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Conserved domains on  [gi|392884825|ref|NP_490892|]
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Major facilitator superfamily (MFS) profile domain-containing protein [Caenorhabditis elegans]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 48-386 2.13e-18

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17331:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 382  Bit Score: 86.12  E-value: 2.13e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825  48 GYIQAFGSLCNAFGALAAGQLADTLGAQSMFLLSAVFTAIYYSGISLARSWYAFFFLQILRFGYQLDGTAEMYLATVTTE 127
Cdd:cd17331   38 GYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRLPSVFMHAMQAAQMVVTDLTDP 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 128 SERTSALMRLTIPQAIAMFFGPIVGSKVAAWTSLRTSqFIVGFVLAGTMIPVVMFLLPtthSIPRLASARLRPQDywhmi 207
Cdd:cd17331  118 GERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAA-ALVAAVGSLLSIVLVILLIP---SNTKSKREKEAKES----- 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 208 SKNSALKEGLLIRALLISAYVCYEMISRNF--------------LLRNFMHNTNESAYVLLTMSASL-LAVQFIVMPIVQ 272
Cdd:cd17331  189 ASPPSVFNLKEILRLLRLPGVAFLLLVKLLsglpigmfqsmfslVAMDFFGLTPEENGYLMSYAGVLgMVVQGLLVGPLT 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 273 RTASPKRLLQVSLVALFGSYLAAAFANSFEQMLMITAVQTAAYAVAYAESSTQITTAVELTDLGKATGLASMVQWLTHFI 352
Cdd:cd17331  269 KRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTV 348

                        330       340       350
                 ....*....|....*....|....*....|....
gi 392884825 353 LPIYASQLVEHLHYTFAFYTSALLSVFLFAYISV 386
Cdd:cd17331  349 SPTIGGALLQAYGFPSFGLLGAAINGLLTVYLLL 382
 
Name Accession Description Interval E-value
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 48-386 2.13e-18

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 86.12  E-value: 2.13e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825  48 GYIQAFGSLCNAFGALAAGQLADTLGAQSMFLLSAVFTAIYYSGISLARSWYAFFFLQILRFGYQLDGTAEMYLATVTTE 127
Cdd:cd17331   38 GYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRLPSVFMHAMQAAQMVVTDLTDP 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 128 SERTSALMRLTIPQAIAMFFGPIVGSKVAAWTSLRTSqFIVGFVLAGTMIPVVMFLLPtthSIPRLASARLRPQDywhmi 207
Cdd:cd17331  118 GERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAA-ALVAAVGSLLSIVLVILLIP---SNTKSKREKEAKES----- 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 208 SKNSALKEGLLIRALLISAYVCYEMISRNF--------------LLRNFMHNTNESAYVLLTMSASL-LAVQFIVMPIVQ 272
Cdd:cd17331  189 ASPPSVFNLKEILRLLRLPGVAFLLLVKLLsglpigmfqsmfslVAMDFFGLTPEENGYLMSYAGVLgMVVQGLLVGPLT 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 273 RTASPKRLLQVSLVALFGSYLAAAFANSFEQMLMITAVQTAAYAVAYAESSTQITTAVELTDLGKATGLASMVQWLTHFI 352
Cdd:cd17331  269 KRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTV 348

                        330       340       350
                 ....*....|....*....|....*....|....
gi 392884825 353 LPIYASQLVEHLHYTFAFYTSALLSVFLFAYISV 386
Cdd:cd17331  349 SPTIGGALLQAYGFPSFGLLGAAINGLLTVYLLL 382
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
42-348 4.39e-14

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 72.70  E-value: 4.39e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825  42 MTITDLGYIQAFGSLCNAFGALAAGQLADTLGAQSMFLLSAVFTAIYYSGISLARSWYAFFFLQIL-RFGYQLD-GTAEM 119
Cdd:COG2814   42 ASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLqGLGAGALfPAALA 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 120 YLATVTTESERTSALMRLTIPQAIAMFFGPIVGSKVAAWTSLRTSqFIVGFVLAGTMIPVVMFLLPTTHsiprlASARLR 199
Cdd:COG2814  122 LIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWV-FLVNAVLALLALLLLLRLLPESR-----PAARAR 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 200 PQDYWHMISKNSALKEGLLIRALLISAYVCYEMISRNFLLRNFMHNTNESAYVLLTMSASLLAVQFIVMPIVQRTaSPKR 279
Cdd:COG2814  196 LRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF-GRRR 274

