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Conserved domains on  [gi|17136204|ref|NP_476567|]
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Glycerol-3-phosphate dehydrogenase 1, isoform A [Drosophila melanogaster]

Protein Classification

glycerol-3-phosphate dehydrogenase family protein( domain architecture ID 11496765)

glycerol-3-phosphate dehydrogenase family protein is similar to human L-alpha-glycerol-3-phosphate dehydrogenase 1 (GPD1), which catalyzes the reversible biological conversion of dihydroxyacetone (DHAP) to glycerol-3-phosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 6-343 0e+00

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


:

Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 544.24  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204     6 NVCIVGSGNWGSAIAKIVGANAAALPE-FEERVTMFVYEELIDGKKLTEIINETHENVKYLKGHKLPPNVVAVPDLVEAA 84
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENARALPElFEESVRMWVFEEEIEGRNLTEIINTTHENVKYLPGIKLPANLVAVPDLVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204    85 KNADILIFVVPHQFIPNFCKQLLGKIKPNAIAISLIKGFDKAEGGgIDLISHIITRHLKIPCAVLMGANLANEVAEGNFC 164
Cdd:TIGR03376  81 KGADILVFVIPHQFLEGICKQLKGHVKPNARAISCIKGLEVSKDG-VKLLSDIIEEELGIPCGVLSGANLANEVAKEKFS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204   165 ETTIGCTD----KKYGKVLRDLFQANHFRVVVVDDADAVEVCGALKNIVACGAGFVDGLKLGDNTKAAVIRLGLMEMIRF 240
Cdd:TIGR03376 160 ETTVGYRDpadfDVDARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLEMIKF 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204   241 VDVFYPGSKLSTFFESCGVADLITTCYGGRNRRVSEAFVTSGKTIEELEKEMLNGQKLQGPPTAEEVNYMLKNKGLEDKF 320
Cdd:TIGR03376 240 ARMFFPTGEVTFTFESCGVADLITTCLGGRNFKVGRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNKNKDDEF 319

                         330       340
                  ....*....|....*....|...
gi 17136204   321 PLFTAIHKICTNQLKPNDLIDCI 343
Cdd:TIGR03376 320 PLFEAVYQILYEGLPPKKLPECL 342
 
Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 6-343 0e+00

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 544.24  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204     6 NVCIVGSGNWGSAIAKIVGANAAALPE-FEERVTMFVYEELIDGKKLTEIINETHENVKYLKGHKLPPNVVAVPDLVEAA 84
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENARALPElFEESVRMWVFEEEIEGRNLTEIINTTHENVKYLPGIKLPANLVAVPDLVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204    85 KNADILIFVVPHQFIPNFCKQLLGKIKPNAIAISLIKGFDKAEGGgIDLISHIITRHLKIPCAVLMGANLANEVAEGNFC 164
Cdd:TIGR03376  81 KGADILVFVIPHQFLEGICKQLKGHVKPNARAISCIKGLEVSKDG-VKLLSDIIEEELGIPCGVLSGANLANEVAKEKFS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204   165 ETTIGCTD----KKYGKVLRDLFQANHFRVVVVDDADAVEVCGALKNIVACGAGFVDGLKLGDNTKAAVIRLGLMEMIRF 240
Cdd:TIGR03376 160 ETTVGYRDpadfDVDARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLEMIKF 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204   241 VDVFYPGSKLSTFFESCGVADLITTCYGGRNRRVSEAFVTSGKTIEELEKEMLNGQKLQGPPTAEEVNYMLKNKGLEDKF 320
Cdd:TIGR03376 240 ARMFFPTGEVTFTFESCGVADLITTCLGGRNFKVGRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNKNKDDEF 319

                         330       340
                  ....*....|....*....|...
gi 17136204   321 PLFTAIHKICTNQLKPNDLIDCI 343
Cdd:TIGR03376 320 PLFEAVYQILYEGLPPKKLPECL 342
PTZ00345 PTZ00345
glycerol-3-phosphate dehydrogenase; Provisional
 7-341 4.95e-154

glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 240373 [Multi-domain]  Cd Length: 365  Bit Score: 437.14  E-value: 4.95e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204    7 VCIVGSGNWGSAIAKIVGANAAALPEFEERVTMFVYEELIDGKKLTEIINETHENVKYLKGHKLPPNVVAVPDLVEAAKN 86
Cdd:PTZ00345  14 VSVIGSGNWGSAISKVVGENTQRNYIFHNEVRMWVLEEIVEGEKLSDIINTKHENVKYLPGIKLPDNIVAVSDLKEAVED 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204   87 ADILIFVVPHQFIPNFCKQL--LGKIKPNAIAISLIKGFdKAEGGGIDLISHIITRHLKIPCAVLMGANLANEVAEGNFC 164
Cdd:PTZ00345  94 ADLLIFVIPHQFLESVLSQIkeNNNLKKHARAISLTKGI-IVENGKPVLCSDVIEEELGIPCCALSGANVANDVAREEFS 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204  165 ETTIGCTDKKYGKVLRDLFQANHFRVVVVDDADAVEVCGALKNIVACGAGFVDGLKLGDNTKAAVIRLGLMEMIRFVDVF 244
Cdd:PTZ00345 173 EATIGCEDKDDALIWQRLFDRPYFKINCVPDVIGVEVCGALKNIIALAAGFCDGLGLGTNTKSAIIRIGLEEMKLFGKIF 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204  245 YPGSKLSTFFESCGVADLITTCYGGRNRRVSEAFVTSG--KTIEELEKEMLNGQKLQGPPTAEEVNYMLKNKGLEDKFPL 322
Cdd:PTZ00345 253 FPNVMDETFFESCGLADLITTCLGGRNVRCAAEFAKRNgkKSWEEIEAELLNGQKLQGTVTLKEVYEVLESHDLKKEFPL 332

                        330
                 ....*....|....*....
gi 17136204  323 FTAIHKICTNQLKPNDLID 341
Cdd:PTZ00345 333 FTVTYKIAFEGADPSSLID 351
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 6-341 1.08e-80

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 248.80  E-value: 1.08e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204   6 NVCIVGSGNWGSAIAKIVGANAaalpefeERVTMFVY-EELIDGkklteiINETHENVKYLKGHKLPPNVVAVPDLVEAA 84
Cdd:COG0240   2 KIAVLGAGSWGTALAKVLARNG-------HEVTLWGRdPEVAEE------INETRENPRYLPGVKLPENLRATSDLEEAL 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204  85 KNADILIFVVPHQFIPNFCKQLLGKIKPNAIAISLIKGFdkaEGGGIDLISHIITRHL--KIPCAVLMGANLANEVAEGN 162
Cdd:COG0240  69 AGADLVLLAVPSQALREVLEQLAPLLPPGAPVVSATKGI---EPGTGLLMSEVIAEELpgALRIAVLSGPSFAEEVARGL 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204 163 FCETTIGCTDKKYGKVLRDLFQANHFRvvvvddadavevCGALKNIVACGAGFVDGLKLGDNTKAAVIRLGLMEMIRFVD 242
Cdd:COG0240 146 PTAVVVASEDEEVAERLQELLSTPYFRvytsddvigvelGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEMTRLGV 225

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204 243 VFypGSKLSTFFESCGVADLITTCYG--GRNRRVSEAFVtSGKTIEELEKEMlnGQKLQGPPTAEEVNYMLKNKGLEdkF 320
Cdd:COG0240 226 AL--GARPETFMGLAGLGDLVLTCTSdlSRNRRFGLALG-KGKSLEEALAEM--GMVAEGVYTAKAVYELAEKLGVE--M 298

                       330       340
                ....*....|....*....|.
gi 17136204 321 PLFTAIHKICTNQLKPNDLID 341
Cdd:COG0240 299 PITEAVYAVLYEGKSPREAVE 319
NAD_Gly3P_dh_N pfam01210
NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent ...
 7-175 4.20e-64

NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain.


