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Conserved domains on  [gi|17137350|ref|NP_477242|]
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defective proventriculus, isoform A [Drosophila melanogaster]

Protein Classification

homeobox domain-containing protein( domain architecture ID 11243845)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ULD pfam16534
Ubiquitin-like oligomerization domain of SATB; ULD is an N-terminal oligomerization domain of ...
 250-359 1.72e-52

Ubiquitin-like oligomerization domain of SATB; ULD is an N-terminal oligomerization domain of SATB or special AT-rich sequence-binding proteins. SATBs are global chromatin organizers and regulators of gene expression that are essential for T-cell development, breast cancer tumour growth and metastasis. SATBs assemble into a tetramer via the ULD domain, and the tetramerization of SATBs are essential for recognising specific DNA sequences (such as multiple AT-rich DNA fragments). Thus, SATBs may regulate gene expression directly by binding to various promoters and upstream regions and thereby influencing promoter activity.


:

Pssm-ID: 465165  Cd Length: 105  Bit Score: 178.69  E-value: 1.72e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137350    250 KSLPLHCVVESVHSLHASLTIDTRQPwkrrpNIETDSYVIIAAATPWSEIVQTALQRLGYSQEVANTARGSLIIKHWKPI 329
Cdd:pfam16534    1 KSLPVHCVVEQVESLQESNECDERTP-----NVEHDSYVIIPKDTLFSDLVETALLRLGYSHSSAAQAKGSIQIKNWKPL 75

                           90       100       110
                   ....*....|....*....|....*....|
gi 17137350    330 PLEQISDNPAVPVSDIVGELTSVITLRIVI 359
Cdd:pfam16534   76 SLESITDDPDATVGDMLGDLTTVATLRIQL 105
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 556-623 1.77e-11

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


:

Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 59.96  E-value: 1.77e-11
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17137350     556 KTRMRTSFDPEmELPKLQKWFADNPHPSRQQIQTYVVQLNalesrrgrkpLDVNNVVYWFKNARAAQK 623
Cdd:smart00389    1 KRRKRTSFTPE-QLEELEKEFQKNPYPSREEREELAKKLG----------LSERQVKVWFQNRRAKWK 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 928-995 3.89e-10

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


:

Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 56.49  E-value: 3.89e-10
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17137350     928 RKRNRTFIDPvTEVPKLEQWFAMNTHPSHNLILKYTEDLNtMPYRQkfprlesknVQFWFKNRRAKCK 995
Cdd:smart00389    1 KRRKRTSFTP-EQLEELEKEFQKNPYPSREEREELAKKLG-LSERQ---------VKVWFQNRRAKWK 57
 
Name Accession Description Interval E-value
ULD pfam16534
Ubiquitin-like oligomerization domain of SATB; ULD is an N-terminal oligomerization domain of ...
 250-359 1.72e-52

Ubiquitin-like oligomerization domain of SATB; ULD is an N-terminal oligomerization domain of SATB or special AT-rich sequence-binding proteins. SATBs are global chromatin organizers and regulators of gene expression that are essential for T-cell development, breast cancer tumour growth and metastasis. SATBs assemble into a tetramer via the ULD domain, and the tetramerization of SATBs are essential for recognising specific DNA sequences (such as multiple AT-rich DNA fragments). Thus, SATBs may regulate gene expression directly by binding to various promoters and upstream regions and thereby influencing promoter activity.


Pssm-ID: 465165  Cd Length: 105  Bit Score: 178.69  E-value: 1.72e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137350    250 KSLPLHCVVESVHSLHASLTIDTRQPwkrrpNIETDSYVIIAAATPWSEIVQTALQRLGYSQEVANTARGSLIIKHWKPI 329
Cdd:pfam16534    1 KSLPVHCVVEQVESLQESNECDERTP-----NVEHDSYVIIPKDTLFSDLVETALLRLGYSHSSAAQAKGSIQIKNWKPL 75

                           90       100       110
                   ....*....|....*....|....*....|
gi 17137350    330 PLEQISDNPAVPVSDIVGELTSVITLRIVI 359
Cdd:pfam16534   76 SLESITDDPDATVGDMLGDLTTVATLRIQL 105
SATB1_N cd11585
N-terminal domain of SATB1 and similar proteins; SATB1, the special AT-rich sequence-binding ...
 252-358 1.64e-49

N-terminal domain of SATB1 and similar proteins; SATB1, the special AT-rich sequence-binding protein 1, is involved in organizing chromosomal loci into distinct loops, creating a "loopscape" that has a direct bearing on gene expression. This N-terminal domain, which may be involved in various interactions with chromatin proteins, resembles a ubiquitin domain and has been shown to form tetramers, a function critical to SATB1-DNA interactions. The related Drosophila homeobox gene defective proventriculus (dve) plays a key role in the functional specification during endoderm development.


