|
Name |
Accession |
Description |
Interval |
E-value |
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
83-863 |
1.93e-156 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 478.77 E-value: 1.93e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 83 GYTPKNSLSRLENRLYREFLSSEGDPVMTTVLMTAKDGGS-MHRIKYLEEAQRQWLYISKNLSADVgNGEFMKFGDFCGH 161
Cdd:pfam02460 17 SFTERGVRSEYEPLVENKFFPGDSYPEARFLIITAKGRNSnILDISYLNDIYQLNDYISTNVEIQV-DGIIISFKDLCSR 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 162 YCQANDIIGYFLDAYKTKsaDPKMDGYQLNYPITTVMGYQLHLERNFFGVTVnqsDPVTNIQSMKVLTLPVLSEVRTFED 241
Cdd:pfam02460 96 YCDLNCPVNKHYNGMLLS--RRHNTRIDITYPIMPVLGTPIYLGPHFGGVDF---EPPGNISYAKAIVLWYFLKFDEEEV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 242 TDKLNKWELAVYNYATGYSAlegdDHLVEINVIGAEVVDTEMNKDAQKMVPYFIVGIVSMIIFIFCTVSISASYYGYFSW 321
Cdd:pfam02460 171 EEDSKEWEDELSQLLHNKYA----SEHIQFTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSIIVSVTLSSYTIDWVR 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 322 RIGLIALACLLVPILAILTAFGINNMLGNRTNSPMMIMPFLINGIGVNDAFLTLQNWLQHSPDLPSGKRLGYMLAEAGPS 401
Cdd:pfam02460 247 SKPILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVCVTPFLVLAIGVDDMFLMVAAWQRTTATLSVKKRMGEALSEAGVS 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 402 ITTTTLTNVIVFLIGWMNPTEEMSIFCLGCAISLLLAYVYTLTFFCPVLVLL---------------------LSERVNE 460
Cdd:pfam02460 327 ITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAICakpeaegrhclfvwatsspqrIDSEGSE 406
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 461 PSK----LEGTFNKVLGFYAKIICSRWTFALLIIGSLVYWGFGIYGTLGIRAVLNTAKILPLETPIRKPNRIIEETVWKE 536
Cdd:pfam02460 407 PDKshniEQLKSRFFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVLEDSPLVEYLSLREKHFWPE 486
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 537 FYPVTVIVNSPVDISNANALRAFDNLVHDFESMEKCRGSEYTISPIRDYQTYFYGVGAEDFDYEEEtvkntshSLDFSKL 616
Cdd:pfam02460 487 GLQIQVAVNNPPNLTIPESRDRMNEMVDEFENTPYSLGPNSTLFWLREYENFLSTLNMEEEEDEEK-------EWSYGNL 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 617 TGFLANPIYKHHKGGLKLNFSNPVpIRKVQLIFAYENVTSWDERIQIMQDWRTIASSHVALNVSVWNVNAMFVDQMLSLK 696
Cdd:pfam02460 560 PSFLKAPGNSHWAGDLVWDDNTTM-VTKFRFTLAGKGLSTWNDRTRALQEWRSIADQYPEFNVTVFDEDAPFADQYLTIL 638
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 697 GLAISNALVTLGCMAAVCVVFIRNPLSVGLATASILSISIGVTGYLCFWDLDLDPVTLCAVIVSIGMSVDFVAHVACHYQ 776
Cdd:pfam02460 639 PSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFSVDFSAHIAYHFV 718
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 777 VRYKEfeekgvlkriemkTPESRVVNSLSNVLWPMVQSASSTLLCVLPLGILQNYLPMVFVKTILLVVIWGMFHGLVLLP 856
Cdd:pfam02460 719 RSRGD-------------TPAERVVDALEALGWPVFQGGLSTILGVLVLLFVPSYMVVVFFKTVFLVVAIGLLHGLFILP 785
|
....*..
