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Conserved domains on  [gi|17506363|ref|NP_492303|]
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Cell division cycle 5-like protein [Caenorhabditis elegans]

Protein Classification

pre-mRNA-splicing factor CEF1 family protein( domain architecture ID 13419721)

pre-mRNA-splicing factor CEF1 family protein is a SANT/Myb-like DNA-binding domain-containing protein, similar to CEF1 that is involved in pre-mRNA splicing and cell cycle control

CATH:  1.20.58.1880
Gene Ontology:  GO:0003677
PubMed:  8882580
SCOP:  4000317

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
REB1 super family cl34920
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 2-197 2.85e-42

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5147:

Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 161.11  E-value: 2.85e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506363   2 VRVIIKGGVWKNTEDEILKAAIMKYGKNQWSRIASLLHRKSAKQCKARWFEWLDPGIKKTEWSREEDEKLLHLAKLMPTQ 81
Cdd:COG5147  14 MQTKRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQ 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506363  82 WRTIAPIV-GRTSAQCLERYEHLLDEAQrKAEGLDEEatetRKLKPGEIDPTPETKPARPDPIDMDDDELEMLSEARARL 160
Cdd:COG5147  94 WSTIADYKdRRTAQQCVERYVNTLEDLS-STHDSKLQ----RRNEFDKIDPFNENSARRPDIYEDELLEREVNREASYRL 168

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 17506363 161 ANTQGKKAKRKARERQLSDARRLASLQKRREMRAAGL 197
Cdd:COG5147 169 RVPRVSKADVKPREKGEENNPDIEDLQEMKELKSASI 205
Myb_Cef pfam11831
pre-mRNA splicing factor component; This family is a region of the Myb-Related Cdc5p/Cef1 ...
 397-590 3.99e-35

pre-mRNA splicing factor component; This family is a region of the Myb-Related Cdc5p/Cef1 proteins, in fungi, and is part of the pre-mRNA splicing factor complex.


:

Pssm-ID: 463366  Cd Length: 227  Bit Score: 133.16  E-value: 3.99e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506363   397 TPNTVlhaiaATPGTQSQ-FPGSTP--GGFATPAGsvaaTPFRDQMRINEEIAGSA-----------LEQKASLKRALAS 462
Cdd:pfam11831   1 TPNPL-----ATPFRTGNgGVGATPrrGFGATPLR----TPLRDKLNINPEDGMLVgetprdekqrqKEAKEQLRSGLAS 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506363   463 LPTPKNDFEVVGPDDDEVEGAVEDESNQdedgwIEDASER-AENKAKRNAEnRVRNMKMRSQVIQRSLPKPTKVNEQATR 541
Cdd:pfam11831  72 LPKPKNDFEIVLPEEEEEESETEAVEDS-----EEDAAERdAREQAEREAE-EEKELARRSQVVQRGLPRPSEVNLDVLR 145

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17506363   542 ATNSS--------ADDMVKAEMSKLLAWDVDNKPPSVI------------YSREELDAAADLIKQEAES 590
Cdd:pfam11831 146 PANDEppltdlqpAEELIKKEMATLLHHDALKYPLPGAaqpyleaspyedFSDEELAAAKELIAAEMAV 214
 
Name Accession Description Interval E-value
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 2-197 2.85e-42

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 161.11  E-value: 2.85e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506363   2 VRVIIKGGVWKNTEDEILKAAIMKYGKNQWSRIASLLHRKSAKQCKARWFEWLDPGIKKTEWSREEDEKLLHLAKLMPTQ 81
Cdd:COG5147  14 MQTKRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQ 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506363  82 WRTIAPIV-GRTSAQCLERYEHLLDEAQrKAEGLDEEatetRKLKPGEIDPTPETKPARPDPIDMDDDELEMLSEARARL 160
Cdd:COG5147  94 WSTIADYKdRRTAQQCVERYVNTLEDLS-STHDSKLQ----RRNEFDKIDPFNENSARRPDIYEDELLEREVNREASYRL 168

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 17506363 161 ANTQGKKAKRKARERQLSDARRLASLQKRREMRAAGL 197
Cdd:COG5147 169 RVPRVSKADVKPREKGEENNPDIEDLQEMKELKSASI 205
Myb_Cef pfam11831
pre-mRNA splicing factor component; This family is a region of the Myb-Related Cdc5p/Cef1 ...
 397-590 3.99e-35

pre-mRNA splicing factor component; This family is a region of the Myb-Related Cdc5p/Cef1 proteins, in fungi, and is part of the pre-mRNA splicing factor complex.


