|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
23-369 |
1.21e-125 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 366.70 E-value: 1.21e-125
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 23 LTLGMGLGRFLYTPMLPVMMAEGSFSFSQLSWIASGNYAGYLAGSLLFSFGAFHQPSRLRPFLLASALASGLLILAMAWL 102
Cdd:pfam06779 1 LTVGMGIGRFSYTPILPVMIAEGQFSLSQAGLLAAANYAGYLAGALLASFAWRHGASRLRPALLAGLLATVLLLLAMAAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 103 PPFILVLLIRVLAGVASAGMLIFGSTLIMQH---TRHPFVLAALFSGVGIGIALGNEYVLAGLHFDLSSQTLWQGAGALS 179
Cdd:pfam06779 81 SSFWAVLLIRFLAGVASAAVMIFGSSLILGHataARRAFVGALLFAGVGIGIALSGLLVPLGLQLGLGGSSLWYGAGVLS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 180 GMMLIALTLLMP--SKKHAITPMPLAKTEQQIMSWWLLAILYGLAGFGYIIVATYLPLMAKD-AGSPLLTAHLWTLVGLS 256
Cdd:pfam06779 161 AVLTLAVFPLLPrrAPRHASAPAPAAKPLQRSLPLWILTLAYGLAGFGYIITATFLPAMARDgFGGPAAAALFWSLFGLA 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 257 IVPGCFGWLWAAKRWGALPCLTANLLVQAICVLLTLASDSPLLLIISSLGFGGTFMGTTSLVMTIARQLSVPGNLNLLGF 336
Cdd:pfam06779 241 AALGVLVWLRAAKRWGTRPALTAALLIQALGVLLSLLSPSPAGLAVSSLLFGGTFMAITSLVMQLARELAPPAPRRLLGL 320
|
330 340 350
....*....|....*....|....*....|...
gi 16132153 337 VTLIYGIGQILGPALTSMLSNGTSALASATLCG 369
Cdd:pfam06779 321 MTASFGIGQILGPLLASLLTAATGGLTPALLLA 353
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
17-384 |
7.14e-106 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 316.55 E-value: 7.14e-106
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 17 LFGMLVLTLGMGLGRFLYTPMLPVMMAEGSFSFSQLSWIASGNYAGYLAGSLLFSFGAFHQpsRLRPFLLASALASGLLI 96
Cdd:cd06180 1 LAGALALAVAMGIGRFAYTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRG--RARRLIRGGLLLTVLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 97 LAMAWLPPFILVLLIRVLAGVASAGMLIFGSTLIMQHT---RHPFVLAALFSGVGIGIALGNEYVLAGLHFDLSSQTLWQ 173
Cdd:cd06180 79 AAMALTSGFAALLALRFLAGAASAFVFVFGSNLVLHHAtaaGRGHLIGLLFAGVGLGIALSGLLVPAGLGGGLSWRAGWL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 174 GAGALSGMMLIALTLLMPSKKHAITPMPLA-KTEQQIMSWWLLAILYGLAGFGYIIVATYLPLMAKD-AGSPLLTAHLWT 251
Cdd:cd06180 159 ALALLSAVLLLLSFLLLRRGPSAPTEASAAeSAPGLNRPLWRLALAYGLFGFGYIITATFLPLIAREtGAGSLLAGLLWS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 252 LVGLSIVPGCFGWLWAAKRWGALPCLTANLLVQAICVLLTLASDSPLLLIISSLGFGGTFMGTTSLVMTIARQLSVPGNL 331
Cdd:cd06180 239 LFGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVGVLLPLLSPGPAGLVLSAVLFGGTFMAITALVMALARELAPPAAP 318
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 16132153 332 NLLGFVTLIYGIGQILGPALTSMLSNGTSALASATLCGAAALFIAALISTVQL 384
Cdd:cd06180 319 RALALMTASFGVGQILGPLLAGWLADATGGFAPALILAAAALVVAALLALLVL 371
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
20-367 |
3.03e-16 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 79.39 E-value: 3.03e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 20 MLVLTLGMGLGRFLYTPMLPVMMAEGSFSFSQLSWIASGNYAGYLAGSLLFSFGAFHQPsrLRPFLLASALASGLLILAM 99
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFG--RRPVLLLGLLLFALGALLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 100 AWLPPFILVLLIRVLAGVASAGMLIFGSTLIMQHT---RHPFVLAALFSGVGIGIALGNE-YVLAGLHFDLSSQTLWQGA 175
Cdd:cd06174 79 AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFperERGRALGLLQAFGSVGGILGPLlGGILASSLGFGWRAVFLIA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 176 GALSGMMLIALTLLMPSKKHAI----------TPMPLAKTEQQIMSWWLLAILYGLAGFGYIIVATYLPLMAKDAG--SP 243
Cdd:cd06174 159 AALALLAAILLLLVVPDPPESArakneeasskSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGglSV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 244 LLTAHLWTLVGLSIVPGCFGW-LWAAKRWGALPCLTANLLVQAICVLLTLASDSPLLLIISSLGFGGTFMGTTSLVMTIA 322
Cdd:cd06174 239 AVAGLLLSLFGLAGALGSLLLgLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALI 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 16132153 323 RQLSVPGNLN-LLGFVTLIYGIGQILGPALTSMLSNGTSALASATL 367
Cdd:cd06174 319 AELFPPEIRGtAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFL 364
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
16-347 |
5.34e-14 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 72.31 E-value: 5.34e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 16 ALFGMLVLTLGMGLGRFLYTPMLPVMMAEGSFSFSQLSWIASGNYAGYLAGSLLFsfGAFHQPSRLRPFLLASALASGLL 95
Cdd:COG2814 11 ALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLA--GRLADRFGRRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 96 ILAMAWLPPFILVLLIRVLAGVASAGMLIFGSTLIMQHT---RHPFVLAALFSGVGIGIALGneYVLAGLHFDLSS-QTL 171
Cdd:COG2814 89 SLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVppeRRGRALGLLGAGLGLGPALG--PLLGGLLADLFGwRWV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 172 WQGAGALSGMMLIALTLLMPSKKHAITPMPLAKTEQQIM--SWWLLAILYGLAGFGYIIVATYLPLMAKDAG--SPLLTA 247
Cdd:COG2814 167 FLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRrpRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLglSASAAG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 248 HLWTLVGLSIVPGCFGWLWAAKRWGALPCLTANLLVQAICVLLTLASDSPLLLIISSLGFGGTFMGTTSLVMTIARQLSV 327
Cdd:COG2814 247 LLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAP 326
|
330 340
....*....|....*....|.
gi 16132153 328 PGNLNL-LGFVTLIYGIGQIL 347
Cdd:COG2814 327 PEARGRaSGLYNSAFFLGGPL 347
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
15-365 |
7.66e-11 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 62.98 E-value: 7.66e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 15 TALFGMLVLTLGMGlGRFLYTPMLPVMMAEGSFSFSQLSWIASGNYAGYLAGSLLFS-----FGAfhqpsrlRPFLLASA 89
Cdd:COG2223 6 VLLLATLAFFLAFG-VWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGflvdrFGP-------RRVLLIGL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 90 LASGLLILAMAWLPPFILVLLIRVLAGVASAGMLIFGSTLIMQH---TRHPFVLAALFSGVGIGIALGNEYVLAGLHFDL 166
Cdd:COG2223 78 LLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWfppDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 167 SSQTLWQGAGALSGMMLIALTLLMPSKKHAITPMPLAKTEQQIM----SWWLLAILYGLAGFGYIIVATYLPLMAKDAG- 241
Cdd:COG2223 158 WRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEAlrdpRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFg 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 242 -SPLLTAHLWTLVGLSIVPGCFGWLWAAKRWGALPCLTANLLVQAIC-VLLTLASDSPLLLIISSLGFGGTFMGTTSLVM 319
Cdd:COG2223 238 lSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGlLLLALALGSLWLFLVLFLLLGLALGGGNGAVF 317
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 16132153 320 TIARQLSVPGNLN-LLGFVTLIYGIGQILGPALTSMLSNGTSALASA 365
Cdd:COG2223 318 ALVPDIFPTKNAGaVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAA 364
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
16-360 |
1.17e-10 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 62.58 E-value: 1.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 16 ALFGMLVLTLGMGLGRFLYTPMLPVMMAEGSFSFSQLSWIASGNYAGYLAGSLLfsFGAFHQPSRLRPFLLASALASGLL 95
Cdd:COG2271 11 ILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIP--AGLLADRFGRRRVLAIGLLLWGLA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 96 ILAMAWLPPFILVLLIRVLAGVASAGMLIFGSTLIMQHT---RHPFVLAALFSGVGIGIALGNeyVLAGLhfdLSSQTLW 172
Cdd:COG2271 89 TLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFppkERGRALGIFNAGGPLGGALAP--PLLGW---LLAAFGW 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 173 QGAGALSGMMLIALTLLMpskkhaitpmplakteqqimsWWLLAILYGLAGFGYIIVATYLPLMAKDAG--SPLLTAHLW 250
Cdd:COG2271 164 RAAFLILGLPGLLLALLR---------------------FWLLALAYFLVYFALYGFLTWLPTYLVEVRglSLAQAGLLL 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 251 TLVGLSIVPGCFGWLWAAKRWGALPCLT--ANLLVQAICVLLTLASDSPLLLIISSLGFGGTFMGTTSLVMTIARQLSVP 328
Cdd:COG2271 223 SLPFLAGIVGSLLGGWLSDRLGRRRKLVlaIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPK 302
|
330 340 350
....*....|....*....|....*....|...