gi 17508525 857 CILAQFP 863
Cdd:pfam02460 786 IILSLFV 792
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
269-859 |
6.45e-26 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 114.57 E-value: 6.45e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 269 VEINVIGAEVVDTEMNKDAQK-MVPYFIVGIVSMIIFIFctvsisasyYGYFSWRIGLIALACLLVpilAILTAFGINNM 347
Cdd:COG1033 198 VEVYLTGFPVLRGDIAEAIQSdLAIFFPLALLLILLLLF---------LFFRSLRGVLLPLLVVLL---AVIWTLGLMGL 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 348 LGNRTNSPMMIMPFLINGIGVNDAFLTLQNWLQHSPD-LPSGKRLGYMLAEAGPSITTTTLTNVIVFL-IGWMN--PTEE 423
Cdd:COG1033 266 LGIPLSPLTILVPPLLLAIGIDYGIHLLNRYREERRKgLDKREALREALRKLGPPVLLTSLTTAIGFLsLLFSDipPIRD 345
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 424 MSIFclgCAISLLLAYVYTLTFFcPVLVLLLSERVNEPSKLE--GTFNKVLGFYAKIICSRWTfaLLIIGSLVYWGFGIY 501
Cdd:COG1033 346 FGIV---AAIGVLLAFLTSLTLL-PALLSLLPRPKPKTRRLKkpPELGRLLAKLARFVLRRPK--VILVVALVLAVVSLY 419
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 502 GTLGIRAVLNTAKILPLETPIRKPNRIIEEtvwkEF---YPVTVIVNSPVD--ISNANALRAFDNLVHDFESMEkcrGSE 576
Cdd:COG1033 420 GISRLKVEYDFEDYLPEDSPIRQDLDFIEE----NFggsDPLEVVVDTGEPdgLKDPEVLKEIDRLQDYLESLP---EVG 492
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 577 YTISPIRDYQTYFYGVGAEDFDYEE--ETVKNTSHSLDFSKLTGflanpiykhhkGGLKLNFSNPVPiRKVQLIFAYENV 654
Cdd:COG1033 493 KVLSLADLVKELNQALNEGDPKYYAlpESRELLAQLLLLLSSPP-----------GDDLSRFVDEDY-SAARVTVRLKDL 560
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 655 TSwDERIQIMQDWRTIASSHVA---LNVSVWNVNAMFVDQMLSL-KGLAISNALVtLGCMAAVCVVFIRNPLSVGLATAS 730
Cdd:COG1033 561 DS-EEIKALVEEVRAFLAENFPpdgVEVTLTGSAVLFAAINESViESQIRSLLLA-LLLIFLLLLLAFRSLRLGLISLIP 638
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 731 ILSISIGVTGYLCFWDLDLDPVTLCAVIVSIGMSVDFvahvACHYQVRYKEFEEKGvlkriemKTPESRVVNSLSNVLWP 810
Cdd:COG1033 639 NLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDY----TIHFLSRYREERRKG-------GDLEEAIRRALRTTGKA 707
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|
gi 17508525 811 MVQSASSTLLCVLPLgILQNYLPMV-FVKTILLVVIWGMFHGLVLLPCIL 859
Cdd:COG1033 708 ILFTSLTLAAGFGVL-LFSSFPPLAdFGLLLALGLLVALLAALLLLPALL 756
|
|
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
227-862 |
4.25e-20 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 96.52 E-value: 4.25e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 227 VLTLPVLSEVrtfEDTDKLNK---WELAVYNYATGYSAlegDDHLVEINVIGAEVVDTEMNKDAQKMVPYFIVGIVSMII 303
Cdd:TIGR00917 513 VVTFPVNNFV---NKTNKTEKavaWEKAFIQLAKDELL---PMVQATISFSAERSIEDELKRESTADVITIAISYLVMFA 586
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 304 FIFCTVSISASYYGYFSWRIGLIALACLLVPILAILTAFGINNMLGNRTNSPMM-IMPFLINGIGVNDAFLTLQNW---- 378
Cdd:TIGR00917 587 YISLTLGDSPRLKSLYVTSKVLLGLSGILIVMLSVLGSVGVFSAVGLKSTLIIMeVIPFLVLAVGVDNIFILVFFYfyle 666
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 379 -LQHSP------DLPSGKRLGYMLAEAGPSITTTTLTNVIVFLIGWMNPTEEMSIFCLGCAISLLLAYVYTLTFFCPVLV 451
Cdd:TIGR00917 667 yFYRQVgvdneqELTLERRLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLV 746
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 452 L----------------LLSERVNEPSKLEGTFNKVL------GFYAKIICSRWTFALLIIGSLVYWGFGIYGTLGIRAV 509
Cdd:TIGR00917 747 LdfkrtedkrvdcfpciKTSKSSISAEKGSGQRKAGLltryfkEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIG 826
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 510 LNTAKILPLETPIRKPNRIIEE--TVWKEFYPVTVIVNSPVDISNANAL------------RAFDNL----------VHD 565
Cdd:TIGR00917 827 LDQQIVLPQDSYLQIYFASLTPllEVGPPFYIVIKGDYNYTDFESQNKLctmggcdkdsivNVFNNLsyiakpasswLDD 906
