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Conserved domains on  [gi|18087789|ref|NP_444368|]
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protocadherin beta-6 precursor [Mus musculus]

Protein Classification

protocadherin( domain architecture ID 11175748)

protocadherin may have tightly regulated functions in the development, regionalization, and functional differentiation of the central nervous system

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172|18430161
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 29-111 2.96e-42

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 148.06  E-value: 2.96e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789    29 SIQYAMLEETESGTFVANLTKHLGLRVGELAARDARVVFKGNRQYLQLDPQTQDLMLNENLDREELCGSTEPCVLSFRVL 108
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 18087789   109 LKN 111
Cdd:pfam08266  81 LEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-341 4.04e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.81  E-value: 4.04e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789 246 YEVQVPENSPIGSLLITVSARDLDAGPFGEVSYGLSQDDDvNEPFEINTKTGEIRLKSTLDFEAFQSYHVDVEALDGGG- 324
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                        90
                ....*....|....*...
gi 18087789 325 -LTGKCSLVVQVLDVNDN 341
Cdd:cd11304  81 pLSSTATVTITVLDVNDN 98
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 686-765 4.74e-29

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


:

Pssm-ID: 465139  Cd Length: 84  Bit Score: 110.69  E-value: 4.74e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789   686 LTLYLVIALASVSSLFLLSVVLFVGVRLCKKFRAASLGG----YSVPEGHFPGHlvdvSGAGTLSQSYQYEVCLRGDTGT 761
Cdd:pfam16492   2 LTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSsgnlCSVPAPHFPGN----DGTGTLPQSYSYEVCLTSDSGK 77


                  ....
gi 18087789   762 GEFK 765
Cdd:pfam16492  78 SEFK 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 354-445 2.77e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 2.77e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789 354 IPENLP-GIIVAVFSVSDADSGNNQQVMCSI---DDNLPFLLRPsmeNFYTLETDGALDRESRSEYNITITVTDMGTPRL 429
Cdd:cd11304   6 VPENAPpGTVVLTVSATDPDSGENGEVTYSIvsgNEDGLFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                        90
                ....*....|....*.
gi 18087789 430 TTQHNITVQVSDINDN 445
Cdd:cd11304  83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-237 2.01e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.29  E-value: 2.01e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789 139 LKISEIAPPGKIFPLKMAQDLDTGSHSIQSYTVSDNP---HFHVltrNRSDGkkfpELVLDKALDREKQDQLRLKLTAVD 215
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNedgLFSI---DPSTG----EITTAKPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|..
gi 18087789 216 GGSPPRSGTTEIQILVLDINDN 237
Cdd:cd11304  77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 574-662 3.25e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.21  E-value: 3.25e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789 574 LPRAAEPGYLVTKVVAVDRDSGQNAWLSFQLFKATEPGLFSVWAHNGEVRTTRLLSERDVPKHRLLLLVKDNGEPPRSAS 653
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSST 85


                ....*....
gi 18087789 654 VTLHVLLVD 662
Cdd:cd11304  86 ATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 453-555 4.39e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.83  E-value: 4.39e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789 453 SYTLFVHENNSPALHIGTISATDSDSGSNAHITYSLLLPQDKqltltSLVSINADNGQLFALRALDYEALQAFEFRVDAT 532
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED-----GLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 18087789 533 DQGSPALSSQVLVRVVVLDDNDN 555
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 29-111 2.96e-42

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 148.06  E-value: 2.96e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789    29 SIQYAMLEETESGTFVANLTKHLGLRVGELAARDARVVFKGNRQYLQLDPQTQDLMLNENLDREELCGSTEPCVLSFRVL 108
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 18087789   109 LKN 111
Cdd:pfam08266  81 LEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-341 4.04e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.81  E-value: 4.04e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789 246 YEVQVPENSPIGSLLITVSARDLDAGPFGEVSYGLSQDDDvNEPFEINTKTGEIRLKSTLDFEAFQSYHVDVEALDGGG- 324
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                        90
                ....*....|....*...
gi 18087789 325 -LTGKCSLVVQVLDVNDN 341
Cdd:cd11304  81 pLSSTATVTITVLDVNDN 98
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 686-765 4.74e-29

