|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
30-453 |
3.27e-59 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 201.31 E-value: 3.27e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 30 ALLISAACVVFGLMRTCFGMAMVDIVRSGNGTFHPDLHM------------EWSGDEQANIHTSFYIGAFIAVFPSEFLA 97
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTSTdkdtlpveapefDWSEKTQGIILSSFFYGYILTQIPGGYLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 98 KKLGPKNLLSFALLLNIFGSLLTPFSAIYlrSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQI 177
Cdd:cd17318 81 EKYGAKRVLGYSILITALLTLLTPLAARG--GYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 178 GIAVSMFLTAKLCQLHffeGWPLVFIVYGLIGAVFLVIWhvrladkpreskyitateltyikggkqrrnraetivratpy 257
Cdd:cd17318 159 GTVIAMPLSGFLCESL---GWPSIFYIFGGLGLLWCLLW----------------------------------------- 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 258 mkIILNGCVCAICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKQRKV-NATA 336
Cdd:cd17318 195 --FFLVLPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGIlSTTT 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 337 VTKVSNAIASFASAIFIVIAAYGPFDSAELVqLSIIVSMAAFSAYVPGYNTSIVTVAPQFTAFISSYAQLYAQIASTLAP 416
Cdd:cd17318 273 VRKLFTSIGFLGPGVFLIALGYLGSNATLAV-VFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISP 351
|
410 420 430
....*....|....*....|....*....|....*...
gi 25141316 417 IVIGRITSHG-TIYEWKCAFYSLAGVLAVTGLIFQIFG 453
Cdd:cd17318 352 LIVGAIVKNDqTIGQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
19-460 |
2.03e-50 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 179.94 E-value: 2.03e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 19 LWTLQSIRFQTALLISAACVVFGLMRTCFGMAMVDIVRSGNGTFHPDLHME------------WSGDEQANIHTSFYIGA 86
Cdd:TIGR00894 10 LPYFCSFRLFLSFLLHICNVIIIAQRICLSLTMVAMVNKENSTDLACLSAEneldniknpnfkWSGALQGLILSSHFYGQ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 87 FIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLLTPFSAIYLRSYfpVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKST 166
Cdd:TIGR00894 90 IIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIAL--VVFCRVIQGLAQGSVSPATHKIIVKWAPPKERSR 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 167 AMAIFTTGNQIGIAVSMFLTAKLCQLHFfeGWPLVFIVYGLIGAVFLVIWHVRLADKPRESKYITATELTYIKGGKQRRN 246
Cdd:TIGR00894 168 LLGMSTSGFQLGTFIFLPISGWLCESWG--GWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINSSLQGQK 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 247 RAETivRATPYMKIILNGCVCAICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADK 326
Cdd:TIGR00894 246 GSTR--QSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADF 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 327 VKQRKVNA-TAVTKVSNAIASFASAIFIViaaYGPFDSAELVQLSIIVSMA-AFSAY-VPGYNTSIVTVAPQFTAFISSY 403
Cdd:TIGR00894 324 LKSSKTLSlTAARKIFNGIGGLGPGIFAY---ALPYLSAAFYLTIIILTLAnAVSSGpLAGVLINSLDLAPRFLGFIKGI 400
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 25141316 404 AQLYAQIASTLAPIVIGRITSHGTIYEWKCAFYSLAGVLAVTGLIFQIFGHGRTEPW 460
Cdd:TIGR00894 401 TGLPGFIGGLIASTLAGNILSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDW 457
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
38-453 |
8.66e-36 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 137.99 E-value: 8.66e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 38 VVFGLmRTCFGMAMVDIV------RSGNGTFHPDLH--------------MEWSGDEQANIHTSFYIGAFIAVFPSEFLA 97
Cdd:cd17381 11 VVYAL-RVNLSVALVDMVnsnstlPSNNSSNACPEHssspsvehnetgkkYDWDAETQGWILGSFFYGYIITQIPGGYLA 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 98 KKLGPKNLLSFALLLNIFGSLLTPFSAIYLRSYfpVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQI 177
Cdd:cd17381 90 SKIGGKLLLGFGILGTAVFTLLTPLAADLGAGY--LIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLTISYAGAQL 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 178 GIAVSMFLTAKLCqlhFFEGWPLVFIVYGLIGAVFLVIWhvrladkpreskyitateltyikggkqrrnraetivratpy 257
Cdd:cd17381 168 GTVVSLPLSGLIC---YYLDWTYVFYIFGAVGLLWFFLW----------------------------------------- 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 258 mkIILNGCVCAICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKQRKV-NATA 336
Cdd:cd17381 204 --IWLVMPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKQNfSTVC 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 337 VTKVSNAIASFASAIFIVIAAY-GPFDSAELVQLSIIVSMAAFSAyvPGYNTSIVTVAPQFTAFISSYAQLYAQIASTLA 415
Cdd:cd17381 282 VRKIFTLIGMIGPAVFLLAAGFtGCNYSLAVAFLTISSTLGGFSA--SGFNINHLDIAPSYAGILLGITNTFATIPGMVG 359
|
410 420 430
....*....|....*....|....*....|....*...
gi 25141316 416 PIVIGRITSHGTIYEWKCAFYSLAGVLAVTGLIFQIFG 453
Cdd:cd17381 360 PVIAKSLTHNNTVEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
26-453 |
3.34e-33 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 129.99 E-value: 3.34e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 26 RFQTALLISAACVVFGLMRTCFGMAMVDIVRsgngtfhpDLHmeWSGDEQANIHTSFYIGAFIAVFPSEFLAKKLGPKNL 105
Cdd:COG2271 8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQA--------DLG--LSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 106 LSFALLLNIFGSLLTPFSaiylRSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFL 185
Cdd:COG2271 78 LAIGLLLWGLATLLFGFA----TSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 186 TAKLCQLHffeGWPLVFIVYGLIGAVFLVIWhvrladkpreskyitateltyikggkqrrnraetivratpymkiilngc 265
Cdd:COG2271 154 LGWLLAAF---GWRAAFLILGLPGLLLALLR------------------------------------------------- 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 266 VCAICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKQRKVNATavtkvsnAIA 345
Cdd:COG2271 182 FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVL-------AIG 254
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 346 SFASAIFIVIAAYgpFDSAELVQLSIIVSMAAFSAYVPGYNTSIVTVAP-QFTAFISSYAQLYAQIASTLAPIVIGRITS 424
Cdd:COG2271 255 LLLAALALLLLAL--LPSPALAIALLFLAGFGLGGAFGLLWALAAELFPkKARGTASGLVNTFGFLGGALGPLLVGYLLD 332
|
410 420
....*....|....*....|....*....
gi 25141316 425 HgtiYEWKCAFYSLAGVLAVTGLIFQIFG 453
Cdd:COG2271 333 A---TGYQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
37-453 |
7.22e-28 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 115.13 E-value: 7.22e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 37 CVVFGlMRTCFGMAMVDIVRsgNGTFHPDLHME-------WSGDEQANIHTSFYIGAFIAVFPSEFLAKKLGPKNLLSFA 109
Cdd:cd17382 9 CISFG-IRCNLGVAIVRMVN--NFTDAYGGKVIvhkaefnWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 110 LLLNIFGSLLTPFSAIYlrSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKL 189
Cdd:cd17382 86 IFVTSTLNMLIPIAARV--HYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGIL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 190 CQlhfFEGWPLVFIVYGLIGAVFLVIWhvrladkpreskyitateltyikggkqrrnraetivratpymkIILNGCVCAI 269
Cdd:cd17382 164 VQ---YVGWSSPFYVYGVFGIIWYMFW-------------------------------------------MLVSMPVYAI 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 270 CACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKV-KQRKVNATAVTKVSNAIASFA 348
Cdd:cd17382 198 IVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLrSRGILSTTAVRKIFNCGGFGM 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 349 SAIFIVIAAYGPFDSAELVQLSIIVSMAAFSayVPGYNTSIVTVAPQFTAFISSYAQLYAQIASTLAPIVIGRITSHGTI 428
Cdd:cd17382 278 EATFLLVVAFSHSPTVAISFLVLAVGFSGFA--ISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPVIVGALTKHKTR 355
|
410 420
....*....|....*....|....*.