Pssm-ID: 395967 [Multi-domain]  Cd Length: 158  Bit Score: 200.50  E-value: 4.20e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204     7 VCIVGSGNWGSAIAKIVGANAaalpefeERVTMFVYEElidgkKLTEIINETHENVKYLKGHKLPPNVVAVPDLVEAAKN 86
Cdd:pfam01210   2 IAVLGAGSWGTALAKVLADNG-------HEVRLWGRDE-----ELIEEINTTHENVRYLPGIKLPENLKATTDLAEALKG 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204    87 ADILIFVVPHQFIPNFCKQLLGKIKPNAIAISLIKGFdkaEGGGIDLISHIITRHLKI--PCAVLMGANLANEVAEGNFC 164
Cdd:pfam01210  70 ADIIVIVVPSQALREVLKQLKGLLKPDAILVSLSKGI---EPGTLKLLSEVIEEELGIqpPIAVLSGPSHAEEVAQGLPT 146

                         170
                  ....*....|.
gi 17136204   165 ETTIGCTDKKY 175
Cdd:pfam01210 147 ATVIASKDEEA 157
 
Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 6-343 0e+00

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 544.24  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204     6 NVCIVGSGNWGSAIAKIVGANAAALPE-FEERVTMFVYEELIDGKKLTEIINETHENVKYLKGHKLPPNVVAVPDLVEAA 84
Cdd:TIGR03376   1 RVAVVGSGNWGTAIAKIVAENARALPElFEESVRMWVFEEEIEGRNLTEIINTTHENVKYLPGIKLPANLVAVPDLVEAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204    85 KNADILIFVVPHQFIPNFCKQLLGKIKPNAIAISLIKGFDKAEGGgIDLISHIITRHLKIPCAVLMGANLANEVAEGNFC 164
Cdd:TIGR03376  81 KGADILVFVIPHQFLEGICKQLKGHVKPNARAISCIKGLEVSKDG-VKLLSDIIEEELGIPCGVLSGANLANEVAKEKFS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204   165 ETTIGCTD----KKYGKVLRDLFQANHFRVVVVDDADAVEVCGALKNIVACGAGFVDGLKLGDNTKAAVIRLGLMEMIRF 240
Cdd:TIGR03376 160 ETTVGYRDpadfDVDARVLKALFHRPYFRVNVVDDVAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLEMIKF 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204   241 VDVFYPGSKLSTFFESCGVADLITTCYGGRNRRVSEAFVTSGKTIEELEKEMLNGQKLQGPPTAEEVNYMLKNKGLEDKF 320
Cdd:TIGR03376 240 ARMFFPTGEVTFTFESCGVADLITTCLGGRNFKVGRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNKNKDDEF 319

                         330       340
                  ....*....|....*....|...
gi 17136204   321 PLFTAIHKICTNQLKPNDLIDCI 343
Cdd:TIGR03376 320 PLFEAVYQILYEGLPPKKLPECL 342
PTZ00345 PTZ00345
glycerol-3-phosphate dehydrogenase; Provisional
 7-341 4.95e-154

glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 240373 [Multi-domain]  Cd Length: 365  Bit Score: 437.14  E-value: 4.95e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204    7 VCIVGSGNWGSAIAKIVGANAAALPEFEERVTMFVYEELIDGKKLTEIINETHENVKYLKGHKLPPNVVAVPDLVEAAKN 86
Cdd:PTZ00345  14 VSVIGSGNWGSAISKVVGENTQRNYIFHNEVRMWVLEEIVEGEKLSDIINTKHENVKYLPGIKLPDNIVAVSDLKEAVED 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204   87 ADILIFVVPHQFIPNFCKQL--LGKIKPNAIAISLIKGFdKAEGGGIDLISHIITRHLKIPCAVLMGANLANEVAEGNFC 164
Cdd:PTZ00345  94 ADLLIFVIPHQFLESVLSQIkeNNNLKKHARAISLTKGI-IVENGKPVLCSDVIEEELGIPCCALSGANVANDVAREEFS 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204  165 ETTIGCTDKKYGKVLRDLFQANHFRVVVVDDADAVEVCGALKNIVACGAGFVDGLKLGDNTKAAVIRLGLMEMIRFVDVF 244
Cdd:PTZ00345 173 EATIGCEDKDDALIWQRLFDRPYFKINCVPDVIGVEVCGALKNIIALAAGFCDGLGLGTNTKSAIIRIGLEEMKLFGKIF 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204  245 YPGSKLSTFFESCGVADLITTCYGGRNRRVSEAFVTSG--KTIEELEKEMLNGQKLQGPPTAEEVNYMLKNKGLEDKFPL 322
Cdd:PTZ00345 253 FPNVMDETFFESCGLADLITTCLGGRNVRCAAEFAKRNgkKSWEEIEAELLNGQKLQGTVTLKEVYEVLESHDLKKEFPL 332

