|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00108 |
PTZ00108 |
DNA topoisomerase 2-like protein; Provisional |
5-1378 |
0e+00 |
|
DNA topoisomerase 2-like protein; Provisional
Pssm-ID: 240271 [Multi-domain] Cd Length: 1388 Bit Score: 1679.82 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 5 NKALSIEQMYQKKSQLEHILLRPDSYIGSVEFTKELMWVYDNSQNRMVQKEISFVPGLYKIFDEILVNAADNKQRDKS-- 82
Cdd:PTZ00108 1 KKNKTVEERYQKKTQIEHILLRPDTYIGSIETQTEDMWVYDEEKNRMVYKTITYVPGLYKIFDEILVNAADNKARDKGgh 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 83 -MNTIKIDIDPERNMVSVWNNGQGIPVTMHKEQKMYVPTMIFGHLLTSSNYNDDEKKVTGGRNGYGAKLCNIFSTSFTVE 161
Cdd:PTZ00108 81 rMTYIKVTIDEENGEISVYNDGEGIPVQIHKEHKIYVPEMIFGHLLTSSNYDDTEKRVTGGRNGFGAKLTNIFSTKFTVE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 162 TATREYKKSFKQTWGNNMGKASDVQIKDFNG-TDYTRITFSPDLAKFKMDRLDEDIVALMSRRAYDVAASSKGVSVFLNG 240
Cdd:PTZ00108 161 CVDSKSGKKFKMTWTDNMSKKSEPRITSYDGkKDYTKVTFYPDYAKFGMTEFDDDMLRLLKKRVYDLAGCFGKLKVYLNG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 241 NKLGVRNFKDYIDLHIKNTDDDSGPPIKIVHEVANERWEVACCPSDRGFQQVSFVNSIATYKGGRHVDHVVDNLIKQLLE 320
Cdd:PTZ00108 241 ERIAIKSFKDYVDLYLPDGEEGKKPPYPFVYTSVNGRWEVVVSLSDGQFQQVSFVNSICTTKGGTHVNYILDQLISKLQE 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 321 VLKKKNKGGINIKPFQVRNHLWVFVNCLIENPTFDSQTKENMTLQQKGFGSKCTLSEKFINNMSKSGIVESVLAWAKFKA 400
Cdd:PTZ00108 321 KAKKKKKKGKEIKPNQIKNHLWVFVNCLIVNPSFDSQTKETLTTKPSKFGSTCELSEKLIKYVLKSPILENIVEWAQAKL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 401 QNDIAK-TGGRKSSKIKGIPKLEDANEAGGKNSIKCTLILTEGDSAKSLAVSGLGVIGRDLYGVFPLRGKLLNVREANFK 479
Cdd:PTZ00108 401 AAELNKkMKAGKKSRILGIPKLDDANDAGGKNSEECTLILTEGDSAKALALAGLSVVGRDYYGVFPLRGKLLNVRDASLK 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 480 QLSENAEINNLCKIIGLQYKKKYlteDDLKTLRYGKVMIMTDQDQDGSHIKGLLINFIHTNWPELLRLP-FLEEFITPIV 558
Cdd:PTZ00108 481 QLMNNKEIQNLFKILGLDIGKKY---EDPKGLRYGSLMIMTDQDHDGSHIKGLLINMIHHFWPSLLKNPgFLKEFITPIV 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 559 KATKK-NEELSFYSLPEFEEWKNdTANHHTYNIKYYKGLGTSTSKEAKEYFQDMDRHRILFKYDGSVDDESIVMAFSKKH 637
Cdd:PTZ00108 558 KATKKgNQVISFFTIPDFEKWKQ-TVGLKGWKIKYYKGLGTSTDKEGKEYFSNIDKHRIRFVYVDDSDDDSIDLAFSKKR 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 638 IESRKVWLTNHMDEVkrrkelglperYL-YTKgtKSITYADFINLELVLFSNADNERSIPSLVDGLKPGQRKVMFTCFKR 716
Cdd:PTZ00108 637 VEDRKEWITNYKGGT-----------YVdHSK--KKLTYSDFVNKELILFSIADNERSIPSLVDGLKPGQRKILFACFKR 703
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 717 NDKREVKVAQLSGSVAEMSAYHHGEVSLQMTIVNLAQNFVGANNINLLEPRGQFGTRLSGGKDCASARYIFTIMSPLTRL 796
Cdd:PTZ00108 704 NLKNEIKVAQLSGYVSEHSAYHHGEQSLQQTIVGMAQNFVGSNNINLLYPCGQFGSRLQGGKDHAAARYIFTKLSKITRY 783
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 797 IYHPLDDPLLDYQVDDGQKIEPLWYLPIIPMVLVNGAEGIGTGWSTKISNYNPREIMKNLRKMINGQEPSVMHPWYKNFL 876
Cdd:PTZ00108 784 IFPEEDDPILDYLEDDGQSVEPFYYVPIIPMVLVNGAEGIGTGFSTSIPNYNPLDIIDNLRRRLNGEEVRPLVPWYRGFK 863
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 877 GRMEYVSDGRYIQTGNIQILSGNRLEISELPVGVWTQNYKENvlepLSNGTEKVKGIISEYREYHTDTTVRFVISFAPGE 956
Cdd:PTZ00108 864 GTIERNPKGKFISKGIYEKVPDGTVEITELPIGKWTEDYKEF----LESETLKEKDVIVDYRDYSTANTVHFTVKLNDGV 939
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 957 FEriHAEEGGFYRVFKLTTTLSTNQMHAFDQNNCLRRFPTAIDILKEYYKLRREYYARRRDFLVGQLTAQADRLSDQARF 1036
Cdd:PTZ00108 940 LE--QWEEEGIEKVFKLKSTISTTNMVLFDENGKIKKYSDALDILKEFYLVRLDLYKKRKEYLLGKLERELARLSNKVRF 1017
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 1037 ILEKCEKKLVVENKQRKAMCDELLKRGYrpDPVKEWQrRIKMEDAEQADeedeeeeeaapsvSSKAKKEKEVDPEKAFKK 1116
Cdd:PTZ00108 1018 IKHVINGELVITNAKKKDLVKELKKLGY--VRFKDII-KKKSEKITAEE-------------EEGAEEDDEADDEDDEEE 1081
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 1117 LTDVKKFDYLLGMSMWMLTEEKKNELLKQRDTKLSELESLRKKTPEMLWLDDLDALESKLNEVEEKERAEEQGIN----- 1191
Cdd:PTZ00108 1082 LGAAVSYDYLLSMPIWSLTKEKVEKLNAELEKKEKELEKLKNTTPKDMWLEDLDKFEEALEEQEEVEEKEIAKEQrlksk 1161
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 1192 --LKTAKALKGQKSASAKGRKVKSMGGGAGAGDVFPDPDGEPVEFKITEEIIKKMAAAAKVAQAAKEPKKPKEPKEPKVK 1269
Cdd:PTZ00108 1162 tkGKASKLRKPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSVK 1241
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 1270 KEPKGKQIKAEPDASGDEVDEFDAMVEGGSKTSPKAKKAVVKKEPGEKKPRQKKENGGG-------------LKQSKIDF 1336
Cdd:PTZ00108 1242 RLKSKKNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPPPPSKRPDGESNGGSkpssptkkkvkkrLEGSLAAL 1321
|
1370 1380 1390 1400 1410
....*....|....*....|....*....|....*....|....*....|.
