|
Name |
Accession |
Description |
Interval |
E-value |
| PRK12307 |
PRK12307 |
MFS transporter; |
1-405 |
0e+00 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 683.19 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 1 MATAWYKQVNPPQRKALFSAWLGYVFDGFDFMMIFYILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRK 80
Cdd:PRK12307 4 KFFPWYSEITRPQKNALFSAWLGYVFDGFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 81 PMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIP 160
Cdd:PRK12307 84 PLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGIGNIIAAYFMP 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 161 QFAEVYGWRNSFFIGLLPVLLVLWIRKSAPESQEWIEDKYKDKS------------TFLSVFRKPHLSISMIVFLVCFCL 228
Cdd:PRK12307 164 SFAEAYGWRAAFFVGLLPVLLVIYIRARAPESKEWEEAKLSGKGkhsqsawsvfslSMKGLFNRAQFPLTLCVFIVLFSI 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 229 FGANWPINGLLPSYLADNGVNTVVISTLMTIAGLGTLTGTIFFGFVGDKIGVKKAFVVGLITSFIFLCPLFFISVKNSSL 308
Cdd:PRK12307 244 FGANWPIFGLLPTYLAGEGFDTGVVSNLMTAAAFGTVLGNIVWGLCADRIGLKKTFSIGLLMSFLFIFPLFRIPQDNYLL 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 309 IGLCLFGLMFTNLGIAGLVPKFIYDYFPTKLRGLGTGLIYNLGATGGMAAPVLATYISGYYGLGVSLFIVTVAFSALLIL 388
Cdd:PRK12307 324 LGACLFGLMATNVGVGGLVPKFLYDYFPLEVRGLGTGLIYNLAATSGTFNSMAATWLGITMGLGAALTFIVAFWTATILL 403
|
410 420
....*....|....*....|...
gi 90111718 389 LVGFDIPGKI------YKLSVAK 405
Cdd:PRK12307 404 IIGLSIPDRLkarresFQSTKEF 426
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
4-401 |
5.49e-113 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 339.37 E-value: 5.49e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 4 AWYKQVNPPQRKALFSAWLGYVFDGFDFMMIFYILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMM 83
Cdd:PRK03893 9 PWYRHLNRAQWKAFSAAWLGYLLDGFDFVLITLVLTEVQGEFGLTTVQAASLISAAFISRWFGGLLLGAMGDRYGRRLAM 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 84 MWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFA 163
Cdd:PRK03893 89 VISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVV 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 164 EVYGWRNSFFIGLLPVLLVLWIRKSAPESQEWIE---DKYKDKSTFLSVFRKPHLSISMI-------------------- 220
Cdd:PRK03893 169 PVWGWRALFFIGILPIIFALWLRKNLPEAEDWKEkhaGKAPVRTMVDILYRGEHRIINILltlaaaaalwfcfagnlqna 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 221 -------------------------------VFLVCFCLFGANWPINGLLPSYL-ADNGVNTVVISTLMTIAGLGTLTGT 268
Cdd:PRK03893 249 aivavlgllcaaifisfmvqssgkrwptgvmLMVVVLFAFLYSWPIQALLPTYLkTDLGYDPHTVANVLFFSGFGAAVGC 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 269 IFFGFVGDKIGVKKAFVVGLITSFIFLCPLFFISVKNSSLIGLCLFGLMFTNLGIAGLVPKFIYDYFPTKLRGLGTGLIY 348
Cdd:PRK03893 329 CVGGFLGDWLGTRKAYVCSLLISQLLIIPVFAIGGANVWVLGLLLFFQQMLGQGISGLLPKLIGGYFDTEQRAAGLGFTY 408
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 90111718 349 NLGATGGMAAPVLATYISGYYGLGVSLFIVTVAFSALLILLVGFDIPGKIYKL 401
Cdd:PRK03893 409 NVGALGGALAPILGALIAQRLDLGTALASLSFSLTFVVILLIGLDMPSRVQRW 461
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
17-392 |
2.82e-68 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 219.78 E-value: 2.82e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 17 LFSAWLGYVFDGFDFMMIFYILHIIKA--DLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGT 94
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAefSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 95 GLSGIATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQI----IPQFAEVYGWRN 170
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVasllIPLLSGDWGWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 171 SFFIGLLPVLLVLWIRKSapesqewiedkykdkstflsvfrkphlsiSMIVFLVCFCLFGANWPINGLLPSYL-ADNGVN 249
Cdd:cd17316 161 LFLIGALPALLALLLRRR-----------------------------TLLLILLWFFISFGYYGLTTFLPTYLqTVLGLS 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 250 TVVISTLMTIAGLGTLTGTIFFGFVGDKIGVKKAFVVGLITSFIFLCPLFFISVKNSSLIGLCLFGLMFTNLGIAGLVPK 329
Cdd:cd17316 212 PATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYA 291
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 90111718 330 FIYDYFPTKLRGLGTGLIYNLGATGGMAAPVLATYISGYYGlGVSLFIVTVAFSALLILLVGF 392
Cdd:cd17316 292 YLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTG-GTGVPALILALLAIVALIVAL 353
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
17-389 |
2.89e-62 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 205.23 E-value: 2.89e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 17 LFSAWLGYVFDGFDFMMIFYILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGL 96
Cdd:cd17371 1 FWAAFLGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 97 SGIATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAA----QIIPQFAEVYGWRNSF 172
Cdd:cd17371 81 CGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATllaaLLFPLLPPEIAWRVLF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 173 FIGLLPVLLVLWIRKSAPESQEWIEDK-----YKDKSTFLSVFRKPHLSISMIVFLVCFCLFGANWPINGLLPSYL-ADN 246
Cdd:cd17371 161 LLGALPALLVLFIRRFVKEPPQWQAARaarrhFADRPSLRELFSPPLLRTTLLASLLATGALGGYYGITTWLPSYLtGER 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 247 GVNTVVISTLMTIAGLGTLTGTIFFGFVGDKIGVKKAFVVGLITSFIFLCPLFFISVKNSSLIGLCLFGLMFTNlGIAGL 326
Cdd:cd17371 241 GLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFLPLSPTLILILGFPLGFFAS-GPFSG 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 90111718 327 VPKFIYDYFPTKLRGLGTGLIYNLGATGGMAAPVLATYISGYYGLGVSL-FIVTVAFSALLILL 389
Cdd:cd17371 320 MGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIaVFAAVYYIAGLVLA 383
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
7-390 |
2.56e-45 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 160.04 E-value: 2.56e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 7 KQVNPPQRKALFSAWLGYVFDGFDFMMIFYILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWA 86
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 87 IFIYSVGTGLSGIATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVY 166
Cdd:COG2271 82 LLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 167 GWRNSFFIGLLPVLLVLWIRksapesqewiedkykdkstflsvfrkphlsiSMIVFLVCFCLFGANWPINGLLPSYLADN 246
Cdd:COG2271 162 GWRAAFLILGLPGLLLALLR-------------------------------FWLLALAYFLVYFALYGFLTWLPTYLVEV 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 247 -GVNTVVISTLMTIAGLGTLTGTIFFGFVGDKIGVKKAFVVGLITSFIFLCPLFFISVKNSSLIGLCLFGLMFTNLGIAG 325
Cdd:COG2271 211 rGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFG 290
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 90111718 326 LVPKFIYDYFPTKLRGLGTGLIYNLGATGGMAAPVLATYISGYYGLGVSLFIVTVAFSALLILLV 390
Cdd:COG2271 291 LLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLAL 355
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
9-365 |
3.52e-44 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 157.90 E-value: 3.52e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 9 VNPPQRKALFSAWLGYVFDGFDFMMIFYILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIF 88
Cdd:TIGR00895 11 LSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSIL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 89 IYSVGTGLSGIATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGW 168
Cdd:TIGR00895 91 LFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGW 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 169 RNSFFIG-LLPVLLVLWIRKSAPESQEWIEDKYKD-------------------------------KSTFLSVFRKPHLS 216
Cdd:TIGR00895 171 RSLFYVGgIAPLLLLLLLMRFLPESIDFLVSKRPEtvrrivnaiapqmqaeaqsalpeqkstqgtkRSVFKALFQGKTAR 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 217 ISMIVFLVCFCLFGANWPINGLLPSYLADNGVNTVVISTLMTIAGLGTLTGTIFFGFVGDKIGVKKAFVVGLITS-FIFL 295
Cdd:TIGR00895 251 ITVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAvFAVL 330
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 296 CPLFFISVKNSSLIGLCLFglMFTNLGIAGLvPKFIYDYFPTKLRGLGTGLIYNLGATGGMAAPVLATYI 365
Cdd:TIGR00895 331 VGSTLFSPTLLLLLGAIAG--FFVNGGQSGL-YALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAGYL 397
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
13-390 |
5.92e-44 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 157.35 E-value: 5.92e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 13 QRKALFSAWLGYVFDGFDFMMIFYILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSV 92
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 93 GTGLSGIATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSF 172
Cdd:COG2223 83 GLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 173 FIGLLPVLL--VLWIRKSAPESQEWIEDKYKDKSTFLSVFRKPHLsisMIVFLVCFCLFGANWPINGLLPSYLADN-GVN 249
Cdd:COG2223 163 LILGILLLVvaVLAWLFLRDPPAGAAAAAKASLRDQLEALRDPRF---WLLSLLYFGTFGSFIGFSSWLPPYLVDQfGLS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 250 TVVISTLMTIAGLGTLTGTIFFGFVGDKIGVKKAFVVGLITSFIFLCPLFFISvkNSSLIGLCLFGLMFTNLGIA-GLVP 328
Cdd:COG2223 240 AATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALAL--GSLWLFLVLFLLLGLALGGGnGAVF 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 90111718 329 KFIYDYFPTKLRGLGTGLIYNLGATGGMAAPVLATYI---SGYYGLGVSLFIVTVAFSALLILLV 390
Cdd:COG2223 318 ALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALldaTGSYTAAFLVFAVLALVALVLTLLL 382
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
11-358 |
1.07e-42 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 152.82 E-value: 1.07e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 11 PPQRKALFSAWLGYVFDGFDFMMIFYILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIY 90
Cdd:COG2814 6 RRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 91 SVGTGLSGIATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRN 170
Cdd:COG2814 86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 171 SFFIGLLPVLLVL-WIRKSAPESQEwiEDKYKDKSTFLSVFRKPHLsisMIVFLVCFCLFGANWPINGLLPSYLADN-GV 248
Cdd:COG2814 166 VFLVNAVLALLALlLLLRLLPESRP--AARARLRGSLRELLRRPRL---LLLLLLAFLLGFGFFALFTYLPLYLQEVlGL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 249 NTVVISTLMTIAGLGTLTGTIFFGFVGDKIGVKKAFVVGLITSFIFLCPLFFISVKNSSLIGLCLFGLMFTnlGIAGLVP 328
Cdd:COG2814 241 SASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFG--LLFPLLQ 318
|
330 340 350
....*....|....*....|....*....|
gi 90111718 329 KFIYDYFPTKLRGLGTGLIYNLGATGGMAA 358
Cdd:COG2814 319 ALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
17-391 |
7.33e-37 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 137.33 E-value: 7.33e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 17 LFSAWLGYVFDGFDFMMIFYILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGL 96
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 97 SGIATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSFFIGL 176
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 177 LPVLLVLwirksapesqewiedkykdkstflsvfrkPHLSISMIVFLVCFCLFGANWPINGLLPSYLADNGVNTVVISTL 256
Cdd:cd17365 161 VPPLILL-----------------------------PLLRGTLLLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTI 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 257 MTIAGLGTLTGTIFFGFVGDKIGVKKAFVVGLITSFIFLCpLFFISVKNSSLIGLCLFGLMFTNLGIAGLVPKFIYDYFP 336
Cdd:cd17365 212 TLLLNIGGVIGSLLLGWLADRFGPKRVLALFFALGAVSLA-LLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYP 290
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 90111718 337 TKLRGLGTGLIYNLGATGGMAAPVLATYISGyYGLGVS----LFIVTVAFSALLILLVG 391
Cdd:cd17365 291 TEVRATGVGWALGVGRLGAILGPLLGGLLLA-AGLGPEsvflALAIPAALGALAVLLLR 348
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
14-390 |
4.49e-35 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 133.42 E-value: 4.49e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 14 RKALFSAWLGYVFDGFDFM-------MIFYILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWA 86
Cdd:cd17369 1 RRVALASLVGTAIEWYDFFiygtaaaLVFNKLFFPAVDPAAGTLAAFATFGVGFLARPLGGVVFGHFGDRIGRKKTLVLT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 87 IFIYSVGTGLSGI----------ATNLymLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAA 156
Cdd:cd17369 81 LLLMGIATFLIGLlptyaqigilAPIL--LVLLRLLQGLALGGEWGGAVLMAVEHAPPKRRGFYGSFPQLGAPVGLLLAT 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 157 QII---------PQFAEvYGWRNSFFIGLLPVLLVLWIRKSAPESQEWIEDKYKDKST---FLSVFRKPHLSIsMIVFLV 224
Cdd:cd17369 159 GVFlllsallsdEAFLS-WGWRIPFLLSAVLVAVGLYIRLRLEETPVFRRAKEAGQVVrapLVEVLRRHWRAL-LLAIGL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 225 CFCLFGANWPINGLLPSYLADN-GVNTVVISTLMTIAGLGTLTGTIFFGFVGDKIGVKKAFVVGLITSFIFLCPLFFISV 303
Cdd:cd17369 237 RLAENVLFYLFTTFALSYATQTlGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLD 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 304 KNSSLIGLC--LFGLMFTNLGIAGLVPKFIYDYFPTKLRGLGTGLIYNLGAT-GGMAAPVLATYISGYYG--LGVSLFIV 378
Cdd:cd17369 317 TGSTWLIVLaaVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGYQLGAIlGGGFAPLIATALVAATGswWPVALYLA 396
|
410
....*....|..
gi 90111718 379 TVAFSALLILLV 390
Cdd:cd17369 397 ALAVISLVAALF 408
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
30-390 |
8.84e-30 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 118.42 E-value: 8.84e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 30 DFMMIFYILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVC 109
Cdd:cd17324 14 TEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 110 RFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSF-FIGLLPVLLVLWIRKS 188
Cdd:cd17324 94 RALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFlAIAVLALLAALLLWRL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 189 APESQEWIEDKYKDKSTFLSVFRKPHL-SISMIVFLVCFCLFGAnWPInglLPSYLADN-GVNTVVISTLMTIAGLGTLT 266
Cdd:cd17324 174 LPSLPPKKPGSLGLLSSLLLLLRNPRLrLAYLITFLLFGGFFAL-YTY---LAPFLTDVpGFSSSAIIGLLLLFGVAGVV 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 267 GTIFFGFVGDKIGVKKAFVVGLITSFIFLCPLFFISVKNSSLIGLCLFGLMFTnlGIAGLVPKFIYDYFPtKLRGLGTGL 346
Cdd:cd17324 250 GSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFF--AAHSALQTRVLRLAP-EARGLASSL 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 90111718 347 ---IYNLGATGGmaaPVLATYISGYYGLGvSLFIVTVAFSALLILLV 390
Cdd:cd17324 327 ylaAYNLGGALG---AALGGLVLDHGGWA-GVGWVGAALLLLALLLA 369
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
21-359 |
6.71e-29 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 115.21 E-value: 6.71e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 21 WLGYVFDGFDFMMIFYILH-IIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGI 99
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 100 ATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSFFI--GLL 177
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIlaILS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 178 PVLLVLWIRKSAPESQEWIEDKYKDKSTFLSVFRKPHLSISMIVFLVCFCLFGANWPINGLLPSYLADNGVNTVVISTLM 257
Cdd:pfam07690 162 LLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 258 TIAGLGTLTGTIFFGFVGDKIGVKKAFVVGLITSFIFLCPLFFISVKNSSLIGLCLFGLMFTNLGIA-GLVPKFIYDYFP 336
Cdd:pfam07690 242 GLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVfPALNALVSDLAP 321
|
330 340
....*....|....*....|...