                        330
                 ....*....|....*....
gi 17136204  323 FTAIHKICTNQLKPNDLID 341
Cdd:PTZ00345 333 FTVTYKIAFEGADPSSLID 351
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 6-341 1.08e-80

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 248.80  E-value: 1.08e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204   6 NVCIVGSGNWGSAIAKIVGANAaalpefeERVTMFVY-EELIDGkklteiINETHENVKYLKGHKLPPNVVAVPDLVEAA 84
Cdd:COG0240   2 KIAVLGAGSWGTALAKVLARNG-------HEVTLWGRdPEVAEE------INETRENPRYLPGVKLPENLRATSDLEEAL 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204  85 KNADILIFVVPHQFIPNFCKQLLGKIKPNAIAISLIKGFdkaEGGGIDLISHIITRHL--KIPCAVLMGANLANEVAEGN 162
Cdd:COG0240  69 AGADLVLLAVPSQALREVLEQLAPLLPPGAPVVSATKGI---EPGTGLLMSEVIAEELpgALRIAVLSGPSFAEEVARGL 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204 163 FCETTIGCTDKKYGKVLRDLFQANHFRvvvvddadavevCGALKNIVACGAGFVDGLKLGDNTKAAVIRLGLMEMIRFVD 242
Cdd:COG0240 146 PTAVVVASEDEEVAERLQELLSTPYFRvytsddvigvelGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEMTRLGV 225

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204 243 VFypGSKLSTFFESCGVADLITTCYG--GRNRRVSEAFVtSGKTIEELEKEMlnGQKLQGPPTAEEVNYMLKNKGLEdkF 320
Cdd:COG0240 226 AL--GARPETFMGLAGLGDLVLTCTSdlSRNRRFGLALG-KGKSLEEALAEM--GMVAEGVYTAKAVYELAEKLGVE--M 298

                       330       340
                ....*....|....*....|.
gi 17136204 321 PLFTAIHKICTNQLKPNDLID 341
Cdd:COG0240 299 PITEAVYAVLYEGKSPREAVE 319
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
6-341 2.74e-67

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 214.55  E-value: 2.74e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204    6 NVCIVGSGNWGSAIAKIVGANAAalpefeeRVTMFVYEElidgkKLTEIINETHENVKYLKGHKLPPNVVAVPDLVEAAK 85
Cdd:PRK00094   3 KIAVLGAGSWGTALAIVLARNGH-------DVTLWARDP-----EQAAEINADRENPRYLPGIKLPDNLRATTDLAEALA 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204   86 NADILIFVVPHQFIPNFCKQLLGKIKPNAIAISLIKGFDKAEGggiDLISHIITRHL--KIPCAVLMGANLANEVAEGNF 163
Cdd:PRK00094  71 DADLILVAVPSQALREVLKQLKPLLPPDAPIVWATKGIEPGTG---KLLSEVLEEELpdLAPIAVLSGPSFAKEVARGLP 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204  164 CETTIGCTDKKYGKVLRDLFQANHFRVVVVDDADAVEVCGALKNIVACGAGFVDGLKLGDNTKAAVIRLGLMEMIRFVDV 243
Cdd:PRK00094 148 TAVVIASTDEELAERVQELFHSPYFRVYTNTDVIGVELGGALKNVIAIAAGIADGLGLGDNARAALITRGLAEITRLGVA 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204  244 FypGSKLSTFFESCGVADLITTCYG--GRNRRVSEAFVtSGKTIEELEKEMlnGQKLQGPPTAEEVNYMLKNKGLEdkFP 321
Cdd:PRK00094 228 L--GANPETFLGLAGLGDLVLTCTSplSRNRRFGLALG-QGKSLEEALAEI--GMVAEGVRTAKAVYELAKKLGVE--MP 300