gi 17136538 1337 SKAK--------AKKSDDDVEEVTPRAE-RPGRRQASKKIDYSSLFSDEEE 1378
Cdd:PTZ00108 1322 KKKKksekktarKKKSKTRVKQASASQSsRLLRRPRKKKSDSSSEDDDDSE 1372
|
|
| PLN03128 |
PLN03128 |
DNA topoisomerase 2; Provisional |
9-1176 |
0e+00 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215593 [Multi-domain] Cd Length: 1135 Bit Score: 1612.08 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 9 SIEQMYQKKSQLEHILLRPDSYIGSVEFTKELMWVYDNSqnRMVQKEISFVPGLYKIFDEILVNAADNKQRDKSMNTIKI 88
Cdd:PLN03128 2 TIEETYQKKTQLEHILLRPDTYIGSTEKHTQTLWVYEGG--EMVNREVTYVPGLYKIFDEILVNAADNKQRDPSMDSLKV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 89 DIDPERNMVSVWNNGQGIPVTMHKEQKMYVPTMIFGHLLTSSNYNDDEKKVTGGRNGYGAKLCNIFSTSFTVETATREYK 168
Cdd:PLN03128 80 DIDVEQNTISVYNNGKGIPVEIHKEEGVYVPELIFGHLLTSSNFDDNEKKTTGGRNGYGAKLANIFSTEFTVETADGNRG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 169 KSFKQTWGNNMGKASDVQIKDFNGT-DYTRITFSPDLAKFKMDRLDEDIVALMSRRAYDVAASS-KGVSVFLNGNKLGVR 246
Cdd:PLN03128 160 KKYKQVFTNNMSVKSEPKITSCKASeNWTKITFKPDLAKFNMTRLDEDVVALMSKRVYDIAGCLgKKLKVELNGKKLPVK 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 247 NFKDYIDLHIKNTDDDSGPPiKIVHEVaNERWEVACCPSDRGFQQVSFVNSIATYKGGRHVDHVVDNLIKQLLEVLKKKN 326
Cdd:PLN03128 240 SFQDYVGLYLGPNSREDPLP-RIYEKV-NDRWEVCVSLSDGSFQQVSFVNSIATIKGGTHVDYVADQIVKHIQEKVKKKN 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 327 KGGINIKPFQVRNHLWVFVNCLIENPTFDSQTKENMTLQQKGFGSKCTLSEKFINNMSKSGIVESVLAWAKFKAQNDIAK 406
Cdd:PLN03128 318 KNATHVKPFQIKNHLWVFVNCLIENPTFDSQTKETLTTRPSSFGSKCELSEEFLKKVEKCGVVENILSWAQFKQQKELKK 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 407 TGGRKSSKIKGIPKLEDANEAGGKNSIKCTLILTEGDSAKSLAVSGLGVIGRDLYGVFPLRGKLLNVREANFKQLSENAE 486
Cdd:PLN03128 398 KDGAKRQRLTGIPKLDDANDAGGKKSKDCTLILTEGDSAKALAMSGLSVVGRDHYGVFPLRGKLLNVREASHKQIMKNAE 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 487 INNLCKIIGLQYKKKYlTEDDLKTLRYGKVMIMTDQDQDGSHIKGLLINFIHTNWPELLRLP-FLEEFITPIVKATKKNE 565
Cdd:PLN03128 478 ITNIKQILGLQFGKTY-DEENTKSLRYGHLMIMTDQDHDGSHIKGLIINFFHSFWPSLLKIPgFLVEFITPIVKATKGGK 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 566 ELSFYSLPEFEEWKNDT-ANHHTYNIKYYKGLGTSTSKEAKEYFQDMDRHRILFKYDGSVDDESIVMAFSKKHIESRKVW 644
Cdd:PLN03128 557 SLSFYTMPEYEAWKESLeGETKGWTIKYYKGLGTSTSEEAKEYFSNLDIHKKEFLWQSDEDGDLIDMAFSKKRVEDRKIW 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 645 LTNHMdevkrrkelglPERYLYTKGTKsITYADFINLELVLFSNADNERSIPSLVDGLKPGQRKVMFTCFKRNDKREVKV 724
Cdd:PLN03128 637 LNNYE-----------PGTFLDQTGNG-ISYSDFINKELILFSQADLARSIPSMVDGLKPSQRKVLFACFKRNLKSEIKV 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 725 AQLSGSVAEMSAYHHGEVSLQMTIVNLAQNFVGANNINLLEPRGQFGTRLSGGKDCASARYIFTIMSPLTRLIYHPLDDP 804
Cdd:PLN03128 705 AQLSGYVAEHSAYHHGEASLASTIIGMAQDFVGSNNINLLTPSGQFGTRLQGGKDAASARYIFTRLSPITRALFPKDDDV 784
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 805 LLDYQVDDGQKIEPLWYLPIIPMVLVNGAEGIGTGWSTKISNYNPREIMKNLRKMINGQEPSVMHPWYKNFLGRMEYVSD 884
Cdd:PLN03128 785 LLNYLNEDGQSIEPEWYCPIIPMVLVNGSEGIGTGWSTFIPNYNPRDIIANIRRLLRGEELEPMHPWYRGFKGTITEVST 864
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 885 ---GRYIQTGNIQILSGNRLEISELPVGVWTQNYKEnVLEPLSNGTEKVKGIISEYREYHTDTTVRFVISFAPGEFERih 961
Cdd:PLN03128 865 srsGSYTVTGIIEQIGDTTIRITELPVRKWTQDYKE-FLEALLTGTKKKEPEIKDFKENHTDTTVHFTVTLSEEKMAR-- 941
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 962 AEEGGFYRVFKLTTTLSTNQMHAFDQNNCLRRFPTAIDILKEYYKLRREYYARRRDFLVGQLTAQADRLSDQARFILEKC 1041
Cdd:PLN03128 942 ALAEGLEKKFKLSTTISTSNMHLFDKDGKIKKYDSPEDILEEFFHLRLDLYVKRKEVLLENLEYELKKLDNKARFILAVV 1021
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 1042 EKKLVVENKQRKAMCDELLKRGYRPDPVKewqrrikmedaeqadeedeeeeEAAPSVSSKAKKEKEVDPEKAFKKLTDVK 1121
Cdd:PLN03128 1022 KGEIVVNNRKRAELLAELEEKGFDKFPKT----------------------AKISETNVVGDRDGEASEEEEASDNELAK 1079
|
1130 1140 1150 1160 1170
....*....|....*....|....*....|....*....|....*....|....*
gi 17136538 1122 KFDYLLGMSMWMLTEEKKNELLKQRDTKLSELESLRKKTPEMLWLDDLDALESKL 1176
Cdd:PLN03128 1080 SYDYLLGMPISSLTLEKVDELRAERAKKETEVEELKKTTPEDLWRKDLDAFEEAL 1134
|
|
| PLN03237 |
PLN03237 |
DNA topoisomerase 2; Provisional |
9-1439 |
0e+00 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215641 [Multi-domain] Cd Length: 1465 Bit Score: 1428.10 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 9 SIEQMYQKKSQLEHILLRPDSYIGSVEFTKELMWVYDNsqNRMVQKEISFVPGLYKIFDEILVNAADNKQRDKSMNTIKI 88
Cdd:PLN03237 27 TIEEMYQKKSQLEHILLRPDTYIGSIEKHTQTLWVYET--DKMVQRSVTYVPGLYKIFDEILVNAADNKQRDPKMDSLRV 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 89 DIDPERNMVSVWNNGQGIPVTMHKEQKMYVPTMIFGHLLTSSNYNDDEKKVTGGRNGYGAKLCNIFSTSFTVETATREYK 168
Cdd:PLN03237 105 VIDVEQNLISVYNNGDGVPVEIHQEEGVYVPEMIFGHLLTSSNYDDNEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRQ 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 169 KSFKQTWGNNMGKASDVQIKDFNGTD-YTRITFSPDLAKFKMDRLDEDIVALMSRRAYDVAAS-SKGVSVFLNGNKLGVR 246
Cdd:PLN03237 185 KKYKQVFSNNMGKKSEPVITKCKKSEnWTKVTFKPDLAKFNMTHLEDDVVALMKKRVVDIAGClGKTVKVELNGKRIPVK 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 247 NFKDYIDLHIKNTDDDSGPPIKIVHEVANERWEVACCPSDRGFQQVSFVNSIATYKGGRHVDHVVDNLIKQLLEVLKKKN 326
Cdd:PLN03237 265 SFSDYVDLYLESANKSRPENLPRIYEKVNDRWEVCVSLSEGQFQQVSFVNSIATIKGGTHVDYVTNQIANHVMEAVNKKN 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 327 KGGiNIKPFQVRNHLWVFVNCLIENPTFDSQTKENMTLQQKGFGSKCTLSEKFINNMSKSGIVESVLAWAKFKAQNDIAK 406
Cdd:PLN03237 345 KNA-NIKAHNVKNHLWVFVNALIDNPAFDSQTKETLTLRQSSFGSKCELSEDFLKKVMKSGIVENLLSWADFKQSKELKK 423
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 407 TGGRKSSKIKGIPKLEDANEAGGKNSIKCTLILTEGDSAKSLAVSGLGVIGRDLYGVFPLRGKLLNVREANFKQLSENAE 486
Cdd:PLN03237 424 TDGAKTTRVTGIPKLEDANEAGGKNSEKCTLILTEGDSAKALAVAGLSVVGRNYYGVFPLRGKLLNVREASHKQIMNNAE 503
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 487 INNLCKIIGLQYKKKYlteDDLKTLRYGKVMIMTDQDQDGSHIKGLLINFIHTNWPELLRLP-FLEEFITPIVKATKKNE 565
Cdd:PLN03237 504 IENIKQILGLQHGKQY---ESVKSLRYGHLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKVPsFLVEFITPIVKATRRGK 580
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 566 E-LSFYSLPEFEEWKNDTANHHT-YNIKYYKGLGTSTSKEAKEYFQDMDRHRILFKYDGSVDDESIVMAFSKKHIESRKV 643
Cdd:PLN03237 581 KvLSFYSMPEYEEWKESLGGNATgWSIKYYKGLGTSTAKEGKEYFKNLGKHKKDFVWEDEQDGDAIELAFSKKKIEARKN 660
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 644 WLTNHMdevkrrkelglPERYLYTKGtKSITYADFINLELVLFSNADNERSIPSLVDGLKPGQRKVMFTCFKRNDKREVK 723
Cdd:PLN03237 661 WLRQYE-----------PGTHLDQTQ-KDVKYSDFVNKELILFSMADLQRSIPSMVDGLKPGQRKILFCSFKRNFVKEAK 728
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 724 VAQLSGSVAEMSAYHHGEVSLQMTIVNLAQNFVGANNINLLEPRGQFGTRLSGGKDCASARYIFTIMSPLTRLIYHPLDD 803
Cdd:PLN03237 729 VAQLSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRLQGGKDHASARYIFTRLSPITRFLFPKDDD 808
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 804 PLLDYQVDDGQKIEPLWYLPIIPMVLVNGAEGIGTGWSTKISNYNPREIMKNLRKMINGQEPSVMHPWYKNFLGRME--Y 881
Cdd:PLN03237 809 ILLDYLNEDGQSIEPTWYMPIIPTVLVNGAEGIGTGWSTFIPNYNPRDIVANIRRLLNGESMEPMHPWYRGFKGTIEktA 888
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 882 VSDG--RYIQTGNIQILSGNRLEISELPVGVWTQNYKEnVLEPLSNGTEKVKG-IISEYREYHTDTTVRFVISFAPGEFe 958
Cdd:PLN03237 889 SKEGgcTYTITGLYEEVDETTLRITELPIRRWTDDYKE-FLESLKTDNNKNKDpFIKDVKAYNDDTTVHFEVILSEENM- 966
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 959 rIHAEEGGFYRVFKLTTTLSTNQMHAFDQNNCLRRFPTAIDILKEYYKLRREYYARRRDFLVGQLTAQADRLSDQARFIL 1038
Cdd:PLN03237 967 -LAAKQEGLLKKFKLTTTISTSNMHLFDSKGVIKKYDTPEQILEEFFHLRLEYYEKRKEVLLKNLEFELLKLENKVRFIL 1045
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 1039 EKCEKKLVVENKQRKAMCDELLKRGYRPDPVKEwqrrikmedaeqadeedeeeEEAAPSVSSKAKKEKEVDPEKAFKKLT 1118
Cdd:PLN03237 1046 AVVDGEIIVNNRKKADLVEELRQKGFTPFPKKA--------------------KSVEAAVAGATDDAAEEEEEIDVSSSS 1105
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 1119 DVK--KFDYLLGMSMWMLTEEKKNELLKQRDTKLSELESLRKKTPEMLWLDDLDALESKLNEVEEKERAEEQ-------- 1188
Cdd:PLN03237 1106 GVRgsDYDYLLSMAIGTLTLEKVQELCADRDKLNIEVEDLKKTTPKSLWLKDLDALEKELDKLDKEDAKAEEareklqra 1185
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 1189 GINLKTAKALKGQKSASAKGRKVKSMGGGAGAGDVFPDPDGEPVE-FKITEEIIKKMAAAAKVAQAAKEPKKPKEPKEPK 1267
Cdd:PLN03237 1186 AARGESGAAKKVSRQAPKKPAPKKTTKKASESETTEETYGSSAMEtENVAEVVKPKGRAGAKKKAPAAAKEKEEEDEILD 1265
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 1268 VKKEPKGKQIKAEPDASGDEVDEFDAMVEGGSKTSPKAKKAVVKKEPGEKK-----------PRQKKENGGGLKQSKIDF 1336
Cdd:PLN03237 1266 LKDRLAAYNLDSAPAQSAKMEETVKAVPARRAAARKKPLASVSVISDSDDDdddfavevslaERLKKKGGRKPAAANKKA 1345
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 1337 SK----------AKAKKSDDDVEEVTPRAE----------RPGRRQASKKIDYSSL---------FSDEEEDGGNVGSDD 1387
Cdd:PLN03237 1346 AKppaaakkrgpATVQSGQKLLTEMLKPAEaigispekkvRKMRASPFNKKSGSVLgraatnketESSENVSGSSSSEKD 1425
|
1450 1460 1470 1480 1490
....*....|....*....|....*....|....*....|....*....|....*....