Pssm-ID: 211426  Cd Length: 100  Bit Score: 170.20  E-value: 1.64e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137350  252 LPLHCVVESVHSLHASltidtrqPWKRRPNIETDSYVIIAAATPWSEIVQTALQRLGYSQEVANTARGSLIIKHWKPIPL 331
Cdd:cd11585    1 LPVHCVVETVDSLHES-------VWRRRPRVETDSYVIIPKDTLFNQLVETALLRLGYSHSSAASAKGLIQIKNWKPLPF 73

                         90       100
                 ....*....|....*....|....*..
gi 17137350  332 EQISDNPAVPVSDIVGELTSVITLRIV 358
Cdd:cd11585   74 DQITDNPDATVGDMLGELTHVATLRIQ 100
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 556-623 1.77e-11

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 59.96  E-value: 1.77e-11
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17137350     556 KTRMRTSFDPEmELPKLQKWFADNPHPSRQQIQTYVVQLNalesrrgrkpLDVNNVVYWFKNARAAQK 623
Cdd:smart00389    1 KRRKRTSFTPE-QLEELEKEFQKNPYPSREEREELAKKLG----------LSERQVKVWFQNRRAKWK 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 928-995 3.89e-10

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 56.49  E-value: 3.89e-10
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17137350     928 RKRNRTFIDPvTEVPKLEQWFAMNTHPSHNLILKYTEDLNtMPYRQkfprlesknVQFWFKNRRAKCK 995
Cdd:smart00389    1 KRRKRTSFTP-EQLEELEKEFQKNPYPSREEREELAKKLG-LSERQ---------VKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 558-626 5.31e-10

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 56.10  E-value: 5.31e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17137350  558 RMRTSFDPEmELPKLQKWFADNPHPSRQQIQTYVVQLNalesrrgrkpLDVNNVVYWFKNARAAQKRAE 626
Cdd:cd00086    2 RKRTRFTPE-QLEELEKEFEKNPYPSREEREELAKELG----------LTERQVKIWFQNRRAKLKRSE 59
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 929-998 5.39e-09

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 53.02  E-value: 5.39e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137350  929 KRNRTFIDPvTEVPKLEQWFAMNTHPSHNLILKYTEDLNtMPYRQkfprlesknVQFWFKNRRAKCKRLK 998
Cdd:cd00086    1 RRKRTRFTP-EQLEELEKEFEKNPYPSREEREELAKELG-LTERQ---------VKIWFQNRRAKLKRSE 59
Homeodomain pfam00046
Homeodomain;
558-624 1.98e-08

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 51.35  E-value: 1.98e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17137350    558 RMRTSFDPEmELPKLQKWFADNPHPSRQQIQTYVVQLNalesrrgrkpLDVNNVVYWFKNARAAQKR 624
Cdd:pfam00046    2 RKRTTFTPE-QLEELEKEFQENPYPSAEEREELAAQLG----------LTERQVKVWFQNRRAKWKR 57
Homeodomain pfam00046
Homeodomain;
927-996 2.41e-08

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 51.35  E-value: 2.41e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137350    927 RRKRnRTFIDPVTEVpkLEQWFAMNTHPSHNLILKYTEDLNtmpyrqkfprLESKNVQFWFKNRRAKCKR 996
Cdd:pfam00046    1 RRKR-TTFTPEQLEE--LEKEFQENPYPSAEEREELAAQLG----------LTERQVKVWFQNRRAKWKR 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
923-996 7.63e-04

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 41.27  E-value: 7.63e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17137350  923 SNEERRKRNRTFIDpvtEVPKLEQWFAMNTHPSHNLILKYTEDLNTMPyrqkfprlesKNVQFWFKNRRAKCKR 996
Cdd:COG5576   48 SSPPKSKRRRTTDE---QLMVLEREFEINPYPSSITRIKLSLLLNMPP----------KSVQIWFQNKRAKEKK 108
 
Name Accession Description Interval E-value
ULD pfam16534
Ubiquitin-like oligomerization domain of SATB; ULD is an N-terminal oligomerization domain of ...
 250-359 1.72e-52

Ubiquitin-like oligomerization domain of SATB; ULD is an N-terminal oligomerization domain of SATB or special AT-rich sequence-binding proteins. SATBs are global chromatin organizers and regulators of gene expression that are essential for T-cell development, breast cancer tumour growth and metastasis. SATBs assemble into a tetramer via the ULD domain, and the tetramerization of SATBs are essential for recognising specific DNA sequences (such as multiple AT-rich DNA fragments). Thus, SATBs may regulate gene expression directly by binding to various promoters and upstream regions and thereby influencing promoter activity.


