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Conserved domains on  [gi|17137686|ref|NP_477438|]
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tehao, isoform A [Drosophila melanogaster]

Protein Classification

toll-like receptor( domain architecture ID 11471630)

toll-like receptor (TLR) is involved in the recognition of microbial pathogens by the innate immune system, which recognize different pathogen-associated molecular patterns

CATH:  3.40.50.10140|3.80.10.10
Gene Ontology:  GO:0005515|GO:0002224|GO:0006955|GO:0004888|GO:0038187
PubMed:  18227810|16675322|34199501|16822173|11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
643-779 2.69e-27

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 107.79  E-value: 2.69e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686    643 TYDAFISYSHKD---EELISKLLPKLEsgphPFRLCLHDRDWLVGDCIPEQIVRTVDDSKRVIIVLSQHFIDSVWARMEF 719
Cdd:smart00255   1 EYDVFISYSGKEdvrNEFLSHLLEKLR----GYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDEL 76

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17137686    720 RIAYQATLQDKRKRIIIILYREL-EHMNGIDSELRAYLKLNtYLKWGDPL---FWSKLYYAMPH 779
Cdd:smart00255  77 VAALENALEEGGLRVIPIFYEVIpSDVRKQPGKFRKVFKKN-YLKWPEDEkeqFWKKALYAVPS 139
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
184-541 2.16e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.21  E-value: 2.16e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686 184 TLRDLHLSVNVTTLPGNMLSTVNGTLKTLTIESPGIVSFGNPLLRELQQLRNLSLALIHPFHERDKQLQPHFFGSMTNLE 263
Cdd:COG4886  20 LLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLT 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686 264 EVRLasatsSVNRSMFKGTNkLQLIKMNGNDdLMELPGEIFlDQVNLKTLDLSCNAIVTLHEDvFKGLGNLTLLDLSKNR 343
Cdd:COG4886 100 ELDL-----SGNEELSNLTN-LESLDLSGNQ-LTDLPEELA-NLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQ 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686 344 LTNLSSTIfAPLTSLNVLRLNKNSLTAMsPSVFQDVVSLNYIemvntqfygatllmnyeavvctndeacqyksaewqcdp 423
Cdd:COG4886 171 LTDLPEEL-GNLTNLKELDLSNNQITDL-PEPLGNLTNLEEL-------------------------------------- 210

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686 424 rcicwvqrsvgslivDCRGTSLEELPD-LPRTTLLsTVLKVGNNSLTSLPTVSEHSgyaNVSGLFLSDNNLTSLGSGDQL 502
Cdd:COG4886 211 ---------------DLSGNQLTDLPEpLANLTNL-ETLDLSNNQLTDLPELGNLT---NLEELDLSNNQLTDLPPLANL 271

                       330       340       350
                ....*....|....*....|....*....|....*....
gi 17137686 503 PdNLTHLDVRGNQIQSLSDEFLLFLQEPNNTMTLSLSGN 541
Cdd:COG4886 272 T-NLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLN 309
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
643-779 2.69e-27

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 107.79  E-value: 2.69e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686    643 TYDAFISYSHKD---EELISKLLPKLEsgphPFRLCLHDRDWLVGDCIPEQIVRTVDDSKRVIIVLSQHFIDSVWARMEF 719
Cdd:smart00255   1 EYDVFISYSGKEdvrNEFLSHLLEKLR----GYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDEL 76

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17137686    720 RIAYQATLQDKRKRIIIILYREL-EHMNGIDSELRAYLKLNtYLKWGDPL---FWSKLYYAMPH 779
Cdd:smart00255  77 VAALENALEEGGLRVIPIFYEVIpSDVRKQPGKFRKVFKKN-YLKWPEDEkeqFWKKALYAVPS 139
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 647-749 1.31e-19

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 85.06  E-value: 1.31e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686   647 FISYSHKDEELISKLLPKLESgpHPFRLCLHDRDWLVGDCIPEQIVRTVDDSKRVIIVLSQHFIDSVWARMEFRIAYQAt 726
Cdd:pfam13676   2 FISYAGEDRAWAEWLADALEA--AGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAALAD- 78

                          90       100
                  ....*....|....*....|....*....
gi 17137686   727 lQDKRKRIIIILYR------ELEHMNGID 749
Cdd:pfam13676  79 -PEGRKRLIPVRLEcdlelpGLAGLQYID 106
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
184-541 2.16e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.21  E-value: 2.16e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686 184 TLRDLHLSVNVTTLPGNMLSTVNGTLKTLTIESPGIVSFGNPLLRELQQLRNLSLALIHPFHERDKQLQPHFFGSMTNLE 263
Cdd:COG4886  20 LLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLT 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686 264 EVRLasatsSVNRSMFKGTNkLQLIKMNGNDdLMELPGEIFlDQVNLKTLDLSCNAIVTLHEDvFKGLGNLTLLDLSKNR 343
Cdd:COG4886 100 ELDL-----SGNEELSNLTN-LESLDLSGNQ-LTDLPEELA-NLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQ 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686 344 LTNLSSTIfAPLTSLNVLRLNKNSLTAMsPSVFQDVVSLNYIemvntqfygatllmnyeavvctndeacqyksaewqcdp 423
Cdd:COG4886 171 LTDLPEEL-GNLTNLKELDLSNNQITDL-PEPLGNLTNLEEL-------------------------------------- 210

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686 424 rcicwvqrsvgslivDCRGTSLEELPD-LPRTTLLsTVLKVGNNSLTSLPTVSEHSgyaNVSGLFLSDNNLTSLGSGDQL 502
Cdd:COG4886 211 ---------------DLSGNQLTDLPEpLANLTNL-ETLDLSNNQLTDLPELGNLT---NLEELDLSNNQLTDLPPLANL 271

                       330       340       350
                ....*....|....*....|....*....|....*....
gi 17137686 503 PdNLTHLDVRGNQIQSLSDEFLLFLQEPNNTMTLSLSGN 541
Cdd:COG4886 272 T-NLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLN 309
LRR_8 pfam13855
Leucine rich repeat;
309-368 4.54e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.69  E-value: 4.54e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686   309 NLKTLDLSCNAIVTLHEDVFKGLGNLTLLDLSKNRLTNLSSTIFAPLTSLNVLRLNKNSL 368
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
312-550 8.33e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 49.31  E-value: 8.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686  312 TLDLSCNAIVTLHEDVFkglGNLTLLDLSKNRLTNLSSTIfaPLTsLNVLRLNKNSLTAMS---PSVFQdvvslnyiemv 388
Cdd:PRK15370 203 TLILDNNELKSLPENLQ---GNIKTLYANSNQLTSIPATL--PDT-IQEMELSINRITELPerlPSALQ----------- 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686  389 ntqfygaTLLMNYEAVVCTND---EACQYksaewqcdprcicwvqrsvgsliVDCRGTSLEELPD-LPRTTllsTVLKVG 464
Cdd:PRK15370 266 -------SLDLFHNKISCLPEnlpEELRY-----------------------LSVYDNSIRTLPAhLPSGI---THLNVQ 312

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686  465 NNSLTSLPTVSEhsgyANVSGLFLSDNNLTSLGSgdQLPDNLTHLDVRGNQIQSLSDEFllflqePNNTMTLSLSGNPIT 544
Cdd:PRK15370 313 SNSLTALPETLP----PGLKTLEAGENALTSLPA--SLPPELQVLDVSKNQITVLPETL------PPTITTLDVSRNALT 380


                 ....*.
gi 17137686  545 CGCESL 550
Cdd:PRK15370 381 NLPENL 386
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 488-544 3.57e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 3.57e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 17137686 488 LSDNNLTSLGSGDQLpDNLTHLDVRGNQIQSLSDEFLLFLQEPNNTmTLSLSGNPIT 544
Cdd:cd21340 127 ISGNNIDSLEPLAPL-RNLEQLDASNNQISDLEELLDLLSSWPSLR-ELDLTGNPVC 181
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
643-779 2.69e-27

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 107.79  E-value: 2.69e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686    643 TYDAFISYSHKD---EELISKLLPKLEsgphPFRLCLHDRDWLVGDCIPEQIVRTVDDSKRVIIVLSQHFIDSVWARMEF 719
Cdd:smart00255   1 EYDVFISYSGKEdvrNEFLSHLLEKLR----GYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDEL 76

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17137686    720 RIAYQATLQDKRKRIIIILYREL-EHMNGIDSELRAYLKLNtYLKWGDPL---FWSKLYYAMPH 779
Cdd:smart00255  77 VAALENALEEGGLRVIPIFYEVIpSDVRKQPGKFRKVFKKN-YLKWPEDEkeqFWKKALYAVPS 139
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 647-749 1.31e-19

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 85.06  E-value: 1.31e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686   647 FISYSHKDEELISKLLPKLESgpHPFRLCLHDRDWLVGDCIPEQIVRTVDDSKRVIIVLSQHFIDSVWARMEFRIAYQAt 726
Cdd:pfam13676   2 FISYAGEDRAWAEWLADALEA--AGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAALAD- 78

                          90       100
                  ....*....|....*....|....*....
gi 17137686   727 lQDKRKRIIIILYR------ELEHMNGID 749
Cdd:pfam13676  79 -PEGRKRLIPVRLEcdlelpGLAGLQYID 106
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
184-541 2.16e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.21  E-value: 2.16e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686 184 TLRDLHLSVNVTTLPGNMLSTVNGTLKTLTIESPGIVSFGNPLLRELQQLRNLSLALIHPFHERDKQLQPHFFGSMTNLE 263
Cdd:COG4886  20 LLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLT 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686 264 EVRLasatsSVNRSMFKGTNkLQLIKMNGNDdLMELPGEIFlDQVNLKTLDLSCNAIVTLHEDvFKGLGNLTLLDLSKNR 343
Cdd:COG4886 100 ELDL-----SGNEELSNLTN-LESLDLSGNQ-LTDLPEELA-NLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQ 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686 344 LTNLSSTIfAPLTSLNVLRLNKNSLTAMsPSVFQDVVSLNYIemvntqfygatllmnyeavvctndeacqyksaewqcdp 423
Cdd:COG4886 171 LTDLPEEL-GNLTNLKELDLSNNQITDL-PEPLGNLTNLEEL-------------------------------------- 210

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686 424 rcicwvqrsvgslivDCRGTSLEELPD-LPRTTLLsTVLKVGNNSLTSLPTVSEHSgyaNVSGLFLSDNNLTSLGSGDQL 502
Cdd:COG4886 211 ---------------DLSGNQLTDLPEpLANLTNL-ETLDLSNNQLTDLPELGNLT---NLEELDLSNNQLTDLPPLANL 271

                       330       340       350
                ....*....|....*....|....*....|....*....
gi 17137686 503 PdNLTHLDVRGNQIQSLSDEFLLFLQEPNNTMTLSLSGN 541
Cdd:COG4886 272 T-NLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLN 309
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 644-777 5.46e-12

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 64.69  E-value: 5.46e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686   644 YDAFISYSHKDEE--LISKLLPKLesGPHPFRLCLHDRDWLVGDCIPEQIVRTVDDSKRVIIVLSQHFIDSVWARMEFRI 721
Cdd:pfam01582   1 YDVFLSFRGSDTRewFVSHLLKEL--KQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVK 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686   722 AYQATLQDKRKrIIIILYREL-EHMNGIDSEL-------RAYLKLNTYLKW-----------------GDPLFWSKLYYA 776
Cdd:pfam01582  79 ILECALDLGQK-VIPIFYEVDpSDVRKQTGSFgkafkkhKKVLTEEKVLKWrgalnevaniwhsksvsDESKFWKKIAYD 157


                  .
gi 17137686   777 M 777
Cdd:pfam01582 158 I 158
LRR_8 pfam13855
Leucine rich repeat;
309-368 4.54e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.69  E-value: 4.54e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686   309 NLKTLDLSCNAIVTLHEDVFKGLGNLTLLDLSKNRLTNLSSTIFAPLTSLNVLRLNKNSL 368
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
179-397 1.35e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.10  E-value: 1.35e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686 179 FHGFDTLRDLHLSVN-VTTLPGNMLSTVNgtLKTLTIESPGIVSFGNPLlRELQQLRNLSLalihpfheRDKQLQ--PHF 255
Cdd:COG4886 109 LSNLTNLESLDLSGNqLTDLPEELANLTN--LKELDLSNNQLTDLPEPL-GNLTNLKSLDL--------SNNQLTdlPEE 177

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686 256 FGSMTNLEEVRLASatssvnrsmfkgtNKLQLIKmngnDDLMELPgeifldqvNLKTLDLSCNAIVTLhEDVFKGLGNLT 335
Cdd:COG4886 178 LGNLTNLKELDLSN-------------NQITDLP----EPLGNLT--------NLEELDLSGNQLTDL-PEPLANLTNLE 231

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17137686 336 LLDLSKNRLTNLSStiFAPLTSLNVLRLNKNSLTAMSPSvfQDVVSLNYIEMVNTQFYGATL 397
Cdd:COG4886 232 TLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQLTDLKL 289
LRR_8 pfam13855
Leucine rich repeat;
333-392 3.80e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.60  E-value: 3.80e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686   333 NLTLLDLSKNRLTNLSSTIFAPLTSLNVLRLNKNSLTAMSPSVFQDVVSLNYIEMVNTQF 392
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
261-544 6.93e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.71  E-value: 6.93e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686 261 NLEEVRLASATSSVNRSMFKGTNKLQLIKMNGNDDLMELPGEIFLDQV-NLKTLDLSCNaivtlheDVFKGLGNLTLLDL 339
Cdd:COG4886  48 LLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLtNLTELDLSGN-------EELSNLTNLESLDL 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686 340 SKNRLTNLSSTIfAPLTSLNVLRLNKNSLTAMSPSvfqdvvslnyiemvntqfygatllmnyeavvctndeacqyksaew 419
Cdd:COG4886 121 SGNQLTDLPEEL-ANLTNLKELDLSNNQLTDLPEP--------------------------------------------- 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686 420 qcdprcicwvqrsvgslivdcrgtsLEELPDLprttllsTVLKVGNNSLTSLPtvSEHSGYANVSGLFLSDNNLTSLGSG 499
Cdd:COG4886 155 -------------------------LGNLTNL-------KSLDLSNNQLTDLP--EELGNLTNLKELDLSNNQITDLPEP 200

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 17137686 500 -DQLPdNLTHLDVRGNQIQSLSDEfllfLQEPNNTMTLSLSGNPIT 544
Cdd:COG4886 201 lGNLT-NLEELDLSGNQLTDLPEP----LANLTNLETLDLSNNQLT 241
LRR_8 pfam13855
Leucine rich repeat;
299-344 1.44e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.44e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 17137686   299 LPGEIFLDQVNLKTLDLSCNAIVTLHEDVFKGLGNLTLLDLSKNRL 344
Cdd:pfam13855  16 LDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
312-550 8.33e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 49.31  E-value: 8.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686  312 TLDLSCNAIVTLHEDVFkglGNLTLLDLSKNRLTNLSSTIfaPLTsLNVLRLNKNSLTAMS---PSVFQdvvslnyiemv 388
Cdd:PRK15370 203 TLILDNNELKSLPENLQ---GNIKTLYANSNQLTSIPATL--PDT-IQEMELSINRITELPerlPSALQ----------- 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686  389 ntqfygaTLLMNYEAVVCTND---EACQYksaewqcdprcicwvqrsvgsliVDCRGTSLEELPD-LPRTTllsTVLKVG 464
Cdd:PRK15370 266 -------SLDLFHNKISCLPEnlpEELRY-----------------------LSVYDNSIRTLPAhLPSGI---THLNVQ 312

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686  465 NNSLTSLPTVSEhsgyANVSGLFLSDNNLTSLGSgdQLPDNLTHLDVRGNQIQSLSDEFllflqePNNTMTLSLSGNPIT 544
Cdd:PRK15370 313 SNSLTALPETLP----PGLKTLEAGENALTSLPA--SLPPELQVLDVSKNQITVLPETL------PPTITTLDVSRNALT 380


                 ....*.
gi 17137686  545 CGCESL 550
Cdd:PRK15370 381 NLPENL 386
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
458-544 2.90e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 47.85  E-value: 2.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686  458 STVLKVGNNSLTSLPTVSEhsgyANVSGLFLSDNNLTSLGSgdqLPDNLTHLDVRGNQIQSLSdefllflQEPNNTMTLS 537
Cdd:PRK15387 203 NAVLNVGESGLTTLPDCLP----AHITTLVIPDNNLTSLPA---LPPELRTLEVSGNQLTSLP-------VLPPGLLELS 268


                 ....*..
gi 17137686  538 LSGNPIT 544
Cdd:PRK15387 269 IFSNPLT 275
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
173-402 1.46e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.92  E-value: 1.46e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686 173 ELQESIFhGFDTLRDLHLSVN-VTTLPGNMLSTVNgtLKTLTIESPGIVSFGNPLlRELQQLRNLSLAlihpfherDKQL 251
Cdd:COG4886 150 DLPEPLG-NLTNLKSLDLSNNqLTDLPEELGNLTN--LKELDLSNNQITDLPEPL-GNLTNLEELDLS--------GNQL 217

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686 252 Q--PHFFGSMTNLEEVRLaSATSSVNRSMFKGTNKLQLIKMNGNDdLMELPGEIFLDqvNLKTLDLSCNAIVTLHEDVFK 329
Cdd:COG4886 218 TdlPEPLANLTNLETLDL-SNNQLTDLPELGNLTNLEELDLSNNQ-LTDLPPLANLT--NLKTLDLSNNQLTDLKLKELE 293

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17137686 330 GLGNLTLLDLSKNRLTNLSSTIFAPLTSLNVLRLNKNSLTAMSPSVFQDVVSLNYIEMVNTQFYGATLLMNYE 402
Cdd:COG4886 294 LLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLL 366
PLN03150 PLN03150
hypothetical protein; Provisional
 310-374 1.32e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.11  E-value: 1.32e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17137686  310 LKTLDLSCNAIvtlHEDVFKGLGN---LTLLDLSKNRLTNLSSTIFAPLTSLNVLRLNKNSLTAMSPS 374
Cdd:PLN03150 444 LQSINLSGNSI---RGNIPPSLGSitsLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPA 508
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 488-544 3.57e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 3.57e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 17137686 488 LSDNNLTSLGSGDQLpDNLTHLDVRGNQIQSLSDEFLLFLQEPNNTmTLSLSGNPIT 544
Cdd:cd21340 127 ISGNNIDSLEPLAPL-RNLEQLDASNNQISDLEELLDLLSSWPSLR-ELDLTGNPVC 181
LRR_8 pfam13855
Leucine rich repeat;
459-516 4.52e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 4.52e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17137686   459 TVLKVGNNSLTSLPTVSEHSGYaNVSGLFLSDNNLTSL--GSGDQLPdNLTHLDVRGNQI 516
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLS-NLKVLDLSNNLLTTLspGAFSGLP-SLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 310-372 5.32e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 5.32e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17137686 310 LKTLDLSCNAIVTLHEdvFKGLGNLTLLDLSKNRLTNLS--STIFAPLTSLNVLRLNKNSLTAMS 372
Cdd:cd21340 122 LRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPVCKKP 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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