gi 25141316 429 YEWKCAFYsLAGVLAVTGLIF-QIFG 453
Cdd:cd17382 356 EEWQYVFL-IASLVHFFGVIFyAIFA 380
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
70-453 |
6.65e-27 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 111.88 E-value: 6.65e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 70 WSGDEQANIHTSFYIGAFIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLLTPFSAIYlrSYFPVAAIRLIMGFGYGFVIP 149
Cdd:cd17380 31 WSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYS--SLPLLILSRILLGLGEGVHFP 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 150 AGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLcqLHFFeGWPLVFIVYGLIGAVFLVIWHvrladkpresKY 229
Cdd:cd17380 109 SMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLL--LEYY-GWPSVFYFFGLLGLLWALVWL----------IY 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 230 ITAteltyikggkqrrnraetivratpymkiilngcVCAICACSFAQSFVLVALVTYLPKYNQIAFkMNLTHNGIWSSLP 309
Cdd:cd17380 176 LPP---------------------------------VWAIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVP 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 310 FFIQMITKLLFAIIADKVKQRKVNATAVTKVSNAIASFASAIFIVIAAYGPFDSAELVQLSIIVSMAAFSayVPGYNTSI 389
Cdd:cd17380 222 WLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQSIGFLGPALFLLLLSHTDSFSLALLCMSVALGLSAFS--SSGVLVNH 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 25141316 390 VTVAPQFTAFISSYAQLYAQIASTLAPIVIGRI-TSHGTiyeWKCAFYSLAGVLAVTGLIFQIFG 453
Cdd:cd17380 300 QDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYIlEATGS---WSLVFVLAAVVNLVGAVVFLLFG 361
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
33-416 |
2.61e-26 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 109.82 E-value: 2.61e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 33 ISAACVVFGLMRTCFGMAMVDIVRSGNGtfhpdlhmeWSGDEQANIHTSFYIGAFIAVFPSEFLAKKLGPKNLLSFALLL 112
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLG---------ISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 113 NIFGSLLTPFSAiylrSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQL 192
Cdd:pfam07690 72 FALGLLLLLFAS----SLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 193 HffeGWPLVFIVYGLIGAVFLVIWHVRlaDKPRESKYITATELTYIKGGKQRRnraetIVRATPYMKIILngcvcaicaC 272
Cdd:pfam07690 148 F---GWRAAFLILAILSLLAAVLLLLP--RPPPESKRPKPAEEARLSLIVAWK-----ALLRDPVLWLLL---------A 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 273 SFAQSFVLVALVTYLPKYNQIaFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKQRKVNATAVtkvsnaiaSFASAIF 352
Cdd:pfam07690 209 LLLFGFAFFGLLTYLPLYQEV-LGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLAL--------LLLILAA 279
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 25141316 353 IVIAAYGPFDSAELVQLSIIVSMAAFSAYVPGYNTSIVTVAP-QFTAFISSYAQLYAQIASTLAP 416
Cdd:pfam07690 280 LGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPkEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
26-448 |
3.05e-23 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 101.11 E-value: 3.05e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 26 RFQTALLISAACVVFGLMRTCFGMAMVDIVRsgngtfhpDLHmeWSGDEQANIHTSFYIGAFIAVFPSEFLAKKLGPKNL 105
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMK--------DLG--LSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKV 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 106 LSFALLLNIFGSLLTPFsaiyLRSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFL 185
Cdd:cd17319 71 LAVSMLLWSLFTALTGF----ATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 186 TAKLCQLHffeGWPLVFIVYGLIGAVFLVIWHVRLadkpreskyitateltyikggkqrrnraetivratpymkiilnGC 265
Cdd:cd17319 147 SGWLLLLF---GWRWAFIIEGLLGLLLAVLWWFYL-------------------------------------------RQ 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 266 VCAICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKqrKVNATAVtkvsnAIA 345
Cdd:cd17319 181 VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLL--RGARRLV-----III 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 346 SFASAIFIVIAAYgPFDSAELVQLSIIVSMAAFSAYVPGYNTSIVTVAPQ-FTAFISSYAQLYAQIASTLAPIVIGRITS 424
Cdd:cd17319 254 GLLLAAVGLLLAY-LTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGeAAATAGGLINSGGNLGGFVAPLLIGYLVD 332
|
410 420
....*....|....*....|....
gi 25141316 425 HGTIYEWkcAFYSLAGVLAVTGLI 448
Cdd:cd17319 333 ATGSYTA--AFLFLAAVALLAALL 354
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
46-449 |
5.02e-23 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 100.96 E-value: 5.02e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 46 CFGMAMVDIVRSGNGTFHPDL--HMEWSGDEQANIHTSFYIGAFIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLLTPFS 123
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALlqSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 124 AiylrSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCqLHFFEGWPLVFI 203
Cdd:cd06174 82 P----SFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILA-SSLGFGWRAVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 204 VYGLIGAVFLVIWHVRLADKPRESKYITATELTYIKGgkqrrnraetivraTPYMKIILNGCVCAICACSFAQSFVLVAL 283
Cdd:cd06174 157 IAAALALLAAILLLLVVPDPPESARAKNEEASSKSVL--------------KLLKRVLKNPGLWLLLLAIFLVNLAYYSF 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 284 VTYLPKYNQIAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKQRKVnatavtkvsNAIASFASAIFIVIAAYGPFDS 363
Cdd:cd06174 223 STLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKP---------LLLIGLLLMALGLALLLLAPSL 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 364 AELVQLSIIVSMAAFSAYVPGYNTSIVTVAPQFTAFISSYAQLYAQIASTLAPIVIGRITSHGTIYEWkcAFYSLAGVLA 443
Cdd:cd06174 294 LLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTG--AFLVLAVLLL 371
|
....*.
gi 25141316 444 VTGLIF 449
Cdd:cd06174 372 LAAILL 377
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
26-415 |
1.53e-22 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 98.89 E-value: 1.53e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 26 RFQTALLISAACVVFGLMRTCFGMAMVDIVRsgngtfhpdlHMEWSGDEQANIHTSFYIGAFIAVFPSEFLAKKLGPKNL 105
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAA----------DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 106 LSFALLLNIFGSLLTPFSAiylrSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFL 185
Cdd:COG2814 78 LLLGLLLFALGSLLCALAP----SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 186 TAKLCQLHffeGWPLVFIVYGLIGAVFLVIWHVRLadkpRESKyitateltyikggKQRRNRAETIVRATPYMKIILngc 265
Cdd:COG2814 154 GGLLADLF---GWRWVFLVNAVLALLALLLLLRLL----PESR-------------PAARARLRGSLRELLRRPRLL--- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 266 vcAICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKQRKVnatavtkvsnaIA 345
Cdd:COG2814 211 --LLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRL-----------LL 277
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 25141316 346 SFASAIFIVIAAYGPFDSAELVQLSIIVSMAAFSAYVPGYNTSIVTVAP-QFTAFISSYAQLYAQIASTLA 415
Cdd:COG2814 278 IGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPpEARGRASGLYNSAFFLGGPLA 348
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
42-448 |
4.59e-22 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 98.41 E-value: 4.59e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 42 LMRTCFGMAMVDIVRSGNGTFHPDL--HMEWSGDEQANIHTSFYIGAFIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLL 119
Cdd:COG2223 7 LLLATLAFFLAFGVWYLWSVLAPPLaeEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 120 TPFSAiylrSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLcqLHFFeGWP 199
Cdd:COG2223 87 LALAV----SYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLL--IAAF-GWR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 200 LVFIVYGLIGAVFLVIWHVRLADKPRESKYITATELtyikggkqrrnraetivraTPYMKIILNGCVCAICACSFAQSFV 279
Cdd:COG2223 160 NAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASL-------------------RDQLEALRDPRFWLLSLLYFGTFGS 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 280 LVALVTYLPKYNQIAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKQRKVnatavtkvsnAIASFASAIFIVIAAYG 359
Cdd:COG2223 221 FIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRV----------LLIVFALMALGLLLLAL 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 360 PFDSAELVQLSIIVSMAAFSAYVPGYNTSIVTVAP-QFTAFISSYAQLYAQIASTLAPIVIGRITSHGTIYEWkcAFYSL 438
Cdd:COG2223 291 ALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPtKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTA--AFLVF 368
|
410
....*....|
gi 25141316 439 AGVLAVTGLI 448
Cdd:COG2223 369 AVLALVALVL 378
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
80-449 |
5.48e-19 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 88.83 E-value: 5.48e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 80 TSFYIGAFIAVFPSEFLAKKLGPKNLLsfalllnIFGSLLTPFSAIYLR---SYFPVAAIRLIMGFGYGFVIPAGSVLIS 156
Cdd:cd17475 38 SALNLGVAVSMLPAGWLLDRFGERRVL-------AVGLLLMGAAALLMAlvgSYPVLLVLLFLVGAGYGSVQPGGGRAIM 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 157 SWFPLSEKSTAMAIFTTGNQIGIAV-SMFLTAklCQLHFfeGWPLVFIVYGLI---GAVFLVIWHVrladKPRESKYITA 232
Cdd:cd17475 111 RWFPPRERGLAMGIRQTGVPLGGALaAALLPP--LALHY--GWRAAFVVAGLVsilAAVLFWLFYR----EPPAASAATE 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 233 TELTYIKGGKQ-RRNRAetivratpymkiilngcVCAICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLPFF 311
Cdd:cd17475 183 SASTLLRSLKEvLRNRD-----------------VWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 312 IQMITKLLFAIIADKV--KQRKVnataVTKVSNAIASFASAIFIVIAAYGPFdsAELVQLSIIVSMAAFSAYVPGYnTSI 389
Cdd:cd17475 246 GGALGRIGLGRVSDRVfgGRRRP----VLVITAAIAAAALLVLSLLSPGTPL--WLLVLLLILLGLFAIGWNGLYL-TLV 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 25141316 390 VTVAPQ-FTAFISSYAQLYAQIASTLAPIVIGRITSHGTIYEWkcAFYSLAGVLAVTGLIF 449