gi 17136538 1388 DGNASDDDSPKRPAKRG-------REDESSggakkkappkkrraviesddddieiDEDD 1439
Cdd:PLN03237 1426 EIDVSAKPRPQRANRKQttyvlsdSESESA-------------------------DDSD 1459
|
|
| TOP2c |
smart00433 |
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE |
61-650 |
0e+00 |
|
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE
Pssm-ID: 214659 [Multi-domain] Cd Length: 594 Bit Score: 812.94 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 61 GLYKIFDEILVNAADNKQRDKsMNTIKIDIDPErNMVSVWNNGQGIPVTMHKEQKMYVPTMIFGHLLTSSNYNDDEKKVT 140
Cdd:smart00433 1 GLHHLVDEIVDNAADEALAGY-MDTIKVTIDKD-NSISVEDNGRGIPVEIHPKEKKYAPEVIFTVLHAGGKFDDDAYKVS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 141 GGRNGYGAKLCNIFSTSFTVETATReyKKSFKQTWGNNMGKASDVQIKDFNGTDYTRITFSPDLAKFKMDRldEDIVALM 220
Cdd:smart00433 79 GGLHGVGASVVNALSTEFEVEVARD--GKEYKQSFSNNGKPLSEPKIIGDTKKDGTKVTFKPDLEIFGMTT--DDDFELL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 221 SRRAYDVAASSKGVSVFLNGNK-------LGVRNFKDYIDLHIKNTDDDSGPPIKIVHEVANERWEVACCPSDRG-FQQV 292
Cdd:smart00433 155 KRRLRELAFLNKGVKITLNDERsdeektfLFEGGIKDYVELLNKNKELLSPEPTYIEGEKDNIRVEVAFQYTDGYsENIV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 293 SFVNSIATYKGGRHVDHVVDNLIKQLLEVLKKKNKGG-INIKPFQVRNHLWVFVNCLIENPTFDSQTKENMTLQQKGFG- 370
Cdd:smart00433 235 SFVNNIATTEGGTHENGFKDALTRVINEYAKKKKKLKeKNIKGEDVREGLTAFISVKIPEPQFEGQTKEKLGTSEVRFGv 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 371 ----SKCTLSEKFINNMSKSGIVESVLAWAKFKAQNDIAKTGGRKS--SKIKGIPKLEDANEAGGKnsiKCTLILTEGDS 444
Cdd:smart00433 315 ekivSECLLSFLEENPVEASKIVEKVLLAAKARAAAKKARELTRKKklSSISLPGKLADASSAGPK---KCELFLVEGDS 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 445 AKSLAVSGLgviGRDLYGVFPLRGKLLNVREANFKQLSENAEINNLCKIIGLQYKKKYltedDLKTLRYGKVMIMTDQDQ 524
Cdd:smart00433 392 AGGSAKSGR---DRDFQAILPLRGKILNVEKASLDKILKNEEIQALITALGLGIGKDF----DIEKLRYGKIIIMTDADV 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 525 DGSHIKGLLINFIHTNWPELLRLPFLEEFITPIVKATKKN--EELSFYSLPEFEEWKNDTA-NHHTYNIKYYKGLGTSTS 601
Cdd:smart00433 465 DGSHIKGLLLTFFYRYMPPLIEAGFVYIAIPPLYKVTKGKkkYVYSFYSLDEYEKWLEKTEgNKSKYEIQRYKGLGEMNA 544
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|
gi 17136538 602 KEAKEYFQDMDRHRILFKY-DGSVDDESIVMAFSKKHIESRKVWLTNHMD 650
Cdd:smart00433 545 DQLWETTMDPERRTLLFVTlDDADEADLIFSALMGDKVEPRKEWIEENAP 594
|
|
| TOP4c |
smart00434 |
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC |
673-1167 |
0e+00 |
|
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
Pssm-ID: 214660 [Multi-domain] Cd Length: 444 Bit Score: 547.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 673 ITYADFINLELVLFSN-ADNERSIPSLVDGLKPGQRKVMFTCFKRNDKR-EVKVAQLSGSVAEMSAYH-HGEVSLQMTIV 749
Cdd:smart00434 1 IDIEDFINKEYLDYSMsVINGRAIPDVRDGLKPVQRRILYAMFKRGLTPdEPKVKSARGVGDVMGKYHpHGDSSLYDTIV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 750 NLAQNFVgaNNINLLEPRGQFGTRLsGGKDCASARYIFTIMSPLTRLIYHPLDDPLLDYQVD-DGQKIEPLWYLPIIPMV 828
Cdd:smart00434 81 RMAQDFS--NNYPLLDGQGNFGSRL-DGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNyDGQEIEPTVLPPIIPNL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 829 LVNGAEGIGTGWSTKISNYNPREIMKNLRKMINGQEPSV----MHPWYKNFLGRMEYVSDGRYIQTGNIQILSGNRLEIS 904
Cdd:smart00434 158 LVNGSSGIAVGMATNIPPHNLREVIDAVRRLIDNPDASIdelmMIPWGPDFPTGGEIVGPGKYVVRGKIEIEDDNTIVIT 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 905 ELPVGVWTQNYKENVLEPLSNGteKVKGIISEYREYHTDTTVRFVISFAPGEFEriHAEEGGFYRVFKLTTTLSTNQMHA 984
Cdd:smart00434 238 ELPYQVNTADLIEKIAELVKDK--KIEGIIDVRDESHDRTGVRIVIELKRGAMA--EVVLNGLYKLTKLQTTFSINMLAL 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 985 FDqNNCLRRFPTaIDILKEYYKLRREYYARRRDFLVGQLTaQADRLSDQARFILEKCEKKLVVENKQRKAMCDELLKRGY 1064
Cdd:smart00434 314 FD-NGRPKKYNL-KEILKEFLDHRLEVYTRRKEYLLGKLE-AERLHILEGLFIALSIIDEIIVLIRSSKDLAKEAKEKLM 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 1065 RPDpvkewqrrikmedaeqadeedeeeeeaapsvsskakkekevdpekafkkLTDVKKFDYLLGMSMWMLTEEKKNELLK 1144
Cdd:smart00434 391 ERF-------------------------------------------------ELSEIQADAILDMRLRRLTKLEVEKLEK 421
|
490 500
....*....|....*....|...
gi 17136538 1145 QRDTKLSELESLRKKTPEMLWLD 1167
Cdd:smart00434 422 ELKELEKEIEDLEKILASEEWLN 444
|
|
| TOP4c |
cd00187 |
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ... |
691-1172 |
5.13e-165 |
|
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.
Pssm-ID: 238111 [Multi-domain] Cd Length: 445 Bit Score: 502.87 E-value: 5.13e-165
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 691 NERSIPSLVDGLKPGQRKVMFTCFKRN---DKREVKVAQLSGSVAEMSaYHHGEVSLQMTIVNLAQNFvgANNINLLEPR 767
Cdd:cd00187 1 NGRALPDVRDGLKPVQRRILYAMFKRGltpDKPEKKVARLVGDVAGKY-HPHGDSSLYDTIVRMAQDF--SNNIPLLDPQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 768 GQFGTRlsGGKDCASARYIFTIMSPLTRLIYHPLDDPLLDYQVD-DGQKIEPLWYLPIIPMVLVNGAEGIGTGWSTKISN 846
Cdd:cd00187 78 GNFGSR--DGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNyDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 847 YNPREIMKNLRKMINGQEPS-------VMHPWYKNFlGRMEYVSD---------GRYIQTGNIQIL---SGNRLEISELP 907
Cdd:cd00187 156 HNLREVIDALRALIDNPEASidelmeiIKGPDFPTG-GIIEGRAGireayetgrGRYIIRGKYEIEddeGRNTIEITELP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 908 VGVWTQNYKENVLEPLSngtEKVKGIISEYREYHTDTTVRFVISFAPGEFEriHAEEGGFYRVFKLTTTLSTNqMHAFDQ 987
Cdd:cd00187 235 YQVNKAKLKEKIAELVK---DKKIEGISDVRDESDREGIRFVIELKRGAMA--EVVLNGLYKVTKLQTTFGIN-MVAFDP 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 988 NNCLRRFpTAIDILKEYYKLRREYYARRRDFLVGQLTAQADRLSDQARFILEKCE--KKLVVENKQRKAMCDELLKRGYR 1065
Cdd:cd00187 309 NGRPKKL-NLKEILQEFLDHRLEVYTRRKEYELGKAEARLHILEGLLKAILNIDEviNLIRSSDEAKKALIEELEKLGFS 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 1066 PDpvkewqrrikmedaeqadeedeeeeeaapsvsskakkekevdpekafkkltdvkKFDYLLGMSMWMLTEEKKNELLKQ 1145
Cdd:cd00187 388 EI------------------------------------------------------QADAILDMRLRRLTKLEREKLLKE 413
|
490 500 510
....*....|....*....|....*....|..