                        330       340
                 ....*....|....*....|
gi 17136204  322 LFTAIHKICTNQLKPNDLID 341
Cdd:PRK00094 301 ITEAVYAVLYEGKDPREAVE 320
NAD_Gly3P_dh_N pfam01210
NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent ...
 7-175 4.20e-64

NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain.


Pssm-ID: 395967 [Multi-domain]  Cd Length: 158  Bit Score: 200.50  E-value: 4.20e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204     7 VCIVGSGNWGSAIAKIVGANAaalpefeERVTMFVYEElidgkKLTEIINETHENVKYLKGHKLPPNVVAVPDLVEAAKN 86
Cdd:pfam01210   2 IAVLGAGSWGTALAKVLADNG-------HEVRLWGRDE-----ELIEEINTTHENVRYLPGIKLPENLKATTDLAEALKG 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204    87 ADILIFVVPHQFIPNFCKQLLGKIKPNAIAISLIKGFdkaEGGGIDLISHIITRHLKI--PCAVLMGANLANEVAEGNFC 164
Cdd:pfam01210  70 ADIIVIVVPSQALREVLKQLKGLLKPDAILVSLSKGI---EPGTLKLLSEVIEEELGIqpPIAVLSGPSHAEEVAQGLPT 146

                         170
                  ....*....|.
gi 17136204   165 ETTIGCTDKKY 175
Cdd:pfam01210 147 ATVIASKDEEA 157
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 202-341 1.02e-60

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 191.45  E-value: 1.02e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204   202 CGALKNIVACGAGFVDGLKLGDNTKAAVIRLGLMEMIRFVDVFypGSKLSTFFESCGVADLITTCYGG--RNRRVSEAFV 279
Cdd:pfam07479   8 GGALKNVIAIAAGIADGLGLGDNAKAALITRGLAEMIRLGKAL--GAKPETFFGLAGLGDLIVTCTSGlsRNRRFGEALG 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17136204   280 TsGKTIEELEKEMlnGQKLQGPPTAEEVNYMLKNKGLEdkFPLFTAIHKICTNQLKPNDLID 341
Cdd:pfam07479  86 K-GKSLEEAEKEL--GQVAEGVYTAKAVYELAKKLGVE--MPIFEAVYRILYEGKSPEEALE 142
PRK12439 PRK12439
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 1-317 1.45e-42

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 171500 [Multi-domain]  Cd Length: 341  Bit Score: 150.71  E-value: 1.45e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204    1 MADKVNVCIVGSGNWGSAIAKIVGANAAALPEFEERVTmfvyeelidgkklTEIINETHENVKYL-KGHKLPPNVVAVPD 79
Cdd:PRK12439   4 AKREPKVVVLGGGSWGTTVASICARRGPTLQWVRSAET-------------ADDINDNHRNSRYLgNDVVLSDTLRATTD 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204   80 LVEAAKNADILIFVVPHQFIPNFCKQLLGKIKPNAIAISLIKGFDKAEGGGI-DLISHIITRHlkiPCAVLMGANLANEV 158
Cdd:PRK12439  71 FAEAANCADVVVMGVPSHGFRGVLTELAKELRPWVPVVSLVKGLEQGTNMRMsQIIEEVLPGH---PAGILAGPNIAREV 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204  159 AEGNFCETTIGCTDKKYGKVLRDLFQANHFRVVVVDDADAVEVCGALKNIVACGAGFVDGLKLGDNTKAAVIRLGLMEMI 238
Cdd:PRK12439 148 AEGYAAAAVLAMPDQHLATRLSPLFRTRRFRVYTTDDVVGVEMAGALKNVFAIAVGMGYSLGIGENTRAMVIARALREMT 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204  239 RFVDVFypGSKLSTFFESCGVADLITTCYG--GRNRRVSEAfVTSGKTIEELEKEMlnGQKLQGPPTAEEVNYMLKNKGL 316
Cdd:PRK12439 228 KLGVAM--GGNPETFAGLAGMGDLIVTCTSqrSRNRHVGEQ-LGAGKPIDEIIASM--NQVAEGVKAASVVMEFADEYGL 302