Pssm-ID: 463366  Cd Length: 227  Bit Score: 133.16  E-value: 3.99e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506363   397 TPNTVlhaiaATPGTQSQ-FPGSTP--GGFATPAGsvaaTPFRDQMRINEEIAGSA-----------LEQKASLKRALAS 462
Cdd:pfam11831   1 TPNPL-----ATPFRTGNgGVGATPrrGFGATPLR----TPLRDKLNINPEDGMLVgetprdekqrqKEAKEQLRSGLAS 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506363   463 LPTPKNDFEVVGPDDDEVEGAVEDESNQdedgwIEDASER-AENKAKRNAEnRVRNMKMRSQVIQRSLPKPTKVNEQATR 541
Cdd:pfam11831  72 LPKPKNDFEIVLPEEEEEESETEAVEDS-----EEDAAERdAREQAEREAE-EEKELARRSQVVQRGLPRPSEVNLDVLR 145

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17506363   542 ATNSS--------ADDMVKAEMSKLLAWDVDNKPPSVI------------YSREELDAAADLIKQEAES 590
Cdd:pfam11831 146 PANDEppltdlqpAEELIKKEMATLLHHDALKYPLPGAaqpyleaspyedFSDEELAAAKELIAAEMAV 214
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 56-108 1.04e-29

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 111.63  E-value: 1.04e-29
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 17506363  56 PGIKKTEWSREEDEKLLHLAKLMPTQWRTIAPIVGRTSAQCLERYEHLLDEAQ 108
Cdd:cd11659   1 PSIKKTEWTREEDEKLLHLAKLLPTQWRTIAPIVGRTAQQCLERYNKLLDEAQ 53
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 11-71 1.36e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 60.02  E-value: 1.36e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17506363    11 WKNTEDEILKAAIMKYGkNQWSRIASLLHRKSAKQCKARWFEWLDPGIKKTEWSREEDEKL 71
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
8-56 2.18e-10

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 56.46  E-value: 2.18e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 17506363      8 GGVWKNTEDEILKAAIMKYGKNQWSRIASLLHRKSAKQCKARWFEWLDP 56
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 6-95 3.62e-09

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 58.16  E-value: 3.62e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506363    6 IKGGVWKNTEDEILKAAIMKYGKNQWSRI---ASLLhrKSAKQCKARWFEWLDPGIKKTEWSREEDEKLLHLAKLMPTQW 82
Cdd:PLN03212  23 MKRGPWTVEEDEILVSFIKKEGEGRWRSLpkrAGLL--RCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLGNRW 100

                         90
                 ....*....|....
gi 17506363   83 RTIA-PIVGRTSAQ 95
Cdd:PLN03212 101 SLIAgRIPGRTDNE 114
 
Name Accession Description Interval E-value
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 2-197 2.85e-42

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 161.11  E-value: 2.85e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506363   2 VRVIIKGGVWKNTEDEILKAAIMKYGKNQWSRIASLLHRKSAKQCKARWFEWLDPGIKKTEWSREEDEKLLHLAKLMPTQ 81
Cdd:COG5147  14 MQTKRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQ 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506363  82 WRTIAPIV-GRTSAQCLERYEHLLDEAQrKAEGLDEEatetRKLKPGEIDPTPETKPARPDPIDMDDDELEMLSEARARL 160
Cdd:COG5147  94 WSTIADYKdRRTAQQCVERYVNTLEDLS-STHDSKLQ----RRNEFDKIDPFNENSARRPDIYEDELLEREVNREASYRL 168

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 17506363 161 ANTQGKKAKRKARERQLSDARRLASLQKRREMRAAGL 197
Cdd:COG5147 169 RVPRVSKADVKPREKGEENNPDIEDLQEMKELKSASI 205
Myb_Cef pfam11831
pre-mRNA splicing factor component; This family is a region of the Myb-Related Cdc5p/Cef1 ...
 397-590 3.99e-35

pre-mRNA splicing factor component; This family is a region of the Myb-Related Cdc5p/Cef1 proteins, in fungi, and is part of the pre-mRNA splicing factor complex.


Pssm-ID: 463366  Cd Length: 227  Bit Score: 133.16  E-value: 3.99e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506363   397 TPNTVlhaiaATPGTQSQ-FPGSTP--GGFATPAGsvaaTPFRDQMRINEEIAGSA-----------LEQKASLKRALAS 462
Cdd:pfam11831   1 TPNPL-----ATPFRTGNgGVGATPrrGFGATPLR----TPLRDKLNINPEDGMLVgetprdekqrqKEAKEQLRSGLAS 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506363   463 LPTPKNDFEVVGPDDDEVEGAVEDESNQdedgwIEDASER-AENKAKRNAEnRVRNMKMRSQVIQRSLPKPTKVNEQATR 541
Cdd:pfam11831  72 LPKPKNDFEIVLPEEEEEESETEAVEDS-----EEDAAERdAREQAEREAE-EEKELARRSQVVQRGLPRPSEVNLDVLR 145