gi 90111718 337 TKLRGLGTGLIYNLGATGGMAAP 359
Cdd:pfam07690 322 KEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
21-392 |
7.57e-29 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 115.75 E-value: 7.57e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 21 WLGYVFDGFDFMMIFYILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIA 100
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 101 TNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSFFI----GL 176
Cdd:cd17325 82 TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVcaalAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 177 LPVLLVLWIRKSAPESQEWIEDKYKDKSTFLSVFRKPH-LSISMIVFLVCFCLFGANWPingLLPSYLADN-GVNTVVIS 254
Cdd:cd17325 162 LALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRrLLALFLAIFVLAFAFGALEP---FLPLYAAELgGLSPAQIG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 255 TLMTIAGLGTLTGTIFFGFVGDKIGVKKAFVVGLITSFIFLCPLFFISVKNSSLIGLCLFGLMFTNLGIAGLVpkFIYDY 334
Cdd:cd17325 239 LLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLA--LLADI 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 90111718 335 FPTKLRGLGTGLIYNLGATGGMAAPVLATYISGYYGLGvSLFIVTVAFSALLILLVGF 392
Cdd:cd17325 317 VPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFA-TPFLAAAALLLLAAVLFLL 373
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
11-295 |
1.62e-27 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 110.67 E-value: 1.62e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 11 PPQRKALFSAWLGYVFDGFDFMMIFYILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIY 90
Cdd:COG0477 10 RRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLF 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 91 SVGTGLSGIATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRN 170
Cdd:COG0477 90 GLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRW 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 171 SFFIGLLPVLLVLWIRKSAPESQEWIEDKYKDKSTFLSVFRKPHLSISMIVFLVCFCLFGANWPINGLLPSYLADNGVNT 250
Cdd:COG0477 170 IFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLA 249
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 90111718 251 VVISTLMTIAGLGTLTGTIFFGFVGDKIGVKKAFVVGLITSFIFL 295
Cdd:COG0477 250 LLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALL 294
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
10-388 |
6.38e-26 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 108.02 E-value: 6.38e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 10 NPPQRKALFSAWLGYVFDGFDFMMIFYILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFI 89
Cdd:COG0738 3 KKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 90 YSVGTGLSGIATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNlQSKASAFLVSGFSVGNIIAAQIIPQFAEV---Y 166
Cdd:COG0738 83 MALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPET-AASRLNLLHAFFSLGALLGPLLGGLLILLglsL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 167 GWRNSFFI--GLLPVLLVLWIRKSAPESQEWIEDKYKDKSTFLSVFRKPHLsisMIVFLVCFCLFGANWPINGLLPSYLA 244
Cdd:COG0738 162 SWHLPYLIlaVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRL---LLGGLAIFLYVGAEGAIGDWLPLYLK 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 245 DN-GVNTVVISTLMTIAGLGTLTGTIFFGFVGDKIGVKKAFVVGLITSFIFLCPLFFISVKNSSLIGLCLFGLMF----- 318
Cdd:COG0738 239 DVlGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLslmfp 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 319 TNLGIAGLVPKfiydyfptKLRGLGTGLIYNLGATGGMAAPVLATYISGYYGLGVSLFIVTVAFSALLIL 388
Cdd:COG0738 319 TIFSLALDGLG--------KRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLL 380
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
22-390 |
3.23e-25 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 105.35 E-value: 3.23e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 22 LGYVFDGFDFMMIFYILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIAT 101
Cdd:cd17319 10 LAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 102 NLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSFFI-GLLPVL 180
Cdd:cd17319 90 SLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIeGLLGLL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 181 LVLWIRKSAPESqewiedkykdkstflsvfrkphlsisMIVFLVCFCLFGANWPINGLLPSYLADN-GVNTVVISTLMTI 259
Cdd:cd17319 170 LAVLWWFYLRQV--------------------------WGLALGYFGINYALYGLLTWLPTYLKQArGFSLKQVGLLAAI 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 260 AGLGTLTGTIFFGFVGDKIGVKKAFVVGLITSFIFLCPLFFISVKNSS-----LIGLCLFGLMFTNLGIAGLVPkfiyDY 334
Cdd:cd17319 224 PFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPvvaviLLSLAGFGIGAASPVFWSLPA----DL 299
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 90111718 335 FPTKLRGLGTGLIYNLGATGGMAAPVLATYI---SGYYGLGVSLFIVTVAFSALLILLV 390
Cdd:cd17319 300 LPGEAAATAGGLINSGGNLGGFVAPLLIGYLvdaTGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
58-390 |
8.41e-24 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 101.99 E-value: 8.41e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 58 VAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNL--------YMLAVCRFIVGLGMSGEYACASTYAV 129
Cdd:cd17367 48 VGFLMRPIGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYatigiwapIILLLARLLQGLSVGGEYGTSATYLS 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 130 ESWPKNLQSKASAFLVSGFSVGNIIAAQII---------PQFAEvYGWRNSFFIGLLPVLLVLWIRKSAPESQEWIE--D 198
Cdd:cd17367 128 EVAPPGRRGFYSSFQYVTLIGGQLLALGVLlvlqhtlgeDQMAA-WGWRIPFLLGGVLAVVVLWLRRGLEETESFEAiaE 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 199 KYKDKSTFLSVFRKpHLSISMIVFLVCFCLFGANWPINGLLPSYLADN-GVNTVVISTLMTIAGLGTLTGTIFFGFVGDK 277
Cdd:cd17367 207 SNEASAGTLRELRR-HPRELLLVVGLTAGGTLAFYTWTTYLQKFLVNTaGFSKGDATWITTAALLVFMLLQPLGGRLSDR 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 278 IGVKKAFVVGLITSFIFLCPLFFISVKNSS---LIGLCLFGLMFT--NLGIAGLVPKfiyDYFPTKLRGLGTGLIYNLG- 351
Cdd:cd17367 286 IGRRPLLLFFGIGGTLATVPLLSALDHTDSpytAFALVLVGLVFLsgYTSINAVVKA---ELFPTHVRALGVGLPYALAv 362
|
330 340 350
....*....|....*....|....*....|....*....
gi 90111718 352 ATGGMAAPVLATYISGYygLGVSLFIVTVAFSALLILLV 390
Cdd:cd17367 363 AIFGGTAPYVALWLKSI--GHEWVFFWYVAGLIAISLVV 399
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
20-389 |
1.10e-22 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 98.65 E-value: 1.10e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 20 AWLGYVFDGFDFMMIFYILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGI 99
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 100 ATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAE--VYGWRNSFFIGLL 177
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 178 PVLLVL----WIRKSAPESQEWIEDKYKDKSTFLSVFRKPHLSISMIVFLVCFCLFGANWPINGLLPSYLADNGVNTV-V 252
Cdd:cd06174 161 LALLAAilllLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVaV 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 253 ISTLMTIAGLGTLTGTIFFGFVGDK-IGVKKAFVVGLITSFIFLCPLFFISVKNSSLIGLCLFGLMFTNLGIAGLVpkFI 331
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFA--LI 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 90111718 332 YDYFPTKLRGLGTGLIYNLGATGGMAAPVLATYISGYYGLGVSLFIVTVAFSALLILL 389
Cdd:cd06174 319 AELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAIL 376
|
|
| MFS_CitA |
cd17368 |
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ... |
17-365 |
1.08e-20 |
|
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340926 [Multi-domain] Cd Length: 407 Bit Score: 93.21 E-value: 1.08e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 17 LFSAWLGYVFDGFDFMMI-FYILHIIKADLGITDIQATLIGTVA-----FIARPIGGGFFGAMADKYGRKPMMMWAIFIY 90
Cdd:cd17368 1 ILAATSGNALEFFDFGVYgFFAVYIGRLFFPSGSEFASLLLTFAtfgvgFFMRPIGAIVLGAYADRIGRKPAMTLTLAIM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 91 SVGTGLSGI----------ATNLYMLAvcRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQI-- 158
Cdd:cd17368 81 ALGTLLIALaptyatigiaAPLLVLLA--RLLQGFAAGGEVGGVTAYLVEAAPPGRRGFYTSWQSASQQVAIVAGALVgy 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 159 -----IPQFA-EVYGWRNSFFIGLLPVLLVLWIRKSAPESQEWIEDKYK-DKSTFLSVFRKPHLSISMIVFLVCFCLFgA 231
Cdd:cd17368 159 llsltLTAEAlAEWGWRIPFFIGLLIIPLGLWLRRSLEETEAFLERKARpTRRELFALLANNRRIILLGMLLVAGSTV-T 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 232 NWPINGLLPSYLADN-GVNTVVISTLMTIAGLGTLTGTIFFGFVGDKIGVKKAFVVGLITSFIFLCPLFFISVKNSSLIG 310
Cdd:cd17368 238 FYFTTVYTPTYAKTVlGLSARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAALVTLYPVFAWLTAAPSFGR 317
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 90111718 311 LCLFGLMFTNLGIAGLVPKF--IYDYFPTKLRGLGTGLIYNLG-ATGGMAAPVLATYI 365
Cdd:cd17368 318 LLLVLLVLSFFFGMYGGAMVvaLVELFPVRVRSTGFSLVYALAvAIFGGFAQFIVTWL 375
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
37-389 |
1.11e-20 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 92.62 E-value: 1.11e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 37 ILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLG 116
Cdd:cd17478 18 LLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 117 MSGEYACASTYAVESWPKNLQSKASAFLVSG---FSVGNIIAAQIIPQFAEVYGWRNSFFIGLLPVLLVLWIRKSAPESQ 193
Cdd:cd17478 98 SAAFHPEGARLASQAAGGRRGLAMSIFSVGGnlgFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 194 EWIEDKYKDKSTFLSVFRkPHLSISMIVFLVCFCLFGanwpINGLLPSYLADNGVNTVVISTLMTIAGLGTLTGTIFFGF 273
Cdd:cd17478 178 KKAAAKSSARSTLKGVWR-ALLLLLIIVFLRSWVLSS----LTTFLPFYLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGP 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 274 VGDKIGVKKAFVVGLITSFIFLCPLFF----ISVKNSSLIGLCLFGLMFTNLGIAGlvpkfiyDYFPTKlRGLGTGLIYN 349
Cdd:cd17478 253 LSDRFGRRRVIIASLLLAAPFLLLFLLtpgiWSYILLVLAGFLLFASFPVTVVLAQ-------ELLPGN-VGLASGLMMG 324
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 90111718 350 LG-ATGGMAAPVLAtYISGYYGLGVSLFIVTV-AFSALLILL 389
Cdd:cd17478 325 LSfGLGGIGAPVLG-ALADAFGLESVLLILALlPLLGALLAF 365
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
37-390 |
1.90e-20 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 92.24 E-value: 1.90e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 37 ILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLG 116
Cdd:COG2807 40 LLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAG 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 117 MSGEYACASTYAVESWPKNLqSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSF-------FIGLLPVLLVLWIRKSA 189
Cdd:COG2807 120 IAVGNVLLPGLIKRWFPDRV-GLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALavwallaLLALLLWLPLLRRRPAA 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 190 PESQEWiedkykdKSTFLSVFRKPHLSISMIVFLVCFCLFGAnwpINGLLPSYLADNGVNTVVISTLMTIAGLGTLTGTI 269
Cdd:COG2807 199 AAAAPA-------AASLRSLWRSPLAWLLTLFFGLQSLLYYA---VVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSL 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 270 FFGFVGDKIGVKKAFVVGLITSFIFLCPLFFISVKNSSLIGLCLFGLMFTnlGIAGLVPKFIYDYFPTKLR-GLGTGLIY 348
Cdd:COG2807 269 LVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQG--GLFPLALTLIGLRARTPAEaAALSGMAQ 346
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 90111718 349 NLGATGGMAAPVLATYISGYYGLGVSLFIVTVAFSALLILLV 390
Cdd:COG2807 347 SVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAG 388
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
49-395 |
2.36e-20 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 92.33 E-value: 2.36e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 49 DIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIAT---NLYMLAVCRFIVGLGMSGEYACAS 125
Cdd:pfam00083 45 SVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGVGGASVLAP 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 126 TYAVESWPKNLQSKASAFLVSGFSVGNIIAA---QIIPQFAEVYGWRNSFFIGLLPVLLVL------------------- 183
Cdd:pfam00083 125 MYISEIAPKKLRGALGSLYQLAITFGILLAYifgLGLNKTSNSDGWRIPLGLQLVPALLLIigllflpesprwlvekgrl 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 184 --------WIRKSAPESQEWIE--DKYKDKSTFLSVFRKPHLS-------ISMIVFLVCFCLFGANWPINGLLPSYLADN 246
Cdd:pfam00083 205 eearevlaKLRGVPDVDRELDEikDSLEAGQEAEKASWKELFStktrrqrLLIGVMLQIFQQLTGINAIFYYSTTIFENL 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 247 GVNTVVISTLmtIAGLGTLTGTIFFGFVGDKIGVKKAFVVGLIT---SFIFLCPLFFISVKNSSLIG-----LCLFGLMF 318
Cdd:pfam00083 285 GLSDSFLVTI--IVGVVNFVFTFIAIFLVDRFGRRPLLLLGAAGmaiCFVILGIVALLGVSKSDWAGivaivFIALFIAF 362
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 90111718 319 TNLGIAGLVPKFIYDYFPTKLRGLGTGLIYNLGATGGMAAPVLATYISGYYGLGVSlFIVTVAFSALLILLVGFDIP 395
Cdd:pfam00083 363 FAMGWGPVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGYT-FFIFAGLLVLFIIFVFFFVP 438
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
43-388 |
1.95e-19 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 89.25 E-value: 1.95e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 43 ADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLGMSGE-Y 121
Cdd:cd17355 31 AEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTlA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 122 ACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSF-----FIGLLPVLLVLWIRKSAPESQEWI 196
Cdd:cd17355 111 AVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALlvlalLALLVLVPVLLLLRRRPADLALRA 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 197 EDKYKDKS---TFLSVFRKPHLSISMIVFLVcfCLFGANWPInGLLPSYLADNGVNTVVISTLMTIAGLGTLTGTIFFGF 273
Cdd:cd17355 191 YDDASPASpgsTLKEALRSASFWLLALAFFL--CGFAVVGLI-VHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGW 267
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 274 VGDKIGVKKAFVVGLITSFIFLCPLFFISVKNSSLIGLCLFgLMFTNLGIAGLVPKFIYDYFPTKLRGLGTGLIYNLGAT 353
Cdd:cd17355 268 LGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAAL-FGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQL 346
|
330 340 350
....*....|....*....|....*....|....*...
gi 90111718 354 GGMAAPVLATYI---SGYYGLGVSLFIVTVAFSALLIL 388
Cdd:cd17355 347 GSALGPWLGGLLydrTGSYTAAWALAVALGLIAALLVL 384
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
20-388 |
5.66e-19 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 87.70 E-value: 5.66e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 20 AWLGYVFDGFDFMMIFYILHIIKADLGITDIQ-----ATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGT 94
Cdd:cd17391 1 CWLGNFFTGIGFSLIAPFLPLYIEQLGVTSGGlvelwSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 95 GLSGIATNLYMLAVCRFIVGLgMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSFFI 174
Cdd:cd17391 81 GLMAFVTNVWQLLILRLLQGV-FSGYVPNATALIASQTPKEKSGWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 175 G----LLPVLLVLWIRKSAPESQEwIEDKYKDKSTFLSVFRKPhLSISMIV--FLVCFCLFGANwPINGLLPSYLADNGV 248
Cdd:cd17391 160 TggllFLAFLLTLFFVKEDFKPVE-KKKMVSTKEVWNSVPNPS-LLISLFVttFIIQLANQSIE-PILTLYIRQLMGDAS 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 249 NTVVISTL-MTIAGLGTLTGTIFFGFVGDKIGVKKAFVVGLITSFIFLCPLFFisVKNSSLIGLCLFGLMFTNLGIAGLV 327
Cdd:cd17391 237 NLAFISGLvFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAF--VQTPWQLGILRFLLGLATGGLLPAI 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 90111718 328 PKFIYDYFPTklRGLGTGLIYNLGAT--GGMAAPVLATYISGYYGLGVSLFI--VTVAFSALLIL 388
Cdd:cd17391 315 NSLLAKITPK--EVAGRIFGYNQSFQylGNVAGPLLGSAIAAHFGYRAVFVVtaLLVLLNAIWSF 377
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
14-321 |
9.83e-19 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 87.48 E-value: 9.83e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 14 RKALFSAWLGYVFDGFDFMmifyiLHIIKADL--------GITDIQATLIG----TVAFIARPIGGGFFGAMADKYGRKP 81
Cdd:PRK09952 21 RRAALGSFAGAVVDWYDFL-----LYGITAALvfnreffpQVSPAMGTLAAfatfGVGFLFRPLGGVVFGHFGDRLGRKR 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 82 MMMWAIFIYSVGTGLSGIATNL--------YMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNI 153
Cdd:PRK09952 96 MLMLTVWMMGIATALIGLLPSFstigwwapVLLVTLRAIQGFAVGGEWGGAALLAVESAPKNKKAFYSSGVQVGYGVGLL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 154 IAAQIIP---------QFAEvYGWRNSFFIGLLPVLLVLWIRKSAPESQEWIEDKYKDKS------TFLSVFRKPHLSIS 218
Cdd:PRK09952 176 LSTGLVSlismmttdeQFLS-WGWRIPFLFSIVLVLIALWVRNGMEESAEFEQQQHEQAAakkripVIEALLRHPGAFLK 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 219 MIVFLVCFCL-------FGANWPINGL-LPSYLADNgvntvvISTLmtIAGLGTLTgTIFFGFVGDKIGVKKAFVVGLIT 290
Cdd:PRK09952 255 IIALRLCELLtmyivtaFALNYSTQNLgLPRELFLN------IGLL--VGGLSCLT-IPCFAWLADRFGRRRVYITGALI 325
|
330 340 350
....*....|....*....|....*....|.