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 110.69  E-value: 4.74e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789   686 LTLYLVIALASVSSLFLLSVVLFVGVRLCKKFRAASLGG----YSVPEGHFPGHlvdvSGAGTLSQSYQYEVCLRGDTGT 761
Cdd:pfam16492   2 LTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSsgnlCSVPAPHFPGN----DGTGTLPQSYSYEVCLTSDSGK 77


                  ....
gi 18087789   762 GEFK 765
Cdd:pfam16492  78 SEFK 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 354-445 2.77e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 2.77e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789 354 IPENLP-GIIVAVFSVSDADSGNNQQVMCSI---DDNLPFLLRPsmeNFYTLETDGALDRESRSEYNITITVTDMGTPRL 429
Cdd:cd11304   6 VPENAPpGTVVLTVSATDPDSGENGEVTYSIvsgNEDGLFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                        90
                ....*....|....*.
gi 18087789 430 TTQHNITVQVSDINDN 445
Cdd:cd11304  83 SSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 264-343 3.05e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 91.26  E-value: 3.05e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789    264 SARDLDAGPFGEVSYGLSQDDDvNEPFEINTKTGEIRLKSTLDFEAFQSYHVDVEALDGGG--LTGKCSLVVQVLDVNDN 341
Cdd:smart00112   1 SATDADSGENGKVTYSILSGND-DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDN 79


                   ..
gi 18087789    342 AP 343
Cdd:smart00112  80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-237 2.01e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.29  E-value: 2.01e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789 139 LKISEIAPPGKIFPLKMAQDLDTGSHSIQSYTVSDNP---HFHVltrNRSDGkkfpELVLDKALDREKQDQLRLKLTAVD 215
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNedgLFSI---DPSTG----EITTAKPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|..
gi 18087789 216 GGSPPRSGTTEIQILVLDINDN 237
Cdd:cd11304  77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 574-662 3.25e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.21  E-value: 3.25e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789 574 LPRAAEPGYLVTKVVAVDRDSGQNAWLSFQLFKATEPGLFSVWAHNGEVRTTRLLSERDVPKHRLLLLVKDNGEPPRSAS 653
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSST 85


                ....*....
gi 18087789 654 VTLHVLLVD 662
Cdd:cd11304  86 ATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 453-555 4.39e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.83  E-value: 4.39e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789 453 SYTLFVHENNSPALHIGTISATDSDSGSNAHITYSLLLPQDKqltltSLVSINADNGQLFALRALDYEALQAFEFRVDAT 532
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED-----GLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 18087789 533 DQGSPALSSQVLVRVVVLDDNDN 555
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
246-336 4.40e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.43  E-value: 4.40e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789   246 YEVQVPENSPIGSLLITVSARDLDAGPFGEVSYGLSQDDdVNEPFEINTKTGEIRLKSTLDFEAFQSYHVDVEALDGG-- 323
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGG-PGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgp 79