Cdd:cd17475 319 AESAGPeQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAP--AWLALALLLVLAALLL 377
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
80-449 |
7.69e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 82.24 E-value: 7.69e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 80 TSFYIGAFIAVFPSEFLAKKLGPKNLLsfalLLNIFGSLLTPFSAIYLRSYFPVAAIRLIMGFGYGFVIPAGSVLISSWF 159
Cdd:cd17325 38 AAYALAQLLFSPPAGRLSDRFGRKRLL----LLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 160 PLSEKSTAMAIFTTGNQIGIAVSMFLTAklcQLHFFEGWPLVFIVYGLIgAVFLVIWHVRLADKPRESKyitateltyik 239
Cdd:cd17325 114 PPEERGRAMGIFSSAIGLGFLIGPLLGG---LLADALGYRAPFLVCAAL-ALLALVLALLLLPEPRPPP----------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 240 ggkqRRNRAETIVRATPYMKIILNGCVCAICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLPFFIQMITKLL 319
Cdd:cd17325 179 ----NKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPP 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 320 FAIIADKVKQRKVnatavtkvsnAIASFAsAIFIVIAAYGPFDSAELVQLSIIVSMAAFSAYVPGYNTSIVTVAPQFT-A 398
Cdd:cd17325 255 AGKLSDRIGRKPL----------ILIGLL-LSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGrG 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 25141316 399 FISSYAQLYAQIASTLAPIVIGRITSHgtiYEWKCAFYSLAGVLAVTGLIF 449
Cdd:cd17325 324 TAMGLFNTAFSLGMVLGPLLGGFLYDA---FGFATPFLAAAALLLLAAVLF 371
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
28-454 |
2.47e-16 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 81.05 E-value: 2.47e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 28 QTALLISAACVVFGLmrtcFGMAMvdivrSGNGTFHPDL--HMEWSGDEQANIHTSFYIGAFIAVFPSEFLAKKLGPKNL 105
Cdd:COG0738 5 NYRRALIAIYLLFFL----WGFAT-----ALWGPLIPALkdAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRG 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 106 LSFALLLNIFGSLLTPFSaiylRSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSeKSTAMAIFTTGNQIGIAVSMFL 185
Cdd:COG0738 76 LLLGLLLMALGLLLFALA----PSYPLLLLALFLLGLGLGLLDVAANPYVAALGPET-AASRLNLLHAFFSLGALLGPLL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 186 TAKLCQLHFFEGWPLVFIVYGLIGAV-FLVIWHVRLADKPRESkyitateltyikggkqrrnrAETIVRATPYMKIILNG 264
Cdd:COG0738 151 GGLLILLGLSLSWHLPYLILAVLLLLlALLFLRSKLPEIEEEE--------------------EEAAGSAASLKSLLKNP 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 265 CVCAICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKQRKVnatavtkvsnaI 344
Cdd:COG0738 211 RLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRL-----------L 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 345 ASFASAIFIVIAAYGPFDSAELVQLSIIVSMAAFSAYVPGYNTSIVTVAPQFTAFISSYAQLYAQIASTLAPIVIGRITS 424
Cdd:COG0738 280 RLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLAD 359
|
410 420 430
....*....|....*....|....*....|
gi 25141316 425 HGTIYewkcAFYSLAGVLAVTGLIFQIFGH 454
Cdd:COG0738 360 AFGLR----AAFLVPLVCYLLILLLALALK 385
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
65-420 |
2.28e-15 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 78.06 E-value: 2.28e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 65 DLHMEwsGDEQANIHTSFYIGAFIAVFPSEFLAKKLGPKNLLSFALLLnifGSLLTPFSAiYLRSYFPVAAIRLIMGFGY 144
Cdd:cd17327 35 DLKLV--GNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVL---WGLLTLLTA-AVKNFGGLIALRFFLGLFE 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 145 GFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTA---KLCQLHFFEGWPLVFIVYGLIGAVFLVIWHVRLA 221
Cdd:cd17327 109 SGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYgvfKILGVGGLAGWRWLFIIEGLITIIIGLVIFFWLP 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 222 DKPRESKYITATELTYIKGGKQRRNRA--ETIVRATPYMKIILNGCVCAICACSFAQSFVLVALVTYLPkynqiAFKMNL 299
Cdd:cd17327 189 DNPSKAWFLTEEEKELAVERLRANQTGkgDQKFKWKQIKEAFKDPRTWLLFLFFFCSQITNNGISNFLP-----LILKSL 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 300 THNGIWSSL----PFFIQMITKLLFAIIADKVKQRKVNATAVTkvsnaiaSFASAIFIVIAAygpfdsaelVQLSIIVSM 375
Cdd:cd17327 264 GFYSLQTNLlsvpIGALGAVSLLIAALLSDRFKKRGLFAIFAC-------VLALVGSIILLA---------APNPPGAYF 327
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 25141316 376 AAFSAYVPGYNTSIVTVapqftAFISSYAQLYAQIASTLAPIVIG 420
Cdd:cd17327 328 AAYILGGGSYAGFPILL-----SWISSNCAGYTKRATVLAIMLIF 367
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
26-453 |
8.13e-14 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 73.37 E-value: 8.13e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 26 RFQTALLISAACVVFGL-MRTCFGM--AMVDIVRSgngtfhpDLHMEWSgdeQANIHTSFYIGAFIAV-FPSEFLAKKLG 101
Cdd:COG2807 12 RRAGRWLLLLAIVLVALnLRPAITSvgPLLPEIRA-------DLGLSAT---QAGLLTTLPLLAFGLFaPLAPRLARRFG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 102 PKNLLSFALLLNIFGSLLTPFSAiylrSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPlSEKSTAMAIFTTGNQIGIAV 181
Cdd:COG2807 82 LERTLLLALLLLAAGLLLRSLAP----SVALLLAGTALIGAGIAVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAAL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 182 SMFLTAKLCQLHffeGWPLVFIVYGLIGAVFLVIWHVRLADKPReskyitateltyikggkqRRNRAETIVRATPYMKII 261
Cdd:COG2807 157 AAGLTVPLAAAL---GWRGALAVWALLALLALLLWLPLLRRRPA------------------AAAAAPAAASLRSLWRSP 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 262 LngcVCAICACSFAQSFVLVALVTYLPKYNQiAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKQRKVNATAVTkvs 341
Cdd:COG2807 216 L---AWLLTLFFGLQSLLYYAVVAWLPPILR-DAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLG--- 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 342 nAIASFASAIFIVIAAYGPFDSAELVQL----SIIVSMAAFSAYVPGyntsivtvaPQFTAFISSYAQLYAQIASTLAPI 417
Cdd:COG2807 289 -LLGLAGLLGLLLAPGSLPWLWAVLLGLgqggLFPLALTLIGLRART---------PAEAAALSGMAQSVGYLLAALGPL 358
|
410 420 430
....*....|....*....|....*....|....*.
gi 25141316 418 VIGRItsHGTIYEWKCAFYSLAGVLAVTGLIFQIFG 453
Cdd:COG2807 359 LVGAL--HDATGSWTAALLLLAALAVLMLVAGLLAG 392
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
87-453 |
7.91e-13 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 69.91 E-value: 7.91e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 87 FIAVF--PSEFLAKKLGPKNLLSFALLL-NIFGSlltpfSAIYLRSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSE 163
Cdd:cd17473 47 FIALFapLAGWLADRFGRKRLLIAGLLLyGIGGV-----AGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEE 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 164 KSTAMAIFTTGNQIGIAVSMFLTAKLCQLhffeGWPLVFIVYGLIGAVFLVIWHvrladkpreskyitateltYIKGGKQ 243
Cdd:cd17473 122 RAKMLGLQSAAMSLGGVVFLLLGGALAEI----GWRAPFLVYLLALPVLILVLL-------------------FLPEPAR 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 244 RRNRAETIVRATPymKIILNGCVCAICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLPFFIQMITKLLFAII 323
Cdd:cd17473 179 KSKSAASPGAATA--AALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 324 ADKVKQRKVNATAVtkvsnaiASFASAIFIVIAAYGPFdsaeLVQLSIIVSMAAFSAYVPGYNTSIVTVAP-QFTAFISS 402
Cdd:cd17473 257 KRRLGKRRLLAIGF-------ALMALGFLLLALASGLW----VVLLGAILAGLGFGLLLPTLNSWAMSLVPpELRGRAMG 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 25141316 403 YAQLYAQIASTLAPIVIGRITSHGTIYEwkCAFYSLAGVLAVTGLIFQIFG 453
Cdd:cd17473 326 IVTSAFFLGQFLSPLVLGPLVNLTGGLS--GAFLILGVLALVLAIVLLLLR 374
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
71-435 |
1.35e-12 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 69.33 E-value: 1.35e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 71 SGDEQANIHTSFYIGAFIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLLTPFSAiylrSYFPVAAIRLIMGFGYGFVIPA 150
Cdd:TIGR00881 28 SKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST----SLWVMAALWALNGIFQGMGWPP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 151 GSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHFfeGWPLVFIVYGLIGAVFLVIWHVRLADKPReSKYI 230
Cdd:TIGR00881 104 CGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELY--SWHWVFIVPGIIAIIVSLICFLLLRDSPQ-SCGL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 231 TATELTYIKGGKQRRNRAETIVRATPYM--KIILNGCVCAICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSL 308
Cdd:TIGR00881 181 PPAEEMPNEEPDGDAEKKEEELTKKQIFlqYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTL 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 309 PFFIQMITKLLFAIIADKVKQRKVNATAVtkvsnaiaSFASAIFIVIAAYGPFDSAELVQLSIIVSMAAFSAYVPGYNTS 388
Cdd:TIGR00881 261 YELGGLVGTLLAGWLSDKLFNGRRGPLAV--------FFMALIIVSLLVYWLNPAANPLMDLICLFALGFLVYGPQMLIG 332
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 25141316 389 IVTV--APQFTAFISS-YAQLYAQIASTLAPIVIGRITSHgtiYEWKCAF 435
Cdd:TIGR00881 333 VIASelAPKKAAGTAAgFVGFFAYLGGILAGLPLGYLADG---FGWAGAF 379
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
64-358 |
4.59e-12 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 67.71 E-value: 4.59e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 64 PDLHMewSGDEQANIHTSFYIGAFIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLLTPFSAiylRSYFPVAAIRLIMGF- 142
Cdd:TIGR00886 30 DDLGL--STAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAV---QSYSVLLLIRLFIGIa 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 143 GYGFVIpaGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHFFE---------GWPLVFIVYGLIGAVFL 213
Cdd:TIGR00886 105 GGSFAS--CMPWISFFFPKKIQGTALGLAAGWGNMGGGVAQFVMPPIIGSLIFGggqpahlawGWAFVIVPAGILLLPAL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 214 VIWHVRLADKPRESKYITATELTYIKGGKQRRnraeTIVRATPYMkiilngcvcaicaCSFAqsfVLVALVTYLPKYNQI 293
Cdd:TIGR00886 183 LIFFVGADTPPGKPATGKLSFKEALKVFGNRH----TWILALLYS-------------VTFG---SFLGVSSIFAMLFKD 242
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 25141316 294 AFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKQRKVNATAVTKVSNAIA----------SFASAIFIVIAAY 358
Cdd:TIGR00886 243 QFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGGARKLLMNFLGVAMGAFlvvlglvsdgSLAAFIVLFVALF 317
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
80-452 |
1.01e-11 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 66.44 E-value: 1.01e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 80 TSFYIGAFIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLLTPFSAiylrSYFPVAAIRLIMGFGYGFVIPAGSVLISSWF 159
Cdd:cd17474 41 TAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSD----SFALLLAGRALQGIGAAGLGPLALTLIGDLF 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 160 PLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLhffeGWPLVFIVYGLIGAVFLVIWHVRLADKPRESKYITATELTyiK 239
Cdd:cd17474 117 EGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI----SWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLR--D 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 240 GGKQRRNRAETIVRATpymkiilngcvcaicacSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLPFFIQMITkll 319
Cdd:cd17474 191 LKKALRGRGLLTFLVS-----------------AFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALG--- 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 320 fAIIADKVKQRKVNATAVTKVSNAIASFASAIFiviaayGPFDSAELVQLSIIVSMAAFSAYVPGYNTSIVTVAP-QFTA 398
Cdd:cd17474 251 -SLFVGRLLKKRFGARRILVIGLLLYALSLLLL------GFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPeEERG 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 25141316 399 FISSYAQLYAQIASTLAPIVIGRITSHgtiYEWKCAFYSLAGVLAVTGLIFQIF 452
Cdd:cd17474 324 TASSLYNFVRFLGQAVGPLLFGLLLEI---FGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
95-449 |
1.43e-10 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 62.96 E-value: 1.43e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 95 FLAKKLGPKNLLSFALLLNIFGSLLTPFSAiylrSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPlSEKSTAMAIFTTG 174
Cdd:cd17478 53 YLADRKPRRYLLPLGPLLTGLGLSLLGFAP----NYWLLLLLVALAGIGSAAFHPEGARLASQAAG-GRRGLAMSIFSVG 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 175 NQIGIAVSMFLTAKLCQLHFFEGWPLVFIvygLIGAVFLVIWHVRLADKPRESKyitateltyikggKQRRNRAETIVRA 254
Cdd:cd17478 128 GNLGFALGPLIAAALVALFGGLGLLILLI---IPGLAVALLLLRLRPLKKPEAK-------------KAAAKSSARSTLK 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 255 TPYMKIILngcvcaICACSFAQSFVLVALVTYLPKYnQIAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKQRKVna 334
Cdd:cd17478 192 GVWRALLL------LLIIVFLRSWVLSSLTTFLPFY-LVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRV-- 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 335 tavtkvsnaiasFASAIFIVIAAYGPFDSAELVQLSIIVSMAAFSAYVPGYnTSIVTV---APQFTAFISSYAQLYAQIA 411
Cdd:cd17478 263 ------------IIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFP-VTVVLAqelLPGNVGLASGLMMGLSFGL 329
|
330 340 350
....*....|....*....|....*....|....*...
gi 25141316 412 STLAPIVIGRITSHGTIYEwkcAFYSLAgVLAVTGLIF 449
Cdd:cd17478 330 GGIGAPVLGALADAFGLES---VLLILA-LLPLLGALL 363
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
84-420 |
6.10e-10 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 61.22 E-value: 6.10e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 84 IGAFIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLLTPFSAiylrSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSE 163
Cdd:TIGR00895 63 IGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALAT----NVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRF 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 164 KSTAMAIFTTGNQIGIAVSMFLTAKLCQLHffeGWPLVFIVYGLIGAVFLVIWH-----------VRLADKPRESKYITA 232
Cdd:TIGR00895 139 RGTAVGLMFCGYPIGAAVGGFLAGWLIPVF---GWRSLFYVGGIAPLLLLLLLMrflpesidflvSKRPETVRRIVNAIA 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 233 TELTYIKGGKQRRNRAETIVrATPYMKIILNGCVCAIC----ACSFAQSFVLVALVTYLPKYnQIAFKMNLTHNGIWSSL 308
Cdd:TIGR00895 216 PQMQAEAQSALPEQKSTQGT-KRSVFKALFQGKTARITvllwLLYFMLLVGVYFLTNWLPKL-MVELGFSLSLAATGGAL 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 309 PFFIQMITKLLFAIIADKVKQRKVnatavtkvsnAIASFASAIFIVIAAYGPFDSAELVQLSIIVSMAAFSAYVPGYNTS 388
Cdd:TIGR00895 294 FNFGGVIGSIIFGWLADRLGPRVT----------ALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALM 363
|
330 340 350
....*....|....*....|....*....|..
gi 25141316 389 IVTVAPQFTAFISSYAQLYAQIASTLAPIVIG 420
Cdd:TIGR00895 364 ALFYPTAIRATGVGWAIGIGRLGAIIGPILAG 395
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
80-449 |
6.24e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 57.99 E-value: 6.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 80 TSFYIGAFIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLLTPFSAiylrSYFPVAAIRLIMGFGYGFVIPAGSVLISSWF 159
Cdd:cd17489 38 GLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT----SVALLLVLRLIHGIGWGAFTTAAATLVADII 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 160 PLSEKSTAMAIF----TTGNQIGIAVSMFLTAKLcqlhffeGWPLVFIVYGLIGAV-FLVIWHVrladKPRESKYITATE 234
Cdd:cd17489 114 PPSRRGEGIGYYglatTLAMALGPALGLFLYQHL-------GFAVLFIVAAVLALLaLLLVFLV----KDPPPVAAEEAE 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 235 LTyikggkqrrnraetivraTPYMKIILNGCVCAICACSFAQSFVLVALVTYLPKYnqiAFKMNLTHNGIWSSLPFFIQM 314
Cdd:cd17489 183 AG------------------TRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLY---AAERGISNAGLFFTVYAIALL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 315 ITKLLFAIIADKVKQRKVnatavtkvsnaIASFASAIFIVIAAYGPFDSAELVQLSIIVSMAAFSAYVPGYNTSIVTVAP 394
Cdd:cd17489 242 LSRPFSGKLSDRKGPKTV-----------IIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVP 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 25141316 395 --QFTAFISSYAQLYAqIASTLAPIVIGRITSHgtiYEWKCAFYSLAGVLAVTGLIF 449
Cdd:cd17489 311 phRRGAANGTFFIFFD-LGIGLGGLLLGLVAEL---FGYRAMFLLAAVVVLLALVLY 363
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
67-449 |
9.63e-09 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 57.31 E-value: 9.63e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 67 HMEWSGDEQANIHTSFYIGAFIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLLTPFSaiylRSYFPVAAIRLIMGFGYGF 146
Cdd:cd17371 28 EFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFA----QNYWQLLILRALAGLGFGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 147 VIPAGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHFFE-GWPLVFIVyGLIGAvfLVIWHVRLADKpr 225
Cdd:cd17371 104 EWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEiAWRVLFLL-GALPA--LLVLFIRRFVK-- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 226 ESKYITATELTYIKGGKQRRNRAetiVRATPYMKIILNGCVCAICAcsfaqSFVLVALVTYLPKYNQIAFKMNLTHNGIW 305
Cdd:cd17371 179 EPPQWQAARAARRHFADRPSLRE---LFSPPLLRTTLLASLLATGA-----LGGYYGITTWLPSYLTGERGLSFEGSAGY 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 306 SSLPFFIQMITKLLFAIIADKVKQRKvnatavtkvSNAIASFASAIFIVIAAYGPFDSAELVQLSIIVSM------AAFS 379
Cdd:cd17371 251 LVVTILGGFLGYLAGGFLADRIGRRN---------NFALFALGSAISILLYFFLPLSPTLILILGFPLGFfasgpfSGMG 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 25141316 380 AYVP-GYNTSIVTVApQFTAFIssyaqlYAQIASTLAPIVIGRITSHGTIyEWKCAFYSLAGVLAVTGLIF 449
Cdd:cd17371 322 AYLTeLFPTAVRATA-QGFCYN------VGRIIGALFPFLVGFLATSGSL-GTAIAVFAAVYYIAGLVLAL 384
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
26-215 |
1.29e-08 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 56.36 E-value: 1.29e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 26 RFQTALLISAACVVFGLMRTCFGMAMVDIVRsgngtfhpDLHMewSGDEQANIHTSFYIGAFIAVFPSEFLAKKLGPKNL 105
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAA--------DLGA--SSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 106 LSFALLLNIFGSLLTPFSAiylrSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFL 185
Cdd:COG0477 82 LLIGLLLFGLASLLCGLAP----SPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLL 157
|
170 180 190
....*....|....*....|....*....|
gi 25141316 186 TAKLcqLHFFeGWPLVFIVYGLIGAVFLVI 215
Cdd:COG0477 158 GGLL--VAAL-GWRWIFLINAPLGLLALVL 184
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
84-214 |
4.76e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 55.26 E-value: 4.76e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 84 IGAFIAVFPSefLAKKLGPKNLLSFALLLNIFGSLLTPFSAIYLrsyFPVAAiRLIMGFGYGFVIPAGSVLISSWFPLSE 163
Cdd:cd17321 44 FAALLLLAGR--LGDRFGRKRVFLIGLALFGLASLLCALAPSLA---FLIAA-RALQGIGAAAIMPASLALIAATFPGER 117
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 25141316 164 KSTAMAIFTTGNQIGIAVSMFLTAKLCQLHffeGWPLVFIVYGLIGAVFLV 214
Cdd:cd17321 118 RGRALGLWGAVVGIGAALGPLLGGLLLELF---GWRWIFLINVPIGLVALL 165
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
80-426 |
9.31e-08 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 54.09 E-value: 9.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 80 TSFYIGAFIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLLTPFSaiylRSYFPVAAIRLIMGFGYGFVIPAGSVLISSWF 159
Cdd:cd17324 41 SAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALA----PSFALLLLARALAGLAHGGFWAIAAAYAADLV 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 160 PLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQlhfFEGWPLVFIVYGLIGAVFLVIWHVRLADKPRESKYITATELTYIK 239
Cdd:cd17324 117 PPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQ---LLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLL 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 240 GGKQRRNRAetivratpymkiilngcVCAICACSFaqsFVLVALVTYLPkynqiAFKMNLTHN-GIWSSLPFFIQMITKL 318
Cdd:cd17324 194 LLRNPRLRL-----------------AYLITFLLF---GGFFALYTYLA-----PFLTDVPGFsSSAIIGLLLLFGVAGV 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 319 LFAIIADKVKQRKVNATAVtkvsnAIASFASAIFIVIAAYGPfdSAELVQLSIIVSMAAFSAYVPGYNTSIVTVAPQFTA 398
Cdd:cd17324 249 VGSPLAGRLADRGGRRALL-----IALLLLAAALLLLTLLGP--SPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARG 321
|
330 340
....*....|....*....|....*...