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392884825 280 LLQVSLVALFGSYLAAAFANSFEQMLMITAVQTAAYAVAYAESSTQITTAVELTDLGKATGLASMVQWL 348
Cdd:COG2814  275 LLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
MFS_1 pfam07690
Major Facilitator Superfamily;
42-354 1.34e-08

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 56.27  E-value: 1.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825   42 MTITDLGYIQAFGSLCNAFGALAAGQLADTLGAQSMFLLSAVFTAIYYSGISLARSWYAFFFLQILR--FGYQLDGTAEM 119
Cdd:pfam07690  29 ISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQglGAGALFPAALA 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825  120 YLATVTTESERTSALMRLTIPQAIAMFFGPIVGSKVAAWTSLRTSQFIVGFVLAGTMIPVVMFLLPTTHSIPRLASARLR 199
Cdd:pfam07690 109 LIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARL 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825  200 PQD-YWHMISKNSALkegLLIRALLISAYVCYEMISRNFLLRNFMHNTNESAYVLLTMSASLLAVQFIVMPIVQRTASPK 278
Cdd:pfam07690 189 SLIvAWKALLRDPVL---WLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRR 265

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392884825  279 RLLQVSLVALFGSYLAAAFANSFEQMLMITAVQ---TAAYAVAYAESSTQITTAVELTDLGKATGLASMVQWLTHFILP 354
Cdd:pfam07690 266 RRLLLALLLLILAALGLLLLSLTLSSLWLLLALlllGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
 
Name Accession Description Interval E-value
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 48-386 2.13e-18

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 86.12  E-value: 2.13e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825  48 GYIQAFGSLCNAFGALAAGQLADTLGAQSMFLLSAVFTAIYYSGISLARSWYAFFFLQILRFGYQLDGTAEMYLATVTTE 127
Cdd:cd17331   38 GYLQTTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRLPSVFMHAMQAAQMVVTDLTDP 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 128 SERTSALMRLTIPQAIAMFFGPIVGSKVAAWTSLRTSqFIVGFVLAGTMIPVVMFLLPtthSIPRLASARLRPQDywhmi 207
Cdd:cd17331  118 GERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAA-ALVAAVGSLLSIVLVILLIP---SNTKSKREKEAKES----- 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 208 SKNSALKEGLLIRALLISAYVCYEMISRNF--------------LLRNFMHNTNESAYVLLTMSASL-LAVQFIVMPIVQ 272
Cdd:cd17331  189 ASPPSVFNLKEILRLLRLPGVAFLLLVKLLsglpigmfqsmfslVAMDFFGLTPEENGYLMSYAGVLgMVVQGLLVGPLT 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 273 RTASPKRLLQVSLVALFGSYLAAAFANSFEQMLMITAVQTAAYAVAYAESSTQITTAVELTDLGKATGLASMVQWLTHFI 352
Cdd:cd17331  269 KRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTALGLSHALFSLVRTV 348

                        330       340       350
                 ....*....|....*....|....*....|....
gi 392884825 353 LPIYASQLVEHLHYTFAFYTSALLSVFLFAYISV 386
Cdd:cd17331  349 SPTIGGALLQAYGFPSFGLLGAAINGLLTVYLLL 382
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 48-381 1.19e-16