                          90
                  ....*....|...
gi 18087789   324 GLTGKCSLVVQVL 336
Cdd:pfam00028  80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 156-239 3.09e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.78  E-value: 3.09e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789    156 AQDLDTGSHSIQSYTVSDNPHFHVLTRNRSDGkkfpELVLDKALDREKQDQLRLKLTAVDGGSPPRSGTTEIQILVLDIN 235
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDGLFSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 18087789    236 DNTP 239
Cdd:smart00112  78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 367-447 2.56e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 2.56e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789    367 SVSDADSGNNQQVMCSI---DDNLPFLLRPsmeNFYTLETDGALDRESRSEYNITITVTDMGTPRLTTQHNITVQVSDIN 443
Cdd:smart00112   1 SATDADSGENGKVTYSIlsgNDDGLFSIDP---ETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 18087789    444 DNAP 447
Cdd:smart00112  78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 588-662 1.25e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.69  E-value: 1.25e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18087789    588 VAVDRDSGQNAWLSFQLFKATEPGLFSVWAHNGEVRTTRLLSERDVPKHRLLLLVKDNGEPPRSASVTLHVLLVD 662
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 472-557 2.02e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 2.02e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789    472 SATDSDSGSNAHITYSLLLPQDKqltltSLVSINADNGQLFALRALDYEALQAFEFRVDATDQGSPALSSQVLVRVVVLD 551
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDD-----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 18087789    552 DNDNAP 557
Cdd:smart00112  76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
454-541 3.30e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.78  E-value: 3.30e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789   454 YTLFVHENNSPALHIGTISATDSDSGSNAHITYSLL-LPQDKQLTltslvsINADNGQLFALRALDYEALQAFEFRVDAT 532
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILgGGPGGNFR------IDPDTGDISTTKPLDRESIGEYELTVEAT 74


                  ....*....
gi 18087789   533 DQGSPALSS 541
Cdd:pfam00028  75 DSGGPPLSS 83
Cadherin pfam00028
Cadherin domain;
354-439 1.18e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.24  E-value: 1.18e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789   354 IPENLP-GIIVAVFSVSDADSGNNQQVMCSIddnlpflLRPSMENFYTLETD-------GALDRESRSEYNITITVTDMG 425
Cdd:pfam00028   5 VPENAPvGTEVLTVTATDPDLGPNGRIFYSI-------LGGGPGGNFRIDPDtgdisttKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....
gi 18087789   426 TPRLTTQHNITVQV 439
Cdd:pfam00028  78 GPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
141-232 6.06e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 59.62  E-value: 6.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789   141 ISEIAPPGKIFPLKMAQDLDTGSHSIQSYTVSDNPHFHVLTRNRSDGkkfpELVLDKALDREKQDQLRLKLTAVDGGSPP 220
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTG----DISTTKPLDRESIGEYELTVEATDSGGPP 80

                          90
                  ....*....|..
gi 18087789   221 RSGTTEIQILVL 232
Cdd:pfam00028  81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
574-660 9.13e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.85  E-value: 9.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789   574 LPRAAEPGYLVTKVVAVDRDSGQNAWLSFQLFKATEPGLFSVWAHNGEVRTTRLLSERDVPKHRLLLLVKDNGEPPRSAS 653
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                  ....*..
gi 18087789   654 VTLHVLL 660
Cdd:pfam00028  85 ATVTITV 91
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 30-128 3.62e-09

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 54.66  E-value: 3.62e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789  30 IQYAMLEETESGTFVANLTKHLGlrvgELAARDARVVFKGNR---QYLQLDPQTQDLMLNENLDREELcgstepCVLSFR 106
Cdd:cd00031   2 PDGSAVEGRSRGSFRVSIPTDLI----ASSGEIIKISAAGKEalpSWLHWEPHSGILEGLEKLDREDK------GVHYIS 71

                        90       100
                ....*....|....*....|....*..
gi 18087789 107 VLLKN-----PLQFYQAELRVIDINDH 128
Cdd:cd00031  72 VSAASlganvPQTSSVFSIEVYDENDN 98
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 29-111 2.96e-42

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 148.06  E-value: 2.96e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789    29 SIQYAMLEETESGTFVANLTKHLGLRVGELAARDARVVFKGNRQYLQLDPQTQDLMLNENLDREELCGSTEPCVLSFRVL 108
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 18087789   109 LKN 111
Cdd:pfam08266  81 LEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-341 4.04e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.81  E-value: 4.04e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789 246 YEVQVPENSPIGSLLITVSARDLDAGPFGEVSYGLSQDDDvNEPFEINTKTGEIRLKSTLDFEAFQSYHVDVEALDGGG- 324
Cdd:cd11304   2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNE-DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGp 80