gi 16132153 329 GNLNL-LGFVTLIYGIGQILGPALTSMLSNGTS 360
Cdd:COG2271 303 KARGTaSGLVNTFGFLGGALGPLLVGYLLDATG 335
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
16-355 |
8.12e-10 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 59.89 E-value: 8.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 16 ALFGMLVLTLGMGLGRFLYTPMLPVMMAEGSFSFSQLSWIASGNYAGYLAGSLLFsfGAFHQPSRLRPFLLASALASGLL 95
Cdd:COG2807 19 LLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLA--PRLARRFGLERTLLLALLLLAAG 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 96 ILAMAWLPPFILVLLIRVLAGVASAGMLIFGSTLIMQH--TRHPFVLAALFSGVGIGIALGneyvlAGLHFDLSSQTLWQ 173
Cdd:COG2807 97 LLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWfpDRVGLMTGLYTAAMGLGAALA-----AGLTVPLAAALGWR 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 174 GA-GALSGMMLIALTLLMPSKKHAITPMPLAKTEQQIMSW------WLLAILYGLAGFGYIIVATYLPLMAKDAG-SPLL 245
Cdd:COG2807 172 GAlAVWALLALLALLLWLPLLRRRPAAAAAAPAAASLRSLwrsplaWLLTLFFGLQSLLYYAVVAWLPPILRDAGlSAAT 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 246 TAHLWTLVGLSIVPGCFGWLWAAKRWGALPCLTANLLVQAICVLLTLASDSPLLLIISSLGFGGTFMGTTSLVMTIARQL 325
Cdd:COG2807 252 AGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLR 331
|
330 340 350
....*....|....*....|....*....|..
gi 16132153 326 SVPGNLN--LLGFVTLIYGIGQILGPALTSML 355
Cdd:COG2807 332 ARTPAEAaaLSGMAQSVGYLLAALGPLLVGAL 363
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
17-369 |
1.98e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 55.66 E-value: 1.98e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 17 LFGMLVLTLGMGLgrflYTPMLPVMMAEGSFSFSQLSWIASGNYAGYLAGSLLFsfGAFHQPSRLRPFLLASALASGLLI 96
Cdd:cd17325 2 SLALFLDMLGYGI----IIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPA--GRLSDRFGRKRLLLLGLLLLAVST 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 97 LAMAWLPPFILVLLIRVLAGVASAGMLIFGSTLIMQHTRH---PFVLAALFSGVGIGIALGNeyVLAGLHFDLSS-QTLW 172
Cdd:cd17325 76 LLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPeerGRAMGIFSSAIGLGFLIGP--LLGGLLADALGyRAPF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 173 QGAGALSGMMLIALTLLMP-----SKKHAITPMPLAKTEQQIMSWWLLAILYG---LAGFGYIIVATYLPLMAKDAG--S 242
Cdd:cd17325 154 LVCAALALLALVLALLLLPeprppPNKRAVSAARLRSGLRLLLRDRRLLALFLaifVLAFAFGALEPFLPLYAAELGglS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 243 PLLTAHLWTLVGLSIVPGCFGWLWAAKRWGALPCLTANLLVQAICVLLTLASDSPLLLIISSLGFGGTFMGTTSLVMTIA 322
Cdd:cd17325 234 PAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALL 313
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 16132153 323 RQLSVPGNL-NLLGFVTLIYGIGQILGPALTSMLSNGTSALASATLCG 369
Cdd:cd17325 314 ADIVPPEGRgTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAA 361
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
20-349 |
1.58e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 52.81 E-value: 1.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 20 MLVLTLGMGLGRFLYTPMLPVMMAEG-SFSFSQLSWIASGNYAGYLAGSLLFsfGAFHQPSRLRPFLLASALASGLLILA 98
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDlGISPTEIGLLLTLFSLGYALAQPLA--GRLSDRFGRRRVLLIGLLLFALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 99 MAWLPPFILVLLIRVLAGVASAGMLIFGSTLIMQHT---RHPFVLAALFSGVGIGIALGNeYVLAGLHFDLSSQTLWQGA 175
