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Conserved domains on  [gi|71996985|ref|NP_491846|]
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BUB1 N-terminal domain-containing protein [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mad3_BUB1_I super family cl07066
Mad3/BUB1 homology region 1; Proteins containing this domain are checkpoint proteins involved ...
 80-180 3.64e-26

Mad3/BUB1 homology region 1; Proteins containing this domain are checkpoint proteins involved in cell division. This region has been shown to be essential for the binding of the binding of BUB1 and MAD3 to CDC20p.


The actual alignment was detected with superfamily member smart00777:

Pssm-ID: 471584  Cd Length: 124  Bit Score: 101.53  E-value: 3.64e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71996985     80 ILDFCSWFEEKLAIGF-HKVYYELLWKIISRHGFLEKYKEDERMLKIWEKMADNSaGHAHDIYQFAISRKSLVKCAALYA 158
Cdd:smart00777  24 WLRYIKWTEENYPQGGkESGLLTLLERCIRYFEDDERYKNDPRYLKIWLKYAEYC-DEPRELFQFLYSKGIGTKLALFYE 102

                           90       100
                   ....*....|....*....|..
gi 71996985    159 RWSQSVELAGAYVEARRVLILA 180
Cdd:smart00777 103 EWAQLLEAAGRYKKADEVYQLG 124
 
Name Accession Description Interval E-value
Mad3_BUB1_I smart00777
Mad3/BUB1 hoMad3/BUB1 homology region 1; Proteins containing this domain are checkpoint ...
 80-180 3.64e-26

Mad3/BUB1 hoMad3/BUB1 homology region 1; Proteins containing this domain are checkpoint proteins involved in cell division. This region has been shown to be essential for the binding of the binding of BUB1 and MAD3 to CDC20p.


Pssm-ID: 214817  Cd Length: 124  Bit Score: 101.53  E-value: 3.64e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71996985     80 ILDFCSWFEEKLAIGF-HKVYYELLWKIISRHGFLEKYKEDERMLKIWEKMADNSaGHAHDIYQFAISRKSLVKCAALYA 158
Cdd:smart00777  24 WLRYIKWTEENYPQGGkESGLLTLLERCIRYFEDDERYKNDPRYLKIWLKYAEYC-DEPRELFQFLYSKGIGTKLALFYE 102

                           90       100
                   ....*....|....*....|..
gi 71996985    159 RWSQSVELAGAYVEARRVLILA 180
Cdd:smart00777 103 EWAQLLEAAGRYKKADEVYQLG 124
Mad3_BUB1_I pfam08311
Mad3/BUB1 homology region 1; Proteins containing this domain are checkpoint proteins involved ...
 78-180 2.95e-22

Mad3/BUB1 homology region 1; Proteins containing this domain are checkpoint proteins involved in cell division. This region has been shown to be essential for the binding of the binding of BUB1 and MAD3 to CDC20p.


Pssm-ID: 462420  Cd Length: 123  Bit Score: 91.05  E-value: 2.95e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71996985    78 QKILDFCSWFEEKLAI-GFHKVYYELLWKIISRHGFLEKYKEDERMLKIWEKMADNSaGHAHDIYQFAISRKSLVKCAAL 156
Cdd:pfam08311  20 EPWLRYIKWTEESYPQgGKESGLLELLERCTRYFKDDERYKNDPRYLKLWLKYADFC-DDPRDIFQFLYSNGIGTKLALF 98

                          90       100
                  ....*....|....*....|....
gi 71996985   157 YARWSQSVELAGAYVEARRVLILA 180
Cdd:pfam08311  99 YEEWAELLERQGRFKEADEIYQLG 122
 
Name Accession Description Interval E-value
Mad3_BUB1_I smart00777
Mad3/BUB1 hoMad3/BUB1 homology region 1; Proteins containing this domain are checkpoint ...
 80-180 3.64e-26

Mad3/BUB1 hoMad3/BUB1 homology region 1; Proteins containing this domain are checkpoint proteins involved in cell division. This region has been shown to be essential for the binding of the binding of BUB1 and MAD3 to CDC20p.


Pssm-ID: 214817  Cd Length: 124  Bit Score: 101.53  E-value: 3.64e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71996985     80 ILDFCSWFEEKLAIGF-HKVYYELLWKIISRHGFLEKYKEDERMLKIWEKMADNSaGHAHDIYQFAISRKSLVKCAALYA 158
Cdd:smart00777  24 WLRYIKWTEENYPQGGkESGLLTLLERCIRYFEDDERYKNDPRYLKIWLKYAEYC-DEPRELFQFLYSKGIGTKLALFYE 102

                           90       100
                   ....*....|....*....|..
gi 71996985    159 RWSQSVELAGAYVEARRVLILA 180
Cdd:smart00777 103 EWAQLLEAAGRYKKADEVYQLG 124
Mad3_BUB1_I pfam08311
Mad3/BUB1 homology region 1; Proteins containing this domain are checkpoint proteins involved ...
 78-180 2.95e-22

Mad3/BUB1 homology region 1; Proteins containing this domain are checkpoint proteins involved in cell division. This region has been shown to be essential for the binding of the binding of BUB1 and MAD3 to CDC20p.


Pssm-ID: 462420  Cd Length: 123  Bit Score: 91.05  E-value: 2.95e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71996985    78 QKILDFCSWFEEKLAI-GFHKVYYELLWKIISRHGFLEKYKEDERMLKIWEKMADNSaGHAHDIYQFAISRKSLVKCAAL 156
Cdd:pfam08311  20 EPWLRYIKWTEESYPQgGKESGLLELLERCTRYFKDDERYKNDPRYLKLWLKYADFC-DDPRDIFQFLYSNGIGTKLALF 98

                          90       100
                  ....*....|....*....|....
gi 71996985   157 YARWSQSVELAGAYVEARRVLILA 180
Cdd:pfam08311  99 YEEWAELLERQGRFKEADEIYQLG 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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