                        90
                ....*....|....*...
gi 18087789 325 -LTGKCSLVVQVLDVNDN 341
Cdd:cd11304  81 pLSSTATVTITVLDVNDN 98
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 686-765 4.74e-29

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 110.69  E-value: 4.74e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789   686 LTLYLVIALASVSSLFLLSVVLFVGVRLCKKFRAASLGG----YSVPEGHFPGHlvdvSGAGTLSQSYQYEVCLRGDTGT 761
Cdd:pfam16492   2 LTFYLVIALASVSFLFLLFVIVLIALRLRRWRSSALLQSsgnlCSVPAPHFPGN----DGTGTLPQSYSYEVCLTSDSGK 77


                  ....
gi 18087789   762 GEFK 765
Cdd:pfam16492  78 SEFK 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 354-445 2.77e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.99  E-value: 2.77e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789 354 IPENLP-GIIVAVFSVSDADSGNNQQVMCSI---DDNLPFLLRPsmeNFYTLETDGALDRESRSEYNITITVTDMGTPRL 429
Cdd:cd11304   6 VPENAPpGTVVLTVSATDPDSGENGEVTYSIvsgNEDGLFSIDP---STGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                        90
                ....*....|....*.
gi 18087789 430 TTQHNITVQVSDINDN 445
Cdd:cd11304  83 SSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 264-343 3.05e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 91.26  E-value: 3.05e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789    264 SARDLDAGPFGEVSYGLSQDDDvNEPFEINTKTGEIRLKSTLDFEAFQSYHVDVEALDGGG--LTGKCSLVVQVLDVNDN 341
Cdd:smart00112   1 SATDADSGENGKVTYSILSGND-DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGppLSSTATVTITVLDVNDN 79


                   ..
gi 18087789    342 AP 343
Cdd:smart00112  80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 139-237 2.01e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 89.29  E-value: 2.01e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789 139 LKISEIAPPGKIFPLKMAQDLDTGSHSIQSYTVSDNP---HFHVltrNRSDGkkfpELVLDKALDREKQDQLRLKLTAVD 215
Cdd:cd11304   4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNedgLFSI---DPSTG----EITTAKPLDREEQSSYTLTVTATD 76

                        90       100
                ....*....|....*....|..
gi 18087789 216 GGSPPRSGTTEIQILVLDINDN 237
Cdd:cd11304  77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 574-662 3.25e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.21  E-value: 3.25e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789 574 LPRAAEPGYLVTKVVAVDRDSGQNAWLSFQLFKATEPGLFSVWAHNGEVRTTRLLSERDVPKHRLLLLVKDNGEPPRSAS 653
Cdd:cd11304   6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLSST 85


                ....*....
gi 18087789 654 VTLHVLLVD 662
Cdd:cd11304  86 ATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 453-555 4.39e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.83  E-value: 4.39e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789 453 SYTLFVHENNSPALHIGTISATDSDSGSNAHITYSLLLPQDKqltltSLVSINADNGQLFALRALDYEALQAFEFRVDAT 532
Cdd:cd11304   1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNED-----GLFSIDPSTGEITTAKPLDREEQSSYTLTVTAT 75

                        90       100
                ....*....|....*....|...
gi 18087789 533 DQGSPALSSQVLVRVVVLDDNDN 555
Cdd:cd11304  76 DGGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
246-336 4.40e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.43  E-value: 4.40e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789   246 YEVQVPENSPIGSLLITVSARDLDAGPFGEVSYGLSQDDdVNEPFEINTKTGEIRLKSTLDFEAFQSYHVDVEALDGG-- 323
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGG-PGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGgp 79