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 566 FESMEKCRGSEYTISPIRDyqtYFYGVG----AEDFDYEEETVKNTSHSLDFSKLTGFL-ANPIYKHHKGGLKLnFSNPV 640
Cdd:TIGR00917 907 YLVWLSPQASCCCRKFTNG---TFCNGPdpqcFRCADLSSDAQGRPSTTQFKEKLPWFLnALPSADCAKGGHAA-YSSAV 982
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 641 PIRKVQLIFAYENVTSW-------DERIQIMQDWRTIASS---HVALNVSVWNVNAMFVDQMLSLKGLAISNALVTLGCM 710
Cdd:TIGR00917 983 DLQGYATIIQASSFRTYhtplntqVDFINAMRAAQEFAAKvsrSSKMEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAI 1062
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 711 AAVCVVFIR-NPLSVGLATASILSISIGVTGYLCFWDLDLDPVTLCAVIVSIGMSVDFVAHVACHYQVRYKefeekgvlk 789
Cdd:TIGR00917 1063 FIVCLFLLQlNALSVVNLIMSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKH--------- 1133
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17508525 790 riemktpESRvVNSLSNVLWPMVQSASS-----TLLCVLPLGILQNYLPMVF-VKTILLVVIWGMFHGLVLLPCILAQF 862
Cdd:TIGR00917 1134 -------FSR-NHRAKEALGGMGSSVFSgitltKLVGVVVLGFSRSEIFVVYyFRMYLALVLLGFLHGLVFLPVLLSVL 1204
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
83-863 |
1.93e-156 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 478.77 E-value: 1.93e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 83 GYTPKNSLSRLENRLYREFLSSEGDPVMTTVLMTAKDGGS-MHRIKYLEEAQRQWLYISKNLSADVgNGEFMKFGDFCGH 161
Cdd:pfam02460 17 SFTERGVRSEYEPLVENKFFPGDSYPEARFLIITAKGRNSnILDISYLNDIYQLNDYISTNVEIQV-DGIIISFKDLCSR 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 162 YCQANDIIGYFLDAYKTKsaDPKMDGYQLNYPITTVMGYQLHLERNFFGVTVnqsDPVTNIQSMKVLTLPVLSEVRTFED 241
Cdd:pfam02460 96 YCDLNCPVNKHYNGMLLS--RRHNTRIDITYPIMPVLGTPIYLGPHFGGVDF---EPPGNISYAKAIVLWYFLKFDEEEV 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 242 TDKLNKWELAVYNYATGYSAlegdDHLVEINVIGAEVVDTEMNKDAQKMVPYFIVGIVSMIIFIFCTVSISASYYGYFSW 321
Cdd:pfam02460 171 EEDSKEWEDELSQLLHNKYA----SEHIQFTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSIIVSVTLSSYTIDWVR 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 322 RIGLIALACLLVPILAILTAFGINNMLGNRTNSPMMIMPFLINGIGVNDAFLTLQNWLQHSPDLPSGKRLGYMLAEAGPS 401
Cdd:pfam02460 247 SKPILAALGLLSPVMAIVSSFGLLFWMGFPFNSIVCVTPFLVLAIGVDDMFLMVAAWQRTTATLSVKKRMGEALSEAGVS 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 402 ITTTTLTNVIVFLIGWMNPTEEMSIFCLGCAISLLLAYVYTLTFFCPVLVLL---------------------LSERVNE 460
Cdd:pfam02460 327 ITITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAICakpeaegrhclfvwatsspqrIDSEGSE 406
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 461 PSK----LEGTFNKVLGFYAKIICSRWTFALLIIGSLVYWGFGIYGTLGIRAVLNTAKILPLETPIRKPNRIIEETVWKE 536
Cdd:pfam02460 407 PDKshniEQLKSRFFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVLEDSPLVEYLSLREKHFWPE 486
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 537 FYPVTVIVNSPVDISNANALRAFDNLVHDFESMEKCRGSEYTISPIRDYQTYFYGVGAEDFDYEEEtvkntshSLDFSKL 616
Cdd:pfam02460 487 GLQIQVAVNNPPNLTIPESRDRMNEMVDEFENTPYSLGPNSTLFWLREYENFLSTLNMEEEEDEEK-------EWSYGNL 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 617 TGFLANPIYKHHKGGLKLNFSNPVpIRKVQLIFAYENVTSWDERIQIMQDWRTIASSHVALNVSVWNVNAMFVDQMLSLK 696
Cdd:pfam02460 560 PSFLKAPGNSHWAGDLVWDDNTTM-VTKFRFTLAGKGLSTWNDRTRALQEWRSIADQYPEFNVTVFDEDAPFADQYLTIL 638
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 697 GLAISNALVTLGCMAAVCVVFIRNPLSVGLATASILSISIGVTGYLCFWDLDLDPVTLCAVIVSIGMSVDFVAHVACHYQ 776
Cdd:pfam02460 639 PSTIQNIVITLICMFIVCFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFSVDFSAHIAYHFV 718
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 777 VRYKEfeekgvlkriemkTPESRVVNSLSNVLWPMVQSASSTLLCVLPLGILQNYLPMVFVKTILLVVIWGMFHGLVLLP 856
Cdd:pfam02460 719 RSRGD-------------TPAERVVDALEALGWPVFQGGLSTILGVLVLLFVPSYMVVVFFKTVFLVVAIGLLHGLFILP 785
|
....*..