Cdd:pfam07690 79 LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFppeERGRALGLVSAGFGLGAALGP-LLGGLLASLFGWRAAFLIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 176 GALSGMMLIALTLLMPSKKHAITPMPLAKTEQQIMSW--------WLLAILYGLAGFGYIIVATYLPLMAKDAG-SPLLT 246
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWkallrdpvLWLLLALLLFGFAFFGLLTYLPLYQEVLGlSALLA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 247 AHLWTLVGLSIVPGCFGWLWAAKRWGALPCLTANLLVQAICVL---LTLASDSPLLLIISSLGFGGTFMGTTSLVMTIAR 323
Cdd:pfam07690 238 GLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALgllLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVS 317
|
330 340
....*....|....*....|....*..
gi 16132153 324 QLSVPGNLN-LLGFVTLIYGIGQILGP 349
Cdd:pfam07690 318 DLAPKEERGtASGLYNTAGSLGGALGP 344
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
17-355 |
1.74e-07 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 52.55 E-value: 1.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 17 LFGMLVLTLGMGLGRFLYTPMLPVMMAEGSFSFSQLSWIASGNYAGYLAGSLLFsfGAFHQPSRLRPFLLASALASGLLI 96
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLL--GPLSDRIERRRLLLVLLLLFILGN 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 97 LAMAWLPPFILVLLIRVLAGVASAGMLIFGSTLIMQHT---RHPFVLAALFSGVGIGIALGNeyVLAGLHFDLSS-QTLW 172
Cdd:cd17324 79 LLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVppeKRGRAIGLVFSGLTLGLVLGR--PLGGLLGQLLGwRAAF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 173 QGAGALSGMMLIALTLLMPSKKHAiTPMPLAKTEQQIMSW-----WLLAILYGLAGFGYIIVATYLPLMAKDA--GSPLL 245
Cdd:cd17324 157 LAIAVLALLAALLLWRLLPSLPPK-KPGSLGLLSSLLLLLrnprlRLAYLITFLLFGGFFALYTYLAPFLTDVpgFSSSA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 246 TAHLWTLVGLSIVPGCFGWLWAAKRWGALPCLTANLLVQAICVLLTLASDSPLLLIISSLGFGGTFMGTTSLVMTIARQL 325
Cdd:cd17324 236 IIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL 315
|
330 340 350
....*....|....*....|....*....|
gi 16132153 326 SVPGNLNLLGFVTLIYGIGQILGPALTSML 355
Cdd:cd17324 316 APEARGLASSLYLAAYNLGGALGAALGGLV 345
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
81-351 |
7.07e-07 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 50.73 E-value: 7.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 81 LRPFLLASALASGLLILAMAWLP-PFILVLLIRVLAGVASAGM---LIFGSTLIMQHTRHPFVLAALFSGVGIGIALGNE 156
Cdd:cd17355 67 PRRVMLLGLLLLAAGLVLLALATsLWQLYLLWGLLGGGGAGTLaavAFATVAAWWFERRRGLALGILTAGGGLGSLVFLP 146
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 157 YVLAGLHFDLSSQTLWQGAGALSGMMLIALTLLMPSK-------KHAITPMPLAKTEQQIM---SWWLLAILYGLAGFG- 225
Cdd:cd17355 147 LGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRPadlalraYDDASPASPGSTLKEALrsaSFWLLALAFFLCGFAv 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 226 YIIVATYLPLMAKDAGSPLLTAHLWTLVGLSIVPGCFGWLWAAKRWGALPCLTANLLVQAI-CVLLTLASDSPLLLIISS 304
Cdd:cd17355 227 VGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALgLALLLLLPFPPLALLLFA 306
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 16132153 305 LGFGGTFMGTTSLVMTIARQLSVPGNLNLL-GFVTLIYGIGQILGPAL 351
Cdd:cd17355 307 ALFGLGWGATVPLTAALAARYFGARSYGTLfGLVFAPHQLGSALGPWL 354
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
16-355 |
4.12e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 48.32 E-value: 4.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 16 ALFGMLVLTLGMGLgrflYTPMLPVMMAEGSFSFSQLSWIASGNYAGYLAGSLLfsFGAFHQPSRLRPFLLASALASGLL 95
Cdd:cd17477 1 LLLSVALLGLGSGL----LLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPL--VPRLIRRVGHIRAFAAGAAITAVS 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 96 ILAMAWLPPFILVLLIRVLAGVASAGMLIFGSTLIMQHTRHPF---VLAALFSGVGIGIALGNeyvLAGLHFDLSSQTLW 172
Cdd:cd17477 75 VLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALATNENrgrVLGLYSTVLGLGFALGP---LLLALVGTAGALPF 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 173 QGAGALSGMMLIALtLLMPSKKHAITPMPLAKTEQQIMSWWLLAILYGLAGFGYIIVATYLPLMAKDAGSPLLTAHLWTL 252
Cdd:cd17477 152 LIAAVLLLLALVPL-LLTRRAAPEIEEAESISLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 253 VGLsIVPGCFGWL--WAAKRWGALPCLTANLLVQAIC-VLLTLASDSPLLLIISSLGFGGTFMGTTSLVMTIARQLSVPG 329
Cdd:cd17477 231 AFV-LGGLLLQWPlgWLADRFDRRRVLLGCALLGALAaLLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGD 309
|
330 340
....*....|....*....|....*..
gi 16132153 330 NL-NLLGFVTLIYGIGQILGPALTSML 355
Cdd:cd17477 310 ELvAANAALLLLYGLGSVIGPLLAGAL 336
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
80-355 |
2.64e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 42.97 E-value: 2.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 80 RLRPFLLASALASGLLILAMAWLPP------FILVLLIRVLAGVASAGMLIFGSTLIMQHTRHP------FVLAALFSGV 147
Cdd:COG2211 79 RRRPWILIGAIPLALSFVLLFTAPDlsptgkLIYALVTYLLLGLAYTLVNIPYSALGAELTPDYeertrlSSWRFAFAGL 158
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 148 GIGIALGNEYVLAGLHFDLSSQTLWQGAGALSGMMLIALTLLMPSKKHAITP----MPLAKTEQQIMS---WWLLAILYG 220
Cdd:COG2211 159 GGLLASVLPPPLVAAFGGDAALGYRLTALIFAVLGLLAFLLTFFGTKERPVPeeekVSLKESLKALLKnrpFLLLLLAYL 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 221 LAGFGYIIVATYLPLMAKDA--GSPLLTAHLWTLVGLSIVPGCFGWLWAAKRWGALPCLTANLLVQAICVLLTLASDSP- 297
Cdd:COG2211 239 LFFLALALVAALLLYYFKYVlgLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGn 318
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 16132153 298 -----LLLIISSLGFGGTFMGTTSLVMTIARQLSVPGNLN----LLGFVTLIYGIGQILGPALTSML 355
Cdd:COG2211 319 lwlllVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRreglYFGIFTFAIKLGQALAGALAGLL 385
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
36-364 |
4.77e-04 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 41.76 E-value: 4.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 36 PMLPVMMAEGSFSFSQLSWIASGNYAGYLAGSLLfsFGAFHQPSRLRPFLLASALASGLLILAMAWLPPFILVLLIRVLA 115
Cdd:COG0738 29 PLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLP--AGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 116 GVASAGMLIFGSTLI--MQHTRHPFVLAALFSGVGIGIALGneYVLAGLHFDLSSQTLWQGA-GALSGMMLIALTLLMPS 192
Cdd:COG0738 107 GLGLGLLDVAANPYVaaLGPETAASRLNLLHAFFSLGALLG--PLLGGLLILLGLSLSWHLPyLILAVLLLLLALLFLRS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 193 KKHAITPMPLAKTEQQIMSWWLLA----ILYGLAGFGY----IIVATYLPLMAKDAG--SPLLTAHLWTLVGLSIVPGCF 262
Cdd:COG0738 185 KLPEIEEEEEEAAGSAASLKSLLKnprlLLGGLAIFLYvgaeGAIGDWLPLYLKDVLglSEATAALGLSLFWGGMTIGRF 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 263 GWLWAAKRWGALPCLTANLLVQAICVLLTLASDSPLLLIISSLGFGGTFMGTTSLVMTIARQLSVPGNLNLLGFVTLIYG 342
Cdd:COG0738 265 LGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGI 344
|
330 340
....*....|....*....|..
