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Conserved domains on  [gi|686661093|ref|NP_445957|]
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sodium/potassium/calcium exchanger 3 [Rattus norvegicus]

Protein Classification

putative sodium/potassium/calcium exchanger( domain architecture ID 1001229)

putative sodium/potassium/calcium exchanger

Gene Ontology:  GO:0005886|GO:0015293|GO:0006811
PubMed:  15163769
TCDB:  2.A.19

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 89-628 1.37e-108

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 352.38  E-value: 1.37e-108
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093    89 PALH---EFPRDIFSNEDRRQGAVVLHVLCAMYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFT 165
Cdd:TIGR00927  434 PDLHpkaEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFT 513

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093   166 SVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVALSSWCLLRDSIYYTLSVVALIVFIYDEKVSWWESLVLVL 245
Cdd:TIGR00927  514 SLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLL 593

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093   246 MYLIYIIIMKYNACIH----QCFERR-----------TKGA-------GNMVNGLAN-----NAEIDDSSNCDA------ 292
Cdd:TIGR00927  594 AYALYVFTMKWNKQIElwvkEQLSRRpvakvmalgdlSKGDvaeaehtGERTGEEGErpteaEGENGEESGGEAeqeget 673

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093   293 -TVVLLK---------------KANFHRKASVIMVDELLSAYPHQLSFSEAGLRimITSHFPPKTRLSMASRMLINERQ- 355
Cdd:TIGR00927  674 eTKGENEsegeipaerkgeqegEGEIEAKEADHKGETEAEEVEHEGETEAEGTE--DEGEIETGEEGEEVEDEGEGEAEg 751

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093   356 RLINSRAYTNGESEVAIKIPIKHTVENGTGPSSAPDRG-VNGTRRDDIVAEADNETENENEDENNENDEEEDEDDDEGPY 434
Cdd:TIGR00927  752 KHEVETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDGeMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDE 831

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093   435 T--------------------------------------------------------------PFDPPSGKLETVKWAFT 452
Cdd:TIGR00927  832 TgeqelnaenqgeakqdekgvdggggsdggdseeeeeeeeeeeeeeeeeeeeeeeeeeneeplSLEWPETRQKQAIYLFL 911

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093   453 WPLSFVLYFTVPNCNKPHWEKWFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVA 532
Cdd:TIGR00927  912 LPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVA 991

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093   533 RQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLaVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGCG 612
Cdd:TIGR00927  992 RKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSL-INGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFT 1070

                          650
                   ....*....|....*.
gi 686661093   613 CLFLYGVFLCFSIMTE 628
Cdd:TIGR00927 1071 MFLLYFVFLIISVMLE 1086
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 89-628 1.37e-108

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 352.38  E-value: 1.37e-108
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093    89 PALH---EFPRDIFSNEDRRQGAVVLHVLCAMYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFT 165
Cdd:TIGR00927  434 PDLHpkaEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFT 513

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093   166 SVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVALSSWCLLRDSIYYTLSVVALIVFIYDEKVSWWESLVLVL 245
Cdd:TIGR00927  514 SLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLL 593

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093   246 MYLIYIIIMKYNACIH----QCFERR-----------TKGA-------GNMVNGLAN-----NAEIDDSSNCDA------ 292
Cdd:TIGR00927  594 AYALYVFTMKWNKQIElwvkEQLSRRpvakvmalgdlSKGDvaeaehtGERTGEEGErpteaEGENGEESGGEAeqeget 673

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093   293 -TVVLLK---------------KANFHRKASVIMVDELLSAYPHQLSFSEAGLRimITSHFPPKTRLSMASRMLINERQ- 355
Cdd:TIGR00927  674 eTKGENEsegeipaerkgeqegEGEIEAKEADHKGETEAEEVEHEGETEAEGTE--DEGEIETGEEGEEVEDEGEGEAEg 751

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093   356 RLINSRAYTNGESEVAIKIPIKHTVENGTGPSSAPDRG-VNGTRRDDIVAEADNETENENEDENNENDEEEDEDDDEGPY 434
Cdd:TIGR00927  752 KHEVETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDGeMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDE 831

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093   435 T--------------------------------------------------------------PFDPPSGKLETVKWAFT 452
Cdd:TIGR00927  832 TgeqelnaenqgeakqdekgvdggggsdggdseeeeeeeeeeeeeeeeeeeeeeeeeeneeplSLEWPETRQKQAIYLFL 911

