NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|17137668|ref|NP_477428|]
View 

excitatory amino acid transporter 1, isoform A [Drosophila melanogaster]

Protein Classification

dicarboxylate/amino acid:cation symporter( domain architecture ID 10003465)

dicarboxylate/amino acid:cation symporter facilitates H+ or Na+ symport with C4-dicarboxylates, dicarboxylic amino acids (aspartate, glutamate) or other amino acids; belongs to the sodium:dicarboxylate symporter family

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
20-448 9.98e-111

Na+/H+-dicarboxylate symporter [Energy production and conversion];


:

Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 333.23  E-value: 9.98e-111
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668  20 LTMATVIGVFVGGLIGFIIKNSTGEWskreimyISFPGEIFLRMLKCLIVPLLVSSITSAIGGL-DLSMSSKIATRAITY 98
Cdd:COG1301   5 LTLQILIALVLGILLGLLLPELVAAV-------LKPLGDIFINLLKMIVVPLVFFSIVVGIASLgDLKKLGRIGGKTLLY 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668  99 YFVTTISAVILGICLVTTLRPGQGAKIVETQTESIDKAskvlTPDTLMDLVRNMFTDNIIQstmfqhrteiyentsispa 178
Cdd:COG1301  78 FLVTTTIALVIGLVVANLFQPGAGLNLDLADAAAAEAA----EAPSLLDFLLNIIPSNIFE------------------- 134
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668 179 qPMENwefksaqregSNVLGLVMFSVILGTTIGRMREKGQLLQDFFTTLSEAMMTITSWVIWISPLGVAFLIAAKIIEME 258
Cdd:COG1301 135 -AFAE----------GNMLQIIFFAILFGIALAALGEKGKPLLDFFESLSEVMFKIVGWVMKLAPIGVFALIAATVAKYG 203
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668 259 siAATIQSLGWYFITVMIGLFLHGFGTIAVIFFLGTRRLPYRYIAKLSQVLATAFGTGSSSATMPLTIKCL-DNMGIDPR 337
Cdd:COG1301 204 --LDALGSLGKLVLTVYLALLLHLFVVLPLILRLLTGLSPLKFLRAIRPALLLAFSTSSSEATLPVTMEKAeEKLGVSKS 281
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668 338 VTRFVIPVGATINMDGTALYEAVAALFIAQYREMSYSFGTIVAVSITATAASIGAAGIPQAGLVTMVMVLDTVGLEPKDV 417
Cdd:COG1301 282 VASFVLPLGATINMDGTAIYQAVAALFIAQAYGIDLSLGQQLTIVLTAVLASIGAAGVPGAGLVMLAAVLSAVGLPLEGI 361
                       410       420       430
                ....*....|....*....|....*....|.
gi 17137668 418 SLIIAVDWLLDRFRTTINVMCDALGTILVNH 448
Cdd:COG1301 362 ALILGIDRILDMARTAVNVTGDAVATVVVAK 392
 
Name Accession Description Interval E-value
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
20-448 9.98e-111

Na+/H+-dicarboxylate symporter [Energy production and conversion];


Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 333.23  E-value: 9.98e-111
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668  20 LTMATVIGVFVGGLIGFIIKNSTGEWskreimyISFPGEIFLRMLKCLIVPLLVSSITSAIGGL-DLSMSSKIATRAITY 98
Cdd:COG1301   5 LTLQILIALVLGILLGLLLPELVAAV-------LKPLGDIFINLLKMIVVPLVFFSIVVGIASLgDLKKLGRIGGKTLLY 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668  99 YFVTTISAVILGICLVTTLRPGQGAKIVETQTESIDKAskvlTPDTLMDLVRNMFTDNIIQstmfqhrteiyentsispa 178
Cdd:COG1301  78 FLVTTTIALVIGLVVANLFQPGAGLNLDLADAAAAEAA----EAPSLLDFLLNIIPSNIFE------------------- 134
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668 179 qPMENwefksaqregSNVLGLVMFSVILGTTIGRMREKGQLLQDFFTTLSEAMMTITSWVIWISPLGVAFLIAAKIIEME 258
Cdd:COG1301 135 -AFAE----------GNMLQIIFFAILFGIALAALGEKGKPLLDFFESLSEVMFKIVGWVMKLAPIGVFALIAATVAKYG 203
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668 259 siAATIQSLGWYFITVMIGLFLHGFGTIAVIFFLGTRRLPYRYIAKLSQVLATAFGTGSSSATMPLTIKCL-DNMGIDPR 337
Cdd:COG1301 204 --LDALGSLGKLVLTVYLALLLHLFVVLPLILRLLTGLSPLKFLRAIRPALLLAFSTSSSEATLPVTMEKAeEKLGVSKS 281
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668 338 VTRFVIPVGATINMDGTALYEAVAALFIAQYREMSYSFGTIVAVSITATAASIGAAGIPQAGLVTMVMVLDTVGLEPKDV 417
Cdd:COG1301 282 VASFVLPLGATINMDGTAIYQAVAALFIAQAYGIDLSLGQQLTIVLTAVLASIGAAGVPGAGLVMLAAVLSAVGLPLEGI 361
                       410       420       430
                ....*....|....*....|....*....|.
gi 17137668 418 SLIIAVDWLLDRFRTTINVMCDALGTILVNH 448
Cdd:COG1301 362 ALILGIDRILDMARTAVNVTGDAVATVVVAK 392
SDF pfam00375
Sodium:dicarboxylate symporter family;
20-449 9.91e-106

Sodium:dicarboxylate symporter family;


Pssm-ID: 425646 [Multi-domain]  Cd Length: 388  Bit Score: 319.85  E-value: 9.91e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668    20 LTMATVIGVFVGGLIGFIIKNStgewskreIMYISFPGEIFLRMLKCLIVPLLVSSITSAIGGL-DLSMSSKIATRAITY 98
Cdd:pfam00375   1 LLLQILIALVLGILIGLFFPEL--------AAWLKPLGDLFIRLLKMIIVPLIFASIISGIASLgDGKKLGKLGGKTLLY 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668    99 YFVTTISAVILGICLVTTLRPGQGAKIVETQTESIDKASkvltPDTLMDLVRNMFTDNIIQSTMfqhrteiyentsispa 178
Cdd:pfam00375  73 FLVTTAIAALIGLLVANVFQPGSGLALIAASLKEAKAAE----APSLLDFILNIIPSNIFEALA---------------- 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668   179 qpmenwefksaqreGSNVLGLVMFSVILGTTIGRMREKGQLLQDFFTTLSEAMMTITSWVIWISPLGVAFLIAAKIIEme 258
Cdd:pfam00375 133 --------------EGNVLAVIVFAILFGIALAALGEKGEPLLNFIESLQEVMMKVIGWVMKLAPIGVFALIANTVGT-- 196
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668   259 SIAATIQSLGWYFITVMIGLFLHGFGTIAVIFFLGTRRLPYRYIAKLSQVLATAFGTGSSSATMPLTIKCL-DNMGIDPR 337
Cdd:pfam00375 197 YGLGILSSLAKFLLVVYLGLAIHLLIVYPLLIKFLGKVNPFKFLKKMLPALLTAFSTASSAATLPVTLECAeKNLGVSES 276
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668   338 VTRFVIPVGATINMDGTALYEAVAALFIAQYREMSYSFGTIVAVSITATAASIGAAGIPQAGLVTMVMVLDTVGLEPKDV 417
Cdd:pfam00375 277 IASFVLPLGATINMDGTAIYLAVAAIFIAQAYGVDLSFGQQLTLVLTATLASIGAAGVPGGGLVALGLVLSALGLPLEGI 356
                         410       420       430
                  ....*....|....*....|....*....|..
gi 17137668   418 SLIIAVDWLLDRFRTTINVMCDALGTILVNHL 449
Cdd:pfam00375 357 ALILAIDRLLDMFRTAVNVTGDAAAAVIVAKL 388
gltP PRK11283
glutamate/aspartate:proton symporter; Provisional
25-446 3.39e-32

glutamate/aspartate:proton symporter; Provisional


Pssm-ID: 183075 [Multi-domain]  Cd Length: 437  Bit Score: 127.57  E-value: 3.39e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668   25 VIGVFVGGLIGFIIKNSTGEWSKREIMYISFPGEIFLRMLKCLIVPLLVSSITSAIGGL-DLSMSSKIATRAITYYFVTT 103
Cdd:PRK11283  13 LIALVLGILLGAYLHYHSDSRDWLVSNLLSPAGDIFIHLIKMIVVPIVISTLIVGIAGVgDAKQLGRIGAKTIIYFEVIT 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668  104 ISAVILGICLVTTLRPGQGAKIVETQTESIDK----ASKVLTPD-TLMDLVRNMFTDNIIQSTMfqhrteiyentsispa 178
Cdd:PRK11283  93 TVAIILGITLANVFQPGAGIDMSQLATVDISKyqstTEEVQSHShGLMGTILSLIPTNIFASMA---------------- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668  179 qpmenwefksaqreGSNVLGLVMFSVILGTTIGRMREK-GQLLQDFFTTLSEAMMTITSWVIWISPLGVAFLIAAKIIEM 257
Cdd:PRK11283 157 --------------KGEMLPIIFFSVLFGLGLSSLPAThREPLVTVFRSVSETMFKVTHMVMRYAPVGVFALIAVTVANF 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668  258 EsiAATIQSLGWYFITVMIGLFLHGF---GTIAVIFFLGTRRLpyryIAKLSQVLATAFGTGSSSATMPLTIKCLDNMGI 334
Cdd:PRK11283 223 G--FASLWPLAKLVLLVYFAILFFALvvlGIVARLCGLSIWIL----IRILKDELILAYSTASSETVLPRIIEKMEAYGA 296
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668  335 DPRVTRFVIPVGATINMDGTALYEAVAALFIAQYREMSYSFGTIVAVSITATAASIGAAGIPQAGLVTMVMVLDTVGLEP 414
Cdd:PRK11283 297 PKSITSFVVPTGYSFNLDGSTLYQSIAAIFIAQLYGIDLSIWQEIILVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPL 376
                        410       420       430
                 ....*....|....*....|....*....|..
gi 17137668  415 KDVSLIIAVDWLLDRFRTTINVMCDALGTILV 446
Cdd:PRK11283 377 EGLAFIAGVDRILDMARTALNVVGNALAVLVI 408
 
Name Accession Description Interval E-value
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
20-448 9.98e-111

Na+/H+-dicarboxylate symporter [Energy production and conversion];


Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 333.23  E-value: 9.98e-111
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668  20 LTMATVIGVFVGGLIGFIIKNSTGEWskreimyISFPGEIFLRMLKCLIVPLLVSSITSAIGGL-DLSMSSKIATRAITY 98
Cdd:COG1301   5 LTLQILIALVLGILLGLLLPELVAAV-------LKPLGDIFINLLKMIVVPLVFFSIVVGIASLgDLKKLGRIGGKTLLY 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668  99 YFVTTISAVILGICLVTTLRPGQGAKIVETQTESIDKAskvlTPDTLMDLVRNMFTDNIIQstmfqhrteiyentsispa 178
Cdd:COG1301  78 FLVTTTIALVIGLVVANLFQPGAGLNLDLADAAAAEAA----EAPSLLDFLLNIIPSNIFE------------------- 134
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668 179 qPMENwefksaqregSNVLGLVMFSVILGTTIGRMREKGQLLQDFFTTLSEAMMTITSWVIWISPLGVAFLIAAKIIEME 258
Cdd:COG1301 135 -AFAE----------GNMLQIIFFAILFGIALAALGEKGKPLLDFFESLSEVMFKIVGWVMKLAPIGVFALIAATVAKYG 203
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668 259 siAATIQSLGWYFITVMIGLFLHGFGTIAVIFFLGTRRLPYRYIAKLSQVLATAFGTGSSSATMPLTIKCL-DNMGIDPR 337
Cdd:COG1301 204 --LDALGSLGKLVLTVYLALLLHLFVVLPLILRLLTGLSPLKFLRAIRPALLLAFSTSSSEATLPVTMEKAeEKLGVSKS 281
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668 338 VTRFVIPVGATINMDGTALYEAVAALFIAQYREMSYSFGTIVAVSITATAASIGAAGIPQAGLVTMVMVLDTVGLEPKDV 417
Cdd:COG1301 282 VASFVLPLGATINMDGTAIYQAVAALFIAQAYGIDLSLGQQLTIVLTAVLASIGAAGVPGAGLVMLAAVLSAVGLPLEGI 361
                       410       420       430
                ....*....|....*....|....*....|.
gi 17137668 418 SLIIAVDWLLDRFRTTINVMCDALGTILVNH 448
Cdd:COG1301 362 ALILGIDRILDMARTAVNVTGDAVATVVVAK 392
SDF pfam00375
Sodium:dicarboxylate symporter family;
20-449 9.91e-106

Sodium:dicarboxylate symporter family;


Pssm-ID: 425646 [Multi-domain]  Cd Length: 388  Bit Score: 319.85  E-value: 9.91e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668    20 LTMATVIGVFVGGLIGFIIKNStgewskreIMYISFPGEIFLRMLKCLIVPLLVSSITSAIGGL-DLSMSSKIATRAITY 98
Cdd:pfam00375   1 LLLQILIALVLGILIGLFFPEL--------AAWLKPLGDLFIRLLKMIIVPLIFASIISGIASLgDGKKLGKLGGKTLLY 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668    99 YFVTTISAVILGICLVTTLRPGQGAKIVETQTESIDKASkvltPDTLMDLVRNMFTDNIIQSTMfqhrteiyentsispa 178
Cdd:pfam00375  73 FLVTTAIAALIGLLVANVFQPGSGLALIAASLKEAKAAE----APSLLDFILNIIPSNIFEALA---------------- 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668   179 qpmenwefksaqreGSNVLGLVMFSVILGTTIGRMREKGQLLQDFFTTLSEAMMTITSWVIWISPLGVAFLIAAKIIEme 258
Cdd:pfam00375 133 --------------EGNVLAVIVFAILFGIALAALGEKGEPLLNFIESLQEVMMKVIGWVMKLAPIGVFALIANTVGT-- 196
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668   259 SIAATIQSLGWYFITVMIGLFLHGFGTIAVIFFLGTRRLPYRYIAKLSQVLATAFGTGSSSATMPLTIKCL-DNMGIDPR 337
Cdd:pfam00375 197 YGLGILSSLAKFLLVVYLGLAIHLLIVYPLLIKFLGKVNPFKFLKKMLPALLTAFSTASSAATLPVTLECAeKNLGVSES 276
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668   338 VTRFVIPVGATINMDGTALYEAVAALFIAQYREMSYSFGTIVAVSITATAASIGAAGIPQAGLVTMVMVLDTVGLEPKDV 417
Cdd:pfam00375 277 IASFVLPLGATINMDGTAIYLAVAAIFIAQAYGVDLSFGQQLTLVLTATLASIGAAGVPGGGLVALGLVLSALGLPLEGI 356
                         410       420       430
                  ....*....|....*....|....*....|..
gi 17137668   418 SLIIAVDWLLDRFRTTINVMCDALGTILVNHL 449
Cdd:pfam00375 357 ALILAIDRLLDMFRTAVNVTGDAAAAVIVAKL 388
gltP PRK11283
glutamate/aspartate:proton symporter; Provisional
25-446 3.39e-32

glutamate/aspartate:proton symporter; Provisional


Pssm-ID: 183075 [Multi-domain]  Cd Length: 437  Bit Score: 127.57  E-value: 3.39e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668   25 VIGVFVGGLIGFIIKNSTGEWSKREIMYISFPGEIFLRMLKCLIVPLLVSSITSAIGGL-DLSMSSKIATRAITYYFVTT 103
Cdd:PRK11283  13 LIALVLGILLGAYLHYHSDSRDWLVSNLLSPAGDIFIHLIKMIVVPIVISTLIVGIAGVgDAKQLGRIGAKTIIYFEVIT 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668  104 ISAVILGICLVTTLRPGQGAKIVETQTESIDK----ASKVLTPD-TLMDLVRNMFTDNIIQSTMfqhrteiyentsispa 178
Cdd:PRK11283  93 TVAIILGITLANVFQPGAGIDMSQLATVDISKyqstTEEVQSHShGLMGTILSLIPTNIFASMA---------------- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668  179 qpmenwefksaqreGSNVLGLVMFSVILGTTIGRMREK-GQLLQDFFTTLSEAMMTITSWVIWISPLGVAFLIAAKIIEM 257
Cdd:PRK11283 157 --------------KGEMLPIIFFSVLFGLGLSSLPAThREPLVTVFRSVSETMFKVTHMVMRYAPVGVFALIAVTVANF 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668  258 EsiAATIQSLGWYFITVMIGLFLHGF---GTIAVIFFLGTRRLpyryIAKLSQVLATAFGTGSSSATMPLTIKCLDNMGI 334
Cdd:PRK11283 223 G--FASLWPLAKLVLLVYFAILFFALvvlGIVARLCGLSIWIL----IRILKDELILAYSTASSETVLPRIIEKMEAYGA 296
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668  335 DPRVTRFVIPVGATINMDGTALYEAVAALFIAQYREMSYSFGTIVAVSITATAASIGAAGIPQAGLVTMVMVLDTVGLEP 414
Cdd:PRK11283 297 PKSITSFVVPTGYSFNLDGSTLYQSIAAIFIAQLYGIDLSIWQEIILVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPL 376
                        410       420       430
                 ....*....|....*....|....*....|..
gi 17137668  415 KDVSLIIAVDWLLDRFRTTINVMCDALGTILV 446
Cdd:PRK11283 377 EGLAFIAGVDRILDMARTALNVVGNALAVLVI 408
PRK13027 PRK13027
C4-dicarboxylate transporter DctA; Reviewed
57-446 1.33e-31

C4-dicarboxylate transporter DctA; Reviewed


Pssm-ID: 183850 [Multi-domain]  Cd Length: 421  Bit Score: 125.55  E-value: 1.33e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668   57 GEIFLRMLKCLIVPLLVSSITSAIGGL-DLSMSSKIATRAITYYFVTTISAVILGICLVTTLRPGQGAKIVETQTESIDK 135
Cdd:PRK13027  37 GDGFIKLIKMLIGPIVFCVVVSGIAGAgDLKKVGRVGLKAVIYFEVMTTIALVIGLVLAYLTGPGVGMNIDLRSLDAASL 116
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668  136 ASKVLTPDTLMDLVRnmFTDNIIQSTMFqhrteiyentsispaqpmenwefkSAQREGsNVLGLVMFSVILGTTIGRMRE 215
Cdd:PRK13027 117 AGYAKNAQSLKGTAG--FLLKLIPTTAV------------------------DAFAKG-DILQVLLFSVLFGSALSLLGE 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668  216 KGQLLQDFFTTLSEAMMTITSWVIWISPLGVAFLIAAKIIEMEsiAATIQSLGWYFITVMIGLFLHGFGTIAVIFFLGTR 295
Cdd:PRK13027 170 RAKRVNRLIDELSHVLFRIMGFIIKLAPLGVLGAIAFTTGKYG--VGSLKQLGMLVAVFYLTCFVFVVVVLGAVMRLAGF 247
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668  296 RLpYRYIAKLSQVLATAFGTGSSSATMPLTIKCLDNMGIDPRVTRFVIPVGATINMDGTALYEAVAALFIAQYREMSYSF 375
Cdd:PRK13027 248 SV-FKLIRYLREELLIVLGTASSDAVLPQVMRKLEHMGIKDSTVGLVIPTGYSFNLDGFSIYLTLAAVFIAQATNTPLSM 326
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17137668  376 GTIVAVSITATAASIGAAGIPQAGLVTMVMVLDTVGLEPK-DVSLIIAVDWLLDRFRTTINVMCDALGTILV 446
Cdd:PRK13027 327 HDLITILLVSLVTSKGAHGIPGSAIVILAATLSAIPAIPVlGLVLILPVDWFMGIARALTNLIGNCVATVVV 398
PRK01663 PRK01663
C4-dicarboxylate transporter DctA; Reviewed
57-446 4.77e-30

C4-dicarboxylate transporter DctA; Reviewed


Pssm-ID: 234968 [Multi-domain]  Cd Length: 428  Bit Score: 121.55  E-value: 4.77e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668   57 GEIFLRMLKCLIVPLLVSSITSAIGGL-DLSMSSKIATRAITYYFVTTISAVILGICLVTTLRPGQG---------AKIV 126
Cdd:PRK01663  38 GDGFIKLIKMIIAPIIFCTVVTGIAGMgDMKKVGRVGGKALLYFEIVSTIALIIGLIVVNVVQPGAGmnidpatldAKAV 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668  127 ETQTEsidKASKVLTPDTLMdlvrnmftdNIIQSTMFqhrteiyentsispaqpmenwefkSAQREGsNVLGLVMFSVIL 206
Cdd:PRK01663 118 AQYAA---QAHEQGTVDFLM---------DIIPTTVV------------------------GAFASG-DILQVLLFAVLF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668  207 GTTIGRMREKGQLLQDFFTTLSEAMMTITSWVIWISPLGV----AFLIAAKIIemesiaATIQSLGWYFITVMIGLFLHG 282
Cdd:PRK01663 161 GFALARLGEKGKPVFDFIESLSHVLFGIVNMIMKLAPIGAfgamAFTIGKYGV------GSLVQLGQLIGCFYITCILFV 234
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668  283 FGTIAVIFFLGTRRLpYRYIAKLSQVLATAFGTGSSSATMPLTIKCLDNMGIDPRVTRFVIPVGATINMDGTALYEAVAA 362
Cdd:PRK01663 235 FVVLGAIARLTGFSI-FKFIRYIKEELLIVLGTSSSESALPRMMEKMEKLGCKKSVVGLVIPTGYSFNLDGTSIYLTMAA 313
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668  363 LFIAQYREMSYSFGTIVAVSITATAASIGAAGIPQAGLVTMVMVLDTVGLEP-KDVSLIIAVDWLLDRFRTTINVMCDAL 441
Cdd:PRK01663 314 VFIAQATNTPLSIGHQITLLAVLLLTSKGAAGVTGSGFIVLAATLSAVPHIPvAGLALILGIDRFMSEARALTNLIGNGV 393

                 ....*
gi 17137668  442 GTILV 446
Cdd:PRK01663 394 ATVVV 398
PRK14695 PRK14695
serine/threonine transporter SstT; Provisional
194-448 1.05e-14

serine/threonine transporter SstT; Provisional


Pssm-ID: 173158  Cd Length: 319  Bit Score: 75.09  E-value: 1.05e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668  194 SNVLGLVMFSVILGTTigrMREKGQLLQDFFTTLSEAMMTITSWVIWISPLGVAFLIAAKIieMESIAATIQSLGWYFIT 273
Cdd:PRK14695  59 ANYIGILSWAVIFGIA---MREASKNSKELLKTIADVTSKIVEWIINLAPFGILGLVFKTI--SDKGVGSLANYGILLVL 133
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668  274 VMIGLFLHGFGTIAVIFFLGTRRLPYRYIAKLSQVLA-TAFGTGSSSATMPLTIKCLDNMGIDPRVTRFVIPVGATINMD 352
Cdd:PRK14695 134 LVTTMLFVAPVVNPLIAFFFMRRNPYPLVWNCLRVSGvTAFFTRSSATNIPVNMKLCHDLGLNPDTYSVSIPLGSTINMA 213
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668  353 GTALYEAVAALFIAQYREMSYSFGTIVAVSITATAASIGAAGIPQAGLVTMVMVLDTVGLEPKDVSLIIAVDWLL----D 428
Cdd:PRK14695 214 GVAITINLLTLVTVNTLGIPVDFATAFVLSVVAAISACGASGIAGGSLLLIPVACSLFGISNDIAIQIVGVGFVIgviqD 293
                        250       260
                 ....*....|....*....|
gi 17137668  429 RFRTTINVMCDALGTILVNH 448
Cdd:PRK14695 294 SCETALNSSTDVLFTAVAEY 313
PRK13628 PRK13628
serine/threonine transporter SstT; Provisional
25-395 1.14e-14

serine/threonine transporter SstT; Provisional


Pssm-ID: 184190 [Multi-domain]  Cd Length: 402  Bit Score: 75.67  E-value: 1.14e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668   25 VIGVFVGGLIGFIIKNSTGewskreimYISFPGEIFLRMLKClIVPLLVSS-ITSAIGGLDLSMSSKIATRAITYYFVT- 102
Cdd:PRK13628  21 LIGLVLGILLALLSPPAAE--------AVGLLGTLFVGALKA-VAPILVFVlVMASIANHKKGQKTNIRPILVLYLLGTf 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668  103 --TISAVILGICLVTTLrpgqgakIVETQTESIDKASKVLtpDTLMDLVRNMFtDNIIQSTMfqhrteiyentsispaqp 180
Cdd:PRK13628  92 laALVAVVASFLFPSTL-------VLVASAADISPPQGIV--EVLKTLLLSLV-DNPINALL------------------ 143
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668  181 menwefksaqreGSNVLGLVMFSVILGTTigrMREKGQLLQDFFTTLSEAMMTITSWVIWISPLGVAFLIAakiiemESI 260
Cdd:PRK13628 144 ------------NANYIGILAWAIGLGLA---LRHASDTTKNVVNDLSEAVSQIVKWVIRFAPIGIFGLVA------STL 202
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668  261 AAT-IQSLGWY--FITVMIG-LFLHGFGTIAVIFFLGTRRLPYRYIAK-LSQVLATAFGTGSSSATMPLTIKCLDNMGID 335
Cdd:PRK13628 203 AETgFSALAGYaqLLAVLVGcMLFVALVVNPLIVFWKIRRNPYPLVFTcLRESGVTAFFTRSSAANIPVNMALCEKLGLD 282
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668  336 PRVTRFVIPVGATINMDGTALYEAVAALFIAQYREMSYSFGTIVAVSITATAASIGAAGI 395
Cdd:PRK13628 283 EDTYSVSIPLGATINMAGAAITITVLTLAAVHTLGIPVDLPTALLLSVVAAISACGASGV 342
SstT COG3633
Na+/serine and Na+/threonine symporter SstT [Amino acid transport and metabolism];
25-396 3.42e-14

Na+/serine and Na+/threonine symporter SstT [Amino acid transport and metabolism];


Pssm-ID: 442850  Cd Length: 406  Bit Score: 74.05  E-value: 3.42e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668  25 VIGVFVGGLIGFIIKNSTgewskreiMYISFPGEIFLRMLKClIVPLLV-----SSITSAIGGLDLSMSSkiatrAITYY 99
Cdd:COG3633  20 LIGLVLGILLALLSPEAA--------KSVGLLGTLFVGALKA-VAPILVfvlvmSAIANHKQGQKTNMKP-----IIVLY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668 100 FVTTISAVILGIcLVTTLRPgqgakivetQTESIDKASKVLTP-----DTLMDLVRNMFtDNIIQSTMfqhrteiyents 174
Cdd:COG3633  86 LLGTFLAALVAV-VASFLFP---------TTLTLVAAAADLTPpggigEVLKTLLLNVV-DNPVNALA------------ 142
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668 175 ispaqpmenwefksaqreGSNVLGLVMFSVILGTTigrMREKGQLLQDFFTTLSEAMMTITSWVIWISPLGVAFLIAaki 254
Cdd:COG3633 143 ------------------NANYIGILAWAIGLGLA---LRHASDTTKTVLSDLSDAVSKIVRWVIRFAPLGIFGLVA--- 198
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668 255 iemESIAAT-IQSLGWYF--ITVMIGLFLhgfgTIA-----VIFFLGTRRLPYRYIAK-LSQVLATAFGTGSSSATMPLT 325
Cdd:COG3633 199 ---STVATTgFSALLGYAhlLAVLVGCML----FVAlvvnpLIVFLKIRRNPYPLVFTcLRESGITAFFTRSSAANIPVN 271
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17137668 326 IKCLDNMGIDPRVTRFVIPVGATINMDGTALYEAVAALFIAQYREMSYSFGTIVAVSITATAASIGAAGIP 396
Cdd:COG3633 272 MALCEKLGLDEDTYSVSIPLGATINMAGAAITITVLTLAAVHTLGIEVDLPTALLLSVVAAVSACGASGVA 342
TcyP COG1823
L-cystine transporter TcyP, sodium:dicarboxylate symporter family [Amino acid transport and ...
26-421 2.37e-10

L-cystine transporter TcyP, sodium:dicarboxylate symporter family [Amino acid transport and metabolism];


Pssm-ID: 441428  Cd Length: 463  Bit Score: 62.54  E-value: 2.37e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668  26 IGVFVGGLIGFIIKNSTGEWS---KREIMYISFPGEIFLRMLKCLIVPLLVSSITSAIGGLDLSMS-SKIATRAITYYFV 101
Cdd:COG1823  36 TGLGLGILFGLILQLIYGAGSpviKQSIDWFNIVGNGYVRLLQMIVMPLVFVSILSAITKLKNASSlGKISGLIIGILLG 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668 102 TTISAVILGIcLVTTLRPGQGAKIVETQTEsidkaskvltpdtlmdlvrnmftdnIIQSTMFQHRTEIYENTSIS----- 176
Cdd:COG1823 116 TTAIAALVGI-LVALLFGLTAEGLTQGAAE-------------------------TARGEALEERLGEVEDLSLPqqils 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668 177 --PAQPMENWefkSAQREGSnVLGLVMFSVILGTTIGRMR----EKGQLLQDFFTTLSEAMMTITSWVIWISPLGVAFLI 250
Cdd:COG1823 170 fiPTNPFADL---TGARPTS-TIAVVIFAAFLGIAALGLRrkkpEQAETFLKGIDALQAIVMRLVRLVLRLTPYGVLALM 245
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668 251 AaKIIEMESIAAtIQSLGWYFITVMIGLFL----HGfgtiavIFFLGTRRLPYRYIAKLSQVLATAFGTGSSSATMPLTI 326
Cdd:COG1823 246 T-KVVATSDFAD-ILNLGKFVVASYVALIImfivHL------LLLALAGLNPLTYFKKVWPVLTFAFTSRSSAGTIPLNI 317
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137668 327 KCL-DNMGIDprvtrfvipvgatinmdgtalyEAVAalfiaqyrEMSYSFGtivavsitataASIG---AAGIPQAGLVt 402
Cdd:COG1823 318 ETQtKRLGVP----------------------EGIA--------NFAASFG-----------ATIGqngCAGIYPAMLA- 355
                       410
                ....*....|....*....
gi 17137668 403 mVMVLDTVGLEPKDVSLII 421
Cdd:COG1823 356 -VMIAPTVGINPLDPSFIL 373
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH