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Conserved domains on  [gi|17506191|ref|NP_490715|]
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Importin N-terminal domain-containing protein [Caenorhabditis elegans]

Protein Classification

importin beta family protein( domain architecture ID 1563703)

importin beta family protein may function in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Importin_rep_4 super family cl40101
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ...
 263-354 1.32e-10

Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit.


The actual alignment was detected with superfamily member pfam18808:

Pssm-ID: 408579  Cd Length: 90  Bit Score: 59.01  E-value: 1.32e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506191    263 NKEKNEMVRQNAIEVICSYMESAPKGLKKyAPGALGPILETLLSCMTEMDDDvlNEW-LNEIEEEEDYEDIPIIAESAID 341
Cdd:pfam18808    1 NKDLDDAARQVALELLVTLAEAAPGMCRK-QPQFTNALVPICLSMMTEVDDA--EDWyTSDDLDDDDNEDNYVFGEQALD 77

                           90
                   ....*....|...
gi 17506191    342 RVACCINGKVMLP 354
Cdd:pfam18808   78 RLACRLGGKALLP 90
KAP95 super family cl27231
Karyopherin (importin) beta [Intracellular trafficking and secretion];
218-486 3.01e-10

Karyopherin (importin) beta [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5215:

Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 64.57  E-value: 3.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506191  218 VCNETSDEDDS--DGPLGEFAELASSLPKCLNTHMSQVLqVTLAIAGNKEKNEMVRQNAIE---VICS----------YM 282
Cdd:COG5215  226 VCEATQGNDEElqHAAFGCLNKIMMLYYKFMQSYMENAL-AALTGRFMKSQNDEVAIQAVEfwsTICEeeidgemedkYL 304

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506191  283 ESAPKGLKKYAPGALGPILETLLSCMTEMDDDVLNEWLNEIEEeedyedipiiAESAIDRVACCINGKVMLPVfLPLVEK 362
Cdd:COG5215  305 PEVPAQNHGFARAAVADVLPELLSLLEKQGEDYYGDDWNPSMA----------ASSCLQLFAQLKGDKIMRPV-LGFVEQ 373

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506191  363 LLTSEDWKMKHAALRAFSAVGEG-CQRSMEPHIEQIMAHITNYVNDAHPRVQYAACNAIGQMSSDFAPTLQKKCH-AAVI 440
Cdd:COG5215  374 NIRSESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHVAMIISPCGHlVLEV 453

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 17506191  441 PALLESLdrTDVPRVCAHAASALVNFAEECPK------SIIGQYLPFILQKL 486
Cdd:COG5215  454 SASLIGL--MDCPFRSINCSWRKENLVDHIAKavreveSFLAKFYLAILNAL 503
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
 895-922 7.82e-03

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


:

Pssm-ID: 460773  Cd Length: 31  Bit Score: 34.81  E-value: 7.82e-03
                           10        20
                   ....*....|....*....|....*...
gi 17506191    895 LIPIMYKLLGDEYPEVRQAASYGFGVMA 922
Cdd:pfam02985    1 LLPLLLKLLNDPSPEVREAAAEALGELA 28
 
Name Accession Description Interval E-value
Importin_rep_4 pfam18808
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ...
 263-354 1.32e-10

Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit.


Pssm-ID: 408579  Cd Length: 90  Bit Score: 59.01  E-value: 1.32e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506191    263 NKEKNEMVRQNAIEVICSYMESAPKGLKKyAPGALGPILETLLSCMTEMDDDvlNEW-LNEIEEEEDYEDIPIIAESAID 341
Cdd:pfam18808    1 NKDLDDAARQVALELLVTLAEAAPGMCRK-QPQFTNALVPICLSMMTEVDDA--EDWyTSDDLDDDDNEDNYVFGEQALD 77

                           90
                   ....*....|...
gi 17506191    342 RVACCINGKVMLP 354
Cdd:pfam18808   78 RLACRLGGKALLP 90
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
218-486 3.01e-10

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 64.57  E-value: 3.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506191  218 VCNETSDEDDS--DGPLGEFAELASSLPKCLNTHMSQVLqVTLAIAGNKEKNEMVRQNAIE---VICS----------YM 282
Cdd:COG5215  226 VCEATQGNDEElqHAAFGCLNKIMMLYYKFMQSYMENAL-AALTGRFMKSQNDEVAIQAVEfwsTICEeeidgemedkYL 304

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506191  283 ESAPKGLKKYAPGALGPILETLLSCMTEMDDDVLNEWLNEIEEeedyedipiiAESAIDRVACCINGKVMLPVfLPLVEK 362
Cdd:COG5215  305 PEVPAQNHGFARAAVADVLPELLSLLEKQGEDYYGDDWNPSMA----------ASSCLQLFAQLKGDKIMRPV-LGFVEQ 373

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506191  363 LLTSEDWKMKHAALRAFSAVGEG-CQRSMEPHIEQIMAHITNYVNDAHPRVQYAACNAIGQMSSDFAPTLQKKCH-AAVI 440
Cdd:COG5215  374 NIRSESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHVAMIISPCGHlVLEV 453

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 17506191  441 PALLESLdrTDVPRVCAHAASALVNFAEECPK------SIIGQYLPFILQKL 486
Cdd:COG5215  454 SASLIGL--MDCPFRSINCSWRKENLVDHIAKavreveSFLAKFYLAILNAL 503
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 369-423 3.38e-09

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 53.52  E-value: 3.38e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 17506191    369 WKMKHAALRAFSAVGEGCQRSMEPHIEQIMAHITNYVNDAHPRVQYAACNAIGQM 423
Cdd:pfam13513    1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
 895-922 7.82e-03

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


Pssm-ID: 460773  Cd Length: 31  Bit Score: 34.81  E-value: 7.82e-03
                           10        20
                   ....*....|....*....|....*...
gi 17506191    895 LIPIMYKLLGDEYPEVRQAASYGFGVMA 922
Cdd:pfam02985    1 LLPLLLKLLNDPSPEVREAAAEALGELA 28
 
Name Accession Description Interval E-value
Importin_rep_4 pfam18808
Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem ...
 263-354 1.32e-10

Importin repeat; The importin subunit beta-3 has a superhelical structure composed of tandem repeats structurally similar to HEAT repeats. This Pfam entry includes a single repeat unit.


Pssm-ID: 408579  Cd Length: 90  Bit Score: 59.01  E-value: 1.32e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506191    263 NKEKNEMVRQNAIEVICSYMESAPKGLKKyAPGALGPILETLLSCMTEMDDDvlNEW-LNEIEEEEDYEDIPIIAESAID 341
Cdd:pfam18808    1 NKDLDDAARQVALELLVTLAEAAPGMCRK-QPQFTNALVPICLSMMTEVDDA--EDWyTSDDLDDDDNEDNYVFGEQALD 77

                           90
                   ....*....|...
gi 17506191    342 RVACCINGKVMLP 354
Cdd:pfam18808   78 RLACRLGGKALLP 90
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
218-486 3.01e-10

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 64.57  E-value: 3.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506191  218 VCNETSDEDDS--DGPLGEFAELASSLPKCLNTHMSQVLqVTLAIAGNKEKNEMVRQNAIE---VICS----------YM 282
Cdd:COG5215  226 VCEATQGNDEElqHAAFGCLNKIMMLYYKFMQSYMENAL-AALTGRFMKSQNDEVAIQAVEfwsTICEeeidgemedkYL 304

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506191  283 ESAPKGLKKYAPGALGPILETLLSCMTEMDDDVLNEWLNEIEEeedyedipiiAESAIDRVACCINGKVMLPVfLPLVEK 362
Cdd:COG5215  305 PEVPAQNHGFARAAVADVLPELLSLLEKQGEDYYGDDWNPSMA----------ASSCLQLFAQLKGDKIMRPV-LGFVEQ 373

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506191  363 LLTSEDWKMKHAALRAFSAVGEG-CQRSMEPHIEQIMAHITNYVNDAHPRVQYAACNAIGQMSSDFAPTLQKKCH-AAVI 440
Cdd:COG5215  374 NIRSESWANREAAVMAFGSVMHGpCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHVAMIISPCGHlVLEV 453

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 17506191  441 PALLESLdrTDVPRVCAHAASALVNFAEECPK------SIIGQYLPFILQKL 486
Cdd:COG5215  454 SASLIGL--MDCPFRSINCSWRKENLVDHIAKavreveSFLAKFYLAILNAL 503
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 369-423 3.38e-09

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 53.52  E-value: 3.38e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 17506191    369 WKMKHAALRAFSAVGEGCQRSMEPHIEQIMAHITNYVNDAHPRVQYAACNAIGQM 423
Cdd:pfam13513    1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 358-463 1.63e-07

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 50.03  E-value: 1.63e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506191    358 PLVEKLLTSEDWKMKHAALRAFSAVGEgcqrsmephiEQIMAHITNYVNDAHPRVQYAACNAIGQMSSdfaptlqkkchA 437
Cdd:pfam13646    3 ALLQALLRDPDPEVRAAAIRALGRIGD----------PEAVPALLELLKDEDPAVRRAAAEALGKIGD-----------P 61

                           90       100
                   ....*....|....*....|....*.
gi 17506191    438 AVIPALLESLDRTDVPRVCAHAASAL 463
Cdd:pfam13646   62 EALPALLELLRDDDDDVVRAAAAEAL 87
HEAT COG1413
HEAT repeat [General function prediction only];
357-463 3.44e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 44.62  E-value: 3.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506191  357 LPLVEKLLTSEDWKMKHAALRAFSAVGEgcqrsmephiEQIMAHITNYVNDAHPRVQYAACNAIGQMSSDfaptlqkkch 436
Cdd:COG1413   49 VPALLEALKDPDPEVRAAAAEALGRIGD----------PEAVPALIAALKDEDPEVRRAAAEALGRLGDP---------- 108

                         90       100
                 ....*....|....*....|....*..
gi 17506191  437 aAVIPALLESLDRTDvPRVCAHAASAL 463
Cdd:COG1413  109 -AAVPALLEALKDPD-WEVRRAAARAL 133
HEAT COG1413
HEAT repeat [General function prediction only];
354-469 1.49e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.00  E-value: 1.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506191  354 PVFLPLVEKLLTSEDWKMKHAALRAFSAVGEgcqrsmephiEQIMAHITNYVNDAHPRVQYAACNAIGQMSSDfaptlqk 433
Cdd:COG1413   15 PAAVPALIAALADEDPDVRAAAARALGRLGD----------PRAVPALLEALKDPDPEVRAAAAEALGRIGDP------- 77

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 17506191  434 kchaAVIPALLESLDRTDvPRVCAHAASALVNFAEE 469
Cdd:COG1413   78 ----EAVPALIAALKDED-PEVRRAAAEALGRLGDP 108
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 405-469 6.64e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 36.93  E-value: 6.64e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17506191    405 VNDAHPRVQYAACNAIGQMSsdfaptlqkkcHAAVIPALLESLDRTDvPRVCAHAASALVNFAEE 469
Cdd:pfam13646    9 LRDPDPEVRAAAIRALGRIG-----------DPEAVPALLELLKDED-PAVRRAAAEALGKIGDP 61
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
 895-922 7.82e-03

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


Pssm-ID: 460773  Cd Length: 31  Bit Score: 34.81  E-value: 7.82e-03
                           10        20
                   ....*....|....*....|....*...
gi 17506191    895 LIPIMYKLLGDEYPEVRQAASYGFGVMA 922
Cdd:pfam02985    1 LLPLLLKLLNDPSPEVREAAAEALGELA 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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