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093   453 WPLSFVLYFTVPNCNKPHWEKWFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVA 532
Cdd:TIGR00927  912 LPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVA 991

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093   533 RQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLaVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGCG 612
Cdd:TIGR00927  992 RKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSL-INGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFT 1070

                          650
                   ....*....|....*.
gi 686661093   613 CLFLYGVFLCFSIMTE 628
Cdd:TIGR00927 1071 MFLLYFVFLIISVMLE 1086
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
129-623 9.37e-34

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 130.64  E-value: 9.37e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093 129 DFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAGqvVALS 208
Cdd:COG0530    2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093 209 SWCLLRDSIYYTLSVVALIVFIYDEKVSWWESLVLVLMYLIYIIimkynacihqcferrtkgagnmvnglannaeiddss 288
Cdd:COG0530   80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLY------------------------------------ 123

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093 289 ncdatvvllkkanfhrkasvimvdellsayphqlsfseaglrimitshfppktrlsmasRMLINERQRlinsraytnges 368
Cdd:COG0530  124 -----------------------------------------------------------YLIRRARKE------------ 132

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093 369 evaikipikhtvengtgpssapdrgvngtRRDDIVAEadnetenenedennendeeededddegpytpfDPPSGKLETVK 448
Cdd:COG0530  133 -----------------------------PAWEEVEE--------------------------------ELEEKPKMSLW 151

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093 449 WAFTWplsfvlyftvpncnkphwekwfmvtFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMAS 528
Cdd:COG0530  152 KALLL-------------------------LVLGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATS 206

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093 529 LIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDYGSYIRLnsrgliySVGLLLASVFVTVFGvhLNKWQLDKK 608
Cdd:COG0530  207 IVAARKGEDDLAVGNIIGSNIFNILLVLGIGALITPIPVDPAVLSFD-------LPVMLAATLLLLGLL--RTGGRIGRW 277

                        490
                 ....*....|....*
gi 686661093 609 LGCGCLFLYGVFLCF 623
Cdd:COG0530  278 EGLLLLALYLAYLAL 292
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 112-254 3.97e-27

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 107.30  E-value: 3.97e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093  112 HVLCAMYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNIL 191
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 686661093  192 CIIGVCGLFAGQVVALS----SWCLLRDSIYYTLSVVALIVFIYDEKVSWWESLVLVLMYLIYIIIM 254
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLllklDLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQ 147
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 107-637 4.29e-16

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 82.12  E-value: 4.29e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093 107 GAVVLHVlCAMYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSvIGVFITK--GDVGVGTIVG 184
Cdd:PLN03151 139 GYAVLGV-WLVALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFAS-IAAFVGKdaGEVGLNSVLG 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093 185 SAVFNILCIIGVCGL-FAGQVVALSSWCLLRDSIYYTLSVVALIVFIYDEKVSWWESLVLVLMYLIYIIIMKYNAcIHQC 263
Cdd:PLN03151 217 GAVFVTCVVVGIVSLcVADKEVQIDKRCFIRDLCFFLFTLVSLLVILMVGKVTVGGAIAFVSIYVVYAFLVAANE-ILRK 295

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093 264 FERRTKgagnmvnglannaeiddssnCDATVVLLKKANFHRKASvimVDELLSAYPHQL-SFSEAGlrimitshfPPKTR 342
Cdd:PLN03151 296 HARRLK--------------------LDVVTPLLPVQGSIFSPS---VEEDESMYSPLLeSDTESD---------VPRLQ 343

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093 343 LSMASRMLinerqrlinsraytngESEVAIKipIKHTVENGTGPSSAPDRGVNgtrrdDIVAEADNETENENEDENNEND 422
Cdd:PLN03151 344 TSLPQWMW----------------ASNVAIY--SNHFAKGSVHDEERPPWGWT-----DEGAEVESSLFSCSKLFSLLEM 400

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093 423 EEEDEDDDEGPYT-------PFDPPSGKLETVKWAFTW-----------------------PLSFVLY-FTVPncNKPHW 471
Cdd:PLN03151 401 PLTIPRRLTIPIVeedrwskTYAVASASLAPVLLAFLWssqddvslqariaayfigvaigsTLGFLAYkYTEP--DRPPR 478

