splicing factor 3A subunit 3 (SF3A3) family protein is involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex
SF3a60/Prp9 C-terminal; This domain corresponds to the C-terminal region of SF3a60 subunit ...
384-503
3.63e-84
SF3a60/Prp9 C-terminal; This domain corresponds to the C-terminal region of SF3a60 subunit (Prp9 in yeast counterpart) from the highly conserved heterotrimeric complex SF3a found in eukaryotes. It is essential for pre-mRNA splicing that functions in spliceosome assembly within the mature U2 snRNP (small ribonucleoprotein particle). This domain has two conserved sequence motifs: PIP and CEICG. It contains a zinc-finger domain of the C2H2-type which might be important for RNA binding and protein-protein interactions with components of the SF3b complex.
:
Pssm-ID: 432197 Cd Length: 120 Bit Score: 255.51 E-value: 3.63e-84
SF3a60/Prp9 C-terminal; This domain corresponds to the C-terminal region of SF3a60 subunit ...
384-503
3.63e-84
SF3a60/Prp9 C-terminal; This domain corresponds to the C-terminal region of SF3a60 subunit (Prp9 in yeast counterpart) from the highly conserved heterotrimeric complex SF3a found in eukaryotes. It is essential for pre-mRNA splicing that functions in spliceosome assembly within the mature U2 snRNP (small ribonucleoprotein particle). This domain has two conserved sequence motifs: PIP and CEICG. It contains a zinc-finger domain of the C2H2-type which might be important for RNA binding and protein-protein interactions with components of the SF3b complex.
Pssm-ID: 432197 Cd Length: 120 Bit Score: 255.51 E-value: 3.63e-84
Replication stress response SDE2 C-terminal; This domain represents the C-terminal region of ...
223-301
2.22e-29
Replication stress response SDE2 C-terminal; This domain represents the C-terminal region of the Replication stress response SDE2, a genome surveillance factor. It contains the DNA-binding SAP domain, frequently found in proteins involved in DNA repair. SDE2 C-terminal domain must be cleaved from its N-terminal at a diglycine motif within the ubiquitin-like fold, after Proliferating cell nuclear antigen (PCNA) interaction. This generates a functional protein that negatively regulates damage-inducible PCNA monoubiquitination, which then is proteolytically degraded to allow S phase progression and replication fork recovery in response to DNA damage.
Pssm-ID: 463835 Cd Length: 80 Bit Score: 110.43 E-value: 2.22e-29
SF3a60/Prp9 C-terminal; This domain corresponds to the C-terminal region of SF3a60 subunit ...
384-503
3.63e-84
SF3a60/Prp9 C-terminal; This domain corresponds to the C-terminal region of SF3a60 subunit (Prp9 in yeast counterpart) from the highly conserved heterotrimeric complex SF3a found in eukaryotes. It is essential for pre-mRNA splicing that functions in spliceosome assembly within the mature U2 snRNP (small ribonucleoprotein particle). This domain has two conserved sequence motifs: PIP and CEICG. It contains a zinc-finger domain of the C2H2-type which might be important for RNA binding and protein-protein interactions with components of the SF3b complex.
Pssm-ID: 432197 Cd Length: 120 Bit Score: 255.51 E-value: 3.63e-84
Replication stress response SDE2 C-terminal; This domain represents the C-terminal region of ...
223-301
2.22e-29
Replication stress response SDE2 C-terminal; This domain represents the C-terminal region of the Replication stress response SDE2, a genome surveillance factor. It contains the DNA-binding SAP domain, frequently found in proteins involved in DNA repair. SDE2 C-terminal domain must be cleaved from its N-terminal at a diglycine motif within the ubiquitin-like fold, after Proliferating cell nuclear antigen (PCNA) interaction. This generates a functional protein that negatively regulates damage-inducible PCNA monoubiquitination, which then is proteolytically degraded to allow S phase progression and replication fork recovery in response to DNA damage.
Pssm-ID: 463835 Cd Length: 80 Bit Score: 110.43 E-value: 2.22e-29
Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9; SF3A3 is one of the components of the ...
128-177
6.04e-18
Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9; SF3A3 is one of the components of the SF3a splicing factor complex of the mature U2 snRNP (small nuclear ribonucleoprotein particle). In yeast, SF3a shows a bifurcated assembly structure of three subunits, Prp9 (subunit 3), Prp11 (subunit 2) and Prp21 (subunit 1). Prp9 and Prp21 were not thought to interact with each other but the alpha1 helix of Prp9 does make important contacts with the SURP2 domain of Prp21, thus the two do interact via a bidentate-binding mode. Prp9 harbours a major binding site for stem-loop IIa of U2 snRNA.
Pssm-ID: 465279 Cd Length: 50 Bit Score: 77.18 E-value: 6.04e-18
Splicing factor SF3a60 binding domain; This domain is found in eukaryotes. This domain is ...
74-99
2.47e-07
Splicing factor SF3a60 binding domain; This domain is found in eukaryotes. This domain is about 30 amino acids in length. This domain has a single completely conserved residue Y that may be functionally important. SF3a60 makes up the SF3a complex with SF3a66 and SF3a120. This domain is the binding site of SF3a60 for SF3a120. The SF3a complex is part of the spliceosome, a protein complex involved in splicing mRNA after transcription.
Pssm-ID: 463461 Cd Length: 27 Bit Score: 46.66 E-value: 2.47e-07
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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