                          90
                  ....*....|...
gi 18087789   324 GLTGKCSLVVQVL 336
Cdd:pfam00028  80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 156-239 3.09e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.78  E-value: 3.09e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789    156 AQDLDTGSHSIQSYTVSDNPHFHVLTRNRSDGkkfpELVLDKALDREKQDQLRLKLTAVDGGSPPRSGTTEIQILVLDIN 235
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDGLFSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 18087789    236 DNTP 239
Cdd:smart00112  78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 367-447 2.56e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 2.56e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789    367 SVSDADSGNNQQVMCSI---DDNLPFLLRPsmeNFYTLETDGALDRESRSEYNITITVTDMGTPRLTTQHNITVQVSDIN 443
Cdd:smart00112   1 SATDADSGENGKVTYSIlsgNDDGLFSIDP---ETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 18087789    444 DNAP 447
Cdd:smart00112  78 DNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 588-662 1.25e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.69  E-value: 1.25e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18087789    588 VAVDRDSGQNAWLSFQLFKATEPGLFSVWAHNGEVRTTRLLSERDVPKHRLLLLVKDNGEPPRSASVTLHVLLVD 662
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 472-557 2.02e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 2.02e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789    472 SATDSDSGSNAHITYSLLLPQDKqltltSLVSINADNGQLFALRALDYEALQAFEFRVDATDQGSPALSSQVLVRVVVLD 551
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDD-----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLD 75


                   ....*.
gi 18087789    552 DNDNAP 557
Cdd:smart00112  76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
454-541 3.30e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 65.78  E-value: 3.30e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789   454 YTLFVHENNSPALHIGTISATDSDSGSNAHITYSLL-LPQDKQLTltslvsINADNGQLFALRALDYEALQAFEFRVDAT 532
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILgGGPGGNFR------IDPDTGDISTTKPLDRESIGEYELTVEAT 74


                  ....*....
gi 18087789   533 DQGSPALSS 541
Cdd:pfam00028  75 DSGGPPLSS 83
Cadherin pfam00028
Cadherin domain;
354-439 1.18e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 64.24  E-value: 1.18e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789   354 IPENLP-GIIVAVFSVSDADSGNNQQVMCSIddnlpflLRPSMENFYTLETD-------GALDRESRSEYNITITVTDMG 425
Cdd:pfam00028   5 VPENAPvGTEVLTVTATDPDLGPNGRIFYSI-------LGGGPGGNFRIDPDtgdisttKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....
gi 18087789   426 TPRLTTQHNITVQV 439
Cdd:pfam00028  78 GPPLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
141-232 6.06e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 59.62  E-value: 6.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789   141 ISEIAPPGKIFPLKMAQDLDTGSHSIQSYTVSDNPHFHVLTRNRSDGkkfpELVLDKALDREKQDQLRLKLTAVDGGSPP 220
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTG----DISTTKPLDRESIGEYELTVEATDSGGPP 80

                          90
                  ....*....|..
gi 18087789   221 RSGTTEIQILVL 232
Cdd:pfam00028  81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
574-660 9.13e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 58.85  E-value: 9.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789   574 LPRAAEPGYLVTKVVAVDRDSGQNAWLSFQLFKATEPGLFSVWAHNGEVRTTRLLSERDVPKHRLLLLVKDNGEPPRSAS 653
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSST 84


                  ....*..
gi 18087789   654 VTLHVLL 660
Cdd:pfam00028  85 ATVTITV 91
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 30-128 3.62e-09

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 54.66  E-value: 3.62e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18087789  30 IQYAMLEETESGTFVANLTKHLGlrvgELAARDARVVFKGNR---QYLQLDPQTQDLMLNENLDREELcgstepCVLSFR 106
Cdd:cd00031   2 PDGSAVEGRSRGSFRVSIPTDLI----ASSGEIIKISAAGKEalpSWLHWEPHSGILEGLEKLDREDK------GVHYIS 71

                        90       100
                ....*....|....*....|....*..
gi 18087789 107 VLLKN-----PLQFYQAELRVIDINDH 128
Cdd:cd00031  72 VSAASlganvPQTSSVFSIEVYDENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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