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093 472 E---KWFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGmGD---MAVSNSI 545
Cdd:PLN03151 479 RfliPWVLGGFIMSIVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNG-GDgvqIAMSGCY 557

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093 546 GSNVFDILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGCGCLFLYGVFLCFSI 625
Cdd:PLN03151 558 AGPMFNTLVGLGMSMLLGAWSKSPESYMLPEDSSLFYTMGFLVSGLIWALVVLPRNDMRPNKTLGVGLIALYLIFLTFRV 637

                        570
                 ....*....|..
gi 686661093 626 MTEFNVFTFVNL 637
Cdd:PLN03151 638 STAMGFIPWAGL 649
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 89-628 1.37e-108

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 352.38  E-value: 1.37e-108
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093    89 PALH---EFPRDIFSNEDRRQGAVVLHVLCAMYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFT 165
Cdd:TIGR00927  434 PDLHpkaEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFT 513

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093   166 SVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVALSSWCLLRDSIYYTLSVVALIVFIYDEKVSWWESLVLVL 245
Cdd:TIGR00927  514 SLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLL 593

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093   246 MYLIYIIIMKYNACIH----QCFERR-----------TKGA-------GNMVNGLAN-----NAEIDDSSNCDA------ 292
Cdd:TIGR00927  594 AYALYVFTMKWNKQIElwvkEQLSRRpvakvmalgdlSKGDvaeaehtGERTGEEGErpteaEGENGEESGGEAeqeget 673

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093   293 -TVVLLK---------------KANFHRKASVIMVDELLSAYPHQLSFSEAGLRimITSHFPPKTRLSMASRMLINERQ- 355
Cdd:TIGR00927  674 eTKGENEsegeipaerkgeqegEGEIEAKEADHKGETEAEEVEHEGETEAEGTE--DEGEIETGEEGEEVEDEGEGEAEg 751

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093   356 RLINSRAYTNGESEVAIKIPIKHTVENGTGPSSAPDRG-VNGTRRDDIVAEADNETENENEDENNENDEEEDEDDDEGPY 434
Cdd:TIGR00927  752 KHEVETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDGeMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDE 831

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093   435 T--------------------------------------------------------------PFDPPSGKLETVKWAFT 452
Cdd:TIGR00927  832 TgeqelnaenqgeakqdekgvdggggsdggdseeeeeeeeeeeeeeeeeeeeeeeeeeneeplSLEWPETRQKQAIYLFL 911

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093   453 WPLSFVLYFTVPNCNKPHWEKWFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVA 532
Cdd:TIGR00927  912 LPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVA 991

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093   533 RQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLaVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGCG 612
Cdd:TIGR00927  992 RKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSL-INGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFT 1070

                          650
                   ....*....|....*.
gi 686661093   613 CLFLYGVFLCFSIMTE 628
Cdd:TIGR00927 1071 MFLLYFVFLIISVMLE 1086
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 111-604 2.00e-42

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 155.17  E-value: 2.00e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093  111 LHVLCAMYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNI 190
Cdd:TIGR00367   1 LLLIGYLILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093  191 LCIIGVCGLFAGQVVAlsSWCLLRDSIYYTLSVVALIVFIYDEKVSWWESLVLVLMYLIYiiimkynacihqcferrtkg 270
Cdd:TIGR00367  81 LLILGLSAIFSPIIVD--KDWLRRDILFYLLVSILLLFFGLDGQISRIDGVVLLILYIVY-------------------- 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093  271 agnmvnglannaeiddssncdaTVVLLKKanfhrkasvimvdellsayphqlsfseaglrimitshfppktrlsmasrml 350
Cdd:TIGR00367 139 ----------------------LLFLVKN--------------------------------------------------- 145

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093  351 inerQRLINSRAYTNgesevaikipiKHTVENGTGPSSapdrgvngtrrddivaeadnetenenedennendeeededdd 430
Cdd:TIGR00367 146 ----ERWVKYDTYTE-----------ENLDENNRRPQI------------------------------------------ 168

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093  431 egpytpfdppsgkletvkwaftwPLSFVlyftvpncnkphwekWFMVTFAsstlWIAAFSYMMVWMVTIIGYTLGIPDVI 510
Cdd:TIGR00367 169 -----------------------FFSLV---------------LLIIGLI----GLVVGSRLLVDGAVKIAEILGISEKI 206

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093  511 MGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLas 590
Cdd:TIGR00367 207 IGLTLLAIGTSLPELVVSLAAARKGLGDIAVGNVIGSNIFNILVGLGVPSLFMPIPVEPLAYNLDAPVMVIVTLLLML-- 284

                         490
                  ....*....|....
gi 686661093  591 vfVTVFGVHLNKWQ 604
Cdd:TIGR00367 285 --FFKTSMKLGRWE 296
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
129-623 9.37e-34

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 130.64  E-value: 9.37e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093 129 DFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAGqvVALS 208
Cdd:COG0530    2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093 209 SWCLLRDSIYYTLSVVALIVFIYDEKVSWWESLVLVLMYLIYIIimkynacihqcferrtkgagnmvnglannaeiddss 288
Cdd:COG0530   80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLY------------------------------------ 123

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093 289 ncdatvvllkkanfhrkasvimvdellsayphqlsfseaglrimitshfppktrlsmasRMLINERQRlinsraytnges 368
Cdd:COG0530  124 -----------------------------------------------------------YLIRRARKE------------ 132

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093 369 evaikipikhtvengtgpssapdrgvngtRRDDIVAEadnetenenedennendeeededddegpytpfDPPSGKLETVK 448
Cdd:COG0530  133 -----------------------------PAWEEVEE--------------------------------ELEEKPKMSLW 151

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093 449 WAFTWplsfvlyftvpncnkphwekwfmvtFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMAS 528
Cdd:COG0530  152 KALLL-------------------------LVLGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATS 206

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093 529 LIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDYGSYIRLnsrgliySVGLLLASVFVTVFGvhLNKWQLDKK 608
Cdd:COG0530  207 IVAARKGEDDLAVGNIIGSNIFNILLVLGIGALITPIPVDPAVLSFD-------LPVMLAATLLLLGLL--RTGGRIGRW 277

                        490
                 ....*....|....*
gi 686661093 609 LGCGCLFLYGVFLCF 623
Cdd:COG0530  278 EGLLLLALYLAYLAL 292
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 112-254 3.97e-27

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 107.30  E-value: 3.97e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093  112 HVLCAMYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNIL 191
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 686661093  192 CIIGVCGLFAGQVVALS----SWCLLRDSIYYTLSVVALIVFIYDEKVSWWESLVLVLMYLIYIIIM 254
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLllklDLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQ 147
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 474-626 1.92e-26

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 105.38  E-value: 1.92e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093  474 WFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDIL 553
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 686661093  554 IGLGLPWALQTLAVDyGSYIRLNSRGLIYSVGLLLASVFVTVFgvhLNKWQLDKKLGCGCLFLYGVFLCFSIM 626
Cdd:pfam01699  81 LVLGLSALIGPVKVD-SLLLKLDLGVLLLVALLLLLLLLLLLL---PLFGRLSRFEGLVLLLLYIVYLVFQIV 149
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
88-254 2.62e-23

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 100.59  E-value: 2.62e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093  88 EPALHEFPRDIFSNEDRRQGAVVLHVLCAMymfyALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSV 167
Cdd:COG0530  132 EPAWEEVEEELEEKPKMSLWKALLLLVLGL----ALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSI 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093 168 IGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAGqvVALSSWCLLRDSIYYTLSVVALIVFIY-DEKVSWWESLVLVLM 246
Cdd:COG0530  208 VAARKGEDDLAVGNIIGSNIFNILLVLGIGALITP--IPVDPAVLSFDLPVMLAATLLLLGLLRtGGRIGRWEGLLLLAL 285


                 ....*...
gi 686661093 247 YLIYIIIM 254
Cdd:COG0530  286 YLAYLALL 293
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 107-637 4.29e-16

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 82.12  E-value: 4.29e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093 107 GAVVLHVlCAMYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSvIGVFITK--GDVGVGTIVG 184
Cdd:PLN03151 139 GYAVLGV-WLVALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFAS-IAAFVGKdaGEVGLNSVLG 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093 185 SAVFNILCIIGVCGL-FAGQVVALSSWCLLRDSIYYTLSVVALIVFIYDEKVSWWESLVLVLMYLIYIIIMKYNAcIHQC 263
Cdd:PLN03151 217 GAVFVTCVVVGIVSLcVADKEVQIDKRCFIRDLCFFLFTLVSLLVILMVGKVTVGGAIAFVSIYVVYAFLVAANE-ILRK 295