gi 16132153 343 IGQILGPALTSMLSNGTSALAS 364
Cdd:COG0738 345 VGGAIGPPLIGFLADAFGLRAA 366
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
33-351 |
1.13e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 40.62 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 33 LYTPMLPVMMAEGSFSFSQLSWIASgnyAGYLAGSLLFS-FGAFHQPSRLRPFLLASALASGLLILAMAWLPPFILVLLI 111
Cdd:cd17478 14 FLPALLPLLIAKLGLSYAQAGLLVS---VFSITSSLLQPlFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 112 RVLAGVASAGMLIFGSTLIMQ--HTRHPFVLAALFSGVGIGIALGNeyVLAGLHFDLSSQTLWQGAGALSGMMLIALTLL 189
Cdd:cd17478 91 VALAGIGSAAFHPEGARLASQaaGGRRGLAMSIFSVGGNLGFALGP--LIAAALVALFGGLGLLILLIIPGLAVALLLLR 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 190 MPSKKHAITPMPLAKTEQQ------IMSWWLLAILYGLAGFGYIIVATYLPLMAKDAGSPLLTAHLwtLVGLSIVPGCFG 263
Cdd:cd17478 169 LRPLKKPEAKKAAAKSSARstlkgvWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGL--LLSLFLFAGAIG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 264 WL---WAAKRWGALPCLTANLLVQAICVLLTLASDSPLLLIISSLgFGGTFMGTTSLVMTIARQLsVPGNLNLLG--FVT 338
Cdd:cd17478 247 TLiggPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVL-AGFLLFASFPVTVVLAQEL-LPGNVGLASglMMG 324
|
330
....*....|...
gi 16132153 339 LIYGIGQILGPAL 351
Cdd:cd17478 325 LSFGLGGIGAPVL 337
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
36-356 |
1.17e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 40.64 E-value: 1.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 36 PMLPVMMAEGSFSFSQLSWIASGNYAGYLAGSLLFSFGAfHQPSRLRPFLLASALASGLLILAMAWLPP-FILVLLIRVL 114
Cdd:cd17335 18 PFLSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALA-DRFGKRKALLLLSLLAAVLFFLSLFFVAQiFWLLLLLVIL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 115 AGVASAGMLIFGSTLIMQH---TRHPFVLAALFSGVGIGI-ALGNEYVLAGLHFDLSSQTLWQGAGALSGMMLIALTLLM 190
Cdd:cd17335 97 GAFFSAPVVPLVDSITLQYlgeERERYGKQRLWGSIGFGIaALLVGILIDRSSTYKNYTIAFYVFAVLMLLALLLALKFP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 191 PSKKHAITPMPLAKTEQQIMSW--WLLAILYGLAGFGYIIVATYLPLMAKDAG-SPLLTAHLWTLVGLSIVPGCFGWLWA 267
Cdd:cd17335 177 FRPKHPEPNENTGGLLALLRNPrvLAFLLVAFLMGFGHGLIYSFLFWHLQDLGgSKTLIGLLWTVGVVSEIPFFFFSSRL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 268 AKRWGALPCLTANLLVQAICVLLTLASDSPLLLIISSLGFGGTFMGTTSLVMTIARQLSVPGNLNLLGfvTLIYGIGQIL 347
Cdd:cd17335 257 IQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAAPPGLRATAQ--GLLQGLYFGL 334
|
....*....