gi 17508525 857 CILAQFP 863
Cdd:pfam02460 786 IILSLFV 792
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
269-859 |
6.45e-26 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 114.57 E-value: 6.45e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 269 VEINVIGAEVVDTEMNKDAQK-MVPYFIVGIVSMIIFIFctvsisasyYGYFSWRIGLIALACLLVpilAILTAFGINNM 347
Cdd:COG1033 198 VEVYLTGFPVLRGDIAEAIQSdLAIFFPLALLLILLLLF---------LFFRSLRGVLLPLLVVLL---AVIWTLGLMGL 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 348 LGNRTNSPMMIMPFLINGIGVNDAFLTLQNWLQHSPD-LPSGKRLGYMLAEAGPSITTTTLTNVIVFL-IGWMN--PTEE 423
Cdd:COG1033 266 LGIPLSPLTILVPPLLLAIGIDYGIHLLNRYREERRKgLDKREALREALRKLGPPVLLTSLTTAIGFLsLLFSDipPIRD 345
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 424 MSIFclgCAISLLLAYVYTLTFFcPVLVLLLSERVNEPSKLE--GTFNKVLGFYAKIICSRWTfaLLIIGSLVYWGFGIY 501
Cdd:COG1033 346 FGIV---AAIGVLLAFLTSLTLL-PALLSLLPRPKPKTRRLKkpPELGRLLAKLARFVLRRPK--VILVVALVLAVVSLY 419
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 502 GTLGIRAVLNTAKILPLETPIRKPNRIIEEtvwkEF---YPVTVIVNSPVD--ISNANALRAFDNLVHDFESMEkcrGSE 576
Cdd:COG1033 420 GISRLKVEYDFEDYLPEDSPIRQDLDFIEE----NFggsDPLEVVVDTGEPdgLKDPEVLKEIDRLQDYLESLP---EVG 492
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 577 YTISPIRDYQTYFYGVGAEDFDYEE--ETVKNTSHSLDFSKLTGflanpiykhhkGGLKLNFSNPVPiRKVQLIFAYENV 654
Cdd:COG1033 493 KVLSLADLVKELNQALNEGDPKYYAlpESRELLAQLLLLLSSPP-----------GDDLSRFVDEDY-SAARVTVRLKDL 560
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 655 TSwDERIQIMQDWRTIASSHVA---LNVSVWNVNAMFVDQMLSL-KGLAISNALVtLGCMAAVCVVFIRNPLSVGLATAS 730
Cdd:COG1033 561 DS-EEIKALVEEVRAFLAENFPpdgVEVTLTGSAVLFAAINESViESQIRSLLLA-LLLIFLLLLLAFRSLRLGLISLIP 638
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 731 ILSISIGVTGYLCFWDLDLDPVTLCAVIVSIGMSVDFvahvACHYQVRYKEFEEKGvlkriemKTPESRVVNSLSNVLWP 810
Cdd:COG1033 639 NLLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDY----TIHFLSRYREERRKG-------GDLEEAIRRALRTTGKA 707
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|
gi 17508525 811 MVQSASSTLLCVLPLgILQNYLPMV-FVKTILLVVIWGMFHGLVLLPCIL 859
Cdd:COG1033 708 ILFTSLTLAAGFGVL-LFSSFPPLAdFGLLLALGLLVALLAALLLLPALL 756
|
|
| 2A060601 |
TIGR00917 |
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ... |
227-862 |
4.25e-20 |
|
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]
Pssm-ID: 273337 [Multi-domain] Cd Length: 1205 Bit Score: 96.52 E-value: 4.25e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 227 VLTLPVLSEVrtfEDTDKLNK---WELAVYNYATGYSAlegDDHLVEINVIGAEVVDTEMNKDAQKMVPYFIVGIVSMII 303
Cdd:TIGR00917 513 VVTFPVNNFV---NKTNKTEKavaWEKAFIQLAKDELL---PMVQATISFSAERSIEDELKRESTADVITIAISYLVMFA 586
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 304 FIFCTVSISASYYGYFSWRIGLIALACLLVPILAILTAFGINNMLGNRTNSPMM-IMPFLINGIGVNDAFLTLQNW---- 378
Cdd:TIGR00917 587 YISLTLGDSPRLKSLYVTSKVLLGLSGILIVMLSVLGSVGVFSAVGLKSTLIIMeVIPFLVLAVGVDNIFILVFFYfyle 666
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 379 -LQHSP------DLPSGKRLGYMLAEAGPSITTTTLTNVIVFLIGWMNPTEEMSIFCLGCAISLLLAYVYTLTFFCPVLV 451