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093 264 FERRTKgagnmvnglannaeiddssnCDATVVLLKKANFHRKASvimVDELLSAYPHQL-SFSEAGlrimitshfPPKTR 342
Cdd:PLN03151 296 HARRLK--------------------LDVVTPLLPVQGSIFSPS---VEEDESMYSPLLeSDTESD---------VPRLQ 343

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093 343 LSMASRMLinerqrlinsraytngESEVAIKipIKHTVENGTGPSSAPDRGVNgtrrdDIVAEADNETENENEDENNEND 422
Cdd:PLN03151 344 TSLPQWMW----------------ASNVAIY--SNHFAKGSVHDEERPPWGWT-----DEGAEVESSLFSCSKLFSLLEM 400

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093 423 EEEDEDDDEGPYT-------PFDPPSGKLETVKWAFTW-----------------------PLSFVLY-FTVPncNKPHW 471
Cdd:PLN03151 401 PLTIPRRLTIPIVeedrwskTYAVASASLAPVLLAFLWssqddvslqariaayfigvaigsTLGFLAYkYTEP--DRPPR 478

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093 472 E---KWFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGmGD---MAVSNSI 545
Cdd:PLN03151 479 RfliPWVLGGFIMSIVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNG-GDgvqIAMSGCY 557

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093 546 GSNVFDILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGCGCLFLYGVFLCFSI 625
Cdd:PLN03151 558 AGPMFNTLVGLGMSMLLGAWSKSPESYMLPEDSSLFYTMGFLVSGLIWALVVLPRNDMRPNKTLGVGLIALYLIFLTFRV 637

                        570
                 ....*....|..
gi 686661093 626 MTEFNVFTFVNL 637
Cdd:PLN03151 638 STAMGFIPWAGL 649
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 95-314 5.13e-14

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 75.60  E-value: 5.13e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093   95 PRDIfSNEDRRQGAVVLHVLcAMYMFYALAIVCDDFFV----------------PSLEKICERLHL-SEDVAGATFMAAG 157
Cdd:TIGR00845  63 PQNP-SVGDKIARATVYFVA-MVYMFLGVSIIADRFMAsievitsqekeitikkPNGETTVTTVRIwNETVSNLTLMALG 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093  158 SSAPELFTSVIGVF---ITKGDVGVGTIVGSAVFNILCIIGVCGLF--AGQVVAL---------SSWcllrdSIY-YTLS 222
Cdd:TIGR00845 141 SSAPEILLSVIEVCghnFEAGDLGPSTIVGSAAFNMFIIIAICVYVipDGETRKIkhlrvffvtAAW-----SVFaYVWL 215

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093  223 VVALIVFIYDEkVSWWESLvLVLMYLIYIIIMKYNACIHQCFE-------RRTKGAGNMVNGLANNAEIDDSSNCDATVV 295
Cdd:TIGR00845 216 YLILAVFSPGV-VEVWEGL-LTFFFFPLCVVFAWVADRRLLFYkyvykryRAGKQRGMIIETEGDRPKSKTEIEMDGKMV 293

                         250
                  ....*....|....*....
gi 686661093  296 LLKKANFHRKASVIMVDEL 314
Cdd:TIGR00845 294 NSHVDNFLDGALVLEVKEF 312
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
504-628 3.98e-13

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 70.16  E-value: 3.98e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093 504 LGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDygsyirlnSRGLIYS 583
Cdd:COG0530   15 LGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRPLAVD--------RRVLRRD 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 686661093 584 VGLLLASVFVTVFGVHLNkwQLDKKLGCGCLFLYGVFLCFSIMTE 628
Cdd:COG0530   87 LPFLLLASLLLLALLLDG--TLSRIDGVILLLLYVLYLYYLIRRA 129
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 102-250 6.40e-13

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 70.05  E-value: 6.40e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093  102 EDRRQGAVVLHVLCAMYMFYALAIVCDdFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGT 181
Cdd:TIGR00367 161 ENNRRPQIFFSLVLLIIGLIGLVVGSR-LLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVGN 239

