGT------FSTYPNPHINFVQAFAVEMVITAILMGL 162
Cdd:PRK05420  84 YIIAQVVGGIAAAAVLY---------------LIASGKAGFDLAGSgfasngYGEHSPGGYSLLAALVCEVVLTAFFLLV 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765  163 ILALTDdgNGVPRGpLAPLLIGLLIAVIGASMGPLTGFAMNPARDFGPKVFAwlagwgnvaftGGRDIPYFLVPLFGPIV 242
Cdd:PRK05420 149 ILGATD--KRAPAG-FAPIAIGLALTLIHLISIPVTNTSVNPARSTGVALFV-----------GGWALEQLWLFWVAPIV 214

                        250
                 ....*....|....*
gi 16131765  243 GAIVGAFAYRKLIGR 257
Cdd:PRK05420 215 GAIIGGLIYRLLLEK 229
PLN00026 PLN00026
aquaporin NIP; Provisional
 13-251 9.40e-21

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 89.54  E-value: 9.40e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765   13 AEFLGTGLLIFFGV-GCVAALKVAGAS--FGQweiSVIWGLGVAMAIYLTAGVSGAHLNPAVTIALWLFACFDKRKVIPF 89
Cdd:PLN00026  76 AEFVGTFILIFAATaGPIVNQKYDGAEtlIGN---AACAGLAVMIVILSTGHISGAHLNPSLTIAFAALRHFPWKHVPAY 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765   90 IVSQVAGAFCAAALVYGLYynlffdfeqtHHIVRGSVESvdlagtfstypnPHINFVQAFAVEMVITAILMGLILALTDD 169
Cdd:PLN00026 153 IAAQVSASICASFALKGVF----------HPFMSGGVTV------------PSVSTGQAFALEFIITFNLLFVVTAVATD 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765  170 GNGVprGPLAPLLIGLLIAVIGASMGPLTGFAMNPARDFGPKVFAwlagwGNVaftggRDIPYFLVplfGPIVGAIVGAF 249
Cdd:PLN00026 211 TRAV--GELAGIAVGATVMLNILVAGPSTGGSMNPVRTLGPAVAA-----GNY-----RAIWIYLV---APTLGALAGAG 275


                 ..
gi 16131765  250 AY 251
Cdd:PLN00026 276 TY 277
PLN00166 PLN00166
aquaporin TIP2; Provisional
 12-212 9.52e-11

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 60.72  E-value: 9.52e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765   12 IAEFLGTGLLIFFGVGCVAAL-----KVAGASFGQWEISVIWGLGVAMAIYLTAGVSGAHLNPAVTIALWLFACFDKRKV 86
Cdd:PLN00166  22 LSEFIATLLFVFAGVGSAIAFakltsDAALDPAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIGGNITIITG 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765   87 IPFIVSQVAGAFCAAALVyglyynlffdfeqthhIVRGSVESVDLAGTFSTypnphINFVQAFAVEMVITAILMGLILAL 166
Cdd:PLN00166 102 FFYWIAQCLGSIVACLLL----------------VFVTNGESVPTHGVAAG-----LGAIEGVVMEIVVTFALVYTVYAT 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 16131765  167 TDDGNGVPRGPLAPLLIGLLIAVIGASMGPLTGFAMNPARDFGPKV 212
Cdd:PLN00166 161 AADPKKGSLGTIAPIAIGFIVGANILAAGPFSGGSMNPARSFGPAV 206
PLN00027 PLN00027
aquaporin TIP; Provisional
 2-251 7.52e-07

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 49.01  E-value: 7.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765    2 SQTSTLKGqCIAEFLGTGLLIFFGVGCVAA---LKVAGASF--GQWEISVIWGLGVAMAIYLTAGVSGAHLNPAVTIALW 76
Cdd:PLN00027  15 SHPDALKA-ALAEFISTLIFVFAGEGSGMAfnkLTDNGSTTpaGLVAAALAHAFALFVAVSVGANISGGHVNPAVTFGAF 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765   77 LFACFDKRKVIPFIVSQVAGAFCAAALvyglyynLFFdfeQTHHIVrgsvesvdlAGTFSTypNPHINFVQAFAVEMVIT 156
Cdd:PLN00027  94 IGGNITLLRGILYWIAQLLGSVVACLL-------LKF---STGGLE---------TSAFSL--SSGVGVWNAFVFEIVMT 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765  157 AILMGLILALTDDGNGVPRGPLAPLLIGLLIAVIGASMGPLTGFAMNPARDFGPKVFAWLagWGNvaftggrdipyFLVP 236
Cdd:PLN00027 153 FGLVYTVYATAVDPKKGDLGIIAPIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWT--WTN-----------HWVY 219

                        250
                 ....*....|....*
gi 16131765  237 LFGPIVGAIVGAFAY 251
Cdd:PLN00027 220 WAGPLIGGGIAGLVY 234
PLN00167 PLN00167
aquaporin TIP5; Provisional
 12-255 1.15e-06

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 48.75  E-value: 1.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765   12 IAEFLGTGLLIFFGVGCVAALK-----VAGASFGQWEISVIWGLGVAMAIYLTAGVSGAHLNPAVTIALWLFACFDKRKV 86
Cdd:PLN00167  26 LAEFISTFFFVFAAVGSAMSSRklmpdAASDPSSLLIVAIANAFALSSAVYIAANISGGHVNPAVTFGMAVGGHISVPTA 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765   87 IPFIVSQVAGAFCAAALVyglyynlffdfeqTHHIVRGSVESVDLAGTFSTYpnphinfvQAFAVEMVITAILMGLILAL 166
Cdd:PLN00167 106 MFYWISQMLASVMACLFL-------------KVTTVGQHVPTYKIAEEMTGF--------GASVLEGVLTFGLVYTVYAA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16131765  167 TDDGNGVPrGPLAPLLIGLLIAVIGASMGPLTGFAMNPARDFGPKVFAwlAGWGNVAftggrdipyflVPLFGPIVGAIV 246
Cdd:PLN00167 165 GDPRRGLL-GAIGPLAIGLVAGANVLAAGPFSGGSMNPACAFGSAVVA--GSFKNQA-----------VYWVGPLLGGAV 230


                 ....*....
gi 16131765  247 GAFAYRKLI 255
Cdd:PLN00167 231 AGLLYDNVV 239
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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