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Conserved domains on  [gi|24657961|ref|NP_477049|]
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Gp150, isoform D [Drosophila melanogaster]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
341-758 6.97e-23

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.70  E-value: 6.97e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  341 NELYAVNLTDVGLAIINPDTFVGNKKLRMLTISGNDLSVMSSIHYLLKSSSIEELDFSRNNLMELNPKAFSHLSNVVYIN 420
Cdd:COG4886   23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELD 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  421 LSQNslkklpeKAFEKVTLLEELDLSYNSLTELPRDIFNGTtlsilhlkyntfngdlhfgtkDLQQLDLSFNSIVQVhHS 500
Cdd:COG4886  103 LSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLT---------------------NLKELDLSNNQLTDL-PE 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  501 MFDKMPGLTNLNLKGNGIKKIqPDSFLTLKNLRHIDLSINDLDQISGMLfFKNSELDVIRLNDNpRLSQLPtdgflsysg 580
Cdd:COG4886  154 PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPEPL-GNLTNLEELDLSGN-QLTDLP--------- 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  581 eftvyyldisncaigplghKAFSTMPHLTTLKLAWNNINHLPReiFTGLHKLIDLDLSNNLITRMDDLIFMDNgeLTKLS 660
Cdd:COG4886  222 -------------------EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTN--LKTLD 278

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  661 LAGNPISRLSVRLFLPLHQLRCLDVNDCELTTLLSDRDLGAGYKIFDSLRSFNASGNLIKKISSEDVKSFKNLRSLDITN 740
Cdd:COG4886  279 LSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNL 358

                        410
                 ....*....|....*...
gi 24657961  741 NPLKCTPDFQEFISYVTL 758
Cdd:COG4886  359 LSLLLTLLLTLGLLGLLE 376
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
341-758 6.97e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.70  E-value: 6.97e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  341 NELYAVNLTDVGLAIINPDTFVGNKKLRMLTISGNDLSVMSSIHYLLKSSSIEELDFSRNNLMELNPKAFSHLSNVVYIN 420
Cdd:COG4886   23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELD 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  421 LSQNslkklpeKAFEKVTLLEELDLSYNSLTELPRDIFNGTtlsilhlkyntfngdlhfgtkDLQQLDLSFNSIVQVhHS 500
Cdd:COG4886  103 LSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLT---------------------NLKELDLSNNQLTDL-PE 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  501 MFDKMPGLTNLNLKGNGIKKIqPDSFLTLKNLRHIDLSINDLDQISGMLfFKNSELDVIRLNDNpRLSQLPtdgflsysg 580
Cdd:COG4886  154 PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPEPL-GNLTNLEELDLSGN-QLTDLP--------- 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  581 eftvyyldisncaigplghKAFSTMPHLTTLKLAWNNINHLPReiFTGLHKLIDLDLSNNLITRMDDLIFMDNgeLTKLS 660
Cdd:COG4886  222 -------------------EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTN--LKTLD 278

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  661 LAGNPISRLSVRLFLPLHQLRCLDVNDCELTTLLSDRDLGAGYKIFDSLRSFNASGNLIKKISSEDVKSFKNLRSLDITN 740
Cdd:COG4886  279 LSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNL 358

                        410
                 ....*....|....*...
gi 24657961  741 NPLKCTPDFQEFISYVTL 758
Cdd:COG4886  359 LSLLLTLLLTLGLLGLLE 376
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 343-667 1.96e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 91.06  E-value: 1.96e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961   343 LYAVNLTDVGLAIINPDTFVGN--------KKLRMLTISGNDLSvmSSIHYLL-KSSSIEELDFSRNNLMELNPKAFSHL 413
Cdd:PLN00113  182 NSLTNLTSLEFLTLASNQLVGQiprelgqmKSLKWIYLGYNNLS--GEIPYEIgGLTSLNHLDLVYNNLTGPIPSSLGNL 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961   414 SNVVYINLSQNSLK-KLPEKAFEkVTLLEELDLSYNSLT-ELPRDIFNGTTLSILHLKYNTFNGDLHFGTKD---LQQLD 488
Cdd:PLN00113  260 KNLQYLFLYQNKLSgPIPPSIFS-LQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTGKIPVALTSlprLQVLQ 338

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961   489 LSFNSIVQVHHSMFDKMPGLTNLNLKGNGIKKIQPDSFLTLKNLRHIDLSINDLD-QISGMLFFKNSeLDVIRLNDNPRL 567
Cdd:PLN00113  339 LWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEgEIPKSLGACRS-LRRVRLQDNSFS 417

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961   568 SQLPTdgflsysgEFT----VYYLDISNCAI-GPLGHKAFStMPHLTTLKLAWNNI-NHLPReiFTGLHKLIDLDLSNNL 641
Cdd:PLN00113  418 GELPS--------EFTklplVYFLDISNNNLqGRINSRKWD-MPSLQMLSLARNKFfGGLPD--SFGSKRLENLDLSRNQ 486

                         330       340
                  ....*....|....*....|....*.
gi 24657961   642 ITRMDDLIFMDNGELTKLSLAGNPIS 667
Cdd:PLN00113  487 FSGAVPRKLGSLSELMQLKLSENKLS 512
LRR_8 pfam13855
Leucine rich repeat;
606-666 5.25e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.99  E-value: 5.25e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24657961    606 PHLTTLKLAWNNINHLPREIFTGLHKLIDLDLSNNLITRMDDLIFMDNGELTKLSLAGNPI 666
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 602-743 6.38e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.18  E-value: 6.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  602 FSTMPHLTTLKLAWNNINHLPReiFTGLHKLIDLDLSNNLITRMDDLIFMDNgeLTKLSLAGNPISRLS----------- 670
Cdd:cd21340   20 LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIENLENLVN--LKKLYLGGNRISVVEglenltnleel 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  671 ----VRL-------FLP------LHQLRCLDVNDCELTTLlsdRDLgagyKIFDSLRSFNASGNLIKKIS--SEDVKSFK 731
Cdd:cd21340   96 hienQRLppgekltFDPrslaalSNSLRVLNISGNNIDSL---EPL----APLRNLEQLDASNNQISDLEelLDLLSSWP 168

                        170
                 ....*....|..
gi 24657961  732 NLRSLDITNNPL 743
Cdd:cd21340  169 SLRELDLTGNPV 180
LRR smart00370
Leucine-rich repeats, outliers;
440-460 5.23e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 5.23e-03
                            10        20
                    ....*....|....*....|.
gi 24657961     440 LEELDLSYNSLTELPRDIFNG 460
Cdd:smart00370    4 LRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
341-758 6.97e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.70  E-value: 6.97e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  341 NELYAVNLTDVGLAIINPDTFVGNKKLRMLTISGNDLSVMSSIHYLLKSSSIEELDFSRNNLMELNPKAFSHLSNVVYIN 420
Cdd:COG4886   23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELD 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  421 LSQNslkklpeKAFEKVTLLEELDLSYNSLTELPRDIFNGTtlsilhlkyntfngdlhfgtkDLQQLDLSFNSIVQVhHS 500
Cdd:COG4886  103 LSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLT---------------------NLKELDLSNNQLTDL-PE 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  501 MFDKMPGLTNLNLKGNGIKKIqPDSFLTLKNLRHIDLSINDLDQISGMLfFKNSELDVIRLNDNpRLSQLPtdgflsysg 580
Cdd:COG4886  154 PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPEPL-GNLTNLEELDLSGN-QLTDLP--------- 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  581 eftvyyldisncaigplghKAFSTMPHLTTLKLAWNNINHLPReiFTGLHKLIDLDLSNNLITRMDDLIFMDNgeLTKLS 660
Cdd:COG4886  222 -------------------EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLANLTN--LKTLD 278

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  661 LAGNPISRLSVRLFLPLHQLRCLDVNDCELTTLLSDRDLGAGYKIFDSLRSFNASGNLIKKISSEDVKSFKNLRSLDITN 740
Cdd:COG4886  279 LSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNL 358

                        410
                 ....*....|....*...
gi 24657961  741 NPLKCTPDFQEFISYVTL 758
Cdd:COG4886  359 LSLLLTLLLTLGLLGLLE 376
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 343-667 1.96e-18

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 91.06  E-value: 1.96e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961   343 LYAVNLTDVGLAIINPDTFVGN--------KKLRMLTISGNDLSvmSSIHYLL-KSSSIEELDFSRNNLMELNPKAFSHL 413
Cdd:PLN00113  182 NSLTNLTSLEFLTLASNQLVGQiprelgqmKSLKWIYLGYNNLS--GEIPYEIgGLTSLNHLDLVYNNLTGPIPSSLGNL 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961   414 SNVVYINLSQNSLK-KLPEKAFEkVTLLEELDLSYNSLT-ELPRDIFNGTTLSILHLKYNTFNGDLHFGTKD---LQQLD 488
Cdd:PLN00113  260 KNLQYLFLYQNKLSgPIPPSIFS-LQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTGKIPVALTSlprLQVLQ 338

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961   489 LSFNSIVQVHHSMFDKMPGLTNLNLKGNGIKKIQPDSFLTLKNLRHIDLSINDLD-QISGMLFFKNSeLDVIRLNDNPRL 567
Cdd:PLN00113  339 LWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEgEIPKSLGACRS-LRRVRLQDNSFS 417

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961   568 SQLPTdgflsysgEFT----VYYLDISNCAI-GPLGHKAFStMPHLTTLKLAWNNI-NHLPReiFTGLHKLIDLDLSNNL 641
Cdd:PLN00113  418 GELPS--------EFTklplVYFLDISNNNLqGRINSRKWD-MPSLQMLSLARNKFfGGLPD--SFGSKRLENLDLSRNQ 486

                         330       340
                  ....*....|....*....|....*.
gi 24657961   642 ITRMDDLIFMDNGELTKLSLAGNPIS 667
Cdd:PLN00113  487 FSGAVPRKLGSLSELMQLKLSENKLS 512
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
438-744 3.78e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.37  E-value: 3.78e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  438 TLLEELDLSYNSLTELPRDIFNGTTLSILHLKYNTFNGDLHFGTKDLQQLDLSFNSIVQVHHSMFDKMPGLTNLNLKGNG 517
Cdd:COG4886    4 LLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  518 IKKIQPDSFLTLKNLRHIDLSINDldqisgmLFFKNSELDVIRLNDNpRLSQLPTD-GFLSysgefTVYYLDISNCAIGP 596
Cdd:COG4886   84 LLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGN-QLTDLPEElANLT-----NLKELDLSNNQLTD 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  597 LGhKAFSTMPHLTTLKLAWNNINHLPREIFtGLHKLIDLDLSNNLITRMDDLIfMDNGELTKLSLAGNPISRLSVRLFlP 676
Cdd:COG4886  151 LP-EPLGNLTNLKSLDLSNNQLTDLPEELG-NLTNLKELDLSNNQITDLPEPL-GNLTNLEELDLSGNQLTDLPEPLA-N 226

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24657961  677 LHQLRCLDVNDCELTTLlsdRDLGAgykiFDSLRSFNASGNLIKKISSEdvKSFKNLRSLDITNNPLK 744
Cdd:COG4886  227 LTNLETLDLSNNQLTDL---PELGN----LTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLT 285
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 386-563 9.56e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 66.02  E-value: 9.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961   386 LLKSSSIEELDFSRNNLMELNPKAFSHLSNVVYINLSQNSLKKLPEKAFEKVTLLEELDLSYNSLT-ELPRDIFNGTTLS 464
Cdd:PLN00113  376 LCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQ 455

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961   465 ILHLKYNTFNGDL--HFGTKDLQQLDLSFNSIVQVHHSMFDKMPGLTNLNLKGNGIKKIQPDSFLTLKNLRHIDLSINdl 542
Cdd:PLN00113  456 MLSLARNKFFGGLpdSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHN-- 533

                         170       180
                  ....*....|....*....|.
gi 24657961   543 dQISGMLFFKNSELDVIRLND 563
Cdd:PLN00113  534 -QLSGQIPASFSEMPVLSQLD 553
LRR_8 pfam13855
Leucine rich repeat;
606-666 5.25e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.99  E-value: 5.25e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24657961    606 PHLTTLKLAWNNINHLPREIFTGLHKLIDLDLSNNLITRMDDLIFMDNGELTKLSLAGNPI 666
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 602-743 6.38e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 60.18  E-value: 6.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  602 FSTMPHLTTLKLAWNNINHLPReiFTGLHKLIDLDLSNNLITRMDDLIFMDNgeLTKLSLAGNPISRLS----------- 670
Cdd:cd21340   20 LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIENLENLVN--LKKLYLGGNRISVVEglenltnleel 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  671 ----VRL-------FLP------LHQLRCLDVNDCELTTLlsdRDLgagyKIFDSLRSFNASGNLIKKIS--SEDVKSFK 731
Cdd:cd21340   96 hienQRLppgekltFDPrslaalSNSLRVLNISGNNIDSL---EPL----APLRNLEQLDASNNQISDLEelLDLLSSWP 168

                        170
                 ....*....|..
gi 24657961  732 NLRSLDITNNPL 743
Cdd:cd21340  169 SLRELDLTGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
390-450 6.44e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.99  E-value: 6.44e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24657961    390 SSIEELDFSRNNLMELNPKAFSHLSNVVYINLSQNSLKKLPEKAFEKVTLLEELDLSYNSL 450
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
484-542 2.87e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 2.87e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 24657961    484 LQQLDLSFNSIVQVHHSMFDKMPGLTNLNLKGNGIKKIQPDSFLTLKNLRHIDLSINDL 542
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
583-642 9.77e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 9.77e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961    583 TVYYLDISNCAIGPLGHKAFSTMPHLTTLKLAWNNINHLPREIFTGLHKLIDLDLSNNLI 642
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 358-477 2.25e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.24  E-value: 2.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961   358 PDTFvGNKKLRMLTISGNDLSVMSSiHYLLKSSSIEELDFSRNNLMELNPKAFSHLSNVVYINLSQNSLKKLPEKAFEKV 437
Cdd:PLN00113  469 PDSF-GSKRLENLDLSRNQFSGAVP-RKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEM 546

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 24657961   438 TLLEELDLSYNSLT-ELPRDIFNGTTLSILHLKYNTFNGDL 477
Cdd:PLN00113  547 PVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLHGSL 587
LRR_8 pfam13855
Leucine rich repeat;
506-565 4.09e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 4.09e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961    506 PGLTNLNLKGNGIKKIQPDSFLTLKNLRHIDLSINDLDQISGMLFFKNSELDVIRLNDNP 565
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
358-518 4.54e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.85  E-value: 4.54e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961   358 PDTFVGNkkLRMLTISGNDLSVMSSIhyllKSSSIEELDFSRNNLMELNPKAFSHLSNVVyinLSQNSLKKLPEKAFEKv 437
Cdd:PRK15370  215 PENLQGN--IKTLYANSNQLTSIPAT----LPDTIQEMELSINRITELPERLPSALQSLD---LFHNKISCLPENLPEE- 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961   438 tlLEELDLSYNSLTELPRDIFNGttlsILHLkyNTFNGDLHFGTK----DLQQLDLSFNSIVQVHHSMfdkMPGLTNLNL 513
Cdd:PRK15370  285 --LRYLSVYDNSIRTLPAHLPSG----ITHL--NVQSNSLTALPEtlppGLKTLEAGENALTSLPASL---PPELQVLDV 353


                  ....*
gi 24657961   514 KGNGI 518
Cdd:PRK15370  354 SKNQI 358
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 389-664 5.12e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.62  E-value: 5.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961   389 SSSIEELDFSRNNLMELNPKAFSHLSNVVYINLSQNSLK-KLPEKAFE----------------------KVTLLEELDL 445
Cdd:PLN00113   68 SSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTtssslrylnlsnnnftgsiprgSIPNLETLDL 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961   446 SYNSLT-ELPRDIFNGTTLSILHLKYNTFNGDLHFGTKDLQQLD---LSFNSIVQVHHSMFDKMPGLTNLNLKGNGIKKI 521
Cdd:PLN00113  148 SNNMLSgEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEfltLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGE 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961   522 QPDSFLTLKNLRHIDLSINDLDQISGMLFFKNSELDVIRLNDNPRLSQLP--------------TDGFLsySGEFTVYYL 587
Cdd:PLN00113  228 IPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPpsifslqklisldlSDNSL--SGEIPELVI 305

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961   588 DISNCAIGPLGHKAF--------STMPHLTTLKLaWNniNHLPREIFTGLHK---LIDLDLS-NNLITRMDDLIfMDNGE 655
Cdd:PLN00113  306 QLQNLEILHLFSNNFtgkipvalTSLPRLQVLQL-WS--NKFSGEIPKNLGKhnnLTVLDLStNNLTGEIPEGL-CSSGN 381


                  ....*....
gi 24657961   656 LTKLSLAGN 664
Cdd:PLN00113  382 LFKLILFSN 390
LRR_8 pfam13855
Leucine rich repeat;
440-518 1.37e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 1.37e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24657961    440 LEELDLSYNSLTELPRDIFngttlsilhlkyntfngdlhFGTKDLQQLDLSFNSIVQVHHSMFDKMPGLTNLNLKGNGI 518
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAF--------------------KGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 389-475 4.22e-05

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 44.07  E-value: 4.22e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961    389 SSSIEELDFSrNNLMELNPKAFSHlSNVVYINLSqNSLKKLPEKAFEKVTLLEELDLSyNSLTELPRDIFNGTTL----- 463
Cdd:pfam13306   33 CTSLKSITLP-SSLTSIGSYAFYN-CSLTSITIP-SSLTSIGEYAFSNCSNLKSITLP-SNLTSIGSYAFSNCSLksiti 108

                           90
                   ....*....|....
gi 24657961    464 --SILHLKYNTFNG 475
Cdd:pfam13306  109 psSVTTIGSYAFSN 122
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 502-670 4.43e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.93  E-value: 4.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  502 FDKMPGLTNLNLKGNGIKKIQPdsFLTLKNLRHIDLSINDLDQISGMLFFKN-SELDVirlnDNPRLSqlPTDGFLSysG 580
Cdd:cd21340   42 LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVEGLENLTNlEELHI----ENQRLP--PGEKLTF--D 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  581 EFTVYYldISNCaigplghkafstmphLTTLKLAWNNINHLprEIFTGLHKLIDLDLSNNLITRMDDL--IFMDNGELTK 658
Cdd:cd21340  112 PRSLAA--LSNS---------------LRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEELldLLSSWPSLRE 172

                        170
                 ....*....|..
gi 24657961  659 LSLAGNPISRLS 670
Cdd:cd21340  173 LDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
635-690 7.06e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 7.06e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 24657961    635 LDLSNNLITRMDDLIFMDNGELTKLSLAGNPISRLSVRLFLPLHQLRCLDVNDCEL 690
Cdd:pfam13855    6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 586-745 8.78e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.81  E-value: 8.78e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  586 YLDISNCAIGPLG---HKAFSTMPHLTTLKLAWNNINHLP-REIFTGL----HKLIDLDLSNNLITR--MDDL--IFMDN 653
Cdd:cd00116   85 ELDLSDNALGPDGcgvLESLLRSSSLQELKLNNNGLGDRGlRLLAKGLkdlpPALEKLVLGRNRLEGasCEALakALRAN 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  654 GELTKLSLAGNPIS----RLSVRLFLPLHQLRCLDVNDCELTTlLSDRDLGAGYKIFDSLRSFNASGNLIK-----KISS 724
Cdd:cd00116  165 RDLKELNLANNGIGdagiRALAEGLKANCNLEVLDLNNNGLTD-EGASALAETLASLKSLEVLNLGDNNLTdagaaALAS 243

                        170       180
                 ....*....|....*....|.
gi 24657961  725 EDVKSFKNLRSLDITNNPLKC 745
Cdd:cd00116  244 ALLSPNISLLTLSLSCNDITD 264
LRR_8 pfam13855
Leucine rich repeat;
414-471 8.85e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 8.85e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 24657961    414 SNVVYINLSQNSLKKLPEKAFEKVTLLEELDLSYNSLTELPRDIFNG-TTLSILHLKYN 471
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
318-377 1.09e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 1.09e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961    318 NVASIKIANCTLEYLHAEAFHGLNELYAVNLTDVGLAIINPDTFVGNKKLRMLTISGNDL 377
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 392-477 1.40e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 45.96  E-value: 1.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961   392 IEELDFSRNNLMELNPKAFSHLSNVVYINLSQNSLKKLPEKAFEKVTLLEELDLSYNSLT-ELPRDIFNGTTLSILHLKY 470
Cdd:PLN03150  420 IDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNG 499