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 686661093  182 IVGSAVFNILCIIGVCGLFA-GQVVALSswcLLRD-SIYYTLSVVALIVFIYDEKVSWWESLVLVLMYLIY 250
Cdd:TIGR00367 240 VIGSNIFNILVGLGVPSLFMpIPVEPLA---YNLDaPVMVIVTLLLMLFFKTSMKLGRWEGILLLALYIAY 307
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 492-634 1.02e-12

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 69.67  E-value: 1.02e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093 492 MMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDYGS 571
Cdd:PRK10734 192 MVIDNATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALISPGEINPLA 271

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 686661093 572 YIRlnsrglIYSVgLLLASVFVTVFGvhlnkWQLDKKLG--CGCLFLYGVFLCFSIMTEFNVFTF 634
Cdd:PRK10734 272 FSR------DYWV-MLLVSVIFALLC-----WRRKRRIGrgAGALLLGGFIVWLAMLYWLSPILV 324
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 498-625 3.46e-12

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 67.73  E-value: 3.46e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093  498 TIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDYgSYIRLNS 577
Cdd:TIGR00367  26 VRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNILLILGLSAIFSPIIVDK-DWLRRDI 104

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 686661093  578 RGLIYSVGLLLasvFVTVFGvhlnkwQLDKKLGCGCLFLYGVFLCFSI 625
Cdd:TIGR00367 105 LFYLLVSILLL---FFGLDG------QISRIDGVVLLILYIVYLLFLV 143
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 458-595 6.14e-11

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 65.58  E-value: 6.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093  458 VLYFTVPNCNkpHWEKWfmVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMG 537
Cdd:TIGR00845 742 VLFAFVPPTE--YWGGW--ACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQY 817

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 686661093  538 -DMAVSNSIGSNVFDILIGLGLPWalqTLAVDY----GSYIRLNSRGLIYSVGLLLASVFVTV 595
Cdd:TIGR00845 818 aDASIGNVTGSNAVNVFLGIGVAW---SIAAIYhaanGTQFKVSPGTLAFSVTLFTIFAFICI 877
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 493-625 2.96e-10

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 61.97  E-value: 2.96e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093 493 MVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVdYGSY 572
Cdd:PRK10734  22 LVFAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNILLILGLAALIRPFTV-HSDV 100

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 686661093 573 IRLNsrgliysvglLLASVFVTVF-GVHLNKWQLDKKLGCGCLFLYGVFLCFSI 625
Cdd:PRK10734 101 LRRE----------LPLMLLVSVLaGSVLYDGQLSRSDGIFLLLLAVLWLLFIV 144
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 110-254 5.18e-07

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 51.96  E-value: 5.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093 110 VLHVLCAMYMFYALAIVCDDFFVPSLekicerlhlsedVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFN 189
Cdd:PRK10734  13 LLLVYGADRLVFAASILCRTFGIPPL------------IIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITN 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 686661093 190 ILCIIGVCGLFAGQVVALSswcLLRDSIYYTLSVVALI-VFIYDEKVSWWESLVLVLMYLIYIIIM 254
Cdd:PRK10734  81 ILLILGLAALIRPFTVHSD---VLRRELPLMLLVSVLAgSVLYDGQLSRSDGIFLLLLAVLWLLFI 143
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 144-221 5.66e-07

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 51.96  E-value: 5.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093 144 LSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGL-----FAGQVVALSSWCLLRDSIY 218
Cdd:PRK10734 206 ISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALispgeINPLAFSRDYWVMLLVSVI 285


                 ...
gi 686661093 219 YTL 221
Cdd:PRK10734 286 FAL 288
caca2 TIGR00846
calcium/proton exchanger; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the ...
 125-250 1.82e-03

calcium/proton exchanger; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is generated from the calcium ion/proton exchangers of the CacA family. [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273297 [Multi-domain]  Cd Length: 363  Bit Score: 40.90  E-value: 1.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 686661093  125 IVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIgvcglfagQV 204
Cdd:TIGR00846 232 ILLADYLVDTIDDAVDSWGLSVAFIGLILAPIVGNAAEHVTAVKAALKNKLDLALGVALGSALQIILFVV--------PL 303

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 686661093  205 VALSSWCLLRD---------SIYYTLSVVALIVFIYDEKVSWWESLVLVLMYLIY 250
Cdd:TIGR00846 304 VVLVAWMLGIPmdlnfgtfeTIVLALSLFLTTITLQDGRSNYLEGAVLLALYIII 358
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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