gi 17136538 1146 RDTKLSELESLRKKT-----PEMLWLDDLDAL 1172
Cdd:cd00187 414 LKELEAEIEDLEKILaseerPKDLWKEELDEF 445
|
|
| DNA_topoisoIV |
pfam00521 |
DNA gyrase/topoisomerase IV, subunit A; |
693-1170 |
3.60e-145 |
|
DNA gyrase/topoisomerase IV, subunit A;
Pssm-ID: 459843 [Multi-domain] Cd Length: 432 Bit Score: 450.08 E-value: 3.60e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 693 RSIPSLVDGLKPGQRKVMFTCFK--RNDKREVKVAQLSGSVaeMSAYH-HGEVSLQMTIVNLAQNFVGanNINLLEPRGQ 769
Cdd:pfam00521 1 RAIPDVRDGLKPVQRRILYAMFEllNLDKPYKKVARLVGDV--MGKYHpHGDASLYDAIVRMAQDFVG--NIPLLDGQGN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 770 FGTRLSGGKDcASARYIFTIMSPLTRLIYHPLDDPLLDYQVD-DGQKIEPLWYLPIIPMVLVNGAEGIGTGWSTKISNYN 848
Cdd:pfam00521 77 FGSRIDGDKD-AAMRYTETRLSKIARELFPDIDDDTVDYVPNyDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 849 PREIMKNLRKMINGQEPS-----VMHPWYKNFLGRMEY--------VSDGRYIQTGNIQILSGNRLEISELPVGVWTQNY 915
Cdd:pfam00521 156 LREIIDALIALLDGPEATllmkyIMGPDFPTGGGIIGKggikeaykTGRGKITVRAKVEIEDRKTIVITELPYGVWTSDL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 916 KENVLEPLSNGteKVKGiISEYREYhTDTTVRFVISFAPGEFERIhaEEGGFYRVFKLTTTLSTNQMHAFDQNnclRRFP 995
Cdd:pfam00521 236 IEKIEELVKNG--KIKG-ISDIRDE-SDRGVRIVIELKRGADPEV--VLNDLYKKTKLQTSFSTNNLVLFDGG---PKYL 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 996 TAIDILKEYYKLRREYYARRRDFLVGQLTAQADRLS------DQARFILEKCEKKLvVENKQRKAMCDELLKrgyrpdpv 1069
Cdd:pfam00521 307 GLKEILKEFLDHRLEVYERRKEYLLEKLEERLHILEgllialNNIDFVIEIIRGSI-DRKKAKKNLIEELSE-------- 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 1070 kewqrrikmedaeqadeedeeeeeaapsvsskakkekevdpekafkkltdvKKFDYLLGMSMWMLTEEKKNELLKQRDTK 1149
Cdd:pfam00521 378 ---------------------------------------------------IQADYLLDMRLRRLTKEEVDKLLEEIDEL 406
|
490 500
....*....|....*....|....*.
gi 17136538 1150 LSELESLRKKTPEM-----LWLDDLD 1170
Cdd:pfam00521 407 EKEIAELEKLLASEkklndLWIEELD 432
|
|
| HATPase_TopII-like |
cd16930 |
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the ... |
58-203 |
1.29e-95 |
|
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the histidine kinase-like ATPase (HATpase) domains of human topoisomerase IIA (TopIIA) and TopIIB, Saccharomyces cerevisae TOP2p, and related proteins. These proteins catalyze the passage of DNA double strands through a transient double-strand break in the presence of ATP.
Pssm-ID: 340407 [Multi-domain] Cd Length: 147 Bit Score: 303.49 E-value: 1.29e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 58 FVPGLYKIFDEILVNAADNKQRDKSMNTIKIDIDPERNMVSVWNNGQGIPVTMHKEQKMYVPTMIFGHLLTSSNYNDDEK 137
Cdd:cd16930 1 YVPGLYKIFDEILVNAADNKQRDKSMTCIKVTIDPENNEISVWNNGKGIPVVIHKEEKIYVPEMIFGHLLTSSNYDDDEK 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17136538 138 KVTGGRNGYGAKLCNIFSTSFTVETATREYKKSFKQTWGNNMGKASDVQIKDF-NGTDYTRITFSPD 203
Cdd:cd16930 81 KVTGGRNGYGAKLCNIFSTEFTVETADSESKKKFKQTWTNNMGKASEPKITPYeKGKDYTKVTFKPD 147
|
|
| TopoIIA_Trans_ScTopoIIA |
cd03481 |
TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the ... |
246-398 |
2.40e-87 |
|
TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded by a single gene. The type IIA enzymes are the predominant form of topoisomerase and are found in some bacteriophages, viruses and archaea, and in all bacteria and eukaryotes. All type IIA topoisomerases are related to each other at amino acid sequence level, though their oligomeric organization sometimes differs. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. TopoIIA enzymes also catenate/ decatenate duplex rings. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes.
Pssm-ID: 239563 [Multi-domain] Cd Length: 153 Bit Score: 280.71 E-value: 2.40e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 246 RNFKDYIDLHIKNTDDDSGPPIKIVHEVANERWEVACCPSDRGFQQVSFVNSIATYKGGRHVDHVVDNLIKQLLEVLKKK 325
Cdd:cd03481 1 KSFKDYVKLYLKDANKEDGPPPPVVYEPVNDRWEVAVALSDGQFQQVSFVNSIATTKGGTHVDYVADQIVKKLDEVVKKK 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17136538 326 NKGGINIKPFQVRNHLWVFVNCLIENPTFDSQTKENMTLQQKGFGSKCTLSEKFINNMSKSGIVESVLAWAKF 398
Cdd:cd03481 81 NKGGINVKPFQVKNHLWIFVNCLIENPSFDSQTKETLTTKPKSFGSKCELSEKFLKKAVKSGIVESVLSWAKF 153
|
|
| 39 |
PHA02569 |
DNA topoisomerase II large subunit; Provisional |
18-610 |
3.38e-87 |
|
DNA topoisomerase II large subunit; Provisional
Pssm-ID: 177398 [Multi-domain] Cd Length: 602 Bit Score: 297.05 E-value: 3.38e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 18 SQLEHILLRPDSYIGSVEFTKELMWVYDNSQnrmvqkEISFVPGLYKIFDEILVNAADNKQRDKSMNTIKIDIDPERNMV 97
Cdd:PHA02569 8 SDREHILKRPGMYIGSVAYEAHERFLFGKFT------QVEYVPGLVKIIDEIIDNSVDEAIRTNFKFANKIDVTIKNNQV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 98 SVWNNGQGIPVTMHKEQ---KMYVPTMIFGHLLTSSNYnDDEKKVTGGRNGYGAKLCNIFSTSFTVETATREYKKSFKQT 174
Cdd:PHA02569 82 TVSDNGRGIPQAMVTTPegeEIPGPVAAWTRTKAGSNF-DDTNRVTGGMNGVGSSLTNFFSVLFIGETCDGKNEVTVNCS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 175 wgNNMGKASDVQIKdfNGTDYTRITFSPDLAKFKMDRLDEDIVALMSRRAYDVAASSKGVSVFLNGNKLgVRNFKDYIdl 254
Cdd:PHA02569 161 --NGAENISWSTKP--GKGKGTSVTFIPDFSHFEVNGLDQQYLDIILDRLQTLAVVFPDIKFTFNGKKV-SGKFKKYA-- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 255 hiKNTDDDSgppikIVHEvaNERWEVACCPSDRGFQQVSFVNSIATYKGGRHVDHVVDNLIKQLLEVLKKKNKggINIKP 334
Cdd:PHA02569 234 --KQFGDDT-----IVQE--NDNVSIALAPSPDGFRQLSFVNGLHTKNGGHHVDCVMDDICEELIPMIKKKHK--IEVTK 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 335 FQVRNHLW--VFVNCLIeNPTFDSQTKENMTLQQKGFGSKCTLSEKFINN--MSKSG----IVESVLawAKFKAQNDIAK 406
Cdd:PHA02569 303 ARVKECLTivLFVRNMS-NPRFDSQTKERLTSPFGEIRNHIDLDYKKIAKqiLKTEAiimpIIEAAL--ARKLAAEKAAE 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 407 TGGRKSSKIKGIPKLEDANEAGgkNSIKCTLILTEGDSAKSLAVSglgVIGRDLYGVFPLRGKLLNVREANFKQLSENAE 486
Cdd:PHA02569 380 TKAAKKAKKAKVAKHIKANLIG--KDAETTLFLTEGDSAIGYLIE---VRDEELHGGYPLRGKVLNTWGMSYADILKNKE 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 487 INNLCKIIGLQykkkyLTEDDLKTlRYGKVMIMTDQDQDG-SHIKGLLINFIhTNWPELLRLPFLEEFITPIVKATKKNE 565
Cdd:PHA02569 455 LFDICAITGLV-----LGEKAENM-NYKNIAIMTDADVDGkGSIYPLLLAFF-SRWPELFEQGRIRFVKTPVIIAQVGKE 527
|
570 580 590 600
....*....|....*....|....*....|....*....|....*
gi 17136538 566 ELSFYSLPEFEEWKNDTAnhhTYNIKYYKGLGTSTSKEAKEYFQD 610
Cdd:PHA02569 528 TKWFYSLDEFEKAKDSLK---KWSIRYIKGLGSLRKSEYRRVINN 569
|
|
| 52 |
PHA02592 |
DNA topisomerase II medium subunit; Provisional |
671-1173 |
5.77e-76 |
|
DNA topisomerase II medium subunit; Provisional
Pssm-ID: 222896 [Multi-domain] Cd Length: 439 Bit Score: 259.60 E-value: 5.77e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 671 KSITYADFINLELVLFSNAD-NERSIPSLVDGLKPGQRKVMFTC--FKRNDKREV-KVAQLSGSVAEMSaYHHGEVSLQM 746
Cdd:PHA02592 4 KERSLKSIVNNEALEYAMYTvEERAIPNLIDGLKPVQRFVIHRAleYAKGNKEKFdKVAAIAGGVADLG-YHHGETSAQD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 747 TIVNLAQNFvgANNINLLEPRGQFGTRLsgGKDCASARYIFTIMSPLTRLIYHPLDdplLDYQVDDGQKIEPLWYLPIIP 826
Cdd:PHA02592 83 AGALMANTW--NNNIPLLDGQGNFGSRL--VQKAAAARYIFARVHDNFRKIYKDED---LAPVHEDPEHIPPAFYLPIIP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 827 MVLVNGAEGIGTGWSTKISNYNPREIMKNLRKMINGQEPSVMHPWYKNFLGRMEYVSDGRYIQTGNIQILSGNRLEISEL 906
Cdd:PHA02592 156 MVLLNGVSGIATGYATNILPHSPKSVIKAVLAALNGKDITEPKVQFPEFKGEVVEIEPGSYEIRGTYELNGKTKLHITEI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 907 PVGVWTQNYKEnVLEPLSNgtekvKGIISEYREYHTDtTVRFVISFAPGEFERIHAEEggFYRVFKLTTTLSTNqMHAFD 986
Cdd:PHA02592 236 PVKYDRETYVA-VLDPLEE-----KGKIVSYDDCTED-GFRFKVTLKREENEEATHEK--IMKDFGLIERVSQN-ITVIN 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 987 QNNCLRRFPTAIDILKEYYKLRREYYARRRDFLVGQLTAQADRLSDQARFILEKCEKKLVVENKQRKAMCDELlkrgyrp 1066
Cdd:PHA02592 306 ENGKLKVYENAEDLIRDFVEIRKTYVQKRIQYEIKETEEAFDLALAKAEFIKRVIAGEIVLQGKTRSELTEEL------- 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 1067 dpvkewqrrikmedaeqadeedeeeeeaapsvsskakKEKEVDPEKAfkkltdvkkfDYLLGMSMWMLTEEKKNELLKQR 1146
Cdd:PHA02592 379 -------------------------------------SDNKDFGEYA----------DKLVAMNIYSMTSDEREKLQKEA 411
|
490 500
....*....|....*....|....*..