gi 16132153 348 GPALTSMLS 356
Cdd:cd17335 335 GGGLGSLIG 343
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
80-360 |
3.54e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 39.13 E-value: 3.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 80 RLRPFLLASALASGLLILAMAWLPPFILVLLIRVLAGVASAG----MLIFGSTLIMQHTRHPFVLAALFSGVGIGIAlgn 155
Cdd:cd17490 60 KRKLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGIAAATwvsfTVLYASYFPPDEAAKAMGLINLVNNLGQLIA--- 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 156 eYVLAGLHFDLSSQTLWQGAGALSGmmLIALTLLMPSKKHAITPMPLAKTEQQIMS------WWLLAILYGLA-GFGYII 228
Cdd:cd17490 137 -FLIGGLIAEHFGMRAPFLLAALAG--VLGFILSLFIKEERREKKPVLTELKELLSvlkdkkLLFFSLLAILQqMITFST 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 229 VATYLPLMAKDAGSPllTAHLWTLVGLSIVPG----CFGWLWAAKRWGALPCLTANLLVQAICVLLT-LASDSPLLLI-- 301
Cdd:cd17490 214 TFGFTPLIAKQLGAS--SFQLGLLSIIYLLPNalasLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIpFAPNLTLLYLlq 291
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 16132153 302 -ISSLGFGGTFMGTTSLVMTiarqlSVPGNL--NLLGFVTLIYGIGQILGPALTSMLSNGTS 360
Cdd:cd17490 292 aLNGFGTGILFPLLMSLSIE-----GVPAEQrsTAMGFFQAIYALGMFLGPVLVGIISEAFG 348
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
32-321 |
4.78e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 38.74 E-value: 4.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 32 FLYTPMLPVMMAEGSF--SFSQLSWIASGNYAGYLAGSLLFSFGAfhqpSRL--RPFLLASALASGLLILAMAWLPPFIL 107
Cdd:cd17316 16 FLIGFVAPVLAAEFSLglSLLQTGLLFAAGFLGRPIGALLFGYLG----DRIgrKKALILTLLLFGLATLLIGLLPTPIL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 108 VLLIRVLAGVASAGMLIFGSTLIMQHT---RHPFVLAALFSGVGIGIALGNeYVLAGLHFDLSSQTLWQGAGALSGMMLI 184
Cdd:cd17316 92 LLVLRFLQGIGIGGEYPGASTYVAEFApskRRGFALGLLQSGWALGALLAA-LVASLLIPLLSGDWGWRILFLIGALPAL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 185 ALTLLMpskkhaitpmplakteqqiMSWWLLAILYGLAGFGYIIVATYLP--LMAKDAGSPLLTAHLWTLVGLSIVPGCF 262
Cdd:cd17316 171 LALLLR-------------------RRTLLLILLWFFISFGYYGLTTFLPtyLQTVLGLSPATSSLYLLLISLGALVGAL 231
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 16132153 263 GWLWAAKRWGALPCLTANLLVQAICVLLT--LASDSPLLLIISSLGFGGTFMGTTSLVMTI 321
Cdd:cd17316 232 IAGLLSDRIGRKKTLVIGLILSGILALPLfyLLSGSPTLLLLLLFILSFFVGGVWGALYAY 292
|
|
| MFS_SLCO_OATP |
cd17336 |
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ... |
46-162 |
8.80e-03 |
|
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340894 [Multi-domain] Cd Length: 411 Bit Score: 37.99 E-value: 8.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16132153 46 SFSFSQLSWIASGNYAGYLAGSLLFS-FGafHQPSRLRpFLLASALASGLLILAMAwLPPFILVLLIrvLAGVASAGMLI 124
Cdd:cd17336 34 GLSSSQSGLILSANDIGQLLAVLLVSyFG--GRGHRPR-WIGIGSILMGLGCFLLA-LPHFLFVGQF--LLGIGSSPLYT 107
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 16132153 125 FGSTLIMQHTRH---PFVLAALFSGVGIGIALGneYVLAGL 162
Cdd:cd17336 108 LGITYIDDNVSKknsPLYIGILYAMRVLGPALG--FLLGSF 146
|
|
| |