gi 25141316 399 FISSYAQLYAQIASTLAPIVIGRITSHG 426
Cdd:cd17324 322 LASSLYLAAYNLGGALGAALGGLVLDHG 349
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
81-216 |
2.18e-07 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 53.42 E-value: 2.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 81 SFYIGAFIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLLTPFSAIyLRSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFP 160
Cdd:cd17357 57 IFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSKS-AKSPELLIFGRFLVGIACGLSTGFVPMYLQEISP 135
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 161 LSEKSTamaiFTTGNQIGIAVsMFLTAKLCQLHFFEG----WPLVFIVYGLIGAVFLVIW 216
Cdd:cd17357 136 SELRGA----LGSLTQIGVTL-GILLGQVFGLPSVLGtetlWPYLLFFPGIPALLQLAAL 190
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
31-221 |
2.87e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 52.56 E-value: 2.87e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 31 LLISAACVVFGLMRT---CFGMAMVDIVRSGNGTFHPDLHME---WSGDEQANIHTSFYIGAFIAVFPSEFLAKKLGPKN 104
Cdd:COG2271 168 LILGLPGLLLALLRFwllALAYFLVYFALYGFLTWLPTYLVEvrgLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRR 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 105 LLSFALLLniFGSLLTPFSAIYLRSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMF 184
Cdd:COG2271 248 KLVLAIGL--LLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPL 325
|
170 180 190
....*....|....*....|....*....|....*..
gi 25141316 185 LTAKLCQLHFFEGWPLVFIVYGLIGAVFLVIWHVRLA 221
Cdd:COG2271 326 LVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
84-215 |
3.50e-07 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 52.20 E-value: 3.50e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 84 IGAFIAvfpsEFLAKKLGPKNLLSFALLLNIFGSLLTPFSaiylRSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSE 163
Cdd:cd17365 49 IGALLA----GPLADRFGRKRVLLVSVALFGLFTLLTAFA----QSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARR 120
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 25141316 164 KSTAMAIFTTGNQIGIAVSMFLTAKLCQLHffeGWPLVFIVYGLIGAVFLVI 215
Cdd:cd17365 121 RSLAVTLMFCGYPLGAALGGFLAAALIPAF---GWRSVFLLGGVPPLILLPL 169
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
80-220 |
3.78e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 52.19 E-value: 3.78e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 80 TSFYIGAFIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLLTPFSaiylRSYFPVAAIRLIMGFGYGFVIPAGSVLISSWF 159
Cdd:cd17325 242 GAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLA----TSFWLLLLLLALLGLGLGLVFPATLALLADIV 317
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 25141316 160 PLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHffeGWPLVFIVYGLIGAVFLVIWHVRL 220
Cdd:cd17325 318 PPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAF---GFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
70-215 |
5.23e-07 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 51.92 E-value: 5.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 70 WSGDEQANIHTSFYIGAFIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLLTPFsaiyLRSYFPVAAIRLIMGFGYGFVIP 149
Cdd:cd06180 31 LSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMAL----TSGFAALLALRFLAGAASAFVFV 106
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 25141316 150 AGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHFfeGWPLVFIVYGLIGAVFLVI 215
Cdd:cd06180 107 FGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGGL--SWRAGWLALALLSAVLLLL 170
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
83-448 |
7.21e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 51.45 E-value: 7.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 83 YIGAFIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLLTPFSAiylrSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLS 162
Cdd:cd17316 46 FLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLP----TPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSK 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 163 EKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHFFE-GWPLVFIVyGLIGAVFLVIWHVRLadkpreskyitateltyikgg 241
Cdd:cd17316 122 RRGFALGLLQSGWALGALLAALVASLLIPLLSGDwGWRILFLI-GALPALLALLLRRRT--------------------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 242 kqrrnraetivratpymkiilngcVCAICAcSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLPFFIQMITKLLFA 321
Cdd:cd17316 180 ------------------------LLLILL-WFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 322 IIADKVKQRKVNATAvtkvsnAIASFASAIFIVIAAYGPFDSAELVQLSIIVSMAAFSAYVPGYNTSIVTVAPQFTAFIS 401
Cdd:cd17316 235 LLSDRIGRKKTLVIG------LILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGL 308
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 25141316 402 SYAQLYAqIASTLAPIVIGRITSHGTIYewkcAFYSLAGVLAVTGLI 448
Cdd:cd17316 309 SYNLGRL-GGGGAPPLIALLLASTGGTG----VPALILALLAIVALI 350
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
80-449 |
1.04e-06 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 51.08 E-value: 1.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 80 TSFYIGAFIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLLTPFSaiylRSYFPVAAIRLIMGFGYGFVIPAGSVLISSWF 159
Cdd:cd17328 41 TVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFA----PNFWQLLLFRALVGIGEASYSPIAPTIIADLF 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 160 PLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHFfeGWPLVFIVYGLIGAVFLVIWHVRLADKPRESkyitateltyIK 239
Cdd:cd17328 117 PKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATG--GWRWAFRVTGVLGVLLAILLLLFVREPPRGA----------AE 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 240 GGKQRRNRAETIVRAtpyMKIIL-NGCVCAICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLPFFIQMITK- 317
Cdd:cd17328 185 GGVMAKSTATSFLAD---LKALAkNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVGLIFGAITCIAGv 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 318 ---LLFAIIADKVKQRKVNATAVTkvsNAIASFASAIFIVIAAYGPFDSAELVQLSIIVSMAAFSAYVpGYNTSIV--TV 392
Cdd:cd17328 262 lgvLLGGILADRLRRKTPRADPLV---CAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEFLLSLNW-APVFAILlyVV 337
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 25141316 393 APQFTAFISSYAQLYAQ-IASTLAPIVIGRITSHGTIYE---------WKCAFYSLAGVLAVTGLIF 449
Cdd:cd17328 338 IPTRRSTASAIQILLSHlLGDAGSPYLIGLISDLLRQNKdsplaeaasLQYALLLCSFVLVLGGFFF 404
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
76-429 |
1.05e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 50.78 E-value: 1.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 76 ANIHTSFYIGAFIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLLTPFSAiylrSYFPVAAIRLIMGFGYGFVIPAGSVLI 155
Cdd:cd17333 34 SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATP----SIYLFVVLMFLAGLGAGILDTGANTFV 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 156 SSWFPlSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHFfeGWPLVFIVYGLIGAVFLVIWhVRLADKPRESKYITATEL 235
Cdd:cd17333 110 GALFE-ESSATRLNVLHGFFGLGALIGPLIATSLLTSEL--SWSWAYLIIGLIYLLLAILI-LLTLFPELPSARNPQQSV 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 236 TYIKGGKQRRNRaetivratpymkiilNGCVCAICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLPFFIQMI 315
Cdd:cd17333 186 GAFSASASRLLR---------------NPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITI 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 316 TKLLFAIIADKVKQRKVNATA-----VTKVSNAIASFASAIFIVIAAYGPFDSAeLVQLSIIVSMAAFSAYVPGYNTSIV 390
Cdd:cd17333 251 GRLLGGPISRRIKPHTLLVLSgsgalLGLLILLLAPTLVVGLVATALLGLFMAA-LFPTILSLGISNLPYAKGKGTSVLL 329
|
330 340 350
....*....|....*....|....*....|....*....
gi 25141316 391 TVapqftafissyaqlyAQIASTLAPIVIGRITSHGTIY 429
Cdd:cd17333 330 AA---------------GSIGGAIIPFIMGFIAEAVGIQ 353
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
95-448 |
1.72e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 50.30 E-value: 1.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 95 FLAKKLGPKNLLSFALLLNIFGSLLTPFsaiyLRSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTG 174
Cdd:cd17329 57 RLADRFGRKPVMLAGLLLRALGFALLGF----AHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWA 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 175 NQIGIAVSMFLTAKLCQLHFFegwpLVFIVyGLIGAVFLVIWHVRLadKPRESKYITATELTYIKGGKQrrnraeTIVRA 254
Cdd:cd17329 133 INLGVAIGPLLGGLLLLYSFR----LLFLA-AAVLFLLAALVLLFL--LPETRPKRRAAEKTEILRGYK------IVLRD 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 255 TPYMkiilngcvcAICACSFAQSFVLVALVTYLPKYNQiafkmNLTHNGIWS-SLPFFIQMITKLLFAIIADKVKQRKvn 333
Cdd:cd17329 200 RAFL---------LFLLASFLISLIYFQLESTLPVYVV-----EILGLGESLlGLLLALNALLIVLLQFPVARLVERF-- 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 334 atavtkvsNAIASFASAIFIVIAAYGPFDSAELVqLSIIVSMAAFSA----YVPGYNTSIVTVAPQFT--AFISSYAQLY 407
Cdd:cd17329 264 --------RLRKILMIGILLFAIGFAVLAFANTL-AVLILAMIVLTLgemlVFPAVQTLVAALAPPDKrgSYMGFYALAW 334
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 25141316 408 AqIASTLAPIVIGRITSHGtiyewkcAFYSLAGVLAVTGLI 448
Cdd:cd17329 335 G-LGRAIGPLVGGLLLDLL-------GPGLPWLILAALGLI 367
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
82-182 |
1.91e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 50.25 E-value: 1.91e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 82 FYIGAFIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLLTPFsAIYLRSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPL 161
Cdd:cd17321 213 LALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLAL-LGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPK 291
|
90 100
....*....|....*....|.
gi 25141316 162 SEKSTAMAIFTTGNQIGIAVS 182
Cdd:cd17321 292 EKAGAASGILNTARQLGGALG 312
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
76-218 |
2.04e-06 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 49.89 E-value: 2.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 76 ANIHTSFYIGAFIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLLTPFSaiylRSYFPVAAIRLIMGFGYGFVIPAGSVLI 155
Cdd:cd17317 28 ALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFS----PSYELFLVLRFLVGVTSAGIFTVGFVLG 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 25141316 156 SSWfpLSEKSTAMAifTTGNQIGIAVSMFLTAKLC-------QLHFFEGWP-LVFIVYGLIGAVFLVIWHV 218
Cdd:cd17317 104 MEI--VGPKYRSFV--GILFGLFWALGYMLLALLAylirdwrWLQLAISLPgLLFLLLLWWLPRRTIIVGL 170
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
80-220 |
2.66e-06 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 49.88 E-value: 2.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 80 TSFYIGAFIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLLtpfsaIYLRSYFPVAAI-RLIMGFGYGFVIPAGSVLISSW 158
Cdd:cd17503 38 TSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLL-----CGLAPNLASLIIfRILQGFGGGVLIPLAQTILLRI 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 25141316 159 FPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQlHFfeGWPLVFIV---YGLIGAVFLVIWHVRL 220
Cdd:cd17503 113 YPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTD-NL--SWRWIFYInlpIGILALLLAPLLDLRL 174
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
78-225 |
2.72e-06 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 49.58 E-value: 2.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 78 IHTSFYIGAFIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLLTPFSAiylrSYFPVAAIRLIMGFGYGFVIPAGSVLISS 157
Cdd:cd17312 43 IGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFST----SLWFFAVLWGLNGLFQSMGWPPCVKLLGN 118
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 25141316 158 WFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHffeGWPLVFIVYGLIGAVFLVIWHVRLADKPR 225
Cdd:cd17312 119 WFSKKERGTVYGIWSTSHNFGGILAPILAASLASYY---GWRAAFLVPGIVGLVVAIILFFFLRDSPP 183
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
84-216 |
7.42e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 48.34 E-value: 7.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 84 IGAFIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLLTPFSAiylrSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSE 163
Cdd:cd17473 244 LAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALAS----GLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPEL 319
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 25141316 164 KSTAMAIFTTGNQIGIAVSMFLTAKLCQLHFfeGWPLVFIVYGLIGAVFLVIW 216
Cdd:cd17473 320 RGRAMGIVTSAFFLGQFLSPLVLGPLVNLTG--GLSGAFLILGVLALVLAIVL 370
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
85-378 |
8.82e-06 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 48.02 E-value: 8.82e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 85 GAFIAVfPSEFLAKKLGPKNLLSFALLLNIFGSLltpFSAIYLRSYFPVAAIRLIMGFGYG-FVIpaGSVLISSWFPLSE 163
Cdd:cd17341 47 GALLRL-PYGFLCDRFGGRRVFIASLLLLLIPLL---ALALAVSSYWGLLVLGFLLGFAGAnFAS--GQPWASFWFPKEK 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 164 KSTA-MAIFTTGNqIGIAVSMFLTAKLCQLHFFE----GWPLVFIVYGLIGAVFLVIwHVRLADKPRESKYITATELTYI 238
Cdd:cd17341 121 IGGAaGGIAGAGN-MGVAVSQLLAPLIAGAIVFDggfvGWRNAFFVPGILLAIAAVL-VLLFGDDLPTGKASALEFLKVQ 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 239 KGGKQRRNraeTIVRATPYmkiilngcvcaicACSFAqsfVLVALVTYLPKYNQIAFKMNLTHNGIWSSLPFFIQMITKL 318
Cdd:cd17341 199 LAVLKNYR---TWILSLLY-------------GVTFG---SFVGFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARP 259
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 319 LFAIIADKVKQRKVnatavtkvsNAIASFASAIFIVIAAYGPFDSAELVQLSIIVSMAAF 378
Cdd:cd17341 260 AGGWLSDRFGGRRR---------LWWLFIVMTIGAALLSLSLPTSGTNLVLFLALFVALG 310
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
47-449 |
1.16e-05 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 47.62 E-value: 1.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 47 FGMAMVDIVRSGNGTFHPDLHME--WSGDEQANIHTSFYIGAFIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLLTPFSA 124
Cdd:cd17345 10 IGYAGYYLVRNNFSLAQPYLIEQygLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVP 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 125 IYLRSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHFFEGWPLVFIV 204
Cdd:cd17345 90 SATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGDGWWRGAFIF 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 205 YGLIGAVFLVIWHVRLADKPRE------SKYITATELTYIKGGKQRRNRAETIVratpyMKIILNGCVcaICACSFAQSF 278
Cdd:cd17345 170 PAIIAIIVAVIVLFLGKDTPESeglppiEEYKGDYPEEADGEEEEQELSAWEIF-----VKYVLKNKL--LWYIAIANVF 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 279 VLVA---LVTYLPKYNQIAFKMNLTHnGIWSSLPFFIQMI-TKLLFAIIADKvkqrkvnataVTKVSNAIASFASAIFIV 354
Cdd:cd17345 243 VYLVrygILDWAPTYLSEVKGFSKAQ-AMWAFSLFEWAAIpGTLLAGWLSDK----------LFKGRRAPTGIIFMILVI 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 355 IAAYGPFDSAELVQLSIIVSMAAFSAYVPGYNTSIVT--VAPQFTA-----FISSYAQLyaqIASTLAPIVIGRITSHgt 427
Cdd:cd17345 312 VALIVYWLAPNVLVDLIALIALGFLIYGPVMLIGLQAleLVPKKAAgtaagLTGLFGYL---GGSVLATALIGIIVDH-- 386
|
410 420
....*....|....*....|....
gi 25141316 428 iYEWKCAFYSL--AGVLAVTGLIF 449
Cdd:cd17345 387 -FGWNGGFIVLlaSCILAIIFLAL 409
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
80-219 |
1.71e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 47.22 E-value: 1.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 80 TSFYIGAFIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLLTPFSaiylRSYFPVAAIRLIMGFGYGFVIPAGSVLISSWF 159
Cdd:cd06173 251 AAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLS----PSLWLLLAALFLLGLAGGLFNVPLNTLLQLRV 326
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 160 PLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHffeGWPLVFIVYGLIGAVFLVIWHVR 219
Cdd:cd06173 327 PDELRGRVFSVYNALNSGAMPLGALLAGLLADAL---GLSAVFLLAGALLLLAALLLLLL 383
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
80-187 |
1.96e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.20 E-value: 1.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 80 TSFYIGAFIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLLTPFsaIYLRSYFPVAAIRLIMGFGYGFVIPAGSVLISSWF 159
Cdd:COG2211 271 ALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFF--LGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVV 348
|
90 100 110
....*....|....*....|....*....|....*
gi 25141316 160 PLSEKST-------AMAIFTTGNQIGIAVSMFLTA 187
Cdd:COG2211 349 DYDEWKTgrrreglYFGIFTFAIKLGQALAGALAG 383
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
84-215 |
2.77e-05 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 46.41 E-value: 2.77e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 84 IGAFIAVFPSEFLAKKLGPKNLLSFALLLNIFGSL-LTPFSAIYLRSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPlS 162
Cdd:cd17320 248 IALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALvLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFP-H 326
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 25141316 163 EKSTAMAIFTTGNQIGIAVSMFLTAklcQLHFFEGWP--LVFIVYGLIGAVFLVI 215
Cdd:cd17320 327 VAGTASALLGFLQFLIGALAGALVG---LLPNGTALPmgLLILVLGLLALLLLIL 378
|
|
| MFS_FLVCR_like |
cd17398 |
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ... |
90-185 |
3.26e-05 |
|
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340956 [Multi-domain] Cd Length: 406 Bit Score: 46.46 E-value: 3.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 90 VFPSEFLAKKLGPKNLLSFALLLNIFGSLLTPFSAIYLRSYFPVAAiRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMA 169
Cdd:cd17398 56 IFPATWLLEKYGLRVTVLLGSFLNCLGAWLKLFSSSPDLFWVAMAG-QTICALAQVFILGIPPRLAAVWFGPDEVSTATA 134
|
90
....*....|....*.
gi 25141316 170 IFTTGNQIGIAVSMFL 185
Cdd:cd17398 135 IGVFGNQLGVALGFVL 150
|
|
| MFS_NIMT_CynX_like |
cd17339 |
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ... |
86-455 |
3.41e-05 |
|
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340897 [Multi-domain] Cd Length: 374 Bit Score: 46.03 E-value: 3.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 86 AFIAVFPSeFLAKKLGPKNLLSFALLLNIFGslltpfsaIYLRSYFPVAAI---RLIMGFGYGFvipaGSVLISSW---- 158
Cdd:cd17339 48 AVFSPLAP-RLARRFGLERTLLLALLLLAAG--------ILLRSLGGIALLflgTALAGAGIAV----GNVLLPSLikrd 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 159 FPLSEKStAMAIFTTGNQIGIAVSMFLTAKLCQlHFFEGWPLVFIVYGLIGAVFLVIWHVRLADKPRESKyiTATELTYI 238
Cdd:cd17339 115 FPRRVGL-MTGLYTTSMNLGAALASGLSVPLAQ-ALGGGWRGALAIWALPALLALLIWLPQLRRRKRAAA--AAAPLTKI 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 239 KGGKQRRNRAETIvratpYMKIilngcvcaicacsfaQSFVLVALVTYLPKYnQIAFKMNLTHNGIWSSLPFFIQMITKL 318
Cdd:cd17339 191 SVWRSPLAWQVTL-----FMGL---------------QSLLFYTLMAWLPTI-LIDAGLSAATAGWLLSLFQLVGIPASL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 319 LFAIIADKVKQRKVNATAVTKVSnaIASFAsAIFIVIAAYGPFdsaeLVQLSIIVSMAAFSAYVpgYNTSIVTVAPQFTA 398
Cdd:cd17339 250 LVPILATRLKNQRPIVVLLAVLF--IIGVL-GLLFAPTALALL----WAVLLGLGGGAAFSLAL--TLISLRSSDPAEAA 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 25141316 399 FISSYAQLYAQIASTLAPIVIGRItsHGTIYEWKCAFYslagVLAVTGLIFQIFGHG 455
Cdd:cd17339 321 ALSGMAQSVGYLLAALGPLLFGVL--HDLTGSWTAPLV----LLLALTVLQLVAGLG 371
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
40-230 |
2.95e-04 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 43.52 E-value: 2.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 40 FGLMRTCFgMAMVD--IVRSGNGTFHPDLHMewSGDEQANIHTSFYIGAFIAVFPSEFLAKKLGPKNLLSFALLLNIFGS 117
Cdd:TIGR00711 5 IVLMLGTF-MAVLDstIVNVAIPTIAGDLGS--SLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 118 LLTPFSAiylrSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHffeG 197
Cdd:TIGR00711 82 LLCGVAP----NLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENY---H 154
|
170 180 190
....*....|....*....|....*....|....
gi 25141316 198 WPLVFIVYGLIGA-VFLVIWHVRLADKPRESKYI 230
Cdd:TIGR00711 155 WRWIFLINVPIGIiVVVVAFFILPRDKPAASENF 188
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
68-215 |
3.90e-04 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 42.95 E-value: 3.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 68 MEWSGDEQANIHTSFYIGA--FIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLLTPFSAIYLRSYFPVAAIRLIMGFGY- 144
Cdd:cd17315 207 FKSAGGGTASILASIIVGVvnLLATLVAIRLVDKVGRRPLLLIGFAGMAASLLLLAIAFLLPALAKAAGWLALLGILLYi 286
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 25141316 145 -GFVIPAGSV---LISSWFPLSEKSTAMAIFTTGNQI--GIAVSMFLTAKLCQlhffeGWPLVFIVYGLIGAVFLVI 215
Cdd:cd17315 287 aAFAMGAGPVpwlLLSEIFPLRIRGKGMAIATLVNWIfnFIVGLTFLIMVSTI-----GLAGVFIFFAAVCLLALVF 358
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
41-217 |
4.57e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 42.58 E-value: 4.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 41 GLMRTCFGMAMVDIVRSGNGTFHPdLHMEWSGDEQANIHTSFYIGAFIAVFP-SEFLAKKLGPKNLLSFALLLNIFGSLL 119
Cdd:cd17489 195 KVLPPALILFLASIAYGAISTFLP-LYAAERGISNAGLFFTVYAIALLLSRPfSGKLSDRKGPKTVIIPGLLLLALGLLL 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 120 tpFSAIYLRSYFPVAAIrlIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHffeGWP 199
Cdd:cd17489 274 --LSFAGSPWMLLLAAV--LYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELF---GYR 346
|
170
....*....|....*...
gi 25141316 200 LVFIVYGLIGAVFLVIWH 217
Cdd:cd17489 347 AMFLLAAVVVLLALVLYI 364
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
81-225 |
5.92e-04 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 42.26 E-value: 5.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 81 SFYIGAFIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLLTPFSaIYLRSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFP 160
Cdd:pfam00083 54 IFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAA-KGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAP 132
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 25141316 161 LSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHFFEGWPLVFIVyGLIGAVFLVIWHVRLADKPR 225
Cdd:pfam00083 133 KKLRGALGSLYQLAITFGILLAYIFGLGLNKTSNSDGWRIPLGL-QLVPALLLIIGLLFLPESPR 196
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
13-224 |
6.69e-04 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 42.39 E-value: 6.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 13 PSPIPPLWTLQSI-------RFQTALLISAACVVFGLMRTCFGMAMVDIVRSGnGTFHPDLHMewsgdeqanIHTSFYIG 85
Cdd:PRK11663 1 PADAPLITDKHEIdaryrywRRHILITMYLGYALFYFTRKSFNAAMPEMLADL-GLSRSDIGL---------LATLFYIT 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 86 AFIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLLTPFSAiylrSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKS 165
Cdd:PRK11663 71 YGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSS----SLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERG 146
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 25141316 166 TAMAIFTTGNQIGIAVSMFLTAKLcQLHFfeGWPLVFIVYGLIGAVFLVIWHVRLADKP 224
Cdd:PRK11663 147 GWWAIWNTAHNVGGALIPLVVGAI-ALHY--GWRYGMMIAGIIAIVVGLFLCWRLRDKP 202
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
82-215 |
6.83e-04 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 42.18 E-value: 6.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 82 FYIGAFIAVFPseFLAKKLGPKNLLSFALLLNIFGSLLTPFSAIYlrSYFPVAAIrlIMGFGYGFVIPAGSVLISSWFPL 161
Cdd:cd17330 222 AGILAQLLLIP--RLAKRLGERKLLRLGLLLAIIGLLLLPFASSV--PLLVLAAA--ILAFGTGIVFPALSALLSKSVPS 295
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 25141316 162 SEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHFFEGWPLVFIVYGLIGAVFLVI 215
Cdd:cd17330 296 KEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
96-449 |
8.28e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 41.87 E-value: 8.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 96 LAKKLGPKNLLSFALLLNIFGSLLTPFSAIYLRSYfpvAAIRLIMGFGYG-FVIPAGSVLISSWFPlSEKSTAMAIFTTG 174
Cdd:cd17355 61 LLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLY---LLWGLLGGGGAGtLAAVAFATVAAWWFE-RRRGLALGILTAG 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 175 NQIGIAVSMFLTAKLcqLHFFeGWPLVFIVYGLIGAVFLVIWHVRLADKPRESKYITATELTYIKGGKQRRNraetIVRA 254
Cdd:cd17355 137 GGLGSLVFLPLGAAL--IEAF-GWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGSTLKE----ALRS 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 255 TPYMKIILNGCVCAicacsFAQSFVLVALVTYLpkynqIAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKQRKVna 334
Cdd:cd17355 210 ASFWLLALAFFLCG-----FAVVGLIVHLVPYL-----ADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRL-- 277
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 335 tavtkvsNAIASFASAIFIVIAAYGPFDSAELVQLSIIVSMAAFsAYVPGYNTSIVTVAPQ-FTAFISSYAQLYAQIAST 413
Cdd:cd17355 278 -------LAASYALRALGLALLLLLPFPPLALLLFAALFGLGWG-ATVPLTAALAARYFGArSYGTLFGLVFAPHQLGSA 349
|
330 340 350
....*....|....*....|....*....|....*.
gi 25141316 414 LAPIVIGRITSHGTIYEWkcAFYSLAGVLAVTGLIF 449
Cdd:cd17355 350 LGPWLGGLLYDRTGSYTA--AWALAVALGLIAALLV 383
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
95-227 |
1.50e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 41.02 E-value: 1.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 95 FLAKKLGPKNLLSFALLLNIFGSLLTPFSAIYLRSYFPVAairLIMGFGYGFVIPAGSVLISSWFPLSEKSTAMAIFTTG 174
Cdd:COG2223 263 WLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLF---LLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAA 339
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 25141316 175 NQIGIAVSMFLTAKLCQLhfFEGWPLVFIVYGLIGAVFLVIWHVRLADKPRES 227
Cdd:COG2223 340 GGLGGFLGPLLFGALLDA--TGSYTAAFLVFAVLALVALVLTLLLYRRPRRAA 390
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
133-383 |
2.47e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 40.27 E-value: 2.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 133 VAAIRLIMGFGYGFVIPAGSVLISSWFP-LSEKSTAMAIFTTGNQIGIAVSMFLTAKLcqLHFF-----EGWPLVFIVYG 206
Cdd:COG2211 113 ALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGGLLASVLPPPL--VAAFggdaaLGYRLTALIFA 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 207 LIGAVFLVIWHVRLadkpRESKYITATELTYIKGGKQ-RRNRaetivratPYMKiilngcvcaICACSFAQSFVLVALVT 285
Cdd:COG2211 191 VLGLLAFLLTFFGT----KERPVPEEEKVSLKESLKAlLKNR--------PFLL---------LLLAYLLFFLALALVAA 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 286 YLPKYNQIAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKQRKVnatavtkvsNAIASFASAIFIVIAAYGPFDSAE 365
Cdd:COG2211 250 LLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKA---------FIIGLLLAALGLLLLFFLGPGNLW 320
|
250
....*....|....*...
gi 25141316 366 LVQLSIIVSMAAFSAYVP 383
Cdd:COG2211 321 LLLVLAALAGIGLGAILV 338
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
87-185 |
3.35e-03 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 40.08 E-value: 3.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 87 FIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLLTPFSAIYLRSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSEKST 166
Cdd:cd17334 53 VPGVFAFCWLLDKVGLRIGVLIGAALNALGSVLKCIPLGQQPKFALLVLGQVLNALAQVLVLSLPPLIAAVWFPPKERTT 132
|
90
....*....|....*....
gi 25141316 167 AMAIFTTGNQIGIAVSMFL 185
Cdd:cd17334 133 ATAIASLANFLGCAIGFLL 151
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
80-381 |
3.55e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 39.85 E-value: 3.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 80 TSFYIGAFIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLLTPFsaiyLRSYFPVAAIRLIMGFGYGFVIPAGSVLISSWF 159
Cdd:cd17477 38 SAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL----TDSPWVWFLLRFVMGIGLAGLFVVSESWLNALA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 160 PLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQlhffEGWPLVFIVYGLIGAVFLVIWHVRLADKPRESkyitateltyik 239
Cdd:cd17477 114 TNENRGRVLGLYSTVLGLGFALGPLLLALVGT----AGALPFLIAAVLLLLALVPLLLTRRAAPEIEE------------ 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 240 ggkQRRNRAETIVRATPymkiilngcvcAICACSFAQSFVLVALVTYLPKYnqiAFKMNLTHNGIWSSLPFFI--QMITK 317
Cdd:cd17477 178 ---AESISLRRLLRIAP-----------LALLGAFVAGFLEGAFYSLLPLY---GLRLGLSVAQAALLLAAFVlgGLLLQ 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 25141316 318 LLFAIIADKVKQRKVNATAvtkvsnAIASFASAIFIVIAAYGPFdsaELVQLSIIVSMAAFSAY 381
Cdd:cd17477 241 WPLGWLADRFDRRRVLLGC------ALLGALAALLLPLVPGLPL---ALLVLLFLWGGAAGPLY 295
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
269-449 |
3.98e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 39.71 E-value: 3.98e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 269 ICACSFAQSFVLVALVTYLPKYNQIAFKMNLTHNGIWSSLPFFIQMITKLLFAIIADKVKQRKVnatavtkvsnAIASFA 348
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRV----------LLIGLL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 349 SAIFIVIAAYGPFDSAELVQLSIIVSMAAFSAYVPGYNTSIVTVAPQFTAFISSYAQLYAQIASTLAPIVIGRITSHgti 428
Cdd:pfam07690 71 LFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL--- 147
|
170 180
....*....|....*....|.
gi 25141316 429 YEWKCAFYSLAGVLAVTGLIF 449
Cdd:pfam07690 148 FGWRAAFLILAILSLLAAVLL 168
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
86-440 |
4.07e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 39.48 E-value: 4.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 86 AFIAVFPSefLAKKLGPKNLLSFALLLNIFGSLLTPFSaiylRSYFPVAAIRLIMGFGYGfVIPAGSVLISSWFPLSEKS 165
Cdd:cd17504 46 VSTPILGR--LGDLYGRKKVLLIVLAIYTAGSLLAAFA----PNLPVLIAGRALQGIGGA-VFPLAFALVREEFPPERVP 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 166 TAMAIFTTGNQIGIAVSMFLTAKLCQlHFfeGWPLVFIVYGLIGAVFLVIwhVRLADkpreskyitateLTYIKggkqRR 245
Cdd:cd17504 119 VAQGILSATFGIGAGIGLPLGGWIVQ-HL--GWRWIFWTAAPVAVLLAAL--VPLID------------LRLLR----RR 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 246 NRAetivratpymkiILNGCVCAICACSFAQSFVLVALVTyLPKynQIAFKMNLTHNGIWSSLPFFIQMITKLLFAIIAD 325
Cdd:cd17504 178 NVL------------LANITALLAGFGMFMVFQLLPQLLQ-LPT--PTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIA 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 326 KVKQRKVnatavtkvsNAIASFASAIFIVIAAYGPFDSAELVQLSIIVSMAAFSAYVPGYNTSIVTVAPQFTAFISSYAQ 405
Cdd:cd17504 243 RVGPRRV---------LLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNT 313
|
330 340 350
....*....|....*....|....*....|....*
gi 25141316 406 LYAQIASTLAPIVIGRITSHGTIYEWKCAFYSLAG 440
Cdd:cd17504 314 VLRTIGSAIGPAIAGAILTTYTVSITSGGVPTEGA 348
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
71-186 |
4.21e-03 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 39.60 E-value: 4.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 71 SGDEQANIHTSFYIGAFIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLLTPFSAIYlrSYFPVAAIRLIMGFGYGFVIPA 150
Cdd:pfam13347 257 NGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALALLLGPN--NTLLFLVLYIIIGFGYGSSFFL 334
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 25141316 151 GSVLISSWFPLSE-------KSTAMAIFTTGNQIGIAVSMFLT 186
Cdd:pfam13347 335 PWSMLADVVDYGElrtgkrrEGTFFAMWSFISKLATGVGLGVS 377
|
|
| MFS_DIRC2 |
cd17397 |
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; ... |
83-215 |
4.23e-03 |
|
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; Disrupted in renal carcinoma protein 2 or disrupted in renal cancer protein 2 (DIRC2), encoded by the SLC49A4 gene, was initially identified as a breakpoint-spanning gene in a chromosomal translocation associated with the development of renal cancer. It is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. DIRC2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340955 [Multi-domain] Cd Length: 381 Bit Score: 39.59 E-value: 4.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 83 YIGAFIAVFPSEFLAKKLGpknlLSFALLLNIFgsLLTPFSAIYLRSYFPVAAIRLI------MGFGYGFVIPAGSVLIS 156
Cdd:cd17397 49 PIGFVPTFFFMAWLMDVKG----LRIAVLSSAF--LVAAGTGLRCIPVPNHLATWLIhigqflNGLAGPVAMAAAPFLSA 122
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 25141316 157 SWFPLSEKSTAMAIFTTGNQIGIAVSmFLTAKLcqlhffegwPLVFIVYGLIGAVFLVI 215
Cdd:cd17397 123 TWFPPNQRATATAIASIFNYLGGAAS-FLIGPL---------VLMYLEFGWSALIFLAM 171
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
84-181 |
5.37e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 39.10 E-value: 5.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 84 IGAFIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLLTPFSAIYLrSYFPVAAIRLIMGFGYGFVIPAGSVLISSWFPLSE 163
Cdd:cd17503 225 LASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLAFLTPDT-SLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQ 303
|
90
....*....|....*...
gi 25141316 164 KSTAMAIFTTGNQIGIAV 181
Cdd:cd17503 304 IGDATALFNTIRQLGGSI 321
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
71-215 |
6.06e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 39.12 E-value: 6.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 71 SGDEQANIHTSFYIGAFIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLLTPFSAIYLRSYfpVAAIRLIMGFGYGFVIPA 150
Cdd:cd17316 211 SPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTL--LLLLLFILSFFVGGVWGA 288
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 25141316 151 GSVLISSWFPLSEKSTAMAIFTTGNQIGIAVSMFLTAKLCQLHFFEGWPLVFIVYGLIGAVFLVI 215
Cdd:cd17316 289 LYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
59-180 |
7.60e-03 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 38.84 E-value: 7.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 59 NGTFHPDLHMEW---SGDE--QANIHTSFYIGAFIAVFPSEFLAKKLGPKNllsfALLLNIFGSLLTPFSAIYLRSYFPV 133
Cdd:TIGR00898 108 YDTFSSTIVTEWdlvCEDAwkVDLTQSCFFVGVLLGSFVFGYLSDRFGRKK----VLLLSTLVTAVSGVLTAFSPNYTVF 183
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 25141316 134 AAIRLIMGFGYGFVIPAGSVLISSWFPLSEK---STAMAIFTTGNQIGIA 180
Cdd:TIGR00898 184 LVFRLLVGMGIGGIWVQAVVLNTEFLPKKQRaivGTLIQVFFSLGLVLLP 233
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
84-183 |
7.75e-03 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 38.78 E-value: 7.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25141316 84 IGAFIAVFPSEFLAKKLGPKNLLSFALLLNIFGSLL---TPFSAIYLRSYFPVAairLIMGFGYGFVIPAGSVLISSWFP 160
Cdd:cd17476 223 IGGVLAAITVGFLIARLPPSYIMAISMVAFLVGPILfatMPVHQTYWAQAFPAM---IVAPFGMDFSFPAATIIASNAVP 299
|
90 100
....*....|....*....|...
gi 25141316 161 LSEKSTAMAIFTTGNQIGIAVSM 183
Cdd:cd17476 300 REYQGLAGSLVNTVVNYGISIGL 322
|
|
| |