                 .
gi 17136204  317 E 317
Cdd:PRK12439 303 N 303
PRK14618 PRK14618
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 6-336 9.12e-38

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237770 [Multi-domain]  Cd Length: 328  Bit Score: 137.70  E-value: 9.12e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204    6 NVCIVGSGNWGSAIAKIVGANA------AALPEFEERVTmfvyeelidgkklteiinETHENVKYLKGHKLPPNVVAVPD 79
Cdd:PRK14618   6 RVAVLGAGAWGTALAVLAASKGvpvrlwARRPEFAAALA------------------AERENREYLPGVALPAELYPTAD 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204   80 LVEAAKNADILIFVVPHQFIPNFCKQLlgkikPNAIAI-SLIKGFdKAEGGGIDLISHIITRHLKIPCAVLMGANLANEV 158
Cdd:PRK14618  68 PEEALAGADFAVVAVPSKALRETLAGL-----PRALGYvSCAKGL-APDGGRLSELARVLEFLTQARVAVLSGPNHAEEI 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204  159 AEGNFCETTIGCTDKKYGKVLRDLFQANHFRVVVVDDADAVEVCGALKNIVACGAGFVDGLKLGDNTKAAVIRLGLMEMI 238
Cdd:PRK14618 142 ARFLPAATVVASPEPGLARRVQAAFSGPSFRVYTSRDRVGVELGGALKNVIALAAGMVDGLKLGDNAKAALITRGLREMV 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204  239 RFVDVFypGSKLSTFFESCGVADLITTCYG--GRNRRVSEAFVtSGKTIEELEKEmlnGQKLQGPPTAEEVNYMLKNKGL 316
Cdd:PRK14618 222 RFGVAL--GAEEATFYGLSGLGDLIATATSphSRNRAAGEAIV-RGVDREHLEAG---GKVVEGLYTVKALDAWAKAHGH 295

                        330       340
                 ....*....|....*....|
gi 17136204  317 EdkFPLFTAIHKICTNQLKP 336
Cdd:PRK14618 296 D--LPIVEAVARVARGGWDP 313
PRK14620 PRK14620
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 7-329 1.49e-22

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 173083 [Multi-domain]  Cd Length: 326  Bit Score: 96.44  E-value: 1.49e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204    7 VCIVGSGNWGSAIAKIVGANAAALPEFEERVTMFvyeelidgkkltEIINETHENVKYLKGHKLPPNVVAVPDLVEA-AK 85
Cdd:PRK14620   3 ISILGAGSFGTAIAIALSSKKISVNLWGRNHTTF------------ESINTKRKNLKYLPTCHLPDNISVKSAIDEVlSD 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204   86 NADILIFVVPHQFIPNFCKQLLGK-IKPNAIAISLIKGFDKAEgggIDLISHIITRHLKI-PCAVLMGANLANEVAEGNF 163
Cdd:PRK14620  71 NATCIILAVPTQQLRTICQQLQDChLKKNTPILICSKGIEKSS---LKFPSEIVNEILPNnPIAILSGPSFAKEIAEKLP 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204  164 CETTIGCTDKKYGKVLRDLFQANHFRVVVVDDADAVEVCGALKNIVACGAGFVDGLKLGDNTKAAVIRLGlMEMIRFVDV 243
Cdd:PRK14620 148 CSIVLAGQNETLGSSLISKLSNENLKIIYSQDIIGVQIGAALKNIIAIACGIVLGKNLGNNAHAAVITKG-MNEIKTLYS 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204  244 FYPGS-KLSTFFESCGVADLITTCYGGRNRRVSEAF-VTSGKTIEELEKEmlNGQKLQGPPTAEEVNYMLKNkgLEDKFP 321
Cdd:PRK14620 227 AKNGSiDLNTLIGPSCLGDLILTCTTLHSRNMSFGFkIGNGFNINQILSE--GKSVIEGFSTVKPLISLAKK--LNIELP 302


