|
Name |
Accession |
Description |
Interval |
E-value |
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
35-791 |
0e+00 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 975.30 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 35 GLVHIRLEPDIRkAFSPDDSDAGYETRVWLEYYGLDIYPERAFCIFTAKRENSSILQEGALADIYTVDNRLSAAVGYQDG 114
Cdd:pfam02460 5 DIVYTRTPDDAR-SFTERGVRSEYEPLVENKFFPGDSYPEARFLIITAKGRNSNILDISYLNDIYQLNDYISTNVEIQVD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 115 DG----RKNCDPLCDLNSPFHLLAN--LTRRNNGTTSVFTYPDMPYSGLDIFLGLHLSNADFEPPTERISSKSLVLWYFS 188
Cdd:pfam02460 84 GIiisfKDLCSRYCDLNCPVNKHYNgmLLSRRHNTRIDITYPIMPVLGTPIYLGPHFGGVDFEPPGNISYAKAIVLWYFL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 189 RSDTPEGKLAFKDAIDELFQLSKNSSAFEHVQFTIFSDQVANREMIRGAIEATTLMTIGFFLLLTQVIIVIVRLSS---- 264
Cdd:pfam02460 164 KFDEEEVEEDSKEWEDELSQLLHNKYASEHIQFTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSIIVSVTLSSytid 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 265 -VKMAFYLVATSLLTPMAATVASFGAICWMGFPSFSIQCVTPFLVLGIGVDDAFILLHRWKHHIAITDTPRRLEQVIVDV 343
Cdd:pfam02460 244 wVRSKPILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVCVTPFLVLAIGVDDMFLMVAAWQRTTATLSVKKRMGEALSEA 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 344 GPSITITSLTNIIAFGIGFLTPTPQMSLFCLTASLALLLDYIFTYTILAPIVFLCNDPDYKS--------------IANE 409
Cdd:pfam02460 324 GVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAICAKPEAEGrhclfvwatsspqrIDSE 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 410 T-EPKISR------ADTWLSKYSSFVCSVKGRVACIMVLLGMYALTTYGVVTMKTTFEPAKAFPSNSKLVDSLSNI-KPV 481
Cdd:pfam02460 404 GsEPDKSHnieqlkSRFFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVLEDSPLVEYLSLReKHF 483
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 482 FNRYFPITVIVNNPPNIEIKAEYDSFNNMMDRLEHVPGIRGDNRSLIFLPQYVNFDKTMNILSTLVGEKYrPSYDNLPTW 561
Cdd:pfam02460 484 WPEGLQIQVAVNNPPNLTIPESRDRMNEMVDEFENTPYSLGPNSTLFWLREYENFLSTLNMEEEEDEEKE-WSYGNLPSF 562
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 562 MDAIGNPPLVKYHMGDDNKTIVTAFRLTLLGKGMSEWAERARAMQHIRTILHEESQFNATLFDCDSAILSIILTVGTDLI 641
Cdd:pfam02460 563 LKAPGNSHWAGDLVWDDNTTMVTKFRFTLAGKGLSTWNDRTRALQEWRSIADQYPEFNVTVFDEDAPFADQYLTILPSTI 642
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 642 GSIAVTVVCMAIVCFVFIANFNAVAVITSVIASICYVLVGGLSLWGADLDPVIQVDVLLATGFSVDYTAHVAYNFFRARG 721
Cdd:pfam02460 643 QNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFSVDFSAHIAYHFVRSRG 722
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17508519 722 -TPQERVYSSLAEMAMPMCEAGLSTFLCMLPLIFVPTYAIVCFAKTVFLVVAIGLLHGLFILPVILALFSK 791
Cdd:pfam02460 723 dTPAERVVDALEALGWPVFQGGLSTILGVLVLLFVPSYMVVVFFKTVFLVVAIGLLHGLFILPIILSLFVT 793
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
194-791 |
9.58e-30 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 126.51 E-value: 9.58e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 194 EGKLAFKDAIDELFQLSKnSSAFEHVQFTIFSDQVANREMIRGAI-EATTLMTIGFFLLLtqvIIVIVRLSSVKmafyLV 272
Cdd:COG1033 174 SSDLDRKEVVAEIRAIIA-KYEDPGVEVYLTGFPVLRGDIAEAIQsDLAIFFPLALLLIL---LLLFLFFRSLR----GV 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 273 ATSLLTPMAATVASFGAICWMGFP--SFSIqcVTPFLVLGIGVDDAFILLHRWKHHIAITDTPRR-LEQVIVDVGPSITI 349
Cdd:COG1033 246 LLPLLVVLLAVIWTLGLMGLLGIPlsPLTI--LVPPLLLAIGIDYGIHLLNRYREERRKGLDKREaLREALRKLGPPVLL 323
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 350 TSLTNIIAFGIGFLTPTPQMSLFCLTASLALLLDYIFTYTILAPIVFLCNDPDYKSIANETEPKISRadtWLSKYSSFVc 429
Cdd:COG1033 324 TSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLPALLSLLPRPKPKTRRLKKPPELGR---LLAKLARFV- 399
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 430 sVKGRVACIMVLLGMYALTTYGVVTMKTTFEPAKAFPSNSKLVDSLSNIKPVFNRYFPITVIVNNPPNIEIK-----AEY 504
Cdd:COG1033 400 -LRRPKVILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSPIRQDLDFIEENFGGSDPLEVVVDTGEPDGLKdpevlKEI 478
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 505 DSFNNMMDRLEHVPGIRGdnrsliflpqYVNFDKTMNILStlvgEKYRPSYDNLPTWMDAIG--------NPPLVKYHM- 575
Cdd:COG1033 479 DRLQDYLESLPEVGKVLS----------LADLVKELNQAL----NEGDPKYYALPESRELLAqlllllssPPGDDLSRFv 544
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 576 -GDDNKTIVTAFRLTLLGKGMSEWAERARAmqHIRTIL-HEESQFNATlfdcDSAIL--SIILTVGTDLIGSIAVTVVCM 651
Cdd:COG1033 545 dEDYSAARVTVRLKDLDSEEIKALVEEVRA--FLAENFpPDGVEVTLT----GSAVLfaAINESVIESQIRSLLLALLLI 618
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 652 AIVCFVFIANFNA--VAVITSVIASIcyVLVGGLSLWGADLDPVIQVDVLLATGFSVDYTAHVAYNFFRAR---GTPQER 726
Cdd:COG1033 619 FLLLLLAFRSLRLglISLIPNLLPIL--LTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYREERrkgGDLEEA 696
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17508519 727 VYSSLAEMAMPMCEAGLSTFLCMLPLIFVPTYAIVCFAKTVFLVVAIGLLHGLFILPVILALFSK 791
Cdd:COG1033 697 IRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLLLDP 761
|
|
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
265-789 |
1.35e-20 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 97.67 E-value: 1.35e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 265 VKMAFYLVATSLLTPMAATVASFGAICWMGFPS-FSIQCVTPFLVLGIGVDDAFIL------LHRWKHHIAITDTP---- 333
Cdd:TIGR00917 603 VTSKVLLGLSGILIVMLSVLGSVGVFSAVGLKStLIIMEVIPFLVLAVGVDNIFILvffyfyLEYFYRQVGVDNEQeltl 682
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 334 -RRLEQVIVDVGPSITITSLTNIIAFGIGFLTPTPQMSLFCLTASLALLLDYIFTYTILAPIV--------------FLC 398
Cdd:TIGR00917 683 eRRLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLvldfkrtedkrvdcFPC 762
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 399 NDPDYKSIANETEpKISRADTWLSK-----YSSFVCSVKGRVACIMVLLGMyALTTYGVVT-MKTTFEPAKAFPSNSKLV 472
Cdd:TIGR00917 763 IKTSKSSISAEKG-SGQRKAGLLTRyfkevYAPVLLHWIVKIVVIAFFVGL-LMAGIALSTrVEIGLDQQIVLPQDSYLQ 840
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 473 DSLSNIKPVFNRYFPITVIVNNPPNIEIKAEYDSFNNMMDRLEHVPGIRGDNRSLI------FLPQYVNF---------- 536
Cdd:TIGR00917 841 IYFASLTPLLEVGPPFYIVIKGDYNYTDFESQNKLCTMGGCDKDSIVNVFNNLSYIakpassWLDDYLVWlspqascccr 920
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 537 DKTMNILSTLVGE------------KYRPSYDN----LPTWMDAIGNPPLVK--------YHMGDDNKTIVTAFRL---- 588
Cdd:TIGR00917 921 KFTNGTFCNGPDPqcfrcadlssdaQGRPSTTQfkekLPWFLNALPSADCAKgghaayssAVDLQGYATIIQASSFrtyh 1000
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 589 TLLGKgMSEWAERARAMQHIRTILHEESQFNATLFDCDSAILSIILTVGTDLIGSIAVTVVCMAIVCFVFIA-NFNAVAV 667
Cdd:TIGR00917 1001 TPLNT-QVDFINAMRAAQEFAAKVSRSSKMEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLQlNALSVVN 1079
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 668 ITSVIASICYVLVGGLSLWGADLDPVIQVDVLLATGFSVDYTAHVAYNFFRA-RGTPQERVYSSLAEMAMPMCEA-GLST 745
Cdd:TIGR00917 1080 LIMSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGkHFSRNHRAKEALGGMGSSVFSGiTLTK 1159
|
570 580 590 600
....*....|....*....|....*....|....*....|....*
gi 17508519 746 FLCMLPLIFVPTYAIVCFAKTVFL-VVAIGLLHGLFILPVILALF 789
Cdd:TIGR00917 1160 LVGVVVLGFSRSEIFVVYYFRMYLaLVLLGFLHGLVFLPVLLSVL 1204
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
35-791 |
0e+00 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 975.30 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 35 GLVHIRLEPDIRkAFSPDDSDAGYETRVWLEYYGLDIYPERAFCIFTAKRENSSILQEGALADIYTVDNRLSAAVGYQDG 114
Cdd:pfam02460 5 DIVYTRTPDDAR-SFTERGVRSEYEPLVENKFFPGDSYPEARFLIITAKGRNSNILDISYLNDIYQLNDYISTNVEIQVD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 115 DG----RKNCDPLCDLNSPFHLLAN--LTRRNNGTTSVFTYPDMPYSGLDIFLGLHLSNADFEPPTERISSKSLVLWYFS 188
Cdd:pfam02460 84 GIiisfKDLCSRYCDLNCPVNKHYNgmLLSRRHNTRIDITYPIMPVLGTPIYLGPHFGGVDFEPPGNISYAKAIVLWYFL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 189 RSDTPEGKLAFKDAIDELFQLSKNSSAFEHVQFTIFSDQVANREMIRGAIEATTLMTIGFFLLLTQVIIVIVRLSS---- 264
Cdd:pfam02460 164 KFDEEEVEEDSKEWEDELSQLLHNKYASEHIQFTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSIIVSVTLSSytid 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 265 -VKMAFYLVATSLLTPMAATVASFGAICWMGFPSFSIQCVTPFLVLGIGVDDAFILLHRWKHHIAITDTPRRLEQVIVDV 343
Cdd:pfam02460 244 wVRSKPILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVCVTPFLVLAIGVDDMFLMVAAWQRTTATLSVKKRMGEALSEA 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 344 GPSITITSLTNIIAFGIGFLTPTPQMSLFCLTASLALLLDYIFTYTILAPIVFLCNDPDYKS--------------IANE 409
Cdd:pfam02460 324 GVSITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAICAKPEAEGrhclfvwatsspqrIDSE 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 410 T-EPKISR------ADTWLSKYSSFVCSVKGRVACIMVLLGMYALTTYGVVTMKTTFEPAKAFPSNSKLVDSLSNI-KPV 481
Cdd:pfam02460 404 GsEPDKSHnieqlkSRFFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVLEDSPLVEYLSLReKHF 483
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 482 FNRYFPITVIVNNPPNIEIKAEYDSFNNMMDRLEHVPGIRGDNRSLIFLPQYVNFDKTMNILSTLVGEKYrPSYDNLPTW 561
Cdd:pfam02460 484 WPEGLQIQVAVNNPPNLTIPESRDRMNEMVDEFENTPYSLGPNSTLFWLREYENFLSTLNMEEEEDEEKE-WSYGNLPSF 562
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 562 MDAIGNPPLVKYHMGDDNKTIVTAFRLTLLGKGMSEWAERARAMQHIRTILHEESQFNATLFDCDSAILSIILTVGTDLI 641
Cdd:pfam02460 563 LKAPGNSHWAGDLVWDDNTTMVTKFRFTLAGKGLSTWNDRTRALQEWRSIADQYPEFNVTVFDEDAPFADQYLTILPSTI 642
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 642 GSIAVTVVCMAIVCFVFIANFNAVAVITSVIASICYVLVGGLSLWGADLDPVIQVDVLLATGFSVDYTAHVAYNFFRARG 721
Cdd:pfam02460 643 QNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFSVDFSAHIAYHFVRSRG 722
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17508519 722 -TPQERVYSSLAEMAMPMCEAGLSTFLCMLPLIFVPTYAIVCFAKTVFLVVAIGLLHGLFILPVILALFSK 791
Cdd:pfam02460 723 dTPAERVVDALEALGWPVFQGGLSTILGVLVLLFVPSYMVVVFFKTVFLVVAIGLLHGLFILPIILSLFVT 793
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
194-791 |
9.58e-30 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 126.51 E-value: 9.58e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 194 EGKLAFKDAIDELFQLSKnSSAFEHVQFTIFSDQVANREMIRGAI-EATTLMTIGFFLLLtqvIIVIVRLSSVKmafyLV 272
Cdd:COG1033 174 SSDLDRKEVVAEIRAIIA-KYEDPGVEVYLTGFPVLRGDIAEAIQsDLAIFFPLALLLIL---LLLFLFFRSLR----GV 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 273 ATSLLTPMAATVASFGAICWMGFP--SFSIqcVTPFLVLGIGVDDAFILLHRWKHHIAITDTPRR-LEQVIVDVGPSITI 349
Cdd:COG1033 246 LLPLLVVLLAVIWTLGLMGLLGIPlsPLTI--LVPPLLLAIGIDYGIHLLNRYREERRKGLDKREaLREALRKLGPPVLL 323
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 350 TSLTNIIAFGIGFLTPTPQMSLFCLTASLALLLDYIFTYTILAPIVFLCNDPDYKSIANETEPKISRadtWLSKYSSFVc 429
Cdd:COG1033 324 TSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLPALLSLLPRPKPKTRRLKKPPELGR---LLAKLARFV- 399
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 430 sVKGRVACIMVLLGMYALTTYGVVTMKTTFEPAKAFPSNSKLVDSLSNIKPVFNRYFPITVIVNNPPNIEIK-----AEY 504
Cdd:COG1033 400 -LRRPKVILVVALVLAVVSLYGISRLKVEYDFEDYLPEDSPIRQDLDFIEENFGGSDPLEVVVDTGEPDGLKdpevlKEI 478
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 505 DSFNNMMDRLEHVPGIRGdnrsliflpqYVNFDKTMNILStlvgEKYRPSYDNLPTWMDAIG--------NPPLVKYHM- 575
Cdd:COG1033 479 DRLQDYLESLPEVGKVLS----------LADLVKELNQAL----NEGDPKYYALPESRELLAqlllllssPPGDDLSRFv 544
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 576 -GDDNKTIVTAFRLTLLGKGMSEWAERARAmqHIRTIL-HEESQFNATlfdcDSAIL--SIILTVGTDLIGSIAVTVVCM 651
Cdd:COG1033 545 dEDYSAARVTVRLKDLDSEEIKALVEEVRA--FLAENFpPDGVEVTLT----GSAVLfaAINESVIESQIRSLLLALLLI 618
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 652 AIVCFVFIANFNA--VAVITSVIASIcyVLVGGLSLWGADLDPVIQVDVLLATGFSVDYTAHVAYNFFRAR---GTPQER 726
Cdd:COG1033 619 FLLLLLAFRSLRLglISLIPNLLPIL--LTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYREERrkgGDLEEA 696
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17508519 727 VYSSLAEMAMPMCEAGLSTFLCMLPLIFVPTYAIVCFAKTVFLVVAIGLLHGLFILPVILALFSK 791
Cdd:COG1033 697 IRRALRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLLLDP 761
|
|
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
265-789 |
1.35e-20 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 97.67 E-value: 1.35e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 265 VKMAFYLVATSLLTPMAATVASFGAICWMGFPS-FSIQCVTPFLVLGIGVDDAFIL------LHRWKHHIAITDTP---- 333
Cdd:TIGR00917 603 VTSKVLLGLSGILIVMLSVLGSVGVFSAVGLKStLIIMEVIPFLVLAVGVDNIFILvffyfyLEYFYRQVGVDNEQeltl 682
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 334 -RRLEQVIVDVGPSITITSLTNIIAFGIGFLTPTPQMSLFCLTASLALLLDYIFTYTILAPIV--------------FLC 398
Cdd:TIGR00917 683 eRRLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLvldfkrtedkrvdcFPC 762
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 399 NDPDYKSIANETEpKISRADTWLSK-----YSSFVCSVKGRVACIMVLLGMyALTTYGVVT-MKTTFEPAKAFPSNSKLV 472
Cdd:TIGR00917 763 IKTSKSSISAEKG-SGQRKAGLLTRyfkevYAPVLLHWIVKIVVIAFFVGL-LMAGIALSTrVEIGLDQQIVLPQDSYLQ 840
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 473 DSLSNIKPVFNRYFPITVIVNNPPNIEIKAEYDSFNNMMDRLEHVPGIRGDNRSLI------FLPQYVNF---------- 536
Cdd:TIGR00917 841 IYFASLTPLLEVGPPFYIVIKGDYNYTDFESQNKLCTMGGCDKDSIVNVFNNLSYIakpassWLDDYLVWlspqascccr 920
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 537 DKTMNILSTLVGE------------KYRPSYDN----LPTWMDAIGNPPLVK--------YHMGDDNKTIVTAFRL---- 588
Cdd:TIGR00917 921 KFTNGTFCNGPDPqcfrcadlssdaQGRPSTTQfkekLPWFLNALPSADCAKgghaayssAVDLQGYATIIQASSFrtyh 1000
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 589 TLLGKgMSEWAERARAMQHIRTILHEESQFNATLFDCDSAILSIILTVGTDLIGSIAVTVVCMAIVCFVFIA-NFNAVAV 667
Cdd:TIGR00917 1001 TPLNT-QVDFINAMRAAQEFAAKVSRSSKMEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLQlNALSVVN 1079
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 668 ITSVIASICYVLVGGLSLWGADLDPVIQVDVLLATGFSVDYTAHVAYNFFRA-RGTPQERVYSSLAEMAMPMCEA-GLST 745
Cdd:TIGR00917 1080 LIMSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGkHFSRNHRAKEALGGMGSSVFSGiTLTK 1159
|
570 580 590 600
....*....|....*....|....*....|....*....|....*
gi 17508519 746 FLCMLPLIFVPTYAIVCFAKTVFL-VVAIGLLHGLFILPVILALF 789
Cdd:TIGR00917 1160 LVGVVVLGFSRSEIFVVYYFRMYLaLVLLGFLHGLVFLPVLLSVL 1204
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
265-398 |
6.32e-20 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 87.25 E-value: 6.32e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 265 VKMAFYLVATSLLTPMAATVASFGAICWMGFP-SFSIQCVTPFLVLGIGVDDAFILLHRWKHHIAITDTPRRLEQVIVDV 343
Cdd:pfam12349 2 VKSKFGLGLAGVIIVLASVASSLGLCAYFGLPlTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDVSERIAEALGEV 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 17508519 344 GPSITITSLTNIIAFGIGFLTPTPQMSLFCLTASLALLLDYIFTYTILAPIVFLC 398
Cdd:pfam12349 82 GPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLD 136
|
|
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
246-789 |
9.01e-18 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 88.40 E-value: 9.01e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 246 IGFFLLLTQVIIVIVRLSSVKMAFYLVATSLLTPMAATVASFGAICWMG--FPSFSIQcVTPFLVLGIGVDDAFILLHRW 323
Cdd:TIGR00918 404 SGYLLMLAYACLTMLRWDCAKSQGSVGLAGVLLVALSVAAGLGLCALLGisFNAATTQ-VLPFLALGVGVDDVFLLAHAF 482
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 324 KHHIAITDTPRRLEQVIVDVGPSITITSLTNIIAFGIGFLTPTPQMSLFCLTASLALLLDYIFTYTILAPI--------- 394
Cdd:TIGR00918 483 SETGQNIPFEERTGECLKRTGASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAIlsldlrrre 562
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 395 -----VFLC---------------------------------------NDPD---YKSIAN------------------- 408
Cdd:TIGR00918 563 drrldIFCCffspcsarviqiepqayadgsappvysshmqstvqlrteYDPGtqhYYTTNEprshlsvqpsdplscqspd 642
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 409 -----------ETEPKISRADTWLSK----------YSSFVCSVKGRVACIMVLLGMYALTTYGVVTMKTTFEPAKAFPS 467
Cdd:TIGR00918 643 iagstrdllsqFEDSKAACLSLPCARwtlatfaekhYAPFLLQSWAKVVVIFLFLALLGLSLYGTTRVQDGLDLTDIVPR 722
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 468 NSKLVDSLSNIKPVFNRYFPITVIVNNPPNIEIKAEYDSFNNMMDRLEHVpgIRGDNRSL-----------------IF- 529
Cdd:TIGR00918 723 DTNEHDFLDAQFRYFSFYNMYAVTQGNFDYPTQQQLLYDLHQSFSSVKYV--LKEDNGQLprmwlhyfrdwlqglqkAFd 800
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 530 --------------------------LPQYVNFDKTMNIlSTLVGEKY---------RPSYDNLPTWM--DAIG------ 566
Cdd:TIGR00918 801 edwrdgritkenyrngsddavlayklLVQTGHRDKPVDK-EQLTTQRLvnadgiinpNAFYIYLSAWVsnDPVAyaasqa 879
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 567 --NPPLVKYhMGDDNKTIVTAFRLT-----------LLGKGMSEWAERARAMQHIRTILHEESQFNATLFDCDSAIL--S 631
Cdd:TIGR00918 880 niYPHPPEW-LHDKNDYDPENLRIPaaepleyaqfpFYLNGLRETSQFVEAIEHVRAICNNYEGFGLPSYPSGYPFLfwE 958
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 632 IILTVGTDLIGSIAVTVVCMAIVCFVFIANFNAVAVITSVIASICYVLVGGLSLWGADLDPVIQVDVLLATGFSVDYTAH 711
Cdd:TIGR00918 959 QYMGLRHWLLLSISVVLACTFLVCALLLLNPWTAGLIVLVLALMTVELFGMMGLLGIKLSAIPVVILIASVGIGVEFTVH 1038
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17508519 712 VAYNFFRARGTPQERVYSSLAEMAMPMCEAGLSTFLCMLPLIFVPTYAIVCFAKTVFLVVAI-GLLHGLFILPVILALF 789
Cdd:TIGR00918 1039 IALGFLTAIGDRNRRAVLALEHMFAPVLDGALSTLLGVLMLAGSEFDFIVRYFFAVLAVLTClGVLNGLVLLPVLLSMF 1117
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
418-791 |
2.29e-14 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 77.21 E-value: 2.29e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 418 DTWLSKYSSFVcsVKGRVACIMVLLGMYALTTYGVVTMKTTFEPAKAFPSNSKLVDSLSNIKPVFNRYFPITVIVNNPPN 497
Cdd:COG1033 1 ERLMERLARFI--LRHRKLVLLLFLLLTLLLAYGAPKLEVDTDFESLLPEDDPSVQAYDEFEEEFGGDDTVVVAVEGKDD 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 498 IEIKAEYDSFNNMMDRLEHVPGIrgdnRSLIFLPQYVNFDKTMNILStlVGEKYRPSYDNLPTWMDAI-----GNPPLVK 572
Cdd:COG1033 79 IFTPETLEALRELTEELEEIPGV----DSVTSLTNVRATEGTEDGLT--VEPLIPDELPASPEELAELrekvlSSPLYVG 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 573 YHMGDDNKTivTAFRLTLLGKGMSEWAERARAMQHIRTILHEESQFNATLFDCDSAILS--IILTVGTDLIGSIAVTVVC 650
Cdd:COG1033 153 RLVSPDGKA--TLIVVTLDPDPLSSDLDRKEVVAEIRAIIAKYEDPGVEVYLTGFPVLRgdIAEAIQSDLAIFFPLALLL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 651 MAIVCFVFIANFNAVAV-ITSVIASICYVLvGGLSLWGADLDPVIQVDVLLATGFSVDYTAHV--AYNFFRARG-TPQER 726
Cdd:COG1033 231 ILLLLFLFFRSLRGVLLpLLVVLLAVIWTL-GLMGLLGIPLSPLTILVPPLLLAIGIDYGIHLlnRYREERRKGlDKREA 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17508519 727 VYSSLAEMAMPMCEAGLSTFLCMLPLIFVPTYAIVCFAKTVFLVVAIGLLHGLFILPVILALFSK 791
Cdd:COG1033 310 LREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLPALLSLLPR 374
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
139-397 |
3.68e-11 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 66.78 E-value: 3.68e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 139 RNNGTTSVFTYPDM-----PYSGLDIFLGLHLSNADFEPPTERISSKSLVLWYFSRSDTPEGKLAFKDAIDELFQlskns 213
Cdd:TIGR00921 465 ATGVAARVFGAPSIidlvkEVEGLPAPERSALEPIPEDEEGGYISGGQIKVAVIQVQLKQGEPKVQGRKILRDVQ----- 539
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 214 saFEH----VQFTIFSDQVANREMIRGAIEATTLMTI-GFFLLLTQVIIVIVRLssvkmafyLVATSLLTPMAATV-ASF 287
Cdd:TIGR00921 540 --HEHpppgVKVGVTGLPVAFAEMHELVNEGMRRMTIaGAILVLMILLAVFRNP--------IKAVFPLIAIGSGIlWAI 609
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 288 GAICWMGFPSFSIQCVTPFLVLGIGVDDAFILLHRWKHHIAITDTPRRLEQVIVDVGPSITITSLTNIIAFGIGFLTPTP 367
Cdd:TIGR00921 610 GLMGLRGIPSFLAMATTISIILGLGMDYSIHLAERYFEERKEHGPKEAITHTMERTGPGILFSGLTTAGGFLSLLLSHFP 689
|
250 260 270
....*....|....*....|....*....|
gi 17508519 368 QMSLFCLTASLALLLDYIFTYTILAPIVFL 397
Cdd:TIGR00921 690 IMRNFGLVQGIGVLSSLTAALVVFPALLVL 719
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
234-788 |
4.47e-08 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 56.77 E-value: 4.47e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 234 IRGAIEATTLMTIGFFLLLTQVIIVIVRLSSVKMAFYLVATslLTPMAATVA-SFGAICWMGFPsFSIQCVTPF-LVLGI 311
Cdd:TIGR00921 183 INYDIEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLP--LVIILFGVAwVLGIMGWLGIP-LYATTLLAVpMLIGV 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 312 GVDDAFILLHRWKHHIAI-TDTPRRLEQVIVDVGPSITITSLTNIIAFGIGFLTPTPQMSLFCLTASLALLLDYIFTYTI 390
Cdd:TIGR00921 260 GIDYGIQTLNRYEEERDIgRAKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLV 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 391 LAPIVFLC----NDPDYKSIANETEP-KISRAdtwLSKYSSFVcsVKGRVACIMVLLGMYALTTYGVVTMKTTFEPAKAF 465
Cdd:TIGR00921 340 LPALLQSIdigrEKVKKEIIAIGGKSsEIEEE---LSKVLSIT--VRHPVPALVAALIITGLGLYGAAGIKPEVNIEKFI 414
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 466 PSNSKLVDSLSNIKPVFNRYFPITVIVnnppnIEIKAEYD-SFNNMMDRLE-HVPGIRGDNRslIFLPQYVnfdktmnil 543
Cdd:TIGR00921 415 PQDLPSLQARKVIESHMGGSHDFATIL-----VKADDVRDpELVRFMDELSrDIKATGVAAR--VFGAPSI--------- 478
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 544 STLVGEKYR-PSYDNLPtwMDAIGNPPLVKYHMGDDNKTIVTAFRLTLLG-KGMSEWAERARAMQHIRTILHEESQFNAT 621
Cdd:TIGR00921 479 IDLVKEVEGlPAPERSA--LEPIPEDEEGGYISGGQIKVAVIQVQLKQGEpKVQGRKILRDVQHEHPPPGVKVGVTGLPV 556
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 622 LFdcdsAILSIILTVGTDLIGSIAVTVVCMaIVCFVFIANFNAVAVITSVIASICYVlVGGLSLWGADLDPVIQVDVLLA 701
Cdd:TIGR00921 557 AF----AEMHELVNEGMRRMTIAGAILVLM-ILLAVFRNPIKAVFPLIAIGSGILWA-IGLMGLRGIPSFLAMATTISII 630
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 702 TGFSVDYTAHVAYNFF--RARGTPQERVYSSLAEMAMPMCEAGLSTFLCMLPLIFVPTYAIVCFAktvfLVVAIGLLHGL 779
Cdd:TIGR00921 631 LGLGMDYSIHLAERYFeeRKEHGPKEAITHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFG----LVQGIGVLSSL 706
|
570
....*....|...
gi 17508519 780 F----ILPVILAL 788
Cdd:TIGR00921 707 TaalvVFPALLVL 719
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
190-387 |
2.84e-07 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 54.09 E-value: 2.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 190 SDTpEGKLAFKDAIDELFQLSKNssAFEHVQFT-----IFSdqVANREMIRGaiEATTLMTIGFFLLLTQVIIVIVRLSS 264
Cdd:COG4258 203 FDT-DAQQQLVAALRAAFAALNA--AFPGAQLLltgagLFA--VAAAQQIKH--DISTIGLISLLGILLLLLLVFRSLRP 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 265 VKMAFYLVATSLLTPMAATVASFGAICWM--GFpSFSIqcvtpflvLGIGVDDAF-ILLHRWKHHiaitdtPRRLEQVIV 341
Cdd:COG4258 276 LLLGLLPVAVGALAGLAAVSLVFGSVHGItlGF-GSSL--------IGVAVDYSLhYLTHRRAAG------EWDPRAALR 340
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 17508519 342 DVGPSITITSLTNIIAFGIGFLTPTP---QMSLFcltASLALLLDYIFT 387
Cdd:COG4258 341 RIWPTLLLGLLTTVLGYLALLFSPFPglrQLGVF---AAAGLLAAALTT 386
|
|
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
198-462 |
4.55e-05 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 47.02 E-value: 4.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 198 AFKDAIDELfqlskNSSAFEHVQFTIFSDQVanrEMIRGAIEA--TTLMtIGFFLlltqVIIVI-VRLSSVKMAFyLVAT 274
Cdd:COG0841 298 AVRAKLEEL-----QASLPEGVELTIVYDQS---EFIRASIEEvvKTLL-EAILL----VVLVVfLFLRSWRATL-IPAV 363
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 275 SLltPMAaTVASFGAICWMGFpsfSIQCVTPF-LVLGIG--VDDAFILL---HRwkhHIAITDTPRrleQVIVD----VG 344
Cdd:COG0841 364 AI--PVS-LIGTFAVMYLLGF---SLNILTLFaLVLAIGivVDDAIVVVeniER---HMEEGLSPL---EAAIKgareVA 431
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 345 PSITITSLTNIIAFG-IGFLT-PTPQ-MSLFCLTASLALLLDYIFTYTILaPIvfLCN---DPDYKSIANETEPKISRAD 418
Cdd:COG0841 432 GAVIASTLTLVAVFLpLAFMGgITGQlFRQFALTVAIALLISLFVALTLT-PA--LCArllKPHPKGKKGRFFRAFNRGF 508
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 17508519 419 TWLSK-YSSFV-CSVKGRVACIMVLLGMYALTTYGVVTMKTTFEPA 462
Cdd:COG0841 509 DRLTRgYGRLLrWALRHRKLTLLVALALLALSVLLFGRLPTEFFPE 554
|
|
| SecD_SecF |
pfam02355 |
Protein export membrane protein; This family consists of various prokaryotic SecD and SecF ... |
635-792 |
3.33e-04 |
|
Protein export membrane protein; This family consists of various prokaryotic SecD and SecF protein export membrane proteins. This SecD and SecF proteins are part of the multimeric protein export complex comprising SecA, D, E, F, G, Y, and YajC. SecD and SecF are required to maintain a proton motive force.
Pssm-ID: 280510 [Multi-domain] Cd Length: 189 Bit Score: 42.59 E-value: 3.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 635 TVGTDLI--GSIAVTVVCMAIVCFVFIA--NFNAVAVITSVIASICyVLVGGLSLWGADLDPVIQVDVLLATGFSVDYTA 710
Cdd:pfam02355 24 TVGSELArkAVLALLFALLLILIYVGLRfeWRFALGAIIALAHDVI-ITVGVFSLFGIEVDLATVAALLTIIGYSVNDTV 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 711 HVaynFFRAR--------GTPQERVYSSLAEMAMPMCEAGLSTFLCMLPLIFVPTYAIVCFAKTVFLVVAIGLLHGLFIL 782
Cdd:pfam02355 103 VV---FDRVRenlrkktrATLNEIMNLSINQTLTRTINTSLTTLLVVVALFVFGGGSLKDFSLALLVGVIVGTYSSIFIA 179
|
170
....*....|
gi 17508519 783 PVILALFSKD 792
Cdd:pfam02355 180 SPILLDLGER 189
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
223-391 |
1.36e-03 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 41.89 E-value: 1.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 223 IFSDQVANREMIRGAIEATTLMTIgffllltqVIIVIVRLSSVKMAFYLVATSLLTPMAA--TVASFGAICWMGFPSFSI 300
Cdd:pfam03176 132 TVADLRDAGDRDLGLIEAVTLVVI--------FIILLIVYRSVVAALLPLLTVGLSLGAAqgLVAILAHILGIGLSTFAL 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 301 QCVTpFLVLGIGVDDAFILLHRwkHHIAITDTPRRLEQVIV---DVGPSITITSLTNIIAFGIGFLTPTPQMSLFCLTAS 377
Cdd:pfam03176 204 NLLV-VLLIAVGTDYALFLVSR--YREELRAGEDREEAVIRavrGTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIA 280
|
170
....*....|....
gi 17508519 378 LALLLDYIFTYTIL 391
Cdd:pfam03176 281 IGVLVDVLAALTLL 294
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
636-797 |
6.49e-03 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 40.21 E-value: 6.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 636 VGTDLIGSIAVTVVCMAIVCFVFIANFNAVAV-ITSVIASICYVLvGGLSLWGADLDPVIQVDVLLATGFSVDYTAHVAY 714
Cdd:TIGR00921 191 FGKDMGTTMAISGILVVLVLLLDFKRWWRPLLpLVIILFGVAWVL-GIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLN 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508519 715 NFFRARG---TPQERVYSSLAEMAMPMCEAGLSTFLCMLPLIFVPTYAIVCFAKTVFLVVAIGLLHGLFILPVILALFsk 791
Cdd:TIGR00921 270 RYEEERDigrAKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALLQSI-- 347
|
....*.
gi 17508519 792 DSINEK 797
Cdd:TIGR00921 348 DIGREK 353
|
|
| |