gi 90111718 291 SFIFLCPlFFISVKNSSLIGLCLFGLMFTNL 321
Cdd:PRK09952 326 GTLSAFP-FFMALEAQSIFWIVFFSIMLANI 355
|
|
| PRK10642 |
PRK10642 |
proline/glycine betaine transporter ProP; |
14-369 |
7.40e-18 |
|
proline/glycine betaine transporter ProP;
Pssm-ID: 182611 [Multi-domain] Cd Length: 490 Bit Score: 85.15 E-value: 7.40e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 14 RKALFSAWLGYVFDGFDFMMIFYILHII------KADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAI 87
Cdd:PRK10642 15 RKAITAASLGNAMEWFDFGVYGFVAYALgkvffpGADPSVQMIAALATFSVPFLIRPLGGLFFGMLGDKYGRQKILAITI 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 88 FIYSVGTGLSGIATNL--------YMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFL----VSGFSVGNIIA 155
Cdd:PRK10642 95 VIMSISTFCIGLIPSYatigiwapILLLLCKMAQGFSVGGEYTGASIFVAEYSPDRKRGFMGSWLdfgsIAGFVLGAGVV 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 156 AQIIPQFAEV----YGWRNSFFIGLLPVLLVLWIRKSAPES---QEWIEDKYKDKSTFLSvfRKPHLSISMIV------F 222
Cdd:PRK10642 175 VLISTIVGEAnfldWGWRIPFFIALPLGIIGLYLRHALEETpafQQHVDKLEQGDREGLQ--DGPKVSFKEIAtkhwrsL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 223 LVCFCLFGAN----WPINGLLPSYLA-------DNGVntVVISTLMtiagLGTLTGTIFFGFVGDKIGVKKAFVVGLITS 291
Cdd:PRK10642 253 LTCIGLVIATnvtyYMLLTYMPSYLShnlhyseDHGV--LIIIAIM----IGMLFVQPVMGLLSDRFGRRPFVILGSVAL 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 292 FIFLCPLFFISvkNSSLIGLCLFGLMFTNLGI---AGLVPKFIYDYFPTKLRGLGTGLIYNL-----GATGGMAAPVLAT 363
Cdd:PRK10642 327 FVLAIPAFILI--NSNVIGLIFAGLLMLAVILncfTGVMASTLPAMFPTHIRYSALAAAFNIsvlvaGLTPTLAAWLVES 404
|
410
....*....|
gi 90111718 364 ----YISGYY 369
Cdd:PRK10642 405 tqnlMMPAYY 414
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
40-392 |
1.03e-17 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 83.78 E-value: 1.03e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 40 IIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLGMSG 119
Cdd:cd17473 25 IAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 120 EYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVyGWRNSFFIGLLPVLLVLWIRKSAPESQEwiEDK 199
Cdd:cd17473 105 IMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWRAPFLVYLLALPVLILVLLFLPEPAR--KSK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 200 YKDKSTFLSVFRKPHLSISMIVFLVcFCLFGANWPINGLLPSYLADNG-VNTVVISTLMTIAGLGTLTGTIFFGFVGDKI 278
Cdd:cd17473 182 SAASPGAATAAALPWKRVLPIYFLA-FLAMLLFYVIPIQLPFLLQERGgGSAALIGLALAIASLAGAIGALLFGRLKRRL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 279 GVKKAFVVGLItsfIFLCPLFFISVknSSLIGLCLFGLMFTNLGIAGLVP---KFIYDYFPTKLRGLGTGLIYNLGATGG 355
Cdd:cd17473 261 GKRRLLAIGFA---LMALGFLLLAL--ASGLWVVLLGAILAGLGFGLLLPtlnSWAMSLVPPELRGRAMGIVTSAFFLGQ 335
|
330 340 350
....*....|....*....|....*....|....*..
gi 90111718 356 MAAPVLATYISGYYGLGVSLFIVTVAFSALLILLVGF 392
Cdd:cd17473 336 FLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLL 372
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
32-365 |
2.40e-17 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 82.63 E-value: 2.40e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 32 MMIFYILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRF 111
Cdd:cd17504 13 TMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 112 IVGLGMsGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSFFIGLLPVLLVLWIrksAPe 191
Cdd:cd17504 93 LQGIGG-AVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAAL---VP- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 192 sqewIEDkykdkstfLSVFRKPH-LSISMIVFLVCFCLFGANwpinGLLPSYLADN-----GVNTVVISTLMTIAGLGTL 265
Cdd:cd17504 168 ----LID--------LRLLRRRNvLLANITALLAGFGMFMVF----QLLPQLLQLPtptgfGLGITEAGLLLLPGALVML 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 266 TGTIFFGFVGDKIGVKKAFVVGLITSFIFLCplfFISVKNSSLIgLCLFGLMFTNLGIAGL---VPKFIYDYFPTKLRGL 342
Cdd:cd17504 232 IAGPLAGRLIARVGPRRVLLIGLVISAVGLL---LLALLHSSLW-ALVVALLLIGIGLGLAfasLPNIVVESVPPDRTGI 307
|
330 340
....*....|....*....|...
gi 90111718 343 GTGLIYNLGATGGMAAPVLATYI 365
Cdd:cd17504 308 ATGMNTVLRTIGSAIGPAIAGAI 330
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
31-390 |
4.42e-17 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 81.87 E-value: 4.42e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 31 FMMIFYILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCR 110
Cdd:cd17489 12 FYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLR 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 111 FIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSFFIGL---LPVLLVLWIRK 187
Cdd:cd17489 92 LIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAvlaLLALLLVFLVK 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 188 SAPESQEwiEDKYKDKSTFLSVFRKPHLSISMIVFLVCFCLFGanwpINGLLPSYLADNGVntVVISTLMTIAGLGTLTG 267
Cdd:cd17489 172 DPPPVAA--EEAEAGTRAFRRLVEKKVLPPALILFLASIAYGA----ISTFLPLYAAERGI--SNAGLFFTVYAIALLLS 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 268 TIFFGFVGDKIGVKKAFVVGLITSFIFLCPLFFISVKNSSLIGLCLFGLMFTNLGIAGLVpkFIYDYFPTKLRGLGTGLI 347
Cdd:cd17489 244 RPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQA--LAVDLVPPHRRGAANGTF 321
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 90111718 348 YNLGATGGMAAPVLATYISGYYGLGVsLFIVTVAFSALLILLV 390
Cdd:cd17489 322 FIFFDLGIGLGGLLLGLVAELFGYRA-MFLLAAVVVLLALVLY 363
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
41-390 |
1.86e-16 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 80.35 E-value: 1.86e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 41 IKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCR-FIVGLGMSG 119
Cdd:cd17353 29 LSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYgVLGGIGAGI 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 120 EYACASTYAVEsWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSFFI-----GLLPVLLVLWIR-------K 187
Cdd:cd17353 109 GYITPVSTAVK-WFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLIlgiifLIIIVIGAFLIRdppkgwvP 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 188 SAPESQEWIEDKYKDKSTFLSVFRKPH-LSISMIVFLVCFCLFGanwpINGLLPSYLAD-NGVNTVVISTLMTIAGLGTL 265
Cdd:cd17353 188 PGVDPLANNAENSPRDYTPREMLRTPTfWLLWLMFFLNATAGLM----LIGQAKPIGQEfAGLDAGIAALAVSILSIFNG 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 266 TGTIFFGFVGDKIGVKKA-FVVGLITSFIFLCPLFFISVKNSSLIGLCLFGLMFTnlGIAGLVPKFIYDYFPTKLRGLGT 344
Cdd:cd17353 264 GGRPFWGWLSDKIGRKNTlSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYG--GGFALFPALTADFFGTKNAGTNY 341
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 90111718 345 GLIYNLGATGGMAAPVLATYISGYYGLGVSLFIVTV--AFSALLILLV 390
Cdd:cd17353 342 GLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAAlsLVALALALLL 389
|
|
| MFS_ProP |
cd17366 |
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This ... |
57-382 |
3.54e-16 |
|
Proline/betaine transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of Escherichia coli proline/betaine transporter, also called proline porter II (PPII), and similar proteins. ProP is a proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response. The ProP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340924 [Multi-domain] Cd Length: 377 Bit Score: 79.32 E-value: 3.54e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 57 TVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGI--------ATNLYMLAVCRFIVGLGMSGEYACASTYA 128
Cdd:cd17366 47 AVAFLVRPLGGLVFGPLGDKYGRQKVLAITIILMAASTFCIGLlptyatigVWAPILLLLARMVQGFSTGGEYGGAATFV 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 129 VESWPKNLQSKASAFL----VSGFSVGNII----AAQIIPQFAEVYGWRNSFFIGLLPVLLVLWIRKSapesqewiedky 200
Cdd:cd17366 127 AEYAPDRKRGFLGSWLefgtLAGFILGAGLvtllTLLLTEAQMLDWGWRIPFLIAAPLGLVGLYLRRP------------ 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 201 kdkstflsvfrkphlsismivFLVCFCLFGA----NWPINGLLPSYLADN-GVNTVVISTLMTIAGLGTLTGTIFFGFVG 275
Cdd:cd17366 195 ---------------------LLICIGLVLVfnvtNYMLLSYMPSYLEETlGYSETHGLLVIIIIMVTMLVLQPFLGRLS 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 276 DKIGVKKAFVVGLITSFIFLCPLFFISVKNS---SLIGLCLFGLMFTNLgiAGLVPKFIYDYFPTKLRGLGTGLIYNLG- 351
Cdd:cd17366 254 DRVGRKPVYAAGLAGLLVLAVPAFLLMNSGSiaaIFIGLLVLGLLLSCY--TATMASTLPALFPTHVRYSALAIAFNISv 331
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 90111718 352 ATGGMAAPVLATYISG---------YYGLGVSLF-IVTVAF 382
Cdd:cd17366 332 SLFGGTTPLVASWLVSatgnplmpaYYLMVAAVVgLVAVLF 372
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
41-390 |
1.93e-15 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 76.82 E-value: 1.93e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 41 IKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCR-FIVGLGMSG 119
Cdd:cd17352 29 LLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTYgVLGGLGLGL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 120 EYaCASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSFFI--GLLPVLLVLwirksapesqewie 197
Cdd:cd17352 109 IY-SPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLIlgGLCLNLCVC-------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 198 dkykdkSTFLSVFRKPHLSIsmIVFLVCFCLFGANWPInGLLPSYLADNGVNTVVISTLMTIAGLGTLTGTIFFGFVGDK 277
Cdd:cd17352 174 ------GLLLRLLKDPTFVL--LALGVSFAMLGFFVPF-VYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADK 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 278 IGVKKAFVVGLITSFIFLCPLFF-ISVKNSSLIGLC-LFGLMFTnlGIAGLVPKFIYDYFPTKLRGLGTGLIYNLGATGG 355
Cdd:cd17352 245 PRIGRLYLYIFTLLILGLSLLAFpLATTYVGLIVFSvLFGFCSG--SYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAA 322
|
330 340 350
....*....|....*....|....*....|....*...
gi 90111718 356 MAAPVLATYISGYYGLGVSLFI---VTVAFSALLILLV 390
Cdd:cd17352 323 LVGPPIAGLLRDYTGDYDAAFYfcgACLLLSGVLLFLL 360
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
33-389 |
5.09e-15 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 75.68 E-value: 5.09e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 33 MIFYILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFI 112
Cdd:cd17474 17 IVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 113 VGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGnIIAAQIIPQFAEVYGWRNSFF----IGLLPVLLVLWIRKS 188
Cdd:cd17474 97 QGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLG-IAVGPLLGGLLAAISWRYPFFllaaLIPVAFLAILFLLPE 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 189 APESQEWIeDKYKDKSTFLSVFRKPHLSISMIVFLVCFCLFGanwpINGLLPSYLADN-GVNTVVISTLMTIAGLGTLTG 267
Cdd:cd17474 176 PKEKAKSS-SATKLRDLKKALRGRGLLTFLVSAFLYFFLYFA----FLTYLPFLLELLyGISPIIIGLLFAGWSVLLALG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 268 TIFFG-FVGDKIGVKKAFVVGLITSFIFLCPLFFISVKNSSLIGLCLFGLMftnLGIA-GLVPKFIYDYFPTKLRGLGTG 345
Cdd:cd17474 251 SLFVGrLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLG---LGLNlPLLTTLVTELAPEEERGTASS 327
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 90111718 346 LiYNLGATGGMA-APVLATYISGYYGLGVSLFIVTVAFSALLILL 389
Cdd:cd17474 328 L-YNFVRFLGQAvGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLL 371
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
59-362 |
1.50e-14 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 74.61 E-value: 1.50e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 59 AFIARPIG---GGFFGAM-ADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPK 134
Cdd:PRK11551 55 AFSAGILGllpGALLGGRlADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGP 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 135 NLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSFFI-GLLPVLLVLWIRKSAPESQEWIEDKYKDK---STFLSVF 210
Cdd:PRK11551 135 RLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVgGVGPLLLVPLLMRWLPESRAFAQAAGAGKqraPVLRALF 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 211 RKPHLSISMIVFLVCFC-----LFGANWpinglLPSYLADNGVNTVVISTLMTIAGLGTLTGTIFFGFVGDKIGvkKAFV 285
Cdd:PRK11551 215 GEGRATATLLLWISYFFtlivlYFLLNW-----LPSLLVGQGLSRSQAGLVQIAFNIGGALGSLLIGALMDRLR--PRRV 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 286 VGLITSFIF--LCPLFFISVKNSSLI-----GLCLFGLMFTNLGIAGLvpkfiydYFPTKLRGLGTGLIYNLGATGGMAA 358
Cdd:PRK11551 288 VLLIYAGILasLAALAAAPSFAGMLLagfaaGLFVVGGQSVLYALAPL-------FYPTQVRGTGVGAAVAVGRLGSMAG 360
|
....
gi 90111718 359 PVLA 362
Cdd:PRK11551 361 PLLA 364
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
43-390 |
3.61e-14 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 73.36 E-value: 3.61e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 43 ADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLGMSGEYA 122
Cdd:cd17477 24 EREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 123 CASTYAVESWPKNLQSKASAFLVSGFSVGnIIAAQIIPQFAEVYGWRnSFFIG----LLPVLLVLWIRKSAPESQEwied 198
Cdd:cd17477 104 VSESWLNALATNENRGRVLGLYSTVLGLG-FALGPLLLALVGTAGAL-PFLIAavllLLALVPLLLTRRAAPEIEE---- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 199 kyKDKSTFLSVFRKPHLSismivFLVCFCLFGANWPINGLLPSYLADNGVNTVVISTLMTIAGLGTLTGTIFFGFVGDKI 278
Cdd:cd17477 178 --AESISLRRLLRIAPLA-----LLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRF 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 279 GVKKAFVV-GLITSFIFLCPLFFISVKNSSLIGLCLFGLMFT---NLGIAglvpkFIYDYFPTKLRGLGTGLIYNLGATG 354
Cdd:cd17477 251 DRRRVLLGcALLGALAALLLPLVPGLPLALLVLLFLWGGAAGplyTLALA-----LAGDRLPGDELVAANAALLLLYGLG 325
|
330 340 350
....*....|....*....|....*....|....*.
gi 90111718 355 GMAAPVLATYISGYYGlGVSLFIVTVAFSALLILLV 390
Cdd:cd17477 326 SVIGPLLAGALMDAFG-PHGLFLFLAAVALLFLLFL 360
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
49-389 |
4.77e-14 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 72.61 E-value: 4.77e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 49 DIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLGMSGEYACASTYA 128
Cdd:cd17317 24 DWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 129 VESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEvygWRNSFFIGLLPVLLVLWIrksapesqewiedkykdkstfls 208
Cdd:cd17317 104 MEIVGPKYRSFVGILFGLFWALGYMLLALLAYLIRD---WRWLQLAISLPGLLFLLL----------------------- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 209 vfrkpHLSISMIVFLVCFCLFGANWPINGLLPSylADNGVNTVVISTLmtIAGLGTLTGTIFFGFVGDKIGVKKAFVVGL 288
Cdd:cd17317 158 -----LWWLPRRTIIVGLIWFVTSLVYYGLSLN--SSNLGGNLYLNFF--LSGLVEIPAYFLALLLLDRLGRRWTLSGSL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 289 ITSFIFLCPLFFISVKNSSLIGLCLFGLMFTNLGIAGLVPKFIYDYFPTKLRGLGTGLIYNLGATGGMAAPVLATYISGY 368
Cdd:cd17317 229 LLAGLACLVTALLPDDENTLALTLALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVLLGKIG 308
|
330 340
....*....|....*....|.