Pssm-ID: 465165  Cd Length: 105  Bit Score: 178.69  E-value: 1.72e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137350    250 KSLPLHCVVESVHSLHASLTIDTRQPwkrrpNIETDSYVIIAAATPWSEIVQTALQRLGYSQEVANTARGSLIIKHWKPI 329
Cdd:pfam16534    1 KSLPVHCVVEQVESLQESNECDERTP-----NVEHDSYVIIPKDTLFSDLVETALLRLGYSHSSAAQAKGSIQIKNWKPL 75

                           90       100       110
                   ....*....|....*....|....*....|
gi 17137350    330 PLEQISDNPAVPVSDIVGELTSVITLRIVI 359
Cdd:pfam16534   76 SLESITDDPDATVGDMLGDLTTVATLRIQL 105
SATB1_N cd11585
N-terminal domain of SATB1 and similar proteins; SATB1, the special AT-rich sequence-binding ...
 252-358 1.64e-49

N-terminal domain of SATB1 and similar proteins; SATB1, the special AT-rich sequence-binding protein 1, is involved in organizing chromosomal loci into distinct loops, creating a "loopscape" that has a direct bearing on gene expression. This N-terminal domain, which may be involved in various interactions with chromatin proteins, resembles a ubiquitin domain and has been shown to form tetramers, a function critical to SATB1-DNA interactions. The related Drosophila homeobox gene defective proventriculus (dve) plays a key role in the functional specification during endoderm development.


Pssm-ID: 211426  Cd Length: 100  Bit Score: 170.20  E-value: 1.64e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137350  252 LPLHCVVESVHSLHASltidtrqPWKRRPNIETDSYVIIAAATPWSEIVQTALQRLGYSQEVANTARGSLIIKHWKPIPL 331
Cdd:cd11585    1 LPVHCVVETVDSLHES-------VWRRRPRVETDSYVIIPKDTLFNQLVETALLRLGYSHSSAASAKGLIQIKNWKPLPF 73

                         90       100
                 ....*....|....*....|....*..
gi 17137350  332 EQISDNPAVPVSDIVGELTSVITLRIV 358
Cdd:cd11585   74 DQITDNPDATVGDMLGELTHVATLRIQ 100
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 556-623 1.77e-11

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 59.96  E-value: 1.77e-11
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17137350     556 KTRMRTSFDPEmELPKLQKWFADNPHPSRQQIQTYVVQLNalesrrgrkpLDVNNVVYWFKNARAAQK 623
Cdd:smart00389    1 KRRKRTSFTPE-QLEELEKEFQKNPYPSREEREELAKKLG----------LSERQVKVWFQNRRAKWK 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 928-995 3.89e-10

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 56.49  E-value: 3.89e-10
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17137350     928 RKRNRTFIDPvTEVPKLEQWFAMNTHPSHNLILKYTEDLNtMPYRQkfprlesknVQFWFKNRRAKCK 995
Cdd:smart00389    1 KRRKRTSFTP-EQLEELEKEFQKNPYPSREEREELAKKLG-LSERQ---------VKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 558-626 5.31e-10

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 56.10  E-value: 5.31e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17137350  558 RMRTSFDPEmELPKLQKWFADNPHPSRQQIQTYVVQLNalesrrgrkpLDVNNVVYWFKNARAAQKRAE 626
Cdd:cd00086    2 RKRTRFTPE-QLEELEKEFEKNPYPSREEREELAKELG----------LTERQVKIWFQNRRAKLKRSE 59
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 929-998 5.39e-09

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 53.02  E-value: 5.39e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137350  929 KRNRTFIDPvTEVPKLEQWFAMNTHPSHNLILKYTEDLNtMPYRQkfprlesknVQFWFKNRRAKCKRLK 998
Cdd:cd00086    1 RRKRTRFTP-EQLEELEKEFEKNPYPSREEREELAKELG-LTERQ---------VKIWFQNRRAKLKRSE 59
Homeodomain pfam00046
Homeodomain;
558-624 1.98e-08

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 51.35  E-value: 1.98e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17137350    558 RMRTSFDPEmELPKLQKWFADNPHPSRQQIQTYVVQLNalesrrgrkpLDVNNVVYWFKNARAAQKR 624
Cdd:pfam00046    2 RKRTTFTPE-QLEELEKEFQENPYPSAEEREELAAQLG----------LTERQVKVWFQNRRAKWKR 57
Homeodomain pfam00046
Homeodomain;
927-996 2.41e-08

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 51.35  E-value: 2.41e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137350    927 RRKRnRTFIDPVTEVpkLEQWFAMNTHPSHNLILKYTEDLNtmpyrqkfprLESKNVQFWFKNRRAKCKR 996
Cdd:pfam00046    1 RRKR-TTFTPEQLEE--LEKEFQENPYPSAEEREELAAQLG----------LTERQVKVWFQNRRAKWKR 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
923-996 7.63e-04

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 41.27  E-value: 7.63e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17137350  923 SNEERRKRNRTFIDpvtEVPKLEQWFAMNTHPSHNLILKYTEDLNTMPyrqkfprlesKNVQFWFKNRRAKCKR 996
Cdd:COG5576   48 SSPPKSKRRRTTDE---QLMVLEREFEINPYPSSITRIKLSLLLNMPP----------KSVQIWFQNKRAKEKK 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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