gi 17136538 1147 DTKLSELESLRKKTPEMLWLDDLDALE 1173
Cdd:PHA02592 412 EELEKEHEYWKKTTAKKEYIKDLEELK 438
|
|
| TOPRIM_TopoIIA |
cd03365 |
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ... |
435-555 |
7.19e-75 |
|
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173785 [Multi-domain] Cd Length: 120 Bit Score: 243.75 E-value: 7.19e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 435 CTLILTEGDSAKSLAVSGLGVIGRDLYGVFPLRGKLLNVREANFKQLSENAEINNLCKIIGLQYKKKylTEDDLKTLRYG 514
Cdd:cd03365 1 CTLILTEGDSAKALAVAGLSVVGRDYYGVFPLRGKLLNVREASHKQIMENAEIQNIKKILGLQHGKS--DYESTKSLRYG 78
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 17136538 515 KVMIMTDQDQDGSHIKGLLINFIHTNWPELLRLP-FLEEFIT 555
Cdd:cd03365 79 RLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKIPgFLVEFIT 120
|
|
| TOPRIM_C |
pfam16898 |
C-terminal associated domain of TOPRIM; TOPRIM_C is found as the C-terminal extension of the ... |
553-691 |
6.06e-70 |
|
C-terminal associated domain of TOPRIM; TOPRIM_C is found as the C-terminal extension of the TOPRIM domain, pfam01751 in metazoa.
Pssm-ID: 465302 [Multi-domain] Cd Length: 127 Bit Score: 230.10 E-value: 6.06e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 553 FITPIVKATKKNEELSFYSLPEFEEWKNDTANHHTYNIKYYKGLGTSTSKEAKEYFQDMDRHRILFKYDGSVDDESIVMA 632
Cdd:pfam16898 1 FITPIVKVTKGKEVISFFSLPEYEEWKESTPNLKGWKIKYYKGLGTSTSEEAKEYFSNLDKHRKEFKYLGDDDDEAIDLA 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 17136538 633 FSKKHIESRKVWLTNHMdevkrrkelglPERYLYtKGTKSITYADFINLELVLFSNADN 691
Cdd:pfam16898 81 FSKKKADDRKEWLRNFN-----------PGTYLD-HSTKEISYSDFINKELILFSMADN 127
|
|
| TOPRIM_TopoIIA_like |
cd01030 |
TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain ... |
435-555 |
2.98e-58 |
|
TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173780 [Multi-domain] Cd Length: 115 Bit Score: 196.19 E-value: 2.98e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 435 CTLILTEGDSAKSLAVSGLGVIgrdLYGVFPLRGKLLNVREANFKQLSENAEINNLCKIIGLQYKKKYlteDDLKTLRYG 514
Cdd:cd01030 1 CELILVEGDSAGGSAKQGRDRV---FQAVFPLRGKILNVEKASLKKILKNEEIQNIIKALGLGIGKDD---FDLDKLRYG 74
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 17136538 515 KVMIMTDQDQDGSHIKGLLINFIHTNWPELLRLPFLEEFIT 555
Cdd:cd01030 75 KIIIMTDADVDGSHIRTLLLTFFYRFWPSLLENGFLYIAQT 115
|
|
| PRK05559 |
PRK05559 |
DNA topoisomerase IV subunit B; Reviewed |
20-652 |
1.49e-51 |
|
DNA topoisomerase IV subunit B; Reviewed
Pssm-ID: 235501 [Multi-domain] Cd Length: 631 Bit Score: 193.39 E-value: 1.49e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 20 LEHILLRPDSYIGSVEfTKelmwvydnsqnrmvqkeisfvpGLYKIFDEILVNAADnkqrDKSM---NTIKIDIDPErNM 96
Cdd:PRK05559 19 LEPVRKRPGMYIGSTD-TR----------------------GLHHLVQEVIDNSVD----EALAghgKRIEVTLHAD-GS 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 97 VSVWNNGQGIPVTMHKEQKMYVPTMIFGHLLTSSNYNDDEKKVTGGRNGYGAKLCNIFSTSFTVETAtRE---YKKSFKQ 173
Cdd:PRK05559 71 VSVRDNGRGIPVGIHPEEGKSGVEVILTKLHAGGKFSNKAYKFSGGLHGVGVSVVNALSSRLEVEVK-RDgkvYRQRFEG 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 174 twGNNMGKASDVQIKDFNGTDyTRITFSPD-----LAKFKMDRLDEdivalMSRR-AYDVaassKGVSVFLNgNKLGVRN 247
Cdd:PRK05559 150 --GDPVGPLEVVGTAGKRKTG-TRVRFWPDpkifdSPKFSPERLKE-----RLRSkAFLL----PGLTITLN-DERERQT 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 248 F------KDYIDLhiKNTDDDSGPPIKIVH---EVANERWEVACC--PSDRGFQQvSFVNSIATYKGGRHVdhvvdNLIK 316
Cdd:PRK05559 217 FhyenglKDYLAE--LNEGKETLPEEFVGSfegEAEGEAVEWALQwtDEGGENIE-SYVNLIPTPQGGTHE-----NGFR 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 317 Q-LLEVLK----KKN--KGGINIKPFQVRNHLWVFVNCLIENPTFDSQTKENM-TLQQKGFGSKcTLSEKFINNMSKSG- 387
Cdd:PRK05559 289 EgLLKAVRefaeKRNllPKGKKLEGEDVREGLAAVLSVKIPEPQFEGQTKEKLgSREARRFVSG-VVKDAFDLWLNQNPe 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 388 IVESVLAWAKFKAQ---NDIAKTGGRKSSKIKGIP-KLEDANeagGKNSIKCTLILTEGDSAkslavSGLGVIGRDLY-- 461
Cdd:PRK05559 368 LAEKLAEKAIKAAQarlRAAKKVKRKKKTSGPALPgKLADCT---SQDPERTELFLVEGDSA-----GGSAKQARDREfq 439
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 462 GVFPLRGKLLNVREANFKQLSENAEINNLCKIIGLQykkkYLTEDDLKTLRYGKVMIMTDQDQDGSHIKGLLINFIHTNW 541
Cdd:PRK05559 440 AILPLRGKILNTWEASLDDVLANEEIHDIIVAIGIG----PGDSFDLEDLRYGKIIIMTDADVDGAHIATLLLTFFYRHF 515
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 542 PELL---RLpfleeFI--TPIVKATKKNEELSFYSLPEFEEW-KNDTANHHTYNIKYYKGLGTSTSKEAKEyfQDMD-RH 614
Cdd:PRK05559 516 PPLVeagHV-----YIalPPLYRVDKGKKKIYALDEEEKEELlKKLGKKGGKPEIQRFKGLGEMNPDQLWE--TTMDpET 588
|
650 660 670 680
....*....|....*....|....*....|....*....|....*
gi 17136538 615 RILFKYdgSVDD----ESIV---MAfskKHIESRKVWLTNHMDEV 652
Cdd:PRK05559 589 RRLVRV--TIDDaeetEKLVdmlMG---KKAEPRREWIEENGDFA 628
|
|
| GyrB |
COG0187 |
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair]; |
20-653 |
2.66e-40 |
|
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];
Pssm-ID: 439957 [Multi-domain] Cd Length: 635 Bit Score: 159.42 E-value: 2.66e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 20 LEHILLRPDSYIGSvefTKE-----LMW-VYDNSqnrmvqkeisfvpglykiFDEILVNAADnkqrdksmnTIKIDIDPE 93
Cdd:COG0187 17 LEAVRKRPGMYIGS---TDErglhhLVWeIVDNS------------------IDEALAGYCD---------RIEVTLHAD 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 94 rNMVSVWNNGQGIPVTMHKEQKMYVPTMI---------FGhlltSSNYnddekKVTGGRNGYGAKLCNIFSTSFTVETAt 164
Cdd:COG0187 67 -GSVTVEDNGRGIPVDIHPKEGKSALEVVltvlhaggkFD----GGSY-----KVSGGLHGVGASVVNALSERLEVEVK- 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 165 RE---YKKSFKQtwgnnmGKA-SDVQ-IKDFNGTdYTRITFSPDL-----AKFKMDRLdedivalmSRRAYDVAasskgv 234
Cdd:COG0187 136 RDgkiYRQRFER------GKPvGPLEkIGKTDRT-GTTVRFKPDPeifetTEFDYETL--------AERLRELA------ 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 235 svFLNGnklGVR--------------NF------KDYIDLHIKNTDDDSGPPIKIVHEVANERWEVACCPSDRGFQQV-S 293
Cdd:COG0187 195 --FLNK---GLTitltdereeepkeeTFhyeggiKDFVEYLNEDKEPLHPEVIYFEGEKDGIEVEVALQWNDGYSENIhS 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 294 FVNSIATYKGGRHVD-------HVVDNLIKQLlEVLKKKNKggiNIKPFQVRNHLWVFVNCLIENPTFDSQTK------E 360
Cdd:COG0187 270 FVNNINTPEGGTHETgfrtaltRVINDYARKN-GLLKEKDK---NLTGDDVREGLTAVISVKLPEPQFEGQTKtklgnsE 345
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 361 NMTLQQKGFGSKctLSEKFINNMSKSG-IVESVLAWAKF----KAQNDIAKtggRKSS-KIKGIP-KLEDANEaggKNSI 433
Cdd:COG0187 346 ARGIVESVVSEK--LEHYLEENPAEAKkILEKAILAARAreaaRKARELVR---RKSAlESSGLPgKLADCSS---KDPE 417
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 434 KCTLILTEGDSA----KSlavsglgviGRD--LYGVFPLRGKLLNVREANFKQLSENAEINNLCKIIGLQYKKKYltedD 507
Cdd:COG0187 418 ESELFIVEGDSAggsaKQ---------GRDreFQAILPLRGKILNVEKARLDKILKNEEIRDLITALGTGIGDDF----D 484
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 508 LKTLRYGKVMIMTDQDQDGSHIKGLLINFIHTNWPELLRLPFLeeFI--TPIVKATKKNEELSFYSLPEFEEWKNDTANH 585
Cdd:COG0187 485 LEKLRYHKIIIMTDADVDGAHIRTLLLTFFYRYMRPLIEAGHV--YIaqPPLYRIKKGKKTYYAYSDAELDELLKELKGK 562
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17136538 586 HTYNIKYYKGLGTSTSKEAKEYfqDMD-RHRILFKydgsVDDESIVMA---FSK---KHIESRKVWLTNHMDEVK 653
Cdd:COG0187 563 KKVEIQRYKGLGEMNPEQLWET--TMDpETRTLLQ----VTIEDAAEAdeiFSLlmgDKVEPRREFIEENAKFVR 631
|
|
| gyrB |
PRK05644 |
DNA gyrase subunit B; Validated |
20-597 |
2.32e-30 |
|
DNA gyrase subunit B; Validated
Pssm-ID: 235542 [Multi-domain] Cd Length: 638 Bit Score: 129.06 E-value: 2.32e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 20 LEHILLRPDSYIGSvefTKE-----LMW-VYDNSqnrmvqkeisfvpglykiFDEILVNAADnkqrdksmnTIKIDIDPE 93
Cdd:PRK05644 19 LEAVRKRPGMYIGS---TGErglhhLVYeIVDNS------------------IDEALAGYCD---------HIEVTINED 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 94 rNMVSVWNNGQGIPVTMHKEQKM----YVPTMI-----FGhlltSSNYnddekKVTGGRNGYGAKLCNIFSTSFTVETaT 164
Cdd:PRK05644 69 -GSITVTDNGRGIPVDIHPKTGKpaveVVLTVLhaggkFG----GGGY-----KVSGGLHGVGVSVVNALSTWLEVEV-K 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 165 REYKKsFKQTWgnNMGK-ASDVQ-IKDFNGTDyTRITFSPDLAKFKMDRLDEDIVAlmsRRAYDVAASSKGVSVFL---- 238
Cdd:PRK05644 138 RDGKI-YYQEY--ERGVpVTPLEvIGETDETG-TTVTFKPDPEIFETTEFDYDTLA---TRLRELAFLNKGLKITLtder 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 239 NGNKL--------GVRNFKDYID-----LHIKntdddsgpPIKIVHEVANERWEVACCPSDrGFQQ--VSFVNSIATYKG 303
Cdd:PRK05644 211 EGEEKeetfhyegGIKEYVEYLNrnkepLHEE--------PIYFEGEKDGIEVEVAMQYND-GYSEniLSFANNINTHEG 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 304 GRHVDHVVDNLIKQLLEVLKKKN---KGGINIKPFQVRNHLWVFVNCLIENPTFDSQTK------ENMTLQQKGFGSKct 374
Cdd:PRK05644 282 GTHEEGFKTALTRVINDYARKNKllkEKDDNLTGEDVREGLTAVISVKHPEPQFEGQTKtklgnsEVRGIVDSVVSEA-- 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 375 LSEKFINN--MSKSgIVESVLAWAK-----FKAQnDIAKtggRKSS-KIKGIP-KLEDANEaggKNSIKCTLILTEGDSA 445
Cdd:PRK05644 360 LSEFLEENpnVAKK-IVEKAILAARareaaRKAR-ELTR---RKSAlESSSLPgKLADCSS---KDPEESELYIVEGDSA 431
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 446 KSLAVSGlgvigRDLY--GVFPLRGKLLNVREANFKQLSENAEINNLCKIIGLQYKKKYltedDLKTLRYGKVMIMTDQD 523
Cdd:PRK05644 432 GGSAKQG-----RDRRfqAILPLRGKILNVEKARLDKILKNEEIRALITALGTGIGDDF----DISKLRYHKIIIMTDAD 502
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17136538 524 QDGSHIKGLLINFIHTNWPELLRLPFLeeFIT--PIVKAtKKNEELSFYSLPEFEEWKNDTANHHT--YNIKYYKGLG 597
Cdd:PRK05644 503 VDGAHIRTLLLTFFYRYMRPLIEAGYV--YIAqpPLYKI-KKGGKEYAYSDEELDEILAELKLKGNpkYGIQRYKGLG 577
|
|
| DNA_gyraseB |
pfam00204 |
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal ... |
247-406 |
8.09e-30 |
|
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal S5 domain 2-like fold. This family is structurally related to PF01119.
Pssm-ID: 425522 [Multi-domain] Cd Length: 173 Bit Score: 116.95 E-value: 8.09e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 247 NFKDYIDLHIKNTDDDSGPPIKIVHEVANERWEVA---CCPSDRGFQQVSFVNSIATYKGGRHVDHVVDNLIKQLLEVLK 323
Cdd:pfam00204 1 GLKDFVEELNKDKKPLHKEIIYFEGESPDNRIEVEvalQWTDSYSENILSFVNNIATPEGGTHVDGFKSALTRTINEYAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 324 KKN---KGGINIKPFQVRNHLWVFVNCLIENPTFDSQTKENMTLQQKGFGSKCTLSEKFINNMSK-SGIVESVLAWAKFK 399
Cdd:pfam00204 81 KKGllkKKDEKITGEDIREGLTAVVSVKIPDPQFEGQTKEKLGNPEVKSAVEKIVSEKLEEFLEEnPEIAKKILEKALQA 160
|
....*..
gi 17136538 400 AQNDIAK 406
Cdd:pfam00204 161 AKARLAA 167
|
|
| PRK09631 |
PRK09631 |
DNA topoisomerase IV subunit A; Provisional |
692-933 |
2.12e-25 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 236598 [Multi-domain] Cd Length: 635 Bit Score: 113.26 E-value: 2.12e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 692 ERSIPSLVDGLKPGQRKVMFTCFKRNDKREVKVAQLSGsvaEMSAYH-HGEVSLQMTIVNLaqnfvgANNINLLEPRGQF 770
Cdd:PRK09631 22 DRAIPDVIDGLKPVQRRILHSLFEMHDGKFHKVANVVG---NTMKYHpHGDASIYEALVNL------ANKDLFIDKQGNF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 771 GTRLSGgkDCASA-RYIFTIMSPLTR-LIYHPlddPLLDYQVD-DGQKIEPLWYLPIIPMVLVNGAEGIGTGWSTKISNY 847
Cdd:PRK09631 93 GNLFTG--DPASAaRYIECRLTPLAKeVLYNK---EITEYEPSyDGRNNEPLCLPAKIPVILIQGAEGIAVGMATKILPH 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 848 NPREIMKNLRKMINGQEPSVmhpwYKNF-LGRMEYVSD-----GRYIQTGNIQILSGNRLEISELPVGVWTQNYKENVLE 921
Cdd:PRK09631 168 NFNEILQAVKSELLGESFAL----YPDFpTGGIVDVSEyadgnGKVLVRAKIETKDEKTIVIREIPFGTTTESLIASIEK 243
|
250
....*....|..
gi 17136538 922 PLSNGTEKVKGI 933
Cdd:PRK09631 244 AARKGKIKISSI 255
|
|
| gyrB |
PRK14939 |
DNA gyrase subunit B; Provisional |
84-544 |
6.43e-23 |
|
DNA gyrase subunit B; Provisional
Pssm-ID: 237860 [Multi-domain] Cd Length: 756 Bit Score: 105.95 E-value: 6.43e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 84 NTIKIDIDPErNMVSVWNNGQGIPVTMHKEQKMYVPTMIFGHLLTSSNYNDDEKKVTGGRNGYGAKLCNIFSTSF--TVE 161
Cdd:PRK14939 59 DDITVTIHAD-GSVSVSDNGRGIPTDIHPEEGVSAAEVIMTVLHAGGKFDQNSYKVSGGLHGVGVSVVNALSEWLelTIR 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 162 TATREYKKSFkqtwgnNMGKA-SDVQ-IKDFNGTDyTRITFSPDLAKFKMDRLDEDIVAlmsRRAYDVAASSKGVSVFL- 238
Cdd:PRK14939 138 RDGKIHEQEF------EHGVPvAPLKvVGETDKTG-TEVRFWPSPEIFENTEFDYDILA---KRLRELAFLNSGVRIRLk 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 239 ---NGNKL------GVRNFKDYIDlhiKNTDDDSGPPIKIVHEVANERWEVACCPSDrGFQQV--SFVNSIATYKGGRHV 307
Cdd:PRK14939 208 derDGKEEefhyegGIKAFVEYLN---RNKTPLHPNIFYFSGEKDGIGVEVALQWND-SYQENvlCFTNNIPQRDGGTHL 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 308 -------DHVVDNLIKQllEVLKKKNKggINIKPFQVRNHLWVFVNCLIENPTFDSQTK------------ENMTLQQkg 368
Cdd:PRK14939 284 agfraalTRTINNYIEK--EGLAKKAK--VSLTGDDAREGLTAVLSVKVPDPKFSSQTKdklvssevrpavESLVNEK-- 357
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 369 fgskctLSEKFINN-------MSKsgIVESVLA--WAKfKAQnDIAKtggRKSS-KIKGIP-KLEDANEaggKNSIKCTL 437
Cdd:PRK14939 358 ------LSEFLEENpneakiiVGK--IIDAARAreAAR-KAR-ELTR---RKGAlDIAGLPgKLADCQE---KDPALSEL 421
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 438 ILTEGDSA----KSlavsglgviGRD--LYGVFPLRGKLLNVREANF-KQLSeNAEINNLckI------IGlqykkkylT 504
Cdd:PRK14939 422 YLVEGDSAggsaKQ---------GRDrkFQAILPLKGKILNVEKARFdKMLS-SQEIGTL--ItalgcgIG--------R 481
|
490 500 510 520
....*....|....*....|....*....|....*....|.
gi 17136538 505 ED-DLKTLRYGKVMIMTDQDQDGSHIKGLLINFIHTNWPEL 544
Cdd:PRK14939 482 DEfNPDKLRYHKIIIMTDADVDGSHIRTLLLTFFYRQMPEL 522
|
|
| TOPRIM_TopoIIA_GyrB |
cd03366 |
TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain ... |
435-545 |
2.39e-21 |
|
TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. DNA gyrase is more effective at relaxing supercoils than decatentating DNA. DNA gyrase in addition inserts negative supercoils in the presence of ATP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173786 [Multi-domain] Cd Length: 114 Bit Score: 90.79 E-value: 2.39e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 435 CTLILTEGDSAKSLAVSGlgvigRDLY--GVFPLRGKLLNVREANFKQLSENAEINNLCKIIGLQYKKKYltedDLKTLR 512
Cdd:cd03366 1 SELYIVEGDSAGGSAKQG-----RDRRfqAILPLRGKILNVEKARLDKILKNEEIRALITALGTGIGEDF----DLEKLR 71
|
90 100 110
....*....|....*....|....*....|...
gi 17136538 513 YGKVMIMTDQDQDGSHIKGLLINFIHTNWPELL 545
Cdd:cd03366 72 YHKIIIMTDADVDGAHIRTLLLTFFFRYMRPLI 104
|
|
| PRK09630 |
PRK09630 |
DNA topoisomerase IV subunit A; Provisional |
692-943 |
4.79e-20 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 170022 Cd Length: 479 Bit Score: 95.35 E-value: 4.79e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 692 ERSIPSLVDGLKPGQRKVMFTCFKRNDKREVKVAQLSGSVaeMSAYHHGEVSLQMTIVNLaqnfvgANNINLLEPRGQFG 771
Cdd:PRK09630 22 ERAIPHILDGLKPVQRRLLWTLFRMDDGKMHKVANIAGRT--MALHPHGDAPIVEALVVL------ANKGYLIDTQGNFG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 772 TRLSGGKDcASARYIFTIMSPLTRLIYHPLDdpLLDYQVD-DGQKIEPLWYLPIIPMVLVNGAEGIGTGWSTKISNYNPR 850
Cdd:PRK09630 94 NPLTGDPH-AAARYIEARLSPLAKEVLFNTD--LMTFHDSyDGREKEPDILPAKLPLLLLHGVDGIAVGMTTKIFPHNFC 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 851 EIMKNLRKMINGQEPSVMHPWYKNflGRMEyVSD-----GRYIQTGNIQILSGNRLEISELPVGVWTQNYKENVLEPLSN 925
Cdd:PRK09630 171 ELLEAQIAILNDQPFTLLPDFPSG--GTMD-ASEyqdglGSITLRASIDIINDKTLLIKEICPSTTTETLIRSIENAAKR 247
|
250
....*....|....*...
gi 17136538 926 GTEKVKGIiseyREYHTD 943
Cdd:PRK09630 248 GIIKIDSI----QDFSTD 261
|
|
| PRK12758 |
PRK12758 |
DNA gyrase/topoisomerase IV subunit A; |
692-955 |
2.02e-18 |
|
DNA gyrase/topoisomerase IV subunit A;
Pssm-ID: 237192 [Multi-domain] Cd Length: 869 Bit Score: 91.60 E-value: 2.02e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 692 ERSIPSLVDGLKPGQRKVMFTCFKRNDKREVKVAQLSGSVaeMsAYH-HGEVSLQMTIVNLAQNFVganninLLEPRGQF 770
Cdd:PRK12758 41 ERAVPHIEDGLKPVQRRILHSMKEMDDGRYNKVANVVGHT--M-QYHpHGDASIGDALVQLGQKDL------LIDTQGNW 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 771 GTRLSgGKDCASARYIFTIMSPLT-RLIYHP-LDDPLLDYqvdDGQKIEPLwYLPI-IPMVLVNGAEGIGTGWSTKISNY 847
Cdd:PRK12758 112 GNILT-GDGAAAPRYIEARLSKFAlEVVFNPkTTEWQLSY---DGRKKEPV-TLPVkFPLLLAQGAEGIAVGLSTKILPH 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 848 NPREIMKNLRKMINGQEPSVmhpwYKNFL-GRMEYVSD-------GRYIQTGNIQILSGNRLEISELPVGVWTQNYKENV 919
Cdd:PRK12758 187 NFNELIDASIAYLKGKEFKL----YPDFPtGGIIDVSNyndgergGRVRVRAKIEKLDKKTLVITEIPYGTTTSSLIDSI 262
|
250 260 270
....*....|....*....|....*....|....*.
gi 17136538 920 LEPLSNGTEKVKGIiseyrEYHTDTTVRFVISFAPG 955
Cdd:PRK12758 263 LKANDKGKIKIKKV-----EDNTAADVEILVHLAPG 293
|
|
| gyrA |
TIGR01063 |
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ... |
693-852 |
9.08e-16 |
|
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273423 [Multi-domain] Cd Length: 800 Bit Score: 83.13 E-value: 9.08e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 693 RSIPSLVDGLKPGQRKVMFTCFK---RNDKREVKVAQLSGSVaeMSAYH-HGEVSLQMTIVNLAQNFvgANNINLLEPRG 768
Cdd:TIGR01063 25 RALPDVRDGLKPVHRRILYAMYElglTPDKPYKKSARIVGDV--MGKYHpHGDSAIYDTLVRMAQDF--SLRYPLVDGQG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 769 QFGTrlSGGKDCASARYIFTIMSPLTRLIYHPLDDPLLDYQVD-DGQKIEPLWYLPIIPMVLVNGAEGIGTGWSTKISNY 847
Cdd:TIGR01063 101 NFGS--IDGDPPAAMRYTEARLTKIAEELLRDIDKETVDFVPNyDGSEQEPTVLPSRFPNLLVNGSSGIAVGMATNIPPH 178
|
....*
gi 17136538 848 NPREI 852
Cdd:TIGR01063 179 NLGEI 183
|
|
| PTZ00109 |
PTZ00109 |
DNA gyrase subunit b; Provisional |
292-544 |
4.93e-14 |
|
DNA gyrase subunit b; Provisional
Pssm-ID: 240272 [Multi-domain] Cd Length: 903 Bit Score: 77.61 E-value: 4.93e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 292 VSFVNSIATyKGGRHVDHVVDNLIKQLLEVLKKKNKGGINIKPFQ---VRNHLWVFVNCLIENPTFDSQTKENMTLQQKG 368
Cdd:PTZ00109 425 KSFANNVST-TAGTHIDGFKYAITRCVNGNIKKNGYFKGNFVNIPgefIREGMTAIISVKLNGAEFDGQTKTKLGNHLLK 503
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 369 FGSKCTLSEKFINNMSK-----SGIVESVLAwakFKAQNDIAKTGG----RKSSKI--KGIP-KLEDANEaggkNSIKCT 436
Cdd:PTZ00109 504 TILESIVFEQLSEILEFepnllLAIYNKSLA---AKKAFEEAKAAKdlirQKNNQYysTILPgKLVDCIS----DDIERN 576
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 437 -LILTEGDSAkslAVSGLGVIGRDLYGVFPLRGKLLNVRE-ANFKQLSENAEINNLCKIIGLQYKKKYLTEDDLK----- 509
Cdd:PTZ00109 577 eLFIVEGESA---AGNAKQARNREFQAVLPLKGKILNIEKiKNNKKVFENSEIKLLITSIGLSVNPVTWRQYDLShgtka 653
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 17136538 510 -----------------------TLRYGKVMIMTDQDQDGSHIKGLLINFIHTNWPEL 544
Cdd:PTZ00109 654 skdesvqnnnstltkkknslfdtPLRYGKIILLTDADVDGEHLRILLLTLLYRFCPSL 711
|
|
| HATPase_GyrB-like |
cd16928 |
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes ... |
62-239 |
8.15e-14 |
|
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes histidine kinase-like ATPase domain of the B subunit of DNA gyrase. Bacterial DNA gyrase is a type II topoisomerase (type II as it transiently cleaves both strands of DNA) which catalyzes the introduction of negative supercoils into DNA, possibly by a mechanism in which one segment of the double-stranded DNA substrate is passed through a transient break in a second segment. It consists of GyrA and GyrB subunits in an A2B2 stoichiometry; GyrA subunits catalyze strand-breakage and reunion reactions, and GyrB subunits hydrolyze ATP. DNA gyrase is found in bacteria, plants and archaea, but as it is absent in humans it is a possible drug target for the treatment of bacterial and parasite infections.
Pssm-ID: 340405 [Multi-domain] Cd Length: 180 Bit Score: 71.03 E-value: 8.15e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 62 LYKIFDEILVNAADnkqrdKSM----NTIKIDIDPErNMVSVWNNGQGIPVTMHKEQKMYVPTMIFGHLLTSSNYNDDEK 137
Cdd:cd16928 1 LHHLVWEIVDNSID-----EALagyaTEIEVTLHED-NSITVEDNGRGIPVDIHPKTGKSAVEVVLTVLHAGGKFDGGSY 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 138 KVTGGRNGYGAKLCNIFSTSFTVETaTREyKKSFKQTWgNNMGKASDVQIKDFNGTDYTRITFSPDLAKFKMDRLDEDIV 217
Cdd:cd16928 75 KVSGGLHGVGVSVVNALSERLEVEV-KRD-GKIYRQEF-SRGGPLTPLEVIGETKKTGTTVRFWPDPEIFEKTEFDFDTL 151
|
170 180
....*....|....*....|..
gi 17136538 218 AlmsRRAYDVAASSKGVSVFLN 239
Cdd:cd16928 152 K---RRLRELAFLNKGLKIVLE 170
|
|
| TopoII_MutL_Trans |
cd00329 |
MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the ... |
248-360 |
1.68e-11 |
|
MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes. The GyrB dimerizes in response to ATP binding, and is homologous to the N-terminal half of eukaryotic Topo II and the ATPase fragment of MutL. Type II DNA topoisomerases catalyze the ATP-dependent transport of one DNA duplex through another, in the process generating transient double strand breaks via covalent attachments to both DNA strands at the 5' positions. Included in this group are proteins similar to human MLH1 and PMS2. MLH1 forms a heterodimer with PMS2 which functions in meiosis and in DNA mismatch repair (MMR). Cells lacking either hMLH1 or hPMS2 have a strong mutator phenotype and display microsatellite instability (MSI). Mutation in hMLH1 accounts for a large fraction of Lynch syndrome (HNPCC) families.