gi 90111718 369 YGLGVSLFIVTVAFSALLILL 389
Cdd:cd17317 309 PLLPLIIFGVLALLGGLLTLL 329
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
22-385 |
7.37e-14 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 72.21 E-value: 7.37e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 22 LGYVFDGFDFMMIFYILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIAT 101
Cdd:cd17321 3 LAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAP 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 102 NLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSFFIGLLPVLL 181
Cdd:cd17321 83 SLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 182 VLwirksapesqewiedkykdkstFLSvfrkPHLSISMivfLVCFCLFGANWPINGLLPSYLAD-NGVNTVVISTLMTIA 260
Cdd:cd17321 163 AL----------------------LLA----RTFSGAV---LAAFLLGAALGGLLFLLPLYLQGvLGYSPLQAGLALLPL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 261 GLGTLTGTIFFGFVGDKIGVKKAFVVGLITSFIFLCPLFFISVknSSLIGLCLFGLMFTNLGIAGLVPKF---IYDYFPT 337
Cdd:cd17321 214 ALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGA--DSSVWLLLPGLVLLGLGLGLFATPLtnaALSSVPK 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 90111718 338 KLRGLGTGLI---YNLGATGGMAapVLATYISGYYGLGVSLFIVTVAFSAL 385
Cdd:cd17321 292 EKAGAASGILntaRQLGGALGVA--LLGALLTAGLSANLGDSGVAALLSAA 340
|
|
| PRK09874 |
PRK09874 |
multidrug efflux MFS transporter MdtG; |
14-301 |
9.97e-14 |
|
multidrug efflux MFS transporter MdtG;
Pssm-ID: 182127 [Multi-domain] Cd Length: 408 Bit Score: 72.26 E-value: 9.97e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 14 RKALFSAWLGYVFDGFDFMMIFYILHIIKADLGIT-----DIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIF 88
Cdd:PRK09874 13 KRNLTVAWLGCFLTGAAFSLVMPFLPLYVEQLGVTghsalNMWSGLVFSITFLFSAIASPFWGGLADRKGRKIMLLRSAL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 89 IYSVGTGLSGIATNLYMLAVCRFIVGLgMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGW 168
Cdd:PRK09874 93 GMGIVMVLMGLAQNIWQFLILRALLGL-LGGFVPNANALIATQVPRNKSGWALGTLSTGGVSGALLGPLAGGLLADSYGL 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 169 RNSFFIG-----LLPVLLVLWIRKS-APESQEwiedKYKDKSTFLSVFRKPHLSISMIVF-LVCFCLFGANWPINGLLPS 241
Cdd:PRK09874 172 RPVFFITasvlfLCFLVTLFCIRENfQPVSKK----EMLHMREVVTSLKNPKLVLSLFVTtLIIQVATGSIAPILTLYVR 247
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 90111718 242 YLADNGVNTVVISTLM-TIAGLGTLTGTIFFGFVGDKIGVKKAFVVGLITSFIFLCPLFFI 301
Cdd:PRK09874 248 ELAGNVSNIAFISGMIaSVPGVAALLSAPRLGKLGDRIGPEKILITALIFSVLLLIPMSFV 308
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
41-390 |
1.56e-13 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 71.45 E-value: 1.56e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 41 IKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLGMSGE 120
Cdd:cd17320 25 IARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 121 YACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSF-FIGLLPVLLVLWIRKSAPESQEWIEDK 199
Cdd:cd17320 105 SVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFvFLALLGLLLLLLVLLFLPETLPEEKRK 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 200 YKDKST---FLSVFRKP----HLSISMIVFLVCFClFGANWPIngllpSYLADNGVNTVVISTLMTIAGLGTLTGTIFFG 272
Cdd:cd17320 185 PLLSSLlraYKRVLKNRrflgYALALGLSFAGLFA-YLAAAPF-----IYIEQLGLSPAQFGLLFALNAIALILGSLLNG 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 273 FVGDKIGVKKAFVVGLITSFIFLCPLFFISVKNSSLIGLCLFGLMFTNLGIAGLVPKFIY---DYFPtKLRGLGTGLIYN 349
Cdd:cd17320 259 RLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSlalEPFP-HVAGTASALLGF 337
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 90111718 350 LGATGGMAAPVLATYISGYYGLGVSLFIVTVAFSALLILLV 390
Cdd:cd17320 338 LQFLIGALAGALVGLLPNGTALPMGLLILVLGLLALLLLIL 378
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
41-323 |
3.62e-13 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 70.34 E-value: 3.62e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 41 IKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLGMSGE 120
Cdd:cd17328 25 IQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASY 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 121 YACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAE-VYGWRNSFFI----GLLPVLLVLWIRKSAPESQEW 195
Cdd:cd17328 105 SPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQaTGGWRWAFRVtgvlGVLLAILLLLFVREPPRGAAE 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 196 IEDKYKDKSTFL-----SVFRKPHLSISMIVF-LVCFCLFG-ANWPINGLLPSYLADNGVNTVVISTLMTIAGLGTLTGT 268
Cdd:cd17328 185 GGVMAKSTATSFladlkALAKNPSFILSTLGFtAVSFVTGAlAFWAPTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGV 264
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 90111718 269 IFFGFVGDKIGVK----KAFV--VGLITSFIFLCPLFFISVKNSSLIGLCLFG---LMFTNLGI 323
Cdd:cd17328 265 LLGGILADRLRRKtpraDPLVcaVGLLAAAPFLFLALVLALSNLLLAWVLLFLgefLLSLNWAP 328
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
26-392 |
5.73e-13 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 69.93 E-value: 5.73e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 26 FDGFDFMMIFYILHIIKADLGITdiqATLIGTVAFIARPIGGG---FFGAMADKYG-----RKPMMMWAIFIYSVGTGL- 96
Cdd:COG2211 22 LNLAFGLLSAYLLYFYTDVLGLS---AALVGLILLVARLWDAItdpLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLl 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 97 -----SGIATNLYMLAVCRFIVGLGMSGEYACASTYAVE-SWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVY---- 166
Cdd:COG2211 99 ftapdLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAElTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFggda 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 167 --GWRNSFFI-GLLPVLLVLWIRKSAPESQEWIEDKYKDKSTFLSVFRKPHLsisMIVFLVCFCLFGANWPINGLLPSYL 243
Cdd:COG2211 179 alGYRLTALIfAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLKNRPF---LLLLLAYLLFFLALALVAALLLYYF 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 244 ADN-GVNTVVISTLMTIAGLGTLTGTIFFGFVGDKIGVKKAFVVGLITSFIFLCPLFFISVKNSSLIGLCLFGLMFTNLG 322
Cdd:COG2211 256 KYVlGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGA 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 323 IAGLVPKFI-----YDYFPTKLR--GLGTGLIYNLGATGGMAAPVLATYISGYYG--------------LGVSLFIVTVA 381
Cdd:COG2211 336 ILVLPWAMLadvvdYDEWKTGRRreGLYFGIFTFAIKLGQALAGALAGLLLALFGyvagaaqspsaltgIRLLFFLLPAV 415
|
410
....*....|.
gi 90111718 382 FSALLILLVGF 392
Cdd:COG2211 416 LLLLAALLLLF 426
|
|
| PRK10406 |
PRK10406 |
alpha-ketoglutarate transporter; Provisional |
60-348 |
6.36e-13 |
|
alpha-ketoglutarate transporter; Provisional
Pssm-ID: 182433 [Multi-domain] Cd Length: 432 Bit Score: 69.84 E-value: 6.36e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 60 FIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGT-------GLSGIAT-NLYMLAVCRFIVGLGMSGEYACASTYAVES 131
Cdd:PRK10406 73 FLMRPIGGWLFGRIADKHGRKKSMLISVCMMCFGSlviaclpGYETIGTwAPALLLLARLFQGLSVGGEYGTSATYMSEV 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 132 WPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEV--------YGWRNSFFIGLLPVLLVLWIRKSAPESQEWIEDKYKDK 203
Cdd:PRK10406 153 AVEGRKGFYASFQYVTLIGGQLLALLVVVVLQQTledaelreWGWRIPFALGAVLAVVALWLRRQLDETSQQETRALKEA 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 204 STFLSVFRKPHLSISMIVFL----VCFCLFganwpiNGLLPSYLADN-GVNTVVISTLMTIAGLGTLTGTIFFGFVGDKI 278
Cdd:PRK10406 233 GSLKGLWRNRRAFIMVLGFTaagsLCFYTF------TTYMQKYLVNTaGMHANVASGIMTAALFVFMLIQPLIGALSDKI 306
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 90111718 279 GVKKAFVVGLITSFIFLCPLFFISVKNSS---LIGLCLFGLMFTNL--GIAGLVPKfiyDYFPTKLRGLGTGLIY 348
Cdd:PRK10406 307 GRRTSMLCFGSLAALFTVPILSALQNVSSpyaAFGLVMCALLIVSFytSISGILKA---EMFPAQVRALGVGLSY 378
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
16-346 |
8.85e-13 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 69.13 E-value: 8.85e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 16 ALFSAWLGYVFdGFDFMMIFYILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTG 95
Cdd:cd17359 3 SLVAALGGLLF-GYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 96 LSGIATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAF----LVSGFSVGNIIAAQIIPQFAEVY----G 167
Cdd:cd17359 82 GSAFSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLnqlmIVFGQLLAYIVNYLIANAGGADWlgaeG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 168 WRNSFFIGLLPVLLVLWIRKSAPESQEWiedkykdkstfLSVFRKPHLSISmivflVCFCLFGANWPINGLL---PSYLA 244
Cdd:cd17359 162 WRWMLGLEAIPAILFLLGMLFIPESPRW-----------LVSKGKPILIIG-----IGLAIFQQFVGINVIFyygPEIFQ 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 245 DNGVNTVViSTLMTIA-GLGTLTGTIFFGFVGDKIGVKKAFVVGLI--TSFIFLCPLFFISVKNSS------LIGLCLFg 315
Cdd:cd17359 226 NAGFSENA-ALLQTIGiGVVNVIFTIIAILLVDKVGRKPLLLIGSIgmAISLLLIGTAFYFAPGSQasgivaLVLILLF- 303
|
330 340 350
....*....|....*....|....*....|.
gi 90111718 316 LMFTNLGIAGLVPKFIYDYFPTKLRGLGTGL 346
Cdd:cd17359 304 VAFFAMSWGPVTWVLLSEIFPNRIRGLAMGI 334
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
52-390 |
5.43e-12 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 66.92 E-value: 5.43e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 52 ATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATN------LYMLAVCRFIVGLGMSGEYACAS 125
Cdd:cd17364 41 SGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGstplgvMGWLIFFRFLLGIGIGGDYPLSA 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 126 TYAVES----WPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEV----------YGWRNSFFIGLLPVLLVLWIRKsape 191
Cdd:cd17364 121 TIMSEYankkRRGALIAAVFAMQGFGILAGAIVTLILSAIFEHPlpagtyhhadLVWRIVLGLGAIPALSVLYFRK---- 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 192 sqewiedkykdkstflsvfrkpHLSISMIV-FLVCFCLFGANW-------PINGLLPSYLADNGVNTVVISTLmtIAGLG 263
Cdd:cd17364 197 ----------------------HLLGTAGTwFLLDIAFYGQNLfqstiisAIGFSKTMNAYQELFNIAVGQLI--IALAG 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 264 TLTGTIFFGFVGDKIGVKKAFVVGLITSFIFL----CPLFFISVKNSSLIGLCLFGLMFTNLG---IAGLVPKFIydyFP 336
Cdd:cd17364 253 TVPGYWFTVFLIDRIGRKKIQMMGFFGMTIFLlilaGPYDHWKISTIGFFVLYGLTFFFSNFGpntTTFIVPAEV---FP 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 90111718 337 TKLRGLGTGLIYNLGATGGMAAPVLATYISGYYGLGVSLFIVTVA--FSALLILLV 390
Cdd:cd17364 330 ARVRSTCHGISAASGKIGAIVGSFLFLSLTQNIGVRNVLIILAGValLGIILTLLF 385
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
41-368 |
6.30e-12 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 66.45 E-value: 6.30e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 41 IKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLGMSGE 120
Cdd:cd17503 22 IMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 121 YACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSFFIGLLPVLLVLWIRKSAPesqewiedky 200
Cdd:cd17503 102 IPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPLLD---------- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 201 kdkstfLSVFRKPHLSISMI-VFLVCFCLFGANWpingLLPSYLADN-GVNTVVISTLMTIAGLGTLTGTIFFGFVGDKI 278
Cdd:cd17503 172 ------LRLFKDRNFTLGLLlSFLLGLGLFGAMF----LLPLYLQNVlGYSAFESGLVLAPGGLASAILSPLVGRLLDKF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 279 GVKKAFVVGLITSFIFLCPLFFISVKNS--------SLIGLCLFGLM--FTNLGIAGLvpkfiydyfPTKLRGLGTGL-- 346
Cdd:cd17503 242 GPRLLLLAGLLLLALGTLLLAFLTPDTSlwliilplFIRGLGMGLVFmpLNTLALNSL---------PPEQIGDATALfn 312
|
330 340
....*....|....*....|...
gi 90111718 347 -IYNLGATGGMAapVLATYISGY 368
Cdd:cd17503 313 tIRQLGGSIGTA--LLATLLTNR 333
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
13-390 |
6.55e-12 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 66.53 E-value: 6.55e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 13 QRKALFSAWLGYVFDGFDFMMIFYILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSV 92
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 93 GTGLSGIATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSF 172
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 173 FIGLLPVLLVlwirksapesqewiedkykdkSTFLSVFRKPHLSISMIVFLVCFCLFGANWPINGLLPSYLADN-GVNTV 251
Cdd:cd17312 161 LVPGIVGLVV---------------------AIILFFFLRDSPPYVWVLSLAYAFVYIVRYACLDWGPLYLYEVkGYSLI 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 252 VISTLMTIAGLGTLTGTIFFGFVGDKIGVKKAFVVGLITS--FIFLCPLFFISVKNSSLIGLCLFGLMFTNLGIAGLVPK 329
Cdd:cd17312 220 DAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAVIYMllMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPINLIGG 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 90111718 330 FIYDYFPTKlRGLGT-----GLIYNLGAtgGMAAPVLATYISGYYGLGVSLF-IVTVAFSALLILLV 390
Cdd:cd17312 300 AAAQDIGRK-EAAGTatgfvGLFGYLGA--SLAGLPLGYIIDHYGWSTVFYFlISAALLSVLLLLSL 363
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
54-392 |
1.11e-11 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 65.71 E-value: 1.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 54 LIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIAT-----NLYMLAVCRFIVGLGMSGEYACASTYA 128
Cdd:cd06173 38 LVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLAllgslSLWLLLVLAFLLGIASAFFGPARQALL 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 129 VESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSFFIG----LLPVLLVLWIRKSAPESQ-EWIEDKYKDK 203
Cdd:cd06173 118 PELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINalsfLLSALLLLFIRRPPPAAPgESSSLLLRDL 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 204 STFLSVFRKPHLSISMIVFLVCFCLFGAnwPINGLLPSYLADN-GVNTVVISTLMTIAGLGTLTGTIFFGFVGDKIGVKK 282
Cdd:cd06173 198 REGLRYLRRSPLLRLLLLALALFALLGG--ALTVLLPLLAKEVlGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGR 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 283 AFVVGLITSFIFLCPLFFISVKNSSLIGLCLFGLMFTNLGIAGLVpkFIYDYFPTKLRGLGTGLIYNLgatgGMAAPVLA 362
Cdd:cd06173 276 LLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNT--LLQLRVPDELRGRVFSVYNAL----NSGAMPLG 349
|
330 340 350
....*....|....*....|....*....|
gi 90111718 363 TYISGYYGLGVSLFIVTVAFSALLILLVGF 392
Cdd:cd06173 350 ALLAGLLADALGLSAVFLLAGALLLLAALL 379
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
40-390 |
1.92e-11 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 64.95 E-value: 1.92e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 40 IIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMmwaiFIYSVGTGLSGI----ATNLYMLAVCRFIVGL 115
Cdd:cd17475 21 FLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVL----AVGLLLMGAAALlmalVGSYPVLLVLLFLVGA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 116 GMSGEYAcASTYAVESW-PKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSFFIGLL-----PVLLVLWIRKSA 189
Cdd:cd17475 97 GYGSVQP-GGGRAIMRWfPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLvsilaAVLFWLFYREPP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 190 PESQEwiedkyKDKSTFLSVFRKPHLSISMI--VFLVCFCLFGANWPINGLLPSYLADN-GVNTVVISTLMTIAGLGTLT 266
Cdd:cd17475 176 AASAA------TESASTLLRSLKEVLRNRDVwlIAIAGALLVAPQFALLTFLLLFLHDHlGLSVVAAGALLAVAQLGGAL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 267 GTIFFGFVGDKIGVKKAFVVGLITSFI----FLCPLFFISVKNSSLIGLCLFGLMFTNLGIAGLVPKFIYDYFPTKLRGL 342
Cdd:cd17475 250 GRIGLGRVSDRVFGGRRRPVLVITAAIaaaaLLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGT 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 90111718 343 GTGliynLGATGGMAAPVLATYISGYYGLGVSLFIVTVAFSALLILLV 390
Cdd:cd17475 330 ALG----LANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLA 373
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
51-392 |
3.48e-11 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 64.65 E-value: 3.48e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 51 QATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLGMSGEYACASTYAVE 130
Cdd:TIGR00898 128 KVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTE 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 131 SWPKNLQSKASAFLVSGFSVGNIiaaqIIPQFA-EVYGWRNSFFIGLLP----VLLVLWIrksaPESQEWI--------- 196
Cdd:TIGR00898 208 FLPKKQRAIVGTLIQVFFSLGLV----LLPLVAyFIPDWRWLQLAVSLPtflfFLLSWFV----PESPRWLisqgrieea 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 197 ---------------------------EDKYKDKSTFLSVFRKPH-----LSISMIVFLVCFCLFGanwpinglLPSYLA 244
Cdd:TIGR00898 280 lkilqriakingkklpaevlslslekdLSSSKKQYSFLDLFRTPNlrkttLCLMMLWFTTAFSYYG--------LVLDLG 351
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 245 DNGVNTVVISTLMtiaGLGTLTGTIFFGFVGDKIGVKKAFVVGLITSFIFLCPLFFISVKNSSLI-GLCLFGLMFTNlgi 323
Cdd:TIGR00898 352 NLGGNIYLDLFIS---GLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFVPVDLYFLRtALAVLGKFGIT--- 425
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 90111718 324 AGLVPKFIY--DYFPTKLRGLGTGLIYNLGATGGMAAPVLAtyisgyYGLGVSLFIVTVAFSALLILLVGF 392
Cdd:TIGR00898 426 SAFQMVYLYtaELYPTVVRNLGVGVCSTMARVGSIISPFLV------YLGEKWLFLPLVLFGGLALLAGIL 490
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
43-389 |
6.42e-11 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 63.37 E-value: 6.42e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 43 ADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLGMSGEYA 122
Cdd:cd17330 27 NKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 123 CASTYAVESWPKNlQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSFFIGLLPVLLVLwirksapesqewiedkykd 202
Cdd:cd17330 107 AQAYIADITDEEE-RAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNL------------------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 203 kstFLSVFRKPHLSISMIVFLVCFCLFGANWPInglLPSYLADN-GVNTVVISTLMTIAGLGTLTGTIFF-GFVGDKIGV 280
Cdd:cd17330 167 ---VLVLFFLPPLRRLLLVYFLIALAFAGLESV---FSLFLKDRfGFSPSQIGLLLALVGIAGILAQLLLiPRLAKRLGE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 281 KKAFVVGLITSFIFLCPLFFISVKNSSLIGLCLFGLM--FTNLGIAGLVPKfiydYFPTKLRGLGTGLIYNLGATGGMAA 358
Cdd:cd17330 241 RKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGtgIVFPALSALLSK----SVPSKEQGKAQGIIQSLQSLARIIG 316
|
330 340 350
....*....|....*....|....*....|.
gi 90111718 359 PVLATYISGYYGLGVSLFIVTVAFSALLILL 389
Cdd:cd17330 317 PLLAGPLYSFLGPGVPFLLAAGLLLIALFLL 347
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
41-370 |
9.98e-11 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 62.78 E-value: 9.98e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 41 IKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLGMSGE 120
Cdd:TIGR00881 21 LVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 121 YACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIP-QFAEVYGWRNSFF----IGLLPVLLVLWIRKSAPES--- 192
Cdd:TIGR00881 101 WPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLfGIAELYSWHWVFIvpgiIAIIVSLICFLLLRDSPQScgl 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 193 ----QEWIEDKYKDKSTFLSVFRKPHLSISMIVF-----LVCFC---LFGANWPINGLLPSYLAD-NGVNTVVISTLMTI 259
Cdd:TIGR00881 181 ppaeEMPNEEPDGDAEKKEEELTKKQIFLQYVLLnkvlwYISLGyvfVYVVRTGILDWSPLYLTQeKGFSKEKASWAFTL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 260 AGLGTLTGTIFFGFVGDKIGVKKAFVVGLI-TSFIFLCPLFF--ISVKNSSLIGLCLFGLMFTNLGIAGLVPKFIYDYFP 336
Cdd:TIGR00881 261 YELGGLVGTLLAGWLSDKLFNGRRGPLAVFfMALIIVSLLVYwlNPAANPLMDLICLFALGFLVYGPQMLIGVIASELAP 340
|
330 340 350
....*....|....*....|....*....|....
gi 90111718 337 TKLRGLGTGLIYNLGATGGMAAPVLATYISGYYG 370
Cdd:TIGR00881 341 KKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
18-347 |
1.42e-10 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 62.29 E-value: 1.42e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 18 FSAWLGYVFdGFDFMMIFYILHIIKADLG---ITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGT 94
Cdd:cd17360 1 FAGIGGFLF-GYDTGVISGALLYIKDDLGevvLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 95 GLSGIATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQskasAFLVSGFSV----GNIIAAQIIPQFAEVY-GWR 169
Cdd:cd17360 80 IVMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIR----GRLVTINVLfitgGQFVAYVINGAFSYLPgGWR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 170 NSFFIGLLPVLLVLWIRKSAPESQEWiedkykdkstfLSVFRKPHLSISMIVFLVcfcLFGanwpINGLL---PSYLADN 246
Cdd:cd17360 156 WMLGLAAVPAVLQFIGLLFLPESPRW-----------PSTRRALIVGCGLQAFQQ---FSG----INTVMyysATILQMA 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 247 GVNTVVISTLMTIAGLGT-LTGTIFFGFVGDKIGVKKAFvvgLITSFIFLCPLFFISVkNSSLIGLCLFgLMFTNLGIaG 325
Cdd:cd17360 218 GFKDNQNAIWLSLIVAGTnFIFTIVGMYLIDKFGRRKLL---LISLFGVIVALVVLAV-WLALVGLILY-LAFFAPGM-G 291
|
330 340
....*....|....*....|...
gi 90111718 326 LVPKFI-YDYFPTKLRGLGTGLI 347
Cdd:cd17360 292 PVPWTVnSEIYPLWARGTGGGCA 314
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
40-392 |
1.59e-10 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 62.27 E-value: 1.59e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 40 IIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLY-MLAVCRFIVGLGmS 118
Cdd:cd17341 24 VIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVSSYwGLLVLGFLLGFA-G 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 119 GEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAE-------VYGWRNSFFIGLLP----VLLVLWIRK 187
Cdd:cd17341 103 ANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGaivfdggFVGWRNAFFVPGILlaiaAVLVLLFGD 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 188 SAPESQEWIEDKYKDkstFLSVFRKPHLSISMIVFLVCFCLFGAnwpINGLLPSYLADN-GVNTVVISTLMTIAGLGTLT 266
Cdd:cd17341 183 DLPTGKASALEFLKV---QLAVLKNYRTWILSLLYGVTFGSFVG---FSNVLPTYFKTRfGLPLVTAGILAALFPLAGAL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 267 GTIFFGFVGDKIGVKKAFVVGLITSFIFLCPLFFISVKNSSLIGLCL---FGLMFTNLGIAGLVPKFIYDYFPTKLrGLG 343
Cdd:cd17341 257 ARPAGGWLSDRFGGRRRLWWLFIVMTIGAALLSLSLPTSGTNLVLFLalfVALGLGAGAGNGSVFRMVPFIFRREL-GAV 335
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 90111718 344 TGLIYNLGATGGMAAPVLATYISGYYGLGVSLFIVTVAFSALLILLVGF 392
Cdd:cd17341 336 TGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVACTLLVWL 384
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
41-328 |
6.33e-10 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 60.48 E-value: 6.33e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 41 IKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLGMSGE 120
Cdd:TIGR00710 31 IAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 121 YACASTYAVESWPKNLQSKASAFLVSGFS----VGNIIAAQIIPQFaevyGWRNSF-FIGLLPVLLVLWIRKSAPES--Q 193
Cdd:TIGR00710 111 SVISQALVRDIYPGEELSRIYSILMPVLAlapaVAPLLGGYILVWL----SWHAIFaFLSLAGILLSALIFFILPETlpY 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 194 EWIEDKYKDKSTFLSVFRKPHLSISMIVFLVCFCLFGANWPINGLLpsYLADNGVNTVVISTLMTIAGLGTLTGTIFFGF 273
Cdd:TIGR00710 187 EARIQISTYFETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFV--YIDIMGVSPSVFGLLFALNIIAMIFGGFLNGR 264
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 90111718 274 VGDKIGVKKAFVVGLITSFIFLCPLFFISVKNSSLIGLCLFGLMFTNLGIAGLVP 328
Cdd:TIGR00710 265 FIKKWGAKSLLRMGLILFAVSAVLLEITAILGLGSWAMIIGPMMFVGIGNSMISS 319
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
220-395 |
7.16e-10 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 59.99 E-value: 7.16e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 220 IVFLVCFCLFGANWPINGLLPSYLADNGVNTVVISTLMTIAGLGTLTGTIFFGFVGDKIGVKKAFVVGLITSFIFLCPLF 299
Cdd:COG2814 14 ALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 300 FISVKNSSLIGLCLFGLMFTnlGIAGLVPKFIYDYFPTKLRGLGTGLIYNLGATGGMAAPVLATYISGYYGLGvSLFIVT 379
Cdd:COG2814 94 LAPSLWLLLAARFLQGLGAG--ALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWR-WVFLVN 170
|
170
....*....|....*.
gi 90111718 380 VAFSALLILLVGFDIP 395
Cdd:COG2814 171 AVLALLALLLLLRLLP 186
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
16-390 |
1.42e-09 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 59.35 E-value: 1.42e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 16 ALFSAWLGYVFDGFDFMMIFYILHIIKA---DLGITDIQATLIGTVAFIARPIGGGFfgamADKYGRKPMMMWAIFIYSV 92
Cdd:cd17314 5 LYVSFLLSAMSTGFILSWSLFYQPWQDAfgySSSQIATAASLSNLGMLLTQPILGFI----ADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 93 GTGLSGIATNLYMLA-VCRFIVGLGMSGEYACASTYAVESWPKNlQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNS 171
Cdd:cd17314 81 GYTYLSYVFNSFPLSyACFVFIGAGTGILYGSAVLVTTQYFPDT-KGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 172 F-------FIGLLPVLLVLWIRKSAPESQEWIEDKYKDKSTFLsvFRKPHLSISMIV-FLVCFCLFGANWPINGLLPSYl 243
Cdd:cd17314 160 YtilgilaAIVLSVVSLLGFKEPPDNQARLHVQKKKTQTMGEI--FRDKVFWILFIAiFLVLIGGFLFIANMASLVRSL- 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 244 adNGVNTVVISTLMTIAGLGTLTGTIFFGFVGDKIG--VKKAFVVGLITSFIFLCPLFFISVKNSSLIGL-CLFGLMFTN 320
Cdd:cd17314 237 --QLDAPSFVTKLMSIYGLFNAFGRLLWGIVADFFGgrLSTLSILLTILGLGLCAFLFLLKMTPVGLVLTgSLLGFSYGG 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 90111718 321 LGIagLVPKFIYDYFPTKLRGLGTGLIYNLGATGGMAAPVLATYI---SGYYGLGVSLFIVTVAFSALLILLV 390
Cdd:cd17314 315 LFT--VYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFydrTPSYISAVYIYAVIVFLASAILLAV 385
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
30-390 |
1.56e-09 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 59.26 E-value: 1.56e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 30 DFMMIFYILHIIKAdLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVC 109
Cdd:cd17333 12 DALLGILGPSLEEA-FNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 110 RFIVGLGMSGEYACASTYAVESWPKNlQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSFFIGLLPVLLVLWIR--- 186
Cdd:cd17333 91 MFLAGLGAGILDTGANTFVGALFEES-SATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAILill 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 187 ---KSAPESQEWIEDKYKDKSTFLSVFRKPHLSISMIVFlvcFCLFGANWPINGLLPSYLADN-GVNTVVISTLMTIAGL 262
Cdd:cd17333 170 tlfPELPSARNPQQSVGAFSASASRLLRNPSIILGALAL---FLYVGAETAFSSWVPSYLVEKkHVSDGLAGYLLSGFWV 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 263 GTLTGTIFFGFVGDKIGVKKAFVVGLITSFIFlcplFFISVKNSSLIGLcLFGLMFTNLGIAGLVPKFIYDY--FPTKLR 340
Cdd:cd17333 247 GITIGRLLGGPISRRIKPHTLLVLSGSGALLG----LLILLLAPTLVVG-LVATALLGLFMAALFPTILSLGisNLPYAK 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 90111718 341 GLGTGLIYNLGATGGMAAPVLATYISGYYGLGVSLFIVTVAFSALLILLV 390
Cdd:cd17333 322 GKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLAL 371
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
22-385 |
2.99e-09 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 58.31 E-value: 2.99e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 22 LGYVFDGFDFMMIFYILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIAT 101
Cdd:cd17372 6 MGWVAEAMEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAP 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 102 NLYMLAVCRFIVGLGMSGEYACASTYAvESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSFFIGLLPVLL 181
Cdd:cd17372 86 NYMWLIILRCLVGLGLGGGPQLASWYL-EFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLGWRWLLAFSSVPSSL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 182 VLWIRKSAPES--QEWIEDKYKDKSTFLSVFRKPHLSISMIVFLVCFCLFGANWPINGLLpSYLADNGVNTVVISTLMTI 259
Cdd:cd17372 165 LLVFYRWTPKTtlLLWVIWFGNAFAYYGVVLLTTELNNSHNVCGSKSDSDSGESPTEKQC-RNSNDVDYRDVFIATFAEF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 260 AGLGTLTGTIffgfvgDKIGVKKAFVVGLITSFIFLCPLfFISVKNSSLIGLCLFGLMFTNlgiAGLVPKFIY--DYFPT 337
Cdd:cd17372 244 PGLLISAAMI------DRLGRKASMASMLFTCCIFLLLL-LICQSPFILTVLLFGGRACIS---AAFTVVYIYtpEVYPT 313
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 90111718 338 KLRGLGTGLIYNLGATGGMAAPVLAT-YISGYYGLGVSLFIVTVAFSAL 385
Cdd:cd17372 314 AVRALGVGTGSSVGRIGAILCPFIAQvLVHGSQTIALLLFSVVCLVSAI 362
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
221-397 |
4.73e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 57.43 E-value: 4.73e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 221 VFLVCFCLFGANWPINGLLPSYLADN-GVNTVVISTLMTIAGLGTLTGTIFFGFVGDKIGVKKAFVVGLITSFIFLCPLF 299
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDlGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 300 FISVKNSSLIGLCLFGLMFTNLGIAGLVpkFIYDYFPTKLRGLGTGLIYNLGATGGMAAPVLATYISGYYGLGVSLFIVT 379
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALA--LIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILA 158
|
170
....*....|....*...
gi 90111718 380 VAFSALLILLVGFDIPGK 397
Cdd:pfam07690 159 ILSLLAAVLLLLPRPPPE 176
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
65-183 |
8.36e-09 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 53.81 E-value: 8.36e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 65 IGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFL 144
Cdd:TIGR00880 13 IYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPEERGVALGLM 92
|
90 100 110
....*....|....*....|....*....|....*....
gi 90111718 145 VSGFSVGNIIAAQIIPQFAEVYGWRNSFFIGLLPVLLVL 183
Cdd:TIGR00880 93 SAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAF 131
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
28-193 |
8.53e-09 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 56.81 E-value: 8.53e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 28 GFDFMMIFYILHIIKADLGITD--IQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYM 105
Cdd:cd17315 10 GYDLGVINGALLYIAKDLGFGLstSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 106 LAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGnIIAAQIIPQFAEVY---GWRNSFFIGLLPVLLV 182
Cdd:cd17315 90 LIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFG-ILLAYLLGLALSLSppgWWRLMFALAAVPALLQ 168
|
170
....*....|.
gi 90111718 183 LWIRKSAPESQ 193
Cdd:cd17315 169 LLLMFFLPESR 179
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
70-392 |
1.09e-08 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 56.46 E-value: 1.09e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 70 FGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLGMSGeyACASTYAVESWPKNLQSKASAFLVSGFS 149
Cdd:cd17472 52 FGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGAIS--SVVMALLADLTREENRTKAMALIGASIG 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 150 VGNIIAAQIIPQFAEVYGWRNSF----FIGLLPVLLVLWIRKSAPESQEWIEDKYKDKSTFLsvFRKPHLSISMIVFLVC 225
Cdd:cd17472 130 IAFAISMVLGPLLAAHLGVSGLFlitaILSLVSLLILLFFVPDPPKIVQISEKEKKKLKKLL--KNKRLLRLDFSIFILH 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 226 FCLFgANWPInglLPSYLADNGVNTVVISTLMTIAGLGTLTGTIFFGFVGDKIGVKKAFVVGLITSFIFLCPLFFISVKN 305
Cdd:cd17472 208 FVLM-AFFYI---LPLLLTQLGGGKGQLWKVYLPAILIGFILMVPFVIYAEKKGKMKQVFVSSILLIAVGFLLLLFAATS 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 306 SSL--IGLCLF--GLMFTNLGIAGLVPKFIydyfPTKLRGLGTGLIYNLGATGGMAAPVLATYISGYygLGVSLFIVTVA 381
Cdd:cd17472 284 LWLliIGLIIFfiGFNLLEALLPSLVSKIA----PKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGL--LGYSSVFLTIL 357
|
330
....*....|.
gi 90111718 382 FSALLILLVGF 392
Cdd:cd17472 358 ILALLWLLVSF 368
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
21-231 |
1.38e-08 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 56.03 E-value: 1.38e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 21 WLGYVFDGFDFMMIFYILHIIKADLGITDiQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIA 100
Cdd:cd17502 2 MLALFLAALDQTIVATALPTIVAEFGGLS-LVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 101 TNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSFFIGLLPVL 180
Cdd:cd17502 81 PNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIGG 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 90111718 181 LVLWIRKSApesqewiedkykdkstflsvfrkphLSISMIVFLVCFCLFGA 231
Cdd:cd17502 161 LALALLRTI-------------------------LLSSIFGFLFGGALFGL 186
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
221-392 |
2.37e-08 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 55.51 E-value: 2.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 221 VFLVCFCLFGANWPINGLLPSYLADNGVNTVVISTLMTIAGLGTLTGTIFFGFVGDKIGVKKAFVVGLITSFIFLCPLFF 300
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 301 ISVKNSSLIGLCLFGlmFTNLGIAGLVPKFIYDYFPTKLRGLGTGLIYNLGATGGMAAPVLATYISGYYGLGVSLFIVTV 380
Cdd:cd06174 81 APSFWLLLLGRFLLG--LGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIA 158
|
170
....*....|..
