NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|25149766|ref|NP_492193|]
View 

Junctophilin-1 [Caenorhabditis elegans]

Protein Classification

MORN repeat-containing protein( domain architecture ID 10494539)

membrane-occupation-and-recognition-nexus (MORN) repeat-containing protein may be involved in protein-protein interactions

PubMed:  33296386|35568981

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
2-145 9.26e-24

Uncharacterized conserved protein [Function unknown];


:

Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 101.57  E-value: 9.26e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25149766   2 NGGRFDFDDGGTYVGGWEEGKAHGHGVCTGPQAKGEYAGAWHYGFEVSGVYTWPSGNTYQGQWQNGKRHGLGIEQ--RGR 79
Cdd:COG4642  92 GGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTyaDGD 171

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 25149766  80 WlYKGEWTQGYKGRYGVRQSANsQARYQGTWSAGFHDGYGTEIYVDSGSYQGQWLRGMRHGYGIRK 145
Cdd:COG4642 172 R-YEGEFKNGKRHGQGTLTYAN-GDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLT 235
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 306-328 2.49e-03

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


:

Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 35.85  E-value: 2.49e-03
                          10        20
                  ....*....|....*....|...
gi 25149766   306 YQGEWANNAKCGYGVTTFKDGTK 328
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 283-303 3.44e-03

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


:

Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 35.46  E-value: 3.44e-03
                          10        20
                  ....*....|....*....|.
gi 25149766   283 YMGEWKNDMRSGFGVCERSDG 303
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDG 21
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
2-145 9.26e-24

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 101.57  E-value: 9.26e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25149766   2 NGGRFDFDDGGTYVGGWEEGKAHGHGVCTGPQAKGEYAGAWHYGFEVSGVYTWPSGNTYQGQWQNGKRHGLGIEQ--RGR 79
Cdd:COG4642  92 GGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTyaDGD 171

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 25149766  80 WlYKGEWTQGYKGRYGVRQSANsQARYQGTWSAGFHDGYGTEIYVDSGSYQGQWLRGMRHGYGIRK 145
Cdd:COG4642 172 R-YEGEFKNGKRHGQGTLTYAN-GDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLT 235
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 4-143 4.76e-21

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 98.37  E-value: 4.76e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25149766    4 GRFDFDDGGTYVGGWEEGKAHGHGVCTGPQA---KGEYAGAWHYGfevSGVYTWPSGNTYQGQWQNGKRHGLGieqRGRW 80
Cdd:PLN03185  24 GKYLWSDGCMYEGEWRRGMRHGNGKISWPSGatyEGEFSGGYMHG---SGTYTGTDGTTYKGRWRLNLKHGLG---YQRY 97

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 25149766   81 ----LYKGEWTQGYKGRYGVRQSANSQArYQGTWSAGFHDGYGTEIYVDSGSYQGQWLRGMRHGYGI 143
Cdd:PLN03185  98 pngdVFEGSWIQGLQEGPGKYTWANGNV-YLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGV 163
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
58-74 9.70e-04

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 36.93  E-value: 9.70e-04
                           10
                   ....*....|....*..
gi 25149766     58 NTYQGQWQNGKRHGLGI 74
Cdd:smart00698   1 DRYEGEWRNGKRHGRGV 17
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 306-328 2.49e-03

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 35.85  E-value: 2.49e-03
                          10        20
                  ....*....|....*....|...
gi 25149766   306 YQGEWANNAKCGYGVTTFKDGTK 328
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 283-303 3.44e-03

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 35.46  E-value: 3.44e-03
                          10        20
                  ....*....|....*....|.
gi 25149766   283 YMGEWKNDMRSGFGVCERSDG 303
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDG 21
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
2-145 9.26e-24

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 101.57  E-value: 9.26e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25149766   2 NGGRFDFDDGGTYVGGWEEGKAHGHGVCTGPQAKGEYAGAWHYGFEVSGVYTWPSGNTYQGQWQNGKRHGLGIEQ--RGR 79
Cdd:COG4642  92 GGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTyaDGD 171

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 25149766  80 WlYKGEWTQGYKGRYGVRQSANsQARYQGTWSAGFHDGYGTEIYVDSGSYQGQWLRGMRHGYGIRK 145
Cdd:COG4642 172 R-YEGEFKNGKRHGQGTLTYAN-GDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLT 235
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
1-133 1.87e-21

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 95.02  E-value: 1.87e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25149766   1 MNG-GRFDFDDGGTYVGGWEEGKAHGHGVCTgpQAKGE-YAGAWHYG-FEVSGVYTWPSGNTYQGQWQNGKRHGLGIEqr 77
Cdd:COG4642 159 PHGqGTLTYADGDRYEGEFKNGKRHGQGTLT--YANGDvYEGEFKNGqRHGQGTYTYADGDRYEGEFKNGKRHGQGTL-- 234

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 25149766  78 grwlykgEWTQGYkgrygvrqsansqaRYQGTWSAGFHDGYGTEIYVDSGSYQGQW 133
Cdd:COG4642 235 -------TYADGD--------------RYEGEFKNGKRHGQGTMTYADGSVYEGEW 269
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 4-143 4.76e-21

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 98.37  E-value: 4.76e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25149766    4 GRFDFDDGGTYVGGWEEGKAHGHGVCTGPQA---KGEYAGAWHYGfevSGVYTWPSGNTYQGQWQNGKRHGLGieqRGRW 80
Cdd:PLN03185  24 GKYLWSDGCMYEGEWRRGMRHGNGKISWPSGatyEGEFSGGYMHG---SGTYTGTDGTTYKGRWRLNLKHGLG---YQRY 97

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 25149766   81 ----LYKGEWTQGYKGRYGVRQSANSQArYQGTWSAGFHDGYGTEIYVDSGSYQGQWLRGMRHGYGI 143
Cdd:PLN03185  98 pngdVFEGSWIQGLQEGPGKYTWANGNV-YLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGV 163
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
9-338 2.85e-16

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 79.62  E-value: 2.85e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25149766   9 DDGGTYVGGWEEGKAHGHGVCTGPQAKGEYAGAWHYGFEVSGVYTWPSGNTYQGQWQNGKRHGLGI-------------E 75
Cdd:COG4642  41 PGGGGYGGGADGGGGGGGGTGVAGGGGGEGGVTAAGGGGGGGGGKGDGGDGGGGEGGFGGGGGGGGgkkggggggggvlE 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25149766  76 QRGRWLYKGEWTQGYKGRYGVRQSANSqARYQGTWSAGFHDGYGTEIYVDSGSYQGQWLRGMRHGYGIRKsttyekaakf 155
Cdd:COG4642 121 GDDGGGYGGGTADGGRGGGGIYTFPNG-DVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLT---------- 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25149766 156 rsksqthasltslrsgrveeenaaeehrhkeglsgrggfvlranssapqrrrrslserslavkrtllsglrikkqHSTGD 235
Cdd:COG4642 190 ---------------------------------------------------------------------------YANGD 194

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25149766 236 IhqrvasmtgslrssgstmsctsedslhhhglqqpeeeaveessietYMGEWKNDMRSGFGVCERSDGLKYQGEWANNAK 315
Cdd:COG4642 195 V----------------------------------------------YEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKR 228

                       330       340
                ....*....|....*....|...
gi 25149766 316 CGYGVTTFKDGTKEEGRYKNNIL 338
Cdd:COG4642 229 HGQGTLTYADGDRYEGEFKNGKR 251
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
1-66 4.48e-09

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 58.04  E-value: 4.48e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 25149766   1 MNG-GRFDFDDGGTYVGGWEEGKAHGHGVCTGpqAKGE-YAGAWHYG-FEVSGVYTWPSGNTYQGQWQN 66
Cdd:COG4642 205 RHGqGTYTYADGDRYEGEFKNGKRHGQGTLTY--ADGDrYEGEFKNGkRHGQGTMTYADGSVYEGEWKN 271
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 38-327 7.74e-08

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 55.99  E-value: 7.74e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25149766   38 YAGAWHYGF-EVSGVYTWPSGNTYQGQWQNGKRHGLGieqrgrwlyKGEWTQGykgrygvrqsansqARYQGTWSAGFHD 116
Cdd:PLN03185  11 YSGSLLGNVpEGPGKYLWSDGCMYEGEWRRGMRHGNG---------KISWPSG--------------ATYEGEFSGGYMH 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25149766  117 GYGTEIYVDSGSYQGQWLRGMRHGYGirksttyekaakfrsksqthasltslrsgrveeenaaeehrhkeglsgrggfvl 196
Cdd:PLN03185  68 GSGTYTGTDGTTYKGRWRLNLKHGLG------------------------------------------------------ 93

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25149766  197 ranssapqrrrrslserslavkrtllsglriKKQHSTGDIHQrvasmtGSLRssgstmsctsedslhhhglqQPEEEAVE 276
Cdd:PLN03185  94 -------------------------------YQRYPNGDVFE------GSWI--------------------QGLQEGPG 116

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 25149766  277 E---SSIETYMGEWKNDMRSGFGVCERSDGLKYQGEWANNAKCGYGVTTFKDGT 327
Cdd:PLN03185 117 KytwANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGG 170
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
58-74 9.70e-04

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 36.93  E-value: 9.70e-04
                           10
                   ....*....|....*..
gi 25149766     58 NTYQGQWQNGKRHGLGI 74
Cdd:smart00698   1 DRYEGEWRNGKRHGRGV 17
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 306-328 2.49e-03

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 35.85  E-value: 2.49e-03
                          10        20
                  ....*....|....*....|...
gi 25149766   306 YQGEWANNAKCGYGVTTFKDGTK 328
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 283-303 3.44e-03

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 35.46  E-value: 3.44e-03
                          10        20
                  ....*....|....*....|.
gi 25149766   283 YMGEWKNDMRSGFGVCERSDG 303
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDG 21
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
128-143 8.07e-03

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 34.24  E-value: 8.07e-03
                           10
                   ....*....|....*.
gi 25149766    128 SYQGQWLRGMRHGYGI 143
Cdd:smart00698   2 RYEGEWRNGKRHGRGV 17
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH