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Conserved domains on  [gi|71989928|ref|NP_492315|]
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Transient receptor potential channel [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LSDAT_euk pfam18139
SLOG in TRPM; Family in the SLOG superfamily, found in several eukaryotic channels including ...
392-656 9.28e-145

SLOG in TRPM; Family in the SLOG superfamily, found in several eukaryotic channels including diverse ciliate channels and the TRPM class of animal ion channels. Positioned near the N-terminus of all TRPM channels, it is predicted to play a regulatory role for the channel in potentially recognizing a universal nucleotide or nucleotide-derived ligand.


:

Pssm-ID: 465665  Cd Length: 266  Bit Score: 449.34  E-value: 9.28e-145
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989928    392 AQYVRVNFDTEPAYIMSLFEHVWQISPPRLIITVHGGTSNFDLQPKLARVFRKGLLKAASTTGAWIITSGCDTGVVKHVA 471
Cdd:pfam18139    1 AKYIRLSFDTDPEDLLHLMEKEWQLELPKLVISVHGGATNFELQPKLKRVFRKGLLKAAKTTGAWIITGGTNTGVMRHVG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989928    472 AALEGAQSAQRNKIVCIGIAPWGLLKKREDFIGQDKTVPYYPSSS-KGRFTGLNNRHSYFLLVDNGTVGRYGAEVILRKR 550
Cdd:pfam18139   81 DALKDLGSQSRRKIVTIGIAPWGIIKNREDLIGKDVVVPYQTLGNpKSKLAVLNNNHSHFLLVDDGTVGKYGAEIILRRR 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989928    551 LEMYISQKQKIFGGTRSVPVVCVVLEGGSCTIRSVLDYVTNVPRVPVVVCDGSGRAADLLAFAHQNVTEDGLLPDDIRRQ 630
Cdd:pfam18139  161 LEKYISQQKIHPRGGQGVPVVCVVVEGGPNTIKTVLEYVRDTPPVPVVVCDGSGRAADLLAFAHKYTHEDGQLPSSVKEQ 240
                          250       260
                   ....*....|....*....|....*.
gi 71989928    631 VLLLVETTFGCSEAAAHRLLHELTVC 656
Cdd:pfam18139  241 LLSLIQKTFGYSQKQAEKLLKQLMEC 266
TRPV super family cl40437
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
1295-1582 1.29e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


The actual alignment was detected with superfamily member TIGR00870:

Pssm-ID: 454755 [Multi-domain]  Cd Length: 743  Bit Score: 57.01  E-value: 1.29e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989928   1295 MRRRFYEfySAPISTF----WSWTISFILFITFFTYTLlvktpprptvieYILIAYVAAF--GLEQVRKIIMSDAKPFYE 1368
Cdd:TIGR00870  328 ELSDMYL--IAPLSRLgqfkWKPFIKFIFHSASYLYFL------------YLIIFTSVAYyrPTRTDLRVTGLQQTPLEM 393
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989928   1369 KIRTYVCSF-WNC--VTIL-AIIFYIVGF--FMRCFGSVAYGRVILA---------------CDSVL------------- 1414
Cdd:TIGR00870  394 LIVTWVDGLrLGEekLIWLgGIFEYIHQLwnILDFGMNSFYLATFLDrpfailfvtqaflvlREHWLrfdptlieealfa 473
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989928   1415 ------WTmKLLDYMSVHPKLGPYVTMAGKMIQN--MSYIIVMLVVtLLSFGLArqsitypdetwhwilvrniflkpYFM 1486
Cdd:TIGR00870  474 falvlsWL-NLLYIFRGNQHLGPLQIMIGRMILGdiLRFLFIYAVV-LFGFACG-----------------------LNQ 528
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989928   1487 LYGEVYADEIDTCgdeawdqhlenggpvilGNGTTGLSCVPGYWIPPLLMTFFLL------------------------- 1541
Cdd:TIGR00870  529 LYQYYDELKLNEC-----------------SNPHARSCEKQGNAYSTLFETSQELfwaiiglgdllanehkftefvglll 591
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*..
gi 71989928   1542 ------IANILLMSMLIAIFNHIFDATDEMSQQIWLFQRYKQVMEYE 1582
Cdd:TIGR00870  592 fgaynvIMYILLLNMLIAMMGNTYQLIADDADEEWKFQRAKLWMSYE 638
 
Name Accession Description Interval E-value
LSDAT_euk pfam18139
SLOG in TRPM; Family in the SLOG superfamily, found in several eukaryotic channels including ...
392-656 9.28e-145

SLOG in TRPM; Family in the SLOG superfamily, found in several eukaryotic channels including diverse ciliate channels and the TRPM class of animal ion channels. Positioned near the N-terminus of all TRPM channels, it is predicted to play a regulatory role for the channel in potentially recognizing a universal nucleotide or nucleotide-derived ligand.


Pssm-ID: 465665  Cd Length: 266  Bit Score: 449.34  E-value: 9.28e-145
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989928    392 AQYVRVNFDTEPAYIMSLFEHVWQISPPRLIITVHGGTSNFDLQPKLARVFRKGLLKAASTTGAWIITSGCDTGVVKHVA 471
Cdd:pfam18139    1 AKYIRLSFDTDPEDLLHLMEKEWQLELPKLVISVHGGATNFELQPKLKRVFRKGLLKAAKTTGAWIITGGTNTGVMRHVG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989928    472 AALEGAQSAQRNKIVCIGIAPWGLLKKREDFIGQDKTVPYYPSSS-KGRFTGLNNRHSYFLLVDNGTVGRYGAEVILRKR 550
Cdd:pfam18139   81 DALKDLGSQSRRKIVTIGIAPWGIIKNREDLIGKDVVVPYQTLGNpKSKLAVLNNNHSHFLLVDDGTVGKYGAEIILRRR 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989928    551 LEMYISQKQKIFGGTRSVPVVCVVLEGGSCTIRSVLDYVTNVPRVPVVVCDGSGRAADLLAFAHQNVTEDGLLPDDIRRQ 630
Cdd:pfam18139  161 LEKYISQQKIHPRGGQGVPVVCVVVEGGPNTIKTVLEYVRDTPPVPVVVCDGSGRAADLLAFAHKYTHEDGQLPSSVKEQ 240
                          250       260
                   ....*....|....*....|....*.
gi 71989928    631 VLLLVETTFGCSEAAAHRLLHELTVC 656
Cdd:pfam18139  241 LLSLIQKTFGYSQKQAEKLLKQLMEC 266
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
1295-1582 1.29e-07

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 57.01  E-value: 1.29e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989928   1295 MRRRFYEfySAPISTF----WSWTISFILFITFFTYTLlvktpprptvieYILIAYVAAF--GLEQVRKIIMSDAKPFYE 1368
Cdd:TIGR00870  328 ELSDMYL--IAPLSRLgqfkWKPFIKFIFHSASYLYFL------------YLIIFTSVAYyrPTRTDLRVTGLQQTPLEM 393
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989928   1369 KIRTYVCSF-WNC--VTIL-AIIFYIVGF--FMRCFGSVAYGRVILA---------------CDSVL------------- 1414
Cdd:TIGR00870  394 LIVTWVDGLrLGEekLIWLgGIFEYIHQLwnILDFGMNSFYLATFLDrpfailfvtqaflvlREHWLrfdptlieealfa 473
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989928   1415 ------WTmKLLDYMSVHPKLGPYVTMAGKMIQN--MSYIIVMLVVtLLSFGLArqsitypdetwhwilvrniflkpYFM 1486
Cdd:TIGR00870  474 falvlsWL-NLLYIFRGNQHLGPLQIMIGRMILGdiLRFLFIYAVV-LFGFACG-----------------------LNQ 528
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989928   1487 LYGEVYADEIDTCgdeawdqhlenggpvilGNGTTGLSCVPGYWIPPLLMTFFLL------------------------- 1541
Cdd:TIGR00870  529 LYQYYDELKLNEC-----------------SNPHARSCEKQGNAYSTLFETSQELfwaiiglgdllanehkftefvglll 591
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*..
gi 71989928   1542 ------IANILLMSMLIAIFNHIFDATDEMSQQIWLFQRYKQVMEYE 1582
Cdd:TIGR00870  592 fgaynvIMYILLLNMLIAMMGNTYQLIADDADEEWKFQRAKLWMSYE 638
 
Name Accession Description Interval E-value
LSDAT_euk pfam18139
SLOG in TRPM; Family in the SLOG superfamily, found in several eukaryotic channels including ...
392-656 9.28e-145

SLOG in TRPM; Family in the SLOG superfamily, found in several eukaryotic channels including diverse ciliate channels and the TRPM class of animal ion channels. Positioned near the N-terminus of all TRPM channels, it is predicted to play a regulatory role for the channel in potentially recognizing a universal nucleotide or nucleotide-derived ligand.