gi 90111718 381 AFSALLILLVGF 392
Cdd:cd06174 159 AALALLAAILLL 170
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
18-175 |
3.16e-08 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 55.75 E-value: 3.16e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 18 FSAWLGYVFDGFDFMMIFYILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLS 97
Cdd:TIGR01299 170 FVLGLALMADGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFFAFFS 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 98 GIATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAA----QIIPQfaevYGWrnSFF 173
Cdd:TIGR01299 250 SFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGGIYAAamawAIIPH----YGW--SFQ 323
|
..
gi 90111718 174 IG 175
Cdd:TIGR01299 324 MG 325
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
40-176 |
4.91e-08 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 54.50 E-value: 4.91e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 40 IIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLGMSG 119
Cdd:cd17323 24 QIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSS 103
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 90111718 120 EYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSFFIGL 176
Cdd:cd17323 104 PLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
82-390 |
5.33e-08 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 54.54 E-value: 5.33e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 82 MMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQ 161
Cdd:cd17485 71 PTQLGLALLLLALAFLPPTTNLLAFLGLLFLLNLFSATQDIATDGLAVELLTPEERGLGNAAQVVGYKLGSLLGGGGLLW 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 162 FAEVYGWRNSF-----FIGLLPVLLVLWIRKSAPESQEWIEDKYKDKSTFLSVFRKPHLsISMIVFLVCFCLFGAnwPIN 236
Cdd:cd17485 151 LYDLIGWQSLLlslaaLYLLLLLPVLFLRELELPQQPPASERGAALKASLRAFLRRPGT-RWLLLFLLLYKLGEQ--GAL 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 237 GLLPSYLADNGVNTVVISTLMTIAGLGT-LTGTIFFGFVGDKIGVKKAFVVGLITSFIFLCPLFFISVKNSSLIGLCLFG 315
Cdd:cd17485 228 AMLPPFLVDRGFSLSQIGLLSGVGGSLVsIAGSLLGGYLLKRRGRRRLLLLGGLLRLLLLGLYTLLALGGSGLNWVLLLA 307
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 90111718 316 LMFTNLGIAGLVPKFIYDYFPTKLRGLGTGLIYNLGAT----GGMAAPVLATYISGYYGLGVsLFIVTVAFSALLILLV 390
Cdd:cd17485 308 SLALLHLVGGMITTALFTLMMDCSQQAQAGTDYTLLATvevlGKLLFGSLAGFLADHLGYAA-AFLLFAILSALSVLLL 385
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
44-346 |
5.66e-08 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 54.50 E-value: 5.66e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 44 DLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLGMSGEYAC 123
Cdd:cd17358 35 SLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASVV 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 124 ASTYAVESWPKN----LQSKASAFLVSGFSVGNIIAAQIipqfaevyGWRNSFFIGLLPVLLVL-----------W---- 184
Cdd:cd17358 115 VPVYIAEIAPKNvrgaLGSLNQLLVNIGILLGYVLGSFL--------PWRTLALIGAIPPVVFLillffipesprWlakk 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 185 -------------------IRKSAPESQEWIEDKYKD--KSTFLSVFRKP--HLSISMIVFLVCFCLFGANWPINGLlpS 241
Cdd:cd17358 187 greeeaekslqflrgkdadISKEAAEIQEELAELEKEakESSFSDLFQRKylKPLVIGLGLMLFQQLSGINAVIFYA--S 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 242 YLADNGVNTVVISTLMTIAGLGTLTGTIFFGFVGDKIGVKK--------AFVVGLITSFIFLCPLFFISVKNSS---LIG 310
Cdd:cd17358 265 SIFDEAGSGLDPNTATIIIGVVQVVGTLVATLLVDRLGRRPlllvsaigMGIGLLALGLYFYLQEHGALLSSVSwlpLVG 344
|
330 340 350
....*....|....*....|....*....|....*.
gi 90111718 311 LCLFGLMFtNLGIAGLVPKFIYDYFPTKLRGLGTGL 346
Cdd:cd17358 345 LVIYIISF-SIGLGPLPWVIMSEIFPAKIKGLAGSL 379
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
211-392 |
7.71e-08 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 53.72 E-value: 7.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 211 RKPHLSISMIVFLVCFCLFGANWPINGLLPSYLADNGVNTVVISTLMTIAGLGTLTGTIFFGFVGDKIGVKKAFVVGLIT 290
Cdd:COG2271 5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 291 SFIFLcpLFFISVKNSSLIGLCLFGLMFTNLGIAGLVPKFIYDYFPTKLRGLGTGLIYNLGATGGMAAPVLATYISGYYG 370
Cdd:COG2271 85 WGLAT--LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG 162
|
170 180
....*....|....*....|..
gi 90111718 371 LGVSLFIVTVAfsALLILLVGF 392
Cdd:COG2271 163 WRAAFLILGLP--GLLLALLRF 182
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
67-387 |
1.18e-07 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 53.42 E-value: 1.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 67 GGFFGAM-----ADKYGRKPMMMWAIFIYSVG---TGLSGIATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQS 138
Cdd:cd17357 61 GGAIGSFisaflANRFGRKNGLLISNALLVVSsllMFLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEISPSELRG 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 139 KASAFLVSGFSVGNIIAAQI-IPQ-FAEVYGWRNSFFIGLLPVLLVLWIRKSAPESQEWIEDKYKDKS------------ 204
Cdd:cd17357 141 ALGSLTQIGVTLGILLGQVFgLPSvLGTETLWPYLLFFPGIPALLQLAALPFFPESPKFLLISKGDEEeaekslkflrgi 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 205 ------------------------TFLSVFRKP--HLSISMIVFLVCFCLFGANWPINGLLPSYLADNGVNTVVISTLMT 258
Cdd:cd17357 221 eddvdqeleeikkeseqmgdqkqvSLMQLLRDPslRLPLLLVLVVSASQQFSGINAIFFYSTFIFENAGFSPQLAEWANL 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 259 IAGLGTLTGTIFFGFVGDKIGVK----KAFVVGLITSFIFLCPLFFIS----VKNSSLIGLCLFGlMFTNLGIaGLVPKF 330
Cdd:cd17357 301 GIGIVNVLSTIVGPFLIEKVGRRplllISLSVCAVALLLMSVFLFLSEqnswMSYGCIVAIFLFI-FFFAIGL-GPIPWF 378
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 90111718 331 I-YDYFPTKLRGLGTGLIYNLGATG----GMAAPVLATYISGYYGLgvsLFIVTVAFSALLI 387
Cdd:cd17357 379 IgAELFPQAPRSAAQSLGSSVNWTSnfivGMAFPPLQSIGGGFVFI---IFAIPCALFLLYL 437
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
71-190 |
1.45e-07 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 52.94 E-value: 1.45e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 71 GAMADKYGRKPMMMWAIFIYSVGTGLSGIA--TNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGF 148
Cdd:cd17380 55 GYLADRFGGKKVLLLAVALWSLATLLTPLLaySSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGS 134
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 90111718 149 SVGNIIAAQIIPQFAEVYGWRNSF-FIGLLPVL-LVLWIRKSAP 190
Cdd:cd17380 135 YLGTLLGGLIGPLLLEYYGWPSVFyFFGLLGLLwALVWLIYLPP 178
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
215-392 |
1.72e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 52.96 E-value: 1.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 215 LSISMIVFLVCFCLFGAnWPIngLLPSYLADNGVNTVVISTLMTIAGLGTLTGTIFFGFVGDKIGVKKAFVVGLITSFIf 294
Cdd:COG2223 7 LLLATLAFFLAFGVWYL-WSV--LAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 295 lcPLFFISVKNSsLIGLCLFGLMFTNLGIAGLVP--KFIYDYFPTKLRGLGTGLIYNLGATGGMAAPVLATYISGYYGLG 372
Cdd:COG2223 83 --GLLLLALAVS-YWLLLLLGLLLGIGGGGSFAVgiALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWR 159
|
170 180
....*....|....*....|
gi 90111718 373 VSLFIVTVAFSALLILLVGF 392
Cdd:COG2223 160 NAFLILGILLLVVAVLAWLF 179
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
31-389 |
1.85e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 52.61 E-value: 1.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 31 FMMIFYILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCR 110
Cdd:cd17329 16 FMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIAL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 111 FIVGLGMSGEYACASTYAVESWPKNLQSKA----SAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSFFIGLLPVLLVLWIR 186
Cdd:cd17329 96 VLTGFGGGLFEPASEAMIADVTTPENRTRAfsllYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLFLLP 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 187 KSAPESQEwiEDKYKDKSTFLSVFRKPHLSISMIVFLVCFCLFGAnwpINGLLPSYLADNGVNTV-VISTLMTIAGLGTL 265
Cdd:cd17329 176 ETRPKRRA--AEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFQ---LESTLPVYVVEILGLGEsLLGLLLALNALLIV 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 266 TGTIFFGFVGDKIGVKKAFVVGLITSFIFLCPLFFISVKNSSLIGLCLF--GLMFTnlgiAGLVPKFIYDYFPTKLRGLG 343
Cdd:cd17329 251 LLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLtlGEMLV----FPAVQTLVAALAPPDKRGSY 326
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 90111718 344 TGLIYNLGATGGMAAPVLATY-ISGYYGLGVSLFIVTVAFSALLILL 389
Cdd:cd17329 327 MGFYALAWGLGRAIGPLVGGLlLDLLGPGLPWLILAALGLIAAALLL 373
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
14-313 |
2.65e-07 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 52.40 E-value: 2.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 14 RKALFSAWLGYVFDGFDFMMIFYILHIIKADLGITDIQA-TLIGTVAFiARPIGGGFFGAMADKYGRKPMMMWAIFIYSV 92
Cdd:PRK10091 2 KKVILSLALGTFGLGMAEFGIMGVLTELAHDVGISIPAAgHMISYYAL-GVVVGAPIIALFSSRYSLKHILLFLVALCVI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 93 GTGLSGIATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSF 172
Cdd:PRK10091 81 GNAMFTLSSSYLMLAIGRLVSGFPHGAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 173 F-IGLLPVLLVLWIRKSAPESQEWIEDKYKDKSTFLSVfRKPHLSISMIVF--LVCFCLFGAnwpingLLPSYLADNGVN 249
Cdd:PRK10091 161 LlIAVFNIAVLASIYFWVPDIRDEAKGGLREQFHFLRS-PAPWLIFAATMFgnAGVFAWFSY------IKPYMMFISGFS 233
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 90111718 250 TVVISTLMTIAGLGTLTGTIFFGFVGDKIG-VKKAFVVGLITSFIFLCPLFFISVKNSSLIGLCL 313
Cdd:PRK10091 234 ETSMTFIMMLVGLGMVLGNLLSGRLSGRYSpLRIAAVTDFIIVLALLMLFFFGGMKTASLIFAFI 298
|
|
| MFS_SV2C |
cd17440 |
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ... |
17-171 |
5.67e-07 |
|
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340998 [Multi-domain] Cd Length: 479 Bit Score: 51.45 E-value: 5.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 17 LFSAWLGYVFDGFDFMMIFYILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGL 96
Cdd:cd17440 1 FFVLGMALMADGVEVFVVGFVLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 90111718 97 SGIATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNS 171
Cdd:cd17440 81 SSFVQGYGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFS 155
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
71-390 |
7.42e-07 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 50.68 E-value: 7.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 71 GAMADKYG-RKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLGmSGEYACASTYAVESWPKNLQSKASAFLVSGFS 149
Cdd:cd17490 52 GILSDRIGkRKLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIA-AATWVSFTVLYASYFPPDEAAKAMGLINLVNN 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 150 VGNIIAAQIIPQFAEVYGWRNSFFIGLLPVLLVLWIRKSAPESQEWIEDKYKDKSTFLSVFRKPHLsisMIVFLVCFCLF 229
Cdd:cd17490 131 LGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPVLTELKELLSVLKDKKL---LFFSLLAILQQ 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 230 GANWPIN-GLLPSYLADNGVNTVVISTLMTIAGLGTLTGTIFFGFV-GDKIGVKKAFVVGLITSFIFLCPLFFIsvknSS 307
Cdd:cd17490 208 MITFSTTfGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLfYKKLGERNTIIIGFLLLGAYCFLIPFA----PN 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 308 LIGLCL--------FGLMFTNLgiAGLVPKFIydyfPTKLRGLGTGL---IYNLGATGGmaaPVLATYISGYYGLgVSLF 376
Cdd:cd17490 284 LTLLYLlqalngfgTGILFPLL--MSLSIEGV----PAEQRSTAMGFfqaIYALGMFLG---PVLVGIISEAFGL-QTGF 353
|
330
....*....|....
gi 90111718 377 IVTVAFSALLILLV 390
Cdd:cd17490 354 FVIGVIALLAAILS 367
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
221-392 |
9.32e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 50.29 E-value: 9.32e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 221 VFLVCFCLFGANWPINGLLPSYLADNGVNTVVISTLMTIAGLGTLTGTIFFGFVGDKIGVKKAFVVGLItsFIFLCPLFF 300
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLL--IFALATLLY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 301 ISVknSSLIGLCLFGLM------FTNLGIAGLVPkfiyDYFPTKLRGLGTGLiYNLGATGGMA-APVLATYISGYYGLGV 373
Cdd:cd17489 79 LLA--TSVALLLVLRLIhgigwgAFTTAAATLVA----DIIPPSRRGEGIGY-YGLATTLAMAlGPALGLFLYQHLGFAV 151
|
170
....*....|....*....
gi 90111718 374 sLFIVTVAFSALLILLVGF 392
Cdd:cd17489 152 -LFIVAAVLALLALLLVFL 169
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
67-195 |
1.02e-06 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 50.33 E-value: 1.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 67 GGFFGA-----MADKYGRKPMMMWAIFIYSVGTGLSGIATN-LYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKA 140
Cdd:cd17356 57 GSFFGAlissfLSDRIGRKKSIQIGCVIYIIGAIIQVAAIGkWYQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTL 136
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 90111718 141 SAFLVSGFSVGNIIAAQIIPQFAEVYG---WRNSFFIGLLPVLLVLWIRKSAPESQEW 195
Cdd:cd17356 137 VSLYQLAITIGILVAYCINYGTHKLDGsaqWRIPLGLQIVWGLLLLIGMFFLPESPRW 194
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
33-390 |
1.04e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 50.23 E-value: 1.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 33 MIFYILHIIKADLGITdiqATLIGTVAFIARPIGGG---FFGAMADKYG-RKPMMMWAIFIYSVGTGLSGIATNLYMLAV 108
Cdd:cd17370 17 MARSILPLFLVVLGAS---AAAVGLIEGLAEALGSLlrlFSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVLL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 109 CRFI--VGLGMSGeyACASTYAVESWPKNLQSKASAFL----VSGFSVGNIIAAQIIPQFAEVYgwRNSFFIGLLP---- 178
Cdd:cd17370 94 LRILerLGKGIRT--PPRDALLADATPPSGRGKAFGLHraldTLGAVLGPLLAALLLYLLGGNY--RTIFLLAAIPalla 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 179 VLLVLWIRKSAPESQewiedkykDKSTFLSVFRKPHLSISMIVFLVCFCLFGANWPINGLLPSYLADNGVNTVVISTLMT 258
Cdd:cd17370 170 LLILLFVVKEYPRPP--------KLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFAFLILRAQELGLSAALIPLLYA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 259 IAGLGTLTGTIFFGFVGDKIGVKKAFVVGLITSFIflCPLFFISVKNSSLIGLcLFGLMFTNLGI-AGLVPKFIYDYFPT 337
Cdd:cd17370 242 LFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLAL--AYLGFALGSSLWLLLL-GFILWGLYMGAqESIERAAVADLVPA 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 90111718 338 KLRGLGTGLIYNLGATGGMAAPVLATYISGYYGLGVsLFIVTVAFSALLILLV 390
Cdd:cd17370 319 ELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSA-AFLFSAVLALIALLLL 370
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
41-195 |
1.20e-06 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 50.09 E-value: 1.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 41 IKADLGITDIQ-ATLIGTVAFIARpIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLGMSG 119
Cdd:cd17437 23 IKEDLKISDVQeEVLIGSLNIISL-VGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLMVGRFVAGIGVGF 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 120 EYACASTYAVESWPKN----LQSKASAFLVSGFSVGnIIAAQIIPQFAEVYGWRNSFFIGLLPVLLVLWIRKSAPESQEW 195
Cdd:cd17437 102 ALMIAPVYTAEVAPASsrgfLTSFPEIFINIGILLG-YVSNYAFSGLPLHVGWRLMLGVGAVPSLFLAIGVLAMPESPRW 180
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
41-382 |
1.76e-06 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 49.55 E-value: 1.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 41 IKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLGMSGE 120
Cdd:cd17327 32 MKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGV 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 121 YACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAA------QIIPQFAEVYGWRNSFFI-GLLPVLLVLWI-------- 185
Cdd:cd17327 112 FPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGllaygvFKILGVGGLAGWRWLFIIeGLITIIIGLVIffwlpdnp 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 186 --------------RKSAPESQEWIEDKYKDKSTFLSVFRKPHLSISMIVFlvcFCLFGANWPINGLLPSYLADNGVNTV 251
Cdd:cd17327 192 skawflteeekelaVERLRANQTGKGDQKFKWKQIKEAFKDPRTWLLFLFF---FCSQITNNGISNFLPLILKSLGFYSL 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 252 VISTLMTIAGLGTLTGTIFFGFVGDKIGVKKAFVVGL-ITSFIFLCPLFFISVKNSSLIGLCLFGLMF--TNLGIAGLVP 328
Cdd:cd17327 269 QTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFAcVLALVGSIILLAAPNPPGAYFAAYILGGGSyaGFPILLSWIS 348
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 329 KFIYDYFPtklRGLGTGLIYNLGATGGMAAPVLA------TYISGYYGLGVSLFIVTVAF 382
Cdd:cd17327 349 SNCAGYTK---RATVLAIMLIFYNVGNIVAPQIFragdapRYIPGNIALLVCACVSIVLS 405
|
|
| MFS_SV2A |
cd17439 |
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ... |
18-175 |
1.85e-06 |
|
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340997 [Multi-domain] Cd Length: 478 Bit Score: 49.64 E-value: 1.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 18 FSAWLGYVFDGFDFMMIFYILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLS 97
Cdd:cd17439 2 FVLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFS 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 90111718 98 GIATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWrnSFFIG 175
Cdd:cd17439 82 SFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGW--SFQMG 157
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
239-395 |
2.57e-06 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 49.28 E-value: 2.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 239 LPSYLADNGVNTVVISTLMTIAGLGTLTGTIFFGFVGDKIGVKKAFVVGLITSFIFLCplffISVKNSSLIGLCLFGLmF 318
Cdd:TIGR00895 40 APAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTL----LCALATNVTQLLILRF-L 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 319 TNLGIAGLVPK---FIYDYFPTKLRGLGTGLIYNLGATGGMAAPVLATYISGYYGLGvSLFIVTVAFSALLILLVGFDIP 395
Cdd:TIGR00895 115 AGLGLGGLMPNlnaLVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWR-SLFYVGGIAPLLLLLLLMRFLP 193
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
14-156 |
5.70e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 47.80 E-value: 5.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 14 RKALFSAWLGYVFDGFDFMMIFYILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVG 93
Cdd:pfam07690 199 RDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILA 278
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 90111718 94 TG---LSGIATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAA 156
Cdd:pfam07690 279 ALgllLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
22-196 |
5.81e-06 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 48.38 E-value: 5.81e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 22 LGYVFDGFDFMMIFYILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIAT 101
Cdd:cd17438 6 LALMADGVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQ 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 102 NLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAA----QIIPQFA---------EVYGW 168
Cdd:cd17438 86 GYGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASamawSIIPHYGwgfsmgtnyHFHSW 165
|
170 180
....*....|....*....|....*...
