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Conserved domains on  [gi|24639017|ref|NP_476756|]
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suppressor of white-apricot, isoform A [Drosophila melanogaster]

Protein Classification

DRY_EERY and SWAP domain-containing protein( domain architecture ID 10560971)

DRY_EERY and SWAP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DRY_EERY pfam09750
Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP ...
 60-180 2.15e-38

Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP (suppressor-of-white-apricot protein) proteins. This region contains two highly conserved motifs, viz: DRY and EERY, which appear to be the sites for alternative splicing of exons 2 and 3 of the SWAP mRNA. These proteins are thus thought to be involved in auto-regulation of pre-mRNA splicing. Most family members are associated with two Surp domains pfam01805 and an Arginine- serine-rich binding region towards the C-terminus.


:

Pssm-ID: 462881  Cd Length: 129  Bit Score: 139.37  E-value: 2.15e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639017    60 LLVFGYACKIFRDDEKAREMDHGKQLIPWMGDVNLKIDRYDVRGALCELAPHEAppgGYGNRLEYLSAEEQRAEQLCEEE 139
Cdd:pfam09750   1 LQVFGRRCKLFRDDAIAAAAESGKHLVPWQGDPDLLIDRFDVRALLDDIPEYEA---GRSARLSELTSEEEEEERECNYE 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 24639017   140 RYLFLYNNEEELRLRQEEdLKRLQQE------------TSGGCFSQVGFQYDG 180
Cdd:pfam09750  78 RYRDLIKNEFEGVSEEEE-LKRIYQEeqfgakrlsaakKSSGSYAAIGFSYDD 129
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 232-284 1.21e-15

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


:

Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 71.85  E-value: 1.21e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 24639017    232 HAIIEKTARFIATQGAQMEILIKAKQANNTQFDFLTQGGHLQPYYRHLLAAIK 284
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPYHAYYRKKLAEYR 53
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 481-527 4.36e-15

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


:

Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 70.31  E-value: 4.36e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 24639017    481 RHIIDKTATYVIKNGRQFEETLRTKSVD--RFSFLLPANEYYPYYLYKV 527
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNnpQFDFLKPNDPYHAYYRKKL 49
 
Name Accession Description Interval E-value
DRY_EERY pfam09750
Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP ...
 60-180 2.15e-38

Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP (suppressor-of-white-apricot protein) proteins. This region contains two highly conserved motifs, viz: DRY and EERY, which appear to be the sites for alternative splicing of exons 2 and 3 of the SWAP mRNA. These proteins are thus thought to be involved in auto-regulation of pre-mRNA splicing. Most family members are associated with two Surp domains pfam01805 and an Arginine- serine-rich binding region towards the C-terminus.


Pssm-ID: 462881  Cd Length: 129  Bit Score: 139.37  E-value: 2.15e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639017    60 LLVFGYACKIFRDDEKAREMDHGKQLIPWMGDVNLKIDRYDVRGALCELAPHEAppgGYGNRLEYLSAEEQRAEQLCEEE 139
Cdd:pfam09750   1 LQVFGRRCKLFRDDAIAAAAESGKHLVPWQGDPDLLIDRFDVRALLDDIPEYEA---GRSARLSELTSEEEEEERECNYE 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 24639017   140 RYLFLYNNEEELRLRQEEdLKRLQQE------------TSGGCFSQVGFQYDG 180
Cdd:pfam09750  78 RYRDLIKNEFEGVSEEEE-LKRIYQEeqfgakrlsaakKSSGSYAAIGFSYDD 129
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 232-284 1.21e-15

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 71.85  E-value: 1.21e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 24639017    232 HAIIEKTARFIATQGAQMEILIKAKQANNTQFDFLTQGGHLQPYYRHLLAAIK 284
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPYHAYYRKKLAEYR 53
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 233-283 2.78e-15

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 70.63  E-value: 2.78e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 24639017   233 AIIEKTARFIATQGAQMEILIKAKQANNTQFDFLTQGGH-LQPYYRHLLAAI 283
Cdd:pfam01805   1 DIIKKTAQFVARNGPEFEALLMEREERNPQFDFLFDPDDpLHAYYRWKLEEY 52
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 481-527 4.36e-15