Cdd:TIGR00917 667 yFYRQVgvdneqELTLERRLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLV 746
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 452 L----------------LLSERVNEPSKLEGTFNKVL------GFYAKIICSRWTFALLIIGSLVYWGFGIYGTLGIRAV 509
Cdd:TIGR00917 747 LdfkrtedkrvdcfpciKTSKSSISAEKGSGQRKAGLltryfkEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIG 826
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 510 LNTAKILPLETPIRKPNRIIEE--TVWKEFYPVTVIVNSPVDISNANAL------------RAFDNL----------VHD 565
Cdd:TIGR00917 827 LDQQIVLPQDSYLQIYFASLTPllEVGPPFYIVIKGDYNYTDFESQNKLctmggcdkdsivNVFNNLsyiakpasswLDD 906
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 566 FESMEKCRGSEYTISPIRDyqtYFYGVG----AEDFDYEEETVKNTSHSLDFSKLTGFL-ANPIYKHHKGGLKLnFSNPV 640
Cdd:TIGR00917 907 YLVWLSPQASCCCRKFTNG---TFCNGPdpqcFRCADLSSDAQGRPSTTQFKEKLPWFLnALPSADCAKGGHAA-YSSAV 982
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 641 PIRKVQLIFAYENVTSW-------DERIQIMQDWRTIASS---HVALNVSVWNVNAMFVDQMLSLKGLAISNALVTLGCM 710
Cdd:TIGR00917 983 DLQGYATIIQASSFRTYhtplntqVDFINAMRAAQEFAAKvsrSSKMEVYPYSVFYVFFEQYLTIWKTAIINLSIALGAI 1062
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 711 AAVCVVFIR-NPLSVGLATASILSISIGVTGYLCFWDLDLDPVTLCAVIVSIGMSVDFVAHVACHYQVRYKefeekgvlk 789
Cdd:TIGR00917 1063 FIVCLFLLQlNALSVVNLIMSVGMAVVFCVGIMHLWSISLNAVSVVNSVMHKGIAIEFCTHINAQFSTGKH--------- 1133
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17508525 790 riemktpESRvVNSLSNVLWPMVQSASS-----TLLCVLPLGILQNYLPMVF-VKTILLVVIWGMFHGLVLLPCILAQF 862
Cdd:TIGR00917 1134 -------FSR-NHRAKEALGGMGSSVFSgitltKLVGVVVLGFSRSEIFVVYyFRMYLALVLLGFLHGLVFLPVLLSVL 1204
|
|
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
295-862 |
5.61e-18 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 89.56 E-value: 5.61e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 295 IVGIVSMIIFIFCTVsisasyygyFSWRI----GLIALACLLVPILAILTAFGINNMLGNRTNSP-MMIMPFLINGIGVN 369
Cdd:TIGR00918 403 VSGYLLMLAYACLTM---------LRWDCaksqGSVGLAGVLLVALSVAAGLGLCALLGISFNAAtTQVLPFLALGVGVD 473
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 370 DAFLTLQNWLQHSPDLPSGKRLGYMLAEAGPSITTTTLTNVIVFLIGWMNPTEEMSIFCLGCAISLLLAYVYTLTFFCPV 449
Cdd:TIGR00918 474 DVFLLAHAFSETGQNIPFEERTGECLKRTGASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAI 553
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 450 LVL----------------------------------------------------------------------------- 452
Cdd:TIGR00918 554 LSLdlrrredrrldifccffspcsarviqiepqayadgsappvysshmqstvqlrteydpgtqhyyttneprshlsvqps 633
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 453 --LLSERVNEPSK---LEGTFNKVLGFYAKIICSRWTFA------------------LLIIGSLVYWGFGIYGTLGIRAV 509
Cdd:TIGR00918 634 dpLSCQSPDIAGStrdLLSQFEDSKAACLSLPCARWTLAtfaekhyapfllqswakvVVIFLFLALLGLSLYGTTRVQDG 713
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 510 LNTAKILPLETpiRKPNRIIEETVWKEFYPVTVIVNSPVDIsnANALRAFDNLVHDFESMEKCRGSEYTISPiRDYQTYF 589
Cdd:TIGR00918 714 LDLTDIVPRDT--NEHDFLDAQFRYFSFYNMYAVTQGNFDY--PTQQQLLYDLHQSFSSVKYVLKEDNGQLP-RMWLHYF 788
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 590 --YGVGAED-FDYEEETVKNTSHS------------------------LDFSKLT------------------------- 617
Cdd:TIGR00918 789 rdWLQGLQKaFDEDWRDGRITKENyrngsddavlaykllvqtghrdkpVDKEQLTtqrlvnadgiinpnafyiylsawvs 868
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 618 ----GFLAN--------PIYKHHKG---GLKLNFSNPVPIRKVQLIFAYENVTSWDERIQIMQDWRTIASSHVALNVSVW 682
Cdd:TIGR00918 869 ndpvAYAASqaniyphpPEWLHDKNdydPENLRIPAAEPLEYAQFPFYLNGLRETSQFVEAIEHVRAICNNYEGFGLPSY 948
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 683 --NVNAMFVDQMLSLKG-LAISNALVtLGCMAAVCVVFIRNPLSVGLATASILSISIGVTGYLCFWDLDLDPVTLCAVIV 759
Cdd:TIGR00918 949 psGYPFLFWEQYMGLRHwLLLSISVV-LACTFLVCALLLLNPWTAGLIVLVLALMTVELFGMMGLLGIKLSAIPVVILIA 1027
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 760 SIGMSVDFVAHVAChyqvrykefeekGVLKRIEMKtpESRVVNSLSNVLWPMVQSASSTLLCVLPL-GILQNYLPMVFVK 838
Cdd:TIGR00918 1028 SVGIGVEFTVHIAL------------GFLTAIGDR--NRRAVLALEHMFAPVLDGALSTLLGVLMLaGSEFDFIVRYFFA 1093
|
730 740
....*....|....*....|....
gi 17508525 839 TILLVVIWGMFHGLVLLPCILAQF 862
Cdd:TIGR00918 1094 VLAVLTCLGVLNGLVLLPVLLSMF 1117
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
322-452 |
5.93e-18 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 81.48 E-value: 5.93e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 322 RIGLiALACLLVPILAILTAFGINNMLGNRTNS-PMMIMPFLINGIGVNDAFLTLQNWLQHSPDLPSGKRLGYMLAEAGP 400
Cdd:pfam12349 5 KFGL-GLAGVIIVLASVASSLGLCAYFGLPLTLiISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDVSERIAEALGEVGP 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 17508525 401 SITTTTLTNVIVFLIGWMNPTEEMSIFCLGCAISLLLAYVYTLTFFCPVLVL 452
Cdd:pfam12349 84 SITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSL 135
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
241-462 |
1.59e-11 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 68.35 E-value: 1.59e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 241 DTDKLNKWELAVYNYATGYSALEGddhlVEINVIGAEVVDTEMNKD-AQKMVPYFIVGIVsmIIFIFCTVSisasyygYF 319
Cdd:COG1033 561 DSEEIKALVEEVRAFLAENFPPDG----VEVTLTGSAVLFAAINESvIESQIRSLLLALL--LIFLLLLLA-------FR 627
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 320 SWRIGLIALACLLVPIL---AILTAFGIN-NMlgnrtnSPMMIMPFLInGIGVNDAFLTLQNWLQH-SPDLPSGKRLGYM 394
Cdd:COG1033 628 SLRLGLISLIPNLLPILltfGLMGLLGIPlNI------ATAVVASIAL-GIGVDYTIHFLSRYREErRKGGDLEEAIRRA 700
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17508525 395 LAEAGPSITTTTLTNVIVFLIGWMNPTEEMSIFCLGCAISLLLAYVYTLTFFcPVLVLLLSERVNEPS 462
Cdd:COG1033 701 LRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLL-PALLLLLDPRIAKKR 767
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
297-859 |
3.19e-10 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 64.09 E-value: 3.19e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 297 GIVSMIIFIFCTVSIsasYYGYFSWRIGLIALACLLvpiLAILTAFGINNMLG-NRTNSPMMIMPFLInGIGVnDAFLTL 375