gi 90111718 169 RNSFFIGLLPVLLVLWIRKSAPESQEWI 196
Cdd:cd17438 166 RVFVIICALPCIASIIALKFMPESPRFL 193
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
37-388 |
7.09e-06 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 47.68 E-value: 7.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 37 ILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLG 116
Cdd:cd06180 21 LLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 117 MSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQF-AEVYGWRNSFFI-----GLLPVLLVLWIRKSAP 190
Cdd:cd06180 101 SAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGlGGGLSWRAGWLAlallsAVLLLLSFLLLRRGPS 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 191 ESQEwiedkykdkstFLSVFRKPHLSISMIVFLVCFCLFGANWPING-LLPSYLADNGVNTVVISTLMTIAGLGTLTGTI 269
Cdd:cd06180 181 APTE-----------ASAAESAPGLNRPLWRLALAYGLFGFGYIITAtFLPLIARETGAGSLLAGLLWSLFGLAAVPSCF 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 270 FFGFVGDKIGVKKAFVVGLITSFI-FLCPLFFISVknsSLIGLCLFGLMFTNLGIAGLVPKFIYDYFPTKLRGLgTGLIY 348
Cdd:cd06180 250 LWGALSDRWGTRRALAANLLVQAVgVLLPLLSPGP---AGLVLSAVLFGGTFMAITALVMALARELAPPAAPRA-LALMT 325
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 90111718 349 NLGATGGMAAPVLATYISGYYGlgvSLFIVTVAFSALLIL 388
Cdd:cd06180 326 ASFGVGQILGPLLAGWLADATG---GFAPALILAAAALVV 362
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
64-361 |
8.13e-06 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 47.29 E-value: 8.13e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 64 PIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAF 143
Cdd:cd17374 49 LVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALAITL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 144 LVSGFSVGNIIAAQIIPQFAEvygWRNSFFIGLLPVLLvlwirksapesqewiedkykdkstFLSVFRKphlsISMIVFL 223
Cdd:cd17374 129 TSCFFSIGQMLLAGLAYAIRD---WRLLQLVVSVPFFL------------------------FFLYSWW----LPKRTLI 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 224 VCFCLFGANWPINGLLPSyLADNGVNtvvISTLMTIAGLGTLTGTIFFGFVGDKIGVKKAFVVGLITSFIFLCPLFFISV 303
Cdd:cd17374 178 LSFVWFANSFSYYGLSLD-LQHLGLN---VFLLQFLFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLCILANIFVPQ 253
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 90111718 304 KNSSL------IGLCLFGLMFTNLGIaglvpkFIYDYFPTKLRGLGTGLIYNLGATGGMAAPVL 361
Cdd:cd17374 254 EMQTLrtvlavLGKGSSAAAFTISYV------YTAELFPTVLRQTGMGLNSMFARIGGILAPLI 311
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
5-188 |
8.16e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 47.61 E-value: 8.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 5 WYKQVNPPQRKALFSAWLGYVFDGfdfMMIFYILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMM 84
Cdd:cd06173 202 RYLRRSPLLRLLLLALALFALLGG---ALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLL 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 85 WAIFIYSVGTGLSGIATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAE 164
Cdd:cd06173 279 IGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLAD 358
|
170 180
....*....|....*....|....*
gi 90111718 165 VYGWRNSFFI-GLLPVLLVLWIRKS 188
Cdd:cd06173 359 ALGLSAVFLLaGALLLLAALLLLLL 383
|
|
| MFS_SLC22A7_OAT2 |
cd17447 |
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ... |
57-158 |
1.46e-05 |
|
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341005 [Multi-domain] Cd Length: 341 Bit Score: 46.65 E-value: 1.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 57 TVAFIARPIGGGFFGAMADKYGRKPMMMWAiFIYSVGTGL-SGIATNLYMLAVCRFIVGLGMSGEYACASTYAVEsWPKN 135
Cdd:cd17447 42 TFFFAGVTMGAVAFGYLSDRFGRKRMLLVA-YVLSLVFGLaSAFSVSYVMFAITRTLTGFALTGFSIISMVLCVE-WVDI 119
|
90 100
....*....|....*....|....
gi 90111718 136 LQSKASAFLVS-GFSVGNIIAAQI 158
Cdd:cd17447 120 EHRTVAGVLISlFWTVGNMLLALV 143
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
27-115 |
1.46e-05 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 46.84 E-value: 1.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 27 DGFDFMMIFYILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYML 106
Cdd:cd17390 8 DLFGVSMILPLLSTHIRSLGASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALL 87
|
....*....
gi 90111718 107 AVCRFIVGL 115
Cdd:cd17390 88 FLSRIPLGI 96
|
|
| MFS_SVOP |
cd17441 |
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ... |
32-189 |
1.54e-05 |
|
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340999 [Multi-domain] Cd Length: 372 Bit Score: 46.73 E-value: 1.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 32 MMIFYILH-IIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMM----MWAIFiYSVgtgLSGIATNLYML 106
Cdd:cd17441 15 MMILSILApQLHCEWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLkisvLWTLY-YGI---LSAFAPIYSWI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 107 AVCRFIVGLGMSGEYACASTYAvESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSFFIGLLPVL----LV 182
Cdd:cd17441 91 LVLRGLVGFGIGGVPQSVTLYA-EFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPTLGWRWLLILSALPLLifavLC 169
|
....*..
gi 90111718 183 LWIRKSA 189
Cdd:cd17441 170 FWLPESA 176
|
|
| MFS_OCT_plant |
cd17378 |
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ... |
60-391 |
2.43e-05 |
|
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340936 [Multi-domain] Cd Length: 342 Bit Score: 45.81 E-value: 2.43e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 60 FIARPIGGGFFGAMAD-KYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQS 138
Cdd:cd17378 43 FVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRSGIGTCALVLATEPVGPKWRG 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 139 KASAFLVSGFSVGNIIaaqiIPQFAEVYG--WRNSFFIGLLPVLLVlwirksapesqewiedkykdkSTFLSVFRKPHLS 216
Cdd:cd17378 123 QVGMSTFFFFVLGFMS----LPGIAYLNGssWRVLYFWTSIPALIY---------------------CILVYLFARRLLA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 217 ISMIVFLVCFCLFGanwpinglLPSYLADNGVNTVVISTLMTIAGLGTLTGTiffGFVGDKIGVKKAFVVGLITSFIFLC 296
Cdd:cd17378 178 VMVIGFGIGMVYYG--------IPLAVGNLKFNIYLSVALNALSELPAFVIT---AFLLDRFGRRPSLLGFTLLSGASCL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 297 PLFFISVKNSSLIGLCLFGLMFTNLGIA-GLVPKFIYDYFPTKLRGLGTGLIYNLGATGGMAAPVLAtyISGYYGLGVSL 375
Cdd:cd17378 247 LCFVLSIGGTTSLQIALELVGFFGAAGAfNLLYIYTVELFPTCVRNAALGMLRQALVVGGIFAPFIV--SLGRKNAALSF 324
|
330
....*....|....*.
gi 90111718 376 FIVTVAFSALLILLVG 391
Cdd:cd17378 325 GVFGVAILLLGLFALG 340
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
32-328 |
2.57e-05 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 46.06 E-value: 2.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 32 MMIFYILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKY-----GRKPMMMWAIFIYSVGTGL--SGIATNLY 104
Cdd:cd17332 17 IVSTYLLFFYTDVLGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTrsrwgRFRPWLLWGAIPLALLFVLlfTTPDGSGT 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 105 MLAVCRFIVGLGMSGEYACASTyAVESWPKNL------QSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSFF----- 173
Cdd:cd17332 97 GKLIYALITYILLDLLYTLVNI-PYTALIPELtddpeeRTSLTSWRMFFATIGGLLVTVLPPPLVAYFGGGNASRgyflt 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 174 ------IGLLPVLLVLWIRKSAPESQEWIEDKYKDKSTFLSVFRKPHLSISMIVFLVCFCLFGAnwpINGLLPSYLADNG 247
Cdd:cd17332 176 aliigiIGIILLLICFFGTRERVVPPEEEKSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNI---VNTVLVYYFKYVL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 248 VNTVVISTLMTIAGLGTLTGTIFFGFVGDKIGVKKAFVVGLItSFIFLCPLFFISVKNSSLIGLCLFGLMFTNLGIAGLV 327
Cdd:cd17332 253 GGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLL-LAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLL 331
|
.
gi 90111718 328 P 328
Cdd:cd17332 332 P 332
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
15-202 |
3.52e-05 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 45.87 E-value: 3.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 15 KALFSAWLGYVFDGFDFM-------MIFYILHIIKADLgITDIQATLIGtVAFIARPIGGGFFGAMADKYGRK---PMMM 84
Cdd:TIGR00887 16 RAIVIAGVGFFTDSYDLFcislvtkMLGYVYYHGKGPL-PSSVSAAVNG-SASIGTLAGQLFFGWLADKLGRKrvyGMEL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 85 WAIFIYSVGTGLSG--IATNLYMLAVC-RFIVGLGMSGEYACAST----YAVESWPKNLQSKASAFLVSGFSVGNIIAAQ 157
Cdd:TIGR00887 94 IIMIIATVASGLSPgsSPKSVMATLCFwRFWLGVGIGGDYPLSAIitseFATKKWRGAMMAAVFAMQGFGILAGAIVALI 173
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 90111718 158 IIPQF-------------------AEVYGWRNSFFIGLLPVLLVLWIRKSAPESQEWIEDKYKD 202
Cdd:TIGR00887 174 VLAGFkhsleaaadeasctgscvpAVDYMWRILIGFGAVPALLALYFRLTIPETPRYTADVAKD 237
|
|
| PRK15075 |
PRK15075 |
tricarballylate/proton symporter TcuC; |
29-235 |
3.69e-05 |
|
tricarballylate/proton symporter TcuC;
Pssm-ID: 237902 [Multi-domain] Cd Length: 434 Bit Score: 45.70 E-value: 3.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 29 FDFMMI-FYILHIIKADLGITDIQATLIGTVA-----FIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLS----- 97
Cdd:PRK15075 29 FDFFLFgFYATAIAKTFFPAGNEFASLMLTFAvfgagFLMRPLGAIVLGAYIDRVGRRKGLIVTLSIMASGTLLIafvpg 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 98 ----GIATNLYMLaVCRFIVGLGMSGEYACASTYAVE-----------SWpknlQSkAS---AFLVSGFsVGNIIAAQII 159
Cdd:PRK15075 109 yatiGLAAPLLVL-LGRLLQGFSAGVELGGVSVYLAEiatpgrkgfytSW----QS-ASqqvAVVFAAL-LGYLLNQWLS 181
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 90111718 160 PQFAEVYGWRNSFFIGLLPVLLVLWIRKSAPESQEwiedkykdkstFLSvfRKPHLSISMIvflvcFCLFGANWPI 235
Cdd:PRK15075 182 PAQMAEWGWRIPFLIGCLIVPFIFLIRRSLEETEE-----------FLA--RKHRPSMREI-----FRSLAANWRI 239
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
44-328 |
4.37e-05 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 45.18 E-value: 4.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 44 DLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGL---SGIATNLY-MLAVCRFIVGLGmsg 119
Cdd:cd17337 26 DLGFSEAQAALLFTVYGLTVAIASWLSGVLAELFGPRRVMLIGLIIWLVFEVLflaFGLPSHNYpLMLLTYGLRGFG--- 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 120 eYACAStYAVESW-----PKNLQSKASAFLVSGFS-----VGNIIAAQIIPQFAEVYGWRNSFFIGLLPVLLVLWIRKSA 189
Cdd:cd17337 103 -YPLFA-YSFLVWityrtPAERLGSAVGWFWFAFTgglpvLGSYLASFTIPVIGEIGTLWLSLVFVALGGLIALFLVRDR 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 190 PESQEWIEDKYKDKSTFLS----VFRKPHLSISMIVFLVC-FCLFGanWPIngLLPSYLADN-GVNTVVISTLMTIAGLG 263
Cdd:cd17337 181 TGEQPLANPSEEPLKELLSgitiLFRNPKIAIGGIVRIINtLSQFG--FPV--FMPLYFTDTgGFSTSQWLQIWGIIFLV 256
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 90111718 264 TLTGTIFFGFVGDKIGVKK------AFVVGLITSFIFLCPLFFISVKNSSLIGLCLFGlmftnLGIAGLVP 328
Cdd:cd17337 257 NIFFNLIFGILGDKIGWRRtvrwfgGVGCAISTLLFYYVPQLFGHNYWAALIAAILFG-----IGLAGFVP 322
|
|
| MFS_STP |
cd17361 |
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ... |
53-183 |
6.73e-05 |
|
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340919 [Multi-domain] Cd Length: 390 Bit Score: 44.55 E-value: 6.73e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 53 TLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLGMSGEYACASTYAVESW 132
Cdd:cd17361 54 QLFTSSLYLAGLVASLLASYVTRKWGRKPSMLIGGVLFLVGAALNAAAQNIAMLIVGRILLGFGVGFGNQAVPLYLSEMA 133
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 90111718 133 PKNLQSKasafLVSGFSVGN---IIAAQIIPQFAEV---YGWRNSFFIGLLPVLLVL 183
Cdd:cd17361 134 PAKLRGA----LNIGFQLAItigILIANLINYGTSKikpNGWRLSLGLAAVPALILL 186
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
71-190 |
7.96e-05 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 44.53 E-value: 7.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 71 GAMADKYGRKPMMMWAIFIYSVGTGLSGIATNL--YMLAVCRFIVGLGmSGEYACASTYAVESW-PKNLQSKASAFLVSG 147
Cdd:cd17318 77 GYLAEKYGAKRVLGYSILITALLTLLTPLAARGgyGALIVLRILQGLA-QGVTFPAMHALWAKWaPPLERSRLTSIAYSG 155
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 90111718 148 FSVGNIIAAQIIPQFAEVYGWRNSFFI-GLLPVL-LVLWIRKSAP 190
Cdd:cd17318 156 SQFGTVIAMPLSGFLCESLGWPSIFYIfGGLGLLwCLLWFFLVLP 200
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
40-185 |
9.54e-05 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 44.14 E-value: 9.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 40 IIKADLGITD--IQATLIGTVAFIArpIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLgm 117
Cdd:PRK11102 16 VIAADFGVSAgsVQMTLSAYILGFA--IGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGL-- 91
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 90111718 118 SGEYACASTYAV--ESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSFFI----GLLPVLLVLWI 185
Cdd:PRK11102 92 AAAAASVVINALmrDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVlalaAILAAALVFFF 165
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
27-168 |
9.75e-05 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 44.40 E-value: 9.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 27 DGFDFMMIFYILHIIKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYML 106
Cdd:cd17363 11 DGVEVFVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQGYGFF 90
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 90111718 107 AVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAA----QIIPQfaevYGW 168
Cdd:cd17363 91 LFCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSWLCMFWMIGGLYASamawAIIPH----YGW 152
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
14-160 |
1.77e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 43.34 E-value: 1.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 14 RKALFSAWLGYVFDGFDFMMIFYILHII-----KADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIF 88
Cdd:cd17504 176 RRNVLLANITALLAGFGMFMVFQLLPQLlqlptPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLV 255
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 90111718 89 IYSVG-TGLSGIATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIP 160
Cdd:cd17504 256 ISAVGlLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAG 328
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
50-396 |
2.51e-04 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 43.07 E-value: 2.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 50 IQATLIGTVAFIAR-------PIGGGFFGAMADKYGR-KPMMMWAIFIYSVGTGL------SGIATNLYMLAVCRFIVGL 115
Cdd:pfam13347 30 LSAAAVGLVLLVARlvdaftdPIVGHIIDRTRTRWGRrRPWLLLSAIILAVSFILlftppeLGRAPLFIWLLATYILLRI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 116 GMSGEYACASTYAVESWPKN-----LQSKASAFLVSGFSVGNIIAAQIIPQFA----EVYGWRNSFFIGLLPVLLVLWIR 186
Cdd:pfam13347 110 AYTFFEIPYWSLGPELTRDYdertsLTSYRSFFSVGGGLLAAALAFPLVLILGgtglERKGYRIFALIGAVLMLLGVIIT 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 187 KSAPESQEWIEDKYKDKST--------FLSVFRKPHLSISMIVFLVCFCLFGANwpiNGLLPSYLADNGVNTVVISTLMT 258
Cdd:pfam13347 190 AAGTKERVSMRSKEDTGQKeagslldmLKEVFRNRAFLILLASFLLAALAMGVL---NGLLLYYFRYVLGNGFAASAFPL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 259 IAGLGTLTGTIFFGFVGDKIGVKKAFVVGLITSFIFLCPLFFISVKNSSLIGLCLFGLMFTNLGIAGLVPKFI-----YD 333
Cdd:pfam13347 267 VFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALALLLGPNNTLLFLVLYIIIGFGYGSSFFLPWSMLadvvdYG 346
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 334 YFPTKLRGLGT-----GLIYNLGATGGMAAPVLATYISGY------------YGLGVSLFIVTVAFSAL-LILLVGFDIP 395
Cdd:pfam13347 347 ELRTGKRREGTffamwSFISKLATGVGLGVSGLLLSAFGYnagdsvqspqavTAIRLLYAVLPAVLFLVaLLLLYFYPLD 426
|
.