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 70.31  E-value: 4.36e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 24639017    481 RHIIDKTATYVIKNGRQFEETLRTKSVD--RFSFLLPANEYYPYYLYKV 527
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNnpQFDFLKPNDPYHAYYRKKL 49
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 483-527 6.40e-12

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 61.00  E-value: 6.40e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 24639017   483 IIDKTATYVIKNGRQFEETLRTKSVD--RFSFLLPAN-EYYPYYLYKV 527
Cdd:pfam01805   2 IIKKTAQFVARNGPEFEALLMEREERnpQFDFLFDPDdPLHAYYRWKL 49
 
Name Accession Description Interval E-value
DRY_EERY pfam09750
Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP ...
 60-180 2.15e-38

Alternative splicing regulator; This entry represents the conserved N-terminal region of SWAP (suppressor-of-white-apricot protein) proteins. This region contains two highly conserved motifs, viz: DRY and EERY, which appear to be the sites for alternative splicing of exons 2 and 3 of the SWAP mRNA. These proteins are thus thought to be involved in auto-regulation of pre-mRNA splicing. Most family members are associated with two Surp domains pfam01805 and an Arginine- serine-rich binding region towards the C-terminus.


Pssm-ID: 462881  Cd Length: 129  Bit Score: 139.37  E-value: 2.15e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24639017    60 LLVFGYACKIFRDDEKAREMDHGKQLIPWMGDVNLKIDRYDVRGALCELAPHEAppgGYGNRLEYLSAEEQRAEQLCEEE 139
Cdd:pfam09750   1 LQVFGRRCKLFRDDAIAAAAESGKHLVPWQGDPDLLIDRFDVRALLDDIPEYEA---GRSARLSELTSEEEEEERECNYE 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 24639017   140 RYLFLYNNEEELRLRQEEdLKRLQQE------------TSGGCFSQVGFQYDG 180
Cdd:pfam09750  78 RYRDLIKNEFEGVSEEEE-LKRIYQEeqfgakrlsaakKSSGSYAAIGFSYDD 129
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 232-284 1.21e-15

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 71.85  E-value: 1.21e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 24639017    232 HAIIEKTARFIATQGAQMEILIKAKQANNTQFDFLTQGGHLQPYYRHLLAAIK 284
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNNPQFDFLKPNDPYHAYYRKKLAEYR 53
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 233-283 2.78e-15

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 70.63  E-value: 2.78e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 24639017   233 AIIEKTARFIATQGAQMEILIKAKQANNTQFDFLTQGGH-LQPYYRHLLAAI 283
Cdd:pfam01805   1 DIIKKTAQFVARNGPEFEALLMEREERNPQFDFLFDPDDpLHAYYRWKLEEY 52
SWAP smart00648
Suppressor-of-White-APricot splicing regulator; domain present in regulators which are ...
 481-527 4.36e-15

Suppressor-of-White-APricot splicing regulator; domain present in regulators which are responsible for pre-mRNA splicing processes


Pssm-ID: 197818 [Multi-domain]  Cd Length: 54  Bit Score: 70.31  E-value: 4.36e-15
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 24639017    481 RHIIDKTATYVIKNGRQFEETLRTKSVD--RFSFLLPANEYYPYYLYKV 527
Cdd:smart00648   1 LDIIDKTAQFVARNGPEFEAKLMERERNnpQFDFLKPNDPYHAYYRKKL 49
Surp pfam01805
Surp module; This domain is also known as the SWAP domain. SWAP stands for ...
 483-527 6.40e-12

Surp module; This domain is also known as the SWAP domain. SWAP stands for Suppressor-of-White-APricot. It has been suggested that these domains may be RNA binding.


Pssm-ID: 460339 [Multi-domain]  Cd Length: 52  Bit Score: 61.00  E-value: 6.40e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 24639017   483 IIDKTATYVIKNGRQFEETLRTKSVD--RFSFLLPAN-EYYPYYLYKV 527
Cdd:pfam01805   2 IIKKTAQFVARNGPEFEALLMEREERnpQFDFLFDPDdPLHAYYRWKL 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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