Pssm-ID: 465665  Cd Length: 266  Bit Score: 449.34  E-value: 9.28e-145
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989928    392 AQYVRVNFDTEPAYIMSLFEHVWQISPPRLIITVHGGTSNFDLQPKLARVFRKGLLKAASTTGAWIITSGCDTGVVKHVA 471
Cdd:pfam18139    1 AKYIRLSFDTDPEDLLHLMEKEWQLELPKLVISVHGGATNFELQPKLKRVFRKGLLKAAKTTGAWIITGGTNTGVMRHVG 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989928    472 AALEGAQSAQRNKIVCIGIAPWGLLKKREDFIGQDKTVPYYPSSS-KGRFTGLNNRHSYFLLVDNGTVGRYGAEVILRKR 550
Cdd:pfam18139   81 DALKDLGSQSRRKIVTIGIAPWGIIKNREDLIGKDVVVPYQTLGNpKSKLAVLNNNHSHFLLVDDGTVGKYGAEIILRRR 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989928    551 LEMYISQKQKIFGGTRSVPVVCVVLEGGSCTIRSVLDYVTNVPRVPVVVCDGSGRAADLLAFAHQNVTEDGLLPDDIRRQ 630
Cdd:pfam18139  161 LEKYISQQKIHPRGGQGVPVVCVVVEGGPNTIKTVLEYVRDTPPVPVVVCDGSGRAADLLAFAHKYTHEDGQLPSSVKEQ 240
                          250       260
                   ....*....|....*....|....*.
gi 71989928    631 VLLLVETTFGCSEAAAHRLLHELTVC 656
Cdd:pfam18139  241 LLSLIQKTFGYSQKQAEKLLKQLMEC 266
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
1295-1582 1.29e-07

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 57.01  E-value: 1.29e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989928   1295 MRRRFYEfySAPISTF----WSWTISFILFITFFTYTLlvktpprptvieYILIAYVAAF--GLEQVRKIIMSDAKPFYE 1368
Cdd:TIGR00870  328 ELSDMYL--IAPLSRLgqfkWKPFIKFIFHSASYLYFL------------YLIIFTSVAYyrPTRTDLRVTGLQQTPLEM 393
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989928   1369 KIRTYVCSF-WNC--VTIL-AIIFYIVGF--FMRCFGSVAYGRVILA---------------CDSVL------------- 1414
Cdd:TIGR00870  394 LIVTWVDGLrLGEekLIWLgGIFEYIHQLwnILDFGMNSFYLATFLDrpfailfvtqaflvlREHWLrfdptlieealfa 473
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989928   1415 ------WTmKLLDYMSVHPKLGPYVTMAGKMIQN--MSYIIVMLVVtLLSFGLArqsitypdetwhwilvrniflkpYFM 1486
Cdd:TIGR00870  474 falvlsWL-NLLYIFRGNQHLGPLQIMIGRMILGdiLRFLFIYAVV-LFGFACG-----------------------LNQ 528
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71989928   1487 LYGEVYADEIDTCgdeawdqhlenggpvilGNGTTGLSCVPGYWIPPLLMTFFLL------------------------- 1541
Cdd:TIGR00870  529 LYQYYDELKLNEC-----------------SNPHARSCEKQGNAYSTLFETSQELfwaiiglgdllanehkftefvglll 591
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*..
gi 71989928   1542 ------IANILLMSMLIAIFNHIFDATDEMSQQIWLFQRYKQVMEYE 1582
Cdd:TIGR00870  592 fgaynvIMYILLLNMLIAMMGNTYQLIADDADEEWKFQRAKLWMSYE 638
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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