gi 90111718 396 G 396
Cdd:pfam13347 427 R 427
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
29-183 |
3.80e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 42.15 E-value: 3.80e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 29 FDFMMIFYILHIikADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAV 108
Cdd:cd17370 215 GNFSFAFLILRA--QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLL 292
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 90111718 109 CRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSFFIGLLPVLLVL 183
Cdd:cd17370 293 GFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIAL 367
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
71-195 |
4.66e-04 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 41.95 E-value: 4.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 71 GAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPknlqSKASAFLVS---G 147
Cdd:cd17362 60 GALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSP----SHIRGLLVSlkeL 135
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 90111718 148 FSVGNIIAAQIIP--QFAEVYGWRNSFFIGLLPVLLVLWIRKSAPESQEW 195
Cdd:cd17362 136 FIVLGILLGYVSGyaFADVVGGWRYMYGLAAPPALLLGIGMWFLPPSPRW 185
|
|
| MFS_YdiM_like |
cd17396 |
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ... |
61-392 |
5.44e-04 |
|
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 41.95 E-value: 5.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 61 IARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKnLQSKA 140
Cdd:cd17396 46 IGRLLTILFAGVLSDKFGRKPSVLLGMVLYALFFVGILFSPNLIIAYVFALLAGAANSFLDTGTYPALMEAFPK-ASGSA 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 141 SAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSFFIGLLPVLLV----LWIRKSAPESQEWIEDKYKDKSTFLSvfrKPHLS 216
Cdd:cd17396 125 NILVKAFVSFGQFLLPFIIAFLAANNLWYGWSFIVPAAVLVLnallLLKLSFPPQTVTAANTKQKEIPVKRE---KPKFL 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 217 ISMIVF-LVCFCLFGANWPINGLLPSYLADNGVNTVVIST-LMTIAGLGTLTGT-IFFGFVGDKIGVKKAFVVGLITSFI 293
Cdd:cd17396 202 IEGIALiLIGFTSTATFYLFSQWMPKYGSAVAGMGEAESLkLISYYSMGSLVCVfITAVLLKRYVRPIWILVLYPIISLL 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 294 FLCPLFFISVKNSSLIGLCLFGLmFTNLGIAGLVPKFIYDYFPTKlRGLGTGLIYNLGATGGMAAPVLATYISGYYGLG- 372
Cdd:cd17396 282 ALFVLYLVPSPDVCILGAFVIGF-FAAGGVLQLGLTLMAEFFPKG-KGKVTGIYMIASSLANFVIPLITGIIASAIGIAy 359
|
330 340
....*....|....*....|
gi 90111718 373 VSLFIVTVAFSALLILLVGF 392
Cdd:cd17396 360 IFLFDFGIALLGLLLAIFVF 379
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
79-324 |
5.67e-04 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 41.80 E-value: 5.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 79 RKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIA--- 155
Cdd:PRK03545 73 RRKLLIGLFVLFIASHVLSALAWNFTVLLISRIGIAFAHAIFWSITASLAIRVAPAGKKAQALSLLATGTALAMVLGlpl 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 156 AQIIPQFaevYGWRNSFF-IGLLPVLLVLWIRKSAP--ESQewiedkykDKSTFLSV---FRKPHL-SISMIVFLVCFCL 228
Cdd:PRK03545 153 GRVIGQY---LGWRTTFLaIGGGALITLLLLIKLLPllPSE--------HSGSLKSLpllFRRPALvSLYLLTVVVVTAH 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 229 FGANWPINgllPSYLADNGVNTVVISTLMTIAGLGTLTGTIFFGFVGDKIgvKKAFVVGLItSFIFLC--PLFFISVKNS 306
Cdd:PRK03545 222 FTAYSYIE---PFVQQVAGLSENFATLLLLLFGGAGIIGSVLFSRLGNRH--PSGFLLIAI-ALLLVCllLLLPAANSEW 295
|
250
....*....|....*....
gi 90111718 307 SLIGLCLF-GLMFTNLGIA 324
Cdd:PRK03545 296 HLSVLSIFwGIAIMCIGLA 314
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
65-156 |
8.16e-04 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 41.25 E-value: 8.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 65 IGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFL 144
Cdd:cd17446 48 VGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGIVLNSVSLNVEWMPTRVRAVVGTLL 127
|
90
....*....|..
gi 90111718 145 VSGFSVGNIIAA 156
Cdd:cd17446 128 GYCYTLGQLILA 139
|
|
| nepI |
PRK10213 |
purine ribonucleoside efflux pump NepI; |
44-226 |
9.63e-04 |
|
purine ribonucleoside efflux pump NepI;
Pssm-ID: 182309 [Multi-domain] Cd Length: 394 Bit Score: 41.06 E-value: 9.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 44 DLGITD-IQATLIGTVAFIARpIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLGMSGEYA 122
Cdd:PRK10213 49 DLGISEgVAGQSVTVTAFVAM-FASLFITQTIQATDRRYVVILFAVLLTLSCLLVSFANSFSLLLIGRACLGLALGGFWA 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 123 CASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSF-FIGLLPVLLVLWIRKSAPESQewiEDKYK 201
Cdd:PRK10213 128 MSASLTMRLVPPRTVPKALSVIFGAVSIALVIAAPLGSFLGELIGWRNVFnAAAVMGVLCIFWIIKSLPSLP---GEPSH 204
|
170 180
....*....|....*....|....*
gi 90111718 202 DKSTFLSVFRKPHLSISMIVFLVCF 226
Cdd:PRK10213 205 QKQNTFRLLQRPGVMAGMIAIFMSF 229
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
18-176 |
9.97e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 41.07 E-value: 9.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 18 FSAWLGYVFDGFDFMMIFYILHIIKADLGiTDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLS 97
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADLG-PSSNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 98 GIATNLYMLAVCRFIVGLGMSGE---YACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEvyGWRNSFFI 174
Cdd:cd06179 80 GTAKSVNMLIGGQALIGIGAGTQglgAAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAA--GWRWIFYI 157
|
..
gi 90111718 175 GL 176
Cdd:cd06179 158 NA 159
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
22-151 |
1.21e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 40.63 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 22 LGYVFDGFDFMMIFYILHI-----IKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGL 96
Cdd:cd17473 200 LPIYFLAFLAMLLFYVIPIqlpflLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLL 279
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 90111718 97 SGIATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVG 151
Cdd:cd17473 280 LALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLG 334
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
65-362 |
4.53e-03 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 38.96 E-value: 4.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 65 IGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATN--LYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASA 142
Cdd:TIGR00894 91 IIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGggIALVVFCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLG 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 143 FLVSGFSVGNIIAAQIIPQFAEVY-GWRNSFFIGLL--PVLLVLWIRKSA--PESQEWI---EDKYKDKSTFLSVFRKPH 214
Cdd:TIGR00894 171 MSTSGFQLGTFIFLPISGWLCESWgGWPMIFYVFGIvgCAWSLLWFVFPAddPSIHPCIskfEKKYINSSLQGQKGSTRQ 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 215 LSI------SMIVFLVCFCLFGANWPINgLLPSYL---------ADNGVNTVVISTLMTIAGL-GTLTGTIFFGFVGDKI 278
Cdd:TIGR00894 251 SLPikaipkSLPVWAIWFAIFGHFWLYT-ILPTYLptfiswvlrVSGKENGLLSSLPYLFAWLcSIFAGYLADFLKSSKT 329
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 279 GVKKAfVVGLITSFIFLCPLFFI-------SVKNSSLIGLCLFGLmfTNLGIAGLVPKFIYDYFPTKLrGLGTGLIYNLG 351
Cdd:TIGR00894 330 LSLTA-ARKIFNGIGGLGPGIFAyalpylsAAFYLTIIILTLANA--VSSGPLAGVLINSLDLAPRFL-GFIKGITGLPG 405
|
330
....*....|.
gi 90111718 352 ATGGMAAPVLA 362
Cdd:TIGR00894 406 FIGGLIASTLA 416
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
41-183 |
5.28e-03 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 38.90 E-value: 5.28e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 41 IKADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLGMSGE 120
Cdd:TIGR00711 28 IAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGGGPL 107
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 90111718 121 YACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSFFIGLLPVLLVL 183
Cdd:TIGR00711 108 IPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVV 170
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
21-174 |
5.46e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 38.75 E-value: 5.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 21 WLGYVFDGFDFMMIFYILHII-KADLGITDIQATLIGTVAFIARPIGGGFFGAMADKYGRKPMMMWAIFIYSVGT-GLSG 98
Cdd:cd17353 219 WLMFFLNATAGLMLIGQAKPIgQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMfLLPF 298
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 90111718 99 IATNLYMLAVCRFIVGLGMSGEYACASTYAVESWPKNLQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSFFI 174
Cdd:cd17353 299 IGSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFII 374
|
|
| MFS_SV2B |
cd17438 |
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ... |
238-375 |
5.63e-03 |
|
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340996 [Multi-domain] Cd Length: 477 Bit Score: 38.75 E-value: 5.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 238 LLPSYLADNGVNTVVISTLMTIAGLGTLTGTIFFGFVGDKIGVKKAFVVGLITSFIFLCPLFFISVknsslIGLCLFGLM 317
Cdd:cd17438 21 VLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQG-----YGAFLFCRL 95
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 90111718 318 FTNLGIAGLVPkFIYDYFPTKL----RGLGTGLIYNLGATGGMAAPVLATYISGYYGLGVSL 375
Cdd:cd17438 96 ISGFGIGGSLP-IVFAYFSEFLarekRGEHLSWLCMFWMIGGLYASAMAWSIIPHYGWGFSM 156
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
238-375 |
5.86e-03 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 38.80 E-value: 5.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 238 LLPSYLADNGVNTVVISTLMTIAGLGTLTGTIFFGFVGDKIGVKKAFVVGLITSFIFlcpLFFISVKNSslIGLCLFGLM 317
Cdd:TIGR01299 189 VLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSVNGFF---AFFSSFVQG--YGFFLFCRL 263
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 90111718 318 FTNLGIAGLVPkFIYDYFPTKL----RGLGTGLIYNLGATGGMAAPVLATYISGYYGLGVSL 375
Cdd:TIGR01299 264 LSGFGIGGAIP-IVFSYFAEFLaqekRGEHLSWLCMFWMIGGIYAAAMAWAIIPHYGWSFQM 324
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
37-116 |
6.42e-03 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 38.40 E-value: 6.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 37 ILHIIKADLGITDIQATLIGTV------AFIArpigggFFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCR 110
Cdd:cd17476 20 ILPIIGDSFGTSPNQLSWLAASysltvgTFIL------IFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICR 93
|
....*.
gi 90111718 111 FIVGLG 116
Cdd:cd17476 94 ALQGLG 99
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
53-293 |
8.20e-03 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 38.00 E-value: 8.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 53 TLIGTVAFIARPIgggfFGAMADKYGRKPMMMWAIFIYSVGTGLSGIATNLYMLAVCRFIVGLgMSGEYACASTYAVESW 132
Cdd:cd17388 45 ALYALMQFIFAPI----LGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGI-TGATGAVAAAYIADVT 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 133 PKNLQSKASAFLVSGFSVGnIIAAQIIPQFAEVYGWRNSFFI-----GLLPVLLVLWIRKSAPESQEWIEDKYKDK--ST 205
Cdd:cd17388 120 PPEQRARNFGLLGAAFGLG-FIAGPALGGLLGEISPRAPFLVaaglnGLNFLLGLFVLPESLPPERRRAFRWRRANpfGS 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 206 FLSVFRKPHLSISMIVFLVCFC---LFGANWPIngllpsYLADN-GVNTVVIStlMTIAGLGTLTG---TIFFGFVGDKI 278
Cdd:cd17388 199 LRWLTGFPGLLGLLAVFFLIQLigqVPATTWVL------FTEDRfDWSPTMVG--LSLAVFGLLHAlfqAFVTGPIAKRL 270
|
250
....*....|....*
gi 90111718 279 GVKKAFVVGLITSFI 293
Cdd:cd17388 271 GEKRAILLGLAADAL 285
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
44-390 |
8.32e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 37.91 E-value: 8.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 44 DLGITDIQATLIGTVAFIARPIGGGFFGAMADK-YGRKPMMMWAIFIYSVGTGLSGIATNLYM-LAVCRFIVGLG---MS 118
Cdd:cd17471 26 ELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALGYLLFAFLRNYWVlLLVGVVLLSLGaaaFP 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 119 GEYACASTYAVESWPKNlQSKASAFLVSGFSVGNIIAAQIIPQFAEVYGWRNSF----FIGLLPVLLVLWIRKSAPESQE 194
Cdd:cd17471 106 QLFALAREYADRSSGRD-ATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFllaaLLYLVVALLVLFLLPSVKPPAQ 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 195 wiedKYKDKSTFLSVFRKPHLsisMIVFLVCFCLFGANWPINGLLPSYLADN-GVNTVVISTLMTIAGLGTLTGTIFFGF 273
Cdd:cd17471 185 ----KATPASSLVKAPVNRRL---LLLFAAFTLLFAANSMYIIAMPLYVTNElGGSESWVGLLFGLAAALEIPIMLLAGL 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 274 VGDKIGVKKAFVVGLITSFIFLCPLFFISVKnSSLIGLCLFGLMFTNLgIAGLVPKFIYDYFPTKLrGLGTGLIYNLGAT 353
Cdd:cd17471 258 LAKRFGKRRLLLAGFLAGVLFYLGLALATSL-WQLIALQLLNAIFIGI-TAGLGISYFQDLMPGQP-GLATTLYSNASRI 334
|
330 340 350
....*....|....*....|....*....|....*..
gi 90111718 354 GGMAAPVLATYISGYYGLGvSLFIVTVAFSALLILLV 390
Cdd:cd17471 335 GSLLGGLLAGVIAQYFGYR-AVFLVCAVLALLALVLL 370
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
219-395 |
8.37e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 37.91 E-value: 8.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 219 MIVFLVCFCLFGANWPINGLLPSYLADNGVNTVVISTLMTIAGLGTLTGTIFFGFVGDKIGVKKAFVVGLITsFIFLCPL 298
Cdd:cd17324 2 LALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLL-FILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 90111718 299 FFISVKNSSLIgLCLFGLMFTNLGIAGLVPKFIYDYFPTKLRGLGTGLIYNLGATGGMAAPVLATYISGYYGLGVSlFIV 378
Cdd:cd17324 81 AALAPSFALLL-LARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAA-FLA 158
|
170
....*....|....*..
gi 90111718 379 TVAFSALLILLVGFDIP 395
Cdd:cd17324 159 IAVLALLAALLLWRLLP 175
|
|
| |