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17506363   542 ATNSS--------ADDMVKAEMSKLLAWDVDNKPPSVI------------YSREELDAAADLIKQEAES 590
Cdd:pfam11831 146 PANDEppltdlqpAEELIKKEMATLLHHDALKYPLPGAaqpyleaspyedFSDEELAAAKELIAAEMAV 214
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 56-108 1.04e-29

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 111.63  E-value: 1.04e-29
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 17506363  56 PGIKKTEWSREEDEKLLHLAKLMPTQWRTIAPIVGRTSAQCLERYEHLLDEAQ 108
Cdd:cd11659   1 PSIKKTEWTREEDEKLLHLAKLLPTQWRTIAPIVGRTAQQCLERYNKLLDEAQ 53
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 11-71 1.36e-11

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 60.02  E-value: 1.36e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17506363    11 WKNTEDEILKAAIMKYGkNQWSRIASLLHRKSAKQCKARWFEWLDPGIKKTEWSREEDEKL 71
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 11-54 1.75e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 56.43  E-value: 1.75e-10
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 17506363  11 WKNTEDEILKAAIMKYGKNQWSRIASLLHRKSAKQCKARWFEWL 54
Cdd:cd00167   2 WTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
8-56 2.18e-10

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 56.46  E-value: 2.18e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 17506363      8 GGVWKNTEDEILKAAIMKYGKNQWSRIASLLHRKSAKQCKARWFEWLDP 56
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 9-54 5.07e-10

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 55.20  E-value: 5.07e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 17506363     9 GVWKNTEDEILKAAIMKYGkNQWSRIASLLHRKSAKQCKARWFEWL 54
Cdd:pfam00249   2 GPWTPEEDELLLEAVEKLG-NRWKKIAKLLPGRTDNQCKNRWQNYL 46
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 6-95 3.62e-09

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 58.16  E-value: 3.62e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506363    6 IKGGVWKNTEDEILKAAIMKYGKNQWSRI---ASLLhrKSAKQCKARWFEWLDPGIKKTEWSREEDEKLLHLAKLMPTQW 82
Cdd:PLN03212  23 MKRGPWTVEEDEILVSFIKKEGEGRWRSLpkrAGLL--RCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLGNRW 100

                         90
                 ....*....|....
gi 17506363   83 RTIA-PIVGRTSAQ 95
Cdd:PLN03212 101 SLIAgRIPGRTDNE 114
PLN03091 PLN03091
hypothetical protein; Provisional
 6-92 3.25e-08

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 56.52  E-value: 3.25e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17506363    6 IKGGVWKNTEDEILKAAIMKYGKNQWSRIASL--LHRkSAKQCKARWFEWLDPGIKKTEWSREEDEKLLHLAKLMPTQWR 83
Cdd:PLN03091  12 LRKGLWSPEEDEKLLRHITKYGHGCWSSVPKQagLQR-CGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRWS 90

                         90
                 ....*....|
gi 17506363   84 TIAP-IVGRT 92
Cdd:PLN03091  91 QIAAqLPGRT 100
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 60-100 2.50e-06

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 44.80  E-value: 2.50e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 17506363    60 KTEWSREEDEKLLHLAKLMPTQWRTIAPIV-GRTSAQCLERY 100
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLpGRTDNQCKNRW 42
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
60-104 1.33e-05

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 42.98  E-value: 1.33e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 17506363     60 KTEWSREEDEKLLHLAKLMPT-QWRTIAPIVG-RTSAQCLERYEHLL 104
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKnNWEKIAKELPgRTAEQCRERWRNLL 47
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 62-104 2.98e-05

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 41.79  E-value: 2.98e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 17506363  62 EWSREEDEKLLHL-AKLMPTQWRTIAPIVG-RTSAQCLERYEHLL 104
Cdd:cd00167   1 PWTEEEDELLLEAvKKYGKNNWEKIAKELPgRTPKQCRERWRNLL 45
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 63-117 3.56e-04

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 39.22  E-value: 3.56e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 17506363    63 WSREEDEKLLHLAKLMPTQWRTIAPIVG-RTSAQCLERYEHLLDEAQRKAEGLDEE 117
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGNDWKQIAKELGrRTPKQCFDRWRRKLNPKISRGPWSKEE 56
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 11-50 1.03e-03

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 37.55  E-value: 1.03e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 17506363  11 WKNTEDEILKAAIMKYGKNQWSRI---ASLLHRKSAKQCKARW 50
Cdd:cd11660   3 WTDEEDEALVEGVEKYGVGNWAKIlkdYFFVNNRTSVDLKDKW 45
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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