                  ....*..
gi 24657961   471 NTFNGDL 477
Cdd:PLN03150  500 NSLSGRV 506
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 367-444 1.56e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.39  E-value: 1.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  367 LRMLTISGNDLSVMSSIHYLlksSSIEELDFSRNNLMELNP--KAFSHLSNVVYINLSQNSLKKLPeKAFEKVTL----L 440
Cdd:cd21340  122 LRVLNISGNNIDSLEPLAPL---RNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP-KYRDKIILasksL 197


                 ....
gi 24657961  441 EELD 444
Cdd:cd21340  198 EVLD 201
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 363-518 1.64e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 45.55  E-value: 1.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  363 GNKKLRMLTISGNDLS---VMSSIHYLLKSSSIEELDFSRNNLMELNPKAFShlsnvvyinlsqnslkklpeKAFEKVTL 439
Cdd:COG5238  234 GNKSLTTLDLSNNQIGdegVIALAEALKNNTTVETLYLSGNQIGAEGAIALA--------------------KALQGNTT 293

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  440 LEELDLSYNSLTE-----LPRDIFNGTTLSILHLKYNTFNGD--------LHFGTKdLQQLDLSFNSI----VQVHHSMF 502
Cdd:COG5238  294 LTSLDLSVNRIGDegaiaLAEGLQGNKTLHTLNLAYNGIGAQgaialakaLQENTT-LHSLDLSDNQIgdegAIALAKYL 372

                        170
                 ....*....|....*.
gi 24657961  503 DKMPGLTNLNLKGNGI 518
Cdd:COG5238  373 EGNTTLRELNLGKNNI 388
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
315-513 1.80e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.31  E-value: 1.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  315 GLKNVASIKIANCTLEYLHaEAFHGLNELYAVNLTDVGLAIInPDTFVGNKKLRMLTISGNDLSVMSSIHYLlksSSIEE 394
Cdd:COG4886  180 NLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPELGNL---TNLEE 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  395 LDFSRNNLMELNPkaFSHLSNVVYINLSQNSLKKLPEKAFEKVTLLEELDLSYNSLTELPRDIFNGTTLSILHLKYNTFN 474
Cdd:COG4886  255 LDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKG 332

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 24657961  475 GDLHFGTKDLQQLDLSFNSIVQVHHSMFDKMPGLTNLNL 513
Cdd:COG4886  333 LLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGL 371
LRR_8 pfam13855
Leucine rich repeat;
342-426 2.64e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 2.64e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961    342 ELYAVNLTDVGLAIINPDTFVGNKKLRMltisgndlsvmssihyllksssieeLDFSRNNLMELNPKAFSHLSNVVYINL 421
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKV-------------------------LDLSNNLLTTLSPGAFSGLPSLRYLDL 56


                   ....*
gi 24657961    422 SQNSL 426
Cdd:pfam13855   57 SGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 434-690 3.12e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.27  E-value: 3.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  434 FEKVTLLEELDLSYNSLTE-----LPRDIFNGTTLSILHLKYNtFNGDLHFGTKD----------LQQLDLSFNSI---- 494
Cdd:cd00116   19 LPKLLCLQVLRLEGNTLGEeaakaLASALRPQPSLKELCLSLN-ETGRIPRGLQSllqgltkgcgLQELDLSDNALgpdg 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  495 VQVHHSmFDKMPGLTNLNLKGNGIK----KIQPDSFLTLK-NLRHIDLSINDL-----DQISGmLFFKNSELDVIRLNDN 564
Cdd:cd00116   98 CGVLES-LLRSSSLQELKLNNNGLGdrglRLLAKGLKDLPpALEKLVLGRNRLegascEALAK-ALRANRDLKELNLANN 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  565 PRLSQLPT---DGFLSYSGeftVYYLDISNCAIGPLGHKA----FSTMPHLTTLKLAWNNIN-----HLPREIFTGLHKL 632
Cdd:cd00116  176 GIGDAGIRalaEGLKANCN---LEVLDLNNNGLTDEGASAlaetLASLKSLEVLNLGDNNLTdagaaALASALLSPNISL 252