Cdd:TIGR00921 196 GTTMAISGILVVLVL---LLDFKRWWRPLLPLVIIL---FGVAWVLGIMGWLGiPLYATTLLAVPMLI-GVGI-DYGIQT 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 376 QNWLQHSPDLpsGKRLGYML----AEAGPSITTTTLTNVIVFLIGWMNPTEEMSIFCLGCAISLLLAYVYTLTFFCPVLV 451
Cdd:TIGR00921 268 LNRYEEERDI--GRAKGEAIvtavRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALLQ 345
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 452 LL----------LSERVNEPSKLEGTFNKVLGFyakIICSRWTfalLIIGSLVYWGFGIYGTLGIRAVLNTAKILPLETP 521
Cdd:TIGR00921 346 SIdigrekvkkeIIAIGGKSSEIEEELSKVLSI---TVRHPVP---ALVAALIITGLGLYGAAGIKPEVNIEKFIPQDLP 419
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 522 IRKPNRIIEETVWKEFYPVTVIVNSpVDISNANALRAFDNLVHDfESMEKCRGSEYTISPIRDYQTYFYGVGAEDFDYEE 601
Cdd:TIGR00921 420 SLQARKVIESHMGGSHDFATILVKA-DDVRDPELVRFMDELSRD-IKATGVAARVFGAPSIIDLVKEVEGLPAPERSALE 497
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 602 ETVKntshSLDFSKLTGflanpiykhhkGGLKLNFSnpvpirKVQL-IFAYENVTSWDERIQIMQDWRTIASSHVALNvS 680
Cdd:TIGR00921 498 PIPE----DEEGGYISG-----------GQIKVAVI------QVQLkQGEPKVQGRKILRDVQHEHPPPGVKVGVTGL-P 555
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 681 VwnVNAMFVDQMLSlkGLAISNALVTLGCMAAVCVVFiRNPLSVGLATASILSISIGVTGYLCFWDLDLDPVTLCAVIVS 760
Cdd:TIGR00921 556 V--AFAEMHELVNE--GMRRMTIAGAILVLMILLAVF-RNPIKAVFPLIAIGSGILWAIGLMGLRGIPSFLAMATTISII 630
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 761 IGMSVDFVAHVACHYqvrykeFEEKGVLkriemkTPESRVVNSLSNVLWPMVQSASSTL-----LCVLPLGILQNylpmv 835
Cdd:TIGR00921 631 LGLGMDYSIHLAERY------FEERKEH------GPKEAITHTMERTGPGILFSGLTTAggflsLLLSHFPIMRN----- 693
|
570 580
....*....|....*....|....
gi 17508525 836 FVKTILLVVIWGMFHGLVLLPCIL 859
Cdd:TIGR00921 694 FGLVQGIGVLSSLTAALVVFPALL 717
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
47-452 |
1.56e-05 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 48.68 E-value: 1.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 47 GKIIGRFPI-AFIIATVIMCSGGLGTIGLELKDNVrDGYTPKN--SLSRLENrLYREFlssEGDPVMTTVLMTAKDGGSM 123
Cdd:TIGR00921 376 LSITVRHPVpALVAALIITGLGLYGAAGIKPEVNI-EKFIPQDlpSLQARKV-IESHM---GGSHDFATILVKADDVRDP 450
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 124 HRIKYLEEaqrqwlyISKNLSADVGNGEFMKFGDFCGHYCQANDIIGYFLDAYKTKSADPKmDGYqlnypittVMGYQLH 203
Cdd:TIGR00921 451 ELVRFMDE-------LSRDIKATGVAARVFGAPSIIDLVKEVEGLPAPERSALEPIPEDEE-GGY--------ISGGQIK 514
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 204 LERNFFGVTvnQSDPvtniqsmKVLTLPVLSEVRTFEdtdklnkWELAVYNYATGYSALEGDDHlveinvigaEVVDTEM 283
Cdd:TIGR00921 515 VAVIQVQLK--QGEP-------KVQGRKILRDVQHEH-------PPPGVKVGVTGLPVAFAEMH---------ELVNEGM 569
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 284 NKdaQKMVPYFIVGIVSMIIFIFCTVSISasyygyfswriGLIALacllvpILAILTAFGINNMLGNRTNSPMMIMPFLI 363
Cdd:TIGR00921 570 RR--MTIAGAILVLMILLAVFRNPIKAVF-----------PLIAI------GSGILWAIGLMGLRGIPSFLAMATTISII 630
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 364 NGIGVNDAFLTLQNWLQHSPDLPSGKRLGYMLAEAGPSITTTTLTNVIVFLIGWMNPTEEMSIFCLGCAISLLLAYVYTL 443
Cdd:TIGR00921 631 LGLGMDYSIHLAERYFEERKEHGPKEAITHTMERTGPGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAAL 710
|
....*....