                 ....*...
gi 17136204  322 LFTAIHKI 329
Cdd:PRK14620 303 ICESIYNL 310
PRK14619 PRK14619
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 1-308 5.09e-22

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237771 [Multi-domain]  Cd Length: 308  Bit Score: 94.67  E-value: 5.09e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204    1 MADKVNVCIVGSGNWGSAIAKIVGANaaalpefeervtmfvyeelidgkklteiinethenvkylkGHKlppnvVAV--- 77
Cdd:PRK14619   1 TTQPKTIAILGAGAWGSTLAGLASAN----------------------------------------GHR-----VRVwsr 35

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204   78 ---PDLVEAAKNADILIFVVPHQFIPNFCKQLLG-KIKPNAIAISLIKGFDKAeggGIDLISHII-TRHLKIPCAVLMGA 152
Cdd:PRK14619  36 rsgLSLAAVLADADVIVSAVSMKGVRPVAEQVQAlNLPPETIIVTATKGLDPE---TTRTPSQIWqAAFPNHPVVVLSGP 112

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204  153 NLANEVAEGNFCETTIGCTDKKYGKVLRDLFQANHFRVVVVDDADAVEVCGALKNIVACGAGFVDGLKLGDNTKAAVIRL 232
Cdd:PRK14619 113 NLSKEIQQGLPAATVVASRDLAAAETVQQIFSSERFRVYTNSDPLGTELGGTLKNVIAIAAGVCDGLQLGTNAKAALVTR 192

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17136204  233 GLMEMIRFVDVFypGSKLSTFFESCGVADLITTCYG--GRNRRVSEAfVTSGKTIEE-LEkemlngqKLQGppTAEEVN 308
Cdd:PRK14619 193 ALPEMIRVGTHL--GAQTETFYGLSGLGDLLATCTSplSRNYQVGYG-LAQGKSLEQiLA-------ELEG--TAEGVN 259
ProC COG0345
Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; ...
 6-152 1.91e-06

Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Pyrroline-5-carboxylate reductase is part of the Pathway/BioSystem: Proline biosynthesis


Pssm-ID: 440114 [Multi-domain]  Cd Length: 267  Bit Score: 48.52  E-value: 1.91e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136204   6 NVCIVGSGNWGSAIAKivGANAAALPEfeERVTmfVYEelIDGKKLTEIINEThenvkylkghklppNVVAVPDLVEAAK 85
Cdd:COG0345   4 KIGFIGAGNMGSAIIK--GLLKSGVPP--EDII--VSD--RSPERLEALAERY--------------GVRVTTDNAEAAA 61

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17136204  86 NADILIFVVPHQFIPNFCKQLLGKIKPNAIAISLIKGFDkaegggIDLISHIITRHLKI-------PCAVLMGA 152
Cdd:COG0345  62 QADVVVLAVKPQDLAEVLEELAPLLDPDKLVISIAAGVT------LATLEEALGGGAPVvrampntPALVGEGV 129
GPD_NAD_C_bact pfam20618
Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent ...
 257-326 1.69e-05

Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent glycerol-3-phosphate dehydrogenase (GPD) from bacteria and archaea. GPD catalyzes the reversible reduction of dihydroxyacetone phosphate to glycerol-3-phosphate.


Pssm-ID: 466767 [Multi-domain]  Cd Length: 66  Bit Score: 42.10  E-value: 1.69e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17136204   257 CGVADLITTCYGG--RNRRVSEAfVTSGKTIEELEKEMLngqkLQGPPTAEEVNYML-KNKGLEdkFPLFTAI 326
Cdd:pfam20618   1 AGLGDLVLTCTSDlsRNRTFGLL-LGKGMTLAEAGNGQV----AEGVRTAKAVAAILaRAHNVE--MPILEAV 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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