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24657961  633 IDLDLSNNLITR---MDDLIFMDNGE-LTKLSLAGNPISRLSVRL-FLPLHQLRC----LDVNDCEL 690
Cdd:cd00116  253 LTLSLSCNDITDdgaKDLAEVLAEKEsLLELDLRGNKFGEEGAQLlAESLLEPGNelesLWVKDDSF 319
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 374-619 8.05e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.73  E-value: 8.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  374 GNDLSVMSSIHYLLKSSSIEELDFSRNNLMELNP---KAFSHLSNVVYINLSQNSLKKLPEKAFEKVTL-----LEELDL 445
Cdd:cd00116   65 RIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCgvlESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKdlppaLEKLVL 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  446 SYNSLT-ELPRDIfnGTTLSilhlkyntFNGDLHfgtkdlqQLDLSFNSIvqvhhsmfdkmpgltnlnlKGNGIKKIQPD 524
Cdd:cd00116  145 GRNRLEgASCEAL--AKALR--------ANRDLK-------ELNLANNGI-------------------GDAGIRALAEG 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  525 sFLTLKNLRHIDLSINDL----DQISGMLFFKNSELDVIRLNDNPrLSQLPTDGFLS--YSGEFTVYYLDISNCAIGPLG 598
Cdd:cd00116  189 -LKANCNLEVLDLNNNGLtdegASALAETLASLKSLEVLNLGDNN-LTDAGAAALASalLSPNISLLTLSLSCNDITDDG 266

                        250       260
                 ....*....|....*....|....*
gi 24657961  599 HKAFST----MPHLTTLKLAWNNIN 619
Cdd:cd00116  267 AKDLAEvlaeKESLLELDLRGNKFG 291
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 365-522 3.50e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 3.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  365 KKLRMLTISGNDLSVMSSIHYLlksSSIEELDFSRNNLMELNPkaFSHLSNVVYINLSQNSLKKLpeKAFEKVTLLEELD 444
Cdd:cd21340   24 KNLKVLYLYDNKITKIENLEFL---TNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVV--EGLENLTNLEELH 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  445 LSY------NSLTELPRDIFN-GTTLSILHLKYN--TFNGDLHFGTKdLQQLDLSFNSIVQVHH--SMFDKMPGLTNLNL 513
Cdd:cd21340   97 IENqrlppgEKLTFDPRSLAAlSNSLRVLNISGNniDSLEPLAPLRN-LEQLDASNNQISDLEEllDLLSSWPSLRELDL 175


                 ....*....
gi 24657961  514 KGNGIKKIQ 522
Cdd:cd21340  176 TGNPVCKKP 184
LRR smart00370
Leucine-rich repeats, outliers;
440-460 5.23e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 5.23e-03
                            10        20
                    ....*....|....*....|.
gi 24657961     440 LEELDLSYNSLTELPRDIFNG 460
Cdd:smart00370    4 LRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
440-460 5.23e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 5.23e-03
                            10        20
                    ....*....|....*....|.
gi 24657961     440 LEELDLSYNSLTELPRDIFNG 460
Cdd:smart00369    4 LRELDLSNNQLSSLPPGAFQG 24
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 390-565 6.55e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 6.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  390 SSIEELDFSRNnLMELnpkafsHLSNvvyinlsqNSLKKLPEkaFEKVTLLEELDLSYNSLTELprdifNG----TTLSI 465
Cdd:cd21340   37 TKIENLEFLTN-LTHL------YLQN--------NQIEKIEN--LENLVNLKKLYLGGNRISVV-----EGlenlTNLEE 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24657961  466 LHLKYntfngdlhfgtkdlQQLD----LSFNSivqvhHSMFDKMPGLTNLNLKGNGIKKIQPdsFLTLKNLRHIDLS--- 538
Cdd:cd21340   95 LHIEN--------------QRLPpgekLTFDP-----RSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASnnq 153

                        170       180
                 ....*....|....*....|....*..
gi 24657961  539 INDLDQISGMLfFKNSELDVIRLNDNP 565
Cdd:cd21340  154 ISDLEELLDLL-SSWPSLRELDLTGNP 179
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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