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 80.31  E-value: 1.19e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825  48 GYIQAFGSLCNAFGALAAGQLADTLGAQSMFLLSAVFTAIYYSGISLARSWYAFFFLQILR-FGYQLDGTAEMYLATVTT 126
Cdd:cd17330   37 GLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDgLTGGNVSVAQAYIADITD 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 127 ESERTSALMRLTIPQAIAMFFGPIVGSKVAAWTSLRTSqFIVGFVLAGTMIPVVMFLLPTthsIPRLasarlrpqdywhm 206
Cdd:cd17330  117 EEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALP-FLVAAALALLNLVLVLFFLPP---LRRL------------- 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 207 isknsalkegLLIRALLISAYVCYEMISRNFLLRNFMHNTNESAYVLLTMSASLLAVQFIVMPIVQRTASPKRLLQVSLV 286
Cdd:cd17330  180 ----------LLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLL 249

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 287 ALFGSYLAAAFANSFEQMLMITAVQTAAYAVAYAESSTQITTAVELTDLGKATGLASMVQWLTHFILPIYASQLVEHLHY 366
Cdd:cd17330  250 LAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGP 329

                        330
                 ....*....|....*
gi 392884825 367 TFAFYTSALLSVFLF 381
Cdd:cd17330  330 GVPFLLAAGLLLIAL 344
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 42-387 3.56e-16

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 79.54  E-value: 3.56e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825  42 MTITDLGYIQAFGSLCNAFGALAAGQLADTLGAQSMFLLSAVFTAIYYSGISLARSWYAFFFLQILR--FGYQLDGTAEM 119
Cdd:cd17325   28 ASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQglASAAVWPAAMA 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 120 YLATVTTESERTSALMRLTIPQAIAMFFGPIVGSKVAAWTSLRTSQFIVGFVLAGTMIPVVMFLLPTTHSIPRLASARLR 199
Cdd:cd17325  108 LIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAAR 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 200 PQDYWHMISKNSALKEGLLIRALLISAYVCYEMISRNFLLRNFMHNTNESAYVLLTMSASLLAVQFIVMPIVQRtASPKR 279
Cdd:cd17325  188 LRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDR-IGRKP 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 280 LLQVSLVALFGSYLAAAFANSFEQMLMITAVQTAAYAVAYAESSTQITTAVELTDLGKATGLASMVQWLTHFILPIYASQ 359
Cdd:cd17325  267 LILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGF 346

                        330       340
                 ....*....|....*....|....*...
gi 392884825 360 LVEHLHYTFAFYTSALLSVFLFAYISVY 387
Cdd:cd17325  347 LYDAFGFATPFLAAAALLLLAAVLFLLL 374
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
42-348 4.39e-14

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 72.70  E-value: 4.39e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825  42 MTITDLGYIQAFGSLCNAFGALAAGQLADTLGAQSMFLLSAVFTAIYYSGISLARSWYAFFFLQIL-RFGYQLD-GTAEM 119
Cdd:COG2814   42 ASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLqGLGAGALfPAALA 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 120 YLATVTTESERTSALMRLTIPQAIAMFFGPIVGSKVAAWTSLRTSqFIVGFVLAGTMIPVVMFLLPTTHsiprlASARLR 199
Cdd:COG2814  122 LIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWV-FLVNAVLALLALLLLLRLLPESR-----PAARAR 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 200 PQDYWHMISKNSALKEGLLIRALLISAYVCYEMISRNFLLRNFMHNTNESAYVLLTMSASLLAVQFIVMPIVQRTaSPKR 279
Cdd:COG2814  196 LRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF-GRRR 274

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392884825 280 LLQVSLVALFGSYLAAAFANSFEQMLMITAVQTAAYAVAYAESSTQITTAVELTDLGKATGLASMVQWL 348
Cdd:COG2814  275 LLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 42-382 4.96e-10