gi 17508525 444 TFFCPVLVL 452
Cdd:TIGR00921 711 VVFPALLVL 719
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
469-863 |
2.17e-05 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 48.32 E-value: 2.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 469 NKVLGFYAKIICS-RWTFALLIIGSLVYWGFGIyGTLGIRAvlNTAKILPLETPIRKPNRIIEETVwKEFYPVTVIVNSP 547
Cdd:COG1033 1 ERLMERLARFILRhRKLVLLLFLLLTLLLAYGA-PKLEVDT--DFESLLPEDDPSVQAYDEFEEEF-GGDDTVVVAVEGK 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 548 VDISNANALRAFDNLVHDFESMEkcrGSEYTISPIRDYQTYFYGVGAEDFDYEEETVKNTSHSLDfSKLTGFLANPIYKh 627
Cdd:COG1033 77 DDIFTPETLEALRELTEELEEIP---GVDSVTSLTNVRATEGTEDGLTVEPLIPDELPASPEELA-ELREKVLSSPLYV- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 628 hkgGLKLNfsnpvPIRKVQLIFAY---ENVTSWDERIQIMQDWRTIASSHVALNVSV----------WNVNAMFVDQMLS 694
Cdd:COG1033 152 ---GRLVS-----PDGKATLIVVTldpDPLSSDLDRKEVVAEIRAIIAKYEDPGVEVyltgfpvlrgDIAEAIQSDLAIF 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 695 LkglaisnaLVTLGCMAAVCVVFIRNPLSVGLATASILsISIGVT-GYLCFWDLDLDPVTLCAVIVSIGMSVDFVAHVac 773
Cdd:COG1033 224 F--------PLALLLILLLLFLFFRSLRGVLLPLLVVL-LAVIWTlGLMGLLGIPLSPLTILVPPLLLAIGIDYGIHL-- 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 774 hyQVRYKEFEEKGvlkriemKTPESRVVNSLSNVLWPMVQSASSTL-----LCVLPLGILQNylpMVFVKTILLVVIWGM 848
Cdd:COG1033 293 --LNRYREERRKG-------LDKREALREALRKLGPPVLLTSLTTAigflsLLFSDIPPIRD---FGIVAAIGVLLAFLT 360
|
410
....*....|....*
gi 17508525 849 FhgLVLLPCILAQFP 863
Cdd:COG1033 361 S--LTLLPALLSLLP 373
|
|
| 2A060605 |
TIGR00920 |
3-hydroxy-3-methylglutaryl-coenzyme A reductase; [Transport and binding proteins, ... |
395-455 |
2.10e-04 |
|
3-hydroxy-3-methylglutaryl-coenzyme A reductase; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273339 [Multi-domain] Cd Length: 886 Bit Score: 45.23 E-value: 2.10e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17508525 395 LAEAGPSITTTTLTNVIVFLIGWMNPTEEMSIFCLGCAISLLLAYVYTLTFF--CPVLVLLLS 455
Cdd:TIGR00920 161 MAILGPTITLDTVVETLVIGVGTMSGVRRLEVLCCFGCMSVLANYFVFMTFFpaCLSLVLELS 223
|
|
| AcrB |
COG0841 |
Multidrug efflux pump subunit AcrB [Defense mechanisms]; |
296-503 |
3.91e-03 |
|
Multidrug efflux pump subunit AcrB [Defense mechanisms];
Pssm-ID: 440603 [Multi-domain] Cd Length: 1015 Bit Score: 41.24 E-value: 3.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 296 VGIVSMIIFIFCTvsisasyygyfSWRIGLI-ALAcllVPIlAILTAFGINNMLG---NrtnspMMIMPFLINGIG--VN 369
Cdd:COG0841 341 ILLVVLVVFLFLR-----------SWRATLIpAVA---IPV-SLIGTFAVMYLLGfslN-----ILTLFALVLAIGivVD 400
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17508525 370 DAFLTLQNWLQHspdlpsgKRLGYMLAEA--------GPSITTTTLTNVIVFL-IGWMN-PTEE-MSIFCLGCAISLLLA 438
Cdd:COG0841 401 DAIVVVENIERH-------MEEGLSPLEAaikgarevAGAVIASTLTLVAVFLpLAFMGgITGQlFRQFALTVAIALLIS 473
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17508525 439 YVYTLTfFCPVL--VLLLSERVNEPSKLEGTFNKVL----GFYAKI----ICSRWTFALLIIGSLV--YWGFGIYGT 503
Cdd:COG0841 474 LFVALT-LTPALcaRLLKPHPKGKKGRFFRAFNRGFdrltRGYGRLlrwaLRHRKLTLLVALALLAlsVLLFGRLPT 549
|
|
| |
