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Conserved domains on  [gi|392885143|ref|NP_491159|]
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CUB domain-containing protein [Caenorhabditis elegans]

Protein Classification

neuropilin and tolloid-like protein( domain architecture ID 10035862)

neuropilin and tolloid-like protein is a CUB and LDLa (low-density lipoprotein receptor class A) domain-containing protein similar to Homo sapiens neuropilin and tolloid-like protein 1 involved in the development and/or maintenance of neuronal circuitry

Gene Ontology:  GO:0045202|GO:0098696

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 39-147 5.19e-26

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 100.56  E-value: 5.19e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392885143  39 IFTSPNFPDRYPPNIDCVRVIHSRPQHDVVVKFHHvFHIESTYDkidageeCPNDFIEFRDGRYGFSPLIARFCGDRMPk 118
Cdd:cd00041   12 TISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFED-FDLESSPN-------CSYDYLEIYDGPSTSSPLLGRFCGSTLP- 82

                         90       100
                 ....*....|....*....|....*....
gi 392885143 119 REIRAVSGFLWIRFRSDSMLEYQGFSAEY 147
Cdd:cd00041   83 PPIISSGNSLTVRFRSDSSVTGRGFKATY 111
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 182-278 5.80e-17

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 75.91  E-value: 5.80e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392885143 182 NLPRNASGTLDCVWRLAVPNNFRIAFYVKEFALTAPNQCAHNFVEVYSGDTSNKP-LRRFCGLTANDVF-SPSNEMFVRF 259
Cdd:cd00041   17 NYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPlLGRFCGSTLPPPIiSSGNSLTVRF 96

                         90
                 ....*....|....*....
gi 392885143 260 YlSDvRSLNTTSISALFSS 278
Cdd:cd00041   97 R-SD-SSVTGRGFKATYSA 113
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 291-320 6.59e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 42.58  E-value: 6.59e-06
                         10        20        30
                 ....*....|....*....|....*....|
gi 392885143 291 FACGDENCVPKSLACNGRPNCPYGRDERVC 320
Cdd:cd00112    6 FRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 39-147 5.19e-26

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 100.56  E-value: 5.19e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392885143  39 IFTSPNFPDRYPPNIDCVRVIHSRPQHDVVVKFHHvFHIESTYDkidageeCPNDFIEFRDGRYGFSPLIARFCGDRMPk 118
Cdd:cd00041   12 TISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFED-FDLESSPN-------CSYDYLEIYDGPSTSSPLLGRFCGSTLP- 82

                         90       100
                 ....*....|....*....|....*....
gi 392885143 119 REIRAVSGFLWIRFRSDSMLEYQGFSAEY 147
Cdd:cd00041   83 PPIISSGNSLTVRFRSDSSVTGRGFKATY 111
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 39-147 7.32e-26

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 99.77  E-value: 7.32e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392885143    39 IFTSPNFPDRYPPNIDCVRVIHSRPQHDVVVKFHHvFHIESTYDkidageeCPNDFIEFRDGRYGFSPLIARFCGDRMPK 118
Cdd:smart00042   2 TITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTD-FDLESSDN-------CEYDYVEIYDGPSASSPLLGRFCGSEAPP 73

                           90       100
                   ....*....|....*....|....*....
gi 392885143   119 REIRAVSGFLWIRFRSDSMLEYQGFSAEY 147
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
40-147 1.82e-24

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 96.21  E-value: 1.82e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392885143   40 FTSPNFPDRYPPNIDCVRVIHSRPQHDVVVKFHHvFHIESTydkidagEECPNDFIEFRDGRYGFSPLIARFCGDRMPKr 119
Cdd:pfam00431  12 ISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQD-FELEDH-------DECGYDYVEIRDGPSASSPLLGRFCGSGIPE- 82

                          90       100
                  ....*....|....*....|....*...
gi 392885143  120 EIRAVSGFLWIRFRSDSMLEYQGFSAEY 147
Cdd:pfam00431  83 DIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 182-278 5.80e-17

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 75.91  E-value: 5.80e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392885143 182 NLPRNASGTLDCVWRLAVPNNFRIAFYVKEFALTAPNQCAHNFVEVYSGDTSNKP-LRRFCGLTANDVF-SPSNEMFVRF 259
Cdd:cd00041   17 NYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPlLGRFCGSTLPPPIiSSGNSLTVRF 96

                         90
                 ....*....|....*....
gi 392885143 260 YlSDvRSLNTTSISALFSS 278
Cdd:cd00041   97 R-SD-SSVTGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 182-259 4.57e-13

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 64.72  E-value: 4.57e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392885143   182 NLPRNASGTLDCVWRLAVPNNFRIAFYVKEFALTAPNQCAHNFVEVYSGD-TSNKPLRRFCGLTANDVF--SPSNEMFVR 258
Cdd:smart00042   7 NYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPsASSPLLGRFCGSEAPPPVisSSSNSLTLT 86


                   .
gi 392885143   259 F 259
Cdd:smart00042  87 F 87
CUB pfam00431
CUB domain;
182-266 1.32e-12

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 63.47  E-value: 1.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392885143  182 NLPRNASGTLDCVWRLAVPNNFRIAFYVKEFALTAPNQCAHNFVEVYSGDTSNKPLR-RFCGLTA-NDVFSPSNEMFVRF 259
Cdd:pfam00431  16 NYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLgRFCGSGIpEDIVSSSNQMTIKF 95


                  ....*..
gi 392885143  260 YLSDVRS 266
Cdd:pfam00431  96 VSDASVQ 102
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 291-320 6.59e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 42.58  E-value: 6.59e-06
                         10        20        30
                 ....*....|....*....|....*....|
gi 392885143 291 FACGDENCVPKSLACNGRPNCPYGRDERVC 320
Cdd:cd00112    6 FRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
291-320 2.98e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 38.00  E-value: 2.98e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 392885143  291 FACGDENCVPKSLACNGRPNCPYGRDERVC 320
Cdd:pfam00057   8 FQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 288-317 9.62e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 36.46  E-value: 9.62e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 392885143   288 EGLFACGDENCVPKSLACNGRPNCPYGRDE 317
Cdd:smart00192   4 PGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 39-147 5.19e-26

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 100.56  E-value: 5.19e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392885143  39 IFTSPNFPDRYPPNIDCVRVIHSRPQHDVVVKFHHvFHIESTYDkidageeCPNDFIEFRDGRYGFSPLIARFCGDRMPk 118
Cdd:cd00041   12 TISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFED-FDLESSPN-------CSYDYLEIYDGPSTSSPLLGRFCGSTLP- 82

                         90       100
                 ....*....|....*....|....*....
gi 392885143 119 REIRAVSGFLWIRFRSDSMLEYQGFSAEY 147
Cdd:cd00041   83 PPIISSGNSLTVRFRSDSSVTGRGFKATY 111
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 39-147 7.32e-26

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 99.77  E-value: 7.32e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392885143    39 IFTSPNFPDRYPPNIDCVRVIHSRPQHDVVVKFHHvFHIESTYDkidageeCPNDFIEFRDGRYGFSPLIARFCGDRMPK 118
Cdd:smart00042   2 TITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTD-FDLESSDN-------CEYDYVEIYDGPSASSPLLGRFCGSEAPP 73

                           90       100
                   ....*....|....*....|....*....
gi 392885143   119 REIRAVSGFLWIRFRSDSMLEYQGFSAEY 147
Cdd:smart00042  74 PVISSSSNSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
40-147 1.82e-24

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 96.21  E-value: 1.82e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392885143   40 FTSPNFPDRYPPNIDCVRVIHSRPQHDVVVKFHHvFHIESTydkidagEECPNDFIEFRDGRYGFSPLIARFCGDRMPKr 119
Cdd:pfam00431  12 ISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQD-FELEDH-------DECGYDYVEIRDGPSASSPLLGRFCGSGIPE- 82

                          90       100
                  ....*....|....*....|....*...
gi 392885143  120 EIRAVSGFLWIRFRSDSMLEYQGFSAEY 147
Cdd:pfam00431  83 DIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 182-278 5.80e-17

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 75.91  E-value: 5.80e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392885143 182 NLPRNASGTLDCVWRLAVPNNFRIAFYVKEFALTAPNQCAHNFVEVYSGDTSNKP-LRRFCGLTANDVF-SPSNEMFVRF 259
Cdd:cd00041   17 NYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTSSPlLGRFCGSTLPPPIiSSGNSLTVRF 96

                         90
                 ....*....|....*....
gi 392885143 260 YlSDvRSLNTTSISALFSS 278
Cdd:cd00041   97 R-SD-SSVTGRGFKATYSA 113
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 182-259 4.57e-13

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 64.72  E-value: 4.57e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392885143   182 NLPRNASGTLDCVWRLAVPNNFRIAFYVKEFALTAPNQCAHNFVEVYSGD-TSNKPLRRFCGLTANDVF--SPSNEMFVR 258
Cdd:smart00042   7 NYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPsASSPLLGRFCGSEAPPPVisSSSNSLTLT 86


                   .
gi 392885143   259 F 259
Cdd:smart00042  87 F 87
CUB pfam00431
CUB domain;
182-266 1.32e-12

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 63.47  E-value: 1.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392885143  182 NLPRNASGTLDCVWRLAVPNNFRIAFYVKEFALTAPNQCAHNFVEVYSGDTSNKPLR-RFCGLTA-NDVFSPSNEMFVRF 259
Cdd:pfam00431  16 NYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPSASSPLLgRFCGSGIpEDIVSSSNQMTIKF 95


                  ....*..
gi 392885143  260 YLSDVRS 266
Cdd:pfam00431  96 VSDASVQ 102
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 291-320 6.59e-06

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 42.58  E-value: 6.59e-06
                         10        20        30
                 ....*....|....*....|....*....|
gi 392885143 291 FACGDENCVPKSLACNGRPNCPYGRDERVC 320
Cdd:cd00112    6 FRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
291-320 2.98e-04

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 38.00  E-value: 2.98e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 392885143  291 FACGDENCVPKSLACNGRPNCPYGRDERVC 320
Cdd:pfam00057   8 FQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 288-317 9.62e-04

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 36.46  E-value: 9.62e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 392885143   288 EGLFACGDENCVPKSLACNGRPNCPYGRDE 317
Cdd:smart00192   4 PGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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