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 60.70  E-value: 4.96e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825  42 MTITDLGYIQAFGSLCNAFGALAAGQLADTLGAQSMFLLSAVFTAIYYSGISLARSWYAFF-FLQILRFGYQLDGTA-EM 119
Cdd:cd17329   32 LSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAiALVLTGFGGGLFEPAsEA 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 120 YLATVTTESERTSALMRLTIPQAIAMFFGPIVGSkvaawtSLRTSQFIVGFVLAGTMIPVVMFLLPTThsIPRLASARLR 199
Cdd:cd17329  112 MIADVTTPENRTRAFSLLYWAINLGVAIGPLLGG------LLLLYSFRLLFLAAAVLFLLAALVLLFL--LPETRPKRRA 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 200 PQDYWHMISKNSALKEGLLIraLLISAYVCYEMISRNF-----LLRNFMHNTNESAYVLLTMSASLLAV--QFIVMPIVQ 272
Cdd:cd17329  184 AEKTEILRGYKIVLRDRAFL--LFLLASFLISLIYFQLestlpVYVVEILGLGESLLGLLLALNALLIVllQFPVARLVE 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 273 RTaSPKRLLQVSLVALFGSYLAAAFANSFEQMLMITAVQTAAYAVAYAESSTQITTAVELTDLGKATGLASMVQWLTHFI 352
Cdd:cd17329  262 RF-RLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAI 340

                        330       340       350
                 ....*....|....*....|....*....|
gi 392884825 353 LPIYASQLVEHLHYTFAFYTSALLSVFLFA 382
Cdd:cd17329  341 GPLVGGLLLDLLGPGLPWLILAALGLIAAA 370
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 13-381 7.04e-09

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 57.05  E-value: 7.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825  13 LCLVFGLWHFATQWTTTLLSFLQwdTEEVMTITDLGYIQAFGSLCNAFGALAAGQLADTLGAQSMFLLSAVFTAIYYSGI 92
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALL--QSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825  93 SLARSWYAFFFLQILR-FGYQL-DGTAEMYLATVTTESERTSALMRLTIPQAIAMFFGPIVGSKVAAWTSLRTSQ----F 166
Cdd:cd06174   79 AFAPSFWLLLLGRFLLgLGSGLiDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAvfliA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 167 IVGFVLAGTMIPVVMFLLPTTHSIPRLASARLRPQDYWHMISKNSALKEGLLIRALLISAYVCYEMISRNFLLRNFMHNT 246
Cdd:cd06174  159 AALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSV 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 247 NESAYVLLTMSASLLAVQFIVMPIVQRTASPKRLLQVSLVALFGSYLAAAFANSFEQMLMITAVQTAAYAVAYAESSTQI 326
Cdd:cd06174  239 AVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALI 318

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 392884825 327 TTAVELTDLGKATGLASMVQWLTHFILPIYASQL-VEHLHYTFAFYTSALLSVFLF 381
Cdd:cd06174  319 AELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATFGLTGAFLVLAVLLLLAA 374
MFS_1 pfam07690
Major Facilitator Superfamily;
42-354 1.34e-08

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 56.27  E-value: 1.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825   42 MTITDLGYIQAFGSLCNAFGALAAGQLADTLGAQSMFLLSAVFTAIYYSGISLARSWYAFFFLQILR--FGYQLDGTAEM 119
Cdd:pfam07690  29 ISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQglGAGALFPAALA 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825  120 YLATVTTESERTSALMRLTIPQAIAMFFGPIVGSKVAAWTSLRTSQFIVGFVLAGTMIPVVMFLLPTTHSIPRLASARLR 199
Cdd:pfam07690 109 LIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARL 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825  200 PQD-YWHMISKNSALkegLLIRALLISAYVCYEMISRNFLLRNFMHNTNESAYVLLTMSASLLAVQFIVMPIVQRTASPK 278
Cdd:pfam07690 189 SLIvAWKALLRDPVL---WLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRR 265

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392884825  279 RLLQVSLVALFGSYLAAAFANSFEQMLMITAVQ---TAAYAVAYAESSTQITTAVELTDLGKATGLASMVQWLTHFILP 354
Cdd:pfam07690 266 RRLLLALLLLILAALGLLLLSLTLSSLWLLLALlllGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 59-378 5.40e-08

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 54.50  E-value: 5.40e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825  59 AFGALAAGQLADTLGAQSMFLLSAVFTAIYYSGISLARSwyaFFFLQILRFGYQLDGTAEMYLATVT-----TESERTSA 133
Cdd:cd17474   48 AVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDS---FALLLAGRALQGIGAAGLGPLALTLigdlfEGGERAKA 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 134 LMRLTIPQAIAMFFGPIVGSKVAAWtSLRTSqFIVGFVLAGTMIPVVMFLLPTTHSIPRLASARLRPQdyWHMISKNSAL 213
Cdd:cd17474  125 MGLYEAALGLGIAVGPLLGGLLAAI-SWRYP-FFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRD--LKKALRGRGL 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 214 KEGLLIRALLISAYVCYEMISRNFLLRNFMHNTNESAYVLLTMSASLLAVQFIVMPIVQRTASPKRLLQVSLVALFGSYL 293
Cdd:cd17474  201 LTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLL 280

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 294 AAAFANSFEQMLMITAVQTAAYAVAYAESSTQITTAVELTDLGKATGLASMVQWLTHFILPIYASQLVEHLHYTFAFYTS 373
Cdd:cd17474  281 LLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVG 360


                 ....*
gi 392884825 374 ALLSV 378
Cdd:cd17474  361 AAIAL 365
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 66-387 2.18e-07

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 52.65  E-value: 2.18e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825  66 GQLADTLGAQSMFLLSAVFTAIYYSGISLARSWYAFFFLQILR---FGYQLDGTAEMylATVTTESERTSALMRLTIPQA 142
Cdd:cd17391   57 GRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQgvfSGYVPNATALI--ASQTPKEKSGWALGTLSTGVV 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 143 IAMFFGPIVGSKVAAWTSLRTSQFIVGFVLAGTMIpVVMFLLPTTHSiPRLASARLRPQDYWHMISKNSALKEGLLIRAL 222
Cdd:cd17391  135 AGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFL-LTLFFVKEDFK-PVEKKKMVSTKEVWNSVPNPSLLISLFVTTFI 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 223 LISAYVCYEMISRNFlLRNFMHNTNESAYVL-LTMSASLLAvQFIVMPIVQRTAS---PKRLLQVSLVALFGSYLAAAFA 298
Cdd:cd17391  213 IQLANQSIEPILTLY-IRQLMGDASNLAFISgLVFSATGVS-SLLSAPRLGKLGDrigHHRILLGALLASALLYIPQAFV 290

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 299 NSFEQMLMITAVQTAAYAVAYAESSTQITTAVELTDLGKATGLASMVQWLTHFILPIYASQLVEHLHYTFAFYTSALLsv 378
Cdd:cd17391  291 QTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTALL-- 368


                 ....*....
gi 392884825 379 FLFAYISVY 387
Cdd:cd17391  369 VLLNAIWSF 377
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 6-183 1.18e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 50.27  E-value: 1.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825   6 KQKVMFTLCLVFGLWHFATQWTTTLLSFLqWDTEEVMTITDLGYIQAFGSLCNAFGALAAGQLADTLGAQSMFLLSAVFT 85
Cdd:cd17325  197 RDRRLLALFLAIFVLAFAFGALEPFLPLY-AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLS 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825  86 AIYYSGISLARSWYAFFFLQILR-FGYQLDGTAEM-YLATVTTESERTSALMRLTIPQAIAMFFGPIVGSKVAAWTSLRT 163
Cdd:cd17325  276 AVALLLLPLATSFWLLLLLLALLgLGLGLVFPATLaLLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFAT 355

                        170       180
                 ....*....|....*....|
gi 392884825 164 SQFIVGFVLAGTMIPVVMFL 183
Cdd:cd17325  356 PFLAAAALLLLAAVLFLLLR 375
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
1-301 3.66e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 48.70  E-value: 3.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825   1 MSLEKKQKVMFTLCLVFGLWHFATQWTTTLLSFLQWDTEevMTITDLGYIQAFGSLCNAFGALAAGQLADTLGAQSMFLL 80
Cdd:COG0738    1 MSKKNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFG--LSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825  81 SAVFTAIYYSGISLARSWYAFFFLQILrFGY---QLDGTAEMYLATVTTESERTsalmRLTIPQA---IAMFFGPIVGSK 154
Cdd:COG0738   79 GLLLMALGLLLFALAPSYPLLLLALFL-LGLglgLLDVAANPYVAALGPETAAS----RLNLLHAffsLGALLGPLLGGL 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 155 VAAW---TSLRTSQFIVGFVLAGTMIPVVMFLLPTTHSIPRLASARLRpqdywhmiSKNSALKEGLLIR-ALLISAYVCY 230
Cdd:COG0738  154 LILLglsLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAA--------SLKSLLKNPRLLLgGLAIFLYVGA 225

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392884825 231 EMI----SRNFLLRNFMHNTNESAYVLLTMSASLLAVQFIVMPIVQRtASPKRLLQVSLVALFGSYLAAAFANSF 301
Cdd:COG0738  226 EGAigdwLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKR-FGPVRLLRLSALLAAVGLLLALLAPGP 299
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
237-392 4.36e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 48.43  E-value: 4.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 237 FLLRNFMHNTNESAYVLLTMSASLLAVQFIVMPIVQRTaSPKRLLQVSLVALFGSYLAAAFANSFEQMLMITAVQTAAYA 316
Cdd:COG2814   35 LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF-GRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAG 113

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 392884825 317 VAYAESSTQITTAVELTDLGKATGLASMVQWLTHFILPIYASQLVEHLHYTFAFYTSALLSVFLFAYISVYGKETP 392
Cdd:COG2814  114 ALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESR 189
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 63-383 1.99e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 46.43  E-value: 1.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825  63 LAAGQLADTLGAQSMFLLSAVFTAIYYSGISLARSWYAFFFLQILR-FGYQLDGTAEMYLATVTTESERTSALMRLT-IP 140
Cdd:cd17489   49 PFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHgIGWGAFTTAAATLVADIIPPSRRGEGIGYYgLA 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 141 QAIAMFFGPIVGSKVAAWTSLRtSQFIVGFVLAGTMIpVVMFLLPTTHSIPRLASARLRPQDYWHMisknsaLKEGLLIR 220
Cdd:cd17489  129 TTLAMALGPALGLFLYQHLGFA-VLFIVAAVLALLAL-LLVFLVKDPPPVAAEEAEAGTRAFRRLV------EKKVLPPA 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 221 ALLISAYVCYEMISrNFL-LRNFMHNTNESAYVLLTMSASLLAVQFIVMPIVQRTAsPKRLLQVSLVALFGSYLAAAFAN 299
Cdd:cd17489  201 LILFLASIAYGAIS-TFLpLYAAERGISNAGLFFTVYAIALLLSRPFSGKLSDRKG-PKTVIIPGLLLLALGLLLLSFAG 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 300 SFEQMLMITAVQTAAYAVAYAESSTQITTAVELTDLGKATGLASMVQWLTHFILPIYASQLVEHLHYTFAFYTSALLSVF 379
Cdd:cd17489  279 SPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLL 358


                 ....
gi 392884825 380 LFAY 383
Cdd:cd17489  359 ALVL 362
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
42-382 3.80e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 45.64  E-value: 3.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825  42 MTITDLGYIQAFGSLCNAFGALAAGQLADTLGAQSMFLLSAVFTAIYYSGISLARSWYAFFFLQILrFGYqldGTAEMYL 121
Cdd:COG2223   37 LSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLL-LGI---GGGGSFA 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 122 ATVTT------ESERTSALMRLTIPQAIAMFFGPIVGSKVAAWTSLRTSQFIVGFVLAGTMIPVVMFLLPTTHSIPRLAS 195
Cdd:COG2223  113 VGIALvskwfpPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAK 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 196 ARLRPQdywhmiskNSALKEG--LLIRALLISAYVCYEMISRNF--LLRNFMHNTNESAyVLLTMSASLLAV--QFIVMP 269
Cdd:COG2223  193 ASLRDQ--------LEALRDPrfWLLSLLYFGTFGSFIGFSSWLppYLVDQFGLSAATA-GLLAALFALLGAlgRPLGGW 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 270 IVQRTASPKRLLQVSLVALFGSYLAAAFANSFEQMLMITAVQTAAYAVAYAESSTQITTAVELTDLGKATGLASMVQWLT 349
Cdd:COG2223  264 LSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLG 343

                        330       340       350
                 ....*....|....*....|....*....|....
gi 392884825 350 HFILPIYASQLVEHLH-YTFAFYTSALLSVFLFA 382
Cdd:COG2223  344 GFLGPLLFGALLDATGsYTAAFLVFAVLALVALV 377
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 42-378 6.08e-05

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 44.91  E-value: 6.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825  42 MTITDLGYIQAFGSLCNAFGALAAGQLADTLGAQSMFLLSAVFTAIYYSGISLARSWYAFFFLQILR--FGYQLDgTAEM 119
Cdd:cd17390   28 ASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLgiFKHTQS-LCKA 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 120 YLATVTTESERTSALMRLTIPQAIAMFFGPIVGSKVAAWTSlrtSQFIVGFVLAgtmipvVMFLLptthsipRLASARLR 199
Cdd:cd17390  107 YLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAETDG---GFYYVALLCS------AIFIL-------NAGLVWFL 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 200 PQDYWHMisknsalkegLLIRALL-ISAYVCYEMISRnFLLRNFMHNTNESAYVLLTMSASLLAVQFIVMPIVQ--RTAS 276
Cdd:cd17390  171 LSKLWDL----------LLVRFLMgFSVLLFRSNFSL-YLEERFDLSPKTIGYLISYSGVLGALSGFLVGRILKlyKNNE 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 277 PKRLLQVSLVALFgSYLAAAFANSFEQMLMITAVQTAAYAVAYAESSTQITTAVELTDLGKATGLASMVQWLTHFILPIY 356
Cdd:cd17390  240 YLLLLHSFILLAL-SLLGLALAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRGKSKERGTLLGVGQSVTSLARILAPLL 318

                        330       340
                 ....*....|....*....|..
gi 392884825 357 ASQLVEhLHYTFAFYTSALLSV 378
Cdd:cd17390  319 SGLLQE-FSVSGPGLLGAVLAL 339
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 45-384 7.16e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 44.53  E-value: 7.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825  45 TDLGYIQAFGSLCNAFGALAAGQLADTLG---------AQSMFLLSAVFTAIYYSGISLarsWYAFFFLQILRFGYQLDG 115
Cdd:cd06173   34 LLVGLVLAAFFLPFLLFSPFAGVLADRFDrrrlliladLLRALLAAVLALLALLGSLSL---WLLLVLAFLLGIASAFFG 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 116 TAEM-YLATVTTESERTSALMRLTIPQAIAMFFGPIVGSKVAAWTSLRTSQFIVGFVLAGTMIpvVMFLLPTTHSIPRLA 194
Cdd:cd06173  111 PARQaLLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSAL--LLLFIRRPPPAAPGE 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 195 SARLRPQDYWHMIS--KNSALKEGLLIRALLISAYVCYEMISRNFLLRNFMHNTNESAYVLLTMSASLLAVQFIVMPIVQ 272
Cdd:cd06173  189 SSSLLLRDLREGLRylRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLS 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 273 RTASPKRLLQVSLVALFGSYLAAAFANSFEQMLMITAVQTAAYAVAYAESSTQITTAVELTDLGKATGLASMVQWLTHFI 352
Cdd:cd06173  269 KRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPL 348

                        330       340       350
                 ....*....|....*....|....*....|..
gi 392884825 353 LPIYASQLVEHLHYTFAFYTSALLSVFLFAYI 384
Cdd:cd06173  349 GALLAGLLADALGLSAVFLLAGALLLLAALLL 380
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
8-392 3.26e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 42.55  E-value: 3.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825   8 KVMFTLCLVFGLWHFATQWTTTLLSFLQwdTEEVMTITDLGYIQAFGSLCNAFGALAAGQLADTLGAQSMFLLSAVFTAI 87
Cdd:COG2271   10 RILALLFLAYFLNYLDRSNLSVAAPPLQ--ADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825  88 YYSGISLARSWYAFFFLQILrFGYqldGTAEMYLATVTT------ESERTSALMRLTIPQAIAMFFGPIVGSKVAAWTSL 161
Cdd:COG2271   88 ATLLFGFATSFWQLLLLRFL-LGL---GEAGFFPAALKLiaewfpPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGW 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 162 RTSQFIVGFVLAGTMIPVVMFLlptthsiprlasarlrpqdywhmisknsalkegLLIRALLISAYVCYEMISRNFLLRN 241
Cdd:COG2271  164 RAAFLILGLPGLLLALLRFWLL---------------------------------ALAYFLVYFALYGFLTWLPTYLVEV 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 242 FMHNTNESAYVLLTMSASLLAVQFIVMPIVQRT-ASPKRLLQVSLVALFGSYLAAAFANSFEQMLMITAVQTAAYAVAYA 320
Cdd:COG2271  211 RGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLgRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFG 290

