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Conserved domains on  [gi|17136772|ref|NP_476896|]
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male-specific lethal 1, isoform A [Drosophila melanogaster]

Protein Classification

MSL1 family protein( domain architecture ID 10633776)

MSL1 (male-specific lethal 1) family protein similar to vertebrate KAT8 regulatory NSL complex subunit 1 that as part of the NSL complex, is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PEHE pfam15275
PEHE domain; This domain was first identified in drosophila MSL1 (male-specific lethal 1). In ...
 866-983 8.85e-21

PEHE domain; This domain was first identified in drosophila MSL1 (male-specific lethal 1). In drosophila it binds to the histone acetyltransferase males-absent on the first protein (MOF) and to protein male-specific lethal-3 (MSL3).


:

Pssm-ID: 464607  Cd Length: 128  Bit Score: 89.08  E-value: 8.85e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136772    866 LEIPKWRDV---PVPPSSDKID-TELLSDATFERRHQKYVkdEVDRKCRDARYMKEQIRLEQLRMRR-NQDEVLVALDPL 940
Cdd:pfam15275    1 ILTPSWRVVdlnPLEDSEEDEDeIEDLSDEVFSKRHQKYE--EKERKRWDLWRIREQRRRESLRSRSyPSRNTPVPLGPQ 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 17136772    941 RASTFYPLPEDIEAiQFVNEVTVQAfgENVVNMEARDD----------FGVPW 983
Cdd:pfam15275   79 PSSPFYPSPEDIED-QSVLEVPVQA--SPLPPLSPETSsllseevqewFSLPW 128
PspC_subgroup_1 super family cl41462
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 447-583 4.71e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


The actual alignment was detected with superfamily member NF033838:

Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 44.23  E-value: 4.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136772   447 IRKEGNQNRITEKLLQLKPEPMVDALEAPILPKWVAFKKKDKE--HESVPESPEV---PKQQPHQEdaivdhNAIKNQLE 521
Cdd:NF033838  358 VKEEAKEPRNEEKIKQAKAKVESKKAEATRLEKIKTDRKKAEEeaKRKAAEEDKVkekPAEQPQPA------PAPQPEKP 431

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17136772   522 VPKPDlKPKDQPKDEQRQDGQldvrvePQEDVRKVQKETLKRQPEDAPKHLPKAVAPKVTKT 583
Cdd:NF033838  432 APKPE-KPAEQPKAEKPADQQ------AEEDYARRSEEEYNRLTQQQPPKTEKPAQPSTPKT 486
 
Name Accession Description Interval E-value
PEHE pfam15275
PEHE domain; This domain was first identified in drosophila MSL1 (male-specific lethal 1). In ...
 866-983 8.85e-21

PEHE domain; This domain was first identified in drosophila MSL1 (male-specific lethal 1). In drosophila it binds to the histone acetyltransferase males-absent on the first protein (MOF) and to protein male-specific lethal-3 (MSL3).


Pssm-ID: 464607  Cd Length: 128  Bit Score: 89.08  E-value: 8.85e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136772    866 LEIPKWRDV---PVPPSSDKID-TELLSDATFERRHQKYVkdEVDRKCRDARYMKEQIRLEQLRMRR-NQDEVLVALDPL 940
Cdd:pfam15275    1 ILTPSWRVVdlnPLEDSEEDEDeIEDLSDEVFSKRHQKYE--EKERKRWDLWRIREQRRRESLRSRSyPSRNTPVPLGPQ 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 17136772    941 RASTFYPLPEDIEAiQFVNEVTVQAfgENVVNMEARDD----------FGVPW 983
Cdd:pfam15275   79 PSSPFYPSPEDIED-QSVLEVPVQA--SPLPPLSPETSsllseevqewFSLPW 128
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 447-583 4.71e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 44.23  E-value: 4.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136772   447 IRKEGNQNRITEKLLQLKPEPMVDALEAPILPKWVAFKKKDKE--HESVPESPEV---PKQQPHQEdaivdhNAIKNQLE 521
Cdd:NF033838  358 VKEEAKEPRNEEKIKQAKAKVESKKAEATRLEKIKTDRKKAEEeaKRKAAEEDKVkekPAEQPQPA------PAPQPEKP 431

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17136772   522 VPKPDlKPKDQPKDEQRQDGQldvrvePQEDVRKVQKETLKRQPEDAPKHLPKAVAPKVTKT 583
Cdd:NF033838  432 APKPE-KPAEQPKAEKPADQQ------AEEDYARRSEEEYNRLTQQQPPKTEKPAQPSTPKT 486
 
Name Accession Description Interval E-value
PEHE pfam15275
PEHE domain; This domain was first identified in drosophila MSL1 (male-specific lethal 1). In ...
 866-983 8.85e-21

PEHE domain; This domain was first identified in drosophila MSL1 (male-specific lethal 1). In drosophila it binds to the histone acetyltransferase males-absent on the first protein (MOF) and to protein male-specific lethal-3 (MSL3).


Pssm-ID: 464607  Cd Length: 128  Bit Score: 89.08  E-value: 8.85e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136772    866 LEIPKWRDV---PVPPSSDKID-TELLSDATFERRHQKYVkdEVDRKCRDARYMKEQIRLEQLRMRR-NQDEVLVALDPL 940
Cdd:pfam15275    1 ILTPSWRVVdlnPLEDSEEDEDeIEDLSDEVFSKRHQKYE--EKERKRWDLWRIREQRRRESLRSRSyPSRNTPVPLGPQ 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 17136772    941 RASTFYPLPEDIEAiQFVNEVTVQAfgENVVNMEARDD----------FGVPW 983
Cdd:pfam15275   79 PSSPFYPSPEDIED-QSVLEVPVQA--SPLPPLSPETSsllseevqewFSLPW 128
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 447-583 4.71e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 44.23  E-value: 4.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17136772   447 IRKEGNQNRITEKLLQLKPEPMVDALEAPILPKWVAFKKKDKE--HESVPESPEV---PKQQPHQEdaivdhNAIKNQLE 521
Cdd:NF033838  358 VKEEAKEPRNEEKIKQAKAKVESKKAEATRLEKIKTDRKKAEEeaKRKAAEEDKVkekPAEQPQPA------PAPQPEKP 431

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17136772   522 VPKPDlKPKDQPKDEQRQDGQldvrvePQEDVRKVQKETLKRQPEDAPKHLPKAVAPKVTKT 583
Cdd:NF033838  432 APKPE-KPAEQPKAEKPADQQ------AEEDYARRSEEEYNRLTQQQPPKTEKPAQPSTPKT 486
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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