Pssm-ID: 238202 [Multi-domain] Cd Length: 107 Bit Score: 62.28 E-value: 1.68e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 248 FKDYIDLHIKNTDDDSgpPIKIVHEVANERWEVACCPSD----RGFQQVSFVNSIATYKGGRHVDHVVDNLIKQLlevlk 323
Cdd:cd00329 1 LKDRLAEILGDKVADK--LIYVEGESDGFRVEGAISYPDsgrsSKDRQFSFVNGRPVREGGTHVKAVREAYTRAL----- 73
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 17136538 324 kknkgginiKPFQVRNHLWVFVNCLIEN--PTFD-SQTKE 360
Cdd:cd00329 74 ---------NGDDVRRYPVAVLSLKIPPslVDVNvHPTKE 104
|
|
| PRK05561 |
PRK05561 |
DNA topoisomerase 4 subunit A; |
692-860 |
2.94e-10 |
|
DNA topoisomerase 4 subunit A;
Pssm-ID: 235503 [Multi-domain] Cd Length: 742 Bit Score: 65.13 E-value: 2.94e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 692 ERSIPSLVDGLKPGQRKVMFTCFK---RNDKREVKVAQLSGSVaeMSAYH-HGEVSLQMTIVNLAQNFvgANNINLLEPR 767
Cdd:PRK05561 33 DRALPDVRDGLKPVQRRILYAMSElglTPDAKFKKSARVVGDV--LGKYHpHGDSSIYDAMVRMAQDF--SYRYPLVDGQ 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 768 GQFGTRlsGGKDCASARYIFTIMSPLTRLIyhpLDDplLDYQ-VD-----DGQKIEPLWyLP-IIPMVLVNGAEGIGTGW 840
Cdd:PRK05561 109 GNFGSI--DGDPAAAMRYTEARLSPIAELL---LEE--IDEGtVDfvpnfDGTLKEPTV-LPaRFPNLLLNGATGIAVGM 180
|
170 180
....*....|....*....|
gi 17136538 841 STKISNYNPREIMKNLRKMI 860
Cdd:PRK05561 181 ATDIPPHNLREVIDAAIHLI 200
|
|
| PRK13979 |
PRK13979 |
DNA topoisomerase IV subunit A; Provisional |
692-937 |
1.94e-08 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 237576 [Multi-domain] Cd Length: 957 Bit Score: 59.35 E-value: 1.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 692 ERSIPSLVDGLKPGQRKVMFTCFKRN---DKREVKVAQLSGSVaeMSAYH-HGEVSLQMTIVNLAQNFvgANNINLLEPR 767
Cdd:PRK13979 36 DRALPDVRDGLKPVHRRILYGAYMLKafpDKPYYKSARIVGDI--LGKYHpHGDSSVYDAMVILAQDF--TTRMPLIDGH 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 768 GQFGTRlsGGKDCASARYIFTIMSPLTRLIYHPLDDPLLDyQVDD--GQKIEPLwYLPI-IPMVLVNGAEGIGTGWSTKI 844
Cdd:PRK13979 112 GNWGSI--DGDSAAAMRYTEARLTPIAMEMLRDIDKDVVN-MVDNysDSEKEPE-VLPArYPNLLVNGAFGIAVGLATNI 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 845 SNYNPREIMKNLRKMINGQEPSVMHpwyknflgRMEYVSdGRYIQTGNIQILSGNRLEISELPVGVWTQNYKENVlEPLS 924
Cdd:PRK13979 188 PPHNLKEVIDGTLAYIDNNEITTKE--------LMNYIK-GPDLPTGGILIGKKSLLSAYETGEGKVTLRAKTKI-EKLE 257
|
250
....*....|...
gi 17136538 925 NGteKVKGIISEY 937
Cdd:PRK13979 258 NG--RLGIVITEF 268
|
|
| GyrA |
COG0188 |
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair]; |
693-852 |
3.88e-08 |
|
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
Pssm-ID: 439958 [Multi-domain] Cd Length: 804 Bit Score: 58.13 E-value: 3.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 693 RSIPSLVDGLKPGQRKVMFTCFK---RNDKREVKVAQLSGSVaeMSAYH-HGEVSLQMTIVNLAQNFvgANNINLLEPRG 768
Cdd:COG0188 34 RALPDVRDGLKPVHRRILYAMHElglTPDKPYKKSARVVGDV--MGKYHpHGDSAVYDALVRMAQDF--SMRYPLVDGQG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 769 QFGTRlsGGkDCASA-RYIFTIMSPLTRLIyhpLDDplLDYQ-VD-----DGQKIEPLwYLP-IIPMVLVNGAEGIGTGW 840
Cdd:COG0188 110 NFGSI--DG-DPAAAmRYTEARLAKIAEEL---LAD--IDKDtVDfvpnyDGSEQEPT-VLPaRFPNLLVNGSSGIAVGM 180
|
170
....*....|..
gi 17136538 841 STKISNYNPREI 852
Cdd:COG0188 181 ATNIPPHNLGEV 192
|
|
| PRK05560 |
PRK05560 |
DNA gyrase subunit A; Validated |
693-852 |
4.53e-08 |
|
DNA gyrase subunit A; Validated
Pssm-ID: 235502 [Multi-domain] Cd Length: 805 Bit Score: 57.73 E-value: 4.53e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 693 RSIPSLVDGLKPGQRKVMFTCFK---RNDKREVKVAQLSGSVaeMSAYH-HGEVSLQMTIVNLAQNFvganniNLLEP-- 766
Cdd:PRK05560 29 RALPDVRDGLKPVHRRILYAMNElgnTPDKPYKKSARIVGDV--MGKYHpHGDSAVYDALVRMAQDF------SMRYPlv 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 767 RGQ--FGtrlSGGKDCASA-RYIFTIMSPLTRLIyhpLDDplLDYQ-VD-----DGQKIEPLwYLPI-IPMVLVNGAEGI 836
Cdd:PRK05560 101 DGQgnFG---SIDGDPAAAmRYTEARMSKIAHEL---LAD--IDKEtVDfvpnyDGSEQEPT-VLPArFPNLLVNGSSGI 171
|
170
....*....|....*.
gi 17136538 837 GTGWSTKISNYNPREI 852
Cdd:PRK05560 172 AVGMATNIPPHNLGEV 187
|
|
| Toprim |
pfam01751 |
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ... |
436-536 |
1.26e-06 |
|
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Pssm-ID: 396354 [Multi-domain] Cd Length: 93 Bit Score: 48.12 E-value: 1.26e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 436 TLILTEGDS-AKSLAvsglGVIGRDLYGVFPLRGKLLNVREanfkqlsenaeinnlckiiglQYKKKYLTEDDLKTLRYG 514
Cdd:pfam01751 1 ELIIVEGPSdAIALE----KALGGGFQAVVAVLGHLLSLEK---------------------GPKKKALKALKELALKAK 55
|
90 100
....*....|....*....|..
gi 17136538 515 KVMIMTDQDQDGSHIKGLLINF 536
Cdd:pfam01751 56 EVILATDPDREGEAIALKLLEL 77
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
61-158 |
4.51e-06 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 46.98 E-value: 4.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 61 GLYKIFDEILVNAADNKQrdkSMNTIKIDIDPE-RNMVSVWNNGQGIPVTMHKeqkmyvptMIFGHLLTSSnynddekKV 139
Cdd:pfam02518 5 RLRQVLSNLLDNALKHAA---KAGEITVTLSEGgELTLTVEDNGIGIPPEDLP--------RIFEPFSTAD-------KR 66
|
90
....*....|....*....
gi 17136538 140 TGGRNGYGAKLCNIFSTSF 158
Cdd:pfam02518 67 GGGGTGLGLSIVRKLVELL 85
|
|
| TOPRIM |
cd00188 |
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type ... |
435-549 |
5.22e-05 |
|
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from bacterial and archaea, and bacterial DNA repair proteins of the RecR/M family. This domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in nucleotide polymerization by primases and in strand joining in topoisomerases and, as a general acid in strand cleavage by topisomerases and nucleases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173773 [Multi-domain] Cd Length: 83 Bit Score: 43.18 E-value: 5.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 435 CTLILTEGDS-AKSLAVsglgvIGRDLYGVFPLRGKLLNVREANFKQLSENAEinnlckiiglqykkkylteddlktlry 513
Cdd:cd00188 1 KKLIIVEGPSdALALAQ-----AGGYGGAVVALGGHALNKTRELLKRLLGEAK--------------------------- 48
|
90 100 110
....*....|....*....|....*....|....*.
gi 17136538 514 gKVMIMTDQDQDGSHIKGLLINFIHTNWPELLRLPF 549
Cdd:cd00188 49 -EVIIATDADREGEAIALRLLELLKSLGKKVRRLLL 83
|
|
| HATPase_TopVIB-like |
cd16933 |
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family ... |
61-166 |
1.04e-04 |
|
Histidine kinase-like ATPase domain of type IIB topoisomerase, Topo VI, subunit B; This family includes the histidine kinase-like ATPase (HATPase) domain of the B subunit of topoisomerase VI (Topo VIB). Topo VI is a heterotetrameric complex composed of two TopVIA and two TopVIB subunits and is categorized as a type II B DNA topoisomerase. It is found in archaea and also in plants. Type II enzymes cleave both strands of a DNA duplex and pass a second duplex through the resulting break in an ATP-dependent mechanism. DNA cleavage by Topo VI generates two-nucleotide 5'-protruding ends.
Pssm-ID: 340410 [Multi-domain] Cd Length: 203 Bit Score: 45.03 E-value: 1.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 61 GLYKIFDEILVNAADNKQRDKSMNTIKIDI---DPERNMVSVWNNGQGIPVTmhkeqkmYVPtMIFGHLLTSSNYNddeK 137
Cdd:cd16933 19 SLYTTVRELVENSLDATEEAGILPDIKVEIeeiGKDHYKVIVEDNGPGIPEE-------QIP-KVFGKVLYGSKYH---N 87
|
90 100 110
....*....|....*....|....*....|....
gi 17136538 138 KVTGGRNGYGAKLCNIFSTSFT-----VETATRE 166
Cdd:cd16933 88 KQSRGQQGLGISAAVLYSQMTTgkpveIISSTKD 121
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
61-161 |
3.59e-04 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 41.48 E-value: 3.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136538 61 GLYKIFDEILVNAADNKQRDKSMnTIKIDIDPERNMVSVWNNGQGIPVTMHKEqkmyvptmIFGhlltsSNYNDDEKKVT 140
Cdd:smart00387 5 RLRQVLSNLLDNAIKYTPEGGRI-TVTLERDGDHVEITVEDNGPGIPPEDLEK--------IFE-----PFFRTDKRSRK 70
|
90 100
....*....|....*....|.
gi 17136538 141 GGRNGYGAKLCNIFSTSFTVE 161
Cdd:smart00387 71 IGGTGLGLSIVKKLVELHGGE 91
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