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392884825 321 ESSTQITTAVELTDLGKATGLASMVQWLTHFILPIYASQLVEHLHYTFAFYTSALLSVFLFAYISVYGKETP 392
Cdd:COG2271  291 LLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 42-182 4.41e-04

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 42.21  E-value: 4.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825  42 MTITDLGYIQAFGSLCNAFGALAAGQLADT-LGAQSMFLLSAVFTAIYYSGISLARSWYAFFFLQILR-FGYQLDGTAEM 119
Cdd:cd17490  227 ASSFQLGLLSIIYLLPNALASLLSGTLFYKkLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNgFGTGILFPLLM 306

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392884825 120 YLATVTTESERTSALMRLTipQAI---AMFFGPIVGSKVAAWTSLRTSQFIVGFV-LAGTMIPVVMF 182
Cdd:cd17490  307 SLSIEGVPAEQRSTAMGFF--QAIyalGMFLGPVLVGIISEAFGLQTGFFVIGVIaLLAAILSLAYY 371
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 278-395 6.86e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 41.41  E-value: 6.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 278 KRLLQVSLVALFGSYLAAAFANSFEQMLMITAVQTAAYAVAYAESSTQITTAVELTDLGKATGLASMVQWLTHFILPIYA 357
Cdd:cd17325   61 KRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLG 140

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 392884825 358 SQLVEHLHYTFAFYTSALLSVFLFAYISVYGKETPNRS 395
Cdd:cd17325  141 GLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPP 178
MFS_1 pfam07690
Major Facilitator Superfamily;
237-394 1.34e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 40.48  E-value: 1.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825  237 FLLRNFMHNTNESAYVLLTMSASLLAVQFIVMPIVQRTaSPKRLLQVSLVALFGSYLAAAFANSFEQMLMITAVQTAAYA 316
Cdd:pfam07690  22 LLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF-GRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAG 100

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392884825  317 VAYAESSTQITTAVELTDLGKATGLASMVQWLTHFILPIYASQLVEHLHYTFAFYTSALLSVFLFAYISVYGKETPNR 394
Cdd:pfam07690 101 ALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESK 178
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 266-386 8.33e-03

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 37.94  E-value: 8.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825 266 IVMPIVQ---RTASPKRLLQVSLVALFGSYLAAAFANSFEQMLMITAVQTAAYAVAYAESSTQITTAVELTDLGKATGLA 342
Cdd:cd17503   46 IMIPLSGwlaDRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLV 125

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 392884825 343 SMVQWLTHFILPIYASQLVEHLHYTFAFYTSALLSVFLFAYISV 386
Cdd:cd17503  126 GLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPL 169
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 5-108 9.00e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 37.91  E-value: 9.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392884825   5 KKQKVMFTLCLVFGLWHFATqwTTTLLSFLQWDTEEV-MTITDLGYIQAFGSLCNAFGALAAGQLADTLGAQSMFLLSAV 83
Cdd:cd17471  196 PVNRRLLLLFAAFTLLFAAN--SMYIIAMPLYVTNELgGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFL 273

                         90       100
                 ....*....|....*....|....*
gi 392884825  84 FTAIYYSGISLARSWYAFFFLQILR 108
Cdd:cd17471  274 AGVLFYLGLALATSLWQLIALQLLN 298
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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